0a91188cdf9d697bcdd718b17e3529dc 223446.pdf 2982e83129f1e86faaf5ae5a14999c2158b85214 223446.pdf ed152e9b55ec0156e0413f04d1a9cfa368da553620adc239149da64d14d99a3e 223446.pdf Title: Expression of Bone Morphogenetic Proteins in Multiple Sclerosis Lesions Subject: The American Journal of Pathology, 189 (2019) 665-676. doi:10.1016/j.ajpath.2018.11.007 Author: Carme Costa Creator: Elsevier Producer: Acrobat Distiller 8.1.0 (Windows) CreationDate: 21th February 2019 ModDate: Tue Feb 23 16:17:18 2021 CET Tagged: no UserProperties: no Suspects: no Form: none JavaScript: no Pages: 12 Encrypted: no Page size: 584.957 x 782.986 pts Page rot: 0 File size: 9314933 bytes Optimized: yes PDF version: 1.7 name type encoding emb sub uni object ID ------------------------------------ ----------------- ---------------- --- --- --- --------- HMOAGD+AdvOT24cc410c.B Type 1C WinAnsi yes yes no 704 0 HMOAHL+AdvPS44A44B Type 1C WinAnsi yes yes no 706 0 HMOAHM+AdvOT47e7c4c9.I Type 1C WinAnsi yes yes no 708 0 HMOAHN+AdvOT3c2d9f11+fb Type 1C Custom yes yes yes 711 0 HMOAIO+AdvPSSym Type 1C WinAnsi yes yes no 713 0 HMOAGE+AdvOT4a6296b1 Type 1C WinAnsi yes yes no 715 0 HMOAGF+AdvP4C4E74 Type 1C Custom yes yes yes 718 0 HMOAGG+AdvOT21bf1298.I Type 1C WinAnsi yes yes no 720 0 HMOAGH+AdvOT21bf1298.I+20 Type 1C WinAnsi yes yes no 722 0 HMOAGI+AdvOT3c2d9f11 Type 1C WinAnsi yes yes no 724 0 HMOAGJ+AdvOT3c2d9f11+20 Type 1C WinAnsi yes yes no 726 0 HMOAGK+AdvPS3F4C13 Type 1C WinAnsi yes yes no 728 0 HMOAHK+AdvOT4a6296b1+fb Type 1C Custom yes yes yes 730 0 HMOBAM+AdvPSA066 Type 1C WinAnsi yes yes no 466 0 HMOBAN+AdvP4C4E51 Type 1C WinAnsi yes yes no 467 0 HMOBAO+AdvPS480274 Type 1C WinAnsi yes yes no 464 0 HMODMO+AdvPS3FDD77 Type 1C WinAnsi yes yes no 471 0 Jhove (Rel. 1.22.1, 2019-04-17) Date: 2021-12-24 02:25:20 CET RepresentationInformation: 223446.pdf ReportingModule: PDF-hul, Rel. 1.12.1 (2019-04-17) LastModified: 2021-02-23 16:18:08 CET Size: 9314933 Format: PDF Version: 1.7 Status: Well-Formed, but not valid SignatureMatches: PDF-hul ID: PDF-HUL-122 ErrorMessage: edu.harvard.hul.ois.jhove.module.pdf.PdfInvalidException: Invalid indirect destination - referenced object 'bib10' cannot be found Offset: 9306206 ID: PDF-HUL-122 ErrorMessage: edu.harvard.hul.ois.jhove.module.pdf.PdfInvalidException: Invalid indirect destination - referenced object 'bib11' cannot be found Offset: 9306206 ID: PDF-HUL-122 ErrorMessage: edu.harvard.hul.ois.jhove.module.pdf.PdfInvalidException: Invalid indirect destination - referenced object 'bib12' cannot be found Offset: 9306206 ID: PDF-HUL-122 ErrorMessage: edu.harvard.hul.ois.jhove.module.pdf.PdfInvalidException: Invalid indirect destination - referenced object 'bib14' cannot be found Offset: 9306206 ID: PDF-HUL-122 ErrorMessage: edu.harvard.hul.ois.jhove.module.pdf.PdfInvalidException: Invalid indirect destination - referenced object 'bib15' cannot be found Offset: 9306206 ID: PDF-HUL-122 ErrorMessage: edu.harvard.hul.ois.jhove.module.pdf.PdfInvalidException: Invalid indirect destination - referenced object 'bib16' cannot be found Offset: 9306206 ID: PDF-HUL-122 ErrorMessage: edu.harvard.hul.ois.jhove.module.pdf.PdfInvalidException: Invalid indirect destination - referenced object 'bib17' cannot be found Offset: 9306206 ID: PDF-HUL-122 ErrorMessage: edu.harvard.hul.ois.jhove.module.pdf.PdfInvalidException: Invalid indirect destination - referenced object 'bib18' cannot be found Offset: 9306206 ID: PDF-HUL-122 ErrorMessage: edu.harvard.hul.ois.jhove.module.pdf.PdfInvalidException: Invalid indirect destination - referenced object 'bib19' cannot be found Offset: 9306206 ID: