e677c8eb4652a38853b8bf93b419beea pdf_223420.pdf 9ad2d6ebd908545ccdffe1fc99b2d6d68ce4a92f pdf_223420.pdf e463ff4e36f4b258a70765bbda989ba984449a67afd242693e0bad2844aa4c05 pdf_223420.pdf Title: Recent Advances in the Targeting of Epigenetic Regulators in B-Cell Non-Hodgkin Lymphoma Subject: In the last 10 years, major advances have been made in the diagnosis and development of selective therapies for several blood cancers, including B-cell non-Hodgkin lymphoma (B-NHL), a heterogeneous group of malignancies arising from the mature B lymphocy Keywords: B-cell lymphoma, DNMT, EZH2, HDAC, PRMT inhibitor, BET bromodomain inhibitor (BETi), combination therapy Author: Marcelo L. Ribeiro Creator: Adobe InDesign CC 2015 (Windows) Producer: Adobe PDF Library 15.0 CreationDate: Tue Oct 15 22:25:23 2019 CEST ModDate: Tue Feb 23 16:04:26 2021 CET Tagged: yes UserProperties: no Suspects: no Form: none JavaScript: no Pages: 24 Encrypted: no Page size: 595.276 x 779.528 pts Page rot: 0 File size: 1865546 bytes Optimized: yes PDF version: 1.4 name type encoding emb sub uni object ID ------------------------------------ ----------------- ---------------- --- --- --- --------- HelveticaNeueLTStd-Bd Type 1C Custom yes no yes 3670 0 HelveticaNeueLTStd-BdIt Type 1C WinAnsi yes no yes 3671 0 HelveticaNeueLTStd-LtIt Type 1C Custom yes no yes 3672 0 HelveticaNeueLTStd-MdIt Type 1C WinAnsi yes no yes 3681 0 HelveticaNeueLTStd-Lt Type 1C Custom yes no yes 3682 0 MinionPro-Regular Type 1C Custom yes no yes 3687 0 MinionPro-Bold Type 1C Custom yes no yes 3692 0 MinionPro-It Type 1C Custom yes no yes 215 0 BCXQKW+STIXGeneral Type 1C Custom yes yes yes 222 0 Jhove (Rel. 1.22.1, 2019-04-17) Date: 2021-03-03 02:22:17 CET RepresentationInformation: pdf_223420.pdf ReportingModule: PDF-hul, Rel. 1.12.1 (2019-04-17) LastModified: 2021-02-23 16:04:45 CET Size: 1865546 Format: PDF Version: 1.4 Status: Well-Formed, but not valid SignatureMatches: PDF-hul ErrorMessage: Annotation object is not a dictionary Offset: 4790 MIMEtype: application/pdf Profile: Linearized PDF PDFMetadata: Objects: 3770 FreeObjects: 3380 IncrementalUpdates: 1 DocumentCatalog: ViewerPreferences: HideToolbar: false HideMenubar: false HideWindowUI: false FitWindow: false CenterWindow: false DisplayDocTitle: false NonFullScreenPageMode: UseNone Direction: L2R ViewArea: CropBox ViewClip: CropBox PrintArea: CropBox PageClip: CropBox PageLayout: SinglePage PageMode: UseOutlines Outlines: Item: Title: Recent Advances in the Targeting of Epigenetic Regulators in B-Cell Non-Hodgkin Lymphoma Children: Item: Title: Introduction Children: Item: Title: Characteristics of B-Cell Non-Hodgkin Lymphoma (B-NHL) Item: Title: Altered Chromatin-Modifying Enzymes in B-NHL Item: Title: Targeting Writer Epigenetic Enzymes Children: Item: Title: DNMT Inhibitors Item: Title: EZH2 Inhibitors Item: Title: PRMT Inhibitors Item: Title: Targeting Eraser Epigenetic Enzymes: HDAC Inhibitors Item: Title: Targeting Reader Epigenetic Enzymes Children: Item: Title: BET Inhibitors Item: Title: Non-BET Bromodomain-Containing Proteins: the Histone Acetyltransferase CREB-Binding Protein (CBP) Item: Title: Chromatin Remodelers: SWI/SNF and BRG1 and ARID1 Item: Title: Indirect Inhibition of Epigenetic Dysregulation by IDH Inhibitors Item: Title: Combination Involving Epigenetic-Targeting Approaches Children: Item: Title: Concomitant Targeting of Different Epigenetic Modulators Item: Title: Combination of Epigenetic Drugs With Other Classes of Anti-Tumoral Drugs Item: Title: Conclusions Item: Title: Author Contributions Item: Title: Funding Item: Title: References Info: Title: Recent Advances in the Targeting of Epigenetic Regulators in B-Cell Non-Hodgkin Lymphoma Author: Marcelo L. 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