cea15632cdd299c839474c5a8d653f58 223339.pdf 690b868079deeecd22ab9b4616ec2e8cd8e929bd 223339.pdf 612b06d1b8b241f4b46843bbe1d554d42d04ee425254a191b470758c0ea397cc 223339.pdf Title: Fibroadipogenic progenitors are responsible for muscle loss in limb girdle muscular dystrophy 2B Subject: Nature Communications, doi:10.1038/s41467-019-10438-z Keywords: Author: Marshall W. Hogarth Creator: Springer Producer: iText® 5.3.5 ©2000-2012 1T3XT BVBA (AGPL-version) CreationDate: Fri Jun 14 16:57:03 2019 CEST ModDate: Mon Jun 17 16:04:10 2019 CEST Tagged: no UserProperties: no Suspects: no Form: AcroForm JavaScript: no Pages: 13 Encrypted: no Page size: 595.276 x 782.362 pts Page rot: 0 File size: 6997748 bytes Optimized: no PDF version: 1.4 name type encoding emb sub uni object ID ------------------------------------ ----------------- ---------------- --- --- --- --------- KMGFPL+AdvOTea1a7398 Type 1C WinAnsi yes yes no 101 0 KMGGGK+AdvOTea1a7398+fb Type 1C Custom yes yes yes 135 0 KMGGGL+AdvOTea1a7398+20 Type 1C WinAnsi yes yes no 136 0 KMGGGM+AdvOTcb88df00 Type 1C WinAnsi yes yes no 103 0 Arial-BoldMT Type 1C WinAnsi yes no no 697 0 KMGGMM+AdvOTf23bb480 Type 1C WinAnsi yes yes no 698 0 KMGGNN+AdvTTda6f6cb8.B Type 1C WinAnsi yes yes no 108 0 KMGGMN+AdvOTf23bb480+20 Type 1C WinAnsi yes yes no 699 0 KMGHCN+AdvOT1ef757c0 Type 1C WinAnsi yes yes no 102 0 KMGHCO+AdvOT1ef757c0+fb Type 1C Custom yes yes yes 104 0 KMGHEB+AdvOT1ef757c0+03 Type 1C Custom yes yes yes 105 0 KMGHCM+AdvOT125c650c Type 1C WinAnsi yes yes no 106 0 KMGHFC+AdvOT7d6df7ab.I Type 1C WinAnsi yes yes no 107 0 KMGHDP+AdvTTab7e17fd Type 1C WinAnsi yes yes no 109 0 KMGHEA+AdvOT1ef757c0+20 Type 1C Custom yes yes yes 110 0 KMGHGC+AdvOTb65e897d.B Type 1C WinAnsi yes yes no 111 0 KMHGGK+AdvOT8608a8d1 Type 1C WinAnsi yes yes no 137 0 KMHGHL+AdvOT9bd21c25.I Type 1C WinAnsi yes yes no 138 0 KMHEGE+Helvetica-Bold Type 1C WinAnsi yes yes no 139 0 KMHEHF+Symbol Type 1C Custom yes yes yes 140 0 KMHEAG+Helvetica Type 1C WinAnsi yes yes no 141 0 KMHGJL+AdvTTab7e17fd+22 Type 1C Custom yes yes no 180 0 KMHGJM+AdvOTb65e897d.B+fb Type 1C Custom yes yes yes 181 0 Helvetica2 Type 1C WinAnsi yes no no 182 0 MyriadPro-Regular Type 1C WinAnsi yes no no 183 0 KMIAIC+AdvOT8608a8d1+03 Type 1C Custom yes yes yes 184 0 KMKHNC+AdvOT8608a8d1+22 Type 1C Custom yes yes yes 293 0 KMKOEL+AdvOTb65e897d.B+20 Type 1C WinAnsi yes yes no 505 0 Jhove (Rel. 1.22.1, 2019-04-17) Date: 2021-01-30 02:33:21 CET RepresentationInformation: 223339.pdf ReportingModule: PDF-hul, Rel. 1.12.1 (2019-04-17) LastModified: 2021-01-29 22:08:26 CET Size: 6997748 Format: PDF Version: 1.4 Status: Well-Formed, but not valid SignatureMatches: PDF-hul ID: PDF-HUL-122 ErrorMessage: edu.harvard.hul.ois.jhove.module.pdf.PdfInvalidException: Invalid indirect destination - 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referenced object 'bm_CR63' cannot be found Offset: 6763541 ID: PDF-HUL-122 ErrorMessage: edu.harvard.hul.ois.jhove.module.pdf.PdfInvalidException: Invalid indirect destination - referenced object 'bm_CR64' cannot be found Offset: 6763541 ID: PDF-HUL-122 ErrorMessage: edu.harvard.hul.ois.jhove.module.pdf.PdfInvalidException: Invalid indirect destination - referenced object 'bm_CR33' cannot be found Offset: 6763541 ID: PDF-HUL-122 ErrorMessage: edu.harvard.hul.ois.jhove.module.pdf.PdfInvalidException: Invalid indirect destination - referenced object 'bm_CR10' cannot be found Offset: 6763541 MIMEtype: application/pdf PDFMetadata: Objects: 759 FreeObjects: 1 IncrementalUpdates: 0 DocumentCatalog: PageLayout: SinglePage PageMode: UseOutlines Language: EN Outlines: Item: Title: Fibroadipogenic progenitors are responsible for muscle loss in limb girdle muscular dystrophy 2B Destination: edu.harvard.hul.ois.jhove.module.pdf.PdfSimpleObject@11758f2a Children: Item: Title: Results Destination: edu.harvard.hul.ois.jhove.module.pdf.PdfSimpleObject@e720b71 