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Recomendaciones de la Sociedad Española de Arteriosclerosis (SEA), 2019 Subject: Clínica e Investigación en Arteriosclerosis, 31 (2019) 128-139. doi:10.1016/j.arteri.2019.04.002 Keywords: Inhibidores de la proproteína convertasa subtilisina kexina 9; Colesterol; Lipoproteínas de baja densidad; Tratamiento; Indicaciones clínicas; Hipercolesterolemia familiar; Enfermedad cardiovascular; Documento de consenso; Número necesario a tratar; Proprotein convertase subtilisin kexin 9 inhibitors; Colesterol; Low density lipoprotein; Treatment; Clinical indications; Familial hypercholesterolemia; Cardiovascular disease; Consensus document; Number needed to treat Author: Juan Francisco Ascaso Creator: Elsevier Producer: Acrobat Distiller 9.0.0 (Windows) CreationDate: Sat Jun 1 17:17:11 2019 CEST ModDate: Fri Jun 7 13:16:47 2019 CEST Tagged: yes UserProperties: no Suspects: no Form: none JavaScript: no Pages: 12 Encrypted: no Page size: 595.28 x 793.7 pts Page rot: 0 File size: 924261 bytes Optimized: yes PDF version: 1.7 name type encoding emb sub uni object ID ------------------------------------ ----------------- ---------------- --- --- --- --------- HDEMJO+TrebuchetMS Type 1C Custom yes yes yes 3002 0 HDEMKP+Times-Roman Type 1C WinAnsi yes yes no 3004 0 HDEMLP+TrebuchetMS-Bold Type 1C Custom yes yes yes 3007 0 HDENEN+Univers Type 1C Custom yes yes yes 3010 0 HDEONE+NmtmibA Type 1C Custom yes yes yes 3013 0 HDEONF+MTSYB Type 1C Custom yes yes yes 3016 0 HDEOOF+TrebuchetMS-Italic Type 1C Custom yes yes yes 3019 0 HDEPCF+MTSY Type 1C Custom yes yes yes 3022 0 HDEPJD+TrebuchetSCR Type 1C Custom yes yes yes 2710 0 HDFCFC+Helvetica Type 1C WinAnsi yes yes no 2711 0 HDFEOC+Symbol Type 1C Custom yes yes yes 2713 0 Jhove (Rel. 1.22.1, 2019-04-17) Date: 2021-06-12 03:01:53 CEST RepresentationInformation: 222686.pdf ReportingModule: PDF-hul, Rel. 1.12.1 (2019-04-17) LastModified: 2021-06-11 13:13:23 CEST Size: 924261 Format: PDF Version: 1.7 Status: Well-Formed and valid SignatureMatches: PDF-hul MIMEtype: application/pdf Profile: Linearized PDF PDFMetadata: Objects: 0 FreeObjects: 1 IncrementalUpdates: 0 DocumentCatalog: PageLayout: SinglePage PageMode: UseOutlines Language: EN Outlines: Item: Title: Indicaciones de los inhibidores de PCSK9 en la práctica clínica. Recomendaciones de la Sociedad Española de Arterioscleros... Destination: 1 Children: Item: Title: Introducción Destination: 1 Item: Title: Estudios de prevención cardiovascular con IPCSK9 Destination: 1 Item: Title: Disminución del c-LDL y prevención cardiovascular Destination: 1 Item: Title: Hipercolesterolemia familiar Destination: 1 Children: Item: Title: Definición de hipercolesterolemia familiar heterocigota a efectos de la indicación de iPCSK9 Destination: 1 Item: Title: Estratificación del riesgo en los pacientes con hipercolesterolemia familiar Destination: 1 Item: Title: Hipercolesterolemia familiar homocigota Destination: 1 Item: Title: Prevención secundaria en los pacientes con enfermedad cardiovascular establecida. 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Recomendaciones de la Sociedad Española de Arteriosclerosis (SEA), 2019 Juan Francisco Ascaso Fernando Civeira Carlos Guijarro José López Miranda Luis Masana José María Mostaza Juan Pedro-Botet Xavier Pintó Pedro Valdivielso Clínica e Investigación en Arteriosclerosis, 31 (2019) 128-139. doi:10.1016/j.arteri.2019.04.002 The Authors Inhibidores de la proproteína convertasa subtilisina kexina 9 Colesterol Lipoproteínas de baja densidad Tratamiento Indicaciones clínicas Hipercolesterolemia familiar Enfermedad cardiovascular Documento de consenso Número necesario a tratar Proprotein convertase subtilisin kexin 9 inhibitors Colesterol Low density lipoprotein Treatment Clinical indications Familial hypercholesterolemia Cardiovascular disease Consensus document Number needed to treat journal Clínica e Investigación en Arteriosclerosis © 2019 The Authors S. Yamamoto. Publicado por Elsevier España, S.L.U. en nombre de Sociedad Española de Arteriosclerosis. Todos los derechos reservados. 