e1bd2b80ae2325979f60ed333543a8f9 nannanbio_a2019v17p198.pdf cacd7e20cd9403ce10e90d2422f6645587be73d4 nannanbio_a2019v17p198.pdf 59e5ec97506fbd2ec884a74f990bbe244b689774ce4a403fd8ac3381bf09ce14 nannanbio_a2019v17p198.pdf Title: Poly(propylene imine) dendrimers with histidine-maltose shell as novel type of nanoparticles for synapse and memory protection Creator: Elsevier Producer: Acrobat Distiller 10.0.0 (Windows) CreationDate: Wed Apr 10 08:26:03 2019 CEST ModDate: Fri May 10 18:47:00 2019 CEST Tagged: no UserProperties: no Suspects: no Form: none JavaScript: no Pages: 12 Encrypted: no Page size: 576 x 774.028 pts Page rot: 0 File size: 3490750 bytes Optimized: yes PDF version: 1.7 name type encoding emb sub uni object ID ------------------------------------ ----------------- ---------------- --- --- --- --------- BMDJDH+AdvTT6120e2aa Type 1C WinAnsi yes yes no 428 0 BMDJEH+AdvTT6120e2aa+20 Type 1C Custom yes yes yes 429 0 BMDJEI+AdvTT50a2f13e.I Type 1C WinAnsi yes yes no 430 0 BMDJEJ+AdvTTb8864ccf.B Type 1C WinAnsi yes yes no 431 0 BMDJEK+AdvTT6120e2aa+03 Type 1C Custom yes yes yes 432 0 BMDJJJ+Helvetica-Bold Type 1C WinAnsi yes yes no 413 0 BMDKAI+AdvTT6120e2aa+22 Type 1C Custom yes yes no 227 0 BMDKBI+AdvTT50a2f13e.I+20 Type 1C WinAnsi yes yes no 228 0 BMDLHB+AdvTT454a7a89 Type 1C WinAnsi yes yes no 85 0 Jhove (Rel. 1.22.1, 2019-04-17) Date: 2020-08-10 13:07:48 CEST RepresentationInformation: nannanbio_a2019v17p198.pdf ReportingModule: PDF-hul, Rel. 1.12.1 (2019-04-17) LastModified: 2020-07-15 14:24:29 CEST Size: 3490750 Format: PDF Version: 1.7 Status: Well-Formed and valid SignatureMatches: PDF-hul MIMEtype: application/pdf Profile: Linearized PDF PDFMetadata: Objects: 470 FreeObjects: 1 IncrementalUpdates: 1 DocumentCatalog: PageLayout: SinglePage PageMode: UseOutlines Outlines: Item: Title: Poly(propylene imine) dendrimers with histidine-maltose shell as novel type of nanoparticles for synapse and memory protection Destination: edu.harvard.hul.ois.jhove.module.pdf.PdfSimpleObject@4d3167f4 Children: Item: Title: Methods Destination: edu.harvard.hul.ois.jhove.module.pdf.PdfSimpleObject@ed9d034 Children: Item: Title: Reagents Destination: edu.harvard.hul.ois.jhove.module.pdf.PdfSimpleObject@6121c9d6 Item: Title: Synthesis of G4HisMal dendrimer Destination: edu.harvard.hul.ois.jhove.module.pdf.PdfSimpleObject@87f383f Item: Title: Design of experiments in vivo Destination: edu.harvard.hul.ois.jhove.module.pdf.PdfSimpleObject@4eb7f003 Children: Item: Title: BBB cross Destination: edu.harvard.hul.ois.jhove.module.pdf.PdfSimpleObject@eafc191 Item: Title: G4HIsMal treatment Destination: edu.harvard.hul.ois.jhove.module.pdf.PdfSimpleObject@612fc6eb Item: Title: Fluorescent measurements of FITC-G4HisMal in mouse brain tissue extract Destination: edu.harvard.hul.ois.jhove.module.pdf.PdfSimpleObject@1060b431 Item: Title: Double-labeling immunofluorescence and imaging Destination: edu.harvard.hul.ois.jhove.module.pdf.PdfSimpleObject@612679d6 Item: Title: Immunofluorescence quantification Destination: edu.harvard.hul.ois.jhove.module.pdf.PdfSimpleObject@11758f2a Item: Title: Cell culture Destination: edu.harvard.hul.ois.jhove.module.pdf.PdfSimpleObject@e720b71 Item: Title: Statistical analysis Destination: edu.harvard.hul.ois.jhove.module.pdf.PdfSimpleObject@1b26f7b2 Item: Title: Ethical issues Destination: edu.harvard.hul.ois.jhove.module.pdf.PdfSimpleObject@491cc5c9 Item: Title: Results Destination: edu.harvard.hul.ois.jhove.module.pdf.PdfSimpleObject@74ad1f1f Children: Item: Title: Maltose-histidine shell significantly improved the ability of poly(propylene imine) dendrimers to cross BBB Destination: edu.harvard.hul.ois.jhove.module.pdf.PdfSimpleObject@6a1aab78 Item: Title: Long-term G4HisMal treatment protects memory performance in APP-PS1 mice without reducing amyloid plaque load Destination: edu.harvard.hul.ois.jhove.module.pdf.PdfSimpleObject@462d5aee Item: Title: Preventive G4HisMal treatment protects synapses Destination: edu.harvard.hul.ois.jhove.module.pdf.PdfSimpleObject@69b0fd6f Item: Title: Discussion Destination: edu.harvard.hul.ois.jhove.module.pdf.PdfSimpleObject@757942a1 Item: Title: Acknowledgments Destination: edu.harvard.hul.ois.jhove.module.pdf.PdfSimpleObject@4a87761d Item: Title: Appendix A. Supplementary data Destination: edu.harvard.hul.ois.jhove.module.pdf.PdfSimpleObject@66d1af89 Item: Title: References Destination: edu.harvard.hul.ois.jhove.module.pdf.PdfSimpleObject@8646db9 Info: Title: Poly(propylene imine) dendrimers with histidine-maltose shell as novel type of nanoparticles for synapse and memory protection Creator: Elsevier Producer: Acrobat Distiller 10.0.0 (Windows) CreationDate: Wed Apr 10 08:26:03 CEST 2019 ModDate: Fri May 10 18:47:00 CEST 2019 ID: 0xf7b33f39ece230dac46d455b882bf5c8, 0x41e7c95a2adb3769ba55dcfc74d3bdc4 Filters: FilterPipeline: FlateDecode FilterPipeline: DCTDecode FilterPipeline: CCITTFaxDecode Images: Image: NisoImageMetadata: FormatName: image/jpg CompressionScheme: JPEG ImageWidth: 481 ImageHeight: 174 ColorSpace: CMYK BitsPerSample: 8 BitsPerSampleUnit: integer Image: NisoImageMetadata: FormatName: image/tiff CompressionScheme: CCITT 1D ImageWidth: 735 ImageHeight: 818 BitsPerSample: 1 BitsPerSampleUnit: integer ImageMask: true Image: NisoImageMetadata: FormatName: image/jpg CompressionScheme: JPEG ImageWidth: 2089 ImageHeight: 2056 ColorSpace: RGB BitsPerSample: 8 BitsPerSampleUnit: integer Image: NisoImageMetadata: FormatName: image/jpg CompressionScheme: JPEG ImageWidth: 1896 ImageHeight: 1531 ColorSpace: RGB BitsPerSample: 8 BitsPerSampleUnit: integer Image: NisoImageMetadata: FormatName: image/jpg CompressionScheme: JPEG ImageWidth: 2132 ImageHeight: 1224 ColorSpace: RGB BitsPerSample: 8 BitsPerSampleUnit: integer Image: NisoImageMetadata: FormatName: image/jpg CompressionScheme: JPEG ImageWidth: 1660 ImageHeight: 1742 ColorSpace: RGB BitsPerSample: 8 BitsPerSampleUnit: integer Image: NisoImageMetadata: FormatName: image/jpg CompressionScheme: JPEG ImageWidth: 1482 ImageHeight: 904 ColorSpace: RGB BitsPerSample: 8 BitsPerSampleUnit: integer Image: NisoImageMetadata: FormatName: image/jpg CompressionScheme: JPEG ImageWidth: 1660 ImageHeight: 1512 ColorSpace: black is zero BitsPerSample: 8 BitsPerSampleUnit: integer Fonts: Type1: Font: BaseFont: BMDJEK+AdvTT6120e2aa+03 FontSubset: true FirstChar: 1 LastChar: 3 FontDescriptor: FontName: BMDJEK+AdvTT6120e2aa+03 Flags: Symbolic FontBBox: -812, -281, 1052, 885 FontFile3: true EncodingDictionary: Differences: true ToUnicode: true Font: BaseFont: BMDKAI+AdvTT6120e2aa+22 FontSubset: true FirstChar: 21 LastChar: 21 FontDescriptor: FontName: BMDKAI+AdvTT6120e2aa+22 Flags: Nonsymbolic FontBBox: 19, -270, 1312, 1020 FontFile3: true EncodingDictionary: BaseEncoding: WinAnsiEncoding Differences: true Font: BaseFont: BMDKBI+AdvTT50a2f13e.I+20 FontSubset: true FirstChar: 150 LastChar: 150 FontDescriptor: FontName: BMDKBI+AdvTT50a2f13e.I+20 Flags: Nonsymbolic FontBBox: -312, -218, 1770, 843 FontFile3: true Encoding: WinAnsiEncoding Font: BaseFont: BMDLHB+AdvTT454a7a89 FontSubset: true FirstChar: 98 LastChar: 98 FontDescriptor: FontName: BMDLHB+AdvTT454a7a89 Flags: Nonsymbolic FontBBox: -52, -208, 968, 802 FontFile3: true Encoding: WinAnsiEncoding Font: BaseFont: BMDJDH+AdvTT6120e2aa FontSubset: true FirstChar: 37 LastChar: 252 FontDescriptor: FontName: BMDJDH+AdvTT6120e2aa Flags: Serif, Nonsymbolic FontBBox: -72, -208, 1052, 875 FontFile3: true Encoding: WinAnsiEncoding Font: BaseFont: BMDJJJ+Helvetica-Bold FontSubset: true FirstChar: 32 LastChar: 83 FontDescriptor: FontName: BMDJJJ+Helvetica-Bold Flags: Nonsymbolic, ForceBold FontBBox: -170, -228, 1003, 962 FontFile3: true Encoding: WinAnsiEncoding Font: BaseFont: BMDJEH+AdvTT6120e2aa+20 FontSubset: true FirstChar: 1 LastChar: 144 FontDescriptor: FontName: BMDJEH+AdvTT6120e2aa+20 Flags: Symbolic FontBBox: -572, -208, 1291, 843 FontFile3: true EncodingDictionary: Differences: true ToUnicode: true Font: BaseFont: BMDJEI+AdvTT50a2f13e.I FontSubset: true FirstChar: 39 LastChar: 242 FontDescriptor: FontName: BMDJEI+AdvTT50a2f13e.I Flags: Serif, Nonsymbolic FontBBox: -166, -208, 916, 947 FontFile3: true Encoding: WinAnsiEncoding Font: BaseFont: BMDJEJ+AdvTTb8864ccf.B FontSubset: true FirstChar: 46 LastChar: 121 FontDescriptor: FontName: BMDJEJ+AdvTTb8864ccf.B Flags: Nonsymbolic FontBBox: -20, -208, 989, 885 FontFile3: true Encoding: WinAnsiEncoding XMP: application/pdf Poly(propylene imine) dendrimers with histidine-maltose shell as novel type of nanoparticles for synapse and memory protection Ester Aso PhD Isak Martinsson MSc Dietmar Appelhans PhD Christiane Effenberg MSc Nuria Benseny-Cases PhD Josep Cladera PhD Gunnar Gouras MD PhD Isidre Ferrer MD PhD Oxana Klementieva PhD Dendrimers Histidine Maltose Biocompatibility Amyloid Synapses Nanomedicine: Nanotechnology, Biology, and Medicine, 17 (2019) 198-209. doi:10.1016/j.nano.2019.01.010 journal Nanomedicine: Nanotechnology, Biology, and Medicine (c) 2019 The Authors All rights reserved The Authors 1549-9634 17 C April 2019 2019-04 198-209 198 209 10.1016/j.nano.2019.01.010 