PDF-HUL-122 ErrorMessage: edu.harvard.hul.ois.jhove.module.pdf.PdfInvalidException: Invalid indirect destination - referenced object 'appsec1' cannot be found Offset: 9306206 ID: PDF-HUL-122 ErrorMessage: edu.harvard.hul.ois.jhove.module.pdf.PdfInvalidException: Invalid indirect destination - referenced object 'bib20' cannot be found Offset: 9306206 ID: PDF-HUL-122 ErrorMessage: edu.harvard.hul.ois.jhove.module.pdf.PdfInvalidException: Invalid indirect destination - referenced object 'bib26' cannot be found Offset: 9306206 ID: PDF-HUL-122 ErrorMessage: edu.harvard.hul.ois.jhove.module.pdf.PdfInvalidException: Invalid indirect destination - referenced object 'bib20' cannot be found Offset: 9306206 ID: PDF-HUL-122 ErrorMessage: edu.harvard.hul.ois.jhove.module.pdf.PdfInvalidException: Invalid indirect destination - referenced object 'bib28' cannot be found Offset: 9306206 ID: PDF-HUL-122 ErrorMessage: edu.harvard.hul.ois.jhove.module.pdf.PdfInvalidException: Invalid indirect destination - referenced object 'bib29' cannot be found Offset: 9306206 ID: PDF-HUL-122 ErrorMessage: edu.harvard.hul.ois.jhove.module.pdf.PdfInvalidException: Invalid indirect destination - referenced object 'bib20' cannot be found Offset: 9306206 ID: PDF-HUL-122 ErrorMessage: edu.harvard.hul.ois.jhove.module.pdf.PdfInvalidException: Invalid indirect destination - referenced object 'bib21' cannot be found Offset: 9306206 ID: PDF-HUL-122 ErrorMessage: edu.harvard.hul.ois.jhove.module.pdf.PdfInvalidException: Invalid indirect destination - referenced object 'bib31' cannot be found Offset: 9306206 ID: PDF-HUL-122 ErrorMessage: edu.harvard.hul.ois.jhove.module.pdf.PdfInvalidException: Invalid indirect destination - referenced object 'bib15' cannot be found Offset: 9306206 ID: PDF-HUL-122 ErrorMessage: edu.harvard.hul.ois.jhove.module.pdf.PdfInvalidException: Invalid indirect destination - referenced object 'bib14' cannot be found Offset: 9306206 ID: PDF-HUL-122 ErrorMessage: edu.harvard.hul.ois.jhove.module.pdf.PdfInvalidException: Invalid indirect destination - referenced object 'bib32' cannot be found Offset: 9306206 ID: PDF-HUL-122 ErrorMessage: edu.harvard.hul.ois.jhove.module.pdf.PdfInvalidException: Invalid indirect destination - referenced object 'bib15' cannot be found Offset: 9306206 ID: PDF-HUL-122 ErrorMessage: edu.harvard.hul.ois.jhove.module.pdf.PdfInvalidException: Invalid indirect destination - referenced object 'bib14' cannot be found Offset: 9306206 ID: PDF-HUL-122 ErrorMessage: edu.harvard.hul.ois.jhove.module.pdf.PdfInvalidException: Invalid indirect destination - referenced object 'bib15' cannot be found Offset: 9306206 ID: PDF-HUL-122 ErrorMessage: edu.harvard.hul.ois.jhove.module.pdf.PdfInvalidException: Invalid indirect destination - referenced object 'bib34' cannot be found Offset: 9306206 ID: PDF-HUL-122 ErrorMessage: edu.harvard.hul.ois.jhove.module.pdf.PdfInvalidException: Invalid indirect destination - referenced object 'bib15' cannot be found Offset: 9306206 ID: PDF-HUL-128 InfoMessage: Outlines contain recursive references. MIMEtype: application/pdf Profile: Linearized PDF PDFMetadata: Objects: 0 FreeObjects: 1 IncrementalUpdates: 0 DocumentCatalog: PageLayout: SinglePage PageMode: UseOutlines Outlines: Item: Title: Expression of Bone Morphogenetic Proteins in Multiple Sclerosis Lesions Children: Item: Title: Materials and Methods Destination: edu.harvard.hul.ois.jhove.module.pdf.PdfSimpleObject@757942a1 Children: Item: Title: Tissue Samples Destination: edu.harvard.hul.ois.jhove.module.pdf.PdfSimpleObject@4a87761d Item: Title: Histopathological Characterization of Demyelinated