a6bd850e390af4532550068b865af736  pdf_223671.pdf
5b6387d6ad0e0a72d5eafb712ec954e4508e9ad6  pdf_223671.pdf
8cbaa51b13454f3fe0564fd2d0dc73c53e4862ff5a3491d87edd8e77e6f852e6  pdf_223671.pdf

Title:          Expression of CD20 after viral reactivation renders HIV-reservoir cells susceptible to Rituximab
Subject:        Nature Communications, doi:10.1038/s41467-019-11556-4
Keywords:       
Author:         Carla Serra-Peinado
Creator:        Springer
Producer:       iText® 5.3.5 ©2000-2012 1T3XT BVBA (AGPL-version)
CreationDate:   Fri Aug  9 05:32:47 2019 CEST
ModDate:        Fri Apr 16 13:58:05 2021 CEST
Tagged:         no
UserProperties: no
Suspects:       no
Form:           AcroForm
JavaScript:     no
Pages:          15
Encrypted:      no
Page size:      595.276 x 782.362 pts
Page rot:       0
File size:      4816393 bytes
Optimized:      yes
PDF version:    1.4


name                                 type              encoding         emb sub uni object ID
------------------------------------ ----------------- ---------------- --- --- --- ---------
IKBGOM+AdvOTea1a7398                 Type 1C           WinAnsi          yes yes no     743  0
IKBLLA+AdvOTea1a7398+fb              Type 1C           Custom           yes yes yes    750  0
IKBLLB+AdvTTab7e17fd                 Type 1C           WinAnsi          yes yes no     755  0
IKBLMB+AdvOTcb88df00                 Type 1C           WinAnsi          yes yes no     756  0
Arial-BoldMT                         Type 1C           WinAnsi          yes no  no     757  0
IKBMBB+AdvOTf23bb480                 Type 1C           WinAnsi          yes yes no     758  0
IKBMBC+AdvOTf23bb480+20              Type 1C           WinAnsi          yes yes no     759  0
IKBMBD+AdvTTda6f6cb8.B               Type 1C           WinAnsi          yes yes no     764  0
IKBMHD+AdvOT1ef757c0                 Type 1C           WinAnsi          yes yes no     280  0
IKBMHE+AdvOT1ef757c0+20              Type 1C           WinAnsi          yes yes no     292  0
IKBMHF+AdvOT1ef757c0+fb              Type 1C           Custom           yes yes yes    284  0
IKBMIG+AdvTTab7e17fd+22              Type 1C           Custom           yes yes no     282  0
IKBMIH+AdvOTb65e897d.B               Type 1C           WinAnsi          yes yes no     294  0
IKBMJH+AdvTT7b515deb                 Type 1C           WinAnsi          yes yes no     291  0
IKBMGD+AdvOT125c650c                 Type 1C           WinAnsi          yes yes no     295  0
IKCBKJ+Helvetica-Bold                Type 1C           WinAnsi          yes yes no     312  0
IKCBOJ+Helvetica                     Type 1C           WinAnsi          yes yes no     303  0
IKCBPJ+Helvetica-Oblique             Type 1C           WinAnsi          yes yes no     309  0
Symbol                               Type 1C           WinAnsi          yes no  no     306  0
IKCCPF+AdvOT9bd21c25.I               Type 1C           WinAnsi          yes yes no     328  0
IKCDAG+AdvOT8608a8d1                 Type 1C           WinAnsi          yes yes no     334  0
IKCDAH+AdvOTea1a7398+20              Type 1C           WinAnsi          yes yes no     329  0
Helvetica2                           Type 1C           WinAnsi          yes no  no     343  0
IKCJDD+AdvOT7d6df7ab.I               Type 1C           WinAnsi          yes yes no     364  0
IKEGKP+AdvOTcb88df00+fb              Type 1C           Custom           yes yes yes    420  0
IKEGLA+AdvOT1ef757c0+21              Type 1C           WinAnsi          yes yes no     421  0
IKEGLB+AdvOT8608a8d1+20              Type 1C           Custom           yes yes yes    425  0
IKEGNB+AdvOT1ef757c0+03              Type 1C           Custom           yes yes yes    426  0
IKEHEP+AdvOT7d6df7ab.I+fb            Type 1C           Custom           yes yes yes    427  0
IKEHHP+AdvOTb65e897d.B+20            Type 1C           WinAnsi          yes yes no     437  0


Jhove (Rel. 1.22.1, 2019-04-17)
 Date: 2021-04-29 02:34:20 CEST
 RepresentationInformation: pdf_223671.pdf
  ReportingModule: PDF-hul, Rel. 1.12.1 (2019-04-17)
  LastModified: 2021-04-16 14:00:43 CEST
  Size: 4816393
  Format: PDF
  Version: 1.4
  Status: Well-Formed, but not valid
  SignatureMatches:
   PDF-hul
  ID: PDF-HUL-122
  ErrorMessage: edu.harvard.hul.ois.jhove.module.pdf.PdfInvalidException: Invalid indirect destination - referenced object 'bm_CR3' cannot be found
   Offset: 4765646
  ID: PDF-HUL-122
  ErrorMessage: edu.harvard.hul.ois.jhove.module.pdf.PdfInvalidException: Invalid indirect destination - referenced object 'bm_CR12' cannot be found
   Offset: 4765646
  ID: PDF-HUL-122
  ErrorMessage: edu.harvard.hul.ois.jhove.module.pdf.PdfInvalidException: Invalid indirect destination - referenced object 'bm_CR12' cannot be found
   Offset: 4765646
  ID: PDF-HUL-122
  ErrorMessage: edu.harvard.hul.ois.jhove.module.pdf.PdfInvalidException: Invalid indirect destination - referenced object 'bm_CR13' cannot be found
   Offset: 4765646
  ID: PDF-HUL-122
  ErrorMessage: edu.harvard.hul.ois.jhove.module.pdf.PdfInvalidException: Invalid indirect destination - referenced object 'bm_CR14' cannot be found
   Offset: 4765646
  ID: PDF-HUL-122
  ErrorMessage: edu.harvard.hul.ois.jhove.module.pdf.PdfInvalidException: Invalid indirect destination - referenced object 'bm_CR11' cannot be found
   Offset: 4765646
  ID: PDF-HUL-122
  ErrorMessage: edu.harvard.hul.ois.jhove.module.pdf.PdfInvalidException: Invalid indirect destination - referenced object 'bm_CR11' cannot be found
   Offset: 4765646
  ID: PDF-HUL-122
  ErrorMessage: edu.harvard.hul.ois.jhove.module.pdf.PdfInvalidException: Invalid indirect destination - referenced object 'bm_CR12' cannot be found
   Offset: 4765646
  ID: PDF-HUL-122
  ErrorMessage: edu.harvard.hul.ois.jhove.module.pdf.PdfInvalidException: Invalid indirect destination - referenced object 'bm_CR12' cannot be found
   Offset: 4765646
  ID: PDF-HUL-122
  ErrorMessage: edu.harvard.hul.ois.jhove.module.pdf.PdfInvalidException: Invalid indirect destination - referenced object 'bm_CR15' cannot be found
   Offset: 4765646
  ID: PDF-HUL-122
  ErrorMessage: edu.harvard.hul.ois.jhove.module.pdf.PdfInvalidException: Invalid indirect destination - referenced object 'bm_CR16' cannot be found
   Offset: 4765646
  ID: PDF-HUL-122
  ErrorMessage: edu.harvard.hul.ois.jhove.module.pdf.PdfInvalidException: Invalid indirect destination - referenced object 'bm_CR17' cannot be found
   Offset: 4765646
  ID: PDF-HUL-122
  ErrorMessage: edu.harvard.hul.ois.jhove.module.pdf.PdfInvalidException: Invalid indirect destination - referenced object 'bm_CR18' cannot be found
   Offset: 4765646
  ID: PDF-HUL-122
  ErrorMessage: edu.harvard.hul.ois.jhove.module.pdf.PdfInvalidException: Invalid indirect destination - referenced object 'bm_CR19' cannot be found
   Offset: 4765646
  ID: PDF-HUL-122
  ErrorMessage: edu.harvard.hul.ois.jhove.module.pdf.PdfInvalidException: Invalid indirect destination - referenced object 'bm_CR20' cannot be found
   Offset: 4765646
  ID: PDF-HUL-122
  ErrorMessage: edu.harvard.hul.ois.jhove.module.pdf.PdfInvalidException: Invalid indirect destination - referenced object 'bm_CR21' cannot be found
   Offset: 4765646
  ID: PDF-HUL-122
  ErrorMessage: edu.harvard.hul.ois.jhove.module.pdf.PdfInvalidException: Invalid indirect destination - referenced object 'bm_CR22' cannot be found
   Offset: 4765646
  ID: PDF-HUL-122
  ErrorMessage: edu.harvard.hul.ois.jhove.module.pdf.PdfInvalidException: Invalid indirect destination - referenced object 'bm_CR23' cannot be found
   Offset: 4765646
  ID: PDF-HUL-122
  ErrorMessage: edu.harvard.hul.ois.jhove.module.pdf.PdfInvalidException: Invalid indirect destination - referenced object 'bm_CR24' cannot be found
   Offset: 4765646
  ID: PDF-HUL-122
  ErrorMessage: edu.harvard.hul.ois.jhove.module.pdf.PdfInvalidException: Invalid indirect destination - referenced object 'bm_CR25' cannot be found
   Offset: 4765646
  ID: PDF-HUL-122
  ErrorMessage: edu.harvard.hul.ois.jhove.module.pdf.PdfInvalidException: Invalid indirect destination - referenced object 'bm_CR25' cannot be found
   Offset: 4765646
  ID: PDF-HUL-122
  ErrorMessage: edu.harvard.hul.ois.jhove.module.pdf.PdfInvalidException: Invalid indirect destination - referenced object 'bm_CR26' cannot be found
   Offset: 4765646
  ID: PDF-HUL-122
  ErrorMessage: edu.harvard.hul.ois.jhove.module.pdf.PdfInvalidException: Invalid indirect destination - referenced object 'bm_CR27' cannot be found
   Offset: 4765646
  ID: PDF-HUL-122
  ErrorMessage: edu.harvard.hul.ois.jhove.module.pdf.PdfInvalidException: Invalid indirect destination - referenced object 'bm_CR28' cannot be found
   Offset: 4765646
  ID: PDF-HUL-122
  ErrorMessage: edu.harvard.hul.ois.jhove.module.pdf.PdfInvalidException: Invalid indirect destination - referenced object 'bm_CR17' cannot be found
   Offset: 4765646
  ID: PDF-HUL-122
  ErrorMessage: edu.harvard.hul.ois.jhove.module.pdf.PdfInvalidException: Invalid indirect destination - referenced object 'bm_CR29' cannot be found
   Offset: 4765646
  ID: PDF-HUL-122
  ErrorMessage: edu.harvard.hul.ois.jhove.module.pdf.PdfInvalidException: Invalid indirect destination - referenced object 'bm_CR30' cannot be found
   Offset: 4765646
  ID: PDF-HUL-122
  ErrorMessage: edu.harvard.hul.ois.jhove.module.pdf.PdfInvalidException: Invalid indirect destination - referenced object 'bm_CR31' cannot be found
   Offset: 4765646
  ID: PDF-HUL-122
  ErrorMessage: edu.harvard.hul.ois.jhove.module.pdf.PdfInvalidException: Invalid indirect destination - referenced object 'bm_CR32' cannot be found
   Offset: 4765646
  ID: PDF-HUL-122
  ErrorMessage: edu.harvard.hul.ois.jhove.module.pdf.PdfInvalidException: Invalid indirect destination - referenced object 'bm_CR33' cannot be found
   Offset: 4765646
  ID: PDF-HUL-122
  ErrorMessage: edu.harvard.hul.ois.jhove.module.pdf.PdfInvalidException: Invalid indirect destination - referenced object 'bm_CR36' cannot be found
   Offset: 4765646
  ID: PDF-HUL-122
  ErrorMessage: edu.harvard.hul.ois.jhove.module.pdf.PdfInvalidException: Invalid indirect destination - referenced object 'bm_CR40' cannot be found
   Offset: 4765646
  ID: PDF-HUL-122
  ErrorMessage: edu.harvard.hul.ois.jhove.module.pdf.PdfInvalidException: Invalid indirect destination - referenced object 'bm_CR41' cannot be found
   Offset: 4765646
  ID: PDF-HUL-122
  ErrorMessage: edu.harvard.hul.ois.jhove.module.pdf.PdfInvalidException: Invalid indirect destination - referenced object 'bm_CR42' cannot be found
   Offset: 4765646
  ID: PDF-HUL-122
  ErrorMessage: edu.harvard.hul.ois.jhove.module.pdf.PdfInvalidException: Invalid indirect destination - referenced object 'bm_CR43' cannot be found
   Offset: 4765646
  ID: PDF-HUL-122
  ErrorMessage: edu.harvard.hul.ois.jhove.module.pdf.PdfInvalidException: Invalid indirect destination - referenced object 'bm_CR44' cannot be found
   Offset: 4765646
  ID: PDF-HUL-122
  ErrorMessage: edu.harvard.hul.ois.jhove.module.pdf.PdfInvalidException: Invalid indirect destination - referenced object 'bm_CR45' cannot be found
   Offset: 4765646
  ID: PDF-HUL-122
  ErrorMessage: edu.harvard.hul.ois.jhove.module.pdf.PdfInvalidException: Invalid indirect destination - referenced object 'bm_CR46' cannot be found
