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A pilot study Subject: Translational Research, 210 (2019) 8-25. doi:10.1016/j.trsl.2019.03.002 Author: Adrian Villalba Creator: Elsevier Producer: Acrobat Distiller 10.1.16 (Windows) CreationDate: Tue Jun 4 05:49:57 2019 CEST ModDate: Tue Jun 4 05:50:28 2019 CEST Tagged: yes UserProperties: no Suspects: no Form: none JavaScript: no Pages: 18 Encrypted: no Page size: 593.858 x 792 pts Page rot: 0 File size: 2712329 bytes Optimized: yes PDF version: 1.7 name type encoding emb sub uni object ID ------------------------------------ ----------------- ---------------- --- --- --- --------- LPDMPB+AdvP697C Type 1C Custom yes yes no 426 0 LPDMNP+AdvP4C4E74 Type 1C Custom yes yes yes 430 0 LPDMNN+AdvP49A570 Type 1C WinAnsi yes yes no 435 0 LPDMNO+AdvPAEB7 Type 1C WinAnsi yes yes no 438 0 LPDMHN+AdvP85AC Type 1C WinAnsi yes yes no 441 0 LPDMNM+AdvPAEB6 Type 1C MacRoman yes yes no 444 0 LPDMOA+AdvP6F00 Type 1C MacRoman yes yes no 447 0 LPDMNL+AdvPAEB4 Type 1C MacRoman yes yes no 450 0 LPDNAC+AdvP6F0B Type 1C WinAnsi yes yes no 271 0 LPDNBE+AdvPi3 Type 1C WinAnsi yes yes no 274 0 LPDNBD+AdvP4C9543 Type 1C WinAnsi yes yes no 277 0 LPDNAD+AdvP4C9542 Type 1C WinAnsi yes yes no 280 0 LPDNBF+AdvPAEB5 Type 1C WinAnsi yes yes no 283 0 LPDNCG+AdvTT488bbd95+02 Type 1C Custom yes yes yes 36 0 LPEHJD+AdvTT488bbd95+20 Type 1C Custom yes yes yes 286 0 LPDODA+AdvP6F01 Type 1C WinAnsi yes yes no 291 0 LPEKMA+AdvP4C4E59 Type 1C Custom yes yes yes 294 0 LPGBKK+AdvP8648 Type 1C WinAnsi yes yes no 217 0 Jhove (Rel. 1.22.1, 2019-04-17) Date: 2021-03-30 02:44:04 CEST RepresentationInformation: 223023.pdf ReportingModule: PDF-hul, Rel. 1.12.1 (2019-04-17) LastModified: 2021-03-29 09:40:29 CEST Size: 2712329 Format: PDF Version: 1.7 Status: Well-Formed and valid SignatureMatches: PDF-hul MIMEtype: application/pdf Profile: Linearized PDF PDFMetadata: Objects: 526 FreeObjects: 1 IncrementalUpdates: 1 DocumentCatalog: ViewerPreferences: HideToolbar: false HideMenubar: false HideWindowUI: false FitWindow: false CenterWindow: false DisplayDocTitle: true NonFullScreenPageMode: UseNone Direction: L2R ViewArea: CropBox ViewClip: CropBox PrintArea: CropBox PageClip: CropBox PageLayout: SinglePage PageMode: UseOutlines Outlines: Item: Title: Partial remission and early stages of pediatric type 1 diabetes display immunoregulatory changes. A pilot study Destination: edu.harvard.hul.ois.jhove.module.pdf.PdfSimpleObject@1060b431 Children: Item: Title: INTRODUCTION Destination: edu.harvard.hul.ois.jhove.module.pdf.PdfSimpleObject@612679d6 Item: Title: MATERIAL AND METHODS Destination: edu.harvard.hul.ois.jhove.module.pdf.PdfSimpleObject@11758f2a Children: Item: Title: Participants Destination: edu.harvard.hul.ois.jhove.module.pdf.PdfSimpleObject@e720b71 Item: Title: ELISA Destination: edu.harvard.hul.ois.jhove.module.pdf.PdfSimpleObject@1b26f7b2 Item: Title: Flow cytometry Destination: edu.harvard.hul.ois.jhove.module.pdf.PdfSimpleObject@491cc5c9 Item: Title: Quantitative RT-PCR Destination: edu.harvard.hul.ois.jhove.module.pdf.PdfSimpleObject@74ad1f1f