cd3e41ec48fbe1c5d1446ecaaa8dc4a9  pdf_222881.pdf
c48a954cc3d1a1daf735de9570f16f2521a70d2a  pdf_222881.pdf
4c64290757420f99ecb91e887418872a19fe3790e42ca218b5780e1bf3981abd  pdf_222881.pdf

Title:          Metabolic adaptation in the human gut microbiota during pregnancy and the first year of life
Subject:        EBioMedicine, 39 (2018) 497-509. doi:10.1016/j.ebiom.2018.10.071
Keywords:       Metatranscriptomics;  Microbiota;  Gut;  Metabolism;  Infant;  Pregnancy
Author:         María José Gosalbes
Creator:        Elsevier
Producer:       Acrobat Distiller 10.0.0 (Windows)
CreationDate:   Thu Jan 17 10:29:29 2019 CET
ModDate:        Tue Feb 16 11:12:51 2021 CET
Tagged:         no
UserProperties: no
Suspects:       no
Form:           none
JavaScript:     no
Pages:          13
Encrypted:      no
Page size:      595.276 x 793.701 pts
Page rot:       0
File size:      3738662 bytes
Optimized:      yes
PDF version:    1.7


name                                 type              encoding         emb sub uni object ID
------------------------------------ ----------------- ---------------- --- --- --- ---------
FHLCFL+AdvTT5235d5a9                 Type 1C           WinAnsi          yes yes no     663  0
FHLCFM+AdvTT5235d5a9+fb              Type 1C           Custom           yes yes yes    666  0
FHLCGN+AdvTT5235d5a9+20              Type 1C           Custom           yes yes yes    669  0
FHLCGO+AdvTT94c8263f.I               Type 1C           WinAnsi          yes yes no     671  0
FHLCGP+AdvTT94c8263f.I+fb            Type 1C           Custom           yes yes yes    674  0
FHLCHA+AdvTT94c8263f.I+01            Type 1C           Custom           yes yes yes    677  0
FHLCIB+AdvTT0f485e03                 Type 1C           WinAnsi          yes yes no     679  0
FHLCIC+AdvTT28000ce1.B               Type 1C           WinAnsi          yes yes no     681  0
FHLDAP+AdvTTc8c83e50                 Type 1C           WinAnsi          yes yes no     683  0
FHLDEP+AdvTT454a7a89                 Type 1C           WinAnsi          yes yes no     368  0
FHLDFA+AdvTT5235d5a9+22              Type 1C           Custom           yes yes no     363  0
FHLDGA+AdvTT5235d5a9+21              Type 1C           WinAnsi          yes yes no     370  0
FHLDGB+AdvTT47a11158.B               Type 1C           WinAnsi          yes yes no     362  0
FHLDGC+AdvTT6b11a639.I               Type 1C           WinAnsi          yes yes no     366  0
FHLDHD+AdvTT94c8263f.I+20            Type 1C           WinAnsi          yes yes no     359  0
FHMMDM+AdvTT5235d5a9+03              Type 1C           Custom           yes yes yes    379  0


Jhove (Rel. 1.22.1, 2019-04-17)
 Date: 2021-04-29 02:36:28 CEST
 RepresentationInformation: pdf_222881.pdf
  ReportingModule: PDF-hul, Rel. 1.12.1 (2019-04-17)
  LastModified: 2021-02-16 11:13:09 CET
  Size: 3738662
  Format: PDF
  Version: 1.7
  Status: Well-Formed and valid
  SignatureMatches:
   PDF-hul
  MIMEtype: application/pdf
  Profile: Linearized PDF
  PDFMetadata: 
   Objects: 0
   FreeObjects: 1
   IncrementalUpdates: 0
   DocumentCatalog: 
    PageLayout: SinglePage
    PageMode: UseOutlines
    Outlines: 
     Item: 
      Title: Metabolic adaptation in the human gut microbiota during pregnancy and the first year of life
      Destination: edu.harvard.hul.ois.jhove.module.pdf.PdfSimpleObject@757942a1
      Children: 
       Item: 
        Title: 1. Introduction
        Destination: edu.harvard.hul.ois.jhove.module.pdf.PdfSimpleObject@4a87761d
       Item: 
        Title: 2. Materials and methods
        Destination: edu.harvard.hul.ois.jhove.module.pdf.PdfSimpleObject@66d1af89
        Children: 
         Item: 
          Title: Outline placeholder
          Destination: edu.harvard.hul.ois.jhove.module.pdf.PdfSimpleObject@8646db9
          Children: 
           Item: 
            Title: 2.1.1. Human subjects
            Destination: edu.harvard.hul.ois.jhove.module.pdf.PdfSimpleObject@37374a5e
           Item: 
            Title: 2.1.2. Sample collection
            Destination: edu.harvard.hul.ois.jhove.module.pdf.PdfSimpleObject@4671e53b
           Item: 
            Title: 2.1.3. RNA purification and sequencing
            Destination: edu.harvard.hul.ois.jhove.module.pdf.PdfSimpleObject@2db7a79b
           Item: 
            Title: 2.1.4. Sequence processing, assembly and annotation
            Destination: edu.harvard.hul.ois.jhove.module.pdf.PdfSimpleObject@6950e31
       Item: 
        Title: Evidence before this study
        Destination: edu.harvard.hul.ois.jhove.module.pdf.PdfSimpleObject@b7dd107
       Item: 
        Title: Added value of this study
        Destination: edu.harvard.hul.ois.jhove.module.pdf.PdfSimpleObject@42eca56e
       Item: 