Lesions and Classification of MS Lesions Destination: edu.harvard.hul.ois.jhove.module.pdf.PdfSimpleObject@66d1af89 Item: Title: Immunohistochemistry Destination: edu.harvard.hul.ois.jhove.module.pdf.PdfSimpleObject@8646db9 Item: Title: Immunostaining Assessment Destination: edu.harvard.hul.ois.jhove.module.pdf.PdfSimpleObject@37374a5e Item: Title: Statistical Analysis Destination: edu.harvard.hul.ois.jhove.module.pdf.PdfSimpleObject@4671e53b Item: Title: Results Destination: edu.harvard.hul.ois.jhove.module.pdf.PdfSimpleObject@2db7a79b Children: Item: Title: BMPs, BMPRII, and pSMAD1/5/8 Are Expressed in Different Cell Types in MS Lesions Destination: edu.harvard.hul.ois.jhove.module.pdf.PdfSimpleObject@6950e31 Item: Title: Higher Expression of BMPs, BMPRII, and pSMAD1/5/8 in MS Lesions with High Inflammatory Activity Destination: edu.harvard.hul.ois.jhove.module.pdf.PdfSimpleObject@b7dd107 Item: Title: Expression of BMPs, BMPRII, and pSMAD1/5/8 in Lesions of Other White Matter–Damaging Diseases Destination: edu.harvard.hul.ois.jhove.module.pdf.PdfSimpleObject@42eca56e Children: Item: Title: Expression Pattern of BMP-2, BMP-4, BMP-5, BMP-7, BMPRII, and pSMAD1/5/8 in NNC, AI, and PML Lesions Destination: edu.harvard.hul.ois.jhove.module.pdf.PdfSimpleObject@52f759d7 Item: Title: Higher Expression of BMPs, BMPRII, and pSMAD1/5/8 in MS Lesions with High Inflammatory Activity Destination: edu.harvard.hul.ois.jhove.module.pdf.PdfSimpleObject@7cbd213e Item: Title: Discussion Destination: edu.harvard.hul.ois.jhove.module.pdf.PdfSimpleObject@192d3247 Item: Title: Supplemental Data Destination: edu.harvard.hul.ois.jhove.module.pdf.PdfSimpleObject@3ecd23d9 Item: Title: References Destination: edu.harvard.hul.ois.jhove.module.pdf.PdfSimpleObject@569cfc36 Filters: FilterPipeline: FlateDecode FilterPipeline: DCTDecode Images: Image: NisoImageMetadata: FormatName: image/jpg CompressionScheme: JPEG ImageWidth: 1350 ImageHeight: 2003 ColorSpace: RGB BitsPerSample: 8 BitsPerSampleUnit: integer Image: NisoImageMetadata: FormatName: image/jpg CompressionScheme: JPEG ImageWidth: 2002 ImageHeight: 2691 ColorSpace: RGB BitsPerSample: 8 BitsPerSampleUnit: integer Image: NisoImageMetadata: FormatName: image/jpg CompressionScheme: JPEG ImageWidth: 1993 ImageHeight: 2618 ColorSpace: RGB BitsPerSample: 8 BitsPerSampleUnit: integer Image: NisoImageMetadata: FormatName: image/jpg CompressionScheme: JPEG ImageWidth: 950 ImageHeight: 2421 ColorSpace: black is zero BitsPerSample: 8 BitsPerSampleUnit: integer Image: NisoImageMetadata: FormatName: image/jpg CompressionScheme: JPEG ImageWidth: 2001 ImageHeight: 1586 ColorSpace: RGB BitsPerSample: 8 BitsPerSampleUnit: integer Fonts: Type1: Font: BaseFont: HMOAGD+AdvOT24cc410c.B FontSubset: true FirstChar: 44 LastChar: 121 FontDescriptor: FontName: HMOAGD+AdvOT24cc410c.B Flags: Nonsymbolic FontBBox: -31, -260, 906, 958 FontFile3: true Encoding: WinAnsiEncoding Font: BaseFont: HMOAHL+AdvPS44A44B FontSubset: true FirstChar: 101 LastChar: 101 FontDescriptor: FontName: HMOAHL+AdvPS44A44B Flags: Nonsymbolic FontBBox: 0, -197, 1000, 802 FontFile3: true Encoding: WinAnsiEncoding Font: BaseFont: HMOAHM+AdvOT47e7c4c9.I FontSubset: true FirstChar: 40 LastChar: 116 FontDescriptor: FontName: HMOAHM+AdvOT47e7c4c9.I Flags: Nonsymbolic FontBBox: -156, -250, 875, 916 FontFile3: true Encoding: WinAnsiEncoding Font: BaseFont: HMOAHN+AdvOT3c2d9f11+fb FontSubset: true FirstChar: 1 LastChar: 3 FontDescriptor: FontName: HMOAHN+AdvOT3c2d9f11+fb Flags: Symbolic FontBBox: 19, 0, 520, 677 FontFile3: true EncodingDictionary: Differences: true ToUnicode: true Font: BaseFont: HMOAIO+AdvPSSym FontSubset: true FirstChar: 170 LastChar: 170 FontDescriptor: FontName: HMOAIO+AdvPSSym Flags: Nonsymbolic FontBBox: -177, -291, 1083, 1010 FontFile3: true Encoding: WinAnsiEncoding Font: BaseFont: HMOAGE+AdvOT4a6296b1 FontSubset: true FirstChar: 40 LastChar: 243 FontDescriptor: FontName: HMOAGE+AdvOT4a6296b1 Flags: Nonsymbolic FontBBox: -72, -250, 875, 916 FontFile3: true Encoding: WinAnsiEncoding Font: BaseFont: HMOAGF+AdvP4C4E74 FontSubset: true FirstChar: 2 LastChar: 254 FontDescriptor: FontName: HMOAGF+AdvP4C4E74 Flags: Symbolic FontBBox: -20, -958, 1114, 770 FontFile3: true EncodingDictionary: Differences: true ToUnicode: true Font: BaseFont: HMOAGG+AdvOT21bf1298.I FontSubset: true FirstChar: 40 LastChar: 121 FontDescriptor: FontName: HMOAGG+AdvOT21bf1298.I Flags: Serif, Nonsymbolic FontBBox: -166, -208, 906, 875 FontFile3: true Encoding: WinAnsiEncoding Font: BaseFont: HMOBAO+AdvPS480274 FontSubset: true FirstChar: 45 LastChar: 45 FontDescriptor: FontName: HMOBAO+AdvPS480274 Flags: Nonsymbolic FontBBox: 0, -208, 1354, 791 FontFile3: true Encoding: WinAnsiEncoding Font: BaseFont: HMOAGH+AdvOT21bf1298.I+20 FontSubset: true FirstChar: 146 LastChar: 146 FontDescriptor: FontName: HMOAGH+AdvOT21bf1298.I+20 Flags: Nonsymbolic FontBBox: -166, -156, 1000, 697 FontFile3: true Encoding: WinAnsiEncoding Font: BaseFont: HMOBAM+AdvPSA066 FontSubset: true FirstChar: 40 LastChar: 122 FontDescriptor: FontName: HMOBAM+AdvPSA066 Flags: Nonsymbolic FontBBox: -72, -239, 1052, 750 FontFile3: true Encoding: WinAnsiEncoding Font: BaseFont: HMOBAN+AdvP4C4E51 FontSubset: true FirstChar: 60 LastChar: 60 FontDescriptor: FontName: HMOBAN+AdvP4C4E51 Flags: Nonsymbolic FontBBox: -31, -239, 1041, 750 FontFile3: true Encoding: WinAnsiEncoding Font: BaseFont: HMOAGI+AdvOT3c2d9f11 FontSubset: true FirstChar: 37 LastChar: 252 FontDescriptor: FontName: HMOAGI+AdvOT3c2d9f11 Flags: Serif, Nonsymbolic FontBBox: -62, -208, 927, 895 FontFile3: true Encoding: WinAnsiEncoding Font: BaseFont: HMOAGJ+AdvOT3c2d9f11+20 FontSubset: true FirstChar: 146 LastChar: 146 FontDescriptor: FontName: HMOAGJ+AdvOT3c2d9f11+20 Flags: Nonsymbolic FontBBox: -166, -145, 1000, 697 FontFile3: true Encoding: WinAnsiEncoding Font: BaseFont: HMODMO+AdvPS3FDD77 FontSubset: true FirstChar: 90 LastChar: 90 FontDescriptor: FontName: HMODMO+AdvPS3FDD77 Flags: Nonsymbolic FontBBox: 0, -208, 1145, 864 FontFile3: true Encoding: WinAnsiEncoding Font: BaseFont: HMOAGK+AdvPS3F4C13 FontSubset: true FirstChar: 98 LastChar: 109 FontDescriptor: FontName: HMOAGK+AdvPS3F4C13 Flags: Nonsymbolic FontBBox: 0, -291, 875, 697 FontFile3: true Encoding: WinAnsiEncoding Font: BaseFont: HMOAHK+AdvOT4a6296b1+fb FontSubset: true FirstChar: 1 LastChar: 3 FontDescriptor: FontName: HMOAHK+AdvOT4a6296b1+fb Flags: Symbolic FontBBox: 19, -10, 562, 718 FontFile3: true EncodingDictionary: Differences: true ToUnicode: true XMP: application/pdf doi:10.1016/j.ajpath.2018.11.007 Expression of Bone Morphogenetic Proteins in Multiple Sclerosis Lesions Carme Costa Herena Eixarch Elena Martínez-Sáez Laura Calvo-Barreiro Maite Calucho Zoraida Castro Arantxa Ortega-Aznar Santiago Ramón y Cajal Xavier Montalban Carmen Espejo The American Journal of Pathology, 189 (2019) 665-676. doi:10.1016/j.ajpath.2018.11.007 American Society for Investigative Pathology journal The American Journal of Pathology © 2019 American Society for Investigative Pathology. Published by Elsevier Inc. 0002-9440 189 3 March 2019 665-676 665 676 10.1016/j.ajpath.2018.11.007 https://doi.org/10.1016/j.ajpath.2018.11.007 2010-04-23 true 10.1016/j.ajpath.2018.11.007 elsevier.com sciencedirect.com VoR 