Children: Item: Title: Muscle adipogenesis determines LGMD2B onset and severity Destination: edu.harvard.hul.ois.jhove.module.pdf.PdfSimpleObject@1b26f7b2 Item: Title: FAPs cause the adipogenic loss of dysferlinopathic muscle Destination: edu.harvard.hul.ois.jhove.module.pdf.PdfSimpleObject@491cc5c9 Item: Title: Adipogenic muscle loss depends on age and myofiber injury Destination: edu.harvard.hul.ois.jhove.module.pdf.PdfSimpleObject@74ad1f1f Item: Title: AnxA2 links muscle injury to FAP activation and adipogenesis Destination: edu.harvard.hul.ois.jhove.module.pdf.PdfSimpleObject@6a1aab78 Item: Title: Blocking FAP differentiation arrests adipogenic muscle loss Destination: edu.harvard.hul.ois.jhove.module.pdf.PdfSimpleObject@462d5aee Item: Title: Discussion Destination: edu.harvard.hul.ois.jhove.module.pdf.PdfSimpleObject@69b0fd6f Item: Title: Methods Destination: edu.harvard.hul.ois.jhove.module.pdf.PdfSimpleObject@757942a1 Children: Item: Title: Patient biopsies Destination: edu.harvard.hul.ois.jhove.module.pdf.PdfSimpleObject@4a87761d Item: Title: Animals Destination: edu.harvard.hul.ois.jhove.module.pdf.PdfSimpleObject@66d1af89 Item: Title: Immunohistochemical analysis of muscle sections Destination: edu.harvard.hul.ois.jhove.module.pdf.PdfSimpleObject@8646db9 Item: Title: Microscopy and image analysis Destination: edu.harvard.hul.ois.jhove.module.pdf.PdfSimpleObject@37374a5e Item: Title: Isolation and in’vitro adipogenesis of FAPs Destination: edu.harvard.hul.ois.jhove.module.pdf.PdfSimpleObject@4671e53b Item: Title: Notexin injury Destination: edu.harvard.hul.ois.jhove.module.pdf.PdfSimpleObject@2db7a79b Item: Title: Batimastat treatment Destination: edu.harvard.hul.ois.jhove.module.pdf.PdfSimpleObject@6950e31 Item: Title: Statistical analysis Destination: edu.harvard.hul.ois.jhove.module.pdf.PdfSimpleObject@b7dd107 Item: Title: Reporting summary Destination: edu.harvard.hul.ois.jhove.module.pdf.PdfSimpleObject@42eca56e Item: Title: References Destination: edu.harvard.hul.ois.jhove.module.pdf.PdfSimpleObject@52f759d7 Item: Title: References Destination: edu.harvard.hul.ois.jhove.module.pdf.PdfSimpleObject@7cbd213e Item: Title: Acknowledgements Destination: edu.harvard.hul.ois.jhove.module.pdf.PdfSimpleObject@192d3247 Item: Title: Author contributions Destination: edu.harvard.hul.ois.jhove.module.pdf.PdfSimpleObject@3ecd23d9 Item: Title: Competing interests Destination: edu.harvard.hul.ois.jhove.module.pdf.PdfSimpleObject@569cfc36 Item: Title: ACKNOWLEDGEMENTS Destination: edu.harvard.hul.ois.jhove.module.pdf.PdfSimpleObject@43bd930a Info: Title: Fibroadipogenic progenitors are responsible for muscle loss in limb girdle muscular dystrophy 2B Author: Marshall W. 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Hogarth Aurelia Defour Christopher Lazarski Eduard Gallardo Jordi Diaz Manera Terence A. Partridge Kanneboyina Nagaraju Jyoti K. Jaiswal Springer US Nature Communications, doi:10.1038/s41467-019-10438-z 10.1038/s41467-019-10438-z http://dx.doi.org/10.1038/s41467-019-10438-z journal Nature Communications © 2019, The Author(s) 2041-1723 10.1038/s41467-019-10438-z springer.com springerlink.com 2010-04-23 True 10.1038/s41467-019-10438-z springer.com springerlink.com Springer 2019-06-17T16:04:10+02:00 2019-06-14T20:27:03+05:30 2019-06-17T16:04:10+02:00 True iText® 5.3.5 ©2000-2012 1T3XT BVBA (AGPL-version) VoR uuid:c44ffbcf-44f6-4951-bbbb-2ac048775745 uuid:d83bba93-4c73-41b6-beca-2cc9d6f30b5d default 1 converted uuid:6257c69d-f5af-4652-8f11-e0cd930b3d7f converted to PDF/A-2b pdfToolbox 2019-06-14T20:27:52+05:30 2 B Jyoti K. Jaiswal http://orcid.org/0000-0002-5992-5185 http://ns.adobe.com/pdf/1.3/ pdf Adobe PDF Schema internal A name object indicating whether the document has been modified to include trapping information Trapped Text http://ns.adobe.com/pdfx/1.3/ pdfx pdfx internal ID of PDF/X