85b167080c13e697d4877e7d177f34e9 222858.pdf f57f613672359f004eb300b2a94be8e64e7e02a7 222858.pdf bd86bf6754bfdb1558200ad4ae3a0c38cc38e33f3dccf02ab3e03d00b7f78486 222858.pdf Producer: iText® 7.1.1 ©2000-2018 iText Group NV (AGPL-version) CreationDate: Wed Oct 23 11:03:37 2019 CEST ModDate: Wed Oct 23 11:03:37 2019 CEST Tagged: no UserProperties: no Suspects: no Form: none JavaScript: no Pages: 17 Encrypted: no Page size: 595.276 x 841.89 pts (A4) Page rot: 0 File size: 2526913 bytes Optimized: no PDF version: 1.7 name type encoding emb sub uni object ID ------------------------------------ ----------------- ---------------- --- --- --- --------- YSPQJI+VnURWPalladioL-Bold Type 1 Custom yes yes no 10 0 USXBDB+Pxsy Type 1 Builtin yes yes no 15 0 XEFGQJ+VnURWPalladioL Type 1 Custom yes yes no 19 0 GGPKAT+URWPalladioL-Ital Type 1 Custom yes yes no 23 0 IAZHSL+URWPalladioL-Bold Type 1 Custom yes yes no 28 0 AFXIMB+URWPalladioL-Roma Type 1 Custom yes yes no 32 0 IELMKZ+Rpxr Type 1 Builtin yes yes no 36 0 QTLELQ+Pxbsy Type 1 Builtin yes yes no 40 0 LCJEVJ+TimesNewRomanPS-BoldItalicMT Type 1C WinAnsi yes yes no 49 0 MCBCCI+SourceSansRoman-Regular Type 1C Custom yes yes no 71 0 MCBCCM+SourceSansRoman.613wght Type 1C Custom yes yes no 75 0 MCBCCO+SourceSansRoman-Bold Type 1C Custom yes yes no 79 0 BCDEEE+PalatinoLinotype-Roman TrueType WinAnsi yes yes no 94 0 BCDFEE+PalatinoLinotype-Italic TrueType WinAnsi yes yes no 98 0 BCDGEE+PalatinoLinotype-Bold TrueType WinAnsi yes yes no 102 0 BCDEEE+PalatinoLinotype-Roman TrueType WinAnsi yes yes no 115 0 BCDFEE+PalatinoLinotype-Italic TrueType WinAnsi yes yes no 119 0 BCDGEE+PalatinoLinotype-Bold TrueType WinAnsi yes yes no 123 0 LEVXPH+EURM10 Type 1 Builtin yes yes no 138 0 BCDEEE+PalatinoLinotype-Roman TrueType WinAnsi yes yes no 146 0 BCDFEE+PalatinoLinotype-Italic TrueType WinAnsi yes yes no 150 0 BCDGEE+PalatinoLinotype-Bold TrueType WinAnsi yes yes no 154 0 BCDIEE+PalatinoLinotype-Roman CID TrueType Identity-H yes yes yes 158 0 BCDEEE+PalatinoLinotype-Roman TrueType WinAnsi yes yes no 177 0 BCDFEE+PalatinoLinotype-Italic TrueType WinAnsi yes yes no 181 0 BCDGEE+PalatinoLinotype-Bold TrueType WinAnsi yes yes no 185 0 BCDIEE+PalatinoLinotype-Roman CID TrueType Identity-H yes yes yes 189 0 BCDEEE+PalatinoLinotype-Roman TrueType WinAnsi yes yes no 205 0 BCDFEE+PalatinoLinotype-Italic TrueType WinAnsi yes yes no 209 0 BCDGEE+PalatinoLinotype-Bold TrueType WinAnsi yes yes no 213 0 BCDIEE+PalatinoLinotype-Roman CID TrueType Identity-H yes yes yes 217 0 BCDEEE+PalatinoLinotype-Roman TrueType WinAnsi yes yes no 233 0 BCDFEE+PalatinoLinotype-Italic TrueType WinAnsi yes yes no 237 0 BCDGEE+PalatinoLinotype-Bold TrueType WinAnsi yes yes no 241 0 BCDIEE+PalatinoLinotype-Roman CID TrueType Identity-H yes yes yes 245 0 YICMPF+Rpcxr Type 1 Builtin yes yes no 263 0 Jhove (Rel. 1.22.1, 2019-04-17) Date: 2021-04-08 02:50:43 CEST