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PageLayout: SinglePage PageMode: UseOutlines Language: EN Outlines: Item: Title: Defective HNF4alpha-dependent gene expression as a driver of hepatocellular failure in alcoholic hepatitis Destination: edu.harvard.hul.ois.jhove.module.pdf.PdfSimpleObject@11758f2a Children: Item: Title: Results and discussion Destination: edu.harvard.hul.ois.jhove.module.pdf.PdfSimpleObject@e720b71 Children: Item: Title: Patients with AH undergo deep transcriptional reprogramming Destination: edu.harvard.hul.ois.jhove.module.pdf.PdfSimpleObject@1b26f7b2 Item: Title: Fetal P2-dependent HNF4α isoforms are increased in AH Destination: edu.harvard.hul.ois.jhove.module.pdf.PdfSimpleObject@491cc5c9 Item: Title: Knockdown of HNF4α-P2 ameliorates HNF4α-P1 expression Destination: edu.harvard.hul.ois.jhove.module.pdf.PdfSimpleObject@74ad1f1f Item: Title: TGFB1 mediates HNF4α dysregulation Destination: edu.harvard.hul.ois.jhove.module.pdf.PdfSimpleObject@6a1aab78 Item: Title: miR122 is downregulated in patients with AH Destination: edu.harvard.hul.ois.jhove.module.pdf.PdfSimpleObject@462d5aee Item: Title: HNF4α-dependent genes are hypermethylated in AH patients Destination: edu.harvard.hul.ois.jhove.module.pdf.PdfSimpleObject@69b0fd6f Item: Title: AH patients show repressive chromatin in HNF4α targets Destination: edu.harvard.hul.ois.jhove.module.pdf.PdfSimpleObject@757942a1 Item: Title: Methods Destination: edu.harvard.hul.ois.jhove.module.pdf.PdfSimpleObject@4a87761d Children: Item: Title: Patients Destination: edu.harvard.hul.ois.jhove.module.pdf.PdfSimpleObject@66d1af89 Item: Title: RNA extraction, sequencing and bioinformatic analysis Destination: edu.harvard.hul.ois.jhove.module.pdf.PdfSimpleObject@8646db9 Item: Title: HNF4α gene splicing analysis Destination: edu.harvard.hul.ois.jhove.module.pdf.PdfSimpleObject@37374a5e Item: Title: Genomic DNA methylome analysis Destination: edu.harvard.hul.ois.jhove.module.pdf.PdfSimpleObject@4671e53b Item: Title: Chromatin immunoprecipitation-PCR (ChIP-PCR) Destination: edu.harvard.hul.ois.jhove.module.pdf.PdfSimpleObject@2db7a79b Item: Title: ChIP-seq of Histone marks Destination: edu.harvard.hul.ois.jhove.module.pdf.PdfSimpleObject@6950e31 Item: Title: Human primary hepatocytes and cell lines Destination: edu.harvard.hul.ois.jhove.module.pdf.PdfSimpleObject@b7dd107 Item: Title: RNA extraction and Real Time Polymerase Chain Reaction Destination: edu.harvard.hul.ois.jhove.module.pdf.PdfSimpleObject@42eca56e Item: Title: Protein extraction and Western Blot Destination: edu.harvard.hul.ois.jhove.module.pdf.PdfSimpleObject@52f759d7 Item: Title: Silencing of HNF4α isoforms P1 and P2 and of SMAD4 Destination: edu.harvard.hul.ois.jhove.module.pdf.PdfSimpleObject@7cbd213e Item: Title: Overexpression of HNF4α isoforms P1 and P2 Destination: edu.harvard.hul.ois.jhove.module.pdf.PdfSimpleObject@192d3247 Item: Title: Cell culture treatments Destination: edu.harvard.hul.ois.jhove.module.pdf.PdfSimpleObject@3ecd23d9 Item: Title: Biliary acid quantification Destination: edu.harvard.hul.ois.jhove.module.pdf.PdfSimpleObject@569cfc36 Item: Title: Glucose production assay Destination: edu.harvard.hul.ois.jhove.module.pdf.PdfSimpleObject@43bd930a Item: Title: Model of alcoholic liver disease Destination: edu.harvard.hul.ois.jhove.module.pdf.PdfSimpleObject@33723e30 Item: Title: Liver histopathological evaluation Destination: edu.harvard.hul.ois.jhove.module.pdf.PdfSimpleObject@64f6106c Item: Title: Immunohistochemistry Destination: edu.harvard.hul.ois.jhove.module.pdf.PdfSimpleObject@553a3d88 Item: Title: Single nucleotide polymorphism (SNP) cohorts Destination: edu.harvard.hul.ois.jhove.module.pdf.PdfSimpleObject@7a30d1e6 Item: Title: SNP analysis Destination: