8f8930375555d744b0a74ddd8d106190 222730.pdf f3a49826fb038d493d2931a60aa376f55af4a522 222730.pdf 1660bef6ea4d7cb2a655878227696f649a30e6fc2572e31fbae25b3fb202b5dd 222730.pdf Title: HDDMA_8480925 1..9 Creator: Aspose Ltd. Producer: Aspose.Pdf for .NET 10.1.0; modified using iTextSharp™ 5.4.0 ©2000-2012 1T3XT BVBA (AGPL-version) CreationDate: Mon Apr 15 10:00:38 2019 CEST ModDate: Thu May 16 13:22:30 2019 CEST Tagged: no UserProperties: no Suspects: no Form: none JavaScript: no Pages: 9 Encrypted: no Page size: 599.981 x 799.994 pts Page rot: 0 File size: 843745 bytes Optimized: no PDF version: 1.4 name type encoding emb sub uni object ID ------------------------------------ ----------------- ---------------- --- --- --- --------- MinionPro-Regular CID Type 0C Identity-H yes no yes 522 0 DNLPHO+MinionProIt Type 1C WinAnsi yes yes no 36 0 DNLPHP+Minion-Black Type 1C WinAnsi yes yes no 35 0 DNLPPN+MinionProBold Type 1C WinAnsi yes yes no 523 0 DNLPPO+MinionProIt2 Type 1C WinAnsi yes yes no 524 0 DNMAAP+MinionProRegular2 Type 1C WinAnsi yes yes no 32 0 DNMABA+MinionProRegular3 Type 1C Custom yes yes yes 34 0 DNMABB+MinionMath-Regular Type 1C WinAnsi yes yes no 37 0 DNMACC+MinionMath Italic2 Type 1C Custom yes yes yes 39 0 DNMACD+MinionMath Italic Type 1C WinAnsi yes yes no 38 0 DNMADE+MinionProRegular Type 1C WinAnsi yes yes no 33 0 LBFZFL+MinionPro-Regular CID TrueType Identity-H yes yes yes 1 0 MinionPro-Regular2 Type 1C Custom yes no yes 61 0 DNMANC+MinionMath-Regular-Graphic Type 1C Custom yes yes yes 62 0 DNMAOD+MinionScUnic Type 1C WinAnsi yes yes no 63 0 DNMBLP+MinionMath-Regular2 Type 1C Custom yes yes yes 78 0 MinionPro-Regular3 Type 1C Custom yes no no 116 0 DNMCLL+Minion-Black2 Type 1C WinAnsi yes yes no 206 0 DNMCPK+MinionProIt3 Type 1C Custom yes yes yes 214 0 Jhove (Rel. 1.22.1, 2019-04-17) Date: 2021-04-04 19:32:17 CEST RepresentationInformation: 222730.pdf ReportingModule: PDF-hul, Rel. 1.12.1 (2019-04-17) LastModified: 2020-11-11 15:48:22 CET Size: 843745 Format: PDF Version: 1.4 Status: Well-Formed, but not valid SignatureMatches: PDF-hul ID: PDF-HUL-122 ErrorMessage: edu.harvard.hul.ois.jhove.module.pdf.PdfInvalidException: Invalid indirect destination - referenced object 'link_B1' cannot be found Offset: 233500 ID: PDF-HUL-122 ErrorMessage: edu.harvard.hul.ois.jhove.module.pdf.PdfInvalidException: Invalid indirect destination - referenced object 'link_B2' cannot be found Offset: 233500 ID: PDF-HUL-122 ErrorMessage: edu.harvard.hul.ois.jhove.module.pdf.PdfInvalidException: Invalid indirect destination - referenced object 'link_B3' cannot be found Offset: 233500 ID: PDF-HUL-122 ErrorMessage: edu.harvard.hul.ois.jhove.module.pdf.PdfInvalidException: Invalid indirect destination - referenced object 'link_B4' cannot be found Offset: 233500 ID: PDF-HUL-122 ErrorMessage: edu.harvard.hul.ois.jhove.module.pdf.PdfInvalidException: Invalid indirect destination - referenced object 'link_B6' cannot be found Offset: 233500 ID: PDF-HUL-122 ErrorMessage: edu.harvard.hul.ois.jhove.module.pdf.PdfInvalidException: Invalid indirect destination - referenced object 'link_B7' cannot be found Offset: 233500 ID: PDF-HUL-122 ErrorMessage: edu.harvard.hul.ois.jhove.module.pdf.PdfInvalidException: Invalid indirect destination - referenced object 'link_B8' cannot be found Offset: 233500 ID: PDF-HUL-122 ErrorMessage: edu.harvard.hul.ois.jhove.module.pdf.PdfInvalidException: Invalid indirect destination - referenced object 'link_B9' cannot be found Offset: 233500 ID: PDF-HUL-122 ErrorMessage: edu.harvard.hul.ois.jhove.module.pdf.PdfInvalidException: Invalid indirect destination - referenced object 'link_B10' cannot be found Offset: 233500 ID: PDF-HUL-122 ErrorMessage: edu.harvard.hul.ois.jhove.module.pdf.PdfInvalidException: Invalid indirect destination - referenced object 'link_B11' cannot be found Offset: 233500 ID: PDF-HUL-122 ErrorMessage: edu.harvard.hul.ois.jhove.module.pdf.PdfInvalidException: Invalid indirect destination - referenced object 'link_B11' cannot be found Offset: 233500 ID: PDF-HUL-122 ErrorMessage: edu.harvard.hul.ois.jhove.module.pdf.PdfInvalidException: Invalid indirect destination - referenced object 'link_B13' cannot be found Offset: 233500 ID: PDF-HUL-122 ErrorMessage: edu.harvard.hul.ois.jhove.module.pdf.PdfInvalidException: Invalid indirect destination - referenced object 'link_B14' cannot be found Offset: 233500 ID: PDF-HUL-122 ErrorMessage: edu.harvard.hul.ois.jhove.module.pdf.PdfInvalidException: Invalid