        Title: Implications of all the available evidence
        Destination: edu.harvard.hul.ois.jhove.module.pdf.PdfSimpleObject@52f759d7
        Children: 
         Item: 
          Title: Outline placeholder
          Destination: edu.harvard.hul.ois.jhove.module.pdf.PdfSimpleObject@7cbd213e
          Children: 
           Item: 
            Title: 2.1.5. Analyses of metagenome and metatranscriptome variation
            Destination: edu.harvard.hul.ois.jhove.module.pdf.PdfSimpleObject@192d3247
           Item: 
            Title: 2.1.6. Biomarker detection
            Destination: edu.harvard.hul.ois.jhove.module.pdf.PdfSimpleObject@3ecd23d9
           Item: 
            Title: 2.1.7. Gene expression analysis
            Destination: edu.harvard.hul.ois.jhove.module.pdf.PdfSimpleObject@569cfc36
           Item: 
            Title: 2.1.8. Data availability
            Destination: edu.harvard.hul.ois.jhove.module.pdf.PdfSimpleObject@43bd930a
       Item: 
        Title: 3. Results
        Destination: edu.harvard.hul.ois.jhove.module.pdf.PdfSimpleObject@33723e30
        Children: 
         Item: 
          Title: Outline placeholder
          Destination: edu.harvard.hul.ois.jhove.module.pdf.PdfSimpleObject@64f6106c
          Children: 
           Item: 
            Title: 3.1.1. Functional composition of the metatranscriptome in infants and mothers
            Destination: edu.harvard.hul.ois.jhove.module.pdf.PdfSimpleObject@553a3d88
           Item: 
            Title: 3.1.2. Defined directionality of change in the metatranscriptome along infant development
            Destination: edu.harvard.hul.ois.jhove.module.pdf.PdfSimpleObject@7a30d1e6
           Item: 
            Title: 3.1.3. Temporal dynamics of specific functions in the metatranscriptome
            Destination: edu.harvard.hul.ois.jhove.module.pdf.PdfSimpleObject@5891e32e
           Item: 
            Title: 3.1.4. Over- and underexpressed functions in the gut metatranscriptome
            Destination: edu.harvard.hul.ois.jhove.module.pdf.PdfSimpleObject@cb0ed20
           Item: 
            Title: 3.1.5. Stage-specific gene expression during the first year of life
            Destination: edu.harvard.hul.ois.jhove.module.pdf.PdfSimpleObject@8e24743
           Item: 
            Title: 3.1.6. Expression differences remaining at one year of life in comparison to mothers
            Destination: edu.harvard.hul.ois.jhove.module.pdf.PdfSimpleObject@74a10858
           Item: 
            Title: 3.1.7. Altered expression of specific bacterial functions during late pregnancy
            Destination: edu.harvard.hul.ois.jhove.module.pdf.PdfSimpleObject@23fe1d71
       Item: 
        Title: 4. Discussion
        Destination: edu.harvard.hul.ois.jhove.module.pdf.PdfSimpleObject@28ac3dc3
        Children: 
         Item: 
          Title: Outline placeholder
          Destination: edu.harvard.hul.ois.jhove.module.pdf.PdfSimpleObject@32eebfca
          Children: 
           Item: 
            Title: 4.1.1. Adaptation of microbiota gene expression to late pregnancy conditions
            Destination: edu.harvard.hul.ois.jhove.module.pdf.PdfSimpleObject@4e718207
           Item: 
            Title: 4.1.2. Adaptation of microbiota gene expression during the first year of life
            Destination: edu.harvard.hul.ois.jhove.module.pdf.PdfSimpleObject@1d371b2d
       Item: 
        Title: Acknowledgments
        Destination: edu.harvard.hul.ois.jhove.module.pdf.PdfSimpleObject@543c6f6d
       Item: 
        Title: Author contributions
        Destination: edu.harvard.hul.ois.jhove.module.pdf.PdfSimpleObject@13eb8acf
       Item: 
        Title: Declaration of interests
        Destination: edu.harvard.hul.ois.jhove.module.pdf.PdfSimpleObject@51c8530f
       Item: 
        Title: References
        Destination: edu.harvard.hul.ois.jhove.module.pdf.PdfSimpleObject@7403c468
   Filters: 
    FilterPipeline: FlateDecode
    FilterPipeline: DCTDecode
   Images: 
    Image: 
     NisoImageMetadata: 
      FormatName: image/jpg
      CompressionScheme: JPEG
      ImageWidth: 689
      ImageHeight: 178
      ColorSpace: RGB
      BitsPerSample: 8
      BitsPerSampleUnit: integer
    Image: 
     NisoImageMetadata: 
      FormatName: image/jpg
      CompressionScheme: JPEG
      ImageWidth: 248
      ImageHeight: 272
      ColorSpace: CMYK
      BitsPerSample: 8
      BitsPerSampleUnit: integer
    Image: 
     NisoImageMetadata: 
      FormatName: image/jpg
      CompressionScheme: JPEG
      ImageWidth: 2144
      ImageHeight: 2167
      ColorSpace: RGB
      BitsPerSample: 8
      BitsPerSampleUnit: integer
    Image: 
     NisoImageMetadata: 
      FormatName: image/jpg