edu.harvard.hul.ois.jhove.module.pdf.PdfSimpleObject@5891e32e Item: Title: Mass Spectrometry of plasma samples for proteomic analysis (LC–nobreakMS/MS) Destination: edu.harvard.hul.ois.jhove.module.pdf.PdfSimpleObject@cb0ed20 Item: Title: References Destination: edu.harvard.hul.ois.jhove.module.pdf.PdfSimpleObject@8e24743 Item: Title: References Destination: edu.harvard.hul.ois.jhove.module.pdf.PdfSimpleObject@74a10858 Item: Title: Acknowledgements Destination: edu.harvard.hul.ois.jhove.module.pdf.PdfSimpleObject@23fe1d71 Item: Title: Author contributions Destination: edu.harvard.hul.ois.jhove.module.pdf.PdfSimpleObject@28ac3dc3 Item: Title: Competing interests Destination: edu.harvard.hul.ois.jhove.module.pdf.PdfSimpleObject@32eebfca Item: Title: ACKNOWLEDGEMENTS Destination: edu.harvard.hul.ois.jhove.module.pdf.PdfSimpleObject@4e718207 Info: Title: Defective HNF4alpha-dependent gene expression as a driver of hepatocellular failure in alcoholic hepatitis Author: Josepmaria Argemi Subject: Nature Communications, doi:10.1038/s41467-019-11004-3 Keywords: Creator: Springer Producer: iText® 5.3.5 ©2000-2012 1T3XT BVBA (AGPL-version) CreationDate: Tue Jul 09 21:29:59 CEST 2019 ModDate: Tue Jul 27 11:28:11 CEST 2021 ID: 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doi:10.1038/s41467-019-11004-3 Defective HNF4alpha-dependent gene expression as a driver of hepatocellular failure in alcoholic hepatitis Josepmaria Argemi Maria U. Latasa Stephen R. Atkinson Ilya O. Blokhin Veronica Massey Joel P. Gue Joaquin Cabezas Juan J. Lozano Derek Van Booven Aaron Bell Sheng Cao Lawrence A. Vernetti Juan P. Arab Meritxell Ventura-Cots Lia R. Edmunds Constantino Fondevilla Peter Stärkel Laurent Dubuquoy Alexandre Louvet Gemma Odena Juan L. Gomez Tomas Aragon Jose Altamirano Juan Caballeria Michael J. Jurczak D. Lansing Taylor Carmen Berasain Claes Wahlestedt Satdarshan P. Monga Marsha Y. Morgan Pau Sancho-Bru Philippe Mathurin Shinji Furuya Carolin Lackner Ivan Rusyn Vijay H. Shah Mark R. Thursz Jelena Mann Matias A. Avila Ramon Bataller Springer US Nature Communications, doi:10.1038/s41467-019-11004-3 10.1038/s41467-019-11004-3 http://dx.doi.org/10.1038/s41467-019-11004-3 journal Nature Communications © 2019, The Author(s) 2041-1723 10.1038/s41467-019-11004-3 springer.com springerlink.com 2010-04-23 True 10.1038/s41467-019-11004-3 springer.com springerlink.com Springer 2021-07-27T11:28:11+02:00 2019-07-10T00:29:59+05:30 2021-07-27T11:28:11+02:00 True iText® 5.3.5 ©2000-2012 1T3XT BVBA (AGPL-version) VoR uuid:76e859b7-0bd4-481f-a5be-28dcc36c0ee8 uuid:19786172-b370-49f9-932d-9d42b2c3de68 default 1 converted uuid:5909e4bd-f52e-45b2-bf6b-6d11c858b9d8 converted to PDF/A-2b pdfToolbox 2019-07-10T00:30:52+05:30 2 B Josepmaria Argemi http://orcid.org/0000-0003-1696-7753 Maria U. Latasa http://orcid.org/0000-0002-0878-1337 Joaquin Cabezas http://orcid.org/0000-0003-0012-484X Aaron Bell http://orcid.org/0000-0001-6648-0834 Juan P. Arab http://orcid.org/0000-0002-8561-396X Meritxell Ventura-Cots http://orcid.org/0000-0001-9513-2855 Peter Stärkel http://orcid.org/0000-0003-2938-4442 Laurent Dubuquoy http://orcid.org/0000-0003-3596-5497 Michael J. Jurczak http://orcid.org/0000-0002-6335-6915 Carmen Berasain http://orcid.org/0000-0001-7075-2476 Claes Wahlestedt http://orcid.org/0000-0003-4471-5916 Satdarshan P. Monga http://orcid.org/0000-0002-8437-3378 Pau Sancho-Bru http://orcid.org/0000-0001-5569-9259 Ramon Bataller http://orcid.org/0000-0001-6570-3557 http://ns.adobe.com/pdf/1.3/ pdf Adobe PDF Schema internal A name object indicating whether the document has been modified to include trapping information Trapped Text http://ns.adobe.com/pdfx/1.3/ pdfx pdfx internal ID of PDF/X standard GTS_PDFXVersion Text internal Conformance level of PDF/X standard GTS_PDFXConformance