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Title:          Haplotype Analysis of the First A4V-SOD1 Spanish Family: Two Separate Founders or a Single Common Founder?
Subject:        Despite the genetic heterogeneity reported in familial amyotrophic lateral sclerosis (ALS) (fALS), Cu/Zn superoxide-dismutase (SOD1) gene mutations are the second most common cause of the disease, accounting for around 20% of all families (ALS1) and isol
Keywords:       SOD1, A4V, p.A5V, amyotrophic lateral sclerosis, familial amyotrophic lateral sclerosis, ALS1,
founder effect
Author:         Cecilia Garcia
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     Item: 
      Title: Haplotype Analysis of the First 
A4V-SOD1 Spanish Family: Two Separate Founders or a Single Common Founder?
      Children: 
       Item: 
        Title: Introduction
       Item: 
        Title: Material and Methods
        Children: 
         Item: 
          Title: Subjects
         Item: 
          Title: Genetic Studies
          Children: 
           Item: 
            Title: Selection of Single Nucleotide Polymorphisms for Analysis of the SOD1 Haplotype
           Item: 
            Title: Genotyping of Normal and Mutant p.A5V 
Alleles in SOD1
           Item: 
            Title: Genotyping of Single Nucleotide Polymorphisms and Microsatellite
           Item: 
            Title: Analysis of Data
       Item: 
        Title: Results
        Children: 
         Item: 
          Title: Clinical Characteristics of the p.A5V-SOD1 Pedigree
         Item: 
          Title: Genetic Results
         Item: 
          Title: Haplotype Analysis
       Item: 
        Title: Discussion
        Children: 
         Item: 
          Title: Redefining the p.A5V-SOD1 Phenotype. Reasons for the Disease’s Aggressive Course
         Item: 
          Title: Founder Effect
          Children: 
           Item: 
            Title: A Single Origin for All p.A5V-SOD1 
Families Worldwide
           Item: 
            Title: Several Origins (One for Asians, One for Americans, and Perhaps One or More for Europeans)
       Item: 
        Title: Data Availability Statement
       Item: 
        Title: Ethics Statement
       Item: 
        Title: Author Contributions
       Item: 
        Title: Funding
       Item: 
        Title: Acknowledgments
       Item: 
        Title: Supplementary Material
       Item: 
        Title: References
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    Author: Cecilia Garcia
    Subject: Despite the genetic heterogeneity reported in familial amyotrophic lateral sclerosis (ALS) (fALS), Cu/Zn superoxide-dismutase (SOD1) gene mutations are the second most common cause of the disease, accounting for around 20% of all families (ALS1) and isol
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