afe8d9ca3883fc79ec4fb734a2dacbff stecel_a2019m4v37n4p476.pdf 561891f6fd51383163d280f788abb66a894760d9 stecel_a2019m4v37n4p476.pdf 3e73665940a2493d6e29686a59f7104423ebfd8cd0efa684a5d8d7aa6ff49553 stecel_a2019m4v37n4p476.pdf Title: Global Proteomic and Methylome Analysis in Human Induced Pluripotent Stem Cells Reveals Overexpression of a Human TLR3 Affecting Proper Innate Immune Response Signaling Subject: STEM CELLS 2019.37:476-488 Creator: Arbortext Advanced Print Publisher 9.1.520/W Unicode Producer: Acrobat Distiller 11.0 (Windows); modified using iText 4.2.0 by 1T3XT CreationDate: Thu Mar 21 08:57:07 2019 CET ModDate: Wed Jun 10 16:16:13 2020 CEST Tagged: no UserProperties: no Suspects: no Form: none JavaScript: no Pages: 13 Encrypted: no Page size: 595.276 x 790.866 pts Page rot: 0 File size: 2918033 bytes Optimized: no PDF version: 1.7 name type encoding emb sub uni object ID ------------------------------------ ----------------- ---------------- --- --- --- --------- NJJGCP+AdvTT06f3545d.I Type 1C WinAnsi yes yes no 31 0 NJJGDA+AdvTT06f3545d.I+20 Type 1C WinAnsi yes yes no 213 0 NJJFNL+AdvTT2ffda40f.B Type 1C WinAnsi yes yes no 17 0 NJJGBK+AdvTT7b515deb Type 1C WinAnsi yes yes no 18 0 NJJGBL+AdvTT7b515deb+20 Type 1C WinAnsi yes yes no 19 0 NJJGCM+AdvTT7b515deb+fb Type 1C Custom yes yes yes 20 0 NJJGCN+AdvTT2ffda40f.B+fb Type 1C Custom yes yes yes 35 0 NJJGCO+AdvOT385dc4d7 Type 1C WinAnsi yes yes no 21 0 NJJGOO+AdvTT26e64a0d.BI+fb Type 1C Custom yes yes yes 14 0 NJJGOP+AdvP4C4E74 Type 1C Custom yes yes yes 15 0 NJJGON+AdvTT26e64a0d.BI Type 1C WinAnsi yes yes no 16 0 NJJHCA+AdvOT8608a8d1+03 Type 1C Custom yes yes yes 32 0 NJJHCB+AdvOT8608a8d1 Type 1C WinAnsi yes yes no 33 0 NJJHAP+AdvOT8608a8d1+22 Type 1C Custom yes yes no 34 0 NJJHBA+AdvTT2ffda40f.B+20 Type 1C WinAnsi yes yes no 36 0 NJJHFB+AdvTT06f3545d.I+fb Type 1C Custom yes yes yes 46 0 NJJHFC+AdvTT7b515deb+22 Type 1C Custom yes yes yes 47 0 Jhove (Rel. 1.22.1, 2019-04-17) Date: 2020-08-10 13:07:34 CEST RepresentationInformation: stecel_a2019m4v37n4p476.pdf ReportingModule: PDF-hul, Rel. 1.12.1 (2019-04-17) LastModified: 2020-06-10 16:17:38 CEST Size: 2918033 Format: PDF Version: 1.7 Status: Well-Formed and valid SignatureMatches: PDF-hul MIMEtype: application/pdf PDFMetadata: Objects: 0 FreeObjects: 2 IncrementalUpdates: 0 DocumentCatalog: PageLayout: SinglePage PageMode: UseNone Outlines: Item: Title: Global Proteomic and Methylome Analysis inHuman Induced Pluripotent Stem Cells Reveals Overexpression of a Human TLR3 Affe... Destination: edu.harvard.hul.ois.jhove.module.pdf.PdfSimpleObject@74ad1f1f Children: Item: Title: Introduction Destination: edu.harvard.hul.ois.jhove.module.pdf.PdfSimpleObject@6a1aab78 Item: Title: Materials and Methods Destination: edu.harvard.hul.ois.jhove.module.pdf.PdfSimpleObject@462d5aee Children: Item: Title: iPSC Cell Culture Destination: edu.harvard.hul.ois.jhove.module.pdf.PdfSimpleObject@69b0fd6f Item: Title: Proteomic Analysis for Global and MHC-1 Peptide Analysis Destination: edu.harvard.hul.ois.jhove.module.pdf.PdfSimpleObject@757942a1 Children: Item: Title: Protein Solubilization and Quantification Destination: edu.harvard.hul.ois.jhove.module.pdf.PdfSimpleObject@4a87761d Item: Title: Peptides Preparation and Labeling