6.5 10.1016/j.ajpath.2018.11.007 noindex 2010-04-23 true 21th February 2019 sciencedirect.com elsevier.com Elsevier 2021-02-23T16:17:18+01:00 2021-02-23T16:17:18+01:00 True 21th February 2019 Acrobat Distiller 8.1.0 (Windows) uuid:0fe0a872-ab4f-4438-bbd9-182c680e1c6b uuid:04b36315-226e-4bc4-a361-7dcb941190b0 http://creativecommons.org/licenses/by-nc-nd/4.0/ Pages: Page: Label: 665 Sequence: 1 Annotations: Annotation: Subtype: Link Rect: 44, 549, 44, 551 Annotation: Subtype: Link Rect: 108, 549, 108, 551 Annotation: Subtype: Link Rect: 182, 549, 182, 551 Annotation: Subtype: Link Rect: 275, 549, 275, 551 Annotation: Subtype: Link Rect: 370, 549, 370, 551 Annotation: Subtype: Link Rect: 441, 549, 441, 551 Annotation: Subtype: Link Rect: 44, 538, 44, 540 Annotation: Subtype: Link Rect: 143, 538, 143, 540 Annotation: Subtype: Link Rect: 251, 538, 251, 540 Annotation: Subtype: Link Rect: 356, 538, 356, 540 Annotation: Subtype: Link Rect: 47, 317, 125, 325 Annotation: Subtype: Link Rect: 311, 278, 477, 287 Annotation: Subtype: Link Rect: 133, 192, 137, 202 Destination: 33 Annotation: Subtype: Link Rect: 148, 168, 152, 178 Destination: 33 Annotation: Subtype: Link Rect: 212, 132, 215, 142 Destination: 33 Annotation: Subtype: Link Rect: 255, 108, 259, 118 Destination: 33 Annotation: Subtype: Link Rect: 117, 84, 121, 94 Destination: 33 Annotation: Subtype: Link Rect: 537, 204, 546, 214 Destination: 33 Annotation: Subtype: Link Rect: 468, 596, 546, 611 Annotation: Subtype: Link Rect: 230, 29, 368, 36 Annotation: Subtype: Link Rect: 44, 19, 167, 26 Annotation: Subtype: Link Rect: 476, 665, 533, 673 Annotation: Subtype: Link Rect: 44, 741, 254, 749 Page: Label: 666 Sequence: 2 Annotations: Annotation: Subtype: Link Rect: 62, 552, 66, 562 Destination: 33 Annotation: Subtype: Link Rect: 181, 492, 185, 502 Destination: 33 Annotation: Subtype: Link Rect: 120, 421, 127, 431 Destination: null Annotation: Subtype: Link Rect: 532, 564, 539, 574 Destination: null Annotation: Subtype: Link Rect: 492, 540, 509, 550 Destination: null Annotation: Subtype: Link Rect: 432, 504, 439, 514 Destination: null Annotation: Subtype: Link Rect: 437, 480, 444, 490 Destination: null Annotation: Subtype: Link Rect: 310, 18, 382, 28 Page: Label: 667 Sequence: 3 Annotations: Annotation: Subtype: Link Rect: 108, 205, 116, 215 Destination: null Annotation: Subtype: Link Rect: 344, 176, 375, 186 Destination: 1 Annotation: Subtype: Link Rect: 202, 18, 273, 28 Page: Label: 668 Sequence: 4 Annotations: Annotation: Subtype: Link Rect: 310, 18, 382, 28 Page: Label: 669 Sequence: 5 Annotations: Annotation: Subtype: Link Rect: 78, 600, 86, 610 Destination: null Annotation: Subtype: Link Rect: 48, 232, 80, 242 Destination: 1 Annotation: Subtype: Link Rect: 158, 196, 188, 206 Destination: 1 Annotation: Subtype: Link Rect: 249, 184, 280, 194 Destination: 1 Annotation: Subtype: Link Rect: 404, 583, 436, 593 Destination: 1 Annotation: Subtype: Link Rect: 479, 571, 509, 581 Destination: 1 Annotation: Subtype: Link Rect: 359, 547, 388, 557 Destination: 1 Annotation: Subtype: Link Rect: 370, 189, 377, 199 Destination: null Annotation: Subtype: Link Rect: 362, 177, 370, 187 Destination: null Annotation: Subtype: Link Rect: 202, 18, 273, 28 Page: Label: 670 Sequence: 6 Annotations: Annotation: Subtype: Link Rect: 310, 18, 382, 28 Page: Label: 671 Sequence: 7 Annotations: Annotation: Subtype: Link Rect: 191, 599, 225, 608 Destination: 4 Annotation: Subtype: Link Rect: 48, 551, 81, 561 Destination: 4 Annotation: Subtype: Link Rect: 123, 527, 157, 537 Destination: 4 Annotation: Subtype: Link Rect: 86, 515, 190, 525 Destination: null