standard GTS_PDFXVersion Text internal Conformance level of PDF/X standard GTS_PDFXConformance Text internal Company creating the PDF Company Text internal Date when document was last modified SourceModified Text external Mirrors crossmark:CrosMarkDomains CrossMarkDomains Seq Text internal Mirrors crossmark:DOI doi Text http://ns.adobe.com/xap/1.0/mm/ xmpMM XMP Media Management Schema internal UUID based identifier for specific incarnation of a document InstanceID URI internal The common identifier for all versions and renditions of a document. OriginalDocumentID URI http://www.aiim.org/pdfa/ns/id/ pdfaid PDF/A ID Schema internal Part of PDF/A standard part Integer internal Amendment of PDF/A standard amd Text internal Conformance level of PDF/A standard conformance Text http://crossref.org/crossmark/1.0/ crossmark crossmark internal CrossMarkDomains CrossMarkDomains Seq Text internal CrossmarkDomainExclusive CrossmarkDomainExclusive Text internal Usual same as prism:doi DOI Text external The date when a publication was published. MajorVersionDate Text http://prismstandard.org/namespaces/basic/2.0/ prism Prism external The aggregation type specifies the unit of aggregation for a content collection. Comment PRISM recommends that the PRISM Aggregation Type Controlled Vocabulary be used to provide values for this element. Note: PRISM recommends against the use of the #other value currently allowed in this controlled vocabulary. In lieu of using #other please reach out to the PRISM group at info@prismstandard.org to request addition of your term to the Aggregation Type Controlled Vocabulary. aggregationType Text external Copyright copyright Text external The Digital Object Identifier for the article. The DOI may also be used as the dc:identifier. If used as a dc:identifier, the URI form should be captured, and the bare identifier should also be captured using prism:doi. If an alternate unique identifier is used as the required dc:identifier, then the DOI should be specified as a bare identifier within prism:doi only. If the URL associated with a DOI is to be specified, then prism:url may be used in conjunction with prism:doi in order to provide the service endpoint (i.e. the URL). doi Text external ISSN for an electronic version of the issue in which the resource occurs. Permits publishers to include a second ISSN, identifying an electronic version of the issue in which the resource occurs (therefore e(lectronic)Issn. If used, prism:eIssn MUST contain the ISSN of the electronic version. See prism:issn. issn Text external Title of the magazine, or other publication, in which a resource was/will be published. Typically this will be used to provide the name of the magazine an article appeared in as metadata for the article, along with information such as the article title, the publisher, volume, number, and cover date. Note: Publication name can be used to differentiate between a print magazine and the online version if the names are different such as “magazine” and “magazine.com.” publicationName Text external This element provides the url for an article or unit of content. The attribute platform is optionally allowed for situations in which multiple URLs must be specified. PRISM recommends that a subset of the PCV platform values, namely “mobile” and “web”, be used in conjunction with this element. NOTE: PRISM recommends against the use of the #other value allowed in the PRISM Platform controlled vocabulary. In lieu of using #other please reach out to the PRISM group at prism-wg@yahoogroups.com to request addition of your term to the Platform Controlled Vocabulary. url Text http://springernature.com/ns/xmpExtensions/2.0/ sn Springer Nature ORCID Schema external Author information: contains the name of each author and his/her ORCID (ORCiD: Open Researcher and Contributor ID). 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