c0d504aebf3191ee3328eabc3b8375b6 PIIS0016508519411219.pdf 12649a6cbe68012b5c102b6c96c773bbb74e3c8c PIIS0016508519411219.pdf c562a8eba57630bdc83ff207b0023ea9d7fa4c82de86796b1234c0f8031953f5 PIIS0016508519411219.pdf Title: An Immune Gene Expression Signature Associated With Development of Human Hepatocellular Carcinoma Identifies Mice That Respond to Chemopreventive Agents Subject: Gastroenterology, 157 (2019) 1383-1408. doi:10.1053/j.gastro.2019.07.028 Author: Agrin Moeini Creator: Elsevier Producer: Acrobat Distiller 8.1.0 (Windows) CreationDate: 19th October 2019 ModDate: Tue May 11 09:39:15 2021 CEST Tagged: no UserProperties: no Suspects: no Form: none JavaScript: no Pages: 26 Encrypted: no Page size: 593.972 x 782.986 pts Page rot: 0 File size: 8180335 bytes Optimized: yes PDF version: 1.7 name type encoding emb sub uni object ID ------------------------------------ ----------------- ---------------- --- --- --- --------- NLFOKF+AdvOT9b311414.B Type 1C WinAnsi yes yes no 1244 0 NLFOLN+AdvTT08640291 Type 1C WinAnsi yes yes no 1246 0 NLFOMO+AdvTT08640291+fb Type 1C Custom yes yes yes 1249 0 NLFOMP+AdvP4C4E74 Type 1C Custom yes yes yes 1252 0 NLFONA+AdvTT9cc80a3e.I Type 1C WinAnsi yes yes no 1254 0 NLFONB+AdvTT9cc80a3e.I+fb Type 1C Custom yes yes yes 1257 0 NLFONC+AdvPS4721B4 Type 1C WinAnsi yes yes no 1259 0 NLFOND+AdvTT08640291+20 Type 1C WinAnsi yes yes no 1261 0 NLGCGO+AdvOTfadd598a.BI Type 1C WinAnsi yes yes no 1263 0 NLGCIO+AdvOTd1f5cc91.B+fb Type 1C Custom yes yes yes 1266 0 NLGEKC+AdvOT9b311414.B+20 Type 1C WinAnsi yes yes no 1268 0 NLFOLF+AdvOT9b311414.B+fb Type 1C Custom yes yes yes 1270 0 NLGEKD+AdvOT26268059.B Type 1C WinAnsi yes yes no 1272 0 NLFOLG+AdvOT7fe89a09 Type 1C WinAnsi yes yes no 1274 0 NLFOLH+AdvOT7fe89a09+fb Type 1C Custom yes yes yes 1276 0 NLFOLI+AdvOTc4f305bd.I Type 1C WinAnsi yes yes no 1278 0 NLFOLJ+AdvOTc4f305bd.I+20 Type 1C WinAnsi yes yes no 1280 0 NLFOLK+AdvOTc4f305bd.I+fb Type 1C Custom yes yes yes 1282 0 NLFOLL+AdvOTd1f5cc91.B Type 1C WinAnsi yes yes no 1284 0 NLFOLM+AdvTT0eeac7f7.B Type 1C WinAnsi yes yes no 1286 0 NLGEOD+AdvP4C4E51 Type 1C WinAnsi yes yes no 893 0 NLHPAD+AdvPS480274 Type 1C WinAnsi yes yes no 900 0 NLIBFG+AdvOT7fe89a09+20 Type 1C WinAnsi yes yes no 903 0 NLIBFH+AdvOTd1f5cc91.B+20 Type 1C WinAnsi yes yes no 901 0 NLIBFI+AdvPS_SSYB Type 1C WinAnsi yes yes no 904 0 Jhove (Rel. 1.22.1, 2019-04-17) Date: 2021-05-12 02:31:36 CEST RepresentationInformation: PIIS0016508519411219.pdf ReportingModule: PDF-hul, Rel. 1.12.1 (2019-04-17) LastModified: 2021-05-11 09:41:35 CEST Size: 8180335 Format: PDF Version: 1.7 Status: Well-Formed, but not valid SignatureMatches: PDF-hul ID: PDF-HUL-122 ErrorMessage: edu.harvard.hul.ois.jhove.module.pdf.PdfInvalidException: Invalid indirect destination - 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referenced object 'bib26' cannot be found Offset: 8170392 ID: PDF-HUL-122 ErrorMessage: edu.harvard.hul.ois.jhove.module.pdf.PdfInvalidException: Invalid indirect destination - referenced object 'bib26' cannot be found Offset: 8170392 ID: PDF-HUL-122 ErrorMessage: edu.harvard.hul.ois.jhove.module.pdf.PdfInvalidException: Invalid indirect destination - referenced object 'bib22' cannot be found Offset: 8170392 ID: PDF-HUL-122 ErrorMessage: edu.harvard.hul.ois.jhove.module.pdf.PdfInvalidException: Invalid indirect destination - referenced object 'bib26' cannot be found Offset: 8170392 ID: PDF-HUL-122 ErrorMessage: edu.harvard.hul.ois.jhove.module.pdf.PdfInvalidException: Invalid indirect destination - referenced object 'bib26' cannot be found Offset: 8170392 ID: PDF-HUL-122 ErrorMessage: edu.harvard.hul.ois.jhove.module.pdf.PdfInvalidException: Invalid indirect destination - referenced object 'bib38' cannot be found Offset: 8170392 ID: PDF-HUL-122 ErrorMessage: edu.harvard.hul.ois.jhove.module.pdf.PdfInvalidException: Invalid indirect destination - referenced object 'bib14' cannot be found Offset: 8170392 ID: PDF-HUL-122 ErrorMessage: edu.harvard.hul.ois.jhove.module.pdf.PdfInvalidException: Invalid indirect destination - referenced object 'bib40' cannot be found Offset: 8170392 ID: PDF-HUL-122 ErrorMessage: edu.harvard.hul.ois.jhove.module.pdf.PdfInvalidException: Invalid indirect destination - referenced object 'bib26' cannot be found Offset: 8170392 ID: PDF-HUL-122 ErrorMessage: edu.harvard.hul.ois.jhove.module.pdf.PdfInvalidException: Invalid indirect destination - referenced object 'bib34' cannot be found Offset: 8170392 ID: PDF-HUL-122 ErrorMessage: edu.harvard.hul.ois.jhove.module.pdf.PdfInvalidException: Invalid indirect destination - referenced object 'bib43' cannot be found Offset: 8170392 ID: PDF-HUL-122 ErrorMessage: edu.harvard.hul.ois.jhove.module.pdf.PdfInvalidException: Invalid indirect destination - referenced object 'bib43' cannot be found Offset: 8170392 ID: PDF-HUL-122 ErrorMessage: edu.harvard.hul.ois.jhove.module.pdf.PdfInvalidException: Invalid indirect destination - 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referenced object 'bib32' cannot be found Offset: 8170392 ID: PDF-HUL-122 ErrorMessage: edu.harvard.hul.ois.jhove.module.pdf.PdfInvalidException: Invalid indirect destination - referenced object 'bib15' cannot be found Offset: 8170392 ID: PDF-HUL-122 ErrorMessage: edu.harvard.hul.ois.jhove.module.pdf.PdfInvalidException: Invalid indirect destination - referenced object 'bib12' cannot be found Offset: 8170392 ID: PDF-HUL-122 ErrorMessage: edu.harvard.hul.ois.jhove.module.pdf.PdfInvalidException: Invalid indirect destination - referenced object 'bib53' cannot be found Offset: 8170392 ID: PDF-HUL-122 ErrorMessage: edu.harvard.hul.ois.jhove.module.pdf.PdfInvalidException: Invalid indirect destination - referenced object 'bib54' cannot be found Offset: 8170392 ID: PDF-HUL-122 ErrorMessage: edu.harvard.hul.ois.jhove.module.pdf.PdfInvalidException: Invalid indirect destination - referenced object 'bib53' cannot be found Offset: 8170392 ID: PDF-HUL-122 ErrorMessage: edu.harvard.hul.ois.jhove.module.pdf.PdfInvalidException: Invalid indirect destination - referenced object 'bib56' cannot be found Offset: 8170392 ID: PDF-HUL-122 ErrorMessage: edu.harvard.hul.ois.jhove.module.pdf.PdfInvalidException: Invalid indirect destination - referenced object 'bib57' cannot be found Offset: 8170392 ID: PDF-HUL-122 ErrorMessage: edu.harvard.hul.ois.jhove.module.pdf.PdfInvalidException: Invalid indirect destination - referenced object 'bib58' cannot be found Offset: 8170392 ID: PDF-HUL-129 InfoMessage: Outlines contain recursive references. MIMEtype: application/pdf Profile: Linearized PDF PDFMetadata: Objects: 0 FreeObjects: 1 IncrementalUpdates: 0 DocumentCatalog: PageLayout: SinglePage PageMode: UseOutlines Outlines: Item: Title: Materials and Methods Destination: edu.harvard.hul.ois.jhove.module.pdf.PdfSimpleObject@8646db9 Children: Item: Title: Human Cohort Destination: edu.harvard.hul.ois.jhove.module.pdf.PdfSimpleObject@37374a5e Item: Title: Modeling the Immune-Mediated Cancer Field Destination: edu.harvard.hul.ois.jhove.module.pdf.PdfSimpleObject@4671e53b Item: Title: Generation of an Immune-Mediated Field Gene Signature Destination: edu.harvard.hul.ois.jhove.module.pdf.PdfSimpleObject@2db7a79b Item: Title: Molecular Characterization of the Immune-Mediated Cancer Field Subtypes and Identification of Candidate Therapies Destination: edu.harvard.hul.ois.jhove.module.pdf.PdfSimpleObject@6950e31 Item: Title: Histologic Evaluation of Infiltrating Inflammation Destination: edu.harvard.hul.ois.jhove.module.pdf.PdfSimpleObject@b7dd107 Item: Title: Animal Models Destination: edu.harvard.hul.ois.jhove.module.pdf.PdfSimpleObject@42eca56e Item: Title: Statistical