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Keywords: rheumatoid arthritis, genomics, transcriptomics, multi-omics association analysis, anti-TNF therapy Author: Antonio Julià Creator: LaTeX with hyperref package + hypdvips Producer: dvips + MiKTeX GPL Ghostscript 9.0 CreationDate: Sat Jun 29 14:21:15 2019 CEST ModDate: Sat Jun 29 15:50:34 2019 CEST Tagged: no UserProperties: no Suspects: no Form: none JavaScript: no Pages: 13 Encrypted: no Page size: 595.26 x 779.52 pts Page rot: 0 File size: 999332 bytes Optimized: no PDF version: 1.4 name type encoding emb sub uni object ID ------------------------------------ ----------------- ---------------- --- --- --- --------- WAQLLX+HelveticaNeueLTStd-MdIt Type 1C WinAnsi yes yes no 73 0 YEYKUS+HelveticaNeueLTStd-LtIt Type 1C Custom yes yes no 68 0 RTJZSA+HelveticaNeueLTStd-BdIt Type 1C WinAnsi yes yes no 66 0 URYTEP+HelveticaNeueLTStd-Lt Type 1C Custom yes yes no 49 0 DUITKE+HelveticaNeueLTStd-Bd Type 1C Custom yes yes no 44 0 TTIQUN+MinionPro-It Type 1C WinAnsi yes yes no 109 0 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Keywords: rheumatoid arthritis, genomics, transcriptomics, multi-omics association analysis, anti-TNF therapy Creator: LaTeX with hyperref package + hypdvips Producer: dvips + MiKTeX GPL Ghostscript 9.0 CreationDate: Sat Jun 29 14:51:15 CEST 2019 ModDate: Sat Jun 29 16:20:34 CEST 2019 ID: 0x5aaaa9a11ae1fda1dc7368979b975471, 0xfd053955872f794094ef1f93a34a6b7a Filters: FilterPipeline: FlateDecode FilterPipeline: DCTDecode Images: Image: NisoImageMetadata: FormatName: image/jpg CompressionScheme: JPEG ImageWidth: 1890 ImageHeight: 1826 BitsPerSample: 8 BitsPerSampleUnit: integer Interpolate: true Image: NisoImageMetadata: FormatName: image/jpg CompressionScheme: JPEG ImageWidth: 2835 ImageHeight: 2538 BitsPerSample: 8 BitsPerSampleUnit: integer Interpolate: true Fonts: Type1: Font: BaseFont: RTJZSA+HelveticaNeueLTStd-BdIt FontSubset: true FirstChar: 42 LastChar: 121 FontDescriptor: FontName: RTJZSA+HelveticaNeueLTStd-BdIt Flags: Nonsymbolic FontBBox: -63, -182, 717, 731 FontFile3: true Encoding: WinAnsiEncoding Font: BaseFont: VQSNMS+MinionPro-Bold FontSubset: true FirstChar: 3 LastChar: 117 FontDescriptor: FontName: VQSNMS+MinionPro-Bold Flags: Symbolic FontBBox: 0, -244, 823, 703 FontFile3: true EncodingDictionary: BaseEncoding: WinAnsiEncoding Differences: true Font: BaseFont: YEYKUS+HelveticaNeueLTStd-LtIt FontSubset: true FirstChar: 0 LastChar: 243 FontDescriptor: FontName: YEYKUS+HelveticaNeueLTStd-LtIt Flags: Symbolic FontBBox: -137, -206, 978, 729 FontFile3: true EncodingDictionary: BaseEncoding: WinAnsiEncoding Differences: true Font: BaseFont: AZUWQU+MTSYB FontSubset: true FirstChar: 6 LastChar: 6 FontDescriptor: FontName: AZUWQU+MTSYB Flags: Symbolic FontBBox: 0, 0, 724, 668 FontFile3: true EncodingDictionary: BaseEncoding: WinAnsiEncoding Differences: true Font: BaseFont: WAQLLX+HelveticaNeueLTStd-MdIt FontSubset: true FirstChar: 42 LastChar: 250 FontDescriptor: FontName: WAQLLX+HelveticaNeueLTStd-MdIt Flags: Symbolic FontBBox: -133, -205, 891, 731 FontFile3: true Encoding: WinAnsiEncoding Font: BaseFont: DUITKE+HelveticaNeueLTStd-Bd FontSubset: true FirstChar: 0 LastChar: 124 FontDescriptor: FontName: DUITKE+HelveticaNeueLTStd-Bd Flags: Symbolic FontBBox: -9, -214, 848, 786 FontFile3: true EncodingDictionary: BaseEncoding: WinAnsiEncoding Differences: true Font: BaseFont: TTIQUN+MinionPro-It FontSubset: true FirstChar: 40 LastChar: 243 FontDescriptor: FontName: TTIQUN+MinionPro-It Flags: Symbolic FontBBox: -142, -257, 903, 712 FontFile3: true Encoding: WinAnsiEncoding Font: BaseFont: AOZEBI+MTGU FontSubset: true FirstChar: 98 LastChar: 109 FontDescriptor: FontName: AOZEBI+MTGU Flags: Symbolic FontBBox: 0, -196, 607, 683 FontFile3: true EncodingDictionary: BaseEncoding: WinAnsiEncoding Differences: true Font: BaseFont: URYTEP+HelveticaNeueLTStd-Lt FontSubset: true FirstChar: 0 LastChar: 239 FontDescriptor: FontName: URYTEP+HelveticaNeueLTStd-Lt Flags: Symbolic FontBBox: -30, -214, 904, 786 FontFile3: true EncodingDictionary: BaseEncoding: WinAnsiEncoding Differences: true Font: BaseFont: QMQJXH+RMTMI FontSubset: true FirstChar: 12 LastChar: 62 FontDescriptor: FontName: QMQJXH+RMTMI Flags: Symbolic FontBBox: 0, -199, 683, 671 FontFile3: true EncodingDictionary: BaseEncoding: WinAnsiEncoding Differences: true Font: BaseFont: GOCLZO+MTSY FontSubset: true FirstChar: 0 LastChar: 68 FontDescriptor: FontName: GOCLZO+MTSY Flags: Symbolic FontBBox: 0, -83, 724, 668 FontFile3: true EncodingDictionary: BaseEncoding: WinAnsiEncoding Differences: true ToUnicode: true Font: BaseFont: UHBUGX+MinionPro-Regular FontSubset: true FirstChar: 2 LastChar: 243 FontDescriptor: FontName: UHBUGX+MinionPro-Regular Flags: Symbolic FontBBox: -26, -257, 956, 713 FontFile3: true EncodingDictionary: BaseEncoding: WinAnsiEncoding Differences: true Font: BaseFont: QNXIOM+HelveticaNeueLTStd-Md FontSubset: true FirstChar: 0 LastChar: 121 FontDescriptor: FontName: QNXIOM+HelveticaNeueLTStd-Md Flags: Symbolic FontBBox: 0, -205, 938, 731 FontFile3: true EncodingDictionary: BaseEncoding: WinAnsiEncoding Differences: true XMP: dvips + MiKTeX GPL Ghostscript 9.0 rheumatoid arthritis, genomics, transcriptomics, multi-omics association analysis, anti-TNF therapy 2019-06-29T19:20:34+05:30 2019-06-29T17:51:15+05:30 LaTeX with hyperref package + hypdvips 2019-06-29T19:20:34+05:30 e3981a3c-9cc3-11e9-0000-b68ef850cd4b uuid:034383e7-bafc-4c32-bef8-9b275a7d78dc application/pdf A Combined Transcriptomic and Genomic Analysis Identifies a Gene Signature Associated With the Response to Anti-TNF Therapy in Rheumatoid Arthritis Antonio Julià Background: Rheumatoid arthritis (RA) is the most frequent autoimmune disease involving the joints. 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External Annotation: Subtype: Link Rect: 43, 29, 117, 37 Annotation: Subtype: Link Rect: 120, 29, 180, 37 Annotation: Subtype: Link Rect: 441, 29, 551, 38 Page: Label: 6 Sequence: 6 Annotations: Annotation: Subtype: Link Rect: 61, 310, 96, 318 Destination: External Annotation: Subtype: Link Rect: 84, 264, 114, 273 Destination: External Annotation: Subtype: Link Rect: 219, 135, 254, 144 Destination: External Annotation: Subtype: Link Rect: 142, 101, 172, 110 Destination: External Annotation: Subtype: Link Rect: 93, 67, 123, 75 Destination: External Annotation: Subtype: Link Rect: 349, 291, 379, 300 Destination: External Annotation: Subtype: Link Rect: 381, 291, 416, 300 Destination: External Annotation: Subtype: Link Rect: 418, 289, 457, 299 Destination: External Annotation: Subtype: Link Rect: 378, 255, 413, 265 Destination: External Annotation: Subtype: Link Rect: 496, 186, 535, 