indirect destination - referenced object 'link_B15' cannot be found Offset: 233500 ID: PDF-HUL-122 ErrorMessage: edu.harvard.hul.ois.jhove.module.pdf.PdfInvalidException: Invalid indirect destination - referenced object 'link_B17' cannot be found Offset: 233500 ID: PDF-HUL-122 ErrorMessage: edu.harvard.hul.ois.jhove.module.pdf.PdfInvalidException: Invalid indirect destination - referenced object 'link_B18' cannot be found Offset: 233500 ID: PDF-HUL-122 ErrorMessage: edu.harvard.hul.ois.jhove.module.pdf.PdfInvalidException: Invalid indirect destination - referenced object 'link_B19' cannot be found Offset: 233500 ID: PDF-HUL-122 ErrorMessage: edu.harvard.hul.ois.jhove.module.pdf.PdfInvalidException: Invalid indirect destination - referenced object 'link_B20' cannot be found Offset: 233500 ID: PDF-HUL-122 ErrorMessage: edu.harvard.hul.ois.jhove.module.pdf.PdfInvalidException: Invalid indirect destination - referenced object 'link_B21' cannot be found Offset: 233500 ID: PDF-HUL-122 ErrorMessage: edu.harvard.hul.ois.jhove.module.pdf.PdfInvalidException: Invalid indirect destination - referenced object 'link_B22' cannot be found Offset: 233500 ID: PDF-HUL-122 ErrorMessage: edu.harvard.hul.ois.jhove.module.pdf.PdfInvalidException: Invalid indirect destination - referenced object 'link_B21' cannot be found Offset: 233500 ID: PDF-HUL-122 ErrorMessage: edu.harvard.hul.ois.jhove.module.pdf.PdfInvalidException: Invalid indirect destination - referenced object 'link_B24' cannot be found Offset: 233500 ID: PDF-HUL-122 ErrorMessage: edu.harvard.hul.ois.jhove.module.pdf.PdfInvalidException: Invalid indirect destination - referenced object 'link_B24' cannot be found Offset: 233500 ID: PDF-HUL-122 ErrorMessage: edu.harvard.hul.ois.jhove.module.pdf.PdfInvalidException: Invalid indirect destination - referenced object 'link_B5' cannot be found Offset: 233500 ID: PDF-HUL-122 ErrorMessage: edu.harvard.hul.ois.jhove.module.pdf.PdfInvalidException: Invalid indirect destination - referenced object 'link_B6' cannot be found Offset: 233500 ID: PDF-HUL-122 ErrorMessage: edu.harvard.hul.ois.jhove.module.pdf.PdfInvalidException: Invalid indirect destination - referenced object 'link_B25' cannot be found Offset: 233500 ID: PDF-HUL-122 ErrorMessage: edu.harvard.hul.ois.jhove.module.pdf.PdfInvalidException: Invalid indirect destination - referenced object 'link_fig1' cannot be found Offset: 233500 ID: PDF-HUL-122 ErrorMessage: edu.harvard.hul.ois.jhove.module.pdf.PdfInvalidException: Invalid indirect destination - referenced object 'link_fig2' cannot be found Offset: 233500 ID: PDF-HUL-122 ErrorMessage: edu.harvard.hul.ois.jhove.module.pdf.PdfInvalidException: Invalid indirect destination - referenced object 'link_fig3' cannot be found Offset: 233500 ID: PDF-HUL-122 ErrorMessage: edu.harvard.hul.ois.jhove.module.pdf.PdfInvalidException: Invalid indirect destination - referenced object 'link_fig4' cannot be found Offset: 233500 ID: PDF-HUL-122 ErrorMessage: edu.harvard.hul.ois.jhove.module.pdf.PdfInvalidException: Invalid indirect destination - referenced object 'link_fig5' cannot be found Offset: 233500 ID: PDF-HUL-122 ErrorMessage: edu.harvard.hul.ois.jhove.module.pdf.PdfInvalidException: Invalid indirect destination - referenced object 'link_B26' cannot be found Offset: 233500 ID: PDF-HUL-122 ErrorMessage: edu.harvard.hul.ois.jhove.module.pdf.PdfInvalidException: Invalid indirect destination - referenced object 'link_B7' cannot be found Offset: 233500 ID: PDF-HUL-122 ErrorMessage: edu.harvard.hul.ois.jhove.module.pdf.PdfInvalidException: Invalid indirect destination - referenced object 'link_B27' cannot be found Offset: 233500 ID: PDF-HUL-122 ErrorMessage: edu.harvard.hul.ois.jhove.module.pdf.PdfInvalidException: Invalid indirect destination - referenced object 'link_B28' cannot be found Offset: 233500 ID: PDF-HUL-122 ErrorMessage: edu.harvard.hul.ois.jhove.module.pdf.PdfInvalidException: Invalid indirect destination - referenced object 'link_B18' cannot be found Offset: 233500 ID: PDF-HUL-122 ErrorMessage: edu.harvard.hul.ois.jhove.module.pdf.PdfInvalidException: Invalid indirect destination - referenced object 'link_B29' cannot be found Offset: 233500 ID: PDF-HUL-122 ErrorMessage: edu.harvard.hul.ois.jhove.module.pdf.PdfInvalidException: Invalid indirect destination - referenced object 'link_B30' cannot be found Offset: 233500 ID: PDF-HUL-122 ErrorMessage: edu.harvard.hul.ois.jhove.module.pdf.PdfInvalidException: Invalid indirect destination - referenced