https://doi.org/10.1016/j.nano.2019.01.010 doi:10.1016/j.nano.2019.01.010 2010-04-23 true 10.1016/j.nano.2019.01.010 elsevier.com sciencedirect.com VoR 10.1016/j.nano.2019.01.010 noindex 2010-04-23 true elsevier.com sciencedirect.com Elsevier True Dendrimers; Histidine; Maltose; Biocompatibility; Amyloid; Synapses Pages: Page: Label: 198 Sequence: 1 Annotations: Annotation: Subtype: Link Rect: 448, 350, 534, 359 Annotation: Subtype: Link Rect: 32, 339, 125, 348 Annotation: Subtype: Link Rect: 60, 193, 61, 203 Destination: 205 Annotation: Subtype: Link Rect: 61, 197, 66, 207 Destination: 205 Annotation: Subtype: Link Rect: 61, 197, 66, 207 Destination: 205 Annotation: Subtype: Link Rect: 355, 228, 356, 237 Destination: 205 Annotation: Subtype: Link Rect: 356, 232, 368, 241 Destination: 205 Annotation: Subtype: Link Rect: 356, 232, 368, 241 Destination: 205 Annotation: Subtype: Link Rect: 523, 216, 524, 226 Destination: 205 Annotation: Subtype: Link Rect: 524, 220, 534, 230 Destination: 205 Annotation: Subtype: Link Rect: 524, 220, 534, 230 Destination: 205 Annotation: Subtype: Link Rect: 128, 697, 156, 725 Annotation: Subtype: Link Rect: 192, 697, 374, 705 Annotation: Subtype: Link Rect: 251, 687, 298, 695 Annotation: Subtype: Link Rect: 251, 687, 304, 695 Annotation: Subtype: Link Rect: 251, 687, 315, 695 Annotation: Subtype: Link Rect: 33, 666, 86, 725 Annotation: Subtype: Link Rect: 418, 684, 533, 725 Annotation: Subtype: Link Rect: 98, 73, 194, 81 Annotation: Subtype: Link Rect: 32, 55, 168, 63 Annotation: Subtype: Link Rect: 445, 45, 534, 53 Annotation: Subtype: Link Rect: 32, 35, 102, 43 Annotation: Subtype: Link Rect: 233, 8, 369, 16 Page: Label: 199 Sequence: 2 Annotations: Annotation: Subtype: Link Rect: 233, 619, 234, 629 Destination: 205 Annotation: Subtype: Link Rect: 234, 623, 238, 633 Destination: 205 Annotation: Subtype: Link Rect: 234, 623, 238, 633 Destination: 205 Annotation: Subtype: Link Rect: 189, 596, 190, 606 Destination: 205 Annotation: Subtype: Link Rect: 190, 601, 194, 610 Destination: 205 Annotation: Subtype: Link Rect: 190, 601, 194, 610 Destination: 205 Annotation: Subtype: Link Rect: 150, 562, 151, 571 Destination: 205 Annotation: Subtype: Link Rect: 151, 566, 166, 576 Destination: 205 Annotation: Subtype: Link Rect: 151, 566, 166, 576 Destination: 205 Annotation: Subtype: Link Rect: 112, 550, 113, 560 Destination: 205 Annotation: Subtype: Link Rect: 113, 555, 121, 564 Destination: 205 Annotation: Subtype: Link Rect: 113, 555, 121, 564 Destination: 205 Annotation: Subtype: Link Rect: 274, 493, 275, 503 Destination: 205 Annotation: Subtype: Link Rect: 275, 497, 283, 507 Destination: 205 Annotation: Subtype: Link Rect: 275, 497, 283, 507 Destination: 205 Annotation: Subtype: Link Rect: 247, 447, 248, 457 Destination: 205 Annotation: Subtype: Link Rect: 248, 452, 256, 461 Destination: 205 Annotation: Subtype: Link Rect: 248, 452, 256, 461 Destination: 205 Annotation: Subtype: Link Rect: 171, 436, 172, 445 Destination: 205 Annotation: Subtype: Link Rect: 172, 440, 180, 450 Destination: 205 