0209e3c8c67d155190c95245e9232aaf fromic_a2019m1v9p3332.pdf ce2da7c08cbb42484f1f56f5f678dcd327b97076 fromic_a2019m1v9p3332.pdf 2afae61c62b318edfa115f6da514a6398d9b546d01598abbd97bd8d4f6552bf5 fromic_a2019m1v9p3332.pdf Title: Origin of the Mobile Di-Hydro-Pteroate Synthase Gene Determining Sulfonamide Resistance in Clinical Isolates Subject: Sulfonamides are synthetic chemotherapeutic agents that work as competitive inhibitors of the di-hydro-pteroate synthase (DHPS) enzyme, encoded by the folP gene. Keywords: sulfonamide, resistance, antibiotic, phylogeny, mobile element, integron, plasmid Author: Jordi Barbé and Ivan Erill Creator: LaTeX with hyperref package Producer: pdfTeX-1.40.15 CreationDate: Sat Jan 5 13:54:41 2019 CET ModDate: Sat Jan 5 13:54:41 2019 CET Tagged: no UserProperties: no Suspects: no Form: none JavaScript: no Pages: 15 Encrypted: no Page size: 595.276 x 779.528 pts Page rot: 0 File size: 6896492 bytes Optimized: no PDF version: 1.5 name type encoding emb sub uni object ID ------------------------------------ ----------------- ---------------- --- --- --- --------- GVQMKF+MinionPro-Regular Type 1 Custom yes yes no 28 0 VJUVBW+HelveticaNeueLTStd-Bd Type 1 Custom yes yes no 29 0 RAUFON+HelveticaNeueLTStd-Lt Type 1 Custom yes yes no 30 0 RWVGQN+HelveticaNeueLTStd-BdIt Type 1 Custom yes yes no 35 0 QWSCAJ+HelveticaNeueLTStd-LtIt Type 1 Custom yes yes no 36 0 SOQVAS+HelveticaNeueLTStd-MdIt Type 1 Custom yes yes no 37 0 PTBZMW+MinionPro-It Type 1 Custom yes yes no 132 0 VXWSEY+RBLMI Type 1 Builtin yes yes no 134 0 GIJWPJ+MTSYN Type 1 Builtin yes yes no 218 0 FQWPPP+MinionPro-Bold Type 1 Custom yes yes no 219 0 QHWLRN+MTGU Type 1 Builtin yes yes no 297 0 Jhove (Rel. 1.22.1, 2019-04-17) Date: 2021-04-08 02:50:47 CEST RepresentationInformation: fromic_a2019m1v9p3332.pdf ReportingModule: PDF-hul, Rel. 1.12.1 (2019-04-17) LastModified: 2021-04-07 19:37:12 CEST Size: 6896492 Format: PDF Version: 1.5 Status: Well-Formed and valid SignatureMatches: PDF-hul MIMEtype: application/pdf PDFMetadata: Objects: 923 FreeObjects: 6 IncrementalUpdates: 0 DocumentCatalog: PageLayout: SinglePage PageMode: UseOutlines Outlines: Item: Title: Origin of the Mobile Di-Hydro-Pteroate Synthase Gene Determining Sulfonamide Resistance in Clinical Isolates Children: Item: Title: Introduction Item: Title: Materials and Methods Children: Item: Title: Data Collection Item: Title: Identification and Visualization of Sul-Like Signatures in FolP Sequences Item: Title: Multiple Sequence Alignment and Phylogenetic Inference Item: Title: DNA Sequence Analyses Item: Title: Cloning, Transformation and Complementation of the folP Gene for Broth Microdilution Assays Item: Title: Results Children: Item: Title: Identification of Putative Chromosomal Origins for sul1-3 Genes Item: Title: Phylogenetic Analysis of sul/folP and glmM Genes Item: Title: Analysis of sul/folP and glmM Gene Sequences Item: Title: Sulfonamide Resistance of Chromosomal folP Genes Item: Title: Discussion Children: Item: Title: Prevalence of Sulfonamide Resistance in Ancestral Bacteria Item: Title: Mobilization of Ancestral Resistance Reservoirs Item: Title: Data Availability Statement Item: Title: Author Contributions Item: Title: Funding Item: Title: Acknowledgments Item: Title: Supplementary Material Item: Title: References Info: Title: Origin of the Mobile Di-Hydro-Pteroate Synthase Gene Determining Sulfonamide Resistance in Clinical Isolates Author: Jordi Barbé and Ivan Erill Subject: Sulfonamides are synthetic chemotherapeutic agents that work as competitive inhibitors of the di-hydro-pteroate synthase (DHPS) enzyme, encoded by the folP gene. Keywords: sulfonamide, resistance, antibiotic, phylogeny, mobile element, integron, plasmid Creator: LaTeX with hyperref package Producer: pdfTeX-1.40.15 CreationDate: Sat Jan 05 14:24:41 CET 2019 ModDate: Sat Jan 05 14:24:41 CET 2019 ID: 0x6eabefd58b55acc475cfed161ec22ae6, 0x6eabefd58b55acc475cfed161ec22ae6 Filters: FilterPipeline: FlateDecode Fonts: Type1: Font: BaseFont: RWVGQN+HelveticaNeueLTStd-BdIt FontSubset: true FirstChar: 42 LastChar: 121 FontDescriptor: FontName: RWVGQN+HelveticaNeueLTStd-BdIt Flags: Symbolic FontBBox: -166, -218, 1129, 975 FontFile: true EncodingDictionary: Differences: true Font: BaseFont: QWSCAJ+HelveticaNeueLTStd-LtIt FontSubset: true FirstChar: 2 LastChar: 248 FontDescriptor: FontName: QWSCAJ+HelveticaNeueLTStd-LtIt Flags: Symbolic FontBBox: -165, -214, 1099, 951 FontFile: true EncodingDictionary: Differences: true Font: BaseFont: PTBZMW+MinionPro-It FontSubset: true FirstChar: 19 LastChar: 233 FontDescriptor: FontName: PTBZMW+MinionPro-It Flags: Symbolic FontBBox: -201, -360, 1684, 919 FontFile: true EncodingDictionary: Differences: true Font: BaseFont: SOQVAS+HelveticaNeueLTStd-MdIt FontSubset: true FirstChar: 42 LastChar: 233 FontDescriptor: FontName: SOQVAS+HelveticaNeueLTStd-MdIt Flags: Symbolic FontBBox: -165, -218, 1125, 947 FontFile: true EncodingDictionary: Differences: true Font: BaseFont: VXWSEY+RBLMI FontSubset: true FirstChar: 49 LastChar: 62 FontDescriptor: FontName: VXWSEY+RBLMI Flags: Symbolic FontBBox: -11, -230, 987, 750 FontFile: true Font: BaseFont: QHWLRN+MTGU FontSubset: true FirstChar: 97 LastChar: 109 FontDescriptor: FontName: QHWLRN+MTGU Flags: Symbolic FontBBox: 25, -213, 839, 683 FontFile: true Font: BaseFont: GIJWPJ+MTSYN FontSubset: true FirstChar: 0 LastChar: 14 FontDescriptor: FontName: GIJWPJ+MTSYN Flags: Symbolic FontBBox: 0, -954, 1043, 900 FontFile: true Font: BaseFont: FQWPPP+MinionPro-Bold FontSubset: true FirstChar: 3 LastChar: 150 FontDescriptor: FontName: FQWPPP+MinionPro-Bold Flags: Symbolic FontBBox: -318, -360, 1684, 917 FontFile: true EncodingDictionary: Differences: true Font: BaseFont: GVQMKF+MinionPro-Regular FontSubset: true FirstChar: 2 LastChar: 250 FontDescriptor: FontName: GVQMKF+MinionPro-Regular Flags: Symbolic FontBBox: -289, -360, 1684, 917 FontFile: true EncodingDictionary: Differences: true Font: BaseFont: VJUVBW+HelveticaNeueLTStd-Bd FontSubset: true FirstChar: 2 LastChar: 124 FontDescriptor: FontName: VJUVBW+HelveticaNeueLTStd-Bd Flags: Symbolic FontBBox: -166, -218, 1078, 975 FontFile: true EncodingDictionary: Differences: true Font: BaseFont: RAUFON+HelveticaNeueLTStd-Lt FontSubset: true FirstChar: 2 LastChar: 225 FontDescriptor: FontName: RAUFON+HelveticaNeueLTStd-Lt Flags: Symbolic FontBBox: -166, -214, 1050, 967 FontFile: true EncodingDictionary: Differences: true XMP: sulfonamide, resistance, antibiotic, phylogeny, mobile element, integron, plasmid pdfTeX-1.40.15 1.5 application/pdf Origin of the Mobile Di-Hydro-Pteroate Synthase Gene Determining Sulfonamide Resistance in Clinical Isolates Sulfonamides are synthetic chemotherapeutic agents that work as competitive inhibitors of the di-hydro-pteroate synthase (DHPS) enzyme, encoded by the folP gene. Jordi Barbé and Ivan Erill sulfonamide resistance antibiotic phylogeny mobile element integron plasmid 2019-01-05T18:24:41+05:30 fmicb-09-03332.tex 2019-01-05T18:24:41+05:30 2019-01-05T18:24:41+05:30 2019-01-05T18:24:41+05:30 LaTeX with hyperref package uuid:efd1dce4-6c95-4900-99bb-62bb620aefdc uuid:0a333ef2-6c90-40ae-a39b-b1390a3ef20a Pages: Page: Sequence: 1 Annotations: Annotation: Subtype: Link Rect: 43, 718, 160, 754 Annotation: Subtype: Link Rect: 474, 736, 551, 745 Annotation: Subtype: Link Rect: 465, 727, 551, 737 Annotation: Subtype: Link Rect: 453, 718, 551, 729 Annotation: Subtype: Link Rect: 86, 422, 160, 432 Annotation: Subtype: Link Rect: 75, 67, 160, 74 Annotation: Subtype: Link Rect: 521, 677, 551, 707 Annotation: Subtype: Link Rect: 176, 513, 551, 603 Annotation: Subtype: Link Rect: 176, 489, 274, 502 Annotation: Subtype: Link Rect: 281, 489, 332, 502 Annotation: Subtype: Link Rect: 338, 489, 389, 502 Annotation: Subtype: Link Rect: 415, 489, 452, 502 Annotation: Subtype: Link Rect: 43, 29, 119, 38 Annotation: Subtype: Link Rect: 122, 29, 182, 38 Annotation: Subtype: Link Rect: 433, 29, 551, 38 Page: Sequence: 2 Annotations: Annotation: Subtype: Link Rect: 47, 672, 100, 683 ActionDest: 665 Annotation: Subtype: Link Rect: 106, 672, 127, 683 ActionDest: 665 Annotation: Subtype: Link Rect: 133, 672, 198, 683 ActionDest: 735 Annotation: Subtype: Link Rect: 204, 672, 225, 683 ActionDest: 735 Annotation: Subtype: Link Rect: 152, 626, 232, 637 ActionDest: 665 Annotation: Subtype: Link Rect: 238, 626, 258, 637 ActionDest: 665 Annotation: Subtype: Link Rect: 172, 568, 243, 580 ActionDest: 665 Annotation: Subtype: Link Rect: 246, 568, 266, 580 ActionDest: 665 Annotation: Subtype: Link Rect: 238, 523, 292, 534 ActionDest: 665 Annotation: Subtype: Link Rect: 43, 511, 73, 522 ActionDest: 665 Annotation: Subtype: Link Rect: 80, 511, 100, 522 ActionDest: 665 Annotation: Subtype: Link Rect: 259, 454, 292, 465 ActionDest: 665 Annotation: Subtype: Link Rect: 43, 442, 91, 454 ActionDest: 665 Annotation: Subtype: Link Rect: 94, 442, 114, 454 ActionDest: 665 Annotation: Subtype: Link Rect: 47, 362, 78, 374 ActionDest: 735 Annotation: Subtype: Link Rect: 81, 362, 101, 374 ActionDest: 735 Annotation: Subtype: Link Rect: 222, 282, 290, 293 ActionDest: 776 Annotation: Subtype: Link Rect: 43, 271, 64, 282 ActionDest: 776 Annotation: Subtype: Link