f28afd66d864cf76b714a18798409c13 223752.pdf e91d0f8260dd23a28454f61a3643f78202228b9c 223752.pdf 34807099fd53fd8a307419dcb35444a8213be7d895749b75668e856c0180dc04 223752.pdf Title: Trisomy 21 activates the kynurenine pathway via increased dosage of interferon receptors Subject: Nature Communications, doi:10.1038/s41467-019-12739-9 Keywords: Author: Rani K. Powers Creator: Springer Producer: iText® 5.3.5 ©2000-2012 1T3XT BVBA (AGPL-version) CreationDate: Sat Oct 12 09:53:51 2019 CEST ModDate: Mon Oct 14 19:28:00 2019 CEST Tagged: no UserProperties: no Suspects: no Form: AcroForm JavaScript: no Pages: 11 Encrypted: no Page size: 595.276 x 782.362 pts Page rot: 0 File size: 892413 bytes Optimized: no PDF version: 1.4 name type encoding emb sub uni object ID ------------------------------------ ----------------- ---------------- --- --- --- --------- CHJMAK+AdvOTea1a7398 Type 1C WinAnsi yes yes no 65 0 CHJNIC+AdvOTea1a7398+20 Type 1C WinAnsi yes yes no 86 0 CHJNMC+AdvOTea1a7398+fb Type 1C Custom yes yes yes 87 0 CHJNMD+AdvOT9bd21c25.I Type 1C WinAnsi yes yes no 89 0 CHJNME+AdvOTcb88df00 Type 1C WinAnsi yes yes no 68 0 Arial-BoldMT Type 1C WinAnsi yes no no 690 0 CHJOBF+AdvTTda6f6cb8.B Type 1C WinAnsi yes yes no 72 0 CHJOAE+AdvOTf23bb480 Type 1C WinAnsi yes yes no 691 0 CHJOJE+AdvOT1ef757c0 Type 1C WinAnsi yes yes no 66 0 CHJOJF+AdvOT1ef757c0+fb Type 1C Custom yes yes yes 67 0 CHJOMH+AdvOT1ef757c0+03 Type 1C Custom yes yes yes 69 0 CHJOJD+AdvOT125c650c Type 1C WinAnsi yes yes no 70 0 CHJOMI+AdvOTb65e897d.B Type 1C WinAnsi yes yes no 71 0 CHJOKF+AdvOT1ef757c0+20 Type 1C WinAnsi yes yes no 73 0 CHJOLG+AdvOT7d6df7ab.I Type 1C WinAnsi yes yes no 74 0 MathPackTen Type 1C Custom yes no no 88 0 CHKAPA+AdvTTab7e17fd Type 1C WinAnsi yes yes no 90 0 CHKBBB+AdvOT8608a8d1+03 Type 1C Custom yes yes yes 91 0 CHJPEI+Helvetica-Oblique Type 1C WinAnsi yes yes no 92 0 CHJPFI+Symbol Type 1C Custom yes yes yes 93 0 CHJPCG+Helvetica-Bold Type 1C WinAnsi yes yes no 94 0 CHJPEH+Helvetica Type 1C Custom yes yes no 95 0 CHKBFA+AdvOT45bf69de.BI Type 1C WinAnsi yes yes no 186 0 MyriadPro-Regular Type 1C WinAnsi yes no no 204 0 CHKEMN+AdvTTab7e17fd+21 Type 1C Custom yes yes yes 309 0 CHKFEL+AdvTTab7e17fd+22 Type 1C Custom yes yes no 310 0 CHKFJK+AdvOTcb88df00+fb Type 1C Custom yes yes yes 381 0 CHKFNJ+AdvOT8608a8d1+20 Type 1C Custom yes yes yes 417 0 CHKGJG+AdvOTb65e897d.B+20 Type 1C WinAnsi yes yes no 459 0 Jhove (Rel. 1.22.1, 2019-04-17) Date: 2021-05-15 02:35:25 CEST RepresentationInformation: 223752.pdf ReportingModule: PDF-hul, Rel. 1.12.1 (2019-04-17) LastModified: 2021-05-14 19:36:24 CEST Size: 892413 Format: PDF Version: 1.4 Status: Well-Formed, but not valid SignatureMatches: PDF-hul ID: PDF-HUL-122 ErrorMessage: edu.harvard.hul.ois.jhove.module.pdf.PdfInvalidException: Invalid indirect destination - 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Powers Rachel Culp-Hill Michael P. Ludwig Keith P. Smith Katherine A. Waugh Ross Minter Kathryn D. Tuttle Hannah C. Lewis Angela L. Rachubinski Ross E. Granrath María Carmona-Iragui Rebecca B. Wilkerson Darcy E. Kahn Molishree Joshi Alberto Lleó Rafael Blesa Juan Fortea Angelo D’Alessandro James C. Costello Kelly D. Sullivan Joaquin M. Espinosa Springer US Nature Communications, doi:10.1038/s41467-019-12739-9 10.1038/s41467-019-12739-9 http://dx.doi.org/10.1038/s41467-019-12739-9 journal Nature Communications © 2019, The Author(s) 2041-1723 10.1038/s41467-019-12739-9 springer.com springerlink.com 2010-04-23 True 10.1038/s41467-019-12739-9 springer.com springerlink.com Springer 2019-10-14T19:28:00+02:00 2019-10-12T13:23:51+05:30 2019-10-14T19:28:00+02:00 True iText® 5.3.5 ©2000-2012 1T3XT BVBA (AGPL-version) VoR uuid:163d99fd-632b-4fea-9dc1-d385fe3c2c55 uuid:70ac7118-cc72-454a-98d5-04d54d774009 default 1 converted uuid:72b8e5d7-4065-4198-8ca5-026e03877438 converted to PDF/A-2b pdfToolbox 2019-10-12T13:24:52+05:30 2 B Kathryn D. Tuttle http://orcid.org/0000-0002-9285-5297 Ross E. Granrath http://orcid.org/0000-0002-9899-831X Kelly D. Sullivan http://orcid.org/0000-0003-2725-0205 http://ns.adobe.com/pdf/1.3/ pdf Adobe PDF Schema internal A name object indicating whether the document has been modified to include trapping information Trapped Text http://ns.adobe.com/pdfx/1.3/ pdfx pdfx internal ID of PDF/X standard GTS_PDFXVersion Text internal Conformance level of PDF/X standard GTS_PDFXConformance Text internal Company creating the PDF Company Text internal Date when document was last modified SourceModified Text external Mirrors crossmark:CrosMarkDomains CrossMarkDomains Seq Text internal Mirrors crossmark:DOI doi Text http://ns.adobe.com/xap/1.0/mm/ xmpMM XMP Media Management Schema internal UUID based identifier for specific incarnation of a document InstanceID URI internal The common identifier for all versions and renditions of a document. OriginalDocumentID URI http://www.aiim.org/pdfa/ns/id/ pdfaid PDF/A ID Schema internal Part of PDF/A standard part Integer internal Amendment of PDF/A standard amd Text internal Conformance level of PDF/A standard conformance Text http://crossref.org/crossmark/1.0/ crossmark crossmark internal CrossMarkDomains CrossMarkDomains Seq Text internal CrossmarkDomainExclusive CrossmarkDomainExclusive Text internal Usual same as prism:doi DOI Text external The date when a publication was published. MajorVersionDate Text http://prismstandard.org/namespaces/basic/2.0/ prism Prism external The aggregation type specifies the unit of aggregation for a content collection. Comment PRISM recommends that the PRISM Aggregation Type Controlled Vocabulary be used to provide values for this element. Note: PRISM recommends against the use of the #other value currently allowed in this controlled vocabulary. In lieu of using #other please reach out to the PRISM group at info@prismstandard.org to request addition of your term to the Aggregation Type Controlled Vocabulary. aggregationType Text external Copyright copyright Text external The Digital Object Identifier for the article. The DOI may also be used as the dc:identifier. If used as a dc:identifier, the URI form should be captured, and the bare identifier should also be captured using prism:doi. If an alternate unique identifier is used as the required dc:identifier, then the DOI should be specified as a bare identifier within prism:doi only. If the URL associated with a DOI is to be specified, then prism:url may be used in conjunction with prism:doi in order to provide the service endpoint (i.e. the URL). doi Text external ISSN for an electronic version of the issue in which the resource occurs. Permits publishers to include a second ISSN, identifying an electronic version of the issue in which the resource occurs (therefore e(lectronic)Issn. If used, prism:eIssn MUST contain the ISSN of the electronic version. See prism:issn. issn Text external Title of the magazine, or other publication, in which a resource was/will be published. Typically this will be used to provide the name of the magazine an article appeared in as metadata for the article, along with information such as the article title, the publisher, volume, number, and cover date. Note: Publication name can be used to differentiate between a print magazine and the online version if the names are different such as “magazine” and “magazine.com.” publicationName Text external This element provides the url for an article or unit of content. The attribute platform is optionally allowed for situations in which multiple URLs must be specified. PRISM recommends that a subset of the PCV platform values, namely “mobile” and “web”, be used in conjunction with this element. NOTE: PRISM recommends against the use of the #other value allowed in the PRISM Platform controlled vocabulary. In lieu of using #other please reach out to the PRISM group at prism-wg@yahoogroups.com to request addition of your term to the Platform Controlled Vocabulary. url Text http://springernature.com/ns/xmpExtensions/2.0/ sn Springer Nature ORCID Schema external Author information: contains the name of each author and his/her ORCID (ORCiD: Open Researcher and Contributor ID). 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