Annotation: Subtype: Link Rect: 172, 440, 180, 450 Destination: 205 Annotation: Subtype: Link Rect: 226, 413, 227, 422 Destination: 205 Annotation: Subtype: Link Rect: 227, 417, 235, 427 Destination: 205 Annotation: Subtype: Link Rect: 227, 417, 235, 427 Destination: 205 Annotation: Subtype: Link Rect: 136, 402, 137, 411 Destination: 205 Annotation: Subtype: Link Rect: 137, 406, 145, 415 Destination: 205 Annotation: Subtype: Link Rect: 137, 406, 145, 415 Destination: 205 Annotation: Subtype: Link Rect: 274, 379, 275, 388 Destination: 205 Annotation: Subtype: Link Rect: 275, 383, 283, 392 Destination: 205 Annotation: Subtype: Link Rect: 275, 383, 283, 392 Destination: 205 Annotation: Subtype: Link Rect: 184, 68, 185, 77 Destination: 205 Annotation: Subtype: Link Rect: 185, 72, 193, 82 Destination: 205 Annotation: Subtype: Link Rect: 185, 72, 193, 82 Destination: 205 Annotation: Subtype: Link Rect: 152, 45, 208, 54 Destination: 205 Annotation: Subtype: Link Rect: 439, 68, 440, 77 Destination: 205 Annotation: Subtype: Link Rect: 440, 72, 448, 82 Destination: 205 Annotation: Subtype: Link Rect: 440, 72, 448, 82 Destination: 205 Annotation: Subtype: Link Rect: 405, 56, 438, 66 Destination: 44 Page: Label: 200 Sequence: 3 Annotations: Annotation: Subtype: Link Rect: 247, 179, 248, 187 Destination: 222 Annotation: Subtype: Link Rect: 248, 182, 254, 190 Destination: 222 Annotation: Subtype: Link Rect: 248, 182, 254, 190 Destination: 222 Annotation: Subtype: Link Rect: 423, 169, 424, 177 Destination: 222 Annotation: Subtype: Link Rect: 424, 172, 430, 180 Destination: 222 Annotation: Subtype: Link Rect: 424, 172, 430, 180 Destination: 222 Page: Label: 201 Sequence: 4 Annotations: Annotation: Subtype: Link Rect: 216, 519, 217, 528 Destination: 205 Annotation: Subtype: Link Rect: 217, 523, 225, 533 Destination: 205 Annotation: Subtype: Link Rect: 217, 523, 225, 533 Destination: 205 Annotation: Subtype: Link Rect: 170, 330, 171, 340 Destination: 205 Annotation: Subtype: Link Rect: 171, 335, 179, 344 Destination: 205 Annotation: Subtype: Link Rect: 171, 335, 179, 344 Destination: 205 Annotation: Subtype: Link Rect: 255, 245, 256, 254 Destination: 205 Annotation: Subtype: Link Rect: 256, 249, 264, 259 Destination: 205 Annotation: Subtype: Link Rect: 256, 249, 264, 259 Destination: 205 Annotation: Subtype: Link Rect: 403, 546, 404, 556 Destination: 205 Annotation: Subtype: Link Rect: 404, 550, 412, 560 Destination: 205 Annotation: Subtype: Link Rect: 404, 550, 412, 560 Destination: 205 Annotation: Subtype: Link Rect: 529, 535, 530, 544 Destination: 205 Annotation: Subtype: Link Rect: 530, 539, 537, 548 Destination: 205 Annotation: Subtype: Link Rect: 530, 539, 537, 548 Destination: 205 Annotation: Subtype: Link Rect: 378, 217, 379, 226 Destination: 205 Annotation: Subtype: Link Rect: 379, 221, 396, 230 Destination: 205 Annotation: Subtype: Link Rect: 379, 221, 396, 230 Destination: 205 Annotation: Subtype: Link Rect: 402, 217, 434, 226 Destination: 44 Annotation: Subtype: Link Rect: 304, 79, 336, 89 Destination: 