f4ba7b5187507a4e9859838d24b1516b 223914.pdf 35089f3676cf253e575a004d053f0c741abab9e4 223914.pdf 450dc1b796f3ebffa75934ef9e1415ce5d19ee61bbb1a7722a0b58746177c277 223914.pdf Title: Genetic variation across RNA metabolism and cell death gene networks is implicated in the semantic variant of primary progressive aphasia Subject: Scientific Reports, doi:10.1038/s41598-019-46415-1 Keywords: Author: Luke W. Bonham Creator: Springer Producer: iText® 5.3.5 ©2000-2012 1T3XT BVBA (AGPL-version) CreationDate: Fri Jul 19 18:27:57 2019 CEST ModDate: Mon Jul 22 15:41:12 2019 CEST Tagged: no UserProperties: no Suspects: no Form: AcroForm JavaScript: no Pages: 10 Encrypted: no Page size: 595.276 x 782.362 pts Page rot: 0 File size: 1350120 bytes Optimized: no PDF version: 1.4 name type encoding emb sub uni object ID ------------------------------------ ----------------- ---------------- --- --- --- --------- OQJTPB+Corbel-Bold CID TrueType Identity-H yes yes yes 182 0 AKCDLM+Corbel-BoldItalic Type 1C WinAnsi yes yes yes 326 0 YTAMZH+STIXGeneral-Regular Type 1C Custom yes yes yes 146 0 DERQYA+Corbel-Bold2 Type 1C WinAnsi yes yes yes 52 0 MinionPro-Regular Type 1C Custom yes no yes 51 0 YNRQJJ+Corbel2 Type 1C WinAnsi yes yes yes 55 0 YPNGZH+Corbel CID TrueType Identity-H yes yes yes 56 0 MyriadPro-It Type 1C WinAnsi yes no yes 57 0 OWIQPB+TimesNewRomanPSMT Type 1C WinAnsi yes yes yes 327 0 YNRQJJ+Corbel2 Type 1C WinAnsi yes yes yes 270 0 EuclidSymbol Type 1C Custom yes no yes 50 0 MinionPro-Bold Type 1C WinAnsi yes no yes 53 0 MinionPro-It Type 1C Custom yes no yes 54 0 YNRQJJ+Corbel2 Type 1C WinAnsi yes yes yes 257 0 Jhove (Rel. 1.22.1, 2019-04-17) Date: 2021-05-28 03:01:20 CEST RepresentationInformation: 223914.pdf ReportingModule: PDF-hul, Rel. 1.12.1 (2019-04-17) LastModified: 2021-05-27 13:29:43 CEST Size: 1350120 Format: PDF Version: 1.4 Status: Well-Formed, but not valid SignatureMatches: PDF-hul ID: PDF-HUL-122 ErrorMessage: edu.harvard.hul.ois.jhove.module.pdf.PdfInvalidException: Invalid indirect destination - referenced object 'SpringerNature_SciRep_46415.indd:Figure 1. svPPA Network. Network results are shown for protein interaction network based pathway analysis (PINBPA) in the semantic variant of primary progressive aphasia compared to controls. The network genes are color coded according to their :40' cannot be found Offset: 971429 ID: PDF-HUL-122 ErrorMessage: edu.harvard.hul.ois.jhove.module.pdf.PdfInvalidException: Invalid indirect destination - referenced object 'SpringerNature_SciRep_46415.indd:Figure 2. svPPA Interactome Analyses. (A) Results from the weighted protein-protein interaction network analysis (W-PPI-NA) pipeline are shown for the 64 genes identified using protein interaction network based pathway analysis (PINBPA). Seeds:49' cannot be found Offset: 971429 ID: PDF-HUL-122 ErrorMessage: edu.harvard.hul.ois.jhove.module.pdf.PdfInvalidException: Invalid indirect destination - referenced object 'SpringerNature_SciRep_46415.indd:Figure 2. svPPA Interactome Analyses. (A) Results from the weighted protein-protein interaction network analysis (W-PPI-NA) pipeline are shown for the 64 genes identified using protein interaction network based pathway analysis (PINBPA). Seed:50' cannot be found Offset: 971429 ID: PDF-HUL-122 ErrorMessage: edu.harvard.hul.ois.jhove.module.pdf.PdfInvalidException: Invalid indirect destination - referenced object 'SpringerNature_SciRep_46415.indd:Figure 2. svPPA Interactome Analyses. (A) Results from the weighted protein-protein interaction