Rect: 47, 179, 70, 190 ActionDest: 735 Annotation: Subtype: Link Rect: 73, 179, 93, 190 ActionDest: 735 Annotation: Subtype: Link Rect: 195, 156, 240, 167 ActionDest: 735 Annotation: Subtype: Link Rect: 243, 156, 263, 167 ActionDest: 735 Annotation: Subtype: Link Rect: 267, 156, 290, 167 ActionDest: 735 Annotation: Subtype: Link Rect: 43, 145, 64, 156 ActionDest: 735 Annotation: Subtype: Link Rect: 98, 110, 133, 121 ActionDest: 665 Annotation: Subtype: Link Rect: 138, 110, 158, 121 ActionDest: 665 Annotation: Subtype: Link Rect: 163, 110, 196, 121 ActionDest: 665 Annotation: Subtype: Link Rect: 201, 110, 222, 121 ActionDest: 665 Annotation: Subtype: Link Rect: 267, 76, 290, 87 ActionDest: 735 Annotation: Subtype: Link Rect: 43, 64, 64, 76 ActionDest: 735 Annotation: Subtype: Link Rect: 66, 64, 109, 76 ActionDest: 665 Annotation: Subtype: Link Rect: 111, 64, 132, 76 ActionDest: 665 Annotation: Subtype: Link Rect: 449, 694, 495, 706 ActionDest: 735 Annotation: Subtype: Link Rect: 497, 694, 517, 706 ActionDest: 735 Annotation: Subtype: Link Rect: 486, 671, 549, 683 ActionDest: 735 Annotation: Subtype: Link Rect: 302, 660, 322, 671 ActionDest: 735 Annotation: Subtype: Link Rect: 327, 660, 350, 671 ActionDest: 735 Annotation: Subtype: Link Rect: 355, 660, 375, 671 ActionDest: 735 Annotation: Subtype: Link Rect: 375, 614, 398, 626 ActionDest: 735 Annotation: Subtype: Link Rect: 401, 614, 421, 626 ActionDest: 735 Annotation: Subtype: Link Rect: 458, 591, 481, 603 ActionDest: 735 Annotation: Subtype: Link Rect: 485, 591, 505, 603 ActionDest: 735 Annotation: Subtype: Link Rect: 340, 557, 399, 568 ActionDest: 735 Annotation: Subtype: Link Rect: 402, 557, 422, 568 ActionDest: 735 Annotation: Subtype: Link Rect: 424, 557, 477, 568 ActionDest: 665 Annotation: Subtype: Link Rect: 479, 557, 500, 568 ActionDest: 665 Annotation: Subtype: Link Rect: 346, 534, 396, 545 ActionDest: 665 Annotation: Subtype: Link Rect: 398, 534, 418, 545 ActionDest: 665 Annotation: Subtype: Link Rect: 421, 534, 479, 545 ActionDest: 735 Annotation: Subtype: Link Rect: 482, 534, 502, 545 ActionDest: 735 Annotation: Subtype: Link Rect: 305, 477, 329, 488 ActionDest: 735 Annotation: Subtype: Link Rect: 333, 477, 353, 488 ActionDest: 735 Annotation: Subtype: Link Rect: 335, 454, 394, 465 ActionDest: 735 Annotation: Subtype: Link Rect: 396, 454, 416, 465 ActionDest: 735 Annotation: Subtype: Link Rect: 511, 442, 551, 454 ActionDest: 735 Annotation: Subtype: Link Rect: 302, 431, 322, 442 ActionDest: 735 Annotation: Subtype: Link Rect: 324, 431, 344, 442 ActionDest: 735 Annotation: Subtype: Link Rect: 423, 419, 469, 431 ActionDest: 665 Annotation: Subtype: Link Rect: 474, 419, 494, 431 ActionDest: 665 Annotation: Subtype: Link Rect: 445, 408, 499, 419 ActionDest: 776 Annotation: Subtype: Link Rect: 505, 408, 525, 419 ActionDest: 776 Annotation: Subtype: Link Rect: 438, 362, 522, 373 ActionDest: 735 Annotation: Subtype: Link Rect: 525, 362, 545, 373 ActionDest: 735 Annotation: Subtype: Link Rect: 337, 282, 384, 293 ActionDest: 735 Annotation: Subtype: Link Rect: 387, 282, 407, 293 ActionDest: 735 Annotation: Subtype: Link Rect: 43, 29, 119, 38 Annotation: Subtype: Link Rect: 122, 29, 182, 38 Annotation: Subtype: Link Rect: 433, 29, 551, 38 Page: Sequence: 3 Annotations: Annotation: Subtype: Link Rect: 177, 657, 252, 668 Annotation: Subtype: Link Rect: 132, 646, 207, 657 Annotation: Subtype: Link Rect: 222, 646, 290, 657 ActionDest: 665 Annotation: Subtype: Link Rect: 43, 634, 64, 645 ActionDest: 665 Annotation: Subtype: Link Rect: 200, 565, 275, 577 Annotation: Subtype: Link Rect: 98, 508, 196, 519 ActionDest: 665 Annotation: Subtype: Link Rect: 87, 463, 162, 474 Annotation: Subtype: Link Rect: 43, 389, 118, 401 Annotation: Subtype: Link Rect: 179, 332, 254, 343 Annotation: Subtype: Link Rect: 262, 332, 292, 343 ActionDest: 665 Annotation: Subtype: Link Rect: 43, 321, 65, 332 ActionDest: 665 Annotation: Subtype: Link Rect: 69, 321, 90, 332 ActionDest: 665 Annotation: Subtype: Link Rect: 212, 309, 287, 320 Annotation: Subtype: Link Rect: 214, 287, 289, 298 Annotation: Subtype: Link Rect: 83, 263, 158, 275 Annotation: Subtype: Link Rect: 43, 122, 118, 133 Annotation: Subtype: Link Rect: 129, 122, 200, 133 ActionDest: 735 Annotation: Subtype: Link Rect: 206, 122, 227, 133 ActionDest: 735 Annotation: Subtype: Link Rect: 135, 88, 210, 99 Annotation: Subtype: Link Rect: 219, 88, 290, 99 ActionDest: 735 Annotation: Subtype: Link Rect: 43, 76, 64, 87 ActionDest: 735 Annotation: Subtype: Link Rect: 339, 707, 382, 717 ActionDest: 665 Annotation: Subtype: Link Rect: 384, 707, 405, 717 ActionDest: 