196 Destination: External Annotation: Subtype: Link Rect: 43, 29, 117, 37 Annotation: Subtype: Link Rect: 120, 29, 180, 37 Annotation: Subtype: Link Rect: 441, 29, 551, 38 Page: Label: 7 Sequence: 7 Annotations: Annotation: Subtype: Link Rect: 427, 640, 438, 651 Destination: External Annotation: Subtype: Link Rect: 442, 640, 453, 651 Destination: External Annotation: Subtype: Link Rect: 484, 594, 495, 605 Destination: External Annotation: Subtype: Link Rect: 388, 548, 399, 559 Destination: External Annotation: Subtype: Link Rect: 509, 525, 520, 536 Destination: External Annotation: Subtype: Link Rect: 435, 410, 446, 422 Destination: External Annotation: Subtype: Link Rect: 405, 365, 416, 376 Destination: External Annotation: Subtype: Link Rect: 419, 365, 430, 376 Destination: External Annotation: Subtype: Link Rect: 534, 342, 546, 353 Destination: External Annotation: Subtype: Link Rect: 460, 273, 471, 284 Destination: External Annotation: Subtype: Link Rect: 474, 273, 485, 284 Destination: External Annotation: Subtype: Link Rect: 326, 147, 338, 158 Destination: External Annotation: Subtype: Link Rect: 340, 147, 352, 158 Destination: External Annotation: Subtype: Link Rect: 452, 124, 464, 135 Destination: External Annotation: Subtype: Link Rect: 465, 124, 477, 135 Destination: External Annotation: Subtype: Link Rect: 429, 101, 440, 113 Destination: External Annotation: Subtype: Link Rect: 522, 67, 533, 78 Destination: External Annotation: Subtype: Link Rect: 43, 29, 117, 37 Annotation: Subtype: Link Rect: 120, 29, 180, 37 Annotation: Subtype: Link Rect: 441, 29, 551, 38 Page: Label: 8 Sequence: 8 Annotations: Annotation: Subtype: Link Rect: 123, 248, 152, 255 Destination: External Annotation: Subtype: Link Rect: 139, 181, 150, 193 Destination: External Annotation: Subtype: Link Rect: 221, 101, 232, 113 Destination: External Annotation: Subtype: Link Rect: 78, 78, 89, 90 Destination: External Annotation: Subtype: Link Rect: 94, 78, 105, 90 Destination: External Annotation: Subtype: Link Rect: 509, 708, 520, 720 Destination: External Annotation: Subtype: Link Rect: 409, 674, 420, 685 Destination: External Annotation: Subtype: Link Rect: 480, 662, 491, 674 Destination: External Annotation: Subtype: Link Rect: 494, 662, 509, 674 Destination: External Annotation: Subtype: Link Rect: 353, 628, 368, 640 Destination: External Annotation: Subtype: Link Rect: 373, 628, 389, 640 Destination: External Annotation: Subtype: Link Rect: 488, 617, 504, 628 Destination: External Annotation: Subtype: Link Rect: 431, 548, 442, 559 Destination: External Annotation: Subtype: Link Rect: 444, 548, 460, 559 Destination: External Annotation: Subtype: Link Rect: 445, 170, 461, 181 Destination: External Annotation: Subtype: Link Rect: 464, 170, 480, 181 Destination: External Annotation: Subtype: Link Rect: 43, 29, 117, 37 Annotation: Subtype: Link Rect: 120, 29, 180, 37 Annotation: Subtype: Link Rect: 441, 29, 551, 38 Page: Label: 9 Sequence: 9 Annotations: Annotation: Subtype: Link Rect: 214, 243, 230, 254 Destination: External Annotation: Subtype: Link Rect: 43, 29, 117, 37 Annotation: Subtype: Link Rect: 120, 29, 180, 37 Annotation: Subtype: Link Rect: 441, 29, 551, 38 Page: Label: 10 Sequence: 10 Annotations: Annotation: Subtype: Link Rect: 552, 624, 303, 649 Annotation: Subtype: Link Rect: 112, 554, 177, 561 Annotation: Subtype: Link Rect: 112, 534, 211, 542 Annotation: Subtype: Link Rect: 153, 515, 231, 523 Annotation: Subtype: Link Rect: 74, 469, 151, 476 Annotation: Subtype: Link Rect: 131, 440, 205, 448 Annotation: Subtype: Link Rect: 292, 391, 60, 411 Annotation: Subtype: Link Rect: 129, 354, 230, 362 Annotation: Subtype: Link Rect: 104, 316, 204, 325 Annotation: Subtype: Link Rect: 171, 287, 265, 296 Annotation: Subtype: Link Rect: 104, 241, 160, 249 Annotation: Subtype: Link Rect: 74, 204, 139, 211 Annotation: Subtype: Link Rect: 74, 156, 151, 164 Annotation: Subtype: Link Rect: 151, 107, 226, 116 Annotation: Subtype: Link Rect: 125, 69, 218, 79 Annotation: Subtype: Link Rect: 334, 554, 382, 561 Annotation: Subtype: Link Rect: 500, 516, 549, 523 Annotation: Subtype: Link Rect: 502, 487, 550, 495 Annotation: Subtype: Link Rect: 334, 448, 427, 457 Annotation: Subtype: Link Rect: 334, 402, 423, 410 Annotation: Subtype: Link Rect: 393, 374, 458, 381 Annotation: Subtype: Link Rect: 368, 334, 429, 343 Annotation: Subtype: Link Rect: 413, 297, 506, 306 Annotation: Subtype: Link Rect: 334, 260, 443, 268 Annotation: Subtype: Link Rect: 392, 222, 478, 230 Annotation: Subtype: Link Rect: 390, 183, 450, 192 Annotation: Subtype: Link Rect: 334, 137, 434, 145 Annotation: Subtype: Link Rect: 334, 90, 390, 97 Annotation: Subtype: Link Rect: 43, 28, 117, 36 Annotation: Subtype: Link Rect: 120, 28, 180, 36 Annotation: Subtype: Link Rect: 441, 28, 551, 37 Page: Label: 11 Sequence: 11 Annotations: Annotation: Subtype: Link Rect: 146, 699, 220, 706 Annotation: Subtype: Link Rect: 108, 661, 193, 668 Annotation: Subtype: Link Rect: 190, 621, 245, 630 Annotation: Subtype: Link Rect: 165, 585, 275, 593 Annotation: Subtype: Link Rect: 101, 547, 172, 554 Annotation: Subtype: Link Rect: 74, 508, 143, 517 Annotation: Subtype: Link Rect: 231, 479, 280, 488 Annotation: Subtype: Link Rect: 226, 460, 278, 469 Annotation: Subtype: Link Rect: 221, 434, 286, 441 Annotation: Subtype: Link Rect: 195, 405, 271, 413 Annotation: Subtype: Link Rect: 184, 375, 265, 384 Annotation: Subtype: Link Rect: 190, 347, 241, 356 Annotation: Subtype: Link Rect: 74, 301, 193, 309 Annotation: Subtype: Link Rect: 129, 271, 221, 280 Annotation: Subtype: Link Rect: 133, 225, 242, 233 Annotation: Subtype: Link Rect: 74, 187, 148, 195 Annotation: Subtype: Link Rect: 74, 148, 139, 157 Annotation: Subtype: Link Rect: 292, 110, 60, 130 Annotation: Subtype: Link Rect: 334, 699, 408, 706 Annotation: Subtype: Link Rect: 334, 669, 396, 678 Annotation: Subtype: Link Rect: 334, 632, 433, 640 Annotation: Subtype: Link Rect: 345, 602, 430, 612 Annotation: Subtype: Link Rect: 368, 576, 434, 583 Annotation: Subtype: Link Rect: 499, 555, 551, 564 Annotation: Subtype: Link Rect: 334, 528, 413, 536 Annotation: Subtype: Link Rect: 334, 500, 409, 507 Annotation: Subtype: Link Rect: 410, 470, 487, 479 Annotation: Subtype: Link Rect: 399, 432, 464, 441 Annotation: Subtype: Link Rect: 478, 404, 528, 413 Annotation: Subtype: Link Rect: 475, 385, 545, 394 Annotation: Subtype: Link Rect: 414, 358, 479, 365 Annotation: Subtype: Link Rect: 334, 328, 387, 337 Annotation: Subtype: Link Rect: 488, 309, 551, 318 Annotation: Subtype: Link Rect: 334, 271, 411, 280 Annotation: Subtype: Link Rect: 357, 235, 442, 242 Annotation: Subtype: Link Rect: 334, 197, 443, 205 Annotation: Subtype: Link Rect: 444, 167, 