   Offset: 4765646
  ID: PDF-HUL-122
  ErrorMessage: edu.harvard.hul.ois.jhove.module.pdf.PdfInvalidException: Invalid indirect destination - referenced object 'bm_CR47' cannot be found
   Offset: 4765646
  MIMEtype: application/pdf
  Profile: Linearized PDF
  PDFMetadata: 
   Objects: 900
   FreeObjects: 1
   IncrementalUpdates: 1
   DocumentCatalog: 
    PageLayout: SinglePage
    PageMode: UseOutlines
    Language: EN
    Outlines: 
     Item: 
      Title: Expression of CD20 after viral reactivation renders HIV-reservoir cells susceptible to Rituximab
      Destination: edu.harvard.hul.ois.jhove.module.pdf.PdfSimpleObject@11758f2a
      Children: 
       Item: 
        Title: Results
        Destination: edu.harvard.hul.ois.jhove.module.pdf.PdfSimpleObject@e720b71
        Children: 
         Item: 
          Title: A subset of CD4+ T’cells expresses CD20 in HIV infection
          Destination: edu.harvard.hul.ois.jhove.module.pdf.PdfSimpleObject@1b26f7b2
         Item: 
          Title: CD20dim CD4+ T’cells are enriched in intracellular HIV RNA
          Destination: edu.harvard.hul.ois.jhove.module.pdf.PdfSimpleObject@491cc5c9
         Item: 
          Title: Proviral HIV DNA levels of CD20dim CD4+ T’cells
          Destination: edu.harvard.hul.ois.jhove.module.pdf.PdfSimpleObject@74ad1f1f
         Item: 
          Title: CD20+ T’cells are infected in human lymph nodes
          Destination: edu.harvard.hul.ois.jhove.module.pdf.PdfSimpleObject@6a1aab78
         Item: 
          Title: HIV upregulates CD20 in T’cells during early viral infection
          Destination: edu.harvard.hul.ois.jhove.module.pdf.PdfSimpleObject@462d5aee
         Item: 
          Title: Rituximab targets HIV-infected CD20dim CD4+ T’cells in’vitro
          Destination: edu.harvard.hul.ois.jhove.module.pdf.PdfSimpleObject@69b0fd6f
         Item: 
          Title: In vivo administration of Rituximab targets HIV-RNA+ cells
          Destination: edu.harvard.hul.ois.jhove.module.pdf.PdfSimpleObject@757942a1
         Item: 
          Title: Rituximab impacts HIV+ cells after viral reactivation
          Destination: edu.harvard.hul.ois.jhove.module.pdf.PdfSimpleObject@4a87761d
       Item: 
        Title: Discussion
        Destination: edu.harvard.hul.ois.jhove.module.pdf.PdfSimpleObject@66d1af89
       Item: 
        Title: Methods
        Destination: edu.harvard.hul.ois.jhove.module.pdf.PdfSimpleObject@8646db9
        Children: 
         Item: 
          Title: Ethics statement
          Destination: edu.harvard.hul.ois.jhove.module.pdf.PdfSimpleObject@37374a5e
         Item: 
          Title: Study samples
          Destination: edu.harvard.hul.ois.jhove.module.pdf.PdfSimpleObject@4671e53b
         Item: 
          Title: Cells and virus
          Destination: edu.harvard.hul.ois.jhove.module.pdf.PdfSimpleObject@2db7a79b
         Item: 
          Title: Phenotyping of CD4+ T’cells
          Destination: edu.harvard.hul.ois.jhove.module.pdf.PdfSimpleObject@6950e31
         Item: 
          Title: Quantification of HIV DNA and HIV RNA by quantitative PCR
          Destination: edu.harvard.hul.ois.jhove.module.pdf.PdfSimpleObject@b7dd107
         Item: 
          Title: Detection of HIV RNA+ cells by the RNA FISH-flow assay
          Destination: edu.harvard.hul.ois.jhove.module.pdf.PdfSimpleObject@42eca56e
         Item: 
          Title: Fluorescence activated cell sorting of CD4+ T’cells
          Destination: edu.harvard.hul.ois.jhove.module.pdf.PdfSimpleObject@52f759d7
         Item: 
          Title: Immunohistochemistry of human lymph nodes
          Destination: edu.harvard.hul.ois.jhove.module.pdf.PdfSimpleObject@7cbd213e
         Item: 
          Title: Detection of RNA in lymph nodes by in’situ hybridization
          Destination: edu.harvard.hul.ois.jhove.module.pdf.PdfSimpleObject@192d3247
         Item: 
          Title: Confocal microscopy and quantification
          Destination: edu.harvard.hul.ois.jhove.module.pdf.PdfSimpleObject@3ecd23d9
         Item: 
          Title: Ex vivo infection of unstimulated PBMCs
          Destination: edu.harvard.hul.ois.jhove.module.pdf.PdfSimpleObject@569cfc36
         Item: 
          Title: Ex vivo infection of CD20− CD4+ T’cells
          Destination: edu.harvard.hul.ois.jhove.module.pdf.PdfSimpleObject@43bd930a
         Item: 
          Title: Quantification of cell death after Rituximab treatment
          Destination: edu.harvard.hul.ois.jhove.module.pdf.PdfSimpleObject@33723e30
         Item: 
          Title: Ex vivo viral reactivation of CD4+ T’cells
          Destination: edu.harvard.hul.ois.jhove.module.pdf.PdfSimpleObject@64f6106c
         Item: 
          Title: Quantification of HIV RNA after viral reactivation
          Destination: edu.harvard.hul.ois.jhove.module.pdf.PdfSimpleObject@553a3d88
         Item: 
          Title: Cell activation
          Destination: edu.harvard.hul.ois.jhove.module.pdf.PdfSimpleObject@7a30d1e6
         Item: 
          Title: Statistical analyses
          Destination: edu.harvard.hul.ois.jhove.module.pdf.PdfSimpleObject@5891e32e
         Item: 
          Title: Reporting summary
          Destination: edu.harvard.hul.ois.jhove.module.pdf.PdfSimpleObject@cb0ed20
       Item: 
        Title: Data availability
        Destination: edu.harvard.hul.ois.jhove.module.pdf.PdfSimpleObject@8e24743
       Item: 
        Title: References
        Destination: edu.harvard.hul.ois.jhove.module.pdf.PdfSimpleObject@74a10858
       Item: 
        Title: Acknowledgements
        Destination: edu.harvard.hul.ois.jhove.module.pdf.PdfSimpleObject@23fe1d71
       Item: 
        Title: Author contributions
        Destination: edu.harvard.hul.ois.jhove.module.pdf.PdfSimpleObject@28ac3dc3
       Item: 
        Title: Additional information
        Destination: edu.harvard.hul.ois.jhove.module.pdf.PdfSimpleObject@32eebfca
   Info: 
    Title: Expression of CD20 after viral reactivation renders HIV-reservoir cells susceptible to Rituximab
    Author: Carla Serra-Peinado
    Subject: Nature Communications, doi:10.1038/s41467-019-11556-4
    Keywords: 
    Creator: Springer
    Producer: iText® 5.3.5 ©2000-2012 1T3XT BVBA (AGPL-version)
    CreationDate: Fri Aug 09 06:02:47 CEST 2019
    ModDate: Fri Apr 16 13:58:05 CEST 2021
   ID: 0x7c99321528cfbec0671cffb8ad973b61, 0x6daa7befd8fdf3498b2fca0f8ddf5601
   Filters: 
    FilterPipeline: FlateDecode
    FilterPipeline: DCTDecode
   Images: 
    Image: 
     NisoImageMetadata: 
      FormatName: image/png
      ImageWidth: 1166
      ImageHeight: 553
      ColorSpace: RGB
      BitsPerSample: 8
      BitsPerSampleUnit: integer
     Filter: FlateDecode
     Intent: Perceptual
    Image: 
     NisoImageMetadata: 
      FormatName: image/jpg
      CompressionScheme: JPEG
      ImageWidth: 1202
      ImageHeight: 208
      ColorSpace: RGB
      BitsPerSample: 8
      BitsPerSampleUnit: integer
     Intent: Perceptual
    Image: 
     NisoImageMetadata: 
      FormatName: image/png
      ImageWidth: 1202
      ImageHeight: 418
      ColorSpace: RGB
      BitsPerSample: 8
      BitsPerSampleUnit: integer
     Filter: FlateDecode
     Intent: Perceptual
    Image: 
     NisoImageMetadata: 
      FormatName: image/png
      ImageWidth: 1911
      ImageHeight: 1074
      ColorSpace: RGB
      BitsPerSample: 8
      BitsPerSampleUnit: integer
     Filter: FlateDecode
     Intent: Perceptual
    Image: 
     NisoImageMetadata: 
      FormatName: image/jpg
      CompressionScheme: JPEG
      ImageWidth: 1079
      ImageHeight: 597
      ColorSpace: RGB
      BitsPerSample: 8
      BitsPerSampleUnit: integer
     Intent: Perceptual
    Image: 
     NisoImageMetadata: 
      FormatName: image/png
      ImageWidth: 1048
      ImageHeight: 601
      ColorSpace: RGB
      BitsPerSample: 8
      BitsPerSampleUnit: integer
     Filter: FlateDecode
     Intent: Perceptual
    Image: 
     NisoImageMetadata: 
      FormatName: image/png
      ImageWidth: 933
      ImageHeight: 601
      ColorSpace: RGB
      BitsPerSample: 8
      BitsPerSampleUnit: integer
     Filter: FlateDecode
     Intent: Perceptual
    Image: 
     NisoImageMetadata: 
      FormatName: image/png
      ImageWidth: 1815
      ImageHeight: 642
      ColorSpace: RGB
      BitsPerSample: 8
      BitsPerSampleUnit: integer
     Filter: FlateDecode
     Intent: Perceptual
    Image: 
     NisoImageMetadata: 
      FormatName: image/png
      ImageWidth: 326
      ImageHeight: 324
      ColorSpace: RGB
      BitsPerSample: 8
      BitsPerSampleUnit: integer
     Filter: FlateDecode
     Intent: Perceptual
    Image: 
     NisoImageMetadata: 
      FormatName: image/png
      ImageWidth: 325
      ImageHeight: 324
      ColorSpace: RGB
      BitsPerSample: 8
      BitsPerSampleUnit: integer
     Filter: FlateDecode
     Intent: Perceptual
    Image: 
     NisoImageMetadata: 
      FormatName: image/png
      ImageWidth: 325
      ImageHeight: 324
      ColorSpace: RGB
      BitsPerSample: 8
      BitsPerSampleUnit: integer
     Filter: FlateDecode
     Intent: Perceptual
    Image: 
     NisoImageMetadata: 
      FormatName: image/png
      ImageWidth: 325
      ImageHeight: 324
      ColorSpace: RGB
      BitsPerSample: 8
      BitsPerSampleUnit: integer
     Filter: FlateDecode
     Intent: Perceptual
    Image: 
     NisoImageMetadata: 
      FormatName: image/png
      ImageWidth: 1920
      ImageHeight: 679
      ColorSpace: RGB
      BitsPerSample: 8
      BitsPerSampleUnit: integer
     Filter: FlateDecode
     Intent: Perceptual
    Image: 
     NisoImageMetadata: 
      FormatName: image/png
      ImageWidth: 1100
      ImageHeight: 90
      ColorSpace: black is zero
      BitsPerSample: 1
      BitsPerSampleUnit: integer
     Filter: FlateDecode
   Fonts: 
    Type1: 
     Font: 
      BaseFont: IKCCPF+AdvOT9bd21c25.I
      FontSubset: true
      FirstChar: 70
      LastChar: 117
      FontDescriptor: 
       FontName: IKCCPF+AdvOT9bd21c25.I
       Flags: Nonsymbolic
       FontBBox: -83, -197, 1010, 906
       FontFile3: true
      Encoding: WinAnsiEncoding
     Font: 
      BaseFont: IKCDAH+AdvOTea1a7398+20
      FontSubset: true
      FirstChar: 146
      LastChar: 150
      FontDescriptor: 
       FontName: IKCDAH+AdvOTea1a7398+20
       Flags: Nonsymbolic
       FontBBox: -93, -197, 843, 791
       FontFile3: true
      Encoding: WinAnsiEncoding
     Font: 
      BaseFont: IKCDAG+AdvOT8608a8d1
      FontSubset: true
      FirstChar: 181
      LastChar: 181
      FontDescriptor: 
       FontName: IKCDAG+AdvOT8608a8d1
       Flags: Nonsymbolic
       FontBBox: -62, -208, 927, 958
       FontFile3: true
      Encoding: WinAnsiEncoding
     Font: 
      BaseFont: Helvetica2
      FirstChar: 32
      LastChar: 150
      FontDescriptor: 
       FontName: Helvetica2
       Flags: Nonsymbolic
       FontBBox: -166, -225, 1000, 931
       FontFile3: true
      Encoding: WinAnsiEncoding
     Font: 
      BaseFont: IKBMHD+AdvOT1ef757c0
      FontSubset: true
      FirstChar: 35
      LastChar: 243
      FontDescriptor: 
       FontName: IKBMHD+AdvOT1ef757c0