      CompressionScheme: JPEG
      ImageWidth: 2132
      ImageHeight: 1686
      ColorSpace: RGB
      BitsPerSample: 8
      BitsPerSampleUnit: integer
    Image: 
     NisoImageMetadata: 
      FormatName: image/jpg
      CompressionScheme: JPEG
      ImageWidth: 1424
      ImageHeight: 1260
      ColorSpace: black is zero
      BitsPerSample: 8
      BitsPerSampleUnit: integer
    Image: 
     NisoImageMetadata: 
      FormatName: image/jpg
      CompressionScheme: JPEG
      ImageWidth: 2144
      ImageHeight: 1713
      ColorSpace: RGB
      BitsPerSample: 8
      BitsPerSampleUnit: integer
    Image: 
     NisoImageMetadata: 
      FormatName: image/jpg
      CompressionScheme: JPEG
      ImageWidth: 2144
      ImageHeight: 2035
      ColorSpace: RGB
      BitsPerSample: 8
      BitsPerSampleUnit: integer
   Fonts: 
    Type1: 
     Font: 
      BaseFont: FHLCGP+AdvTT94c8263f.I+fb
      FontSubset: true
      FirstChar: 1
      LastChar: 1
      FontDescriptor: 
       FontName: FHLCGP+AdvTT94c8263f.I+fb
       Flags: Symbolic
       FontBBox: -114, -291, 1406, 968
       FontFile3: true
      EncodingDictionary: 
       Differences: true
      ToUnicode: true
     Font: 
      BaseFont: FHLCHA+AdvTT94c8263f.I+01
      FontSubset: true
      FirstChar: 1
      LastChar: 1
      FontDescriptor: 
       FontName: FHLCHA+AdvTT94c8263f.I+01
       Flags: Symbolic
       FontBBox: -135, -302, 1364, 1145
       FontFile3: true
      EncodingDictionary: 
       Differences: true
      ToUnicode: true
     Font: 
      BaseFont: FHLCIB+AdvTT0f485e03
      FontSubset: true
      FirstChar: 97
      LastChar: 116
      FontDescriptor: 
       FontName: FHLCIB+AdvTT0f485e03
       Flags: Serif, Nonsymbolic
       FontBBox: -72, -250, 1041, 979
       FontFile3: true
      Encoding: WinAnsiEncoding
     Font: 
      BaseFont: FHLDHD+AdvTT94c8263f.I+20
      FontSubset: true
      FirstChar: 150
      LastChar: 150
      FontDescriptor: 
       FontName: FHLDHD+AdvTT94c8263f.I+20
       Flags: Nonsymbolic
       FontBBox: -875, -270, 1333, 979
       FontFile3: true
      Encoding: WinAnsiEncoding
     Font: 
      BaseFont: FHLCIC+AdvTT28000ce1.B
      FontSubset: true
      FirstChar: 46
      LastChar: 119
      FontDescriptor: 
       FontName: FHLCIC+AdvTT28000ce1.B
       Flags: Nonsymbolic
       FontBBox: -93, -250, 1041, 989
       FontFile3: true
      Encoding: WinAnsiEncoding
     Font: 
      BaseFont: FHLDGB+AdvTT47a11158.B
      FontSubset: true
      FirstChar: 82
      LastChar: 120
      FontDescriptor: 
       FontName: FHLDGB+AdvTT47a11158.B
       Flags: Nonsymbolic
       FontBBox: -41, -250, 968, 895
       FontFile3: true
      Encoding: WinAnsiEncoding
     Font: 
      BaseFont: FHLDAP+AdvTTc8c83e50
      FontSubset: true
      FirstChar: 44
      LastChar: 122
      FontDescriptor: 
       FontName: FHLDAP+AdvTTc8c83e50
       Flags: Nonsymbolic
       FontBBox: -10, -250, 968, 895
       FontFile3: true
      Encoding: WinAnsiEncoding
     Font: 
      BaseFont: FHLDFA+AdvTT5235d5a9+22
      FontSubset: true
      FirstChar: 21
      LastChar: 21
      FontDescriptor: 
       FontName: FHLDFA+AdvTT5235d5a9+22
       Flags: Nonsymbolic
       FontBBox: -135, -208, 1125, 1041
       FontFile3: true
      EncodingDictionary: 
       BaseEncoding: WinAnsiEncoding
       Differences: true
     Font: 
      BaseFont: FHLDGC+AdvTT6b11a639.I
      FontSubset: true
      FirstChar: 65
      LastChar: 121
      FontDescriptor: 
       FontName: FHLDGC+AdvTT6b11a639.I
       Flags: Nonsymbolic
       FontBBox: -114, -250, 1083, 885
       FontFile3: true
      Encoding: WinAnsiEncoding
     Font: 
      BaseFont: FHLDEP+AdvTT454a7a89
      FontSubset: true
      FirstChar: 78
      LastChar: 98
      FontDescriptor: 
       FontName: FHLDEP+AdvTT454a7a89
       Flags: Nonsymbolic
       FontBBox: -52, -208, 968, 802
       FontFile3: true
      Encoding: WinAnsiEncoding
     Font: 
      BaseFont: FHLDGA+AdvTT5235d5a9+21
      FontSubset: true
      FirstChar: 153
      LastChar: 153
      FontDescriptor: 
       FontName: FHLDGA+AdvTT5235d5a9+21
       Flags: Nonsymbolic
       FontBBox: -197, -260, 1541, 937
       FontFile3: true
      Encoding: WinAnsiEncoding
     Font: 
      BaseFont: FHLCFL+AdvTT5235d5a9
      FontSubset: true
      FirstChar: 35
      LastChar: 250
      FontDescriptor: 
       FontName: FHLCFL+AdvTT5235d5a9
       Flags: Serif, Nonsymbolic
       FontBBox: -72, -250, 1041, 979
       FontFile3: true
      Encoding: WinAnsiEncoding
     Font: 
      BaseFont: FHLCFM+AdvTT5235d5a9+fb
      FontSubset: true
      FirstChar: 1
      LastChar: 3
      FontDescriptor: 
       FontName: FHLCFM+AdvTT5235d5a9+fb