525, 176 Annotation: Subtype: Link Rect: 334, 129, 427, 138 Annotation: Subtype: Link Rect: 423, 101, 487, 110 Annotation: Subtype: Link Rect: 43, 29, 117, 37 Annotation: Subtype: Link Rect: 120, 29, 180, 37 Annotation: Subtype: Link Rect: 441, 29, 551, 38 Page: Label: 12 Sequence: 12 Annotations: Annotation: Subtype: Link Rect: 74, 699, 168, 706 Annotation: Subtype: Link Rect: 180, 680, 242, 687 Annotation: Subtype: Link Rect: 74, 650, 139, 659 Annotation: Subtype: Link Rect: 133, 623, 227, 631 Annotation: Subtype: Link Rect: 212, 604, 289, 611 Annotation: Subtype: Link Rect: 74, 576, 136, 583 Annotation: Subtype: Link Rect: 150, 546, 201, 554 Annotation: Subtype: Link Rect: 164, 519, 233, 526 Annotation: Subtype: Link Rect: 157, 490, 222, 498 Annotation: Subtype: Link Rect: 74, 451, 135, 460 Annotation: Subtype: Link Rect: 74, 424, 172, 432 Annotation: Subtype: Link Rect: 171, 385, 264, 394 Annotation: Subtype: Link Rect: 126, 358, 209, 366 Annotation: Subtype: Link Rect: 74, 318, 178, 328 Annotation: Subtype: Link Rect: 184, 290, 256, 299 Annotation: Subtype: Link Rect: 74, 263, 127, 271 Annotation: Subtype: Link Rect: 74, 224, 178, 233 Annotation: Subtype: Link Rect: 74, 178, 130, 185 Annotation: Subtype: Link Rect: 104, 129, 197, 138 Annotation: Subtype: Link Rect: 74, 102, 124, 110 Annotation: Subtype: Link Rect: 74, 74, 122, 81 Annotation: Subtype: Link Rect: 334, 687, 412, 696 Annotation: Subtype: Link Rect: 417, 659, 510, 668 Annotation: Subtype: Link Rect: 368, 623, 424, 630 Annotation: Subtype: Link Rect: 334, 593, 428, 602 Annotation: Subtype: Link Rect: 334, 547, 390, 554 Annotation: Subtype: Link Rect: 334, 508, 416, 517 Annotation: Subtype: Link Rect: 393, 471, 449, 479 Annotation: Subtype: Link Rect: 393, 434, 449, 441 Annotation: Subtype: Link Rect: 419, 394, 505, 403 Annotation: Subtype: Link Rect: 486, 376, 538, 384 Annotation: Subtype: Link Rect: 396, 348, 444, 356 Annotation: Subtype: Link Rect: 552, 299, 320, 319 Annotation: Subtype: Link Rect: 372, 263, 428, 271 Annotation: Subtype: Link Rect: 334, 235, 446, 242 Annotation: Subtype: Link Rect: 334, 206, 443, 214 Annotation: Subtype: Link Rect: 334, 167, 427, 176 Annotation: Subtype: Link Rect: 334, 121, 443, 129 Annotation: Subtype: Link Rect: 334, 93, 399, 100 Annotation: Subtype: Link Rect: 43, 29, 117, 37 Annotation: Subtype: Link Rect: 120, 29, 180, 37 Annotation: Subtype: Link Rect: 441, 29, 551, 38 Page: Label: 13 Sequence: 13 Annotations: Annotation: Subtype: Link Rect: 74, 699, 159, 706 Annotation: Subtype: Link Rect: 292, 660, 60, 679 Annotation: Subtype: Link Rect: 292, 622, 60, 641 Annotation: Subtype: Link Rect: 146, 593, 216, 602 Annotation: Subtype: Link Rect: 74, 555, 155, 564 Annotation: Subtype: Link Rect: 334, 697, 423, 706 Annotation: Subtype: Link Rect: 446, 669, 535, 678 Annotation: Subtype: Link Rect: 422, 585, 448, 592 Annotation: Subtype: Link Rect: 448, 585, 480, 592 Annotation: Subtype: Link Rect: 479, 585, 515, 592 Annotation: Subtype: Link Rect: 514, 585, 537, 592 Annotation: Subtype: Link Rect: 552, 573, 303, 593 Annotation: Subtype: Link Rect: 43, 29, 117, 37 Annotation: Subtype: Link Rect: 120, 29, 180, 37 Annotation: Subtype: Link Rect: 441, 29, 551, 38 Checksum: 1ad3dd0d Type: CRC32 Checksum: f6b7b910b3c9dbaf04fba9d71875bd76 Type: MD5 Checksum: c70569bbaa0caeed0eec5801f537e77822212345 Type: SHA-1