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Keywords: comorbidities, antipsychotics, risk factors, mortality, aging, memory, neuropsychiatric symptoms, social behavior Author: Virginia Torres-Lista Creator: Adobe InDesign CC 2015 (Windows) Producer: Adobe PDF Library 15.0 CreationDate: Mon Sep 23 11:35:07 2019 CEST ModDate: Mon Sep 23 12:40:46 2019 CEST Tagged: yes UserProperties: no Suspects: no Form: none JavaScript: no Pages: 25 Encrypted: no Page size: 595.276 x 779.528 pts Page rot: 0 File size: 6820058 bytes Optimized: no PDF version: 1.4 name type encoding emb sub uni object ID ------------------------------------ ----------------- ---------------- --- --- --- --------- HelveticaNeueLTStd-Bd Type 1C WinAnsi yes no yes 2196 0 HelveticaNeueLTStd-Lt Type 1C Custom yes no yes 2197 0 HelveticaNeueLTStd-MdIt Type 1C WinAnsi yes no yes 2208 0 HelveticaNeueLTStd-LtIt Type 1C Custom yes no yes 2209 0 HelveticaNeueLTStd-BdIt Type 1C WinAnsi yes no yes 2216 0 MinionPro-Regular Type 1C Custom yes no yes 272 0 MinionPro-It Type 1C Custom yes no yes 340 0 MinionPro-Bold Type 1C Custom yes no yes 398 0 Jhove (Rel. 1.22.1, 2019-04-17) Date: 2021-02-13 02:34:03 CET RepresentationInformation: fphar_a2019m9v10p1061.pdf ReportingModule: PDF-hul, Rel. 1.12.1 (2019-04-17) LastModified: 2021-02-12 12:50:26 CET Size: 6820058 Format: PDF Version: 1.4 Status: Well-Formed, but not valid SignatureMatches: PDF-hul ID: PDF-HUL-122 ErrorMessage: edu.harvard.hul.ois.jhove.module.pdf.PdfInvalidException: Invalid indirect destination - referenced object 'fphar.2019.01061.indd:mtc_Njung’e and Handley, 1991:9837' cannot be found Offset: 6732399 MIMEtype: application/pdf PDFMetadata: Objects: 2261 FreeObjects: 1783 IncrementalUpdates: 3 DocumentCatalog: ViewerPreferences: HideToolbar: false HideMenubar: false HideWindowUI: false FitWindow: false CenterWindow: false DisplayDocTitle: false NonFullScreenPageMode: UseNone Direction: L2R ViewArea: CropBox ViewClip: CropBox PrintArea: CropBox PageClip: CropBox PageLayout: SinglePage PageMode: UseOutlines Outlines: Item: Title: Impact of Chronic Risperidone Use on Behavior and Survival of 3xTg-AD Mice Model of Alzheimer’s Disease and Mice With Normal Aging Children: Item: Title: Introduction Item: Title: Materials and Methods Children: Item: Title: Animals Item: Title: Experimental Design and Risperidone Treatment Item: Title: Behavioral Assessments Item: Title: Corner Test (CT) Item: Title: Open Field Test (OF) Item: Title: T-Maze (TM) Item: Title: Social Interaction Test (SIT) Item: Title: Morris Water Maze (MWM) Item: Title: Marble Burying Test (MB) Item: Title: Body Weight (BW) and Basal Glucose Levels (G) Item: Title: Survival Curve Item: Title: Statistics Item: Title: Results Item: Title: Corner Test (CT) Item: Title: Open Field Test (OF) Item: Title: T-Maze (TM) Item: Title: Social Interaction Test (SIT) Item: Title: Morris Water Maze (MWM) Item: Title: Marble Burying Test (MB) Item: Title: Baseline State of Blood Glucose Item: Title: Weight Item: Title: Survival Curve Item: Title: Discussion Item: Title: Data Availability Item: Title: Ethics Statement Item: Title: Author Contributions Item: Title: Funding Item: Title: Acknowledgments Item: Title: Supplementary Material Item: Title: References Info: Title: Impact of Chronic Risperidone Use on Behavior and Survival of 3xTg-AD Mice Model of Alzheimer’s Disease and Mice With Normal Aging Author: Virginia Torres-Lista Subject: Psychosis and/or aggression are common problems in dementia, and when severe or persistent, cause considerable patient distress and disability, caregiver stress, and early institutionalization. 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