       Flags: Serif, Nonsymbolic
       FontBBox: -20, -250, 947, 854
       FontFile3: true
      Encoding: WinAnsiEncoding
     Font: 
      BaseFont: IKBMIG+AdvTTab7e17fd+22
      FontSubset: true
      FirstChar: 21
      LastChar: 21
      FontDescriptor: 
       FontName: IKBMIG+AdvTTab7e17fd+22
       Flags: Nonsymbolic
       FontBBox: -156, -218, 937, 947
       FontFile3: true
      EncodingDictionary: 
       BaseEncoding: WinAnsiEncoding
       Differences: true
     Font: 
      BaseFont: IKBMHF+AdvOT1ef757c0+fb
      FontSubset: true
      FirstChar: 1
      LastChar: 3
      FontDescriptor: 
       FontName: IKBMHF+AdvOT1ef757c0+fb
       Flags: Symbolic
       FontBBox: 0, -10, 781, 708
       FontFile3: true
      EncodingDictionary: 
       Differences: true
      ToUnicode: true
     Font: 
      BaseFont: IKBMJH+AdvTT7b515deb
      FontSubset: true
      FirstChar: 174
      LastChar: 174
      FontDescriptor: 
       FontName: IKBMJH+AdvTT7b515deb
       Flags: Nonsymbolic
       FontBBox: -93, -187, 854, 843
       FontFile3: true
      Encoding: WinAnsiEncoding
     Font: 
      BaseFont: IKBMHE+AdvOT1ef757c0+20
      FontSubset: true
      FirstChar: 146
      LastChar: 150
      FontDescriptor: 
       FontName: IKBMHE+AdvOT1ef757c0+20
       Flags: Nonsymbolic
       FontBBox: -135, -187, 1010, 833
       FontFile3: true
      Encoding: WinAnsiEncoding
     Font: 
      BaseFont: IKEGKP+AdvOTcb88df00+fb
      FontSubset: true
      FirstChar: 1
      LastChar: 3
      FontDescriptor: 
       FontName: IKEGKP+AdvOTcb88df00+fb
       Flags: Symbolic
       FontBBox: 0, -197, 895, 791
       FontFile3: true
      EncodingDictionary: 
       Differences: true
      ToUnicode: true
     Font: 
      BaseFont: IKEGLA+AdvOT1ef757c0+21
      FontSubset: true
      FirstChar: 153
      LastChar: 153
      FontDescriptor: 
       FontName: IKEGLA+AdvOT1ef757c0+21
       Flags: Nonsymbolic
       FontBBox: 0, -20, 822, 697
       FontFile3: true
      Encoding: WinAnsiEncoding
     Font: 
      BaseFont: IKBMIH+AdvOTb65e897d.B
      FontSubset: true
      FirstChar: 45
      LastChar: 121
      FontDescriptor: 
       FontName: IKBMIH+AdvOTb65e897d.B
       Flags: Serif, Nonsymbolic
       FontBBox: -20, -250, 968, 854
       FontFile3: true
      Encoding: WinAnsiEncoding
     Font: 
      BaseFont: IKBGOM+AdvOTea1a7398
      FontSubset: true
      FirstChar: 35
      LastChar: 243
      FontDescriptor: 
       FontName: IKBGOM+AdvOTea1a7398
       Flags: Nonsymbolic
       FontBBox: -31, -197, 979, 906
       FontFile3: true
      Encoding: WinAnsiEncoding
     Font: 
      BaseFont: IKBMGD+AdvOT125c650c
      FontSubset: true
      FirstChar: 72
      LastChar: 72
      FontDescriptor: 
       FontName: IKBMGD+AdvOT125c650c
       Flags: Nonsymbolic
       FontBBox: -31, -197, 979, 906
       FontFile3: true
      Encoding: WinAnsiEncoding
     Font: 
      BaseFont: IKEGLB+AdvOT8608a8d1+20
      FontSubset: true
      FirstChar: 1
      LastChar: 1
      FontDescriptor: 
       FontName: IKEGLB+AdvOT8608a8d1+20
       Flags: Symbolic
       FontBBox: -968, -333, 2000, 1020
       FontFile3: true
      EncodingDictionary: 
       Differences: true
      ToUnicode: true
     Font: 
      BaseFont: IKEGNB+AdvOT1ef757c0+03
      FontSubset: true
      FirstChar: 1
      LastChar: 3
      FontDescriptor: 
       FontName: IKEGNB+AdvOT1ef757c0+03
       Flags: Symbolic
       FontBBox: -125, -270, 854, 791
       FontFile3: true
      EncodingDictionary: 
       Differences: true
      ToUnicode: true
     Font: 
      BaseFont: IKEHEP+AdvOT7d6df7ab.I+fb
      FontSubset: true
      FirstChar: 1
      LastChar: 1
      FontDescriptor: 
       FontName: IKEHEP+AdvOT7d6df7ab.I+fb
       Flags: Symbolic
       FontBBox: -156, -250, 802, 708
       FontFile3: true
      EncodingDictionary: 
       Differences: true
      ToUnicode: true
     Font: 
      BaseFont: IKCJDD+AdvOT7d6df7ab.I
      FontSubset: true
      FirstChar: 44
      LastChar: 121
      FontDescriptor: 
       FontName: IKCJDD+AdvOT7d6df7ab.I
       Flags: Nonsymbolic
       FontBBox: -135, -250, 1000, 854
       FontFile3: true
      Encoding: WinAnsiEncoding
     Font: 
      BaseFont: IKBLLA+AdvOTea1a7398+fb
      FontSubset: true
      FirstChar: 1
      LastChar: 3
      FontDescriptor: 
       FontName: IKBLLA+AdvOTea1a7398+fb
       Flags: Symbolic
       FontBBox: 0, -197, 750, 791
       FontFile3: true
      EncodingDictionary: 
       Differences: true
      ToUnicode: true
     Font: 
      BaseFont: IKCBOJ+Helvetica
      FontSubset: true
      FirstChar: 32
      LastChar: 150
      FontDescriptor: 
       FontName: IKCBOJ+Helvetica
       Flags: Nonsymbolic
       FontBBox: -166, -225, 1000, 931
       FontFile3: true
      Encoding: WinAnsiEncoding
     Font: 
      BaseFont: Symbol
      FirstChar: 0
      LastChar: 255
      FontDescriptor: 
       FontName: Symbol
       Flags: Nonsymbolic
       FontBBox: -180, -293, 1090, 1010
       FontFile3: true
      Encoding: WinAnsiEncoding
     Font: 
      BaseFont: IKBLLB+AdvTTab7e17fd
      FontSubset: true
      FirstChar: 43
      LastChar: 61
      FontDescriptor: 
       FontName: IKBLLB+AdvTTab7e17fd
       Flags: Nonsymbolic
       FontBBox: -156, -250, 1072, 947
       FontFile3: true
      Encoding: WinAnsiEncoding
     Font: 
      BaseFont: IKBLMB+AdvOTcb88df00
      FontSubset: true
      FirstChar: 45
      LastChar: 122
      FontDescriptor: 
       FontName: IKBLMB+AdvOTcb88df00
       Flags: Nonsymbolic
       FontBBox: -41, -197, 968, 906
       FontFile3: true
      Encoding: WinAnsiEncoding
     Font: 
      BaseFont: Arial-BoldMT
      FirstChar: 0
      LastChar: 255
      FontDescriptor: 
       FontName: Arial-BoldMT
       Flags: Nonsymbolic
       FontBBox: -628, -376, 2000, 1010
       FontFile3: true
      Encoding: WinAnsiEncoding
     Font: 
      BaseFont: IKCBPJ+Helvetica-Oblique
      FontSubset: true
      FirstChar: 70
      LastChar: 114
      FontDescriptor: 
       FontName: IKCBPJ+Helvetica-Oblique
       Flags: Nonsymbolic, Italic
       FontBBox: -170, -225, 1116, 931
       FontFile3: true
      Encoding: WinAnsiEncoding
     Font: 
      BaseFont: IKEHHP+AdvOTb65e897d.B+20
      FontSubset: true
      FirstChar: 146
      LastChar: 146
      FontDescriptor: 
       FontName: IKEHHP+AdvOTb65e897d.B+20
       Flags: Nonsymbolic
       FontBBox: -125, -177, 1052, 822
       FontFile3: true
      Encoding: WinAnsiEncoding
     Font: 
      BaseFont: IKBMBB+AdvOTf23bb480
      FontSubset: true
      FirstChar: 40
      LastChar: 243
      FontDescriptor: 
       FontName: IKBMBB+AdvOTf23bb480
       Flags: Nonsymbolic
       FontBBox: -31, -197, 968, 916
       FontFile3: true
      Encoding: WinAnsiEncoding
     Font: 
      BaseFont: IKBMBC+AdvOTf23bb480+20
      FontSubset: true
      FirstChar: 146
      LastChar: 146
      FontDescriptor: 
       FontName: IKBMBC+AdvOTf23bb480+20
       Flags: Nonsymbolic
       FontBBox: -93, -197, 843, 791
       FontFile3: true
      Encoding: WinAnsiEncoding
     Font: 
      BaseFont: IKCBKJ+Helvetica-Bold
      FontSubset: true
      FirstChar: 67
      LastChar: 103
      FontDescriptor: 
       FontName: IKCBKJ+Helvetica-Bold
       Flags: Nonsymbolic, ForceBold
       FontBBox: -170, -228, 1003, 962
       FontFile3: true
      Encoding: WinAnsiEncoding
     Font: 
      BaseFont: IKBMBD+AdvTTda6f6cb8.B
      FontSubset: true
      FirstChar: 48
      LastChar: 57
      FontDescriptor: 
       FontName: IKBMBD+AdvTTda6f6cb8.B
       Flags: Nonsymbolic
       FontBBox: -72, -218, 895, 927
       FontFile3: true
      Encoding: WinAnsiEncoding
   XMP: <x:xmpmeta xmlns:x="adobe:ns:meta/" x:xmptk="Adobe XMP Core 5.6-c017 91.164464, 2020/06/15-10:20:05        ">
   <rdf:RDF xmlns:rdf="http://www.w3.org/1999/02/22-rdf-syntax-ns#">
      <rdf:Description rdf:about=""
            xmlns:dc="http://purl.org/dc/elements/1.1/"
            xmlns:prism="http://prismstandard.org/namespaces/basic/2.0/"
            xmlns:pdfx="http://ns.adobe.com/pdfx/1.3/"
            xmlns:crossmark="http://crossref.org/crossmark/1.0/"
            xmlns:xmp="http://ns.adobe.com/xap/1.0/"
            xmlns:xmpRights="http://ns.adobe.com/xap/1.0/rights/"
            xmlns:pdf="http://ns.adobe.com/pdf/1.3/"
            xmlns:jav="http://www.niso.org/schemas/jav/1.0/"
            xmlns:xmpMM="http://ns.adobe.com/xap/1.0/mm/"
            xmlns:stEvt="http://ns.adobe.com/xap/1.0/sType/ResourceEvent#"
            xmlns:pdfaid="http://www.aiim.org/pdfa/ns/id/"
            xmlns:sn="http://springernature.com/ns/xmpExtensions/2.0/"
            xmlns:author="http://springernature.com/ns/xmpExtensions/2.0/authorInfo/"
            xmlns:pdfaExtension="http://www.aiim.org/pdfa/ns/extension/"
            xmlns:pdfaSchema="http://www.aiim.org/pdfa/ns/schema#"
            xmlns:pdfaProperty="http://www.aiim.org/pdfa/ns/property#"
            xmlns:pdfaType="http://www.aiim.org/pdfa/ns/type#"
            xmlns:pdfaField="http://www.aiim.org/pdfa/ns/field#">
         <dc:format>application/pdf</dc:format>
         <dc:identifier>doi:10.1038/s41467-019-11556-4</dc:identifier>
         <dc:title>
            <rdf:Alt>
               <rdf:li xml:lang="x-default">Expression of CD20 after viral reactivation renders HIV-reservoir cells susceptible to Rituximab</rdf:li>
            </rdf:Alt>
         </dc:title>
         <dc:creator>
            <rdf:Seq>
               <rdf:li>Carla Serra-Peinado</rdf:li>
               <rdf:li>Judith Grau-Expósito</rdf:li>
               <rdf:li>Laura Luque-Ballesteros</rdf:li>
               <rdf:li>Antonio Astorga-Gamaza</rdf:li>
               <rdf:li>Jordi Navarro</rdf:li>
               <rdf:li>Jenny Gallego-Rodriguez</rdf:li>
               <rdf:li>Mario Martin</rdf:li>
               <rdf:li>Adrià Curran</rdf:li>
               <rdf:li>Joaquin Burgos</rdf:li>
               <rdf:li>Esteban Ribera</rdf:li>
               <rdf:li>Berta Raventós</rdf:li>
               <rdf:li>Rein Willekens</rdf:li>
               <rdf:li>Ariadna Torrella</rdf:li>
               <rdf:li>Bibiana Planas</rdf:li>
               <rdf:li>Rosa Badía</rdf:li>
               <rdf:li>Felipe Garcia</rdf:li>
               <rdf:li>Josep Castellví</rdf:li>
               <rdf:li>Meritxell Genescà</rdf:li>
               <rdf:li>Vicenç Falcó</rdf:li>
               <rdf:li>Maria J. Buzon</rdf:li>
            </rdf:Seq>
         </dc:creator>
         <dc:publisher>
            <rdf:Bag>
               <rdf:li>Springer US</rdf:li>
            </rdf:Bag>
         </dc:publisher>
         <dc:subject>
            <rdf:Bag/>
         </dc:subject>
         <dc:description>
            <rdf:Alt>
               <rdf:li xml:lang="x-default">Nature Communications, doi:10.1038/s41467-019-11556-4</rdf:li>
            </rdf:Alt>
         </dc:description>
         <prism:doi>10.1038/s41467-019-11556-4</prism:doi>
         <prism:url>http://dx.doi.org/10.1038/s41467-019-11556-4</prism:url>
         <prism:aggregationType>journal</prism:aggregationType>
