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Title:          CIBER-CLAP (CIBERCV Cardioprotection Large Animal Platform): A multicenter preclinical network for testing reproducibility in cardiovascular interventions
Subject:        Scientific Reports, doi:10.1038/s41598-019-56613-6
Keywords:       
Author:         Xavier Rossello
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Table 1. Rationale for using local IPC in CIBER-CLAP. AMI, acute myocardial infarction; IPC; ischemic preconditioning; IRI, ischemia/reperfusion injury; RISK, Reperfusion Injury Salvage Kinase; SAFE. Survivor Activator Factor Enhanc:92' cannot be found
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Table 2. Outcomes to be assessed by sets of experiments. In bold, the primary endpoint for each subset of experiments. AAR, area at risk; CMR, cardiac magnetic resonance; LV, left ventricular.:114' cannot be found
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Table 2. Outcomes to be assessed by sets of experiments. In bold, the primary endpoint for each subset of experiments. AAR, area at risk; CMR, cardiac magnetic resonance; LV, left ventricular.:127' cannot be found
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      Title: CIBER-CLAP (CIBERCV Cardioprotection Large Animal Platform): A multicenter preclinical network for testing reproducibility  ...
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        Title: Cardioprotection: Reasons for Loss in Translation
        Children: 
         Item: 
          Title: Previous attempts to assess variability across laboratories. 
         Item: 
          Title: The CIBER-CLAP platform. 
         Item: 
          Title: Rationale for using local ischemic preconditioning (IPC). 
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        Title: Study Design
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         Item: 
          Title: Study hypothesis and end points. 
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          Title: Parallel subsets of experiments. 
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           Item: 
            Title: Pig model of acute myocardial infarction. 
           Item: 
            Title: Intervention. 
           Item: 
            Title: Plasma collection. 
           Item: 
            Title: CMR protocol. 
           Item: 
            Title: CMR data analysis. 
           Item: 
            Title: Histopathology assessment. 
           Item: 
            Title: Western blot analysis. 
           Item: 
            Title: Proteomics. 
         Item: 
          Title: Randomization. 
         Item: 
          Title: Data management and logistics. 
         Item: 
          Title: Sample size. 
         Item: 
          Title: Statistical analysis plan. 
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          Title: Potential impact of the findings: CIBER-CLAP. 
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          Title: Limitations. 
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        Title: Acknowledgements
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        Title: Table 1 Rationale for using local IPC in CIBER-CLAP.
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PRISM recommends that the PRISM Aggregation Type Controlled Vocabulary be used to provide values for this element. 
Note: PRISM recommends against the use of the #other value currently allowed in this controlled vocabulary. In lieu of using #other please reach out to the PRISM group at info@prismstandard.org to request addition of your term to the Aggregation Type Controlled Vocabulary. 

</pdfaProperty:description>
                           <pdfaProperty:name>aggregationType</pdfaProperty:name>
                           <pdfaProperty:valueType>Text</pdfaProperty:valueType>
                        </rdf:li>
                        <rdf:li rdf:parseType="Resource">
                           <pdfaProperty:category>external</pdfaProperty:category>
                           <pdfaProperty:description>Copyright </pdfaProperty:description>
                           <pdfaProperty:name>copyright</pdfaProperty:name>
                           <pdfaProperty:valueType>Text</pdfaProperty:valueType>
                        </rdf:li>
                        <rdf:li rdf:parseType="Resource">
                           <pdfaProperty:category>external</pdfaProperty:category>
                           <pdfaProperty:description>The Digital Object Identifier for the article.
The DOI may also be used as the dc:identifier. If used as a dc:identifier, the URI form should be captured, and the bare identifier should also be captured using prism:doi. If an alternate unique identifier is used as the required dc:identifier, then the DOI should be specified as a bare identifier within prism:doi only. 
If the URL associated with a DOI is to be specified, then prism:url may be used in conjunction with prism:doi in order to provide the service endpoint (i.e. the URL). 
</pdfaProperty:description>
                           <pdfaProperty:name>doi</pdfaProperty:name>
                           <pdfaProperty:valueType>Text</pdfaProperty:valueType>
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                        <rdf:li rdf:parseType="Resource">
                           <pdfaProperty:category>external</pdfaProperty:category>
                           <pdfaProperty:description>ISSN for an electronic version of the issue in which the resource occurs. 
Permits publishers to include a second ISSN, identifying an electronic version of the issue in which the resource occurs (therefore e(lectronic)Issn. If used, prism:eIssn MUST contain the ISSN of the electronic version. See prism:issn. 
</pdfaProperty:description>
                           <pdfaProperty:name>issn</pdfaProperty:name>
                           <pdfaProperty:valueType>Text</pdfaProperty:valueType>
                        </rdf:li>
                        <rdf:li rdf:parseType="Resource">
                           <pdfaProperty:category>external</pdfaProperty:category>
                           <pdfaProperty:description>Title of the magazine, or other publication, in which a resource was/will be published. 
Typically this will be used to provide the name of the magazine an article appeared in as metadata for the article, along with information such as the article title, the publisher, volume, number, and cover date. 

Note: Publication name can be used to differentiate between a print magazine and the online version if the names are different such as “magazine” and “magazine.com.” 
</pdfaProperty:description>
                           <pdfaProperty:name>publicationName</pdfaProperty:name>
                           <pdfaProperty:valueType>Text</pdfaProperty:valueType>
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                        <rdf:li rdf:parseType="Resource">
                           <pdfaProperty:category>external</pdfaProperty:category>
                           <pdfaProperty:description>This element provides the url for an article or unit of content. 
The attribute platform is optionally allowed for situations in which multiple URLs must be specified. PRISM recommends that a subset of the PCV platform values, namely “mobile” and “web”, be used in conjunction with this element. 
NOTE: PRISM recommends against the use of the #other value allowed in the PRISM Platform controlled vocabulary. In lieu of using #other please reach out to the PRISM group at prism-wg@yahoogroups.com to request addition of your term to the Platform Controlled Vocabulary. 
</pdfaProperty:description>
                           <pdfaProperty:name>url</pdfaProperty:name>
                           <pdfaProperty:valueType>Text</pdfaProperty:valueType>
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                  <pdfaSchema:namespaceURI>http://www.niso.org/schemas/jav/1.0/</pdfaSchema:namespaceURI>
                  <pdfaSchema:prefix>jav</pdfaSchema:prefix>
                  <pdfaSchema:schema>NISO</pdfaSchema:schema>
                  <pdfaSchema:property>
                     <rdf:Seq>
                        <rdf:li rdf:parseType="Resource">
                           <pdfaProperty:category>external</pdfaProperty:category>
                           <pdfaProperty:description>Values for Journal Article Version are one of the following:
AO = Author’s Original
SMUR = Submitted Manuscript Under Review
AM = Accepted Manuscript
P = Proof
VoR = Version of Record
CVoR = Corrected Version of Record
EVoR = Enhanced Version of Record</pdfaProperty:description>
                           <pdfaProperty:name>journal_article_version</pdfaProperty:name>
                           <pdfaProperty:valueType>Closed Choice of Text</pdfaProperty:valueType>
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       Rect: 344, 442, 504, 430
       Flags: Print
       AppearanceDictionary: true
     Thumb: true
  Checksum: fdffd67a
   Type: CRC32
  Checksum: c0f872a3760516307132c27df12dcd8c
   Type: MD5
  Checksum: c773a0114e20c1cb8a94186c9a285d0d307af837
   Type: SHA-1