RepresentationInformation: 222858.pdf ReportingModule: PDF-hul, Rel. 1.12.1 (2019-04-17) LastModified: 2021-04-07 19:09:17 CEST Size: 2526913 Format: PDF Version: 1.7 Status: Well-Formed and valid SignatureMatches: PDF-hul MIMEtype: application/pdf PDFMetadata: Objects: 449 FreeObjects: 1 IncrementalUpdates: 0 DocumentCatalog: PageLayout: SinglePage PageMode: UseNone Outlines: Item: Title: Introduction Destination: edu.harvard.hul.ois.jhove.module.pdf.PdfSimpleObject@13c27452 Item: Title: Results Destination: edu.harvard.hul.ois.jhove.module.pdf.PdfSimpleObject@262b2c86 Children: Item: Title: Cdk5 and p35 Are Broadly Expressed in CRC Cell Lines Destination: edu.harvard.hul.ois.jhove.module.pdf.PdfSimpleObject@371a67ec Item: Title: Cdk5 siRNA-Mediated Gene Silencing Impaired CRC Cells Migration and Invasion Destination: edu.harvard.hul.ois.jhove.module.pdf.PdfSimpleObject@5ed828d Item: Title: Cdk5 and p35 Are Overexpressed in CRC Tumor Samples Destination: edu.harvard.hul.ois.jhove.module.pdf.PdfSimpleObject@50d0686 Item: Title: High Cdk5 Levels Correlate with Poorer Prognosis in CRC Patients Destination: edu.harvard.hul.ois.jhove.module.pdf.PdfSimpleObject@7a3d45bd Item: Title: Cdk5 Is Associated with Consensus Molecular Subtype 1 Destination: edu.harvard.hul.ois.jhove.module.pdf.PdfSimpleObject@1e7c7811 Item: Title: Discussion Destination: edu.harvard.hul.ois.jhove.module.pdf.PdfSimpleObject@77ec78b9 Item: Title: Material and Methods Destination: edu.harvard.hul.ois.jhove.module.pdf.PdfSimpleObject@1a3869f4 Children: Item: Title: Human CRC Cell Lines Destination: edu.harvard.hul.ois.jhove.module.pdf.PdfSimpleObject@a38d7a3 Item: Title: Gene Silencing Destination: edu.harvard.hul.ois.jhove.module.pdf.PdfSimpleObject@77f99a05 Item: Title: Cell Proliferation Destination: edu.harvard.hul.ois.jhove.module.pdf.PdfSimpleObject@63440df3 Item: Title: Colony Formation Assay Destination: edu.harvard.hul.ois.jhove.module.pdf.PdfSimpleObject@3aeaafa6 Item: Title: Migration and Invasion Destination: edu.harvard.hul.ois.jhove.module.pdf.PdfSimpleObject@76a3e297 Item: Title: Immunoprecipitation Destination: edu.harvard.hul.ois.jhove.module.pdf.PdfSimpleObject@4d3167f4 Item: Title: Western Blotting Destination: edu.harvard.hul.ois.jhove.module.pdf.PdfSimpleObject@ed9d034 Item: Title: Patients’ Samples Destination: edu.harvard.hul.ois.jhove.module.pdf.PdfSimpleObject@6121c9d6 Item: Title: Tissue Microarray and Immunohistochemistry (IHC) Staining Destination: edu.harvard.hul.ois.jhove.module.pdf.PdfSimpleObject@87f383f Item: Title: qPCR Destination: edu.harvard.hul.ois.jhove.module.pdf.PdfSimpleObject@4eb7f003 Item: Title: In Silico Data Destination: edu.harvard.hul.ois.jhove.module.pdf.PdfSimpleObject@eafc191 Item: Title: Statistical Analysis Destination: edu.harvard.hul.ois.jhove.module.pdf.PdfSimpleObject@612fc6eb Item: Title: Conclusions Destination: edu.harvard.hul.ois.jhove.module.pdf.PdfSimpleObject@1060b431 Item: Title: References Destination: edu.harvard.hul.ois.jhove.module.pdf.PdfSimpleObject@612679d6 Info: Producer: iText® 7.1.1 ©2000-2018 iText Group NV (AGPL-version) CreationDate: Wed Oct 23 11:03:37 CEST 2019 ModDate: Wed Oct 23 11:03:37 CEST 2019 ID: 0xeabcb3685f5bde085a1770203c5bd6e5, 0xeabcb3685f5bde085a1770203c5bd6e5 Filters: FilterPipeline: FlateDecode Fonts: Type1: Font: BaseFont: AFXIMB+URWPalladioL-Roma FontSubset: true FirstChar: 2 LastChar: 231 FontDescriptor: FontName: AFXIMB+URWPalladioL-Roma Flags: Symbolic FontBBox: -166, -283, 1021, 943 FontFile: true EncodingDictionary: Differences: true Font: BaseFont: XEFGQJ+VnURWPalladioL FontSubset: true FirstChar: 160 LastChar: 226 FontDescriptor: FontName: XEFGQJ+VnURWPalladioL Flags: Symbolic FontBBox: -166, -283, 1021, 943 FontFile: true EncodingDictionary: Differences: true Font: BaseFont: IELMKZ+Rpxr FontSubset: true FirstChar: 11 LastChar: 61 FontDescriptor: FontName: IELMKZ+Rpxr Flags: Symbolic FontBBox: -40, -283, 904, 728 FontFile: true Font: BaseFont: GGPKAT+URWPalladioL-Ital FontSubset: true FirstChar: 39 LastChar: 121 FontDescriptor: FontName: GGPKAT+URWPalladioL-Ital Flags: Symbolic FontBBox: -170, -305, 1010, 941 FontFile: true EncodingDictionary: Differences: true Font: BaseFont: YICMPF+Rpcxr FontSubset: true FirstChar: 151 LastChar: 174 FontDescriptor: FontName: YICMPF+Rpcxr Flags: Symbolic FontBBox: -212, -286, 1344, 973 FontFile: true Font: BaseFont: QTLELQ+Pxbsy FontSubset: true FirstChar: 121 LastChar: 121 FontDescriptor: FontName: QTLELQ+Pxbsy Flags: Symbolic FontBBox: 5, -978, 1382, 913 FontFile: true Font: BaseFont: YSPQJI+VnURWPalladioL-Bold FontSubset: true FirstChar: 178 LastChar: 189 FontDescriptor: FontName: YSPQJI+VnURWPalladioL-Bold Flags: Symbolic FontBBox: -152, -301, 1000, 935 FontFile: true EncodingDictionary: Differences: true Font: BaseFont: LEVXPH+EURM10 FontSubset: true FirstChar: 11 LastChar: 22 FontDescriptor: FontName: LEVXPH+EURM10 Flags: Symbolic FontBBox: -32, -243, 1060, 720 FontFile: true Font: BaseFont: IAZHSL+URWPalladioL-Bold FontSubset: true FirstChar: 3 LastChar: 231 FontDescriptor: FontName: IAZHSL+URWPalladioL-Bold Flags: Symbolic FontBBox: -152, -301, 1000, 935 FontFile: true EncodingDictionary: Differences: true Font: BaseFont: USXBDB+Pxsy FontSubset: true FirstChar: 0 LastChar: 121 FontDescriptor: FontName: USXBDB+Pxsy Flags: Symbolic FontBBox: -21, -994, 1292, 912 FontFile: true Pages: Page: Sequence: 1 Annotations: Annotation: Subtype: Link Rect: 75, 757, 193, 793 Annotation: Subtype: Link Rect: 474, 757, 519, 793 Annotation: Subtype: Link Rect: 414, 621, 425, 634 Annotation: Subtype: Link Rect: 279, 607, 290, 621 Annotation: Subtype: Link Rect: 437, 607, 448, 621 Annotation: Subtype: Link Rect: 168, 594, 179, 607 Annotation: Subtype: Link Rect: 314, 580, 325, 594 Annotation: Subtype: Link Rect: 168, 38, 256, 50 