object 'link_B31' cannot be found Offset: 233500 ID: PDF-HUL-122 ErrorMessage: edu.harvard.hul.ois.jhove.module.pdf.PdfInvalidException: Invalid indirect destination - referenced object 'link_B19' cannot be found Offset: 233500 ID: PDF-HUL-122 ErrorMessage: edu.harvard.hul.ois.jhove.module.pdf.PdfInvalidException: Invalid indirect destination - referenced object 'link_B21' cannot be found Offset: 233500 ID: PDF-HUL-122 ErrorMessage: edu.harvard.hul.ois.jhove.module.pdf.PdfInvalidException: Invalid indirect destination - referenced object 'link_B32' cannot be found Offset: 233500 ID: PDF-HUL-122 ErrorMessage: edu.harvard.hul.ois.jhove.module.pdf.PdfInvalidException: Invalid indirect destination - referenced object 'link_B33' cannot be found Offset: 233500 ID: PDF-HUL-122 ErrorMessage: edu.harvard.hul.ois.jhove.module.pdf.PdfInvalidException: Invalid indirect destination - referenced object 'link_B24' cannot be found Offset: 233500 ID: PDF-HUL-122 ErrorMessage: edu.harvard.hul.ois.jhove.module.pdf.PdfInvalidException: Invalid indirect destination - referenced object 'link_B18' cannot be found Offset: 233500 ID: PDF-HUL-122 ErrorMessage: edu.harvard.hul.ois.jhove.module.pdf.PdfInvalidException: Invalid indirect destination - referenced object 'link_B22' cannot be found Offset: 233500 ID: PDF-HUL-122 ErrorMessage: edu.harvard.hul.ois.jhove.module.pdf.PdfInvalidException: Invalid indirect destination - referenced object 'link_fig2' cannot be found Offset: 233500 ID: PDF-HUL-122 ErrorMessage: edu.harvard.hul.ois.jhove.module.pdf.PdfInvalidException: Invalid indirect destination - referenced object 'link_B24' cannot be found Offset: 233500 ID: PDF-HUL-122 ErrorMessage: edu.harvard.hul.ois.jhove.module.pdf.PdfInvalidException: Invalid indirect destination - referenced object 'link_B25' cannot be found Offset: 233500 ID: PDF-HUL-122 ErrorMessage: edu.harvard.hul.ois.jhove.module.pdf.PdfInvalidException: Invalid indirect destination - referenced object 'link_B25' cannot be found Offset: 233500 ID: PDF-HUL-122 ErrorMessage: edu.harvard.hul.ois.jhove.module.pdf.PdfInvalidException: Invalid indirect destination - referenced object 'link_B34' cannot be found Offset: 233500 ID: PDF-HUL-122 ErrorMessage: edu.harvard.hul.ois.jhove.module.pdf.PdfInvalidException: Invalid indirect destination - referenced object 'link_B35' cannot be found Offset: 233500 ID: PDF-HUL-122 ErrorMessage: edu.harvard.hul.ois.jhove.module.pdf.PdfInvalidException: Invalid indirect destination - referenced object 'link_B36' cannot be found Offset: 233500 ID: PDF-HUL-122 ErrorMessage: edu.harvard.hul.ois.jhove.module.pdf.PdfInvalidException: Invalid indirect destination - referenced object 'link_B22' cannot be found Offset: 233500 ID: PDF-HUL-122 ErrorMessage: edu.harvard.hul.ois.jhove.module.pdf.PdfInvalidException: Invalid indirect destination - referenced object 'link_B27' cannot be found Offset: 233500 ID: PDF-HUL-122 ErrorMessage: edu.harvard.hul.ois.jhove.module.pdf.PdfInvalidException: Invalid indirect destination - referenced object 'link_B37' cannot be found Offset: 233500 ID: PDF-HUL-122 ErrorMessage: edu.harvard.hul.ois.jhove.module.pdf.PdfInvalidException: Invalid indirect destination - referenced object 'link_B22' cannot be found Offset: 233500 ID: PDF-HUL-122 ErrorMessage: edu.harvard.hul.ois.jhove.module.pdf.PdfInvalidException: Invalid indirect destination - referenced object 'link_B38' cannot be found Offset: 233500 ID: PDF-HUL-122 ErrorMessage: edu.harvard.hul.ois.jhove.module.pdf.PdfInvalidException: Invalid indirect destination - referenced object 'link_B39' cannot be found Offset: 233500 ID: PDF-HUL-122 ErrorMessage: edu.harvard.hul.ois.jhove.module.pdf.PdfInvalidException: Invalid indirect destination - referenced object 'link_B7' cannot be found Offset: 233500 ID: PDF-HUL-122 ErrorMessage: edu.harvard.hul.ois.jhove.module.pdf.PdfInvalidException: Invalid indirect destination - referenced object 'link_B40' cannot be found Offset: 233500 ID: PDF-HUL-122 ErrorMessage: edu.harvard.hul.ois.jhove.module.pdf.PdfInvalidException: Invalid indirect destination - referenced object 'link_B41' cannot be found Offset: 233500 ID: PDF-HUL-122 ErrorMessage: edu.harvard.hul.ois.jhove.module.pdf.PdfInvalidException: Invalid indirect destination - referenced object 'link_B27' cannot be found Offset: 233500 ID: PDF-HUL-122 ErrorMessage: edu.harvard.hul.ois.jhove.module.pdf.PdfInvalidException: Invalid indirect destination - referenced object 'link_B31' cannot