         <prism:publicationName>Nature Communications</prism:publicationName>
         <prism:copyright>© 2019, The Author(s)</prism:copyright>
         <prism:issn>2041-1723</prism:issn>
         <pdfx:doi>10.1038/s41467-019-11556-4</pdfx:doi>
         <pdfx:CrossMarkDomains>
            <rdf:Seq>
               <rdf:li>springer.com</rdf:li>
               <rdf:li>springerlink.com</rdf:li>
            </rdf:Seq>
         </pdfx:CrossMarkDomains>
         <crossmark:MajorVersionDate>2010-04-23</crossmark:MajorVersionDate>
         <crossmark:CrossmarkDomainExclusive>True</crossmark:CrossmarkDomainExclusive>
         <crossmark:DOI>10.1038/s41467-019-11556-4</crossmark:DOI>
         <crossmark:CrossMarkDomains>
            <rdf:Seq>
               <rdf:li>springer.com</rdf:li>
               <rdf:li>springerlink.com</rdf:li>
            </rdf:Seq>
         </crossmark:CrossMarkDomains>
         <xmp:CreatorTool>Springer</xmp:CreatorTool>
         <xmp:ModifyDate>2021-04-16T13:58:05+02:00</xmp:ModifyDate>
         <xmp:CreateDate>2019-08-09T09:02:47+05:30</xmp:CreateDate>
         <xmp:MetadataDate>2021-04-16T13:58:05+02:00</xmp:MetadataDate>
         <xmpRights:Marked>True</xmpRights:Marked>
         <pdf:Keywords/>
         <pdf:Producer>iText® 5.3.5 ©2000-2012 1T3XT BVBA (AGPL-version)</pdf:Producer>
         <jav:journal_article_version>VoR</jav:journal_article_version>
         <xmpMM:DocumentID>uuid:52130cf3-348e-4798-8359-106f10255f44</xmpMM:DocumentID>
         <xmpMM:InstanceID>uuid:22ef5d79-c4d8-4894-8bad-76eb642b7e19</xmpMM:InstanceID>
         <xmpMM:RenditionClass>default</xmpMM:RenditionClass>
         <xmpMM:VersionID>1</xmpMM:VersionID>
         <xmpMM:History>
            <rdf:Seq>
               <rdf:li rdf:parseType="Resource">
                  <stEvt:action>converted</stEvt:action>
                  <stEvt:instanceID>uuid:ea4fbe22-715d-4bae-81df-4986c88b01cd</stEvt:instanceID>
                  <stEvt:parameters>converted to PDF/A-2b</stEvt:parameters>
                  <stEvt:softwareAgent>pdfToolbox</stEvt:softwareAgent>
                  <stEvt:when>2019-08-09T09:03:34+05:30</stEvt:when>
               </rdf:li>
            </rdf:Seq>
         </xmpMM:History>
         <pdfaid:part>2</pdfaid:part>
         <pdfaid:conformance>B</pdfaid:conformance>
         <sn:authorInfo>
            <rdf:Bag>
               <rdf:li rdf:parseType="Resource">
                  <author:name>Carla Serra-Peinado</author:name>
                  <author:orcid>http://orcid.org/0000-0003-1413-3990</author:orcid>
               </rdf:li>
               <rdf:li rdf:parseType="Resource">
                  <author:name>Judith Grau-Expósito</author:name>
                  <author:orcid>http://orcid.org/0000-0001-9350-2429</author:orcid>
               </rdf:li>
               <rdf:li rdf:parseType="Resource">
                  <author:name>Laura Luque-Ballesteros</author:name>
                  <author:orcid>http://orcid.org/0000-0001-9515-5889</author:orcid>
               </rdf:li>
               <rdf:li rdf:parseType="Resource">
                  <author:name>Jordi Navarro</author:name>
                  <author:orcid>http://orcid.org/0000-0002-7187-0367</author:orcid>
               </rdf:li>
               <rdf:li rdf:parseType="Resource">
                  <author:name>Mario Martin</author:name>
                  <author:orcid>http://orcid.org/0000-0001-6435-0374</author:orcid>
               </rdf:li>
               <rdf:li rdf:parseType="Resource">
                  <author:name>Adrià Curran</author:name>
                  <author:orcid>http://orcid.org/0000-0002-1263-0814</author:orcid>
               </rdf:li>
               <rdf:li rdf:parseType="Resource">
                  <author:name>Joaquin Burgos</author:name>
                  <author:orcid>http://orcid.org/0000-0001-8445-3047</author:orcid>
               </rdf:li>
               <rdf:li rdf:parseType="Resource">
                  <author:name>Esteban Ribera</author:name>
                  <author:orcid>http://orcid.org/0000-0002-3752-8808</author:orcid>
               </rdf:li>
               <rdf:li rdf:parseType="Resource">
                  <author:name>Berta Raventós</author:name>
                  <author:orcid>http://orcid.org/0000-0002-4668-2970</author:orcid>
               </rdf:li>
               <rdf:li rdf:parseType="Resource">
                  <author:name>Rein Willekens</author:name>
                  <author:orcid>http://orcid.org/0000-0001-7791-3682</author:orcid>
               </rdf:li>
               <rdf:li rdf:parseType="Resource">
                  <author:name>Ariadna Torrella</author:name>
                  <author:orcid>http://orcid.org/0000-0003-1848-5096</author:orcid>
               </rdf:li>
               <rdf:li rdf:parseType="Resource">
                  <author:name>Bibiana Planas</author:name>
                  <author:orcid>http://orcid.org/0000-0002-1490-7127</author:orcid>
               </rdf:li>
               <rdf:li rdf:parseType="Resource">
                  <author:name>Rosa Badía</author:name>
                  <author:orcid>http://orcid.org/0000-0002-8222-5697</author:orcid>
               </rdf:li>
               <rdf:li rdf:parseType="Resource">
                  <author:name>Felipe Garcia</author:name>
                  <author:orcid>http://orcid.org/0000-0001-7658-5832</author:orcid>
               </rdf:li>
               <rdf:li rdf:parseType="Resource">
                  <author:name>Josep Castellví</author:name>
                  <author:orcid>http://orcid.org/0000-0001-5745-9996</author:orcid>
               </rdf:li>
               <rdf:li rdf:parseType="Resource">
                  <author:name>Vicenç Falcó</author:name>
                  <author:orcid>http://orcid.org/0000-0001-9626-0023</author:orcid>
               </rdf:li>
               <rdf:li rdf:parseType="Resource">
                  <author:name>Maria J. Buzon</author:name>
                  <author:orcid>http://orcid.org/0000-0003-4427-9413</author:orcid>
               </rdf:li>
            </rdf:Bag>
         </sn:authorInfo>
         <pdfaExtension:schemas>
            <rdf:Bag>
               <rdf:li rdf:parseType="Resource">
                  <pdfaSchema:namespaceURI>http://ns.adobe.com/pdf/1.3/</pdfaSchema:namespaceURI>
                  <pdfaSchema:prefix>pdf</pdfaSchema:prefix>
                  <pdfaSchema:schema>Adobe PDF Schema</pdfaSchema:schema>
                  <pdfaSchema:property>
                     <rdf:Seq>
                        <rdf:li rdf:parseType="Resource">
                           <pdfaProperty:category>internal</pdfaProperty:category>
                           <pdfaProperty:description>A name object indicating whether the document has been modified to include trapping information</pdfaProperty:description>
                           <pdfaProperty:name>Trapped</pdfaProperty:name>
                           <pdfaProperty:valueType>Text</pdfaProperty:valueType>
                        </rdf:li>
                     </rdf:Seq>
                  </pdfaSchema:property>
               </rdf:li>
               <rdf:li rdf:parseType="Resource">
                  <pdfaSchema:namespaceURI>http://ns.adobe.com/pdfx/1.3/</pdfaSchema:namespaceURI>
                  <pdfaSchema:prefix>pdfx</pdfaSchema:prefix>
                  <pdfaSchema:schema>pdfx</pdfaSchema:schema>
                  <pdfaSchema:property>
                     <rdf:Seq>
                        <rdf:li rdf:parseType="Resource">
                           <pdfaProperty:category>internal</pdfaProperty:category>
                           <pdfaProperty:description>ID of PDF/X standard</pdfaProperty:description>
                           <pdfaProperty:name>GTS_PDFXVersion</pdfaProperty:name>
                           <pdfaProperty:valueType>Text</pdfaProperty:valueType>
                        </rdf:li>
                        <rdf:li rdf:parseType="Resource">
                           <pdfaProperty:category>internal</pdfaProperty:category>
                           <pdfaProperty:description>Conformance level of PDF/X standard</pdfaProperty:description>
                           <pdfaProperty:name>GTS_PDFXConformance</pdfaProperty:name>
                           <pdfaProperty:valueType>Text</pdfaProperty:valueType>
                        </rdf:li>
                        <rdf:li rdf:parseType="Resource">
                           <pdfaProperty:category>internal</pdfaProperty:category>
                           <pdfaProperty:description>Company creating the PDF</pdfaProperty:description>
                           <pdfaProperty:name>Company</pdfaProperty:name>
                           <pdfaProperty:valueType>Text</pdfaProperty:valueType>
                        </rdf:li>
                        <rdf:li rdf:parseType="Resource">
                           <pdfaProperty:category>internal</pdfaProperty:category>
                           <pdfaProperty:description>Date when document was last modified</pdfaProperty:description>
                           <pdfaProperty:name>SourceModified</pdfaProperty:name>
                           <pdfaProperty:valueType>Text</pdfaProperty:valueType>
                        </rdf:li>
                        <rdf:li rdf:parseType="Resource">
                           <pdfaProperty:category>external</pdfaProperty:category>
                           <pdfaProperty:description>Mirrors crossmark:CrosMarkDomains</pdfaProperty:description>
                           <pdfaProperty:name>CrossMarkDomains</pdfaProperty:name>
                           <pdfaProperty:valueType>Seq Text</pdfaProperty:valueType>
                        </rdf:li>
                        <rdf:li rdf:parseType="Resource">
                           <pdfaProperty:category>internal</pdfaProperty:category>
                           <pdfaProperty:description>Mirrors crossmark:DOI</pdfaProperty:description>
                           <pdfaProperty:name>doi</pdfaProperty:name>
                           <pdfaProperty:valueType>Text</pdfaProperty:valueType>
                        </rdf:li>
                     </rdf:Seq>
                  </pdfaSchema:property>
               </rdf:li>
               <rdf:li rdf:parseType="Resource">
                  <pdfaSchema:namespaceURI>http://ns.adobe.com/xap/1.0/mm/</pdfaSchema:namespaceURI>
                  <pdfaSchema:prefix>xmpMM</pdfaSchema:prefix>
                  <pdfaSchema:schema>XMP Media Management Schema</pdfaSchema:schema>
                  <pdfaSchema:property>
                     <rdf:Seq>
                        <rdf:li rdf:parseType="Resource">
                           <pdfaProperty:category>internal</pdfaProperty:category>
                           <pdfaProperty:description>UUID based identifier for specific incarnation of a document</pdfaProperty:description>
                           <pdfaProperty:name>InstanceID</pdfaProperty:name>
                           <pdfaProperty:valueType>URI</pdfaProperty:valueType>
                        </rdf:li>
                        <rdf:li rdf:parseType="Resource">
                           <pdfaProperty:category>internal</pdfaProperty:category>
