e9f715db0a7648b3683ebc2cbee762c2 223617.pdf 49b49bf477bd4967bcb1c2341a97084c2329c93f 223617.pdf 37eecb5840703359b97eac2d785a0ba5316a7d9a2eba2ed549d05538a37e8dc4 223617.pdf Title: Manipulation of Gut Microbiota Influences Immune Responses, Axon Preservation, and Motor Disability in a Model of Progressive Multiple Sclerosis Subject: Gut microbiota dysbiosis has been implicated in MS and other immune diseases, although it remains unclear how manipulating the gut microbiota may affect the disease course. Keywords: Theiler's virus model, gut microbiota, Treg and Breg cells, neuroinflammation, multiple sclerosis Author: Leyre Mestre and Carmen Guaza Creator: LaTeX with hyperref package + hypdvips Producer: dvips + MiKTeX GPL Ghostscript 9.0 CreationDate: Fri Jun 14 09:18:48 2019 CEST ModDate: Wed Jul 21 12:42:52 2021 CEST Tagged: no UserProperties: no Suspects: no Form: none JavaScript: no Pages: 18 Encrypted: no Page size: 595.26 x 779.52 pts Page rot: 0 File size: 3141956 bytes Optimized: yes PDF version: 1.4 name type encoding emb sub uni object ID ------------------------------------ ----------------- ---------------- --- --- --- --------- AKHODU+HelveticaNeueLTStd-Bd Type 1C Custom yes yes no 412 0 ETZYHP+HelveticaNeueLTStd-Lt Type 1C Custom yes yes no 416 0 WHQTYR+HelveticaNeueLTStd-BdIt Type 1C WinAnsi yes yes no 421 0 ODNJIL+HelveticaNeueLTStd-LtIt Type 1C Custom yes yes no 425 0 GIBCHK+HelveticaNeueLTStd-MdIt Type 1C WinAnsi yes yes no 429 0 ABMTGG+MTSY Type 1C Custom yes yes 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SinglePage PageMode: UseOutlines Language: en Outlines: Item: Title: Manipulation of Gut Microbiota Influences Immune Responses, Axon Preservation, and Motor Disability in a Model of Progressive 䴀甀氀琀椀瀀氀攀 匀挀氀攀爀漀猀椀猩㸾൥湤潢樍㐴㠠〠潢樍㰼⽁捴楯港䝯呯⽄敳琯獥捴楯渪⸲⽎數琠㐶〠〠刯偡牥湴‴㐷‰⁒⽔楴汥⣾＀䤀渀琀爀漀搀甀挀琀椀漀温㸾൥湤潢樍㐴㤠〠潢樍㰼⽁捴楯港䝯呯⽄敳琯獥捴楯渪⸳〯偡牥湴‴㐷‰⁒⽐牥瘠㐵〠〠刯呩瑬攨References Destination: edu.harvard.hul.ois.jhove.module.pdf.PdfSimpleObject@4eb7f003 Children: Item: Title: Introduction Destination: edu.harvard.hul.ois.jhove.module.pdf.PdfSimpleObject@eafc191 Item: Title: Materials and Methods Destination: edu.harvard.hul.ois.jhove.module.pdf.PdfSimpleObject@612fc6eb Children: Item: Title: Animals and TMEV Infection Destination: edu.harvard.hul.ois.jhove.module.pdf.PdfSimpleObject@1060b431 Item: Title: Treatments Destination: edu.harvard.hul.ois.jhove.module.pdf.PdfSimpleObject@612679d6 Item: Title: Evaluation of Motor Function Destination: edu.harvard.hul.ois.jhove.module.pdf.PdfSimpleObject@11758f2a Item: Title: Sample Collection Destination: edu.harvard.hul.ois.jhove.module.pdf.PdfSimpleObject@e720b71 Item: Title: Metabolite Analysis Destination: edu.harvard.hul.ois.jhove.module.pdf.PdfSimpleObject@1b26f7b2 Item: Title: CD4T Cells ex vivo Experiments Destination: edu.harvard.hul.ois.jhove.module.pdf.PdfSimpleObject@491cc5c9 Item: Title: ELISA Destination: edu.harvard.hul.ois.jhove.module.pdf.PdfSimpleObject@74ad1f1f Item: Title: Tissue Processing and Immunohistochemistry Destination: edu.harvard.hul.ois.jhove.module.pdf.PdfSimpleObject@6a1aab78 Item: Title: RNA Extraction, Reverse Transcription, and RT-PCR Destination: edu.harvard.hul.ois.jhove.module.pdf.PdfSimpleObject@462d5aee Item: Title: Flow Cytometry Destination: edu.harvard.hul.ois.jhove.module.pdf.PdfSimpleObject@69b0fd6f Item: Title: 16S rRNA Microbial Community Analysis Destination: edu.harvard.hul.ois.jhove.module.pdf.PdfSimpleObject@757942a1 Item: Title: Metagenome Functional Prediction Destination: edu.harvard.hul.ois.jhove.module.pdf.PdfSimpleObject@4a87761d Item: Title: Statistical Analysis Destination: edu.harvard.hul.ois.jhove.module.pdf.PdfSimpleObject@66d1af89 Item: Title: Results Destination: edu.harvard.hul.ois.jhove.module.pdf.PdfSimpleObject@8646db9 Children: Item: Title: Dysbiosis by Oral Antibiotics Improve Motor Function of TMEV Mice Destination: edu.harvard.hul.ois.jhove.module.pdf.PdfSimpleObject@37374a5e Item: Title: Oral Administration of