Item: Title: Statistical analysis Destination: edu.harvard.hul.ois.jhove.module.pdf.PdfSimpleObject@6a1aab78 Item: Title: RESULTS Destination: edu.harvard.hul.ois.jhove.module.pdf.PdfSimpleObject@462d5aee Children: Item: Title: Clinical features of pediatric patients with T1D throughout the study Destination: edu.harvard.hul.ois.jhove.module.pdf.PdfSimpleObject@69b0fd6f Item: Title: Circulating TGF-β levels decrease during PR stage Destination: edu.harvard.hul.ois.jhove.module.pdf.PdfSimpleObject@757942a1 Item: Title: Plasmatic concentration of betatrophin is increased in pediatric patients with T1D Destination: edu.harvard.hul.ois.jhove.module.pdf.PdfSimpleObject@4a87761d Item: Title: Immune response-related molecules are altered at the onset of T1D Destination: edu.harvard.hul.ois.jhove.module.pdf.PdfSimpleObject@66d1af89 Item: Title: Regulatory leukocyte subsets are biomarkers of T1D onset and progression stages Destination: edu.harvard.hul.ois.jhove.module.pdf.PdfSimpleObject@8646db9 Item: Title: Low circulating monocyte count is associated with T1D onset and second year of progression Destination: edu.harvard.hul.ois.jhove.module.pdf.PdfSimpleObject@37374a5e Item: Title: B lymphocyte subsets are quantitatively altered at the onset and at early stages of T1D progression Destination: edu.harvard.hul.ois.jhove.module.pdf.PdfSimpleObject@4671e53b Item: Title: T lymphocyte subsets are quantitatively altered at the onset and at early stages of diabetes progression Destination: edu.harvard.hul.ois.jhove.module.pdf.PdfSimpleObject@2db7a79b Item: Title: DISCUSSION Destination: edu.harvard.hul.ois.jhove.module.pdf.PdfSimpleObject@6950e31 Children: Item: Title: Acknowledgments Destination: edu.harvard.hul.ois.jhove.module.pdf.PdfSimpleObject@b7dd107 Item: Title: Author contributions Destination: edu.harvard.hul.ois.jhove.module.pdf.PdfSimpleObject@42eca56e Item: Title: Conflict of interest statement Destination: edu.harvard.hul.ois.jhove.module.pdf.PdfSimpleObject@52f759d7 Item: Title: Funding Destination: edu.harvard.hul.ois.jhove.module.pdf.PdfSimpleObject@7cbd213e Item: Title: Supplementary materials Destination: edu.harvard.hul.ois.jhove.module.pdf.PdfSimpleObject@192d3247 Children: Item: Title: REFERENCES Destination: edu.harvard.hul.ois.jhove.module.pdf.PdfSimpleObject@3ecd23d9 Info: Title: Partial remission and early stages of pediatric type 1 diabetes display immunoregulatory changes. 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Translational Research, 210 (2019) 8-25. doi:10.1016/j.trsl.2019.03.002 Partial remission and early stages of pediatric type 1 diabetes display immunoregulatory changes. A pilot study Adrian Villalba Mireia Fonolleda Marta Murillo Silvia Rodriguez-Fernandez Rosa-Maria Ampudia David Perna-Barrull Maria Belen Raina Bibiana Quirant-Sanchez Raquel Planas Aina Teniente-Serra Joan Bel Marta Vives-Pi uuid:fd8cfc10-4791-4a8b-8025-00abb91efa0c uuid:f37b504f-dbfa-4af2-ac3f-33fef8811bef journal © 2019 The Author(s). Published by Elsevier Inc. 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