0214-9168 31 3 May-June 2019 128-139 128 139 10.1016/j.arteri.2019.04.002 https://doi.org/10.1016/j.arteri.2019.04.002 2010-04-23 true 10.1016/j.arteri.2019.04.002 elsevier.com sciencedirect.com VoR 6.5 10.1016/j.arteri.2019.04.002 noindex 2010-04-23 true sciencedirect.com elsevier.com sciencedirect.com elsevier.com Elsevier 2019-06-01T15:17:11Z 2019-06-07T16:46:47+05:30 2019-06-07T16:46:47+05:30 True Unknown Acrobat Distiller 9.0.0 (Windows) Inhibidores de la proproteína convertasa subtilisina kexina 9; Colesterol; Lipoproteínas de baja densidad; Tratamiento; Indicaciones clínicas; Hipercolesterolemia familiar; Enfermedad cardiovascular; Documento de consenso; Número necesario a tratar; Proprotein convertase subtilisin kexin 9 inhibitors; Colesterol; Low density lipoprotein; Treatment; Clinical indications; Familial hypercholesterolemia; Cardiovascular disease; Consensus document; Number needed to treat uuid:f8ad9176-f910-4dd0-a6ff-9651578ef2aa 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Annotation: Subtype: Link Rect: 401, 530, 408, 534 Annotation: Subtype: Link Rect: 411, 530, 417, 535 Annotation: Subtype: Link Rect: 421, 530, 447, 536 Annotation: Subtype: Link Rect: 451, 528, 534, 536 Annotation: Subtype: Link Rect: 539, 530, 550, 535 Annotation: Subtype: Link Rect: 554, 530, 573, 535 Annotation: Subtype: Link Rect: 577, 530, 582, 535 Annotation: Subtype: Link Rect: 359, 518, 405, 526 Annotation: Subtype: Link Rect: 407, 522, 408, 522 Annotation: Subtype: Link Rect: 408, 522, 409, 522 Annotation: Subtype: Link Rect: 408, 522, 410, 522 Annotation: Subtype: Link Rect: 411, 520, 421, 526 Annotation: Subtype: Link Rect: 359, 510, 400, 516 Annotation: Subtype: Link Rect: 404, 508, 410, 515 Annotation: Subtype: Link Rect: 414, 510, 430, 516 Annotation: Subtype: Link Rect: 434, 508, 466, 516 Annotation: Subtype: Link Rect: 470, 508, 477, 515 Annotation: Subtype: Link Rect: 482, 510, 507, 516 Annotation: Subtype: Link Rect: 510, 508, 517, 515 Annotation: Subtype: Link Rect: 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Annotation: Subtype: Link Rect: 542, 430, 565, 436 Annotation: Subtype: Link Rect: 570, 430, 583, 436 Annotation: Subtype: Link Rect: 359, 418, 386, 426 Annotation: Subtype: Link Rect: 388, 420, 430, 426 Annotation: Subtype: Link Rect: 430, 420, 431, 421 Annotation: Subtype: Link Rect: 435, 419, 478, 426 Annotation: Subtype: Link Rect: 478, 422, 480, 423 Annotation: Subtype: Link Rect: 479, 422, 481, 423 Annotation: Subtype: Link Rect: 480, 422, 482, 423 Annotation: Subtype: Link Rect: 483, 420, 489, 426 Annotation: Subtype: Link Rect: 359, 410, 389, 416 Annotation: Subtype: Link Rect: 391, 409, 403, 416 Annotation: Subtype: Link Rect: 406, 408, 439, 416 Annotation: Subtype: Link Rect: 442, 410, 450, 416 Annotation: Subtype: Link Rect: 450, 409, 451, 411 Annotation: Subtype: Link Rect: 454, 410, 461, 416 Annotation: Subtype: Link Rect: 461, 410, 480, 416 Annotation: Subtype: Link Rect: 483, 409, 493, 416 Annotation: Subtype: Link Rect: 497, 410, 511, 416 Annotation: Subtype: Link Rect: 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Annotation: Subtype: Link Rect: 362, 339, 363, 341 Annotation: Subtype: Link Rect: 367, 340, 374, 346 Annotation: Subtype: Link Rect: 378, 340, 386, 346 Annotation: Subtype: Link Rect: 390, 340, 442, 346 Annotation: Subtype: Link Rect: 445, 339, 473, 346 Annotation: Subtype: Link Rect: 476, 340, 489, 346 Annotation: Subtype: Link Rect: 492, 339, 514, 346 Annotation: Subtype: Link Rect: 517, 340, 524, 346 Annotation: Subtype: Link Rect: 528, 340, 573, 346 Annotation: Subtype: Link Rect: 577, 340, 583, 346 Annotation: Subtype: Link Rect: 359, 329, 389, 336 Annotation: Subtype: Link Rect: 392, 329, 422, 336 Annotation: Subtype: Link Rect: 426, 330, 430, 336 Annotation: Subtype: Link Rect: 434, 329, 448, 336 Annotation: Subtype: Link Rect: 451, 330, 454, 336 Annotation: Subtype: Link Rect: 457, 330, 473, 336 Annotation: Subtype: Link Rect: 477, 329, 528, 336 Annotation: Subtype: Link Rect: 529, 332, 531, 333 Annotation: Subtype: Link Rect: 530, 332, 532, 333 Annotation: Subtype: Link Rect: 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404, 227 Annotation: Subtype: Link Rect: 403, 219, 405, 222 Annotation: Subtype: Link Rect: 410, 221, 413, 227 Annotation: Subtype: Link Rect: 413, 221, 441, 227 Annotation: Subtype: Link Rect: 445, 219, 456, 227 Annotation: Subtype: Link Rect: 461, 221, 464, 227 Annotation: Subtype: Link Rect: 465, 221, 476, 227 Annotation: Subtype: Link Rect: 479, 219, 493, 227 Annotation: Subtype: Link Rect: 498, 221, 506, 227 