                           <pdfaProperty:description>The common identifier for all versions and renditions of a document.</pdfaProperty:description>
                           <pdfaProperty:name>OriginalDocumentID</pdfaProperty:name>
                           <pdfaProperty:valueType>URI</pdfaProperty:valueType>
                        </rdf:li>
                     </rdf:Seq>
                  </pdfaSchema:property>
               </rdf:li>
               <rdf:li rdf:parseType="Resource">
                  <pdfaSchema:namespaceURI>http://www.aiim.org/pdfa/ns/id/</pdfaSchema:namespaceURI>
                  <pdfaSchema:prefix>pdfaid</pdfaSchema:prefix>
                  <pdfaSchema:schema>PDF/A ID Schema</pdfaSchema:schema>
                  <pdfaSchema:property>
                     <rdf:Seq>
                        <rdf:li rdf:parseType="Resource">
                           <pdfaProperty:category>internal</pdfaProperty:category>
                           <pdfaProperty:description>Part of PDF/A standard</pdfaProperty:description>
                           <pdfaProperty:name>part</pdfaProperty:name>
                           <pdfaProperty:valueType>Integer</pdfaProperty:valueType>
                        </rdf:li>
                        <rdf:li rdf:parseType="Resource">
                           <pdfaProperty:category>internal</pdfaProperty:category>
                           <pdfaProperty:description>Amendment of PDF/A standard</pdfaProperty:description>
                           <pdfaProperty:name>amd</pdfaProperty:name>
                           <pdfaProperty:valueType>Text</pdfaProperty:valueType>
                        </rdf:li>
                        <rdf:li rdf:parseType="Resource">
                           <pdfaProperty:category>internal</pdfaProperty:category>
                           <pdfaProperty:description>Conformance level of PDF/A standard</pdfaProperty:description>
                           <pdfaProperty:name>conformance</pdfaProperty:name>
                           <pdfaProperty:valueType>Text</pdfaProperty:valueType>
                        </rdf:li>
                     </rdf:Seq>
                  </pdfaSchema:property>
               </rdf:li>
               <rdf:li rdf:parseType="Resource">
                  <pdfaSchema:namespaceURI>http://crossref.org/crossmark/1.0/</pdfaSchema:namespaceURI>
                  <pdfaSchema:prefix>crossmark</pdfaSchema:prefix>
                  <pdfaSchema:schema>crossmark</pdfaSchema:schema>
                  <pdfaSchema:property>
                     <rdf:Seq>
                        <rdf:li rdf:parseType="Resource">
                           <pdfaProperty:category>internal</pdfaProperty:category>
                           <pdfaProperty:description>CrossMarkDomains</pdfaProperty:description>
                           <pdfaProperty:name>CrossMarkDomains</pdfaProperty:name>
                           <pdfaProperty:valueType>Seq Text</pdfaProperty:valueType>
                        </rdf:li>
                        <rdf:li rdf:parseType="Resource">
                           <pdfaProperty:category>internal</pdfaProperty:category>
                           <pdfaProperty:description>CrossmarkDomainExclusive</pdfaProperty:description>
                           <pdfaProperty:name>CrossmarkDomainExclusive</pdfaProperty:name>
                           <pdfaProperty:valueType>Text</pdfaProperty:valueType>
                        </rdf:li>
                        <rdf:li rdf:parseType="Resource">
                           <pdfaProperty:category>internal</pdfaProperty:category>
                           <pdfaProperty:description>Usual same as prism:doi</pdfaProperty:description>
                           <pdfaProperty:name>DOI</pdfaProperty:name>
                           <pdfaProperty:valueType>Text</pdfaProperty:valueType>
                        </rdf:li>
                        <rdf:li rdf:parseType="Resource">
                           <pdfaProperty:category>external</pdfaProperty:category>
                           <pdfaProperty:description>The date when a publication was published.</pdfaProperty:description>
                           <pdfaProperty:name>MajorVersionDate</pdfaProperty:name>
                           <pdfaProperty:valueType>Text</pdfaProperty:valueType>
                        </rdf:li>
                     </rdf:Seq>
                  </pdfaSchema:property>
               </rdf:li>
               <rdf:li rdf:parseType="Resource">
                  <pdfaSchema:namespaceURI>http://prismstandard.org/namespaces/basic/2.0/</pdfaSchema:namespaceURI>
                  <pdfaSchema:prefix>prism</pdfaSchema:prefix>
                  <pdfaSchema:schema>Prism</pdfaSchema:schema>
                  <pdfaSchema:property>
                     <rdf:Seq>
                        <rdf:li rdf:parseType="Resource">
                           <pdfaProperty:category>external</pdfaProperty:category>
                           <pdfaProperty:description>The aggregation type specifies the unit of aggregation for a content collection. &#xA;Comment &#xA;PRISM recommends that the PRISM Aggregation Type Controlled Vocabulary be used to provide values for this element. &#xA;Note: PRISM recommends against the use of the #other value currently allowed in this controlled vocabulary. In lieu of using #other please reach out to the PRISM group at info@prismstandard.org to request addition of your term to the Aggregation Type Controlled Vocabulary. &#xA;&#xA;</pdfaProperty:description>
                           <pdfaProperty:name>aggregationType</pdfaProperty:name>
                           <pdfaProperty:valueType>Text</pdfaProperty:valueType>
                        </rdf:li>
                        <rdf:li rdf:parseType="Resource">
                           <pdfaProperty:category>external</pdfaProperty:category>
                           <pdfaProperty:description>Copyright </pdfaProperty:description>
                           <pdfaProperty:name>copyright</pdfaProperty:name>
                           <pdfaProperty:valueType>Text</pdfaProperty:valueType>
                        </rdf:li>
                        <rdf:li rdf:parseType="Resource">
                           <pdfaProperty:category>external</pdfaProperty:category>
                           <pdfaProperty:description>The Digital Object Identifier for the article.&#xA;The DOI may also be used as the dc:identifier. If used as a dc:identifier, the URI form should be captured, and the bare identifier should also be captured using prism:doi. If an alternate unique identifier is used as the required dc:identifier, then the DOI should be specified as a bare identifier within prism:doi only. &#xA;If the URL associated with a DOI is to be specified, then prism:url may be used in conjunction with prism:doi in order to provide the service endpoint (i.e. the URL). &#xA;</pdfaProperty:description>
                           <pdfaProperty:name>doi</pdfaProperty:name>
                           <pdfaProperty:valueType>Text</pdfaProperty:valueType>
                        </rdf:li>
                        <rdf:li rdf:parseType="Resource">
                           <pdfaProperty:category>external</pdfaProperty:category>
                           <pdfaProperty:description>ISSN for an electronic version of the issue in which the resource occurs. &#xA;Permits publishers to include a second ISSN, identifying an electronic version of the issue in which the resource occurs (therefore e(lectronic)Issn. If used, prism:eIssn MUST contain the ISSN of the electronic version. See prism:issn. &#xA;</pdfaProperty:description>
                           <pdfaProperty:name>issn</pdfaProperty:name>
                           <pdfaProperty:valueType>Text</pdfaProperty:valueType>
                        </rdf:li>
                        <rdf:li rdf:parseType="Resource">
                           <pdfaProperty:category>external</pdfaProperty:category>
                           <pdfaProperty:description>Title of the magazine, or other publication, in which a resource was/will be published. &#xA;Typically this will be used to provide the name of the magazine an article appeared in as metadata for the article, along with information such as the article title, the publisher, volume, number, and cover date. &#xA;&#xA;Note: Publication name can be used to differentiate between a print magazine and the online version if the names are different such as “magazine” and “magazine.com.” &#xA;</pdfaProperty:description>
                           <pdfaProperty:name>publicationName</pdfaProperty:name>
                           <pdfaProperty:valueType>Text</pdfaProperty:valueType>
                        </rdf:li>
                        <rdf:li rdf:parseType="Resource">
                           <pdfaProperty:category>external</pdfaProperty:category>
                           <pdfaProperty:description>This element provides the url for an article or unit of content. &#xA;The attribute platform is optionally allowed for situations in which multiple URLs must be specified. PRISM recommends that a subset of the PCV platform values, namely “mobile” and “web”, be used in conjunction with this element. &#xA;NOTE: PRISM recommends against the use of the #other value allowed in the PRISM Platform controlled vocabulary. In lieu of using #other please reach out to the PRISM group at prism-wg@yahoogroups.com to request addition of your term to the Platform Controlled Vocabulary. &#xA;</pdfaProperty:description>
                           <pdfaProperty:name>url</pdfaProperty:name>
                           <pdfaProperty:valueType>Text</pdfaProperty:valueType>
                        </rdf:li>
                     </rdf:Seq>
                  </pdfaSchema:property>
               </rdf:li>
               <rdf:li rdf:parseType="Resource">
                  <pdfaSchema:namespaceURI>http://springernature.com/ns/xmpExtensions/2.0/</pdfaSchema:namespaceURI>
                  <pdfaSchema:prefix>sn</pdfaSchema:prefix>
                  <pdfaSchema:schema>Springer Nature ORCID Schema</pdfaSchema:schema>
                  <pdfaSchema:property>
                     <rdf:Seq>
                        <rdf:li rdf:parseType="Resource">
                           <pdfaProperty:category>external</pdfaProperty:category>
                           <pdfaProperty:description>Author information: contains the name of each author and his/her ORCID (ORCiD: Open Researcher and Contributor ID). An ORCID is a persistent identifier (a non-proprietary alphanumeric code) to uniquely identify scientific and other academic authors.</pdfaProperty:description>
                           <pdfaProperty:name>authorInfo</pdfaProperty:name>
                           <pdfaProperty:valueType>Bag AuthorInformation</pdfaProperty:valueType>
                        </rdf:li>
                     </rdf:Seq>
                  </pdfaSchema:property>
                  <pdfaSchema:valueType>
                     <rdf:Seq>
                        <rdf:li rdf:parseType="Resource">