665 Annotation: Subtype: Link Rect: 412, 706, 478, 717 ActionDest: 665 Annotation: Subtype: Link Rect: 485, 706, 505, 717 ActionDest: 665 Annotation: Subtype: Link Rect: 409, 683, 484, 694 Annotation: Subtype: Link Rect: 494, 683, 551, 694 ActionDest: 735 Annotation: Subtype: Link Rect: 302, 672, 353, 683 ActionDest: 735 Annotation: Subtype: Link Rect: 358, 672, 378, 683 ActionDest: 735 Annotation: Subtype: Link Rect: 419, 637, 494, 648 Annotation: Subtype: Link Rect: 473, 577, 549, 588 ActionDest: 735 Annotation: Subtype: Link Rect: 302, 565, 322, 576 ActionDest: 735 Annotation: Subtype: Link Rect: 351, 554, 406, 565 ActionDest: 735 Annotation: Subtype: Link Rect: 410, 554, 430, 565 ActionDest: 735 Annotation: Subtype: Link Rect: 302, 463, 377, 473 Annotation: Subtype: Link Rect: 347, 359, 448, 370 ActionDest: 735 Annotation: Subtype: Link Rect: 456, 359, 477, 370 ActionDest: 735 Annotation: Subtype: Link Rect: 339, 302, 414, 313 Annotation: Subtype: Link Rect: 421, 302, 480, 313 ActionDest: 665 Annotation: Subtype: Link Rect: 482, 302, 502, 313 ActionDest: 665 Annotation: Subtype: Link Rect: 353, 279, 415, 290 ActionDest: 665 Annotation: Subtype: Link Rect: 417, 279, 438, 290 ActionDest: 665 Annotation: Subtype: Link Rect: 458, 133, 493, 144 ActionDest: 735 Annotation: Subtype: Link Rect: 498, 133, 518, 144 ActionDest: 735 Annotation: Subtype: Link Rect: 522, 133, 551, 144 ActionDest: 735 Annotation: Subtype: Link Rect: 302, 122, 323, 133 ActionDest: 735 Annotation: Subtype: Link Rect: 327, 122, 347, 133 ActionDest: 735 Annotation: Subtype: Link Rect: 462, 110, 551, 121 ActionDest: 665 Annotation: Subtype: Link Rect: 302, 99, 314, 110 ActionDest: 665 Annotation: Subtype: Link Rect: 453, 87, 528, 99 Annotation: Subtype: Link Rect: 497, 76, 549, 87 ActionDest: 735 Annotation: Subtype: Link Rect: 302, 64, 322, 76 ActionDest: 735 Annotation: Subtype: Link Rect: 43, 29, 119, 38 Annotation: Subtype: Link Rect: 122, 29, 182, 38 Annotation: Subtype: Link Rect: 433, 29, 551, 38 Page: Sequence: 4 Annotations: Annotation: Subtype: Link Rect: 212, 683, 287, 694 Annotation: Subtype: Link Rect: 136, 671, 211, 683 Annotation: Subtype: Link Rect: 43, 649, 118, 660 Annotation: Subtype: Link Rect: 81, 637, 156, 648 Annotation: Subtype: Link Rect: 187, 591, 292, 603 ActionDest: 665 Annotation: Subtype: Link Rect: 43, 580, 122, 591 ActionDest: 665 Annotation: Subtype: Link Rect: 127, 580, 148, 591 ActionDest: 665 Annotation: Subtype: Link Rect: 43, 478, 118, 488 Annotation: Subtype: Link Rect: 230, 339, 273, 351 ActionDest: 326 Annotation: Subtype: Link Rect: 43, 328, 143, 339 ActionDest: 665 Annotation: Subtype: Link Rect: 238, 248, 292, 259 ActionDest: 326 Annotation: Subtype: Link Rect: 62, 236, 157, 247 ActionDest: 665 Annotation: Subtype: Link Rect: 166, 236, 265, 247 ActionDest: 735 Annotation: Subtype: Link Rect: 270, 236, 290, 247 ActionDest: 735 Annotation: Subtype: Link Rect: 43, 225, 100, 236 ActionDest: 735 Annotation: Subtype: Link Rect: 105, 225, 125, 236 ActionDest: 735 Annotation: Subtype: Link Rect: 92, 213, 167, 225 Annotation: Subtype: Link Rect: 178, 213, 275, 225 ActionDest: 665 Annotation: Subtype: Link Rect: 156, 190, 231, 202 Annotation: Subtype: Link Rect: 43, 168, 118, 179 Annotation: Subtype: Link Rect: 218, 145, 289, 156 Annotation: Subtype: Link Rect: 81, 76, 180, 87 ActionDest: 665 Annotation: Subtype: Link Rect: 473, 660, 548, 671 Annotation: Subtype: Link Rect: 343, 626, 442, 637 ActionDest: 665 Annotation: Subtype: Link Rect: 398, 545, 494, 557 ActionDest: 735 Annotation: Subtype: Link Rect: 498, 545, 518, 557 ActionDest: 735 Annotation: Subtype: Link Rect: 504, 511, 551, 522 ActionDest: 735 Annotation: Subtype: Link Rect: 302, 500, 353, 511 ActionDest: 735 Annotation: Subtype: Link Rect: 356, 500, 376, 511 ActionDest: 735 Annotation: Subtype: Link Rect: 379, 500, 414, 511 ActionDest: 735 Annotation: Subtype: Link Rect: 417, 500, 437, 511 ActionDest: 735 Annotation: Subtype: Link Rect: 461, 465, 506, 477 ActionDest: 326 Annotation: Subtype: Link Rect: 305, 397, 347, 408 ActionDest: 326 Annotation: Subtype: Link Rect: 305, 213, 347, 225 ActionDest: 326 Annotation: Subtype: Link Rect: 43, 29, 119, 38 Annotation: Subtype: Link Rect: 122, 29, 182, 38 Annotation: Subtype: Link Rect: 433, 29, 551, 38 Page: Sequence: 5 Annotations: Annotation: Subtype: Link Rect: 0, 286, 1, 299 ActionDest: 5 Annotation: Subtype: Link Rect: 0, 286, 1, 299 ActionDest: 5 Annotation: Subtype: Link Rect: 43, 133, 118, 145 Annotation: Subtype: Link Rect: 43, 110, 118, 122 Annotation: Subtype: Link Rect: 47, 88, 139, 99 ActionDest: 665 Annotation: Subtype: Link Rect: 302, 179, 377, 190 Annotation: Subtype: Link Rect: 473, 179, 548, 190 Annotation: Subtype: Link Rect: 305, 168, 396, 179 ActionDest: 665 Annotation: Subtype: Link Rect: 394, 156, 431, 168 ActionDest: 362 Annotation: Subtype: Link Rect: 43, 29, 119, 38 Annotation: Subtype: Link Rect: 122, 29, 182, 38 Annotation: Subtype: Link Rect: 433, 29, 551, 38 Page: Sequence: 6 Annotations: Annotation: Subtype: Link Rect: 146, 397, 197, 408 ActionDest: 735 Annotation: Subtype: Link Rect: 200, 397, 220, 408 ActionDest: 735 Annotation: Subtype: Link Rect: 175, 305, 268, 316 ActionDest: 665 Annotation: Subtype: Link Rect: 131, 248, 185, 259 ActionDest: 326 Annotation: Subtype: Link Rect: 254, 156, 289, 168 ActionDest: 389 Annotation: Subtype: Link Rect: 435, 317, 477, 328 ActionDest: 326 Annotation: Subtype: Link Rect: 305, 156, 344, 167 ActionDest: 362 Annotation: Subtype: Link Rect: 385, 122, 428, 133 ActionDest: 326 Annotation: Subtype: Link Rect: 488, 110, 551, 121 ActionDest: 665 Annotation: Subtype: Link Rect: 302, 99, 332, 110 ActionDest: 665 Annotation: Subtype: Link Rect: 305, 64, 404, 76 ActionDest: 665 Annotation: Subtype: Link Rect: 506, 64, 548, 76 ActionDest: 427 Annotation: Subtype: Link Rect: 43, 29, 119, 38 Annotation: Subtype: Link Rect: 122, 29, 182, 38 Annotation: Subtype: Link Rect: 433, 29, 551, 38 Page: Sequence: 7 Annotations: Annotation: Subtype: Link Rect: 47, 202, 81, 213 ActionDest: 446 Annotation: Subtype: Link Rect: 234, 168, 267, 179 ActionDest: 446 Annotation: Subtype: Link Rect: 165, 133, 225, 145 ActionDest: 735 Annotation: Subtype: Link Rect: 228, 133, 249, 145 ActionDest: 735 Annotation: Subtype: Link Rect: 366, 202, 407, 213 ActionDest: 427 Annotation: Subtype: Link Rect: 413, 202, 511, 213 ActionDest: 665 Annotation: Subtype: Link Rect: 355, 192, 446, 202 ActionDest: 735 Annotation: Subtype: Link Rect: 449, 192, 469, 202 ActionDest: 735 Annotation: Subtype: Link Rect: 43, 29, 119, 38 Annotation: Subtype: Link Rect: 122, 29, 182, 38 Annotation: Subtype: Link Rect: 433, 29, 551, 38 Page: Sequence: 8 Annotations: Annotation: Subtype: Link Rect: 47, 76, 146, 87 ActionDest: 665 Annotation: Subtype: Link Rect: 131, 65, 183, 76 ActionDest: 735 Annotation: Subtype: Link Rect: 186, 65, 206, 76 ActionDest: 735 Annotation: Subtype: Link Rect: 420, 111, 456, 122 ActionDest: 362 Annotation: Subtype: Link Rect: 363, 99, 393, 110 ActionDest: 446 Annotation: Subtype: Link Rect: 43, 29, 119, 38 Annotation: Subtype: Link Rect: 122, 29, 182, 38 Annotation: Subtype: Link Rect: 433, 29, 551, 38 Page: Sequence: 9 Annotations: Annotation: Subtype: Link Rect: 47, 248, 224, 259 ActionDest: 665 Annotation: Subtype: Link Rect: 229, 248, 249, 259 ActionDest: 665 Annotation: Subtype: Link Rect: 87, 216, 120, 225 ActionDest: 525 Annotation: Subtype: Link Rect: 47, 156, 123, 167 ActionDest: 665 Annotation: Subtype: Link Rect: 129, 156, 149, 167 ActionDest: 665 Annotation: Subtype: Link Rect: 154, 156, 174, 167 ActionDest: 665 Annotation: Subtype: Link Rect: 180, 156, 261, 167 ActionDest: 776 Annotation: Subtype: Link Rect: 267, 156, 287, 167 ActionDest: 776 Annotation: Subtype: Link Rect: 375, 379, 405, 390 ActionDest: 525 Annotation: Subtype: Link Rect: 337, 356, 397, 367 ActionDest: 665 Annotation: Subtype: Link Rect: 403, 356, 423, 367 ActionDest: 665 Annotation: Subtype: Link Rect: 428, 356, 470, 367 ActionDest: 665 Annotation: Subtype: Link Rect: 476, 356, 496, 367 ActionDest: 665 Annotation: Subtype: Link Rect: 502, 356, 551, 367 ActionDest: 735 Annotation: Subtype: Link Rect: 302, 344, 332, 356 ActionDest: 735 Annotation: Subtype: Link Rect: 336, 344, 356, 356 ActionDest: 735 Annotation: Subtype: Link Rect: 360, 344, 407, 356 ActionDest: 735 Annotation: Subtype: Link Rect: 411, 344, 431, 356 ActionDest: 735 Annotation: Subtype: Link Rect: 403, 310, 441, 321 ActionDest: 362 Annotation: Subtype: Link Rect: 511, 253, 551, 264 ActionDest: 735 Annotation: Subtype: Link Rect: 302, 241, 358, 252 ActionDest: 735 Annotation: Subtype: Link Rect: 362, 241, 382, 252 ActionDest: 735 Annotation: Subtype: Link Rect: 385, 241, 440, 252 ActionDest: 735 Annotation: Subtype: Link Rect: 443, 241, 463, 252 ActionDest: 735 Annotation: Subtype: Link Rect: 499, 207, 549, 218 ActionDest: 665 Annotation: Subtype: Link Rect: 302, 196, 322, 207 ActionDest: 665 Annotation: Subtype: Link Rect: 449, 76, 484, 87 ActionDest: 551 Annotation: Subtype: Link Rect: 43, 29, 119, 38 Annotation: Subtype: Link Rect: 122, 29, 182, 38 Annotation: Subtype: Link Rect: 433, 29, 551, 38 Page: Sequence: 10 Annotations: Annotation: Subtype: Link Rect: 47, 465, 111, 