       Flags: Symbolic
       FontBBox: 9, -291, 1333, 968
       FontFile3: true
      EncodingDictionary: 
       Differences: true
      ToUnicode: true
     Font: 
      BaseFont: FHMMDM+AdvTT5235d5a9+03
      FontSubset: true
      FirstChar: 1
      LastChar: 3
      FontDescriptor: 
       FontName: FHMMDM+AdvTT5235d5a9+03
       Flags: Symbolic
       FontBBox: -843, -291, 1062, 968
       FontFile3: true
      EncodingDictionary: 
       Differences: true
      ToUnicode: true
     Font: 
      BaseFont: FHLCGN+AdvTT5235d5a9+20
      FontSubset: true
      FirstChar: 1
      LastChar: 144
      FontDescriptor: 
       FontName: FHLCGN+AdvTT5235d5a9+20
       Flags: Symbolic
       FontBBox: -875, -270, 1312, 979
       FontFile3: true
      EncodingDictionary: 
       Differences: true
      ToUnicode: true
     Font: 
      BaseFont: FHLCGO+AdvTT94c8263f.I
      FontSubset: true
      FirstChar: 39
      LastChar: 250
      FontDescriptor: 
       FontName: FHLCGO+AdvTT94c8263f.I
       Flags: Serif, Nonsymbolic
       FontBBox: -135, -229, 1052, 968
       FontFile3: true
      Encoding: WinAnsiEncoding
   XMP: <x:xmpmeta xmlns:x="adobe:ns:meta/" x:xmptk="Adobe XMP Core 5.6-c017 91.164464, 2020/06/15-10:20:05        ">
   <rdf:RDF xmlns:rdf="http://www.w3.org/1999/02/22-rdf-syntax-ns#">
      <rdf:Description rdf:about=""
            xmlns:dc="http://purl.org/dc/elements/1.1/"
            xmlns:prism="http://prismstandard.org/namespaces/basic/3.0/"
            xmlns:crossmark="http://crossref.org/crossmark/1.0/"
            xmlns:jav="http://www.niso.org/schemas/jav/1.0/"
            xmlns:pdfx="http://ns.adobe.com/pdfx/1.3/"
            xmlns:xmp="http://ns.adobe.com/xap/1.0/"
            xmlns:xmpRights="http://ns.adobe.com/xap/1.0/rights/"
            xmlns:pdf="http://ns.adobe.com/pdf/1.3/"
            xmlns:xmpMM="http://ns.adobe.com/xap/1.0/mm/">
         <dc:format>application/pdf</dc:format>
         <dc:identifier>doi:10.1016/j.ebiom.2018.10.071</dc:identifier>
         <dc:title>
            <rdf:Alt>
               <rdf:li xml:lang="x-default">Metabolic adaptation in the human gut microbiota during pregnancy and the first year of life</rdf:li>
            </rdf:Alt>
         </dc:title>
         <dc:creator>
            <rdf:Seq>
               <rdf:li>María José Gosalbes</rdf:li>
               <rdf:li>Joan Compte</rdf:li>
               <rdf:li>Silvia Moriano-Gutierrez</rdf:li>
               <rdf:li>Yvonne Vallès</rdf:li>
               <rdf:li>Nuria Jiménez-Hernández</rdf:li>
               <rdf:li>Xavier Pons</rdf:li>
               <rdf:li>Alejandro Artacho</rdf:li>
               <rdf:li>M. Pilar Francino</rdf:li>
            </rdf:Seq>
         </dc:creator>
         <dc:subject>
            <rdf:Bag>
               <rdf:li>Metatranscriptomics</rdf:li>
               <rdf:li>Microbiota</rdf:li>
               <rdf:li>Gut</rdf:li>
               <rdf:li>Metabolism</rdf:li>
               <rdf:li>Infant</rdf:li>
               <rdf:li>Pregnancy</rdf:li>
            </rdf:Bag>
         </dc:subject>
         <dc:description>
            <rdf:Alt>
               <rdf:li xml:lang="x-default">EBioMedicine, 39 (2018) 497-509. doi:10.1016/j.ebiom.2018.10.071</rdf:li>
            </rdf:Alt>
         </dc:description>
         <dc:publisher>
            <rdf:Bag>
               <rdf:li>The Authors</rdf:li>
            </rdf:Bag>
         </dc:publisher>
         <prism:aggregationType>journal</prism:aggregationType>
         <prism:publicationName>EBioMedicine</prism:publicationName>
         <prism:copyright>(c) 2018 The Authors All rights reserved</prism:copyright>
         <prism:issn>2352-3964</prism:issn>
         <prism:volume>39</prism:volume>
         <prism:issueIdentifier>C</prism:issueIdentifier>
         <prism:coverDisplayDate>January 2019</prism:coverDisplayDate>
         <prism:coverDate>2019-01</prism:coverDate>
         <prism:pageRange>497-509</prism:pageRange>
         <prism:startingPage>497</prism:startingPage>
         <prism:endingPage>509</prism:endingPage>
         <prism:doi>10.1016/j.ebiom.2018.10.071</prism:doi>
         <prism:url>https://doi.org/10.1016/j.ebiom.2018.10.071</prism:url>
         <crossmark:MajorVersionDate>2010-04-23</crossmark:MajorVersionDate>
         <crossmark:CrossmarkDomainExclusive>true</crossmark:CrossmarkDomainExclusive>
         <crossmark:DOI>10.1016/j.ebiom.2018.10.071</crossmark:DOI>
         <crossmark:CrossMarkDomains>
            <rdf:Seq>
               <rdf:li>elsevier.com</rdf:li>
               <rdf:li>sciencedirect.com</rdf:li>
            </rdf:Seq>
         </crossmark:CrossMarkDomains>
         <jav:journal_article_version>VoR</jav:journal_article_version>