                           <pdfaType:description>Specifies the types of author information: name and ORCID of an author.</pdfaType:description>
                           <pdfaType:namespaceURI>http://springernature.com/ns/xmpExtensions/2.0/authorInfo/</pdfaType:namespaceURI>
                           <pdfaType:prefix>author</pdfaType:prefix>
                           <pdfaType:type>AuthorInformation</pdfaType:type>
                           <pdfaType:field>
                              <rdf:Seq>
                                 <rdf:li rdf:parseType="Resource">
                                    <pdfaField:description>Gives the name of an author.</pdfaField:description>
                                    <pdfaField:name>name</pdfaField:name>
                                    <pdfaField:valueType>Text</pdfaField:valueType>
                                 </rdf:li>
                                 <rdf:li rdf:parseType="Resource">
                                    <pdfaField:description>Gives the ORCID of an author.</pdfaField:description>
                                    <pdfaField:name>orcid</pdfaField:name>
                                    <pdfaField:valueType>URI</pdfaField:valueType>
                                 </rdf:li>
                              </rdf:Seq>
                           </pdfaType:field>
                        </rdf:li>
                     </rdf:Seq>
                  </pdfaSchema:valueType>
               </rdf:li>
               <rdf:li rdf:parseType="Resource">
                  <pdfaSchema:namespaceURI>http://www.niso.org/schemas/jav/1.0/</pdfaSchema:namespaceURI>
                  <pdfaSchema:prefix>jav</pdfaSchema:prefix>
                  <pdfaSchema:schema>NISO</pdfaSchema:schema>
                  <pdfaSchema:property>
                     <rdf:Seq>
                        <rdf:li rdf:parseType="Resource">
                           <pdfaProperty:category>external</pdfaProperty:category>
                           <pdfaProperty:description>Values for Journal Article Version are one of the following:&#xA;AO = Author’s Original&#xA;SMUR = Submitted Manuscript Under Review&#xA;AM = Accepted Manuscript&#xA;P = Proof&#xA;VoR = Version of Record&#xA;CVoR = Corrected Version of Record&#xA;EVoR = Enhanced Version of Record</pdfaProperty:description>
                           <pdfaProperty:name>journal_article_version</pdfaProperty:name>
                           <pdfaProperty:valueType>Closed Choice of Text</pdfaProperty:valueType>
                        </rdf:li>
                     </rdf:Seq>
                  </pdfaSchema:property>
               </rdf:li>
            </rdf:Bag>
         </pdfaExtension:schemas>
      </rdf:Description>
   </rdf:RDF>
</x:xmpmeta>
   Pages: 
    Page: 
     Label: 1
     Annotations: 
      Annotation: 
       Subtype: Link
       Rect: 134, 539, 135, 550
       Flags: Print
       AppearanceDictionary: true
      Annotation: 
       Subtype: Link
       Rect: 134, 539, 135, 550
       Flags: Print
       AppearanceDictionary: true
      Annotation: 
       Subtype: Link
       Rect: 143, 539, 144, 550
       Flags: Print
       AppearanceDictionary: true
      Annotation: 
       Subtype: Link
       Rect: 133, 539, 144, 550
       Flags: Print
       AppearanceDictionary: true
      Annotation: 
       Subtype: Link
       Rect: 144, 539, 147, 550
       Flags: Print
       AppearanceDictionary: true
      Annotation: 
       Subtype: Link
       Rect: 251, 539, 252, 550
       Flags: Print
       AppearanceDictionary: true
      Annotation: 
       Subtype: Link
       Rect: 251, 539, 252, 550
       Flags: Print
       AppearanceDictionary: true
      Annotation: 
       Subtype: Link
       Rect: 260, 539, 261, 550
       Flags: Print
       AppearanceDictionary: true
      Annotation: 
       Subtype: Link
       Rect: 250, 539, 261, 550
       Flags: Print
       AppearanceDictionary: true
      Annotation: 
       Subtype: Link
       Rect: 261, 539, 264, 550
       Flags: Print
       AppearanceDictionary: true
      Annotation: 
       Subtype: Link
       Rect: 382, 539, 383, 550
       Flags: Print
       AppearanceDictionary: true
      Annotation: 
       Subtype: Link
       Rect: 382, 539, 383, 550
       Flags: Print
       AppearanceDictionary: true
      Annotation: 
       Subtype: Link
       Rect: 391, 539, 392, 550
       Flags: Print
       AppearanceDictionary: true
      Annotation: 
       Subtype: Link
       Rect: 381, 539, 392, 550
       Flags: Print
       AppearanceDictionary: true
      Annotation: 
       Subtype: Link
       Rect: 392, 539, 395, 550
       Flags: Print
       AppearanceDictionary: true
      Annotation: 
       Subtype: Link
       Rect: 105, 523, 106, 534
       Flags: Print
       AppearanceDictionary: true
      Annotation: 
       Subtype: Link
       Rect: 105, 523, 106, 534
       Flags: Print
       AppearanceDictionary: true
      Annotation: 
       Subtype: Link
       Rect: 114, 523, 115, 534
       Flags: Print
       AppearanceDictionary: true
      Annotation: 
       Subtype: Link
       Rect: 104, 523, 115, 534
       Flags: Print
       AppearanceDictionary: true
      Annotation: 
       Subtype: Link
       Rect: 115, 523, 117, 534
       Flags: Print
       AppearanceDictionary: true
      Annotation: 
       Subtype: Link
       Rect: 310, 523, 311, 534
       Flags: Print
       AppearanceDictionary: true
      Annotation: 
       Subtype: Link
       Rect: 310, 523, 311, 534
       Flags: Print
       AppearanceDictionary: true
      Annotation: 
       Subtype: Link
       Rect: 319, 523, 320, 534
       Flags: Print
       AppearanceDictionary: true
      Annotation: 
       Subtype: Link
       Rect: 309, 523, 320, 534
       Flags: Print
       AppearanceDictionary: true
      Annotation: 
       Subtype: Link
       Rect: 320, 523, 322, 534
       Flags: Print
       AppearanceDictionary: true
      Annotation: 
       Subtype: Link
       Rect: 391, 523, 392, 534
       Flags: Print
       AppearanceDictionary: true
      Annotation: 
       Subtype: Link
       Rect: 391, 523, 392, 534
       Flags: Print
       AppearanceDictionary: true
      Annotation: 
       Subtype: Link
       Rect: 400, 523, 401, 534
       Flags: Print
       AppearanceDictionary: true
      Annotation: 
       Subtype: Link
       Rect: 390, 523, 401, 534
       Flags: Print
       AppearanceDictionary: true
      Annotation: 
       Subtype: Link
       Rect: 401, 523, 404, 534
       Flags: Print
       AppearanceDictionary: true
      Annotation: 
       Subtype: Link
       Rect: 482, 523, 483, 534
       Flags: Print
       AppearanceDictionary: true
      Annotation: 
       Subtype: Link
       Rect: 482, 523, 483, 534
       Flags: Print
       AppearanceDictionary: true
      Annotation: 
       Subtype: Link
       Rect: 491, 523, 492, 534
       Flags: Print
       AppearanceDictionary: true
      Annotation: 
       Subtype: Link
       Rect: 481, 523, 492, 534
       Flags: Print
       AppearanceDictionary: true
      Annotation: 
       Subtype: Link
       Rect: 492, 523, 495, 534
       Flags: Print
       AppearanceDictionary: true
      Annotation: 
       Subtype: Link
       Rect: 111, 507, 112, 518
       Flags: Print
       AppearanceDictionary: true
      Annotation: 
       Subtype: Link
       Rect: 111, 507, 112, 518
       Flags: Print
       AppearanceDictionary: true
      Annotation: 
       Subtype: Link
       Rect: 120, 507, 121, 518
       Flags: Print
       AppearanceDictionary: true
      Annotation: 
       Subtype: Link
       Rect: 110, 507, 121, 518
       Flags: Print
       AppearanceDictionary: true
      Annotation: 
       Subtype: Link
       Rect: 121, 507, 124, 518
       Flags: Print
       AppearanceDictionary: true
      Annotation: 
       Subtype: Link
       Rect: 202, 507, 203, 518
       Flags: Print
       AppearanceDictionary: true
      Annotation: 
       Subtype: Link
       Rect: 202, 507, 203, 518
       Flags: Print
       AppearanceDictionary: true
      Annotation: 
       Subtype: Link
       Rect: 211, 507, 212, 518
       Flags: Print
       AppearanceDictionary: true
      Annotation: 
       Subtype: Link
       Rect: 201, 507, 212, 518
       Flags: Print
       AppearanceDictionary: true
      Annotation: 
       Subtype: Link
       Rect: 212, 507, 214, 518
       Flags: Print
       AppearanceDictionary: true
      Annotation: 
       Subtype: Link
       Rect: 292, 507, 293, 518
       Flags: Print
       AppearanceDictionary: true
      Annotation: 
       Subtype: Link
       Rect: 292, 507, 293, 518
       Flags: Print
       AppearanceDictionary: true
      Annotation: 
       Subtype: Link
       Rect: 301, 507, 302, 518
       Flags: Print
       AppearanceDictionary: true
      Annotation: 
       Subtype: Link
       Rect: 291, 507, 302, 518
       Flags: Print
       AppearanceDictionary: true
      Annotation: 
       Subtype: Link
       Rect: 302, 507, 304, 518
       Flags: Print
       AppearanceDictionary: true
      Annotation: 
       Subtype: Link
       Rect: 388, 507, 389, 518
       Flags: Print
       AppearanceDictionary: true
      Annotation: 
       Subtype: Link
       Rect: 388, 507, 389, 518
       Flags: Print
       AppearanceDictionary: true
      Annotation: 
       Subtype: Link
       Rect: 397, 507, 398, 518
       Flags: Print
       AppearanceDictionary: true
      Annotation: 
       Subtype: Link
       Rect: 387, 507, 398, 518
       Flags: Print
       AppearanceDictionary: true
      Annotation: 
       Subtype: Link
       Rect: 398, 507, 400, 518
       Flags: Print
       AppearanceDictionary: true
      Annotation: 
       Subtype: Link
       Rect: 475, 507, 476, 518
       Flags: Print
       AppearanceDictionary: true
      Annotation: 
       Subtype: Link
       Rect: 475, 507, 476, 518
       Flags: Print
       AppearanceDictionary: true
      Annotation: 
       Subtype: Link
       Rect: 484, 507, 485, 518
       Flags: Print
       AppearanceDictionary: true
      Annotation: 
       Subtype: Link
       Rect: 474, 507, 485, 518
       Flags: Print
       AppearanceDictionary: true
      Annotation: 
       Subtype: Link
       Rect: 485, 507, 488, 518
       Flags: Print
       AppearanceDictionary: true
      Annotation: 
       Subtype: Link
       Rect: 93, 491, 94, 502
       Flags: Print
       AppearanceDictionary: true
      Annotation: 
       Subtype: Link
       Rect: 93, 491, 94, 502
       Flags: Print
       AppearanceDictionary: true
      Annotation: 
       Subtype: Link
       Rect: 102, 491, 103, 502
       Flags: Print
       AppearanceDictionary: true
      Annotation: 
       Subtype: Link
       Rect: 92, 491, 103, 502
       Flags: Print
       AppearanceDictionary: true
      Annotation: 
       Subtype: Link
       Rect: 103, 491, 106, 502
       Flags: Print
       AppearanceDictionary: true
      Annotation: 
       Subtype: Link
       Rect: 174, 491, 175, 502
       Flags: Print
       AppearanceDictionary: true
      Annotation: 
       Subtype: Link
       Rect: 174, 491, 175, 502
       Flags: Print