477 ActionDest: 665 Annotation: Subtype: Link Rect: 113, 465, 133, 477 ActionDest: 665 Annotation: Subtype: Link Rect: 47, 339, 140, 351 ActionDest: 735 Annotation: Subtype: Link Rect: 146, 339, 166, 351 ActionDest: 735 Annotation: Subtype: Link Rect: 111, 305, 159, 316 ActionDest: 776 Annotation: Subtype: Link Rect: 165, 305, 186, 316 ActionDest: 776 Annotation: Subtype: Link Rect: 215, 282, 263, 293 ActionDest: 735 Annotation: Subtype: Link Rect: 267, 282, 287, 293 ActionDest: 735 Annotation: Subtype: Link Rect: 138, 248, 218, 259 ActionDest: 735 Annotation: Subtype: Link Rect: 222, 248, 243, 259 ActionDest: 735 Annotation: Subtype: Link Rect: 162, 213, 192, 225 ActionDest: 665 Annotation: Subtype: Link Rect: 197, 213, 217, 225 ActionDest: 665 Annotation: Subtype: Link Rect: 226, 213, 259, 225 ActionDest: 446 Annotation: Subtype: Link Rect: 195, 168, 249, 179 ActionDest: 665 Annotation: Subtype: Link Rect: 254, 168, 275, 179 ActionDest: 665 Annotation: Subtype: Link Rect: 103, 144, 190, 156 ActionDest: 665 Annotation: Subtype: Link Rect: 196, 144, 216, 156 ActionDest: 665 Annotation: Subtype: Link Rect: 103, 122, 145, 133 ActionDest: 735 Annotation: Subtype: Link Rect: 149, 122, 169, 133 ActionDest: 735 Annotation: Subtype: Link Rect: 96, 87, 120, 99 ActionDest: 735 Annotation: Subtype: Link Rect: 123, 87, 143, 99 ActionDest: 735 Annotation: Subtype: Link Rect: 428, 649, 495, 660 ActionDest: 735 Annotation: Subtype: Link Rect: 500, 649, 520, 660 ActionDest: 735 Annotation: Subtype: Link Rect: 525, 649, 549, 660 ActionDest: 735 Annotation: Subtype: Link Rect: 302, 637, 322, 648 ActionDest: 735 Annotation: Subtype: Link Rect: 525, 626, 549, 637 ActionDest: 735 Annotation: Subtype: Link Rect: 302, 614, 322, 626 ActionDest: 735 Annotation: Subtype: Link Rect: 402, 592, 448, 603 ActionDest: 665 Annotation: Subtype: Link Rect: 452, 592, 472, 603 ActionDest: 665 Annotation: Subtype: Link Rect: 477, 557, 523, 568 ActionDest: 665 Annotation: Subtype: Link Rect: 528, 557, 549, 568 ActionDest: 665 Annotation: Subtype: Link Rect: 302, 545, 361, 557 ActionDest: 735 Annotation: Subtype: Link Rect: 366, 545, 386, 557 ActionDest: 735 Annotation: Subtype: Link Rect: 355, 478, 398, 488 ActionDest: 665 Annotation: Subtype: Link Rect: 401, 478, 421, 488 ActionDest: 665 Annotation: Subtype: Link Rect: 381, 419, 451, 431 ActionDest: 735 Annotation: Subtype: Link Rect: 458, 419, 478, 431 ActionDest: 735 Annotation: Subtype: Link Rect: 333, 374, 388, 385 ActionDest: 665 Annotation: Subtype: Link Rect: 390, 374, 410, 385 ActionDest: 665 Annotation: Subtype: Link Rect: 493, 339, 549, 351 ActionDest: 665 Annotation: Subtype: Link Rect: 302, 329, 322, 339 ActionDest: 665 Annotation: Subtype: Link Rect: 415, 190, 451, 202 ActionDest: 551 Annotation: Subtype: Link Rect: 518, 156, 551, 167 ActionDest: 665 Annotation: Subtype: Link Rect: 302, 144, 349, 156 ActionDest: 665 Annotation: Subtype: Link Rect: 352, 144, 373, 156 ActionDest: 665 Annotation: Subtype: Link Rect: 376, 144, 452, 156 ActionDest: 735 Annotation: Subtype: Link Rect: 456, 144, 476, 156 ActionDest: 735 Annotation: Subtype: Link Rect: 507, 77, 551, 87 ActionDest: 735 Annotation: Subtype: Link Rect: 302, 64, 334, 76 ActionDest: 735 Annotation: Subtype: Link Rect: 336, 64, 357, 76 ActionDest: 735 Annotation: Subtype: Link Rect: 43, 29, 119, 38 Annotation: Subtype: Link Rect: 122, 29, 182, 38 Annotation: Subtype: Link Rect: 433, 29, 551, 38 Page: Sequence: 11 Annotations: Annotation: Subtype: Link Rect: 263, 99, 292, 110 ActionDest: 665 Annotation: Subtype: Link Rect: 43, 88, 67, 99 ActionDest: 665 Annotation: Subtype: Link Rect: 74, 88, 94, 99 ActionDest: 665 Annotation: Subtype: Link Rect: 305, 123, 354, 133 ActionDest: 735 Annotation: Subtype: Link Rect: 357, 123, 377, 133 ActionDest: 735 Annotation: Subtype: Link Rect: 43, 29, 119, 38 Annotation: Subtype: Link Rect: 122, 29, 182, 38 Annotation: Subtype: Link Rect: 433, 29, 551, 38 Page: Sequence: 12 Annotations: Annotation: Subtype: Link Rect: 67, 649, 114, 660 ActionDest: 735 Annotation: Subtype: Link Rect: 116, 649, 136, 660 ActionDest: 735 Annotation: Subtype: Link Rect: 184, 637, 219, 648 ActionDest: 362 Annotation: Subtype: Link Rect: 47, 580, 81, 591 ActionDest: 362 Annotation: Subtype: Link Rect: 157, 557, 248, 568 ActionDest: 665 Annotation: Subtype: Link Rect: 230, 500, 292, 511 ActionDest: 665 Annotation: Subtype: Link Rect: 43, 488, 72, 500 ActionDest: 665 Annotation: Subtype: Link Rect: 276, 419, 292, 431 ActionDest: 776 Annotation: Subtype: Link Rect: 43, 408, 101, 419 ActionDest: 776 Annotation: Subtype: Link Rect: 106, 408, 127, 419 