be found Offset: 233500 ID: PDF-HUL-122 ErrorMessage: edu.harvard.hul.ois.jhove.module.pdf.PdfInvalidException: Invalid indirect destination - referenced object 'link_B24' cannot be found Offset: 233500 ID: PDF-HUL-122 ErrorMessage: edu.harvard.hul.ois.jhove.module.pdf.PdfInvalidException: Invalid indirect destination - referenced object 'link_B22' cannot be found Offset: 233500 ID: PDF-HUL-122 ErrorMessage: edu.harvard.hul.ois.jhove.module.pdf.PdfInvalidException: Invalid indirect destination - referenced object 'link_B42' cannot be found Offset: 233500 ID: PDF-HUL-122 ErrorMessage: edu.harvard.hul.ois.jhove.module.pdf.PdfInvalidException: Invalid indirect destination - referenced object 'link_B43' cannot be found Offset: 233500 ID: PDF-HUL-122 ErrorMessage: edu.harvard.hul.ois.jhove.module.pdf.PdfInvalidException: Invalid indirect destination - referenced object 'link_B44' cannot be found Offset: 233500 ID: PDF-HUL-122 ErrorMessage: edu.harvard.hul.ois.jhove.module.pdf.PdfInvalidException: Invalid indirect destination - referenced object 'link_B8' cannot be found Offset: 233500 ID: PDF-HUL-122 ErrorMessage: edu.harvard.hul.ois.jhove.module.pdf.PdfInvalidException: Invalid indirect destination - referenced object 'link_B45' cannot be found Offset: 233500 ID: PDF-HUL-122 ErrorMessage: edu.harvard.hul.ois.jhove.module.pdf.PdfInvalidException: Invalid indirect destination - referenced object 'link_B46' cannot be found Offset: 233500 ID: PDF-HUL-122 ErrorMessage: edu.harvard.hul.ois.jhove.module.pdf.PdfInvalidException: Invalid indirect destination - referenced object 'link_B47' cannot be found Offset: 233500 ID: PDF-HUL-122 ErrorMessage: edu.harvard.hul.ois.jhove.module.pdf.PdfInvalidException: Invalid indirect destination - referenced object 'link_B48' cannot be found Offset: 233500 ID: PDF-HUL-122 ErrorMessage: edu.harvard.hul.ois.jhove.module.pdf.PdfInvalidException: Invalid indirect destination - referenced object 'link_B49' cannot be found Offset: 233500 ID: PDF-HUL-122 ErrorMessage: edu.harvard.hul.ois.jhove.module.pdf.PdfInvalidException: Invalid indirect destination - referenced object 'link_B50' cannot be found Offset: 233500 ID: PDF-HUL-122 ErrorMessage: edu.harvard.hul.ois.jhove.module.pdf.PdfInvalidException: Invalid indirect destination - referenced object 'link_B51' cannot be found Offset: 233500 ID: PDF-HUL-122 ErrorMessage: edu.harvard.hul.ois.jhove.module.pdf.PdfInvalidException: Invalid indirect destination - referenced object 'link_B52' cannot be found Offset: 233500 ID: PDF-HUL-122 ErrorMessage: edu.harvard.hul.ois.jhove.module.pdf.PdfInvalidException: Invalid indirect destination - referenced object 'link_B53' cannot be found Offset: 233500 ID: PDF-HUL-122 ErrorMessage: edu.harvard.hul.ois.jhove.module.pdf.PdfInvalidException: Invalid indirect destination - referenced object 'link_B54' cannot be found Offset: 233500 ID: PDF-HUL-122 ErrorMessage: edu.harvard.hul.ois.jhove.module.pdf.PdfInvalidException: Invalid indirect destination - referenced object 'link_B56' cannot be found Offset: 233500 MIMEtype: application/pdf PDFMetadata: Objects: 615 FreeObjects: 1 IncrementalUpdates: 0 DocumentCatalog: PageLayout: SinglePage PageMode: UseNone Outlines: Item: Title: Does Whole-Blood Neutrophil Gelatinase-Associated Lipocalin Stratify Acute Kidney Injury in Critically Ill Patients? Destination: edu.harvard.hul.ois.jhove.module.pdf.PdfSimpleObject@4eb7f003 Item: Title: 1. Introduction Destination: edu.harvard.hul.ois.jhove.module.pdf.PdfSimpleObject@eafc191 Item: Title: 2. Methods Destination: edu.harvard.hul.ois.jhove.module.pdf.PdfSimpleObject@612fc6eb Children: Item: Title: 2.1. Patients Destination: edu.harvard.hul.ois.jhove.module.pdf.PdfSimpleObject@1060b431 Item: Title: 2.2. Clinical and Laboratory Data Collection Destination: edu.harvard.hul.ois.jhove.module.pdf.PdfSimpleObject@612679d6 Item: Title: 2.3. Statistical Analysis Destination: edu.harvard.hul.ois.jhove.module.pdf.PdfSimpleObject@11758f2a Item: Title: 3. Results Destination: edu.harvard.hul.ois.jhove.module.pdf.PdfSimpleObject@e720b71 Children: Item: Title: 3.1. Clinical Characteristics Destination: edu.harvard.hul.ois.jhove.module.pdf.PdfSimpleObject@1b26f7b2 Item: Title: 3.2. Whole-Blood NGAL and AKI Destination: edu.harvard.hul.ois.jhove.module.pdf.PdfSimpleObject@491cc5c9 Item: Title: 3.3. Whole-Blood NGAL and Sepsis Destination: edu.harvard.hul.ois.jhove.module.pdf.PdfSimpleObject@74ad1f1f Item: Title: 4. Discussion Destination: edu.harvard.hul.ois.jhove.module.pdf.PdfSimpleObject@6a1aab78 Item: Title: 5. Conclusions Destination: edu.harvard.hul.ois.jhove.module.pdf.PdfSimpleObject@462d5aee Item: Title: Data Availability Destination: edu.harvard.hul.ois.jhove.module.pdf.PdfSimpleObject@69b0fd6f Item: Title: Conflicts of Interest Destination: edu.harvard.hul.ois.jhove.module.pdf.PdfSimpleObject@757942a1 Item: Title: Authors’ Contributions Destination: edu.harvard.hul.ois.jhove.module.pdf.PdfSimpleObject@4a87761d Item: Title: Acknowledgments Destination: edu.harvard.hul.ois.jhove.module.pdf.PdfSimpleObject@66d1af89 Item: Title: Supplementary Materials Destination: edu.harvard.hul.ois.jhove.module.pdf.PdfSimpleObject@8646db9 Info: Title: HDDMA_8480925 1..9 Creator: Aspose Ltd. Producer: Aspose.Pdf for .NET 10.1.0; modified using iTextSharp™ 5.4.0 ©2000-2012 1T3XT BVBA (AGPL-version) CreationDate: Mon Apr 15 10:00:38 CEST 2019 ModDate: Thu May 16 13:22:30 CEST 2019 ID: 0x4e958f229409a7d2ebb5e6704efa712b, 0x1d8006d2473169b71019795ba126836f Filters: FilterPipeline: FlateDecode Fonts: Type0: Font: BaseFont: LBFZFL+MinionPro-Regular Encoding: Identity-H ToUnicode: true Font: BaseFont: MinionPro-Regular Encoding: Identity-H ToUnicode: true Type1: Font: BaseFont: DNMAAP+MinionProRegular2 FontSubset: true FirstChar: 32 LastChar: 252 FontDescriptor: FontName: DNMAAP+MinionProRegular2 Flags: Serif, Nonsymbolic FontBBox: -20, -250, 947, 854 FontFile3: true Encoding: WinAnsiEncoding Font: BaseFont: DNMADE+MinionProRegular FontSubset: true FirstChar: 32 LastChar: 151 FontDescriptor: FontName: DNMADE+MinionProRegular Flags: Nonsymbolic FontBBox: -1187, -260, 1333, 833 FontFile3: true Encoding: WinAnsiEncoding Font: BaseFont: DNMABA+MinionProRegular3 FontSubset: true FirstChar: 1 LastChar: 17 FontDescriptor: FontName: DNMABA+MinionProRegular3 Flags: Symbolic FontBBox: 0, -10, 781, 708 FontFile3: true EncodingDictionary: Differences: true ToUnicode: true Font: BaseFont: DNLPHP+Minion-Black FontSubset: true FirstChar: 32 LastChar: 250 FontDescriptor: FontName: DNLPHP+Minion-Black Flags: Serif, Nonsymbolic FontBBox: -20, -250, 947, 822 FontFile3: true Encoding: WinAnsiEncoding Font: BaseFont: DNLPHO+MinionProIt FontSubset: true FirstChar: 32 LastChar: 242 FontDescriptor: FontName: DNLPHO+MinionProIt Flags: Serif, Nonsymbolic FontBBox: -135, -250, 1000, 854 FontFile3: true Encoding: WinAnsiEncoding Font: BaseFont: DNMABB+MinionMath-Regular FontSubset: true FirstChar: 32 LastChar: 177 FontDescriptor: FontName: DNMABB+MinionMath-Regular Flags: Nonsymbolic FontBBox: -20, -427, 1541, 1072 FontFile3: true Encoding: WinAnsiEncoding Font: BaseFont: DNMACD+MinionMath Italic FontSubset: true FirstChar: 32 LastChar: 116 FontDescriptor: FontName: DNMACD+MinionMath Italic Flags: Nonsymbolic FontBBox: -333, -260, 1000, 864 FontFile3: true Encoding: WinAnsiEncoding Font: BaseFont: DNMACC+MinionMath Italic2 FontSubset: true FirstChar: 1 LastChar: 16 FontDescriptor: FontName: DNMACC+MinionMath Italic2 Flags: Symbolic FontBBox: -333, -270, 989, 781 FontFile3: true EncodingDictionary: Differences: true ToUnicode: true Font: BaseFont: DNLPPN+MinionProBold FontSubset: true FirstChar: 32 LastChar: 50 FontDescriptor: FontName: DNLPPN+MinionProBold Flags: Nonsymbolic FontBBox: -20, -239, 968, 854 FontFile3: true Encoding: WinAnsiEncoding Font: BaseFont: DNLPPO+MinionProIt2 FontSubset: true FirstChar: 32 LastChar: 146 FontDescriptor: FontName: DNLPPO+MinionProIt2 Flags: Nonsymbolic FontBBox: -1187, -260, 1312, 822 FontFile3: true Encoding: WinAnsiEncoding Font: BaseFont: DNMBLP+MinionMath-Regular2 FontSubset: true FirstChar: 1 LastChar: 13 FontDescriptor: FontName: DNMBLP+MinionMath-Regular2 Flags: Symbolic FontBBox: -135, -385, 1333, 895 FontFile3: true EncodingDictionary: Differences: true ToUnicode: true Font: BaseFont: DNMCLL+Minion-Black2 FontSubset: true FirstChar: 32 LastChar: 146 FontDescriptor: FontName: DNMCLL+Minion-Black2 Flags: Nonsymbolic FontBBox: -166, -135, 1114, 770 FontFile3: true Encoding: WinAnsiEncoding Font: BaseFont: MinionPro-Regular3 FirstChar: 21 LastChar: 150 FontDescriptor: FontName: MinionPro-Regular3 Flags: Nonsymbolic FontBBox: -290, -360, 1684, 989 FontFile3: true EncodingDictionary: BaseEncoding: WinAnsiEncoding Differences: true Font: BaseFont: DNMCPK+MinionProIt3 FontSubset: true FirstChar: 1 LastChar: 13 FontDescriptor: FontName: DNMCPK+MinionProIt3 Flags: Symbolic FontBBox: -156, -250, 802, 708 FontFile3: true EncodingDictionary: Differences: true ToUnicode: true