Analysis Destination: edu.harvard.hul.ois.jhove.module.pdf.PdfSimpleObject@52f759d7 Item: Title: Transcript Profiling Destination: edu.harvard.hul.ois.jhove.module.pdf.PdfSimpleObject@7cbd213e Item: Title: Results Destination: edu.harvard.hul.ois.jhove.module.pdf.PdfSimpleObject@192d3247 Children: Item: Title: Nintedanib Treatment Reverts the Immune-Mediated Cancer Field Effect Destination: edu.harvard.hul.ois.jhove.module.pdf.PdfSimpleObject@3ecd23d9 Item: Title: Nintedanib Treatment Reverts the Immune-Mediated Cancer Field Effect Destination: edu.harvard.hul.ois.jhove.module.pdf.PdfSimpleObject@569cfc36 Item: Title: Discussion Destination: edu.harvard.hul.ois.jhove.module.pdf.PdfSimpleObject@43bd930a Item: Title: Supplementary Material Destination: edu.harvard.hul.ois.jhove.module.pdf.PdfSimpleObject@33723e30 Item: Title: References Destination: edu.harvard.hul.ois.jhove.module.pdf.PdfSimpleObject@64f6106c Item: Title: Acknowledgements Destination: edu.harvard.hul.ois.jhove.module.pdf.PdfSimpleObject@553a3d88 Item: Title: Supplementary Methods Destination: edu.harvard.hul.ois.jhove.module.pdf.PdfSimpleObject@7a30d1e6 Children: Item: Title: Histologic Analysis of Human Samples Destination: edu.harvard.hul.ois.jhove.module.pdf.PdfSimpleObject@5891e32e Item: Title: Generation of the Diethylnitrosamine/Carbon Tetrachloride Animal Model Destination: edu.harvard.hul.ois.jhove.module.pdf.PdfSimpleObject@cb0ed20 Item: Title: Histologic and Immunohistochemical Analysis of the Mouse Samples Destination: edu.harvard.hul.ois.jhove.module.pdf.PdfSimpleObject@8e24743 Item: Title: RNA Extraction and Gene Expression Profiling of Mice Livers Destination: edu.harvard.hul.ois.jhove.module.pdf.PdfSimpleObject@74a10858 Item: Title: Western Blot 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FontSubset: true FirstChar: 60 LastChar: 62 FontDescriptor: FontName: NLGEOD+AdvP4C4E51 Flags: Nonsymbolic FontBBox: -31, -239, 1041, 750 FontFile3: true Encoding: WinAnsiEncoding Font: BaseFont: NLFOLI+AdvOTc4f305bd.I FontSubset: true FirstChar: 40 LastChar: 243 FontDescriptor: FontName: NLFOLI+AdvOTc4f305bd.I Flags: Nonsymbolic FontBBox: -125, -208, 979, 947 FontFile3: true Encoding: WinAnsiEncoding XMP: application/pdf doi:10.1053/j.gastro.2019.07.028 An Immune Gene Expression Signature Associated With Development of Human Hepatocellular Carcinoma Identifies Mice That Respond to Chemopreventive Agents Agrin Moeini Sara Torrecilla Victoria Tovar Carla Montironi Carmen Andreu-Oller Judit Peix Mónica Higuera Dominik Pfister Pierluigi Ramadori Roser Pinyol Manel Solé Mathias Heikenwälder Scott L. Friedman Daniela Sia Josep M. Llovet Cancer Microenvironment Cytokines Lymphocytes Gastroenterology, 157 (2019) 1383-1408. doi:10.1053/j.gastro.2019.07.028 Elsevier, Inc journal Gastroenterology © 2019 by the AGA Institute 0016-5085 157 5 November 2019 1383-1397.e11 1383 1397.e11 10.1053/j.gastro.2019.07.028 https://doi.org/10.1053/j.gastro.2019.07.028 2010-04-23 true 10.1053/j.gastro.2019.07.028 elsevier.com sciencedirect.com VoR 6.5 10.1053/j.gastro.2019.07.028 noindex 2010-04-23 true 19th October 2019 sciencedirect.com elsevier.com Elsevier 2021-05-11T09:39:15+02:00 2021-05-11T09:39:15+02:00 True 19th October 2019 Acrobat Distiller 8.1.0 (Windows) uuid:58744d03-e112-4c63-b72d-f570cb21f1fd uuid:e34ef8cc-655b-4e69-9f42-7bcb30819284 Pages: Page: Label: 1383 Sequence: 1 Annotations: Annotation: Subtype: Link Rect: 119, 608, 124, 620 Destination: null Annotation: Subtype: Link Rect: 207, 608, 212, 620 Destination: null Annotation: Subtype: Link Rect: 293, 608, 298, 620 Destination: null Annotation: Subtype: Link 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Sequence: 26 Checksum: 9a1c6ee3 Type: CRC32 Checksum: c0d504aebf3191ee3328eabc3b8375b6 Type: MD5 Checksum: 12649a6cbe68012b5c102b6c96c773bbb74e3c8c Type: SHA-1