937eb3a4ae2579ba82bd7d212162fda9 pdf_223840.pdf fdfb7a619b74d5153875b12a16bbe05e35b9328d pdf_223840.pdf 46c179b9c140fd2c1ee93c2175fe4613092a266c03797c05e433a55a6ccb73a1 pdf_223840.pdf Title: Reimbursement Status and Recommendations Related to Orphan Drugs in European Countries Subject: Objective: To review the reimbursement recommendations issued by selected European health technology assessment agencies for orphan drugs and the reimbursement status of these drugs; to assess the relationship between the type of recommendation and reimb Keywords: health technology assessment, drug policy, rare disease, reimbursement, orphan Author: Ewa Stawowczyk Creator: Adobe InDesign CC 2015 (Windows) Producer: Adobe PDF Library 15.0 CreationDate: Tue Nov 26 06:42:43 2019 CET ModDate: Mon Apr 26 14:41:48 2021 CEST Tagged: yes UserProperties: no Suspects: no Form: none JavaScript: no Pages: 9 Encrypted: no Page size: 595.276 x 779.528 pts Page rot: 0 File size: 951969 bytes Optimized: yes PDF version: 1.4 name type encoding emb sub uni object ID ------------------------------------ ----------------- ---------------- --- --- --- --------- HelveticaNeueLTStd-Bd Type 1C WinAnsi yes no yes 1316 0 HelveticaNeueLTStd-BdIt Type 1C WinAnsi yes no yes 1317 0 HelveticaNeueLTStd-LtIt Type 1C Custom yes no yes 1318 0 HelveticaNeueLTStd-MdIt Type 1C Custom yes no yes 1327 0 HelveticaNeueLTStd-Lt Type 1C Custom yes no yes 1329 0 MinionPro-Regular Type 1C Custom yes no yes 1330 0 MinionPro-Bold Type 1C Custom yes no yes 77 0 MinionPro-It Type 1C Custom yes no yes 81 0 Jhove (Rel. 1.22.1, 2019-04-17) Date: 2021-04-27 02:33:10 CEST RepresentationInformation: pdf_223840.pdf ReportingModule: PDF-hul, Rel. 1.12.1 (2019-04-17) LastModified: 2021-04-26 14:42:03 CEST Size: 951969 Format: PDF Version: 1.4 Status: Well-Formed, but not valid SignatureMatches: PDF-hul ErrorMessage: Annotation object is not a dictionary Offset: 4068 MIMEtype: application/pdf Profile: Linearized PDF PDFMetadata: Objects: 1402 FreeObjects: 1204 IncrementalUpdates: 1 DocumentCatalog: ViewerPreferences: HideToolbar: false HideMenubar: false HideWindowUI: false FitWindow: false CenterWindow: false DisplayDocTitle: false NonFullScreenPageMode: UseNone Direction: L2R ViewArea: CropBox ViewClip: CropBox PrintArea: CropBox PageClip: CropBox PageLayout: SinglePage PageMode: UseOutlines Outlines: Item: Title: Reimbursement Status and Recommendations Related to Orphan Drugs in European Countries Children: Item: Title: Background Item: Title: Methods Item: Title: Results Children: Item: Title: Reimbursement Recommendations for Orphan Drugs Item: Title: Reimbursement Status for Orphan Drugs Item: Title: Agreement in Reimbursement Status Between Countries Item: Title: Agreement in Recommendations Between Countries Item: Title: Agreement Between Recommendations and Reimbursement Status Within Countries Item: Title: Discussion Item: Title: Conclusions Item: Title: Data Availability Statement Item: Title: Author Contributions Item: Title: Funding Item: Title: Supplementary Material Item: Title: References Info: Title: Reimbursement Status and Recommendations Related to Orphan Drugs in European Countries Author: Ewa Stawowczyk Subject: Objective: To review the reimbursement recommendations issued by selected European health technology assessment agencies for orphan drugs and the reimbursement status of these drugs; to assess the relationship between the type of recommendation and reimb Keywords: health technology assessment, drug policy, rare disease, reimbursement, orphan Creator: Adobe InDesign CC 2015 (Windows) Producer: Adobe PDF Library 15.0 CreationDate: Tue Nov 26 06:42:43 CET 2019 ModDate: Mon Apr 26 14:41:48 CEST 2021 ID: 0x1296c8c772ed7849a7f7bca83896490c, 