Annotation: Subtype: Link Rect: 404, 38, 519, 50 Annotation: Subtype: Link Rect: 466, 236, 518, 255 Page: Sequence: 2 Annotations: Annotation: Subtype: Link Rect: 346, 525, 353, 534 ActionDest: 270 Annotation: Subtype: Link Rect: 145, 471, 152, 480 ActionDest: 270 Annotation: Subtype: Link Rect: 292, 390, 299, 399 ActionDest: 270 Annotation: Subtype: Link Rect: 300, 390, 307, 399 ActionDest: 270 Annotation: Subtype: Link Rect: 261, 363, 268, 372 ActionDest: 270 Annotation: Subtype: Link Rect: 377, 349, 384, 359 ActionDest: 270 Annotation: Subtype: Link Rect: 212, 336, 219, 345 ActionDest: 270 Annotation: Subtype: Link Rect: 250, 336, 257, 345 ActionDest: 270 Annotation: Subtype: Link Rect: 304, 336, 310, 345 ActionDest: 270 Annotation: Subtype: Link Rect: 366, 336, 378, 345 ActionDest: 270 Annotation: Subtype: Link Rect: 300, 255, 307, 264 ActionDest: 270 Annotation: Subtype: Link Rect: 451, 241, 463, 250 ActionDest: 270 Annotation: Subtype: Link Rect: 121, 214, 128, 223 ActionDest: 270 Annotation: Subtype: Link Rect: 128, 214, 140, 223 ActionDest: 270 Annotation: Subtype: Link Rect: 288, 174, 300, 183 ActionDest: 270 Annotation: Subtype: Link Rect: 459, 160, 470, 169 ActionDest: 273 Annotation: Subtype: Link Rect: 318, 147, 330, 156 ActionDest: 273 Annotation: Subtype: Link Rect: 485, 120, 497, 129 ActionDest: 273 Page: Sequence: 3 Annotations: Annotation: Subtype: Link Rect: 338, 684, 345, 695 ActionDest: 86 Annotation: Subtype: Link Rect: 311, 659, 318, 668 ActionDest: 270 Annotation: Subtype: Link Rect: 182, 646, 189, 655 ActionDest: 270 Annotation: Subtype: Link Rect: 190, 646, 202, 655 ActionDest: 273 Annotation: Subtype: Link Rect: 301, 632, 313, 641 ActionDest: 273 Annotation: Subtype: Link Rect: 451, 575, 458, 587 ActionDest: 86 Annotation: Subtype: Link Rect: 445, 565, 457, 574 ActionDest: 273 Annotation: Subtype: Link Rect: 167, 136, 174, 148 ActionDest: 107 Annotation: Subtype: Link Rect: 492, 95, 499, 107 ActionDest: 107 Annotation: Subtype: Link Rect: 200, 71, 212, 80 ActionDest: 273 Annotation: Subtype: Link Rect: 439, 71, 451, 80 ActionDest: 273 Page: Sequence: 4 Annotations: Annotation: Subtype: Link Rect: 324, 686, 331, 698 ActionDest: 107 Page: Sequence: 5 Annotations: Annotation: Subtype: Link Rect: 214, 632, 221, 644 ActionDest: 131 Annotation: Subtype: Link Rect: 144, 605, 152, 617 ActionDest: 134 Annotation: Subtype: Link Rect: 501, 591, 508, 603 ActionDest: 134 Annotation: Subtype: Link Rect: 304, 551, 311, 563 ActionDest: 134 Annotation: Subtype: Link Rect: 107, 537, 114, 549 ActionDest: 134 Annotation: Subtype: Link Rect: 143, 497, 150, 510 ActionDest: 134 Annotation: Subtype: Link Rect: 285, 483, 292, 495 ActionDest: 134 Annotation: Subtype: Link Rect: 387, 470, 394, 483 ActionDest: 134 Page: Sequence: 6 Annotations: Annotation: Subtype: Link Rect: 592, 299, 645, 309 Annotation: Subtype: Link Rect: 558, 290, 638, 299 Page: Sequence: 