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Keywords: Dasatinib, lymphocytosis, CCR7, migration, chronic myeloid leukemia Author: Beatriz Colom-Fernández Creator: Adobe InDesign CC 2015 (Windows) Producer: Adobe PDF Library 15.0 CreationDate: Mon Nov 25 13:37:00 2019 CET ModDate: Mon Nov 25 13:59:05 2019 CET Tagged: yes UserProperties: no Suspects: no Form: none JavaScript: no Pages: 11 Encrypted: no Page size: 595.276 x 779.528 pts Page rot: 0 File size: 2094576 bytes Optimized: no PDF version: 1.4 name type encoding emb sub uni object ID ------------------------------------ ----------------- ---------------- --- --- --- --------- HelveticaNeueLTStd-Bd Type 1C Custom yes no yes 939 0 HelveticaNeueLTStd-BdIt Type 1C WinAnsi yes no yes 940 0 HelveticaNeueLTStd-LtIt Type 1C Custom yes no yes 941 0 HelveticaNeueLTStd-MdIt Type 1C WinAnsi yes no yes 951 0 HelveticaNeueLTStd-Lt Type 1C Custom yes no yes 953 0 MinionProMTC-Regular Type 1C Custom yes no yes 152 0 MinionProMTC-Italic Type 1C Custom yes no yes 147 0 QZJAFR+STIXGeneral Type 1C WinAnsi yes yes yes 171 0 MinionPro-Bold Type 1C Custom yes no yes 170 0 Jhove (Rel. 1.22.1, 2019-04-17) Date: 2021-03-03 02:22:26 CET RepresentationInformation: 223215.pdf ReportingModule: PDF-hul, Rel. 1.12.1 (2019-04-17) LastModified: 2021-03-01 17:04:37 CET Size: 2094576 Format: PDF Version: 1.4 Status: Well-Formed, but not valid SignatureMatches: PDF-hul ID: PDF-HUL-122 ErrorMessage: edu.harvard.hul.ois.jhove.module.pdf.PdfMalformedException: Invalid character in hex string Offset: 2050734 ID: PDF-HUL-122 ErrorMessage: edu.harvard.hul.ois.jhove.module.pdf.PdfMalformedException: Invalid character in hex string Offset: 2050734 ID: PDF-HUL-122 ErrorMessage: edu.harvard.hul.ois.jhove.module.pdf.PdfMalformedException: Invalid character in hex string Offset: 2050734 MIMEtype: application/pdf PDFMetadata: Objects: 1019 FreeObjects: 789 IncrementalUpdates: 3 DocumentCatalog: ViewerPreferences: HideToolbar: false HideMenubar: false HideWindowUI: false FitWindow: false CenterWindow: false DisplayDocTitle: false NonFullScreenPageMode: UseNone Direction: L2R ViewArea: CropBox ViewClip: CropBox PrintArea: CropBox PageClip: CropBox PageLayout: SinglePage PageMode: UseOutlines Outlines: Item: Title: Immediate Effects of Dasatinib on the Migration and Redistribution of Naïve and Memory Lymphocytes Associated With Lymphocytosis in Chronic Myeloid Leukemia Patients Children: Item: Title: Introduction Item: Title: Patients and Methods Children: Item: Title: Study Patients and Samples Item: Title: Immunophenotyping Item: Title: Migration Assay Item: Title: Statistical Analyses Item: Title: Results Children: Item: Title: Dasatinib Intake Inhibits the Migratory Capacity of T-Lymphocytes Item: Title: The First Dasatinib Intake Influences CCR7 Expression on T-Lymphocytes Item: Title: Dasatinib Favors the Accumulation of Effector T-Cells and Memory B-Cells in Peripheral Blood Item: Title: A Minority of Patients Do Not Show Increased Absolute Lymphocyte Counts After Dasatinib Intake Item: Title: Discussion and Conclusion Item: Title: Data Availability Statement Item: Title: Ethics Statement Item: Title: Author Contributions Item: Title: Funding Item: Title: Acknowledgments Item: Title: References Info: Title: Immediate Effects of Dasatinib on the Migration and Redistribution of Naïve and Memory Lymphocytes Associated With Lymphocytosis in Chronic Myeloid Leukemia Patients Author: Beatriz Colom-Fernández Subject: Dasatinib is a dual SRC/ABL tyrosine kinase inhibitor used to treat chronic myeloid leukemia (CML) that is known to have unique immunomodulatory effects. Keywords: Dasatinib, lymphocytosis, CCR7, migration, chronic myeloid leukemia Creator: Adobe InDesign CC 2015 (Windows) Producer: Adobe PDF Library 15.0 CreationDate: Mon Nov 25 13:37:00 CET 2019 ModDate: Mon Nov 25 13:59:05 CET 2019 ID: 0xae98451cdb0b25408da88ac88989511d, 0x16056fec26182d4480693e4f7a310c59 Filters: FilterPipeline: FlateDecode FilterPipeline: DCTDecode Images: Image: NisoImageMetadata: FormatName: image/jpg CompressionScheme: JPEG ImageWidth: 1772 ImageHeight: 1938 ColorSpace: RGB BitsPerSample: 8 BitsPerSampleUnit: integer Intent: RelativeColorimetric Name: X Image: NisoImageMetadata: FormatName: image/png ImageWidth: 1772 ImageHeight: 1684 ColorSpace: RGB BitsPerSample: 8 BitsPerSampleUnit: integer