         <pdfx:doi>10.1016/j.ebiom.2018.10.071</pdfx:doi>
         <pdfx:robots>noindex</pdfx:robots>
         <pdfx:CrossmarkMajorVersionDate>2010-04-23</pdfx:CrossmarkMajorVersionDate>
         <pdfx:CrossmarkDomainExclusive>true</pdfx:CrossmarkDomainExclusive>
         <pdfx:CrossMarkDomains>
            <rdf:Seq>
               <rdf:li>elsevier.com</rdf:li>
               <rdf:li>sciencedirect.com</rdf:li>
            </rdf:Seq>
         </pdfx:CrossMarkDomains>
         <xmp:CreatorTool>Elsevier</xmp:CreatorTool>
         <xmp:CreateDate>2019-01-17T17:29:29+08:00</xmp:CreateDate>
         <xmp:ModifyDate>2021-02-16T11:12:51+01:00</xmp:ModifyDate>
         <xmp:MetadataDate>2021-02-16T11:12:51+01:00</xmp:MetadataDate>
         <xmpRights:Marked>True</xmpRights:Marked>
         <pdf:Keywords>Metatranscriptomics;  Microbiota;  Gut;  Metabolism;  Infant;  Pregnancy</pdf:Keywords>
         <pdf:Producer>Acrobat Distiller 10.0.0 (Windows)</pdf:Producer>
         <xmpMM:DocumentID>uuid:8d2f2942-7f1c-41cb-bceb-5549cef6650d</xmpMM:DocumentID>
         <xmpMM:InstanceID>uuid:cde03855-0a32-4e6f-93ff-5fc18b6b7484</xmpMM:InstanceID>
      </rdf:Description>
   </rdf:RDF>
</x:xmpmeta>
   Pages: 
    Page: 
     Label: 497
     Sequence: 1
     Annotations: 
      Annotation: 
       Subtype: Link
       Rect: 505, 602, 533, 630
      Annotation: 
       Subtype: Link
       Rect: 138, 577, 142, 588
       Destination: 548
      Annotation: 
       Subtype: Link
       Rect: 144, 577, 148, 588
       Destination: 548
      Annotation: 
       Subtype: Link
       Rect: 216, 577, 220, 588
       Destination: 548
      Annotation: 
       Subtype: Link
       Rect: 222, 577, 225, 588
       Destination: 548
      Annotation: 
       Subtype: Link
       Rect: 349, 577, 353, 588
       Destination: 548
      Annotation: 
       Subtype: Link
       Rect: 355, 577, 360, 588
       Destination: 548
      Annotation: 
       Subtype: Link
       Rect: 434, 577, 438, 588
       Destination: 548
      Annotation: 
       Subtype: Link
       Rect: 439, 577, 443, 588
       Destination: 548
      Annotation: 
       Subtype: Link
       Rect: 167, 564, 171, 575
       Destination: 548
      Annotation: 
       Subtype: Link
       Rect: 173, 564, 177, 575
       Destination: 548
      Annotation: 
       Subtype: Link
       Rect: 241, 564, 244, 575
       Destination: 548
      Annotation: 
       Subtype: Link
       Rect: 338, 564, 342, 575
       Destination: 548
      Annotation: 
       Subtype: Link
       Rect: 429, 564, 433, 575
       Destination: 548
      Annotation: 
       Subtype: Link
       Rect: 435, 564, 439, 575
       Destination: 548
      Annotation: 
       Subtype: Link
       Rect: 441, 560, 446, 572
       Destination: 548
      Annotation: 
       Subtype: Link
       Rect: 398, 263, 556, 270
      Annotation: 
       Subtype: Link
       Rect: 45, 136, 49, 144
       Destination: 36
      Annotation: 
       Subtype: Link
       Rect: 51, 136, 60, 144
       Destination: 36
      Annotation: 
       Subtype: Link
       Rect: 62, 136, 71, 144
       Destination: 36
      Annotation: 
       Subtype: Link
       Rect: 72, 136, 81, 144
       Destination: 36
      Annotation: 
       Subtype: Link
       Rect: 83, 136, 92, 144
       Destination: 40
      Annotation: 
       Subtype: Link
       Rect: 94, 136, 103, 144
       Destination: 40
      Annotation: 
       Subtype: Link
       Rect: 313, 115, 322, 123
       Destination: 36
      Annotation: 
       Subtype: Link
       Rect: 324, 115, 333, 123
       Destination: 40
      Annotation: 
       Subtype: Link
       Rect: 254, 749, 349, 755
      Annotation: 
       Subtype: Link
       Rect: 98, 84, 153, 90
      Annotation: 
       Subtype: Link
       Rect: 42, 56, 167, 63
      Annotation: 
       Subtype: Link
       Rect: 386, 48, 530, 54
      Annotation: 
       Subtype: Link
       Rect: 269, 721, 318, 729
      Annotation: 
       Subtype: Link
       Rect: 236, 666, 345, 674
    Page: 
     Label: 498
     Sequence: 2
     Annotations: 
      Annotation: 
       Subtype: Link
       Rect: 39, 308, 48, 316
       Destination: 36
      Annotation: 
       Subtype: Link
       Rect: 50, 308, 59, 316
       Destination: 36
      Annotation: 
       Subtype: Link
       Rect: 61, 308, 70, 316
       Destination: 36
      Annotation: 
       Subtype: Link
       Rect: 71, 308, 80, 316
       Destination: 36
      Annotation: 
       Subtype: Link
       Rect: 36, 277, 45, 285
       Destination: 40
      Annotation: 
       Subtype: Link
       Rect: 106, 100, 115, 108
       Destination: 40
      Annotation: 
       Subtype: Link
       Rect: 121, 58, 172, 66