7 Page: Sequence: 8 Annotations: Annotation: Subtype: Link Rect: 394, 580, 401, 592 ActionDest: 131 Annotation: Subtype: Link Rect: 427, 526, 434, 538 ActionDest: 134 Annotation: Subtype: Link Rect: 339, 499, 346, 511 ActionDest: 131 Annotation: Subtype: Link Rect: 212, 445, 219, 457 ActionDest: 169 Annotation: Subtype: Link Rect: 335, 377, 342, 389 ActionDest: 131 Annotation: Subtype: Link Rect: 442, 377, 449, 389 ActionDest: 169 Annotation: Subtype: Link Rect: 106, 337, 113, 348 ActionDest: 169 Annotation: Subtype: Link Rect: 321, 323, 328, 335 ActionDest: 169 Page: Sequence: 9 Annotations: Annotation: Subtype: Link Rect: 187, 78, 194, 87 ActionDest: 270 Page: Sequence: 10 Annotations: Annotation: Subtype: Link Rect: 428, 713, 435, 725 ActionDest: 197 Annotation: Subtype: Link Rect: 408, 686, 415, 698 ActionDest: 197 Annotation: Subtype: Link Rect: 439, 364, 450, 373 ActionDest: 273 Annotation: Subtype: Link Rect: 404, 337, 416, 346 ActionDest: 273 Annotation: Subtype: Link Rect: 232, 280, 239, 292 ActionDest: 225 Annotation: Subtype: Link Rect: 330, 229, 342, 238 ActionDest: 273 Annotation: Subtype: Link Rect: 384, 213, 391, 225 ActionDest: 225 Page: Sequence: 11 Annotations: Annotation: Subtype: Link Rect: 331, 224, 343, 233 ActionDest: 273 Annotation: Subtype: Link Rect: 333, 103, 345, 112 ActionDest: 273 Page: Sequence: 12 Annotations: Annotation: Subtype: Link Rect: 157, 742, 169, 752 ActionDest: 273 Annotation: Subtype: Link Rect: 127, 715, 139, 725 ActionDest: 273 Annotation: Subtype: Link Rect: 111, 675, 118, 684 ActionDest: 270 Annotation: Subtype: Link Rect: 118, 675, 125, 684 ActionDest: 270 Annotation: Subtype: Link Rect: 126, 675, 138, 684 ActionDest: 270 Annotation: Subtype: Link Rect: 140, 675, 152, 684 ActionDest: 273 Annotation: Subtype: Link Rect: 310, 621, 322, 630 ActionDest: 273 Annotation: Subtype: Link Rect: 264, 580, 271, 590 ActionDest: 270 Annotation: Subtype: Link Rect: 273, 553, 285, 562 ActionDest: 273 Annotation: Subtype: Link Rect: 343, 526, 355, 535 ActionDest: 273 Annotation: Subtype: Link Rect: 356, 526, 368, 535 ActionDest: 273 Annotation: Subtype: Link Rect: 464, 418, 476, 427 ActionDest: 270 Annotation: Subtype: Link Rect: 192, 256, 199, 265 ActionDest: 270 Annotation: Subtype: Link Rect: 199, 256, 211, 265 ActionDest: 273 Annotation: Subtype: Link Rect: 333, 134, 345, 144 ActionDest: 273 Annotation: Subtype: Link Rect: 107, 94, 119, 103 ActionDest: 273 Page: Sequence: 13 Annotations: Annotation: Subtype: Link Rect: 227, 688, 239, 698 ActionDest: 273 Page: Sequence: 14 Annotations: Annotation: Subtype: Link Rect: 154, 324, 161, 336 ActionDest: 86 Annotation: Subtype: Link Rect: 201, 324, 208, 336 ActionDest: 134 Annotation: Subtype: Link Rect: 159, 268, 166, 280 ActionDest: 131 Annotation: Subtype: Link Rect: 503, 174, 515, 183 ActionDest: 273 Annotation: Subtype: Link Rect: 407, 160, 419, 170 ActionDest: 273 