0xcd0531e61de4f24c8faca0f92ba524ca Filters: FilterPipeline: FlateDecode FilterPipeline: DCTDecode Images: Image: NisoImageMetadata: FormatName: image/png ImageWidth: 968 ImageHeight: 564 ColorSpace: black is zero BitsPerSample: 8 BitsPerSampleUnit: integer Filter: FlateDecode Intent: RelativeColorimetric Name: X Image: NisoImageMetadata: FormatName: image/png ImageWidth: 968 ImageHeight: 581 ColorSpace: black is zero BitsPerSample: 8 BitsPerSampleUnit: integer Filter: FlateDecode Intent: RelativeColorimetric Name: X Image: NisoImageMetadata: FormatName: image/jpg CompressionScheme: JPEG ImageWidth: 968 ImageHeight: 560 ColorSpace: black is zero BitsPerSample: 8 BitsPerSampleUnit: integer Intent: RelativeColorimetric Name: X Image: NisoImageMetadata: FormatName: image/jpg CompressionScheme: JPEG ImageWidth: 968 ImageHeight: 658 ColorSpace: black is zero BitsPerSample: 8 BitsPerSampleUnit: integer Intent: RelativeColorimetric Name: X Image: NisoImageMetadata: FormatName: image/jpg CompressionScheme: JPEG ImageWidth: 968 ImageHeight: 614 ColorSpace: black is zero BitsPerSample: 8 BitsPerSampleUnit: integer Intent: RelativeColorimetric Name: X Fonts: Type1: Font: BaseFont: HelveticaNeueLTStd-Lt FirstChar: 0 LastChar: 255 FontDescriptor: FontName: HelveticaNeueLTStd-Lt Flags: Nonsymbolic FontBBox: -166, -295, 1050, 967 FontFile3: true EncodingDictionary: BaseEncoding: WinAnsiEncoding Differences: true ToUnicode: true Font: BaseFont: MinionPro-It FirstChar: 0 LastChar: 255 FontDescriptor: FontName: MinionPro-It Flags: Serif, Nonsymbolic, Italic FontBBox: -201, -360, 1684, 1002 FontFile3: true EncodingDictionary: BaseEncoding: WinAnsiEncoding Differences: true ToUnicode: true Font: BaseFont: MinionPro-Regular FirstChar: 0 LastChar: 255 FontDescriptor: FontName: MinionPro-Regular Flags: Serif, Nonsymbolic FontBBox: -290, -360, 1684, 989 FontFile3: true EncodingDictionary: BaseEncoding: WinAnsiEncoding Differences: true ToUnicode: true Font: BaseFont: HelveticaNeueLTStd-Bd FirstChar: 0 LastChar: 255 FontDescriptor: FontName: HelveticaNeueLTStd-Bd Flags: Nonsymbolic FontBBox: -166, -387, 1078, 975 FontFile3: true Encoding: WinAnsiEncoding ToUnicode: true Font: BaseFont: HelveticaNeueLTStd-BdIt FirstChar: 0 LastChar: 255 FontDescriptor: FontName: HelveticaNeueLTStd-BdIt Flags: Nonsymbolic FontBBox: -166, -393, 1129, 975 FontFile3: true Encoding: WinAnsiEncoding ToUnicode: true Font: BaseFont: HelveticaNeueLTStd-LtIt FirstChar: 0 LastChar: 255 FontDescriptor: FontName: HelveticaNeueLTStd-LtIt Flags: Nonsymbolic FontBBox: -165, -303, 1099, 951 FontFile3: true EncodingDictionary: BaseEncoding: WinAnsiEncoding Differences: true ToUnicode: true Font: BaseFont: MinionPro-Bold FirstChar: 0 LastChar: 255 FontDescriptor: FontName: MinionPro-Bold Flags: Serif, Nonsymbolic FontBBox: -319, -360, 1684, 1024 FontFile3: true EncodingDictionary: BaseEncoding: WinAnsiEncoding Differences: true ToUnicode: true Font: BaseFont: HelveticaNeueLTStd-MdIt FirstChar: 0 LastChar: 255 FontDescriptor: FontName: HelveticaNeueLTStd-MdIt Flags: Nonsymbolic, Italic FontBBox: -165, -218, 1125, 947 FontFile3: true EncodingDictionary: BaseEncoding: WinAnsiEncoding Differences: true ToUnicode: true XMP: application/pdf Reimbursement Status and Recommendations Related to Orphan Drugs in European Countries Ewa Stawowczyk Krzysztof Piotr Malinowski Paweł Kawalec Rafał Bobin´ski Jacek Siwiec Dimitra Panteli Helene Eckhardt Steven Simoens Antònia Agusti Marc Dooms Andrzej Pilc Objective: To review the reimbursement recommendations issued by selected European health technology assessment agencies for orphan drugs and the reimbursement status of these drugs; 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