Annotation: Subtype: Link Rect: 510, 221, 533, 227 Annotation: Subtype: Link Rect: 538, 219, 550, 227 Annotation: Subtype: Link Rect: 555, 219, 583, 227 Annotation: Subtype: Link Rect: 359, 209, 369, 217 Annotation: Subtype: Link Rect: 373, 211, 393, 217 Annotation: Subtype: Link Rect: 396, 209, 402, 217 Annotation: Subtype: Link Rect: 405, 211, 412, 216 Annotation: Subtype: Link Rect: 414, 211, 423, 217 Annotation: Subtype: Link Rect: 426, 211, 452, 217 Annotation: Subtype: Link Rect: 454, 209, 482, 217 Annotation: Subtype: Link Rect: 484, 211, 497, 217 Annotation: Subtype: 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Annotation: Subtype: Link Rect: 465, 460, 499, 465 Annotation: Subtype: Link Rect: 503, 458, 535, 464 Annotation: Subtype: Link Rect: 535, 460, 536, 461 Annotation: Subtype: Link Rect: 542, 460, 566, 465 Annotation: Subtype: Link Rect: 571, 460, 574, 465 Annotation: Subtype: Link Rect: 575, 460, 591, 465 Annotation: Subtype: Link Rect: 367, 448, 410, 455 Annotation: Subtype: Link Rect: 411, 452, 413, 452 Annotation: Subtype: Link Rect: 412, 452, 413, 452 Annotation: Subtype: Link Rect: 413, 452, 414, 452 Annotation: Subtype: Link Rect: 415, 450, 425, 455 Annotation: Subtype: Link Rect: 367, 440, 398, 445 Annotation: Subtype: Link Rect: 402, 438, 408, 445 Annotation: Subtype: Link Rect: 412, 440, 435, 445 Annotation: Subtype: Link Rect: 438, 440, 446, 445 Annotation: Subtype: Link Rect: 445, 440, 447, 441 Annotation: Subtype: Link Rect: 451, 440, 455, 445 Annotation: Subtype: Link Rect: 455, 440, 494, 445 Annotation: Subtype: Link Rect: 497, 438, 524, 446 Annotation: Subtype: Link Rect: 528, 440, 536, 446 Annotation: Subtype: Link Rect: 540, 440, 545, 446 Annotation: Subtype: Link Rect: 549, 438, 591, 446 Annotation: Subtype: Link Rect: 367, 430, 402, 436 Annotation: Subtype: Link Rect: 407, 430, 442, 436 Annotation: Subtype: Link Rect: 445, 428, 449, 434 Annotation: Subtype: Link Rect: 453, 430, 477, 434 Annotation: Subtype: Link Rect: 481, 430, 523, 436 Annotation: Subtype: Link Rect: 526, 428, 573, 436 Annotation: Subtype: Link Rect: 577, 430, 591, 436 Annotation: Subtype: Link Rect: 367, 420, 380, 426 Annotation: Subtype: Link Rect: 384, 418, 406, 426 Annotation: Subtype: Link Rect: 410, 418, 457, 426 Annotation: Subtype: Link Rect: 458, 422, 460, 422 Annotation: Subtype: Link Rect: 459, 422, 461, 422 Annotation: Subtype: Link Rect: 460, 422, 462, 422 Annotation: Subtype: Link Rect: 463, 420, 473, 425 Annotation: Subtype: Link Rect: 367, 410, 399, 416 Annotation: Subtype: Link Rect: 399, 410, 420, 416 Annotation: Subtype: Link Rect: 425, 408, 432, 416 Annotation: Subtype: Link Rect: 437, 410, 458, 416 Annotation: Subtype: Link Rect: 463, 408, 473, 416 Annotation: Subtype: Link Rect: 479, 410, 501, 416 Annotation: Subtype: Link Rect: 506, 408, 512, 416 Annotation: Subtype: Link Rect: 518, 410, 546, 416 Annotation: Subtype: Link Rect: 551, 408, 558, 416 Annotation: Subtype: Link Rect: 563, 410, 591, 416 Annotation: Subtype: Link Rect: 367, 398, 380, 406 Annotation: Subtype: Link Rect: 385, 400, 396, 406 Annotation: Subtype: Link Rect: 401, 400, 405, 406 Annotation: Subtype: Link Rect: 405, 400, 419, 405 Annotation: Subtype: Link Rect: 424, 398, 430, 406 Annotation: Subtype: Link Rect: 435, 400, 442, 405 Annotation: Subtype: Link Rect: 447, 400, 455, 406 Annotation: Subtype: Link Rect: 461, 398, 483, 406 Annotation: Subtype: Link Rect: 488, 400, 501, 406 Annotation: Subtype: Link Rect: 506, 400, 537, 406 Annotation: Subtype: Link Rect: 542, 400, 549, 406 Annotation: Subtype: Link Rect: 554, 400, 565, 406 Annotation: Subtype: Link Rect: 570, 400, 591, 406 Annotation: Subtype: Link Rect: 367, 390, 379, 396 Annotation: Subtype: Link Rect: 383, 390, 444, 396 Annotation: Subtype: Link Rect: 447, 390, 464, 396 Annotation: Subtype: Link Rect: 469, 388, 519, 396 Annotation: Subtype: Link Rect: 523, 388, 550, 396 Annotation: Subtype: Link Rect: 554, 390, 566, 396 Annotation: Subtype: Link Rect: 570, 388, 591, 396 Annotation: Subtype: Link Rect: 367, 380, 374, 386 Annotation: Subtype: Link Rect: 378, 380, 417, 386 Annotation: Subtype: Link Rect: 422, 380, 428, 386 Annotation: Subtype: Link Rect: 432, 380, 470, 386 Annotation: Subtype: Link Rect: 474, 380, 489, 386 Annotation: Subtype: Link Rect: 494, 378, 509, 385 Annotation: Subtype: Link Rect: 511, 380, 514, 386 