5f945c59134c7c91d3221b94dfdbb611 froimm_a2019m7v10p1695.pdf 81450458cc982b3a53459ebbd4bad90e326b1971 froimm_a2019m7v10p1695.pdf dd4856d8fbaddba8f23794f3534cae508dad4fe62532ef5d596a1ffd68a6c0c2 froimm_a2019m7v10p1695.pdf Title: Regulation of TSHR Expression in the Thyroid and Thymus May Contribute to TSHR Tolerance Failure in Graves' Disease Patients via Two Distinct Mechanisms Subject: Graves' disease (GD) involves the presence of agonistic auto-antibodies against the thyrotropin receptor (TSHR), which are responsible for the clinical symptoms. Keywords: Graves' disease, TSHR, tolerance, splicing isoforms, thymus, thyroid, next-generation sequencing Author: Roger Colobran and Ricardo Pujol-Borrell Creator: LaTeX with hyperref package + hypdvips Producer: dvips + MiKTeX GPL Ghostscript 9.0 CreationDate: Thu Jul 18 11:11:16 2019 CEST ModDate: Thu Jul 22 17:26:11 2021 CEST Tagged: no UserProperties: no Suspects: no Form: none JavaScript: no Pages: 12 Encrypted: no Page size: 595.26 x 779.52 pts Page rot: 0 File size: 1370284 bytes Optimized: yes PDF version: 1.4 name type encoding emb sub uni object ID ------------------------------------ ----------------- ---------------- --- --- --- --------- ALCKDB+HelveticaNeueLTStd-Bd Type 1C Custom yes yes no 312 0 CUMZEL+HelveticaNeueLTStd-Lt Type 1C Custom yes yes no 316 0 VNUKMC+HelveticaNeueLTStd-BdIt Type 1C WinAnsi yes yes no 321 0 NXZMZE+HelveticaNeueLTStd-LtIt Type 1C Custom yes yes no 325 0 IAQFWX+HelveticaNeueLTStd-MdIt Type 1C WinAnsi yes yes no 329 0 IZOBVN+MTSY Type 1C Custom 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Direction: L2R ViewArea: CropBox ViewClip: CropBox PrintArea: CropBox PageClip: CropBox PageLayout: SinglePage PageMode: UseOutlines Language: en Outlines: Item: Title: Regulation of TSHR Expression in the Thyroid and Thymus May Contribute to TSHR Tolerance Failure in Graves' Disease Patients v椀愀 吀眀漀 䐀椀猀琀椀渀挀琀 䴀攀挀栀愀渀椀猀洀猩㸾൥湤潢樍㌴㠠〠潢樍㰼⽁捴楯港䝯呯⽄敳琯獥捴楯渪⸲⽎數琠㌶〠〠刯偡牥湴″㐷‰⁒⽔楴汥⣾＀䤀渀琀爀漀搀甀挀琀椀漀温㸾൥湤潢樍㌴㤠〠潢樍㰼⽁捴楯港䝯呯⽄敳琯獥捴楯渪⸲㐯偡牥湴″㐷‰⁒⽐牥瘠㌵〠〠刯呩瑬攨References Destination: edu.harvard.hul.ois.jhove.module.pdf.PdfSimpleObject@4eb7f003 Children: Item: Title: Introduction Destination: edu.harvard.hul.ois.jhove.module.pdf.PdfSimpleObject@eafc191 Item: Title: Materials and Methods Destination: edu.harvard.hul.ois.jhove.module.pdf.PdfSimpleObject@612fc6eb Children: Item: Title: Patients and Samples Destination: edu.harvard.hul.ois.jhove.module.pdf.PdfSimpleObject@1060b431 Item: Title: DNA and RNA Isolation Destination: edu.harvard.hul.ois.jhove.module.pdf.PdfSimpleObject@612679d6 Item: Title: Genotyping TSHR Polymorphisms Destination: edu.harvard.hul.ois.jhove.module.pdf.PdfSimpleObject@11758f2a Item: Title: Allele-Specific Quantification Using Massive Parallel Sequencing [Next-Generation Sequencing [NGS]] Destination: edu.harvard.hul.ois.jhove.module.pdf.PdfSimpleObject@e720b71 Children: Item: Title: Library Preparation, DNA Sequencing, SNP Calling, and Genotyping Destination: edu.harvard.hul.ois.jhove.module.pdf.PdfSimpleObject@1b26f7b2 Item: Title: Quantification of the Relative Gene Expression by qPCR Destination: edu.harvard.hul.ois.jhove.module.pdf.PdfSimpleObject@491cc5c9 Item: Title: TSHR Detection in Thymocytes and Thymic APCs by Indirect Immunofluorescence Destination: edu.harvard.hul.ois.jhove.module.pdf.PdfSimpleObject@74ad1f1f Item: Title: Statistical Analysis Destination: edu.harvard.hul.ois.jhove.module.pdf.PdfSimpleObject@6a1aab78 Item: Title: Results Destination: edu.harvard.hul.ois.jhove.module.pdf.PdfSimpleObject@462d5aee Children: Item: Title: Analysis of TSHR Transcripts