ActionDest: 776 Annotation: Subtype: Link Rect: 230, 374, 292, 385 ActionDest: 665 Annotation: Subtype: Link Rect: 43, 362, 72, 373 ActionDest: 665 Annotation: Subtype: Link Rect: 47, 317, 107, 328 ActionDest: 776 Annotation: Subtype: Link Rect: 111, 317, 131, 328 ActionDest: 776 Annotation: Subtype: Link Rect: 136, 317, 219, 328 ActionDest: 776 Annotation: Subtype: Link Rect: 223, 317, 243, 328 ActionDest: 776 Annotation: Subtype: Link Rect: 47, 270, 78, 282 ActionDest: 446 Annotation: Subtype: Link Rect: 116, 225, 166, 236 ActionDest: 326 Annotation: Subtype: Link Rect: 217, 213, 252, 225 ActionDest: 326 Annotation: Subtype: Link Rect: 154, 190, 189, 202 ActionDest: 427 Annotation: Subtype: Link Rect: 231, 133, 268, 144 ActionDest: 427 Annotation: Subtype: Link Rect: 258, 76, 289, 87 ActionDest: 446 Annotation: Subtype: Link Rect: 397, 626, 454, 637 ActionDest: 735 Annotation: Subtype: Link Rect: 456, 626, 476, 637 ActionDest: 735 Annotation: Subtype: Link Rect: 478, 626, 506, 637 ActionDest: 665 Annotation: Subtype: Link Rect: 508, 626, 529, 637 ActionDest: 665 Annotation: Subtype: Link Rect: 305, 569, 362, 580 ActionDest: 665 Annotation: Subtype: Link Rect: 366, 569, 386, 580 ActionDest: 665 Annotation: Subtype: Link Rect: 390, 569, 444, 580 ActionDest: 665 Annotation: Subtype: Link Rect: 448, 569, 468, 580 ActionDest: 665 Annotation: Subtype: Link Rect: 472, 569, 524, 580 ActionDest: 735 Annotation: Subtype: Link Rect: 528, 569, 549, 580 ActionDest: 735 Annotation: Subtype: Link Rect: 302, 557, 350, 568 ActionDest: 665 Annotation: Subtype: Link Rect: 353, 557, 373, 568 ActionDest: 665 Annotation: Subtype: Link Rect: 450, 477, 520, 488 ActionDest: 776 Annotation: Subtype: Link Rect: 525, 477, 545, 488 ActionDest: 776 Annotation: Subtype: Link Rect: 397, 466, 447, 477 ActionDest: 735 Annotation: Subtype: Link Rect: 450, 466, 470, 477 ActionDest: 735 Annotation: Subtype: Link Rect: 448, 278, 551, 289 Annotation: Subtype: Link Rect: 302, 267, 321, 278 Annotation: Subtype: Link Rect: 379, 255, 489, 267 Annotation: Subtype: Link Rect: 43, 29, 119, 38 Annotation: Subtype: Link Rect: 122, 29, 182, 38 Annotation: Subtype: Link Rect: 433, 29, 551, 38 Page: Sequence: 13 Annotations: Annotation: Subtype: Link Rect: 384, 694, 505, 706 Annotation: Subtype: Link Rect: 354, 628, 551, 639 Annotation: Subtype: Link Rect: 302, 616, 460, 628 Annotation: Subtype: Link Rect: 252, 546, 293, 555 Annotation: Subtype: Link Rect: 53, 537, 94, 546 Annotation: Subtype: Link Rect: 239, 498, 293, 508 Annotation: Subtype: Link Rect: 53, 489, 81, 498 Annotation: Subtype: Link Rect: 207, 461, 293, 470 Annotation: Subtype: Link Rect: 199, 442, 293, 451 Annotation: Subtype: Link Rect: 214, 423, 293, 432 Annotation: Subtype: Link Rect: 53, 415, 95, 422 Annotation: Subtype: Link Rect: 233, 394, 293, 404 Annotation: Subtype: Link Rect: 53, 387, 91, 394 Annotation: Subtype: Link Rect: 251, 347, 293, 356 Annotation: Subtype: Link Rect: 53, 338, 102, 347 Annotation: Subtype: Link Rect: 203, 310, 293, 319 Annotation: Subtype: Link Rect: 238, 281, 293, 290 Annotation: Subtype: Link Rect: 53, 273, 88, 280 Annotation: Subtype: Link Rect: 155, 243, 261, 252 Annotation: Subtype: Link Rect: 115, 205, 233, 214 Annotation: Subtype: Link Rect: 77, 177, 174, 186 Annotation: Subtype: Link Rect: 251, 158, 293, 167 Annotation: Subtype: Link Rect: 53, 148, 151, 158 Annotation: Subtype: Link Rect: 158, 110, 244, 120 Annotation: Subtype: Link Rect: 214, 82, 293, 91 Annotation: Subtype: Link Rect: 53, 74, 95, 81 Annotation: Subtype: Link Rect: 375, 537, 464, 546 Annotation: Subtype: Link Rect: 341, 510, 432, 517 Annotation: Subtype: Link Rect: 509, 489, 551, 498 Annotation: Subtype: Link Rect: 312, 480, 384, 489 Annotation: Subtype: Link Rect: 412, 451, 506, 460 Annotation: Subtype: Link Rect: 428, 433, 522, 442 Annotation: Subtype: Link Rect: 508, 414, 551, 423 Annotation: Subtype: Link Rect: 312, 406, 351, 412 Annotation: Subtype: Link Rect: 379, 375, 455, 385 Annotation: Subtype: Link Rect: 428, 357, 518, 366 Annotation: Subtype: Link Rect: 499, 328, 551, 337 Annotation: Subtype: Link Rect: 312, 320, 336, 328 Annotation: Subtype: Link Rect: 461, 290, 551, 300 Annotation: Subtype: Link Rect: 312, 282, 339, 289 Annotation: Subtype: Link Rect: 359, 253, 431, 262 Annotation: Subtype: Link Rect: 510, 224, 551, 233 Annotation: Subtype: Link Rect: 312, 215, 391, 224 Annotation: Subtype: Link Rect: 312, 187, 414, 195 Annotation: Subtype: Link Rect: 394, 167, 496, 177 Annotation: Subtype: Link Rect: 451, 129, 551, 139 Annotation: Subtype: Link Rect: 312, 122, 328, 129 Annotation: Subtype: Link