44 Annotation: Subtype: Link Rect: 534, 45, 535, 54 Destination: 205 Annotation: Subtype: Link Rect: 535, 49, 543, 59 Destination: 205 Annotation: Subtype: Link Rect: 535, 49, 543, 59 Destination: 205 Page: Label: 202 Sequence: 5 Annotations: Annotation: Subtype: Link Rect: 238, 160, 239, 169 Destination: 205 Annotation: Subtype: Link Rect: 239, 164, 246, 174 Destination: 205 Annotation: Subtype: Link Rect: 239, 164, 246, 174 Destination: 205 Annotation: Subtype: Link Rect: 443, 183, 444, 192 Destination: 205 Annotation: Subtype: Link Rect: 444, 187, 452, 197 Destination: 205 Annotation: Subtype: Link Rect: 444, 187, 452, 197 Destination: 205 Annotation: Subtype: Link Rect: 480, 103, 516, 112 Destination: 88 Page: Label: 203 Sequence: 6 Annotations: Annotation: Subtype: Link Rect: 262, 654, 263, 663 Destination: 205 Annotation: Subtype: Link Rect: 263, 658, 271, 667 Destination: 205 Annotation: Subtype: Link Rect: 263, 658, 271, 667 Destination: 205 Annotation: Subtype: Link Rect: 108, 619, 140, 629 Destination: 88 Annotation: Subtype: Link Rect: 171, 459, 203, 468 Destination: 88 Annotation: Subtype: Link Rect: 149, 402, 150, 411 Destination: 205 Annotation: Subtype: Link Rect: 150, 406, 166, 415 Destination: 205 Annotation: Subtype: Link Rect: 150, 406, 166, 415 Destination: 205 Annotation: Subtype: Link Rect: 209, 344, 244, 354 Destination: 88 Annotation: Subtype: Link Rect: 128, 298, 161, 308 Destination: 88 Annotation: Subtype: Link Rect: 220, 276, 221, 285 Destination: 205 Annotation: Subtype: Link Rect: 221, 280, 229, 289 Destination: 205 Annotation: Subtype: Link Rect: 221, 280, 229, 289 Destination: 205 Annotation: Subtype: Link Rect: 199, 114, 200, 123 Destination: 205 Annotation: Subtype: Link Rect: 200, 118, 208, 127 Destination: 205 Annotation: Subtype: Link Rect: 200, 118, 208, 127 Destination: 205 Annotation: Subtype: Link Rect: 184, 68, 185, 77 Destination: 205 Annotation: Subtype: Link Rect: 185, 72, 193, 82 Destination: 205 Annotation: Subtype: Link Rect: 185, 72, 193, 82 Destination: 205 Annotation: Subtype: Link Rect: 485, 631, 522, 640 Destination: 143 Annotation: Subtype: Link Rect: 518, 608, 543, 617 Destination: 143 Annotation: Subtype: Link Rect: 301, 596, 306, 606 Destination: 143 Annotation: Subtype: Link Rect: 534, 550, 535, 560 Destination: 205 Annotation: Subtype: Link Rect: 535, 555, 543, 564 Destination: 205 Annotation: Subtype: Link Rect: 535, 555, 543, 564 Destination: 205 Annotation: Subtype: Link Rect: 385, 505, 417, 514 Destination: 143 Annotation: Subtype: Link Rect: 316, 436, 317, 445 Destination: 205 Annotation: Subtype: Link Rect: 317, 440, 334, 450 Destination: 205 Annotation: Subtype: Link Rect: 317, 440, 334, 450 Destination: 205 Annotation: Subtype: Link Rect: 443, 379, 476, 388 Destination: 150 Annotation: Subtype: Link Rect: 414, 356, 415, 365 Destination: 205 Annotation: Subtype: Link Rect: 415, 360, 432, 369 Destination: 205 Annotation: Subtype: Link Rect: 415, 360, 432, 369 Destination: 205 Annotation: Subtype: Link Rect: 304, 333, 337, 342 