network analysis (W-PPI-NA) pipeline are shown for the 64 genes identified using protein interaction network based pathway analysis (PINBPA). See:51' cannot be found Offset: 971429 ID: PDF-HUL-122 ErrorMessage: edu.harvard.hul.ois.jhove.module.pdf.PdfInvalidException: Invalid indirect destination - referenced object 'SpringerNature_SciRep_46415.indd:Figure 2. svPPA Interactome Analyses. (A) Results from the weighted protein-protein interaction network analysis (W-PPI-NA) pipeline are shown for the 64 genes identified using protein interaction network based pathway analysis (PINBPA). Se:52' cannot be found Offset: 971429 ID: PDF-HUL-122 ErrorMessage: edu.harvard.hul.ois.jhove.module.pdf.PdfInvalidException: Invalid indirect destination - referenced object 'SpringerNature_SciRep_46415.indd:Figure 3. g:profiler Biological Pathway Analyses. Comparison of the g:Profiler functional enrichment performed for the entire weighted protein-protein interaction network analysis (W-PPI-NA) network (blue bars) and the core network (red bars). G:53' cannot be found Offset: 971429 ID: PDF-HUL-122 ErrorMessage: edu.harvard.hul.ois.jhove.module.pdf.PdfInvalidException: Invalid indirect destination - referenced object 'SpringerNature_SciRep_46415.indd:Figure 3. g:profiler Biological Pathway Analyses. Comparison of the g:Profiler functional enrichment performed for the entire weighted protein-protein interaction network analysis (W-PPI-NA) network (blue bars) and the core network (red bars). :54' cannot be found Offset: 971429 MIMEtype: application/pdf PDFMetadata: Objects: 397 FreeObjects: 1 IncrementalUpdates: 0 DocumentCatalog: ViewerPreferences: HideToolbar: false HideMenubar: false HideWindowUI: false FitWindow: false CenterWindow: false DisplayDocTitle: false NonFullScreenPageMode: UseNone Direction: L2R ViewArea: CropBox ViewClip: CropBox PrintArea: CropBox PageClip: CropBox PageLayout: SinglePage PageMode: UseOutlines Language: EN Outlines: Item: Title: Genetic variation across RNA metabolism and cell death gene networks is implicated in the semantic variant of primary progr ... Children: Item: Title: Results Item: Title: Discussion Item: Title: Methods Children: Item: Title: Ethics, consent and permissions. Item: Title: svPPA gene network generation. Item: Title: Gene expression in pathologically confirmed FTLD cases. Item: Title: svPPA biological pathway enrichment analysis. Item: Title: Acknowledgements Item: Title: Figure 1 svPPA Network. Item: Title: Figure 2 svPPA Interactome Analyses. Item: Title: Figure 3 g:profiler Biological Pathway Analyses. Item: Title: Table 1 Differential Expression Analyses in FTLD-U Cases. Item: Title: Table 2 Reactome Pathway Analysis: Genes Implicated in svPPA Protein Network. Info: Title: Genetic variation across RNA metabolism and cell death gene networks is implicated in the semantic variant of primary progressive aphasia Author: Luke W. Bonham Subject: Scientific Reports, doi:10.1038/s41598-019-46415-1 Keywords: Creator: Springer Producer: iText® 5.3.5 ©2000-2012 1T3XT BVBA (AGPL-version) CreationDate: Fri Jul 19 18:57:57 CEST 2019 ModDate: Mon Jul 22 15:41:12 CEST 2019 ID: 0xed7ee81285678715f438620214527505, 0xa12c76a86d7531f54db1776ecd35905d Filters: FilterPipeline: FlateDecode FilterPipeline: DCTDecode Images: Image: NisoImageMetadata: FormatName: image/png ImageWidth: 1100 ImageHeight: 90 ColorSpace: black is zero BitsPerSample: 1 BitsPerSampleUnit: integer Filter: FlateDecode Intent: RelativeColorimetric Name: X Image: NisoImageMetadata: FormatName: image/jpg CompressionScheme: JPEG ImageWidth: 1650 ImageHeight: 715 BitsPerSample: 8 BitsPerSampleUnit: integer Intent: RelativeColorimetric Name: X Image: NisoImageMetadata: FormatName: image/jpg CompressionScheme: JPEG ImageWidth: 1350 ImageHeight: 767 BitsPerSample: 8 BitsPerSampleUnit: integer Intent: RelativeColorimetric Name: X Image: NisoImageMetadata: FormatName: image/jpg CompressionScheme: JPEG ImageWidth: 1650 ImageHeight: 1268 BitsPerSample: 8 BitsPerSampleUnit: integer Intent: RelativeColorimetric Name: X Fonts: Type0: Font: BaseFont: OQJTPB+Corbel-Bold Encoding: Identity-H ToUnicode: true Font: BaseFont: YPNGZH+Corbel Encoding: Identity-H ToUnicode: true Type1: Font: BaseFont: YTAMZH+STIXGeneral-Regular FontSubset: true FirstChar: 31 LastChar: 31 FontDescriptor: FontName: YTAMZH+STIXGeneral-Regular Flags: Serif, Symbolic FontBBox: -995, -455, 2000, 1055 FontFile3: true EncodingDictionary: BaseEncoding: WinAnsiEncoding Differences: true ToUnicode: true Font: BaseFont: EuclidSymbol FirstChar: 0 LastChar: 255 FontDescriptor: FontName: EuclidSymbol Flags: Symbolic FontBBox: -166, -253, 1090, 950 FontFile3: true EncodingDictionary: BaseEncoding: WinAnsiEncoding Differences: true ToUnicode: true Font: BaseFont: MinionPro-Regular FirstChar: 0 LastChar: 255 FontDescriptor: FontName: MinionPro-Regular Flags: Serif, Nonsymbolic FontBBox: -290, -360, 1684, 989 FontFile3: true EncodingDictionary: BaseEncoding: WinAnsiEncoding Differences: true ToUnicode: true Font: BaseFont: DERQYA+Corbel-Bold2 FontSubset: true FirstChar: 0 LastChar: 255 FontDescriptor: FontName: DERQYA+Corbel-Bold2 Flags: Nonsymbolic FontBBox: -556, -239, 1155, 952 FontFile3: true Encoding: WinAnsiEncoding ToUnicode: true Font: BaseFont: MinionPro-Bold FirstChar: 0 LastChar: 255 FontDescriptor: FontName: MinionPro-Bold Flags: Serif, Nonsymbolic FontBBox: -319, -360, 1684, 1024 FontFile3: true Encoding: WinAnsiEncoding ToUnicode: true Font: BaseFont: AKCDLM+Corbel-BoldItalic FontSubset: true FirstChar: 0 LastChar: 255 FontDescriptor: FontName: AKCDLM+Corbel-BoldItalic Flags: Nonsymbolic, Italic FontBBox: -494, -239, 1194, 952 FontFile3: true Encoding: WinAnsiEncoding ToUnicode: true Font: BaseFont: MinionPro-It FirstChar: 0 LastChar: 255 FontDescriptor: FontName: MinionPro-It Flags: Serif, Nonsymbolic, Italic FontBBox: -201, -360, 1684, 1002 FontFile3: true EncodingDictionary: BaseEncoding: WinAnsiEncoding Differences: true ToUnicode: true Font: BaseFont: YNRQJJ+Corbel2 FontSubset: true FirstChar: 0 LastChar: 255 FontDescriptor: FontName: YNRQJJ+Corbel2 Flags: Nonsymbolic FontBBox: -553, -239, 1110, 952 FontFile3: true Encoding: WinAnsiEncoding ToUnicode: true Font: BaseFont: OWIQPB+TimesNewRomanPSMT FontSubset: true FirstChar: 32 LastChar: 120 FontDescriptor: FontName: OWIQPB+TimesNewRomanPSMT Flags: Serif, Nonsymbolic FontBBox: -568, -307, 2000, 1007 FontFile3: true Encoding: WinAnsiEncoding ToUnicode: true Font: BaseFont: MyriadPro-It FirstChar: 0 LastChar: 255 FontDescriptor: FontName: MyriadPro-It Flags: Nonsymbolic, Italic FontBBox: -185, -250, 1090, 953 FontFile3: true Encoding: WinAnsiEncoding ToUnicode: true CIDFontType2: Font: BaseFont: YPNGZH+Corbel CIDSystemInfo: Registry: Adobe Registry: Identity Supplement: 0 FontDescriptor: FontName: YPNGZH+Corbel Flags: Symbolic FontBBox: -553, -239, 1110, 952 FontFile2: true Font: BaseFont: OQJTPB+Corbel-Bold CIDSystemInfo: Registry: Adobe Registry: Identity Supplement: 0 FontDescriptor: FontName: OQJTPB+Corbel-Bold Flags: Symbolic FontBBox: -556, -239, 