       AppearanceDictionary: true
      Annotation: 
       Subtype: Link
       Rect: 183, 491, 184, 502
       Flags: Print
       AppearanceDictionary: true
      Annotation: 
       Subtype: Link
       Rect: 173, 491, 184, 502
       Flags: Print
       AppearanceDictionary: true
      Annotation: 
       Subtype: Link
       Rect: 184, 491, 186, 502
       Flags: Print
       AppearanceDictionary: true
      Annotation: 
       Subtype: Link
       Rect: 265, 491, 266, 502
       Flags: Print
       AppearanceDictionary: true
      Annotation: 
       Subtype: Link
       Rect: 265, 491, 266, 502
       Flags: Print
       AppearanceDictionary: true
      Annotation: 
       Subtype: Link
       Rect: 273, 491, 274, 502
       Flags: Print
       AppearanceDictionary: true
      Annotation: 
       Subtype: Link
       Rect: 264, 491, 274, 502
       Flags: Print
       AppearanceDictionary: true
      Annotation: 
       Subtype: Link
       Rect: 274, 491, 277, 502
       Flags: Print
       AppearanceDictionary: true
      Annotation: 
       Subtype: Link
       Rect: 438, 491, 439, 502
       Flags: Print
       AppearanceDictionary: true
      Annotation: 
       Subtype: Link
       Rect: 438, 491, 439, 502
       Flags: Print
       AppearanceDictionary: true
      Annotation: 
       Subtype: Link
       Rect: 447, 491, 448, 502
       Flags: Print
       AppearanceDictionary: true
      Annotation: 
       Subtype: Link
       Rect: 437, 491, 448, 502
       Flags: Print
       AppearanceDictionary: true
      Annotation: 
       Subtype: Link
       Rect: 448, 491, 450, 502
       Flags: Print
       AppearanceDictionary: true
      Annotation: 
       Subtype: Link
       Rect: 536, 491, 537, 502
       Flags: Print
       AppearanceDictionary: true
      Annotation: 
       Subtype: Link
       Rect: 536, 491, 537, 502
       Flags: Print
       AppearanceDictionary: true
      Annotation: 
       Subtype: Link
       Rect: 544, 491, 545, 502
       Flags: Print
       AppearanceDictionary: true
      Annotation: 
       Subtype: Link
       Rect: 535, 491, 545, 502
       Flags: Print
       AppearanceDictionary: true
      Annotation: 
       Subtype: Link
       Rect: 545, 491, 548, 502
       Flags: Print
       AppearanceDictionary: true
      Annotation: 
       Subtype: Link
       Rect: 445, 43, 526, 51
       Flags: Print
       AppearanceDictionary: true
      Annotation: 
       Subtype: Link
       Rect: 370, 23, 485, 30
       Flags: Print
       AppearanceDictionary: true
      Annotation: 
       Subtype: Link
       Rect: 547, 23, 551, 30
       Flags: Print
       AppearanceDictionary: true
     Thumb: true
    Page: 
     Label: 2
     Annotations: 
      Annotation: 
       Subtype: Link
       Rect: 145, 694, 149, 702
       Flags: Print
       AppearanceDictionary: true
       Destination: 221
      Annotation: 
       Subtype: Link
       Rect: 150, 694, 154, 702
       Flags: Print
       AppearanceDictionary: true
       Destination: 221
      Annotation: 
       Subtype: Link
       Rect: 192, 610, 196, 618
       Flags: Print
       AppearanceDictionary: true
       Destination: null
      Annotation: 
       Subtype: Link
       Rect: 86, 558, 90, 566
       Flags: Print
       AppearanceDictionary: true
       Destination: 221
      Annotation: 
       Subtype: Link
       Rect: 91, 558, 95, 566
       Flags: Print
       AppearanceDictionary: true
       Destination: 221
      Annotation: 
       Subtype: Link
       Rect: 173, 485, 177, 493
       Flags: Print
       AppearanceDictionary: true
       Destination: 221
      Annotation: 
       Subtype: Link
       Rect: 181, 485, 184, 493
       Flags: Print
       AppearanceDictionary: true
       Destination: 221
      Annotation: 
       Subtype: Link
       Rect: 229, 401, 232, 409
       Flags: Print
       AppearanceDictionary: true
       Destination: 221
      Annotation: 
       Subtype: Link
       Rect: 236, 401, 243, 409
       Flags: Print
       AppearanceDictionary: true
       Destination: null
      Annotation: 
       Subtype: Link
       Rect: 270, 349, 278, 357
       Flags: Print
       AppearanceDictionary: true
       Destination: null
      Annotation: 
       Subtype: Link
       Rect: 214, 339, 221, 346
       Flags: Print
       AppearanceDictionary: true
       Destination: null
      Annotation: 
       Subtype: Link
       Rect: 223, 339, 230, 346
       Flags: Print
       AppearanceDictionary: true
       Destination: null
      Annotation: 
       Subtype: Link
       Rect: 274, 318, 278, 325
       Flags: Print
       AppearanceDictionary: true
       Destination: 221
      Annotation: 
       Subtype: Link
       Rect: 208, 286, 215, 294
       Flags: Print
       AppearanceDictionary: true
       Destination: null
      Annotation: 
       Subtype: Link
       Rect: 230, 265, 237, 273
       Flags: Print
       AppearanceDictionary: true
       Destination: null
      Annotation: 
       Subtype: Link
       Rect: 239, 265, 246, 273
       Flags: Print
       AppearanceDictionary: true
       Destination: null
      Annotation: 
       Subtype: Link
       Rect: 522, 670, 527, 679
       Flags: Print
       AppearanceDictionary: true
       Destination: 47
      Annotation: 
       Subtype: Link
       Rect: 360, 659, 365, 669
       Flags: Print
       AppearanceDictionary: true
       Destination: 47
      Annotation: 
       Subtype: Link
       Rect: 528, 663, 535, 670
       Flags: Print
       AppearanceDictionary: true
       Destination: null
      Annotation: 
       Subtype: Link
       Rect: 420, 534, 424, 543
       Flags: Print
       AppearanceDictionary: true
       Destination: 47
      Annotation: 
       Subtype: Link
       Rect: 447, 523, 451, 533
       Flags: Print
       AppearanceDictionary: true
       Destination: 47
      Annotation: 
       Subtype: Link
       Rect: 322, 408, 327, 418
       Flags: Print
       AppearanceDictionary: true
       Destination: 47
      Annotation: 
       Subtype: Link
       Rect: 511, 367, 515, 376
       Flags: Print
       AppearanceDictionary: true
       Destination: 47
      Annotation: 
       Subtype: Link
       Rect: 537, 325, 542, 334
       Flags: Print
       AppearanceDictionary: true
       Destination: 47
      Annotation: 
       Subtype: Link
       Rect: 325, 241, 329, 250
       Flags: Print
       AppearanceDictionary: true
       Destination: 47
      Annotation: 
       Subtype: Link
       Rect: 426, 115, 430, 125
       Flags: Print
       AppearanceDictionary: true
       Destination: 47
      Annotation: 
       Subtype: Link
       Rect: 436, 23, 551, 30
       Flags: Print
       AppearanceDictionary: true
     Thumb: true
    Page: 
     Label: 3
     Annotations: 
      Annotation: 
       Subtype: Link
       Rect: 161, 65, 165, 75
       Flags: Print
       AppearanceDictionary: true
       Destination: 47
      Annotation: 
       Subtype: Link
       Rect: 277, 55, 281, 64
       Flags: Print
       AppearanceDictionary: true
       Destination: 47
      Annotation: 
       Subtype: Link
       Rect: 370, 23, 485, 30
       Flags: Print
       AppearanceDictionary: true
      Annotation: 
       Subtype: Link
       Rect: 547, 23, 551, 30
       Flags: Print
       AppearanceDictionary: true
     Thumb: true
    Page: 
     Label: 4
     Annotations: 
      Annotation: 
       Subtype: Link
       Rect: 105, 427, 108, 434
       Flags: Print
       AppearanceDictionary: true
       Destination: 221
      Annotation: 
       Subtype: Link
       Rect: 108, 350, 112, 360
       Flags: Print
       AppearanceDictionary: true
       Destination: 71
      Annotation: 
       Subtype: Link
       Rect: 63, 308, 68, 318
       Flags: Print
       AppearanceDictionary: true
       Destination: 71
      Annotation: 
       Subtype: Link
       Rect: 64, 277, 68, 286
       Flags: Print
       AppearanceDictionary: true
       Destination: 71
      Annotation: 
       Subtype: Link
       Rect: 117, 119, 122, 128
       Flags: Print
       AppearanceDictionary: true
       Destination: 89
      Annotation: 
       Subtype: Link
       Rect: 148, 98, 153, 107
       Flags: Print
       AppearanceDictionary: true
       Destination: 89
      Annotation: 
       Subtype: Link
       Rect: 110, 45, 115, 55
       Flags: Print
       AppearanceDictionary: true
       Destination: 89
      Annotation: 
       Subtype: Link
       Rect: 515, 423, 520, 433
       Flags: Print
       AppearanceDictionary: true
       Destination: 109
      Annotation: 
       Subtype: Link
       Rect: 325, 361, 330, 370
       Flags: Print
       AppearanceDictionary: true
       Destination: 109
      Annotation: 
       Subtype: Link
       Rect: 540, 329, 544, 339
       Flags: Print
       AppearanceDictionary: true
       Destination: 109
      Annotation: 
       Subtype: Link
       Rect: 529, 280, 536, 288
       Flags: Print
       AppearanceDictionary: true
       Destination: null
      Annotation: 
       Subtype: Link
       Rect: 450, 239, 457, 246
       Flags: Print
       AppearanceDictionary: true
       Destination: null
      Annotation: 
       Subtype: Link
       Rect: 452, 183, 457, 192
       Flags: Print
       AppearanceDictionary: true
       Destination: 109
      Annotation: 
       Subtype: Link
       Rect: 398, 99, 403, 109
       Flags: Print
       AppearanceDictionary: true
       Destination: 109
      Annotation: 
       Subtype: Link
       Rect: 436, 23, 551, 30
       Flags: Print
       AppearanceDictionary: true
     Thumb: true
    Page: 
     Label: 5
     Annotations: 
      Annotation: 
       Subtype: Link
       Rect: 61, 140, 66, 149
       Flags: Print
       AppearanceDictionary: true
       Destination: 134
      Annotation: 
       Subtype: Link
       Rect: 111, 119, 115, 128
       Flags: Print
       AppearanceDictionary: true
       Destination: 134
      Annotation: 
       Subtype: Link
       Rect: 256, 98, 261, 108
       Flags: Print
       AppearanceDictionary: true
       Destination: 134
      Annotation: 
       Subtype: Link
       Rect: 212, 67, 217, 76
       Flags: Print
       AppearanceDictionary: true
       Destination: 134
      Annotation: 
       Subtype: Link
       Rect: 199, 46, 203, 55
       Flags: Print
       AppearanceDictionary: true
       Destination: 134
      Annotation: 
       Subtype: Link
       Rect: 345, 150, 350, 160
       Flags: Print
       AppearanceDictionary: true
       Destination: 134
      Annotation: 
       Subtype: Link
       Rect: 493, 140, 498, 149
       Flags: Print
       AppearanceDictionary: true
       Destination: 134
      Annotation: 
       Subtype: Link
       Rect: 447, 49, 454, 57
       Flags: Print
       AppearanceDictionary: true
       Destination: null
      Annotation: 
       Subtype: Link
       Rect: 370, 23, 485, 30
       Flags: Print
       AppearanceDictionary: true
      Annotation: 
       Subtype: Link
       Rect: 547, 23, 551, 30
       Flags: Print
       AppearanceDictionary: true
     Thumb: true
    Page: 
     Label: 6