Filter: FlateDecode Intent: RelativeColorimetric Name: X Image: NisoImageMetadata: FormatName: image/png ImageWidth: 1772 ImageHeight: 2208 ColorSpace: RGB BitsPerSample: 8 BitsPerSampleUnit: integer Filter: FlateDecode Intent: RelativeColorimetric Name: X Image: NisoImageMetadata: FormatName: image/png ImageWidth: 1772 ImageHeight: 1790 ColorSpace: RGB BitsPerSample: 8 BitsPerSampleUnit: integer Filter: FlateDecode Intent: RelativeColorimetric Name: X Fonts: Type1: Font: BaseFont: MinionProMTC-Italic FirstChar: 0 LastChar: 255 FontDescriptor: FontName: MinionProMTC-Italic Flags: Serif, Nonsymbolic FontBBox: -201, -360, 1684, 1002 FontFile3: true EncodingDictionary: BaseEncoding: WinAnsiEncoding Differences: true ToUnicode: true Font: BaseFont: HelveticaNeueLTStd-MdIt FirstChar: 0 LastChar: 255 FontDescriptor: FontName: HelveticaNeueLTStd-MdIt Flags: Nonsymbolic, Italic FontBBox: -165, -218, 1125, 947 FontFile3: true Encoding: WinAnsiEncoding ToUnicode: true Font: BaseFont: MinionProMTC-Regular FirstChar: 0 LastChar: 255 FontDescriptor: FontName: MinionProMTC-Regular Flags: Serif, Nonsymbolic FontBBox: -290, -360, 1684, 989 FontFile3: true EncodingDictionary: BaseEncoding: WinAnsiEncoding Differences: true ToUnicode: true Font: BaseFont: HelveticaNeueLTStd-Lt FirstChar: 0 LastChar: 255 FontDescriptor: FontName: HelveticaNeueLTStd-Lt Flags: Nonsymbolic FontBBox: -166, -295, 1050, 967 FontFile3: true EncodingDictionary: BaseEncoding: WinAnsiEncoding Differences: true ToUnicode: true Font: BaseFont: MinionPro-Bold FirstChar: 0 LastChar: 255 FontDescriptor: FontName: MinionPro-Bold Flags: Serif, Nonsymbolic FontBBox: -319, -360, 1684, 1024 FontFile3: true EncodingDictionary: BaseEncoding: WinAnsiEncoding Differences: true ToUnicode: true Font: BaseFont: HelveticaNeueLTStd-Bd FirstChar: 0 LastChar: 255 FontDescriptor: FontName: HelveticaNeueLTStd-Bd Flags: Nonsymbolic FontBBox: -166, -387, 1078, 975 FontFile3: true EncodingDictionary: BaseEncoding: WinAnsiEncoding Differences: true ToUnicode: true Font: BaseFont: QZJAFR+STIXGeneral FontSubset: true FirstChar: 153 LastChar: 153 FontDescriptor: FontName: QZJAFR+STIXGeneral Flags: Serif, Nonsymbolic FontBBox: -178, -443, 2000, 1023 FontFile3: true Encoding: WinAnsiEncoding ToUnicode: true Font: BaseFont: HelveticaNeueLTStd-BdIt FirstChar: 0 LastChar: 255 FontDescriptor: FontName: HelveticaNeueLTStd-BdIt Flags: Nonsymbolic FontBBox: -166, -393, 1129, 975 FontFile3: true Encoding: WinAnsiEncoding ToUnicode: true Font: BaseFont: HelveticaNeueLTStd-LtIt FirstChar: 0 LastChar: 255 FontDescriptor: FontName: HelveticaNeueLTStd-LtIt Flags: Nonsymbolic FontBBox: -165, -303, 1099, 951 FontFile3: true EncodingDictionary: BaseEncoding: WinAnsiEncoding Differences: true ToUnicode: true XMP: application/pdf Immediate Effects of Dasatinib on the Migration and Redistribution of Naïve and Memory Lymphocytes Associated With Lymphocytosis in Chronic Myeloid Leukemia Patients Dasatinib is a dual SRC/ABL tyrosine kinase inhibitor used to treat chronic myeloid leukemia (CML) that is known to have unique immunomodulatory effects. Beatriz Colom-Fernández Anna Kreutzman Ana Marcos-Jiménez Valentín García-Gutiérrez Carlos Cuesta-Mateos Itxaso Portero-Sainz Yaiza Pérez-García Luis Felipe Casado Fermín Sánchez-Guijo Joaquín Martínez-López Rosa M. Ayala Concha Boqué Blanca Dasatinib lymphocytosis CCR7 migration chronic myeloid leukemia 2019-11-25T20:37+08:00 2019-11-25T20:59:05+08:00 2019-11-25T20:59:05+08:00 Adobe InDesign CC 2015 (Windows) uuid:2889135f-d090-47de-836e-de1773ca0944 xmp.did:2aecd8bd-cbd3-4539-b083-9de383973cbe xmp.id:4f111162-09f6-874b-94ce-3b73422a8699 proof:pdf xmp.iid:83008efe-eaf2-d54e-b8ac-825dc0b6f8fc xmp.did:142e1b35-3140-7845-933c-312a73d69131 xmp.did:2aecd8bd-cbd3-4539-b083-9de383973cbe default converted from application/x-indesign to application/pdf Adobe InDesign CC 2015 (Windows) / 2019-11-25T20:37+08:00 Adobe PDF Library 15.0 False Dasatinib, lymphocytosis, CCR7, migration, chronic myeloid leukemia Pages: Page: Sequence: 1 Annotations: Annotation: Subtype: Link Rect: 84, 521, 160, 510 Annotation: Subtype: Link Rect: 74, 372, 158, 363 Annotation: Subtype: Link Rect: 77, 73, 158, 64 Annotation: Subtype: Link Rect: 175, 622, 520, 593 Annotation: Subtype: Link Rect: 175, 599, 530, 570 Annotation: 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