Annotation: Subtype: Link Rect: 419, 160, 431, 170 ActionDest: 273 Page: Sequence: 15 Annotations: Annotation: Subtype: Link Rect: 456, 723, 468, 732 ActionDest: 273 Annotation: Subtype: Link Rect: 469, 723, 481, 732 ActionDest: 273 Annotation: Subtype: Link Rect: 240, 559, 252, 568 ActionDest: 273 Annotation: Subtype: Link Rect: 165, 505, 177, 514 ActionDest: 273 Annotation: Subtype: Link Rect: 481, 505, 493, 514 ActionDest: 273 Annotation: Subtype: Link Rect: 331, 111, 518, 122 Page: Sequence: 16 Annotations: Annotation: Subtype: Link Rect: 462, 740, 469, 751 ActionDest: 86 Annotation: Subtype: Link Rect: 505, 740, 511, 751 ActionDest: 134 Annotation: Subtype: Link Rect: 145, 507, 183, 517 Annotation: Subtype: Link Rect: 189, 507, 225, 517 Annotation: Subtype: Link Rect: 409, 480, 446, 491 Annotation: Subtype: Link Rect: 452, 480, 488, 491 Annotation: Subtype: Link Rect: 290, 442, 328, 452 Annotation: Subtype: Link Rect: 334, 442, 370, 452 Annotation: Subtype: Link Rect: 443, 403, 480, 414 Annotation: Subtype: Link Rect: 358, 364, 395, 375 Annotation: Subtype: Link Rect: 479, 338, 516, 349 Annotation: Subtype: Link Rect: 447, 299, 485, 310 Annotation: Subtype: Link Rect: 440, 274, 478, 285 Annotation: Subtype: Link Rect: 145, 236, 183, 246 Annotation: Subtype: Link Rect: 154, 197, 192, 207 Annotation: Subtype: Link Rect: 377, 157, 414, 168 Annotation: Subtype: Link Rect: 421, 157, 457, 168 Annotation: Subtype: Link Rect: 478, 119, 516, 130 Annotation: Subtype: Link Rect: 100, 107, 136, 117 Page: Sequence: 17 Annotations: Annotation: Subtype: Link Rect: 177, 715, 214, 725 Annotation: Subtype: Link Rect: 220, 715, 256, 725 Annotation: Subtype: Link Rect: 478, 675, 516, 686 Annotation: Subtype: Link Rect: 100, 663, 136, 673 Annotation: Subtype: Link Rect: 390, 637, 428, 648 Annotation: Subtype: Link Rect: 381, 624, 419, 635 Annotation: Subtype: Link Rect: 446, 598, 484, 609 Annotation: Subtype: Link Rect: 340, 559, 378, 570 Annotation: Subtype: Link Rect: 480, 521, 516, 531 Annotation: Subtype: Link Rect: 181, 483, 219, 493 Annotation: Subtype: Link Rect: 326, 443, 364, 454 Annotation: Subtype: Link Rect: 370, 443, 406, 454 Annotation: Subtype: Link Rect: 219, 404, 257, 415 Annotation: Subtype: Link Rect: 263, 404, 299, 415 Annotation: Subtype: Link Rect: 352, 366, 390, 376 Annotation: Subtype: Link Rect: 396, 366, 432, 376 Annotation: Subtype: Link Rect: 320, 327, 358, 338 Annotation: Subtype: Link Rect: 145, 289, 182, 299 Annotation: Subtype: Link Rect: 250, 249, 287, 260 Annotation: Subtype: Link Rect: 100, 199, 137, 209 Annotation: Subtype: Link Rect: 452, 159, 490, 170 Annotation: Subtype: Link Rect: 341, 121, 379, 131 Annotation: Subtype: Link Rect: 76, 79, 166, 110 Annotation: Subtype: Link Rect: 234, 73, 407, 84 Checksum: eb94c9d8 Type: CRC32 Checksum: 85b167080c13e697d4877e7d177f34e9 Type: MD5 Checksum: f57f613672359f004eb300b2a94be8e64e7e02a7 Type: SHA-1