Annotation: Subtype: Link Rect: 519, 380, 549, 386 Annotation: Subtype: Link Rect: 553, 380, 565, 386 Annotation: Subtype: Link Rect: 570, 380, 591, 386 Annotation: Subtype: Link Rect: 367, 368, 415, 376 Annotation: Subtype: Link Rect: 419, 370, 426, 375 Annotation: Subtype: Link Rect: 429, 368, 443, 376 Annotation: Subtype: Link Rect: 446, 370, 497, 376 Annotation: Subtype: Link Rect: 500, 370, 514, 376 Annotation: Subtype: Link Rect: 518, 370, 556, 376 Annotation: Subtype: Link Rect: 559, 370, 591, 376 Annotation: Subtype: Link Rect: 367, 359, 408, 366 Annotation: Subtype: Link Rect: 367, 350, 397, 356 Annotation: Subtype: Link Rect: 401, 349, 413, 356 Annotation: Subtype: Link Rect: 418, 350, 438, 356 Annotation: Subtype: Link Rect: 442, 349, 453, 356 Annotation: Subtype: Link Rect: 457, 350, 464, 356 Annotation: Subtype: Link Rect: 464, 350, 483, 356 Annotation: Subtype: Link Rect: 487, 349, 497, 356 Annotation: Subtype: Link Rect: 502, 348, 535, 356 Annotation: Subtype: Link Rect: 539, 350, 547, 356 Annotation: Subtype: Link Rect: 547, 349, 548, 351 Annotation: Subtype: Link Rect: 553, 350, 591, 356 Annotation: Subtype: Link Rect: 367, 340, 371, 346 Annotation: Subtype: Link Rect: 370, 339, 372, 341 Annotation: Subtype: Link Rect: 376, 340, 384, 346 Annotation: Subtype: Link Rect: 389, 340, 412, 346 Annotation: Subtype: Link Rect: 416, 339, 429, 346 Annotation: Subtype: Link Rect: 433, 340, 440, 345 Annotation: Subtype: Link Rect: 444, 340, 452, 346 Annotation: Subtype: Link Rect: 457, 340, 509, 346 Annotation: Subtype: Link Rect: 512, 338, 534, 346 Annotation: Subtype: Link Rect: 537, 340, 549, 346 Annotation: Subtype: Link Rect: 553, 338, 581, 346 Annotation: Subtype: Link Rect: 585, 340, 592, 346 Annotation: Subtype: Link Rect: 367, 330, 378, 336 Annotation: Subtype: Link Rect: 382, 330, 403, 336 Annotation: Subtype: Link Rect: 407, 330, 437, 336 Annotation: Subtype: Link Rect: 441, 330, 483, 336 Annotation: Subtype: Link Rect: 487, 330, 493, 336 Annotation: Subtype: Link Rect: 497, 328, 525, 336 Annotation: Subtype: Link Rect: 529, 330, 544, 336 Annotation: Subtype: Link Rect: 548, 330, 560, 336 Annotation: Subtype: Link Rect: 564, 330, 591, 336 Annotation: Subtype: Link Rect: 367, 320, 397, 326 Annotation: Subtype: Link Rect: 401, 320, 413, 326 Annotation: Subtype: Link Rect: 417, 320, 428, 326 Annotation: Subtype: Link Rect: 432, 320, 453, 326 Annotation: Subtype: Link Rect: 456, 320, 463, 326 Annotation: Subtype: Link Rect: 467, 320, 509, 326 Annotation: Subtype: Link Rect: 512, 320, 520, 324 Annotation: Subtype: Link Rect: 524, 319, 559, 326 Annotation: Subtype: Link Rect: 563, 320, 575, 326 Annotation: Subtype: Link Rect: 579, 320, 592, 326 Annotation: Subtype: Link Rect: 367, 310, 374, 316 Annotation: Subtype: Link Rect: 379, 310, 415, 316 Annotation: Subtype: Link Rect: 420, 310, 452, 316 Annotation: Subtype: Link Rect: 457, 310, 462, 316 Annotation: Subtype: Link Rect: 467, 309, 509, 316 Annotation: Subtype: Link Rect: 514, 309, 542, 316 Annotation: Subtype: Link Rect: 546, 310, 553, 316 Annotation: Subtype: Link Rect: 558, 310, 569, 316 Annotation: Subtype: Link Rect: 574, 310, 591, 316 Annotation: Subtype: Link Rect: 367, 300, 383, 306 Annotation: Subtype: Link Rect: 386, 300, 426, 306 Annotation: Subtype: Link Rect: 430, 300, 466, 306 Annotation: Subtype: Link Rect: 470, 300, 486, 306 Annotation: Subtype: Link Rect: 491, 300, 514, 306 Annotation: Subtype: Link Rect: 518, 300, 548, 306 Annotation: Subtype: Link Rect: 552, 300, 591, 306 Annotation: Subtype: Link Rect: 367, 289, 405, 296 Annotation: Subtype: Link Rect: 407, 292, 408, 293 Annotation: Subtype: Link Rect: 408, 292, 409, 293 Annotation: Subtype: Link Rect: 409, 292, 410, 293 Annotation: Subtype: Link Rect: 411, 290, 421, 296 Annotation: Subtype: Link Rect: 376, 240, 511, 246 Flags: Print Annotation: Subtype: Link Rect: 367, 230, 390, 236 Annotation: Subtype: Link Rect: 394, 229, 400, 236 Annotation: Subtype: Link Rect: 405, 230, 429, 236 Annotation: Subtype: Link Rect: 434, 229, 439, 236 Annotation: Subtype: Link Rect: 444, 230, 461, 236 Annotation: Subtype: Link Rect: 465, 229, 472, 236 Annotation: Subtype: Link Rect: 477, 230, 537, 237 Annotation: Subtype: Link Rect: 541, 230, 545, 236 Annotation: Subtype: Link Rect: 544, 229, 545, 232 Annotation: Subtype: Link Rect: 551, 230, 580, 237 Annotation: Subtype: Link Rect: 585, 229, 591, 236 Annotation: Subtype: Link Rect: 367, 219, 418, 227 Annotation: Subtype: Link Rect: 422, 219, 427, 226 Annotation: Subtype: Link Rect: 431, 220, 438, 226 Annotation: Subtype: Link Rect: 441, 220, 449, 226 Annotation: Subtype: Link Rect: 453, 219, 503, 226 Annotation: Subtype: Link Rect: 507, 220, 527, 226 Annotation: Subtype: Link Rect: 530, 221, 536, 226 Annotation: Subtype: Link Rect: 539, 220, 566, 226 Annotation: Subtype: Link Rect: 569, 219, 591, 226 Annotation: Subtype: Link Rect: 367, 210, 426, 216 Annotation: Subtype: Link Rect: 429, 210, 432, 216 Annotation: Subtype: Link Rect: 436, 211, 446, 216 Annotation: Subtype: Link Rect: 449, 210, 463, 216 Annotation: Subtype: Link Rect: 466, 210, 493, 216 Annotation: Subtype: Link Rect: 496, 209, 543, 216 Annotation: Subtype: Link Rect: 544, 213, 546, 213 Annotation: Subtype: Link Rect: 545, 213, 547, 213 Annotation: Subtype: Link Rect: 546, 213, 548, 213 Annotation: Subtype: Link Rect: 549, 210, 555, 216 Annotation: Subtype: Link Rect: 367, 199, 410, 206 Annotation: Subtype: Link Rect: 414, 199, 425, 206 Annotation: Subtype: Link Rect: 430, 201, 448, 206 Annotation: Subtype: Link Rect: 452, 199, 458, 206 Annotation: Subtype: Link Rect: 463, 199, 496, 206 Annotation: Subtype: Link Rect: 500, 201, 508, 206 Annotation: Subtype: Link Rect: 508, 199, 509, 202 Annotation: Subtype: Link Rect: 514, 200, 535, 206 Annotation: Subtype: Link Rect: 540, 199, 554, 206 Annotation: Subtype: Link Rect: 560, 199, 591, 206 Annotation: Subtype: Link Rect: 367, 189, 373, 196 Annotation: Subtype: Link Rect: 377, 191, 430, 197 Annotation: Subtype: Link Rect: 433, 189, 437, 196 Annotation: Subtype: Link Rect: 440, 191, 448, 196 Annotation: Subtype: Link Rect: 450, 191, 459, 197 Annotation: Subtype: Link Rect: 462, 189, 515, 196 Annotation: Subtype: Link Rect: 519, 191, 540, 196 Annotation: Subtype: Link Rect: 543, 191, 576, 197 Annotation: Subtype: Link Rect: 579, 191, 591, 197 Annotation: Subtype: Link Rect: 367, 181, 418, 187 Annotation: Subtype: Link Rect: 421, 181, 435, 187 Annotation: Subtype: Link Rect: 438, 179, 464, 187 Annotation: Subtype: Link Rect: 466, 181, 482, 187 Annotation: Subtype: Link Rect: 485, 181, 496, 187 Annotation: Subtype: Link Rect: 498, 181, 528, 186 Annotation: Subtype: Link Rect: 530, 181, 547, 187 Annotation: Subtype: Link Rect: 550, 181, 591, 187 Annotation: Subtype: Link Rect: 367, 169, 418, 177 Annotation: Subtype: Link Rect: 419, 173, 421, 173 Annotation: Subtype: Link Rect: 420, 173, 422, 173 Annotation: Subtype: Link Rect: 421, 173, 423, 173 Annotation: Subtype: Link Rect: 424, 171, 434, 177 Annotation: Subtype: Link Rect: 367, 161, 371, 166 Annotation: Subtype: Link Rect: 371, 161, 396, 167 Annotation: Subtype: Link Rect: 399, 159, 404, 167 Annotation: Subtype: Link Rect: 408, 161, 426, 166 Annotation: Subtype: Link Rect: 429, 159, 434, 167 Annotation: Subtype: Link Rect: 438, 161, 473, 167 Annotation: Subtype: Link Rect: 476, 159, 487, 167 Annotation: Subtype: Link Rect: 490, 159, 521, 167 Annotation: Subtype: Link Rect: 524, 159, 536, 166 Annotation: Subtype: Link Rect: 539, 161, 543, 166 Annotation: Subtype: Link Rect: 543, 159, 577, 167 Annotation: Subtype: Link Rect: 579, 159, 591, 166 Annotation: Subtype: Link Rect: 367, 151, 402, 157 Annotation: Subtype: Link Rect: 405, 149, 416, 157 Annotation: Subtype: Link Rect: 419, 151, 426, 156 Annotation: Subtype: Link Rect: 429, 151, 437, 157 Annotation: Subtype: Link Rect: 441, 151, 461, 157 Annotation: Subtype: Link Rect: 463, 151, 470, 156 Annotation: Subtype: Link Rect: 470, 149, 491, 157 Annotation: Subtype: Link Rect: 494, 149, 515, 157 Annotation: Subtype: Link Rect: 518, 151, 522, 157 Annotation: Subtype: Link Rect: 522, 151, 582, 157 Annotation: Subtype: Link Rect: 584, 151, 591, 156 Annotation: Subtype: Link Rect: 367, 141, 371, 147 Annotation: Subtype: Link Rect: 371, 141, 392, 147 Annotation: Subtype: Link Rect: 396, 139, 481, 147 Annotation: Subtype: Link Rect: 485, 141, 498, 147 Annotation: Subtype: Link Rect: 501, 141, 508, 147 Annotation: Subtype: Link Rect: 511, 141, 563, 147 Annotation: Subtype: Link Rect: 566, 141, 591, 147 Annotation: Subtype: Link Rect: 367, 131, 379, 137 Annotation: Subtype: Link Rect: 382, 131, 403, 137 Annotation: Subtype: Link Rect: 406, 131, 437, 137 Annotation: Subtype: Link Rect: 440, 131, 