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Eron Subject: Antiviral Research, 170 (2019) 104543. doi:10.1016/j.antiviral.2019.104543 Keywords: Darunavir/cobicistat/emtricitabine/TAF; Single-tablet regimen; Safety; Efficacy; Switch study; Creator: Elsevier CreationDate: Tue Sep 24 13:20:27 CEST 2019 ModDate: Tue Sep 24 13:20:27 CEST 2019 ID: 0xffd36f99949bcd7432934b18afc04bc5, 0x7af1c241f0a8334c8735eb3e3629dcc7 Filters: FilterPipeline: FlateDecode FilterPipeline: DCTDecode Images: Image: NisoImageMetadata: FormatName: image/jpg CompressionScheme: JPEG ImageWidth: 236 ImageHeight: 298 BitsPerSample: 8 BitsPerSampleUnit: integer Image: NisoImageMetadata: FormatName: image/jpg CompressionScheme: JPEG ImageWidth: 247 ImageHeight: 271 BitsPerSample: 8 BitsPerSampleUnit: integer Image: NisoImageMetadata: FormatName: image/jpg CompressionScheme: JPEG ImageWidth: 2012 ImageHeight: 1009 BitsPerSample: 8 BitsPerSampleUnit: integer Image: NisoImageMetadata: FormatName: image/jpg CompressionScheme: JPEG ImageWidth: 1422 ImageHeight: 1568 BitsPerSample: 8 BitsPerSampleUnit: integer Image: NisoImageMetadata: FormatName: image/jpg CompressionScheme: JPEG ImageWidth: 1422 ImageHeight: 1293 BitsPerSample: 8 BitsPerSampleUnit: integer Image: NisoImageMetadata: FormatName: image/jpg CompressionScheme: JPEG ImageWidth: 1422 ImageHeight: 1600 BitsPerSample: 8 BitsPerSampleUnit: integer Fonts: Type0: Font: BaseFont: AMOBEO+CharisSIL Encoding: Identity-H ToUnicode: true Font: BaseFont: LNWPCS+CharisSIL-Italic Encoding: Identity-H ToUnicode: true Type1: Font: BaseFont: PDLHEO+STIXGeneral-Regular FontSubset: true FirstChar: 1 LastChar: 1 FontDescriptor: FontName: PDLHEO+STIXGeneral-Regular Flags: Nonsymbolic FontBBox: -995, -455, 2000, 1055 FontFile3: true EncodingDictionary: BaseEncoding: WinAnsiEncoding Differences: true ToUnicode: true Font: BaseFont: CSWDMU+CharisSIL-Italic FontSubset: true FirstChar: 1 LastChar: 82 FontDescriptor: FontName: CSWDMU+CharisSIL-Italic Flags: Nonsymbolic, Italic FontBBox: -716, -533, 3058, 1270 FontFile3: true EncodingDictionary: BaseEncoding: WinAnsiEncoding Differences: true ToUnicode: true Font: BaseFont: MFDVEA+CharisSIL FontSubset: true FirstChar: 1 LastChar: 109 FontDescriptor: FontName: MFDVEA+CharisSIL Flags: Nonsymbolic FontBBox: -692, -533, 3000, 1270 FontFile3: true EncodingDictionary: BaseEncoding: WinAnsiEncoding Differences: true ToUnicode: true Font: BaseFont: ZALMHE+UniversLTStd FontSubset: true FirstChar: 1 LastChar: 21 FontDescriptor: FontName: ZALMHE+UniversLTStd Flags: Nonsymbolic FontBBox: -168, -250, 992, 947 FontFile3: true EncodingDictionary: BaseEncoding: WinAnsiEncoding Differences: true ToUnicode: true Font: BaseFont: ZIUHRC+CharisSIL-Bold FontSubset: true FirstChar: 1 LastChar: 39 FontDescriptor: FontName: ZIUHRC+CharisSIL-Bold Flags: Nonsymbolic, ForceBold FontBBox: -720, -533, 3000, 1270 FontFile3: true EncodingDictionary: BaseEncoding: WinAnsiEncoding Differences: true ToUnicode: true CIDFontType0: Font: BaseFont: AMOBEO+CharisSIL CIDSystemInfo: Registry: Adobe Registry: Identity Supplement: 0 FontDescriptor: FontName: AMOBEO+CharisSIL Flags: Serif, Symbolic FontBBox: -692, -533, 3000, 1270 FontFile3: true Font: BaseFont: LNWPCS+CharisSIL-Italic CIDSystemInfo: Registry: Adobe Registry: Identity Supplement: 0 FontDescriptor: FontName: LNWPCS+CharisSIL-Italic Flags: Serif, Symbolic, Italic FontBBox: -716, -533, 3058, 1270 FontFile3: true XMP: application/pdf doi:10.1016/j.antiviral.2019.104543 Week 96 efficacy and safety results of the phase 3, randomized EMERALD trial to evaluate switching from boosted-protease inhibitors plus emtricitabine/tenofovir disoproxil fumarate regimens to the once daily, single-tablet regimen of darunavir/cobicistat/emtricitabine/tenofovir alafenamide (D/C/F/TAF) in treatment-experienced, virologically-suppressed adults living with HIV-1 Joseph J. Eron Chloe Orkin Douglas Cunningham Federico Pulido Frank A. Post Stéphane De Wit Erkki Lathouwers Veerle Hufkens John Jezorwski Romana Petrovic Kimberley Brown Erika Van Landuyt Magda Opsomer S. De Wit E. Florence M. Moutschen E. Van Wijngaerden L. Vandekerckhove B. Vandercam J. Brunetta B. Conway M. Klein D. Murphy A. Rachlis S. Shafran S. Walmsley F. Ajana L. Cotte P.-M. Girardy C. Katlama J.-M. Molina I. Poizot-Martin F. Raffi D. Rey J. Reynes E. Teicher Y. Yazdanpanah J. Gasiorowski W. Halota A. Horban A. Piekarska A. Witor J.R. Arribas I. Perez-Valero J. Berenguer J. Casado J.M. Gatell F. Gutierrez M.J. Galindo M.D.M. Gutierrez J.A. Iribarren H. Knobel E. Negredo J.A. Pineda D. Podzamczer J.Portilla Sogorb F. Pulido C. Ricart A. Rivero I. Santos Gil A. Blaxhult L. Flamholc M. Gisslèn A. Thalme J. Fehr A. Rauch M. Stoeckle A. Clarke B.G. Gazzard M.A. Johnson C. Orkin F. Post A. Ustianowski L. Waters J. Bailey P. Benson L. Bhatti I. Brar U.F. Bredeek C. Brinson G. Crofoot D. Cunningham E. DeJesus C. Dietz R. Dretler J. Eron F. Felizarta C. Fichtenbaum J. Gallant J. Gathe D. Hagins S. Henn W.K. Henry G. Huhn M. Jain C. Lucasti C. Martorell C. McDonald A. Mills J. Morales-Ramirez K. Mounzer R. Nahass H. Olivet O. Osiyemi D. Prelutsky M. Ramgopal B. Rashbaum G. Richmond P. Ruane A. Scarsella A. Scribner P. Shalit D. Shamblaw J. Slim K. Tashima G. Voskuhl D. Ward A. Wilkin J. de Vente EMERALD study group Darunavir/cobicistat/emtricitabine/TAF Single-tablet regimen Safety Efficacy Switch study Elsevier Antiviral Research, 170 (2019) 104543. doi:10.1016/j.antiviral.2019.104543 journal Antiviral Research © 2019 The Authors. 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