in the Thymus and Thyroid Destination: edu.harvard.hul.ois.jhove.module.pdf.PdfSimpleObject@69b0fd6f Item: Title: NGS Confirms the Thymus-Specific Influence of TSHR Expression by GD-Associated SNPs Destination: edu.harvard.hul.ois.jhove.module.pdf.PdfSimpleObject@757942a1 Item: Title: GD-Associated Intron 1 SNPs Do Not Influence Alternative TSHR Splicing in the Thyroid and Thymus Destination: edu.harvard.hul.ois.jhove.module.pdf.PdfSimpleObject@4a87761d Item: Title: TSHR Is Associated With Both Thymocytes, Macrophages, and Dendritic Cells in the Thymus Destination: edu.harvard.hul.ois.jhove.module.pdf.PdfSimpleObject@66d1af89 Item: Title: Discussion Destination: edu.harvard.hul.ois.jhove.module.pdf.PdfSimpleObject@8646db9 Item: Title: Data Availability Destination: edu.harvard.hul.ois.jhove.module.pdf.PdfSimpleObject@37374a5e Item: Title: Ethics Statement Destination: edu.harvard.hul.ois.jhove.module.pdf.PdfSimpleObject@4671e53b Item: Title: Author Contributions Destination: edu.harvard.hul.ois.jhove.module.pdf.PdfSimpleObject@2db7a79b Item: Title: Funding Destination: edu.harvard.hul.ois.jhove.module.pdf.PdfSimpleObject@6950e31 Item: Title: Acknowledgments Destination: edu.harvard.hul.ois.jhove.module.pdf.PdfSimpleObject@b7dd107 Item: Title: Supplementary Material Destination: edu.harvard.hul.ois.jhove.module.pdf.PdfSimpleObject@42eca56e Item: Title: References Destination: edu.harvard.hul.ois.jhove.module.pdf.PdfSimpleObject@52f759d7 Info: Title: Regulation of TSHR Expression in the Thyroid and Thymus May Contribute to TSHR Tolerance Failure in Graves' Disease Patients via Two Distinct Mechanisms Author: Roger Colobran and Ricardo Pujol-Borrell Subject: Graves' disease (GD) involves the presence of agonistic auto-antibodies against the thyrotropin receptor (TSHR), which are responsible for the clinical symptoms. Keywords: Graves' disease, TSHR, tolerance, splicing isoforms, thymus, thyroid, next-generation sequencing Creator: LaTeX with hyperref package + hypdvips Producer: dvips + MiKTeX GPL Ghostscript 9.0 CreationDate: Thu Jul 18 11:41:16 CEST 2019 ModDate: Thu Jul 22 17:26:11 CEST 2021 ID: 0x9d7d2fa8688f8b9cfc47637679517db0, 0xa9f6069718cf64419756f7fc66606980 Filters: FilterPipeline: FlateDecode FilterPipeline: DCTDecode Images: Image: NisoImageMetadata: FormatName: image/jpg CompressionScheme: JPEG ImageWidth: 2008 ImageHeight: 1506 BitsPerSample: 8 BitsPerSampleUnit: integer Interpolate: true Image: NisoImageMetadata: FormatName: image/jpg CompressionScheme: JPEG ImageWidth: 1772 ImageHeight: 719 BitsPerSample: 8 BitsPerSampleUnit: integer Interpolate: true Image: NisoImageMetadata: FormatName: image/jpg CompressionScheme: JPEG ImageWidth: 1535 ImageHeight: 618 BitsPerSample: 8 BitsPerSampleUnit: integer Interpolate: true Image: NisoImageMetadata: FormatName: image/jpg CompressionScheme: 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2021-07-22T17:26:11+02:00 7f1c3c6a-ab97-11e9-0000-e11bf34aa00e uuid:723dccdf-1ca6-488d-9983-538555f52ee3 application/pdf Regulation of TSHR Expression in the Thyroid and Thymus May Contribute to TSHR Tolerance Failure in Graves' Disease Patients via Two Distinct Mechanisms Roger Colobran and Ricardo Pujol-Borrell Graves' disease (GD) involves the presence of agonistic auto-antibodies against the thyrotropin receptor (TSHR), which are responsible for the clinical symptoms. Graves' disease (GD) involves the presence of agonistic auto-antibodies against the thyrotropin receptor (TSHR), which are responsible for the clinical symptoms. 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