1155, 952 FontFile2: true XMP: application/pdf doi:10.1038/s41598-019-46415-1 Springer US Scientific Reports, doi:10.1038/s41598-019-46415-1 Genetic variation across RNA metabolism and cell death gene networks is implicated in the semantic variant of primary progressive aphasia Luke W. Bonham Natasha Z. R. Steele Celeste M. Karch Iris Broce Ethan G. Geier Natalie L. Wen Parastoo Momeni John Hardy Zachary A. Miller Maria Luisa Gorno-Tempini Christopher P. Hess Patrick Lewis Bruce L. Miller William W. Seeley Claudia Manzoni Rahul S. Desikan Sergio E. Baranzini Raffaele Ferrari Jennifer S. Yokoyama D. G. Hernandez M. A. Nalls J. D. Rohrer A. Ramasamy J. B. J. Kwok C. Dobson-Stone P. R. Schofield G. M. Halliday J. R. Hodges O. Piguet L. Bartley E. Thompson E. Haan I. Hernamp#x000E1;ndez A. Ruiz M. Boada B. Borroni A. Padovani C. Cruchaga N. J. Cairns L. Benussi G. Binetti R. Ghidoni G. Forloni D. Albani D. Galimberti C. Fenoglio M. Serpente E. Scarpini J. Clarimamp#x000F3;n A. Lleamp#x000F3; R. Blesa M. Landqvistamp#x000A0;Waldamp#x000F6; K. Nilsson C. Nilsson I. R. A. Mackenzie G. -Y. R. Hsiung D. M. A. Mann J. Grafman C. M. Morris J. Attems T. D. Griffiths I. G. McKeith A. J. Thomas P. Pietrini E. D. Huey E. M. Wassermann A. Baborie E. Jaros M. C. Tierney P. Pastor C. Razquin S. Ortega-Cubero E. Alonso R. Perneczky J. Diehl-Schmid P. Alexopoulos A. Kurz I. Rainero E. Rubino L. Pinessi E. Rogaeva P. St George-Hyslop G. Rossi F. Tagliavini G. Giaccone J. B. Rowe J. C. M. Schlachetzki J. Uphill J. Collinge S. Mead A. Danek V. M. Vanamp#x000A0;Deerlin M. Grossman J. Q. Trojanowski J. van der Zee M. Cruts C. Vanamp#x000A0;Broeckhoven S. F. Cappa I. Leber D. Hannequin V. Golfier M. Vercelletto A. Brice B. Nacmias S. Sorbi S. Bagnoli I. Piaceri J. E. Nielsen L. E. Hjermind M. Riemenschneider M. Mayhaus B. Ibach G. Gasparoni S. Pichler W. Gu M. N. Rossor N. C. Fox J. D. Warren M. G. Spillantini H. R. Morris P. Rizzu P. Heutink J. S. Snowden S. Rollinson A. Richardson A. Gerhard A. C. Bruni R. Maletta F. Frangipane C. Cupidi L. Bernardi M. Anfossi M. Gallo M. E. Conidi N. Smirne R. Rademakers M. Baker D. W. Dickson N. R. Graff-Radford R. C. Petersen D. Knopman K. A. Josephs B. F. Boeve J. E. Parisi A. M. Karydas H. Rosen J. C. van Swieten E. G. P. Dopper H. Seelaar Y. A. L. Pijnenburg P. Scheltens G. Logroscino R. Capozzo V. Novelli A. A. Puca M. Franceschi A. Postiglione G. Milan P. Sorrentino M. Kristiansen H. -H. Chiang C. Graff F. Pasquier A. Rollin V. Deramecourt T. Lebouvier D. Kapogiannis L. Ferrucci S. Pickering-Brown A. B. Singleton 10.1038/s41598-019-46415-1 http://dx.doi.org/10.1038/s41598-019-46415-1 journal Scientific Reports © 2019, The Author(s) 2045-2322 10.1038/s41598-019-46415-1 Springer 2019-07-22T15:41:12+02:00 2019-07-19T21:57:57+05:30 2019-07-22T15:41:12+02:00 True iText® 5.3.5 ©2000-2012 1T3XT BVBA (AGPL-version) VoR uuid:437db679-1c19-4010-ad85-006017a876a7 uuid:f462efc2-091f-4d5c-85d1-0b790b353481 default 1 converted uuid:c17c90fc-cb83-4199-a839-1335dfb246d9 converted to PDF/A-2b pdfToolbox 2019-07-19T21:58:47+05:30 2 B http://ns.adobe.com/pdf/1.3/ pdf Adobe PDF Schema internal A name object indicating whether the document has been modified to include trapping information Trapped Text http://ns.adobe.com/xap/1.0/mm/ xmpMM XMP Media Management Schema internal UUID based identifier for specific incarnation of a document InstanceID URI internal The common identifier for all versions and renditions of a document. 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