       Destination: 4
      Annotation: 
       Subtype: Link
       Rect: 486, 539, 512, 547
       Destination: 4
      Annotation: 
       Subtype: Link
       Rect: 497, 529, 501, 537
       Destination: 36
      Annotation: 
       Subtype: Link
       Rect: 391, 372, 400, 380
       Destination: 40
      Annotation: 
       Subtype: Link
       Rect: 469, 163, 478, 171
       Destination: 36
      Annotation: 
       Subtype: Link
       Rect: 358, 152, 367, 160
       Destination: 40
      Annotation: 
       Subtype: Link
       Rect: 531, 131, 535, 139
       Destination: 36
      Annotation: 
       Subtype: Link
       Rect: 304, 100, 309, 108
       Destination: 36
      Annotation: 
       Subtype: Link
       Rect: 372, 100, 381, 108
       Destination: 36
      Annotation: 
       Subtype: Link
       Rect: 540, 100, 549, 108
       Destination: 36
      Annotation: 
       Subtype: Link
       Rect: 382, 68, 391, 76
       Destination: 36
    Page: 
     Label: 499
     Sequence: 3
     Annotations: 
      Annotation: 
       Subtype: Link
       Rect: 70, 590, 79, 598
       Destination: 36
      Annotation: 
       Subtype: Link
       Rect: 45, 579, 54, 587
       Destination: 36
      Annotation: 
       Subtype: Link
       Rect: 68, 569, 77, 577
       Destination: 40
      Annotation: 
       Subtype: Link
       Rect: 239, 445, 248, 453
       Destination: 40
      Annotation: 
       Subtype: Link
       Rect: 313, 273, 322, 281
       Destination: 40
      Annotation: 
       Subtype: Link
       Rect: 223, 377, 226, 383
       Destination: 4
      Annotation: 
       Subtype: Link
       Rect: 202, 329, 205, 336
       Destination: 4
      Annotation: 
       Subtype: Link
       Rect: 75, 287, 77, 293
       Destination: 4
    Page: 
     Label: 500
     Sequence: 4
     Annotations: 
      Annotation: 
       Subtype: Link
       Rect: 313, 675, 332, 683
       Destination: 7
    Page: 
     Label: 501
     Sequence: 5
     Annotations: 
      Annotation: 
       Subtype: Link
       Rect: 152, 728, 161, 736
       Destination: 40
      Annotation: 
       Subtype: Link
       Rect: 180, 497, 189, 505
       Destination: 40
      Annotation: 
       Subtype: Link
       Rect: 189, 403, 199, 411
       Destination: 40
      Annotation: 
       Subtype: Link
       Rect: 187, 351, 206, 359
       Destination: 14
      Annotation: 
       Subtype: Link
       Rect: 88, 173, 107, 181
       Destination: 14
      Annotation: 
       Subtype: Link
       Rect: 96, 131, 116, 139
       Destination: 14
      Annotation: 
       Subtype: Link
       Rect: 64, 121, 73, 129
       Destination: 40
      Annotation: 
       Subtype: Link
       Rect: 458, 403, 477, 411
       Destination: 18
      Annotation: 
       Subtype: Link
       Rect: 331, 288, 340, 296
       Destination: 40
      Annotation: 
       Subtype: Link
       Rect: 356, 79, 376, 87
       Destination: 22
    Page: 
     Label: 502
     Sequence: 6
     Annotations: 
      Annotation: 
       Subtype: Link
       Rect: 164, 142, 182, 150
       Destination: 22
      Annotation: 
       Subtype: Link
       Rect: 396, 194, 414, 202
       Destination: 22
      Annotation: 
       Subtype: Link
       Rect: 502, 131, 511, 139
       Destination: 40
    Page: 
     Label: 503
     Sequence: 7
     Annotations: 
      Annotation: 
       Subtype: Link
       Rect: 54, 311, 75, 319
       Destination: 26
      Annotation: 
       Subtype: Link
       Rect: 87, 48, 107, 56
       Destination: 26
      Annotation: 
       Subtype: Link
       Rect: 313, 332, 339, 340
       Destination: 30
    Page: 
     Label: 504
     Sequence: 8
     Annotations: 
      Annotation: 
       Subtype: Link
       Rect: 259, 184, 279, 192
       Destination: 26
      Annotation: 
       Subtype: Link
       Rect: 378, 173, 404, 181
       Destination: 30
      Annotation: 
       Subtype: Link
       Rect: 331, 79, 361, 87
       Destination: 30
    Page: 
     Label: 505
     Sequence: 9
     Annotations: 
      Annotation: 
       Subtype: Link
       Rect: 46, 184, 64, 192
       Destination: 26
      Annotation: 
       Subtype: Link
       Rect: 222, 142, 249, 150
       Destination: 30
      Annotation: 
       Subtype: Link
       Rect: 376, 79, 385, 87
       Destination: 40
      Annotation: 
       Subtype: Link
       Rect: 314, 48, 333, 56
       Destination: 26
    Page: 
     Label: 506
     Sequence: 10
     Annotations: 
      Annotation: 
       Subtype: Link
       Rect: 106, 262, 132, 270
       Destination: 30
      Annotation: 
       Subtype: Link
       Rect: 234, 262, 259, 270
       Destination: 30
      Annotation: 
       Subtype: Link
       Rect: 67, 68, 86, 76