Destination: 150 Annotation: Subtype: Link Rect: 475, 321, 540, 331 Destination: 143 Annotation: Subtype: Link Rect: 304, 195, 336, 205 Destination: 162 Page: Label: 204 Sequence: 7 Rotate: 90 Page: Label: 205 Sequence: 8 Annotations: Annotation: Subtype: Link Rect: 44, 160, 76, 169 Destination: 162 Annotation: Subtype: Link Rect: 364, 183, 365, 192 Destination: 205 Annotation: Subtype: Link Rect: 365, 187, 382, 196 Destination: 205 Annotation: Subtype: Link Rect: 365, 187, 382, 196 Destination: 205 Annotation: Subtype: Link Rect: 389, 137, 420, 146 Destination: 196 Page: Label: 206 Sequence: 9 Annotations: Annotation: Subtype: Link Rect: 194, 251, 195, 261 Destination: 205 Annotation: Subtype: Link Rect: 195, 255, 205, 265 Destination: 205 Annotation: Subtype: Link Rect: 195, 255, 205, 265 Destination: 205 Annotation: Subtype: Link Rect: 64, 148, 65, 158 Destination: 205 Annotation: Subtype: Link Rect: 65, 152, 82, 162 Destination: 205 Annotation: Subtype: Link Rect: 65, 152, 82, 162 Destination: 205 Annotation: Subtype: Link Rect: 154, 114, 155, 123 Destination: 205 Annotation: Subtype: Link Rect: 155, 118, 163, 127 Destination: 205 Annotation: Subtype: Link Rect: 155, 118, 163, 127 Destination: 205 Annotation: Subtype: Link Rect: 102, 91, 103, 100 Destination: 205 Annotation: Subtype: Link Rect: 103, 95, 111, 104 Destination: 205 Annotation: Subtype: Link Rect: 103, 95, 111, 104 Destination: 205 Annotation: Subtype: Link Rect: 484, 217, 485, 226 Destination: 205 Annotation: Subtype: Link Rect: 485, 221, 489, 231 Destination: 205 Annotation: Subtype: Link Rect: 485, 221, 489, 231 Destination: 205 Annotation: Subtype: Link Rect: 451, 194, 452, 203 Destination: 205 Annotation: Subtype: Link Rect: 452, 198, 460, 208 Destination: 205 Annotation: Subtype: Link Rect: 452, 198, 460, 208 Destination: 205 Annotation: Subtype: Link Rect: 372, 171, 373, 181 Destination: 205 Annotation: Subtype: Link Rect: 373, 175, 381, 185 Destination: 205 Annotation: Subtype: Link Rect: 373, 175, 381, 185 Destination: 205 Annotation: Subtype: Link Rect: 362, 148, 363, 158 Destination: 222 Annotation: Subtype: Link Rect: 363, 152, 371, 162 Destination: 222 Annotation: Subtype: Link Rect: 363, 152, 371, 162 Destination: 222 Annotation: Subtype: Link Rect: 398, 79, 399, 89 Destination: 205 Annotation: Subtype: Link Rect: 399, 84, 412, 93 Destination: 205 Annotation: Subtype: Link Rect: 399, 84, 412, 93 Destination: 205 Page: Label: 207 Sequence: 10 Annotations: Annotation: Subtype: Link Rect: 301, 45, 463, 54 Page: Label: 208 Sequence: 11 Annotations: Annotation: Subtype: Link Rect: 506, 681, 534, 689 Annotation: Subtype: Link Rect: 306, 671, 368, 679 Annotation: Subtype: Link Rect: 505, 462, 534, 470 Annotation: Subtype: Link Rect: 306, 452, 372, 460 Annotation: Subtype: Link Rect: 438, 203, 534, 211 Annotation: Subtype: Link Rect: 306, 193, 311, 201 Page: Label: 209 Sequence: 12 Checksum: 7d93ffe7 Type: CRC32 Checksum: e1bd2b80ae2325979f60ed333543a8f9 Type: MD5 Checksum: cacd7e20cd9403ce10e90d2422f6645587be73d4 Type: SHA-1