Annotation: Subtype: Link Rect: 163, 388, 257, 398 Destination: 4 Annotation: Subtype: Link Rect: 144, 269, 178, 279 Destination: 8 Annotation: Subtype: Link Rect: 134, 233, 169, 243 Destination: 15 Annotation: Subtype: Link Rect: 311, 607, 349, 617 Destination: 22 Annotation: Subtype: Link Rect: 379, 607, 384, 617 Destination: 26 Annotation: Subtype: Link Rect: 311, 475, 350, 485 Destination: 22 Annotation: Subtype: Link Rect: 382, 475, 387, 485 Destination: 26 Annotation: Subtype: Link Rect: 498, 368, 534, 378 Destination: 22 Annotation: Subtype: Link Rect: 202, 18, 273, 28 Page: Label: 672 Sequence: 8 Annotations: Annotation: Subtype: Link Rect: 496, 679, 530, 689 Destination: 8 Annotation: Subtype: Link Rect: 402, 631, 436, 641 Destination: 15 Annotation: Subtype: Link Rect: 464, 428, 502, 438 Destination: 22 Annotation: Subtype: Link Rect: 529, 428, 534, 438 Destination: 26 Annotation: Subtype: Link Rect: 358, 309, 395, 319 Destination: 22 Annotation: Subtype: Link Rect: 310, 18, 382, 28 Page: Label: 673 Sequence: 9 Annotations: Annotation: Subtype: Link Rect: 48, 176, 86, 186 Destination: 22 Annotation: Subtype: Link Rect: 114, 176, 119, 186 Destination: 26 Annotation: Subtype: Link Rect: 48, 128, 83, 138 Destination: 22 Annotation: Subtype: Link Rect: 237, 57, 271, 67 Destination: 22 Annotation: Subtype: Link Rect: 414, 200, 448, 210 Destination: 22 Annotation: Subtype: Link Rect: 482, 93, 516, 103 Destination: 22 Annotation: Subtype: Link Rect: 202, 18, 273, 28 Page: Label: 674 Sequence: 10 Annotations: Annotation: Subtype: Link Rect: 81, 575, 98, 585 Destination: null Annotation: Subtype: Link Rect: 78, 563, 101, 573 Destination: 33 Annotation: Subtype: Link Rect: 112, 551, 135, 561 Destination: 33 Annotation: Subtype: Link Rect: 206, 480, 223, 490 Destination: null Annotation: Subtype: Link Rect: 156, 252, 173, 262 Destination: null Annotation: Subtype: Link Rect: 252, 145, 259, 155 Destination: null Annotation: Subtype: Link Rect: 192, 97, 200, 107 Destination: null Annotation: Subtype: Link Rect: 354, 552, 362, 561 Destination: null Annotation: Subtype: Link Rect: 378, 456, 401, 466 Destination: 33 Annotation: Subtype: Link Rect: 346, 360, 354, 370 Destination: null Annotation: Subtype: Link Rect: 353, 312, 360, 322 Destination: null Annotation: Subtype: Link Rect: 377, 265, 385, 275 Destination: null Annotation: Subtype: Link Rect: 469, 229, 476, 239 Destination: null Annotation: Subtype: Link Rect: 422, 205, 430, 215 Destination: null Annotation: Subtype: Link Rect: 324, 181, 332, 191 Destination: null Annotation: Subtype: Link Rect: 418, 169, 422, 179 Destination: 33 Annotation: Subtype: Link Rect: 536, 145, 539, 155 Destination: 33 Annotation: Subtype: Link Rect: 424, 109, 441, 119 Destination: null Annotation: Subtype: Link Rect: 517, 85, 524, 95 Destination: null Annotation: Subtype: Link Rect: 310, 18, 382, 28 Page: Label: 675 Sequence: 11 Annotations: Annotation: Subtype: Link Rect: 173, 611, 181, 621 Destination: null Annotation: Subtype: Link Rect: 236, 528, 239, 538 Destination: 33 Annotation: Subtype: Link Rect: 192, 516, 200, 526 Destination: null Annotation: Subtype: Link Rect: 44, 263, 222, 273 Annotation: Subtype: Link Rect: 59, 208, 283, 216 Annotation: Subtype: Link Rect: 59, 198, 137, 206 Annotation: Subtype: Link Rect: 143, 198, 151, 206 Annotation: Subtype: Link Rect: 59, 188, 283, 196 Annotation: Subtype: Link Rect: 59, 178, 283, 186 Annotation: Subtype: Link Rect: 59, 168, 242, 176 Annotation: Subtype: Link Rect: 248, 168, 264, 176 Annotation: Subtype: Link Rect: 59, 158, 283, 166 Annotation: Subtype: Link Rect: 59, 148, 283, 156 