Probiotics Modifies Microbiota Recolonization After Antibiotic Cessation, Influencing Deambulatory 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Destination: edu.harvard.hul.ois.jhove.module.pdf.PdfSimpleObject@4671e53b Item: Title: Gut Microbiota Recolonization Modifies the CNS Immunological Changes Provoked by Oral Antibiotic Treatment Destination: edu.harvard.hul.ois.jhove.module.pdf.PdfSimpleObject@2db7a79b Item: Title: Microglial Changes and Axonal Damage Associated With Alterations in the Microbiota During the Chronic Phase of TMEV-IDD Destination: edu.harvard.hul.ois.jhove.module.pdf.PdfSimpleObject@6950e31 Item: Title: Peripheral Immunological Changes in TMEV-IDD Mice Associated With Oral Antibiotic Treatment and Recolonization With or Without 倀爀漀戀椀漀琀椀挀猩㸾൥湤潢樍㐶〠〠潢樍㰼⽁捴楯港䝯呯⽃潵湴‱㌯䑥獴⽳散瑩潮⨮㌯䙩牳琠㐶ㄠ〠刯䱡獴‴㘲‰⁒⽎數琠㐵㜠〠刯偡牥湴‴㐷‰⁒⽐牥瘠㐴㠠〠刯呩瑬攨Materials and Methods Destination: edu.harvard.hul.ois.jhove.module.pdf.PdfSimpleObject@b7dd107 Item: Title: Discussion Destination: edu.harvard.hul.ois.jhove.module.pdf.PdfSimpleObject@42eca56e Item: Title: Data Availability Destination: edu.harvard.hul.ois.jhove.module.pdf.PdfSimpleObject@52f759d7 Item: Title: Ethics Statement Destination: edu.harvard.hul.ois.jhove.module.pdf.PdfSimpleObject@7cbd213e Item: Title: Author Contributions Destination: edu.harvard.hul.ois.jhove.module.pdf.PdfSimpleObject@192d3247 Item: Title: Funding Destination: edu.harvard.hul.ois.jhove.module.pdf.PdfSimpleObject@3ecd23d9 Item: Title: Acknowledgments Destination: edu.harvard.hul.ois.jhove.module.pdf.PdfSimpleObject@569cfc36 Item: Title: Supplementary Material Destination: edu.harvard.hul.ois.jhove.module.pdf.PdfSimpleObject@43bd930a Item: Title: References Destination: edu.harvard.hul.ois.jhove.module.pdf.PdfSimpleObject@33723e30 Info: Title: Manipulation of Gut Microbiota Influences Immune Responses, Axon Preservation, and Motor Disability in a Model of Progressive Multiple Sclerosis Author: Leyre Mestre and Carmen Guaza Subject: Gut microbiota dysbiosis has been implicated in MS and other immune diseases, although it remains unclear how manipulating the gut microbiota may affect the disease course. Keywords: Theiler's virus model, gut microbiota, Treg and Breg cells, neuroinflammation, multiple sclerosis Creator: LaTeX with hyperref package + hypdvips Producer: dvips + MiKTeX GPL Ghostscript 9.0 CreationDate: Fri Jun 14 09:48:48 CEST 2019 ModDate: Wed Jul 21 12:42:52 CEST 2021 ID: 0xe1a71b05d263bc55f6eb32a6d2ab1c11, 0x4825b6f86a2b244fb0614ff55143dc06 Filters: FilterPipeline: FlateDecode FilterPipeline: DCTDecode Images: Image: NisoImageMetadata: FormatName: image/jpg CompressionScheme: JPEG ImageWidth: 1804 ImageHeight: 2480 BitsPerSample: 8 BitsPerSampleUnit: integer Interpolate: true Image: NisoImageMetadata: FormatName: image/jpg CompressionScheme: JPEG ImageWidth: 1981 ImageHeight: 2480 BitsPerSample: 8 BitsPerSampleUnit: integer Interpolate: true Image: NisoImageMetadata: FormatName: image/jpg CompressionScheme: JPEG ImageWidth: 4016 ImageHeight: 4673 BitsPerSample: 8 BitsPerSampleUnit: integer Interpolate: true Image: NisoImageMetadata: FormatName: image/jpg 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2021-07-21T12:42:52+02:00 2019-06-14T12:48:48+05:30 LaTeX with hyperref package + hypdvips 2021-07-21T12:42:52+02:00 26f13367-90d0-11e9-0000-4dec1a4a53f2 uuid:b39955b8-f97d-477b-9612-fccf5e1dad7c application/pdf Manipulation of Gut Microbiota Influences Immune Responses, Axon Preservation, and Motor Disability in a Model of Progressive Multiple Sclerosis Leyre Mestre and Carmen Guaza Gut microbiota dysbiosis has been implicated in MS and other immune diseases, although it remains unclear how manipulating the gut microbiota may affect the disease course. Gut microbiota dysbiosis has been implicated in MS and other immune diseases, although it remains unclear how manipulating the gut microbiota may affect the disease course. 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