Text internal Company creating the PDF Company Text internal Date when document was last modified SourceModified Text external Mirrors crossmark:CrosMarkDomains CrossMarkDomains Seq Text internal Mirrors crossmark:DOI doi Text http://ns.adobe.com/xap/1.0/mm/ xmpMM XMP Media Management Schema internal UUID based identifier for specific incarnation of a document InstanceID URI internal The common identifier for all versions and renditions of a document. OriginalDocumentID URI http://www.aiim.org/pdfa/ns/id/ pdfaid PDF/A ID Schema internal Part of PDF/A standard part Integer internal Amendment of PDF/A standard amd Text internal Conformance level of PDF/A standard conformance Text http://crossref.org/crossmark/1.0/ crossmark crossmark internal CrossMarkDomains CrossMarkDomains Seq Text internal CrossmarkDomainExclusive CrossmarkDomainExclusive Text internal Usual same as prism:doi DOI Text external The date when a publication was published. MajorVersionDate Text http://prismstandard.org/namespaces/basic/2.0/ prism Prism external The aggregation type specifies the unit of aggregation for a content collection. Comment PRISM recommends that the PRISM Aggregation Type Controlled Vocabulary be used to provide values for this element. Note: PRISM recommends against the use of the #other value currently allowed in this controlled vocabulary. In lieu of using #other please reach out to the PRISM group at info@prismstandard.org to request addition of your term to the Aggregation Type Controlled Vocabulary. aggregationType Text external Copyright copyright Text external The Digital Object Identifier for the article. The DOI may also be used as the dc:identifier. If used as a dc:identifier, the URI form should be captured, and the bare identifier should also be captured using prism:doi. If an alternate unique identifier is used as the required dc:identifier, then the DOI should be specified as a bare identifier within prism:doi only. If the URL associated with a DOI is to be specified, then prism:url may be used in conjunction with prism:doi in order to provide the service endpoint (i.e. the URL). doi Text external ISSN for an electronic version of the issue in which the resource occurs. Permits publishers to include a second ISSN, identifying an electronic version of the issue in which the resource occurs (therefore e(lectronic)Issn. If used, prism:eIssn MUST contain the ISSN of the electronic version. See prism:issn. issn Text external Title of the magazine, or other publication, in which a resource was/will be published. Typically this will be used to provide the name of the magazine an article appeared in as metadata for the article, along with information such as the article title, the publisher, volume, number, and cover date. Note: Publication name can be used to differentiate between a print magazine and the online version if the names are different such as “magazine” and “magazine.com.” publicationName Text external This element provides the url for an article or unit of content. The attribute platform is optionally allowed for situations in which multiple URLs must be specified. PRISM recommends that a subset of the PCV platform values, namely “mobile” and “web”, be used in conjunction with this element. NOTE: PRISM recommends against the use of the #other value allowed in the PRISM Platform controlled vocabulary. In lieu of using #other please reach out to the PRISM group at prism-wg@yahoogroups.com to request addition of your term to the Platform Controlled Vocabulary. url Text http://springernature.com/ns/xmpExtensions/2.0/ sn Springer Nature ORCID Schema external Author information: contains the name of each author and his/her ORCID (ORCiD: Open Researcher and Contributor ID). 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