443, 137 Annotation: Subtype: Link Rect: 446, 131, 457, 137 Annotation: Subtype: Link Rect: 460, 131, 473, 137 Annotation: Subtype: Link Rect: 476, 131, 503, 137 Annotation: Subtype: Link Rect: 507, 129, 550, 137 Annotation: Subtype: Link Rect: 551, 133, 553, 134 Annotation: Subtype: Link Rect: 552, 133, 553, 134 Annotation: Subtype: Link Rect: 553, 133, 554, 134 Annotation: Subtype: Link Rect: 555, 131, 565, 137 Annotation: Subtype: Link Rect: 367, 121, 382, 127 Annotation: Subtype: Link Rect: 386, 119, 395, 127 Annotation: Subtype: Link Rect: 399, 119, 432, 127 Annotation: Subtype: Link Rect: 436, 121, 444, 127 Annotation: Subtype: Link Rect: 444, 119, 445, 122 Annotation: Subtype: Link Rect: 449, 121, 479, 127 Annotation: Subtype: Link Rect: 483, 119, 494, 127 Annotation: Subtype: Link Rect: 498, 121, 502, 127 Annotation: Subtype: Link Rect: 503, 121, 518, 125 Annotation: Subtype: Link Rect: 521, 119, 533, 127 Annotation: Subtype: Link Rect: 537, 121, 554, 127 Annotation: Subtype: Link Rect: 558, 119, 564, 127 Annotation: Subtype: Link Rect: 568, 121, 591, 127 Annotation: Subtype: Link Rect: 367, 110, 379, 117 Annotation: Subtype: Link Rect: 384, 111, 391, 116 Annotation: Subtype: Link Rect: 395, 111, 403, 117 Annotation: Subtype: Link Rect: 408, 111, 429, 117 Annotation: Subtype: Link Rect: 433, 111, 503, 117 Annotation: Subtype: Link Rect: 507, 111, 540, 117 Annotation: Subtype: Link Rect: 544, 111, 550, 117 Annotation: Subtype: Link Rect: 555, 109, 572, 117 Annotation: Subtype: Link Rect: 576, 111, 591, 117 Page: Label: 12 Annotations: Annotation: Subtype: Link Rect: 102, 778, 146, 784 Annotation: Subtype: Link Rect: 149, 778, 158, 784 Annotation: Subtype: Link Rect: 161, 777, 188, 784 Annotation: Subtype: Link Rect: 191, 778, 198, 784 Annotation: Subtype: Link Rect: 201, 778, 208, 784 Annotation: Subtype: Link Rect: 211, 778, 236, 784 Annotation: Subtype: Link Rect: 238, 778, 256, 784 Annotation: Subtype: Link Rect: 259, 778, 271, 784 Annotation: Subtype: Link Rect: 274, 778, 285, 784 Annotation: Subtype: Link Rect: 288, 778, 301, 784 Annotation: Subtype: Link Rect: 304, 777, 325, 783 Annotation: Subtype: Link Rect: 102, 768, 112, 774 Annotation: Subtype: Link Rect: 113, 772, 114, 774 Annotation: Subtype: Link Rect: 114, 768, 117, 773 Annotation: Subtype: Link Rect: 120, 768, 136, 774 Annotation: Subtype: Link Rect: 139, 768, 142, 774 Annotation: Subtype: Link Rect: 146, 767, 162, 774 Annotation: Subtype: Link Rect: 166, 768, 170, 774 Annotation: Subtype: Link Rect: 170, 768, 179, 773 Annotation: Subtype: Link Rect: 183, 767, 230, 774 Annotation: Subtype: Link Rect: 231, 770, 232, 771 Annotation: Subtype: Link Rect: 232, 770, 233, 771 Annotation: Subtype: Link Rect: 233, 770, 234, 771 Annotation: Subtype: Link Rect: 235, 768, 245, 774 Annotation: Subtype: Link Rect: 102, 758, 127, 764 Annotation: Subtype: Link Rect: 131, 757, 137, 764 Annotation: Subtype: Link Rect: 142, 758, 148, 764 Annotation: Subtype: Link Rect: 148, 758, 161, 764 Annotation: Subtype: Link Rect: 165, 758, 175, 764 Annotation: Subtype: Link Rect: 174, 757, 175, 760 Annotation: Subtype: Link Rect: 180, 759, 184, 764 Annotation: Subtype: Link Rect: 184, 758, 210, 764 Annotation: Subtype: Link Rect: 214, 757, 225, 764 Annotation: Subtype: Link Rect: 230, 758, 250, 764 Annotation: Subtype: Link Rect: 255, 759, 258, 764 Annotation: Subtype: Link Rect: 258, 757, 259, 760 Annotation: Subtype: Link Rect: 264, 758, 287, 764 Annotation: Subtype: Link Rect: 291, 757, 304, 764 Annotation: Subtype: Link Rect: 308, 758, 325, 764 Annotation: Subtype: Link Rect: 102, 747, 117, 754 Annotation: Subtype: Link Rect: 122, 747, 128, 754 Annotation: Subtype: Link Rect: 134, 748, 141, 754 Annotation: Subtype: Link Rect: 146, 748, 154, 754 Annotation: Subtype: Link Rect: 161, 748, 181, 754 Annotation: Subtype: Link Rect: 187, 748, 194, 754 Annotation: Subtype: Link Rect: 199, 748, 238, 754 Annotation: Subtype: Link Rect: 243, 748, 251, 753 Annotation: Subtype: Link Rect: 257, 747, 305, 754 Annotation: Subtype: Link Rect: 311, 748, 326, 753 Annotation: Subtype: Link Rect: 102, 737, 107, 743 Annotation: Subtype: Link Rect: 109, 738, 120, 744 Annotation: Subtype: Link Rect: 121, 737, 140, 743 Annotation: Subtype: Link Rect: 143, 737, 162, 744 Annotation: Subtype: Link Rect: 165, 738, 176, 744 Annotation: Subtype: Link Rect: 179, 