Annotation: Subtype: Link Rect: 59, 138, 283, 146 Annotation: Subtype: Link Rect: 59, 128, 147, 136 Annotation: Subtype: Link Rect: 153, 128, 169, 136 Annotation: Subtype: Link Rect: 59, 118, 283, 126 Annotation: Subtype: Link Rect: 59, 108, 121, 116 Annotation: Subtype: Link Rect: 127, 108, 143, 116 Annotation: Subtype: Link Rect: 59, 98, 283, 106 Annotation: Subtype: Link Rect: 59, 88, 283, 96 Annotation: Subtype: Link Rect: 59, 78, 71, 86 Annotation: Subtype: Link Rect: 77, 78, 89, 86 Annotation: Subtype: Link Rect: 59, 68, 283, 76 Annotation: Subtype: Link Rect: 59, 59, 283, 66 Annotation: Subtype: Link Rect: 322, 716, 546, 724 Annotation: Subtype: Link Rect: 322, 706, 386, 714 Annotation: Subtype: Link Rect: 392, 706, 408, 714 Annotation: Subtype: Link Rect: 322, 696, 546, 704 Annotation: Subtype: Link Rect: 322, 686, 546, 694 Annotation: Subtype: Link Rect: 322, 676, 490, 684 Annotation: Subtype: Link Rect: 496, 676, 504, 684 Annotation: Subtype: Link Rect: 322, 666, 546, 674 Annotation: Subtype: Link Rect: 322, 657, 546, 665 Annotation: Subtype: Link Rect: 322, 647, 452, 655 Annotation: Subtype: Link Rect: 458, 647, 473, 655 Annotation: Subtype: Link Rect: 322, 637, 546, 645 Annotation: Subtype: Link Rect: 322, 627, 546, 635 Annotation: Subtype: Link Rect: 322, 617, 546, 625 Annotation: Subtype: Link Rect: 322, 607, 546, 615 Annotation: Subtype: Link Rect: 322, 597, 484, 605 Annotation: Subtype: Link Rect: 490, 597, 498, 605 Annotation: Subtype: Link Rect: 322, 587, 546, 595 Annotation: Subtype: Link Rect: 322, 577, 396, 585 Annotation: Subtype: Link Rect: 402, 577, 414, 585 Annotation: Subtype: Link Rect: 322, 567, 546, 575 Annotation: Subtype: Link Rect: 322, 557, 546, 565 Annotation: Subtype: Link Rect: 322, 547, 546, 555 Annotation: Subtype: Link Rect: 322, 537, 344, 545 Annotation: Subtype: Link Rect: 350, 537, 362, 545 Annotation: Subtype: Link Rect: 322, 527, 546, 535 Annotation: Subtype: Link Rect: 322, 517, 546, 525 Annotation: Subtype: Link Rect: 322, 507, 440, 515 Annotation: Subtype: Link Rect: 446, 507, 458, 515 Annotation: Subtype: Link Rect: 322, 497, 546, 505 Annotation: Subtype: Link Rect: 322, 487, 546, 495 Annotation: Subtype: Link Rect: 322, 477, 546, 485 Annotation: Subtype: Link Rect: 322, 467, 451, 475 Annotation: Subtype: Link Rect: 457, 467, 473, 475 Annotation: Subtype: Link Rect: 322, 457, 546, 465 Annotation: Subtype: Link Rect: 322, 447, 546, 455 Annotation: Subtype: Link Rect: 322, 437, 479, 445 Annotation: Subtype: Link Rect: 485, 437, 497, 445 Annotation: Subtype: Link Rect: 322, 427, 546, 435 Annotation: Subtype: Link Rect: 322, 417, 546, 425 Annotation: Subtype: Link Rect: 322, 407, 369, 415 Annotation: Subtype: Link Rect: 375, 407, 386, 415 Annotation: Subtype: Link Rect: 322, 397, 546, 405 Annotation: Subtype: Link Rect: 322, 388, 407, 396 Annotation: Subtype: Link Rect: 413, 388, 425, 396 Annotation: Subtype: Link Rect: 322, 378, 546, 386 Annotation: Subtype: Link Rect: 322, 368, 546, 376 Annotation: Subtype: Link Rect: 322, 358, 546, 366 Annotation: Subtype: Link Rect: 322, 348, 449, 356 Annotation: Subtype: Link Rect: 455, 348, 471, 356 Annotation: Subtype: Link Rect: 322, 338, 546, 346 Annotation: Subtype: Link Rect: 322, 328, 487, 336 Annotation: Subtype: Link Rect: 322, 318, 546, 326 Annotation: Subtype: Link Rect: 322, 308, 546, 316 Annotation: Subtype: Link Rect: 322, 298, 412, 306 Annotation: Subtype: Link Rect: 322, 288, 546, 296 Annotation: Subtype: Link Rect: 322, 278, 546, 286 Annotation: Subtype: Link Rect: 322, 268, 546, 276 Annotation: Subtype: Link Rect: 322, 258, 472, 266 Annotation: Subtype: Link Rect: 478, 258, 