with Isobaric Tags (Tandem Mass Tag 10-Plex) Destination: edu.harvard.hul.ois.jhove.module.pdf.PdfSimpleObject@66d1af89 Item: Title: Liquid Chromatography-Tandem Mass Spectrometry Destination: edu.harvard.hul.ois.jhove.module.pdf.PdfSimpleObject@8646db9 Item: Title: Protein Identification and Quantification Destination: edu.harvard.hul.ois.jhove.module.pdf.PdfSimpleObject@37374a5e Item: Title: Illumina Infinium Methylation EPIC BeadChip Destination: edu.harvard.hul.ois.jhove.module.pdf.PdfSimpleObject@4671e53b Item: Title: Bisulfite Pyrosequencing Destination: edu.harvard.hul.ois.jhove.module.pdf.PdfSimpleObject@2db7a79b Item: Title: Sequencing Destination: edu.harvard.hul.ois.jhove.module.pdf.PdfSimpleObject@6950e31 Item: Title: Lipopolysaccharide and Poly (I:C) Stimulation Destination: edu.harvard.hul.ois.jhove.module.pdf.PdfSimpleObject@b7dd107 Item: Title: Cytoplasmic and Nuclear Protein Fraction Extraction Destination: edu.harvard.hul.ois.jhove.module.pdf.PdfSimpleObject@42eca56e Item: Title: Illuminex Cytokine Detection Array Destination: edu.harvard.hul.ois.jhove.module.pdf.PdfSimpleObject@52f759d7 Item: Title: Lentiviral Production Destination: edu.harvard.hul.ois.jhove.module.pdf.PdfSimpleObject@7cbd213e Item: Title: Western Blot Destination: edu.harvard.hul.ois.jhove.module.pdf.PdfSimpleObject@192d3247 Item: Title: Flow Cytometry Destination: edu.harvard.hul.ois.jhove.module.pdf.PdfSimpleObject@3ecd23d9 Item: Title: Real Time PCR Destination: edu.harvard.hul.ois.jhove.module.pdf.PdfSimpleObject@569cfc36 Item: Title: Statistical Analyses Destination: edu.harvard.hul.ois.jhove.module.pdf.PdfSimpleObject@43bd930a Item: Title: Results Destination: edu.harvard.hul.ois.jhove.module.pdf.PdfSimpleObject@33723e30 Children: Item: Title: Global Proteomic Analysis of Patient (F1) and iPSC-Derived Fibroblasts (F2) Destination: edu.harvard.hul.ois.jhove.module.pdf.PdfSimpleObject@64f6106c Item: Title: Characterization of Adaptive and Innate Immune System in Human iPSC Destination: edu.harvard.hul.ois.jhove.module.pdf.PdfSimpleObject@553a3d88 Item: Title: Human TLR3 Isoform Transcription Start Site Is Hypomethylated in Human iPSC-Derived Cells and Exclusively Expressed in Humans Destination: edu.harvard.hul.ois.jhove.module.pdf.PdfSimpleObject@7a30d1e6 Item: Title: Human TLR3 Isoform Is Overexpressed in Most Human iPSC-Derived Cells Not Seen in Normal Human Tissue or Cells Destination: edu.harvard.hul.ois.jhove.module.pdf.PdfSimpleObject@5891e32e Item: Title: Human TLR3 Isoform Functions to Suppress NF-KB p65 Signaling Pathway in Response to Virus (Poly IC) Destination: edu.harvard.hul.ois.jhove.module.pdf.PdfSimpleObject@cb0ed20 Item: Title: Discussion Destination: edu.harvard.hul.ois.jhove.module.pdf.PdfSimpleObject@8e24743 Item: Title: Ethical Statement Destination: edu.harvard.hul.ois.jhove.module.pdf.PdfSimpleObject@74a10858 Item: Title: Acknowledgments Destination: edu.harvard.hul.ois.jhove.module.pdf.PdfSimpleObject@23fe1d71 Item: Title: Author Contributions Destination: edu.harvard.hul.ois.jhove.module.pdf.PdfSimpleObject@28ac3dc3 Item: Title: Disclosure of Potential Conflicts of Interest Destination: edu.harvard.hul.ois.jhove.module.pdf.PdfSimpleObject@32eebfca 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