Font: BaseFont: MinionPro-Regular2 FirstChar: 2 LastChar: 138 FontDescriptor: FontName: MinionPro-Regular2 Flags: Symbolic FontBBox: -290, -360, 1684, 989 FontFile3: true EncodingDictionary: Differences: true ToUnicode: true Font: BaseFont: DNMANC+MinionMath-Regular-Graphic FontSubset: true FirstChar: 2 LastChar: 124 FontDescriptor: FontName: DNMANC+MinionMath-Regular-Graphic Flags: Symbolic FontBBox: 12, -261, 570, 518 FontFile3: true EncodingDictionary: Differences: true ToUnicode: true Font: BaseFont: DNMAOD+MinionScUnic FontSubset: true FirstChar: 32 LastChar: 117 FontDescriptor: FontName: DNMAOD+MinionScUnic Flags: Nonsymbolic FontBBox: -218, -250, 937, 802 FontFile3: true Encoding: WinAnsiEncoding CIDFontType0: Font: BaseFont: MinionPro-Regular CIDSystemInfo: Registry: Adobe Registry: Identity Supplement: 0 FontDescriptor: FontName: MinionPro-Regular Flags: Nonsymbolic FontBBox: -290, -360, 1684, 989 FontFile3: true CIDFontType2: Font: BaseFont: LBFZFL+MinionPro-Regular CIDSystemInfo: Registry: Adobe Registry: Identity Supplement: 0 FontDescriptor: FontName: LBFZFL+MinionPro-Regular Flags: Nonsymbolic FontBBox: -289, -360, 1684, 917 FontFile2: true XMP: application/pdfDoes Whole-Blood Neutrophil Gelatinase-Associated Lipocalin Stratify Acute Kidney Injury in Critically Ill Patients?Cuartero, M.Betbesé, A. J.Núñez, K.Baldirà, J.Ordonez-Llanos, J.Purpose. To analyse the capacity of whole-blood NGAL (wbNGAL) to stratify AKI in critically ill patients with and without sepsis. Methods. Whole-blood NGAL was measured with a point-of-care device at admission and 48 hours later in patients admitted to a general ICU. Patients were classified by the AKIN and KDIGO classifications at admission and 24 and 48 hours. We performed an ROC curve analysis. wbNGAL values at admission were compared in patients with sepsis and septic shock. Results. The study included 100 consecutively admitted patients (40 female) with mean age 59.1±17.8 years. Thirty-three patients presented AKI at admission, and 10 more developed it in the next 48 h. Eighteen patients had AKI stage 3, 14 of them at admission. Nine patients required renal replacement therapy. According to KDIGO at admission, wbNGAL values were 78 μg/L (60-187) in stage 0 (n=67), 263 μg/L (89-314) in stage 1 (n=8), 484 μg/L (333-708) in stage 2 (n=11), and 623 μg/L (231-911) in stage 3 (n=14), p=0.0001 for trend. Ten patients did not complete 48 hours of study: 6 of 10 were discharged (initial wbNGAL 130 μg/L (60-514)) and 4 died (773 μg/L (311-1010)). The AUROC curve of wbNGAL to predict AKI was 0.838 (95% confidence interval 0.76-0.92, p=0.0001), with optimal cut-off value of 178 μg/L (sensitivity 76.7%, specificity 78.9%, p<0.0001). At admission, twenty-nine patients had sepsis, of whom 20 were in septic shock. wbNGAL concentrations were 81 μg/L (60-187) in patients without sepsis, 481 (247-687) in those with sepsis, and 623.5 μg/L (361-798) in the subgroup of septic shock (p<0.0001). Conclusions. Whole-blood NGAL concentration at ICU admission was a good stratifier of AKI in critically ill patients. However, wbNGAL concentrations were higher in septic patients irrespective of AKI occurrence.Disease MarkersHindawi2019/05/02Research articledoi:10.1155/2019/8480925en Pages: Page: Label: 1 Annotations: Annotation: Subtype: Link Rect: 149, 557, 159, 567 Flags: Print AppearanceDictionary: true Annotation: Subtype: Link Rect: 228, 157, 233, 167 Flags: Print AppearanceDictionary: true Destination: null Annotation: Subtype: Link Rect: 73, 135, 78, 145 Flags: Print AppearanceDictionary: true Destination: null Annotation: Subtype: Link Rect: 83, 135, 88, 145 Flags: Print AppearanceDictionary: true Destination: null Annotation: Subtype: Link Rect: 228, 100, 233, 110 Flags: Print AppearanceDictionary: true Destination: null Annotation: Subtype: Link Rect: 238, 100, 243, 110 Flags: Print AppearanceDictionary: true Destination: null Annotation: Subtype: Link Rect: 210, 66, 214, 76 Flags: Print AppearanceDictionary: true Destination: null Annotation: Subtype: Link Rect: 219, 66, 224, 76 Flags: Print AppearanceDictionary: true Destination: null Annotation: Subtype: Link Rect: 356, 180, 361, 190 Flags: Print AppearanceDictionary: true Destination: null Annotation: Subtype: Link Rect: 479, 169, 488, 179 Flags: Print AppearanceDictionary: true Destination: null Annotation: Subtype: Link Rect: 471, 123, 480, 133 Flags: Print AppearanceDictionary: true Destination: null Annotation: Subtype: Link Rect: 357, 