       Destination: 26
      Annotation: 
       Subtype: Link
       Rect: 508, 293, 533, 301
       Destination: 30
    Page: 
     Label: 507
     Sequence: 11
     Annotations: 
      Annotation: 
       Subtype: Link
       Rect: 184, 445, 189, 453
       Destination: 36
      Annotation: 
       Subtype: Link
       Rect: 191, 445, 195, 453
       Destination: 36
      Annotation: 
       Subtype: Link
       Rect: 45, 361, 54, 369
       Destination: 36
      Annotation: 
       Subtype: Link
       Rect: 96, 246, 105, 254
       Destination: 36
      Annotation: 
       Subtype: Link
       Rect: 77, 225, 86, 233
       Destination: 36
      Annotation: 
       Subtype: Link
       Rect: 114, 163, 123, 171
       Destination: 36
      Annotation: 
       Subtype: Link
       Rect: 136, 48, 145, 56
       Destination: 36
      Annotation: 
       Subtype: Link
       Rect: 465, 644, 469, 652
       Destination: 36
      Annotation: 
       Subtype: Link
       Rect: 471, 644, 476, 652
       Destination: 36
      Annotation: 
       Subtype: Link
       Rect: 477, 644, 486, 652
       Destination: 36
      Annotation: 
       Subtype: Link
       Rect: 372, 518, 381, 526
       Destination: 40
      Annotation: 
       Subtype: Link
       Rect: 364, 330, 373, 338
       Destination: 36
      Annotation: 
       Subtype: Link
       Rect: 375, 330, 384, 338
       Destination: 40
      Annotation: 
       Subtype: Link
       Rect: 386, 330, 395, 338
       Destination: 40
      Annotation: 
       Subtype: Link
       Rect: 435, 257, 444, 265
       Destination: 36
      Annotation: 
       Subtype: Link
       Rect: 449, 225, 458, 233
       Destination: 40
      Annotation: 
       Subtype: Link
       Rect: 423, 184, 432, 192
       Destination: 36
      Annotation: 
       Subtype: Link
       Rect: 547, 48, 556, 56
       Destination: 40
    Page: 
     Label: 508
     Sequence: 12
     Annotations: 
      Annotation: 
       Subtype: Link
       Rect: 122, 665, 132, 673
       Destination: 40
      Annotation: 
       Subtype: Link
       Rect: 262, 612, 271, 620
       Destination: 40
      Annotation: 
       Subtype: Link
       Rect: 190, 477, 199, 484
       Destination: 40
      Annotation: 
       Subtype: Link
       Rect: 237, 320, 247, 328
       Destination: 40
      Annotation: 
       Subtype: Link
       Rect: 245, 246, 284, 254
      Annotation: 
       Subtype: Link
       Rect: 33, 236, 151, 244
      Annotation: 
       Subtype: Link
       Rect: 316, 670, 552, 677
      Annotation: 
       Subtype: Link
       Rect: 316, 662, 411, 669
      Annotation: 
       Subtype: Link
       Rect: 316, 646, 448, 653
      Annotation: 
       Subtype: Link
       Rect: 316, 638, 552, 645
      Annotation: 
       Subtype: Link
       Rect: 316, 630, 552, 637
      Annotation: 
       Subtype: Link
       Rect: 316, 622, 408, 629
      Annotation: 
       Subtype: Link
       Rect: 316, 614, 552, 621
      Annotation: 
       Subtype: Link
       Rect: 316, 606, 552, 613
      Annotation: 
       Subtype: Link
       Rect: 316, 598, 410, 605
      Annotation: 
       Subtype: Link
       Rect: 316, 590, 552, 597
      Annotation: 
       Subtype: Link
       Rect: 316, 582, 552, 589
      Annotation: 
       Subtype: Link
       Rect: 316, 575, 476, 581
      Annotation: 
       Subtype: Link
       Rect: 316, 567, 552, 573
      Annotation: 
       Subtype: Link
       Rect: 316, 559, 552, 565
      Annotation: 
       Subtype: Link
       Rect: 316, 551, 508, 557
      Annotation: 
       Subtype: Link
       Rect: 316, 543, 552, 549
      Annotation: 
       Subtype: Link
       Rect: 316, 535, 552, 541
      Annotation: 
       Subtype: Link
       Rect: 316, 527, 348, 533
      Annotation: 
       Subtype: Link
       Rect: 316, 519, 552, 525
      Annotation: 
       Subtype: Link
       Rect: 316, 511, 552, 517
      Annotation: 
       Subtype: Link
       Rect: 316, 503, 390, 509
      Annotation: 
       Subtype: Link
       Rect: 316, 495, 552, 501
      Annotation: 
       Subtype: Link
       Rect: 316, 487, 525, 493
      Annotation: 
       Subtype: Link
       Rect: 316, 479, 552, 485
      Annotation: 
       Subtype: Link
       Rect: 316, 471, 477, 477
      Annotation: 
       Subtype: Link
       Rect: 316, 463, 552, 469
      Annotation: 
       Subtype: Link
       Rect: 316, 455, 552, 461
      Annotation: 
       Subtype: Link
       Rect: 316, 447, 521, 453
      Annotation: 
       Subtype: Link
       Rect: 316, 439, 552, 445
      Annotation: 
       Subtype: Link
       Rect: 316, 431, 552, 437
      Annotation: 
       Subtype: Link
       Rect: 316, 423, 355, 429
      Annotation: 