Rect: 508, 101, 551, 110 Annotation: Subtype: Link Rect: 312, 93, 358, 101 Annotation: Subtype: Link Rect: 43, 29, 119, 38 Annotation: Subtype: Link Rect: 122, 29, 182, 38 Annotation: Subtype: Link Rect: 433, 29, 551, 38 Page: Sequence: 14 Annotations: Annotation: Subtype: Link Rect: 279, 707, 293, 716 Annotation: Subtype: Link Rect: 53, 697, 127, 706 Annotation: Subtype: Link Rect: 227, 670, 293, 678 Annotation: Subtype: Link Rect: 53, 661, 81, 668 Annotation: Subtype: Link Rect: 177, 621, 259, 631 Annotation: Subtype: Link Rect: 105, 602, 193, 612 Annotation: Subtype: Link Rect: 131, 574, 234, 583 Annotation: Subtype: Link Rect: 252, 545, 293, 555 Annotation: Subtype: Link Rect: 53, 538, 106, 545 Annotation: Subtype: Link Rect: 279, 517, 293, 526 Annotation: Subtype: Link Rect: 53, 509, 123, 517 Annotation: Subtype: Link Rect: 222, 481, 293, 489 Annotation: Subtype: Link Rect: 53, 472, 75, 478 Annotation: Subtype: Link Rect: 53, 442, 166, 451 Annotation: Subtype: Link Rect: 129, 414, 215, 422 Annotation: Subtype: Link Rect: 53, 385, 167, 394 Annotation: Subtype: Link Rect: 268, 328, 293, 337 Annotation: Subtype: Link Rect: 53, 320, 131, 327 Annotation: Subtype: Link Rect: 228, 299, 293, 309 Annotation: Subtype: Link Rect: 53, 292, 70, 299 Annotation: Subtype: Link Rect: 129, 263, 212, 271 Annotation: Subtype: Link Rect: 109, 235, 203, 243 Annotation: Subtype: Link Rect: 279, 205, 293, 214 Annotation: Subtype: Link Rect: 53, 195, 147, 205 Annotation: Subtype: Link Rect: 252, 167, 293, 176 Annotation: Subtype: Link Rect: 53, 158, 92, 166 Annotation: Subtype: Link Rect: 173, 138, 279, 148 Annotation: Subtype: Link Rect: 127, 102, 219, 110 Annotation: Subtype: Link Rect: 82, 72, 219, 82 Annotation: Subtype: Link Rect: 312, 687, 384, 697 Annotation: Subtype: Link Rect: 312, 659, 399, 668 Annotation: Subtype: Link Rect: 312, 622, 436, 631 Annotation: Subtype: Link Rect: 440, 593, 551, 602 Annotation: Subtype: Link Rect: 312, 585, 328, 592 Annotation: Subtype: Link Rect: 456, 545, 551, 555 Annotation: Subtype: Link Rect: 312, 538, 328, 545 Annotation: Subtype: Link Rect: 470, 517, 551, 526 Annotation: Subtype: Link Rect: 312, 509, 339, 517 Annotation: Subtype: Link Rect: 445, 470, 551, 479 Annotation: Subtype: Link Rect: 312, 462, 328, 469 Annotation: Subtype: Link Rect: 537, 432, 551, 441 Annotation: Subtype: Link Rect: 312, 424, 389, 431 Annotation: Subtype: Link Rect: 537, 394, 551, 403 Annotation: Subtype: Link Rect: 312, 386, 385, 394 Annotation: Subtype: Link Rect: 470, 356, 551, 366 Annotation: Subtype: Link Rect: 312, 347, 334, 355 Annotation: Subtype: Link Rect: 508, 328, 551, 337 Annotation: Subtype: Link Rect: 312, 318, 381, 328 Annotation: Subtype: Link Rect: 505, 299, 551, 309 Annotation: Subtype: Link Rect: 312, 290, 366, 299 Annotation: Subtype: Link Rect: 488, 271, 551, 280 Annotation: Subtype: Link Rect: 312, 263, 330, 270 Annotation: Subtype: Link Rect: 369, 243, 457, 252 Annotation: Subtype: Link Rect: 450, 214, 551, 224 Annotation: Subtype: Link Rect: 312, 207, 330, 213 Annotation: Subtype: Link Rect: 495, 176, 551, 186 Annotation: Subtype: Link Rect: 312, 167, 334, 176 Annotation: Subtype: Link Rect: 475, 129, 551, 138 Annotation: Subtype: Link Rect: 312, 121, 328, 128 Annotation: Subtype: Link Rect: 477, 83, 551, 91 Annotation: Subtype: Link Rect: 312, 74, 328, 81 Annotation: Subtype: Link Rect: 43, 29, 119, 38 Annotation: Subtype: Link Rect: 122, 29, 182, 38 Annotation: Subtype: Link Rect: 433, 29, 551, 38 Page: Sequence: 15 Annotations: Annotation: Subtype: Link Rect: 82, 688, 176, 697 Annotation: Subtype: Link Rect: 68, 659, 185, 668 Annotation: Subtype: Link Rect: 234, 640, 293, 649 Annotation: Subtype: Link Rect: 53, 632, 88, 639 Annotation: Subtype: Link Rect: 193, 602, 293, 612 Annotation: Subtype: Link Rect: 53, 595, 70, 601 Annotation: Subtype: Link Rect: 210, 555, 293, 564 Annotation: Subtype: Link Rect: 509, 706, 551, 716 Annotation: Subtype: Link Rect: 312, 698, 360, 706 Annotation: Subtype: Link Rect: 479, 659, 551, 668 Annotation: Subtype: Link Rect: 312, 651, 328, 658 Annotation: Subtype: Link Rect: 431, 583, 457, 593 Annotation: Subtype: Link Rect: 458, 583, 490, 593 Annotation: Subtype: Link Rect: 491, 583, 527, 593 Annotation: Subtype: Link Rect: 528, 583, 551, 593 Annotation: Subtype: Link Rect: 302, 574, 329, 583 Annotation: Subtype: Link Rect: 43, 29, 119, 38 Annotation: Subtype: Link Rect: 122, 29, 182, 38 Annotation: Subtype: Link Rect: 433, 29, 551, 38 Checksum: 1ac39436 Type: CRC32 Checksum: 0209e3c8c67d155190c95245e9232aaf Type: MD5 Checksum: ce2da7c08cbb42484f1f56f5f678dcd327b97076 Type: SHA-1