89, 367, 99 Flags: Print AppearanceDictionary: true Destination: null Annotation: Subtype: Link Rect: 372, 89, 382, 99 Flags: Print AppearanceDictionary: true Destination: null Annotation: Subtype: Link Rect: 534, 78, 544, 88 Flags: Print AppearanceDictionary: true Destination: null Annotation: Subtype: Link Rect: 405, 425, 548, 435 Flags: Print AppearanceDictionary: true Annotation: Subtype: Link Rect: 405, 425, 548, 435 Flags: Print AppearanceDictionary: true Annotation: Subtype: Link Rect: 405, 425, 548, 435 Flags: Print AppearanceDictionary: true Annotation: Subtype: Link Rect: 405, 425, 548, 435 Flags: Print AppearanceDictionary: true Annotation: Subtype: Link Rect: 405, 425, 548, 435 Flags: Print AppearanceDictionary: true Annotation: Subtype: Link Rect: 405, 425, 548, 435 Flags: Print AppearanceDictionary: true Annotation: Subtype: Link Rect: 50, 705, 168, 713 Page: Label: 2 Annotations: Annotation: Subtype: Link Rect: 106, 716, 116, 726 Flags: Print AppearanceDictionary: true Destination: null Annotation: Subtype: Link Rect: 121, 716, 131, 726 Flags: Print AppearanceDictionary: true Destination: null Annotation: Subtype: Link Rect: 202, 682, 211, 692 Flags: Print AppearanceDictionary: true Destination: null Annotation: Subtype: Link Rect: 217, 682, 227, 692 Flags: Print AppearanceDictionary: true Destination: null Annotation: Subtype: Link Rect: 152, 659, 161, 669 Flags: Print AppearanceDictionary: true Destination: null Annotation: Subtype: Link Rect: 259, 636, 269, 646 Flags: Print AppearanceDictionary: true Destination: null Annotation: Subtype: Link Rect: 275, 636, 285, 646 Flags: Print AppearanceDictionary: true Destination: null Annotation: Subtype: Link Rect: 198, 602, 208, 612 Flags: Print AppearanceDictionary: true Destination: null Annotation: Subtype: Link Rect: 213, 602, 222, 612 Flags: Print AppearanceDictionary: true Destination: null Annotation: Subtype: Link Rect: 207, 591, 216, 601 Flags: Print AppearanceDictionary: true Destination: null Annotation: Subtype: Link Rect: 72, 271, 76, 281 Flags: Print AppearanceDictionary: true Destination: null Annotation: Subtype: Link Rect: 138, 271, 143, 281 Flags: Print AppearanceDictionary: true Destination: null Annotation: Subtype: Link Rect: 202, 203, 211, 213 Flags: Print AppearanceDictionary: true Destination: null Annotation: Subtype: Link Rect: 508, 556, 512, 566 Flags: Print AppearanceDictionary: true Destination: null Annotation: Subtype: Link Rect: 370, 340, 375, 350 Flags: Print AppearanceDictionary: true Destination: null Annotation: Subtype: Link Rect: 336, 123, 341, 133 Flags: Print AppearanceDictionary: true Destination: 203 Annotation: Subtype: Link Rect: 482, 66, 487, 76 Flags: Print AppearanceDictionary: true Destination: null Page: Label: 3 Page: Label: 4 Annotations: Annotation: Subtype: Link Rect: 79, 237, 84, 247 Flags: Print AppearanceDictionary: true Destination: 73 Annotation: Subtype: Link Rect: 167, 146, 171, 156 Flags: Print AppearanceDictionary: true Destination: null Page: Label: 5 Annotations: Annotation: Subtype: Link Rect: 267, 294, 272, 304 Flags: Print AppearanceDictionary: true Destination: null Annotation: Subtype: Link Rect: 194, 78, 203, 88 Flags: Print AppearanceDictionary: true Destination: null Annotation: Subtype: Link Rect: 255, 66, 260, 76 Flags: Print AppearanceDictionary: true Destination: null Annotation: Subtype: Link Rect: 265, 66, 274, 76 Flags: Print AppearanceDictionary: true Destination: null Annotation: Subtype: Link Rect: 241, 55, 250, 65 Flags: Print AppearanceDictionary: true Destination: null Annotation: Subtype: Link Rect: 377, 363, 386, 373 Flags: Print AppearanceDictionary: true Destination: null Annotation: Subtype: Link Rect: 507, 363, 516, 373 Flags: Print AppearanceDictionary: true Destination: null Annotation: Subtype: Link Rect: 354, 340, 364, 350 Flags: Print AppearanceDictionary: true Destination: null Annotation: Subtype: Link Rect: 369, 340, 379, 350 Flags: Print AppearanceDictionary: true Destination: null Annotation: Subtype: Link Rect: 464, 340, 473, 350 Flags: Print AppearanceDictionary: true Destination: null Annotation: Subtype: Link Rect: 479, 340, 488, 350 Flags: Print AppearanceDictionary: true Destination: null Annotation: Subtype: Link Rect: 493, 340, 503, 350 Flags: Print AppearanceDictionary: true Destination: null Annotation: Subtype: Link Rect: 508, 340, 518, 350 Flags: Print AppearanceDictionary: true Destination: null Annotation: Subtype: Link Rect: 399, 317, 408, 327 