       Subtype: Link
       Rect: 316, 415, 552, 421
      Annotation: 
       Subtype: Link
       Rect: 316, 407, 552, 414
      Annotation: 
       Subtype: Link
       Rect: 316, 399, 406, 406
      Annotation: 
       Subtype: Link
       Rect: 316, 391, 552, 398
      Annotation: 
       Subtype: Link
       Rect: 316, 383, 552, 390
      Annotation: 
       Subtype: Link
       Rect: 316, 375, 552, 382
      Annotation: 
       Subtype: Link
       Rect: 316, 367, 552, 374
      Annotation: 
       Subtype: Link
       Rect: 316, 359, 470, 366
      Annotation: 
       Subtype: Link
       Rect: 316, 351, 552, 358
      Annotation: 
       Subtype: Link
       Rect: 316, 343, 552, 350
      Annotation: 
       Subtype: Link
       Rect: 316, 335, 464, 342
      Annotation: 
       Subtype: Link
       Rect: 316, 327, 552, 334
      Annotation: 
       Subtype: Link
       Rect: 316, 319, 552, 326
      Annotation: 
       Subtype: Link
       Rect: 316, 311, 371, 318
      Annotation: 
       Subtype: Link
       Rect: 316, 304, 552, 310
      Annotation: 
       Subtype: Link
       Rect: 316, 296, 552, 302
      Annotation: 
       Subtype: Link
       Rect: 316, 288, 368, 294
      Annotation: 
       Subtype: Link
       Rect: 316, 280, 552, 286
      Annotation: 
       Subtype: Link
       Rect: 316, 272, 552, 278
      Annotation: 
       Subtype: Link
       Rect: 316, 264, 502, 270
      Annotation: 
       Subtype: Link
       Rect: 316, 256, 552, 262
      Annotation: 
       Subtype: Link
       Rect: 316, 248, 427, 254
      Annotation: 
       Subtype: Link
       Rect: 316, 240, 552, 246
      Annotation: 
       Subtype: Link
       Rect: 316, 232, 552, 238
      Annotation: 
       Subtype: Link
       Rect: 316, 224, 552, 230
      Annotation: 
       Subtype: Link
       Rect: 316, 216, 552, 222
      Annotation: 
       Subtype: Link
       Rect: 316, 208, 448, 214
      Annotation: 
       Subtype: Link
       Rect: 316, 200, 552, 206
      Annotation: 
       Subtype: Link
       Rect: 316, 192, 403, 198
      Annotation: 
       Subtype: Link
       Rect: 316, 184, 552, 190
      Annotation: 
       Subtype: Link
       Rect: 316, 176, 539, 182
      Annotation: 
       Subtype: Link
       Rect: 316, 168, 552, 174
      Annotation: 
       Subtype: Link
       Rect: 316, 160, 456, 166
      Annotation: 
       Subtype: Link
       Rect: 316, 152, 552, 158
      Annotation: 
       Subtype: Link
       Rect: 316, 144, 552, 151
      Annotation: 
       Subtype: Link
       Rect: 316, 136, 355, 143
      Annotation: 
       Subtype: Link
       Rect: 316, 128, 552, 135
      Annotation: 
       Subtype: Link
       Rect: 316, 120, 490, 127
      Annotation: 
       Subtype: Link
       Rect: 316, 112, 552, 119
      Annotation: 
       Subtype: Link
       Rect: 316, 104, 552, 111
      Annotation: 
       Subtype: Link
       Rect: 316, 96, 355, 103
      Annotation: 
       Subtype: Link
       Rect: 316, 88, 552, 95
      Annotation: 
       Subtype: Link
       Rect: 316, 80, 552, 87
      Annotation: 
       Subtype: Link
       Rect: 316, 72, 499, 79
      Annotation: 
       Subtype: Link
       Rect: 316, 64, 552, 71
      Annotation: 
       Subtype: Link
       Rect: 316, 56, 474, 63
    Page: 
     Label: 509
     Sequence: 13
     Annotations: 
      Annotation: 
       Subtype: Link
       Rect: 57, 730, 293, 737
      Annotation: 
       Subtype: Link
       Rect: 57, 722, 171, 729
      Annotation: 
       Subtype: Link
       Rect: 57, 715, 293, 721
      Annotation: 
       Subtype: Link
       Rect: 57, 707, 277, 713
      Annotation: 
       Subtype: Link
       Rect: 57, 699, 293, 705
      Annotation: 
       Subtype: Link
       Rect: 57, 691, 293, 697
      Annotation: 
       Subtype: Link
       Rect: 57, 683, 293, 689
      Annotation: 
       Subtype: Link
       Rect: 57, 675, 99, 681
      Annotation: 
       Subtype: Link
       Rect: 57, 667, 293, 673
      Annotation: 
       Subtype: Link
       Rect: 57, 659, 242, 665
      Annotation: 
       Subtype: Link
       Rect: 325, 730, 561, 737
      Annotation: 
       Subtype: Link
       Rect: 325, 722, 542, 729
      Annotation: 
       Subtype: Link
       Rect: 325, 715, 561, 721
      Annotation: 
       Subtype: Link
       Rect: 325, 707, 561, 713
      Annotation: 
       Subtype: Link
       Rect: 325, 699, 508, 705
      Annotation: 
       Subtype: Link
       Rect: 456, 683, 561, 689
      Annotation: 
       Subtype: Link
       Rect: 325, 675, 332, 681
  Checksum: 8af12e57
   Type: CRC32
  Checksum: cd3e41ec48fbe1c5d1446ecaaa8dc4a9
   Type: MD5
  Checksum: c48a954cc3d1a1daf735de9570f16f2521a70d2a
   Type: SHA-1