486, 266 Annotation: Subtype: Link Rect: 322, 248, 546, 256 Annotation: Subtype: Link Rect: 322, 238, 546, 246 Annotation: Subtype: Link Rect: 322, 228, 546, 236 Annotation: Subtype: Link Rect: 322, 218, 436, 226 Annotation: Subtype: Link Rect: 442, 218, 454, 226 Annotation: Subtype: Link Rect: 322, 208, 546, 216 Annotation: Subtype: Link Rect: 322, 198, 546, 206 Annotation: Subtype: Link Rect: 322, 188, 546, 196 Annotation: Subtype: Link Rect: 322, 178, 546, 186 Annotation: Subtype: Link Rect: 322, 168, 365, 176 Annotation: Subtype: Link Rect: 371, 168, 383, 176 Annotation: Subtype: Link Rect: 322, 158, 546, 166 Annotation: Subtype: Link Rect: 322, 148, 546, 156 Annotation: Subtype: Link Rect: 322, 138, 546, 146 Annotation: Subtype: Link Rect: 322, 128, 365, 136 Annotation: Subtype: Link Rect: 371, 128, 383, 136 Annotation: Subtype: Link Rect: 322, 119, 546, 126 Annotation: Subtype: Link Rect: 322, 109, 546, 117 Annotation: Subtype: Link Rect: 322, 99, 365, 107 Annotation: Subtype: Link Rect: 371, 99, 383, 107 Annotation: Subtype: Link Rect: 322, 89, 546, 97 Annotation: Subtype: Link Rect: 322, 79, 546, 87 Annotation: Subtype: Link Rect: 322, 69, 546, 77 Annotation: Subtype: Link Rect: 322, 59, 410, 67 Annotation: Subtype: Link Rect: 416, 59, 428, 67 Annotation: Subtype: Link Rect: 202, 18, 273, 28 Page: Label: 676 Sequence: 12 Annotations: Annotation: Subtype: Link Rect: 52, 716, 276, 724 Annotation: Subtype: Link Rect: 52, 706, 276, 714 Annotation: Subtype: Link Rect: 52, 696, 202, 704 Annotation: Subtype: Link Rect: 208, 696, 216, 704 Annotation: Subtype: Link Rect: 52, 686, 276, 694 Annotation: Subtype: Link Rect: 52, 676, 198, 684 Annotation: Subtype: Link Rect: 204, 676, 216, 684 Annotation: Subtype: Link Rect: 52, 666, 276, 674 Annotation: Subtype: Link Rect: 52, 657, 276, 665 Annotation: Subtype: Link Rect: 52, 647, 188, 655 Annotation: Subtype: Link Rect: 194, 647, 276, 655 Annotation: Subtype: Link Rect: 52, 637, 185, 645 Annotation: Subtype: Link Rect: 52, 627, 276, 635 Annotation: Subtype: Link Rect: 52, 617, 276, 625 Annotation: Subtype: Link Rect: 52, 607, 276, 615 Annotation: Subtype: Link Rect: 52, 597, 126, 605 Annotation: Subtype: Link Rect: 132, 597, 140, 605 Annotation: Subtype: Link Rect: 52, 587, 276, 595 Annotation: Subtype: Link Rect: 52, 577, 276, 585 Annotation: Subtype: Link Rect: 52, 567, 276, 575 Annotation: Subtype: Link Rect: 315, 716, 539, 724 Annotation: Subtype: Link Rect: 315, 706, 452, 714 Annotation: Subtype: Link Rect: 458, 706, 466, 714 Annotation: Subtype: Link Rect: 315, 696, 539, 704 Annotation: Subtype: Link Rect: 315, 686, 478, 694 Annotation: Subtype: Link Rect: 484, 686, 496, 694 Annotation: Subtype: Link Rect: 315, 676, 539, 684 Annotation: Subtype: Link Rect: 315, 666, 539, 674 Annotation: Subtype: Link Rect: 315, 657, 539, 665 Annotation: Subtype: Link Rect: 315, 647, 539, 655 Annotation: Subtype: Link Rect: 315, 637, 522, 645 Annotation: Subtype: Link Rect: 528, 637, 539, 645 Annotation: Subtype: Link Rect: 315, 627, 539, 635 Annotation: Subtype: Link Rect: 315, 617, 539, 625 Annotation: Subtype: Link Rect: 315, 607, 539, 615 Annotation: Subtype: Link Rect: 315, 597, 331, 605 Annotation: Subtype: Link Rect: 337, 597, 353, 605 Annotation: Subtype: Link Rect: 315, 587, 539, 595 Annotation: Subtype: Link Rect: 315, 577, 539, 585 Annotation: Subtype: Link Rect: 315, 567, 511, 575 Annotation: Subtype: Link Rect: 517, 567, 529, 575 Annotation: Subtype: Link Rect: 310, 18, 382, 28 Checksum: 37409ef3 Type: CRC32 Checksum: 0a91188cdf9d697bcdd718b17e3529dc Type: MD5 Checksum: 2982e83129f1e86faaf5ae5a14999c2158b85214 Type: SHA-1