     Annotations: 
      Annotation: 
       Subtype: Link
       Rect: 230, 369, 235, 378
       Flags: Print
       AppearanceDictionary: true
       Destination: 134
      Annotation: 
       Subtype: Link
       Rect: 185, 306, 190, 315
       Flags: Print
       AppearanceDictionary: true
       Destination: 134
      Annotation: 
       Subtype: Link
       Rect: 147, 182, 154, 189
       Flags: Print
       AppearanceDictionary: true
       Destination: null
      Annotation: 
       Subtype: Link
       Rect: 66, 115, 70, 125
       Flags: Print
       AppearanceDictionary: true
       Destination: 134
      Annotation: 
       Subtype: Link
       Rect: 203, 105, 208, 114
       Flags: Print
       AppearanceDictionary: true
       Destination: 134
      Annotation: 
       Subtype: Link
       Rect: 121, 67, 129, 74
       Flags: Print
       AppearanceDictionary: true
       Destination: null
      Annotation: 
       Subtype: Link
       Rect: 324, 410, 328, 420
       Flags: Print
       AppearanceDictionary: true
       Destination: 134
      Annotation: 
       Subtype: Link
       Rect: 429, 337, 433, 347
       Flags: Print
       AppearanceDictionary: true
       Destination: 134
      Annotation: 
       Subtype: Link
       Rect: 465, 316, 470, 326
       Flags: Print
       AppearanceDictionary: true
       Destination: 134
      Annotation: 
       Subtype: Link
       Rect: 331, 275, 336, 284
       Flags: Print
       AppearanceDictionary: true
       Destination: 134
      Annotation: 
       Subtype: Link
       Rect: 474, 126, 478, 135
       Flags: Print
       AppearanceDictionary: true
       Destination: 160
      Annotation: 
       Subtype: Link
       Rect: 340, 63, 345, 73
       Flags: Print
       AppearanceDictionary: true
       Destination: 160
      Annotation: 
       Subtype: Link
       Rect: 436, 23, 551, 30
       Flags: Print
       AppearanceDictionary: true
     Thumb: true
    Page: 
     Label: 7
     Annotations: 
      Annotation: 
       Subtype: Link
       Rect: 519, 181, 523, 190
       Flags: Print
       AppearanceDictionary: true
       Destination: 180
      Annotation: 
       Subtype: Link
       Rect: 470, 139, 474, 148
       Flags: Print
       AppearanceDictionary: true
       Destination: 180
      Annotation: 
       Subtype: Link
       Rect: 511, 118, 516, 127
       Flags: Print
       AppearanceDictionary: true
       Destination: 180
      Annotation: 
       Subtype: Link
       Rect: 365, 45, 370, 54
       Flags: Print
       AppearanceDictionary: true
       Destination: 180
      Annotation: 
       Subtype: Link
       Rect: 370, 23, 485, 30
       Flags: Print
       AppearanceDictionary: true
      Annotation: 
       Subtype: Link
       Rect: 547, 23, 551, 30
       Flags: Print
       AppearanceDictionary: true
     Thumb: true
    Page: 
     Label: 8
     Annotations: 
      Annotation: 
       Subtype: Link
       Rect: 436, 23, 551, 30
       Flags: Print
       AppearanceDictionary: true
     Thumb: true
    Page: 
     Label: 9
     Annotations: 
      Annotation: 
       Subtype: Link
       Rect: 207, 316, 211, 326
       Flags: Print
       AppearanceDictionary: true
       Destination: 180
      Annotation: 
       Subtype: Link
       Rect: 249, 285, 254, 294
       Flags: Print
       AppearanceDictionary: true
       Destination: 180
      Annotation: 
       Subtype: Link
       Rect: 102, 140, 109, 147
       Flags: Print
       AppearanceDictionary: true
       Destination: null
      Annotation: 
       Subtype: Link
       Rect: 111, 140, 118, 147
       Flags: Print
       AppearanceDictionary: true
       Destination: null
      Annotation: 
       Subtype: Link
       Rect: 485, 320, 492, 327
       Flags: Print
       AppearanceDictionary: true
       Destination: null
      Annotation: 
       Subtype: Link
       Rect: 490, 205, 497, 212
       Flags: Print
       AppearanceDictionary: true
       Destination: null
      Annotation: 
       Subtype: Link
       Rect: 499, 205, 506, 212
       Flags: Print
       AppearanceDictionary: true
       Destination: null
      Annotation: 
       Subtype: Link
       Rect: 524, 142, 528, 149
       Flags: Print
       AppearanceDictionary: true
       Destination: 221
      Annotation: 
       Subtype: Link
       Rect: 530, 142, 537, 149
       Flags: Print
       AppearanceDictionary: true
       Destination: null
      Annotation: 
       Subtype: Link
       Rect: 319, 100, 326, 108
       Flags: Print
       AppearanceDictionary: true
       Destination: null
      Annotation: 
       Subtype: Link
       Rect: 425, 69, 432, 76
       Flags: Print
       AppearanceDictionary: true
       Destination: null
      Annotation: 
       Subtype: Link
       Rect: 212, 425, 215, 433
       Flags: Print
       AppearanceDictionary: true
       Destination: 47
      Annotation: 
       Subtype: Link
       Rect: 516, 352, 521, 360
       Flags: Print
       AppearanceDictionary: true
       Destination: 134
      Annotation: 
       Subtype: Link
       Rect: 370, 23, 485, 30
       Flags: Print
       AppearanceDictionary: true
      Annotation: 
       Subtype: Link
       Rect: 547, 23, 551, 30
       Flags: Print
       AppearanceDictionary: true
     Thumb: true
    Page: 
     Label: 10
     Annotations: 
      Annotation: 
       Subtype: Link
       Rect: 220, 172, 227, 179
       Flags: Print
       AppearanceDictionary: true
       Destination: null
      Annotation: 
       Subtype: Link
       Rect: 228, 172, 236, 179
       Flags: Print
       AppearanceDictionary: true
       Destination: null
      Annotation: 
       Subtype: Link
       Rect: 229, 130, 233, 137
       Flags: Print
       AppearanceDictionary: true
       Destination: 221
      Annotation: 
       Subtype: Link
       Rect: 100, 98, 107, 106
       Flags: Print
       AppearanceDictionary: true
       Destination: null
      Annotation: 
       Subtype: Link
       Rect: 108, 98, 116, 106
       Flags: Print
       AppearanceDictionary: true
       Destination: null
      Annotation: 
       Subtype: Link
       Rect: 117, 98, 125, 106
       Flags: Print
       AppearanceDictionary: true
       Destination: null
      Annotation: 
       Subtype: Link
       Rect: 165, 98, 173, 106
       Flags: Print
       AppearanceDictionary: true
       Destination: null
      Annotation: 
       Subtype: Link
       Rect: 511, 243, 514, 251
       Flags: Print
       AppearanceDictionary: true
       Destination: 47
      Annotation: 
       Subtype: Link
       Rect: 436, 23, 551, 30
       Flags: Print
       AppearanceDictionary: true
     Thumb: true
    Page: 
     Label: 11
     Annotations: 
      Annotation: 
       Subtype: Link
       Rect: 370, 23, 485, 30
       Flags: Print
       AppearanceDictionary: true
      Annotation: 
       Subtype: Link
       Rect: 543, 23, 551, 30
       Flags: Print
       AppearanceDictionary: true
     Thumb: true
    Page: 
     Label: 12
     Annotations: 
      Annotation: 
       Subtype: Link
       Rect: 260, 680, 264, 690
       Flags: Print
       AppearanceDictionary: true
       Destination: 180
      Annotation: 
       Subtype: Link
       Rect: 210, 642, 217, 649
       Flags: Print
       AppearanceDictionary: true
       Destination: null
      Annotation: 
       Subtype: Link
       Rect: 58, 590, 65, 597
       Flags: Print
       AppearanceDictionary: true
       Destination: null
      Annotation: 
       Subtype: Link
       Rect: 68, 590, 76, 597
       Flags: Print
       AppearanceDictionary: true
       Destination: null
      Annotation: 
       Subtype: Link
       Rect: 108, 537, 115, 545
       Flags: Print
       AppearanceDictionary: true
       Destination: 232
      Annotation: 
       Subtype: Link
       Rect: 94, 412, 98, 419
       Flags: Print
       AppearanceDictionary: true
       Destination: 221
      Annotation: 
       Subtype: Link
       Rect: 100, 412, 107, 419
       Flags: Print
       AppearanceDictionary: true
       Destination: 232
      Annotation: 
       Subtype: Link
       Rect: 111, 412, 118, 419
       Flags: Print
       AppearanceDictionary: true
       Destination: null
      Annotation: 
       Subtype: Link
       Rect: 169, 318, 176, 325
       Flags: Print
       AppearanceDictionary: true
       Destination: null
      Annotation: 
       Subtype: Link
       Rect: 172, 297, 179, 304
       Flags: Print
       AppearanceDictionary: true
       Destination: null
      Annotation: 
       Subtype: Link
       Rect: 122, 244, 129, 252
       Flags: Print
       AppearanceDictionary: true
       Destination: null
      Annotation: 
       Subtype: Link
       Rect: 211, 223, 218, 231
       Flags: Print
       AppearanceDictionary: true
       Destination: null
      Annotation: 
       Subtype: Link
       Rect: 165, 161, 172, 168
       Flags: Print
       AppearanceDictionary: true
       Destination: null
      Annotation: 
       Subtype: Link
       Rect: 282, 87, 289, 95
       Flags: Print
       AppearanceDictionary: true
       Destination: null
      Annotation: 
       Subtype: Link
       Rect: 334, 279, 340, 285
       Flags: Print
       AppearanceDictionary: true
       Destination: null
      Annotation: 
       Subtype: Link
       Rect: 436, 23, 551, 30
       Flags: Print
       AppearanceDictionary: true
     Thumb: true
    Page: 
     Label: 13
     Annotations: 
      Annotation: 
       Subtype: Link
       Rect: 370, 23, 485, 30
       Flags: Print
       AppearanceDictionary: true
      Annotation: 
       Subtype: Link
       Rect: 543, 23, 551, 30
       Flags: Print
       AppearanceDictionary: true
     Thumb: true
    Page: 
     Label: 14
     Annotations: 
      Annotation: 
       Subtype: Link
       Rect: 436, 23, 551, 30
       Flags: Print
       AppearanceDictionary: true
     Thumb: true
    Page: 
     Label: 15
     Annotations: 
      Annotation: 
       Subtype: Link
       Rect: 463, 584, 551, 591
       Flags: Print
       AppearanceDictionary: true
      Annotation: 
       Subtype: Link
       Rect: 303, 575, 338, 582
       Flags: Print
       AppearanceDictionary: true
      Annotation: 
       Subtype: Link
       Rect: 475, 523, 538, 530
       Flags: Print
       AppearanceDictionary: true
      Annotation: 
       Subtype: Link
       Rect: 303, 514, 371, 521
       Flags: Print
       AppearanceDictionary: true
      Annotation: 
       Subtype: Link
       Rect: 472, 352, 551, 359
       Flags: Print
       AppearanceDictionary: true
      Annotation: 
       Subtype: Link
       Rect: 303, 343, 346, 350
       Flags: Print
       AppearanceDictionary: true
      Annotation: 
       Subtype: Link
       Rect: 370, 23, 485, 30
       Flags: Print
       AppearanceDictionary: true
      Annotation: 
       Subtype: Link
       Rect: 543, 23, 551, 30
       Flags: Print
       AppearanceDictionary: true
     Thumb: true
  Checksum: cc110454
   Type: CRC32
  Checksum: a6bd850e390af4532550068b865af736
   Type: MD5
  Checksum: 5b6387d6ad0e0a72d5eafb712ec954e4508e9ad6
   Type: SHA-1