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Title:          LIF regulates CXCL9 in tumor-associated macrophages and prevents CD8+ T cell tumor-infiltration impairing anti-PD1 therapy
Subject:        Nature Communications, doi:10.1038/s41467-019-10369-9
Keywords:       
Author:         Mónica Pascual-García
Creator:        Springer
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      Title: LIF regulates CXCL9 in tumor-associated macrophages and prevents CD8+ T cell tumor-infiltration impairing anti-PD1 therapy
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        Title: Results
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         Item: 
          Title: LIF expression correlates with TAM tumor infiltration
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          Title: The blockade of LIF induces an antitumor immune response
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          Title: LIF regulates the expression of protumoral cytokines in TAMs
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          Title: LIF induces the epigenetic silencing of CXCL9
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          Title: LIF regulates CD8+ T cell tumor infiltration
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          Title: LIF and PD1 blockade promotes tumor regression
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        Title: Methods
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          Title: Patients
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          Title: Human tumoroid and organotypic slice cultures
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          Title: Animals and in’vivo experiments
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          Title: Primary cell cultures and cell lines
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          Title: GBM patient-derived in’vivo models
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         Item: 
          Title: Tumor digestion, flow cytometry, and cell isolation
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         Item: 
          Title: Lentiviral infection
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         Item: 
          Title: CRISPR/LIF cell line generation
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         Item: 
          Title: ELISA
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          Title: Quantitative real-time PCR
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         Item: 
          Title: Immunohistochemical and immunofluorescence staining
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         Item: 
          Title: Microarray expression analysis
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         Item: 
          Title: Chromatin immunoprecipitation assays
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         Item: 
          Title: TCGA data sets analysis
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          Title: Transcriptome analysis of metastatic urothelial carcinoma anti-PD1 treated patients analysis
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          Title: Statistical analysis
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          Title: Reporting summary
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        Title: Acknowledgements
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        Title: Author contributions
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        Title: Competing interests
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        Title: ACKNOWLEDGEMENTS
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