737, 199, 744 Annotation: Subtype: Link Rect: 201, 738, 205, 744 Annotation: Subtype: Link Rect: 208, 738, 238, 744 Annotation: Subtype: Link Rect: 241, 737, 275, 744 Annotation: Subtype: Link Rect: 278, 739, 289, 744 Annotation: Subtype: Link Rect: 292, 738, 295, 744 Annotation: Subtype: Link Rect: 298, 738, 325, 744 Annotation: Subtype: Link Rect: 102, 727, 145, 734 Annotation: Subtype: Link Rect: 145, 731, 147, 731 Annotation: Subtype: Link Rect: 146, 731, 148, 731 Annotation: Subtype: Link Rect: 147, 731, 149, 731 Annotation: Subtype: Link Rect: 150, 728, 156, 734 Annotation: Subtype: Link Rect: 102, 719, 126, 724 Annotation: Subtype: Link Rect: 129, 719, 133, 724 Annotation: Subtype: Link Rect: 133, 717, 134, 720 Annotation: Subtype: Link Rect: 137, 719, 160, 725 Annotation: Subtype: Link Rect: 163, 717, 170, 724 Annotation: Subtype: Link Rect: 173, 719, 178, 724 Annotation: Subtype: Link Rect: 178, 717, 201, 725 Annotation: Subtype: Link Rect: 204, 717, 215, 724 Annotation: Subtype: Link Rect: 218, 719, 237, 725 Annotation: Subtype: Link Rect: 240, 717, 250, 724 Annotation: Subtype: Link Rect: 254, 719, 268, 724 Annotation: Subtype: Link Rect: 271, 717, 277, 724 Annotation: Subtype: Link Rect: 281, 719, 295, 724 Annotation: Subtype: Link Rect: 298, 717, 304, 724 Annotation: Subtype: Link Rect: 307, 719, 314, 724 Annotation: Subtype: Link Rect: 317, 719, 325, 725 Annotation: Subtype: Link Rect: 102, 707, 119, 714 Annotation: Subtype: Link Rect: 122, 709, 134, 715 Annotation: Subtype: Link Rect: 137, 709, 189, 715 Annotation: Subtype: Link Rect: 191, 709, 227, 714 Annotation: Subtype: Link Rect: 230, 709, 239, 714 Annotation: Subtype: Link Rect: 242, 707, 269, 715 Annotation: Subtype: Link Rect: 272, 709, 288, 715 Annotation: Subtype: Link Rect: 291, 709, 302, 715 Annotation: Subtype: Link Rect: 305, 709, 325, 714 Annotation: Subtype: Link Rect: 102, 699, 114, 705 Annotation: Subtype: Link Rect: 117, 699, 155, 705 Annotation: Subtype: Link Rect: 158, 699, 175, 705 Annotation: Subtype: Link Rect: 178, 699, 219, 705 Annotation: Subtype: Link Rect: 222, 697, 243, 705 Annotation: Subtype: Link Rect: 246, 697, 285, 705 Annotation: Subtype: Link Rect: 286, 701, 288, 701 Annotation: Subtype: Link Rect: 287, 701, 289, 701 Annotation: Subtype: Link Rect: 288, 701, 290, 701 Annotation: Subtype: Link Rect: 291, 699, 296, 704 Annotation: Subtype: Link Rect: 102, 687, 135, 695 Annotation: Subtype: Link Rect: 137, 687, 148, 695 Annotation: Subtype: Link Rect: 152, 689, 179, 695 Annotation: Subtype: Link Rect: 182, 687, 186, 694 Annotation: Subtype: Link Rect: 189, 689, 197, 695 Annotation: Subtype: Link Rect: 201, 689, 224, 695 Annotation: Subtype: Link Rect: 227, 687, 234, 695 Annotation: Subtype: Link Rect: 237, 689, 244, 694 Annotation: Subtype: Link Rect: 244, 689, 265, 695 Annotation: Subtype: Link Rect: 268, 687, 275, 695 Annotation: Subtype: Link Rect: 279, 687, 311, 695 Annotation: Subtype: Link Rect: 314, 687, 325, 694 Annotation: Subtype: Link Rect: 102, 679, 124, 685 Annotation: Subtype: Link Rect: 128, 677, 134, 684 Annotation: Subtype: Link Rect: 139, 679, 146, 684 Annotation: Subtype: Link Rect: 149, 679, 157, 685 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Subtype: Link Rect: 469, 597, 498, 605 Annotation: Subtype: Link Rect: 502, 599, 517, 605 Annotation: Subtype: Link Rect: 521, 597, 557, 605 Annotation: Subtype: Link Rect: 562, 597, 583, 604 Annotation: Subtype: Link Rect: 359, 589, 386, 595 Annotation: Subtype: Link Rect: 390, 589, 431, 595 Annotation: Subtype: Link Rect: 434, 588, 481, 595 Annotation: Subtype: Link Rect: 482, 591, 484, 592 Annotation: Subtype: Link Rect: 483, 591, 485, 592 Annotation: Subtype: Link Rect: 484, 591, 486, 592 Annotation: Subtype: Link Rect: 487, 589, 497, 595 Annotation: Subtype: Link Rect: 358, 579, 384, 585 Annotation: Subtype: Link Rect: 391, 578, 397, 585 Annotation: Subtype: Link Rect: 405, 579, 408, 585 Annotation: Subtype: Link Rect: 408, 579, 447, 585 Annotation: Subtype: Link Rect: 453, 578, 459, 585 Annotation: Subtype: Link Rect: 467, 579, 491, 585 Annotation: Subtype: Link Rect: 498, 579, 502, 585 Annotation: Subtype: Link Rect: 501, 579, 502, 580 Annotation: Subtype: Link Rect: 511, 579, 551, 585 Annotation: Subtype: Link Rect: 558, 579, 583, 585 Annotation: Subtype: Link Rect: 359, 568, 404, 575 Annotation: Subtype: Link Rect: 409, 569, 431, 575 Annotation: Subtype: Link Rect: 436, 569, 447, 575 Annotation: Subtype: Link Rect: 452, 568, 506, 575 Annotation: Subtype: Link Rect: 510, 568, 583, 575 Annotation: Subtype: Link Rect: 359, 558, 391, 565 Annotation: Subtype: Link Rect: 394, 558, 423, 565 Annotation: Subtype: Link Rect: 426, 558, 451, 565 Annotation: Subtype: Link Rect: 454, 559, 465, 565 Annotation: Subtype: Link Rect: 468, 558, 522, 565 Annotation: Subtype: Link Rect: 525, 559, 544, 565 Annotation: Subtype: Link Rect: 547, 558, 583, 565 Annotation: Subtype: Link Rect: 358, 549, 414, 555 Annotation: Subtype: Link Rect: 418, 548, 464, 555 Annotation: Subtype: Link Rect: 466, 551, 468, 552 Annotation: Subtype: Link Rect: 467, 551, 468, 552 Annotation: Subtype: Link Rect: 468, 551, 469, 552 Annotation: Subtype: Link Rect: 470, 549, 476, 555 Annotation: Subtype: 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Annotation: Subtype: Link Rect: 567, 531, 568, 532 Annotation: Subtype: Link Rect: 569, 529, 575, 535 Annotation: Subtype: Link Rect: 359, 519, 385, 525 Annotation: Subtype: Link Rect: 388, 518, 394, 525 Annotation: Subtype: Link Rect: 398, 519, 423, 525 Annotation: Subtype: Link Rect: 427, 518, 432, 525 Annotation: Subtype: Link Rect: 436, 519, 475, 525 Annotation: Subtype: Link Rect: 478, 518, 485, 525 Annotation: Subtype: Link Rect: 489, 519, 508, 525 Annotation: Subtype: Link Rect: 511, 518, 518, 525 Annotation: Subtype: Link Rect: 521, 519, 526, 525 Annotation: Subtype: Link Rect: 526, 519, 534, 525 Annotation: Subtype: Link Rect: 537, 518, 544, 525 Annotation: Subtype: Link Rect: 547, 519, 583, 526 Annotation: Subtype: Link Rect: 358, 508, 366, 515 Annotation: Subtype: Link Rect: 369, 509, 376, 515 Annotation: Subtype: Link Rect: 379, 509, 387, 515 Annotation: Subtype: Link Rect: 391, 509, 418, 515 Annotation: Subtype: Link Rect: 421, 509, 428, 515 Annotation: Subtype: Link Rect: 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Subtype: Link Rect: 454, 491, 455, 492 Annotation: Subtype: Link Rect: 455, 491, 456, 492 Annotation: Subtype: Link Rect: 456, 491, 457, 492 Annotation: Subtype: Link Rect: 458, 489, 464, 495 Annotation: Subtype: Link Rect: 359, 478, 382, 485 Annotation: Subtype: Link Rect: 386, 478, 398, 485 Annotation: Subtype: Link Rect: 402, 479, 426, 485 Annotation: Subtype: Link Rect: 429, 478, 440, 485 Annotation: Subtype: Link Rect: 444, 479, 449, 485 Annotation: Subtype: Link Rect: 449, 479, 457, 485 Annotation: Subtype: Link Rect: 460, 478, 472, 485 Annotation: Subtype: Link Rect: 476, 480, 480, 485 Annotation: Subtype: Link Rect: 480, 479, 492, 484 Annotation: Subtype: Link Rect: 496, 478, 502, 485 Annotation: Subtype: Link Rect: 506, 479, 545, 485 Annotation: Subtype: Link Rect: 548, 480, 553, 485 Annotation: Subtype: Link Rect: 552, 478, 553, 481 Annotation: Subtype: Link Rect: 557, 479, 582, 485 Annotation: Subtype: Link Rect: 359, 469, 380, 475 Annotation: Subtype: Link Rect: 386, 470, 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Annotation: Subtype: Link Rect: 370, 430, 378, 435 Annotation: Subtype: Link Rect: 383, 430, 391, 436 Annotation: Subtype: Link Rect: 397, 428, 439, 436 Annotation: Subtype: Link Rect: 444, 428, 483, 436 Annotation: Subtype: Link Rect: 488, 430, 527, 436 Annotation: Subtype: Link Rect: 533, 428, 563, 436 Annotation: Subtype: Link Rect: 567, 430, 583, 436 Annotation: Subtype: Link Rect: 359, 420, 401, 426 Annotation: Subtype: Link Rect: 405, 420, 417, 426 Annotation: Subtype: Link Rect: 421, 420, 455, 425 Annotation: Subtype: Link Rect: 459, 420, 465, 426 Annotation: Subtype: Link Rect: 469, 418, 498, 426 Annotation: Subtype: Link Rect: 502, 420, 517, 426 Annotation: Subtype: Link Rect: 521, 418, 557, 426 Annotation: Subtype: Link Rect: 562, 418, 583, 425 Annotation: Subtype: Link Rect: 359, 410, 386, 416 Annotation: Subtype: Link Rect: 390, 410, 431, 416 Annotation: Subtype: Link Rect: 434, 408, 481, 416 Annotation: Subtype: Link Rect: 482, 412, 484, 412 Annotation: Subtype: Link Rect: 483, 412, 485, 412 Annotation: Subtype: Link Rect: 484, 412, 486, 412 Annotation: Subtype: Link Rect: 487, 410, 497, 416 Annotation: Subtype: Link Rect: 358, 350, 525, 356 Flags: Print Checksum: 0a4c8707 Type: CRC32 Checksum: 447b939eef7d7bb67da64ff848312ccc Type: MD5 Checksum: 8afb32e9090534be45d815cb754d52540c363c98 Type: SHA-1