Flags: Print AppearanceDictionary: true Destination: null Annotation: Subtype: Link Rect: 510, 306, 520, 316 Flags: Print AppearanceDictionary: true Destination: null Annotation: Subtype: Link Rect: 312, 283, 322, 293 Flags: Print AppearanceDictionary: true Destination: null Annotation: Subtype: Link Rect: 373, 237, 378, 247 Flags: Print AppearanceDictionary: true Destination: null Annotation: Subtype: Link Rect: 439, 214, 448, 224 Flags: Print AppearanceDictionary: true Destination: null Annotation: Subtype: Link Rect: 453, 214, 463, 224 Flags: Print AppearanceDictionary: true Destination: null Annotation: Subtype: Link Rect: 397, 192, 406, 202 Flags: Print AppearanceDictionary: true Destination: null Annotation: Subtype: Link Rect: 342, 135, 352, 145 Flags: Print AppearanceDictionary: true Destination: null Annotation: Subtype: Link Rect: 396, 135, 406, 145 Flags: Print AppearanceDictionary: true Destination: null Annotation: Subtype: Link Rect: 312, 123, 322, 133 Flags: Print AppearanceDictionary: true Destination: null Annotation: Subtype: Link Rect: 384, 55, 394, 65 Flags: Print AppearanceDictionary: true Destination: null Annotation: Subtype: Link Rect: 400, 55, 410, 65 Flags: Print AppearanceDictionary: true Destination: null Annotation: Subtype: Link Rect: 416, 55, 426, 65 Flags: Print AppearanceDictionary: true Destination: null Page: Label: 6 Annotations: Annotation: Subtype: Link Rect: 53, 591, 63, 601 Flags: Print AppearanceDictionary: true Destination: null Annotation: Subtype: Link Rect: 277, 556, 287, 566 Flags: Print AppearanceDictionary: true Destination: null Annotation: Subtype: Link Rect: 53, 465, 63, 475 Flags: Print AppearanceDictionary: true Destination: null Annotation: Subtype: Link Rect: 122, 454, 127, 464 Flags: Print AppearanceDictionary: true Destination: null Annotation: Subtype: Link Rect: 53, 442, 63, 452 Flags: Print AppearanceDictionary: true Destination: null Annotation: Subtype: Link Rect: 111, 385, 115, 395 Flags: Print AppearanceDictionary: true Destination: 203 Annotation: Subtype: Link Rect: 113, 374, 123, 384 Flags: Print AppearanceDictionary: true Destination: null Annotation: Subtype: Link Rect: 53, 260, 63, 270 Flags: Print AppearanceDictionary: true Destination: null Annotation: Subtype: Link Rect: 277, 249, 287, 259 Flags: Print AppearanceDictionary: true Destination: null Annotation: Subtype: Link Rect: 180, 169, 189, 179 Flags: Print AppearanceDictionary: true Destination: null Annotation: Subtype: Link Rect: 199, 157, 208, 167 Flags: Print AppearanceDictionary: true Destination: null Annotation: Subtype: Link Rect: 228, 146, 238, 156 Flags: Print AppearanceDictionary: true Destination: null Annotation: Subtype: Link Rect: 53, 135, 63, 145 Flags: Print AppearanceDictionary: true Destination: null Annotation: Subtype: Link Rect: 494, 659, 504, 669 Flags: Print AppearanceDictionary: true Destination: null Annotation: Subtype: Link Rect: 444, 636, 449, 646 Flags: Print AppearanceDictionary: true Destination: null Annotation: Subtype: Link Rect: 534, 591, 544, 601 Flags: Print AppearanceDictionary: true Destination: null Annotation: Subtype: Link Rect: 430, 568, 439, 578 Flags: Print AppearanceDictionary: true Destination: null Annotation: Subtype: Link Rect: 388, 465, 397, 475 Flags: Print AppearanceDictionary: true Destination: null Annotation: Subtype: Link Rect: 423, 454, 433, 464 Flags: Print AppearanceDictionary: true Destination: null Annotation: Subtype: Link Rect: 341, 431, 350, 441 Flags: Print AppearanceDictionary: true Destination: null Annotation: Subtype: Link Rect: 480, 431, 489, 441 Flags: Print AppearanceDictionary: true Destination: null Annotation: Subtype: Link Rect: 497, 431, 507, 441 Flags: Print AppearanceDictionary: true Destination: null Annotation: Subtype: Link Rect: 339, 408, 348, 418 Flags: Print AppearanceDictionary: true Destination: null Annotation: Subtype: Link Rect: 354, 408, 364, 418 Flags: Print AppearanceDictionary: true Destination: null Annotation: Subtype: Link Rect: 377, 328, 387, 338 Flags: Print AppearanceDictionary: true Destination: null Annotation: Subtype: Link Rect: 392, 328, 401, 338 Flags: Print AppearanceDictionary: true Destination: null Page: Label: 7 Annotations: Annotation: Subtype: Link Rect: 109, 378, 211, 388 Flags: Print AppearanceDictionary: true Page: Label: 8 Page: Label: 9 Checksum: cf5daed9 Type: CRC32 Checksum: 8f8930375555d744b0a74ddd8d106190 Type: MD5 Checksum: f3a49826fb038d493d2931a60aa376f55af4a522 Type: SHA-1