04870ed7ca198e69f6cc2c07a0713e3a 223953.pdf fc8c56934ee195a5540569dd6ba2f358a9b1d711 223953.pdf 747de4970a304474ef6c9bc5beeb077c5d95745535249e5dce751e0a955ad792 223953.pdf Title: Genome-wide association study of eosinophilic granulomatosis with polyangiitis reveals genomic loci stratified by ANCA status Subject: Nature Communications, doi:10.1038/s41467-019-12515-9 Keywords: Author: Paul A Lyons Creator: Springer Producer: iText® 5.3.5 ©2000-2012 1T3XT BVBA (AGPL-version) CreationDate: Tue Nov 5 06:37:11 2019 CET ModDate: Wed Jul 21 11:36:31 2021 CEST Tagged: no UserProperties: no Suspects: no Form: AcroForm JavaScript: no Pages: 13 Encrypted: no Page size: 595.276 x 782.362 pts Page rot: 0 File size: 1489668 bytes Optimized: yes PDF version: 1.6 name type encoding emb sub uni object ID ------------------------------------ ----------------- ---------------- --- --- --- --------- EHLAKJ+AdvOTea1a7398 Type 1C WinAnsi yes yes no 728 0 EHLALJ+AdvOTea1a7398+fb Type 1C Custom yes yes yes 731 0 EHLALK+AdvTTab7e17fd Type 1C WinAnsi yes yes no 733 0 EHLALL+AdvOT9bd21c25.I Type 1C WinAnsi yes yes no 735 0 EHLAMM+AdvOTcb88df00 Type 1C WinAnsi yes yes no 737 0 Arial-BoldMT Type 1C WinAnsi yes no no 739 0 EHLCDF+AdvOTf23bb480 Type 1C WinAnsi yes yes no 741 0 EHLCEG+AdvOTf23bb480+fb Type 1C Custom yes yes yes 743 0 EHLCEH+AdvTTda6f6cb8.B Type 1C WinAnsi yes yes no 745 0 EHLCIG+AdvOT125c650c Type 1C WinAnsi yes yes no 536 0 EHLCIH+AdvOT1ef757c0 Type 1C WinAnsi yes yes no 535 0 EHLCJI+AdvOT1ef757c0+fb Type 1C Custom yes yes yes 533 0 EHLCJJ+AdvOT1ef757c0+20 Type 1C WinAnsi yes yes no 529 0 EHLCJK+AdvOT7d6df7ab.I Type 1C WinAnsi yes yes no 530 0 EHLCKL+AdvOTb65e897d.B Type 1C WinAnsi yes yes no 527 0 EHLCKM+AdvTTab7e17fd+22 Type 1C Custom yes yes no 531 0 EHLCLM+AdvOT1ef757c0+22 Type 1C Custom yes yes yes 517 0 EHLCLN+AdvOTb65e897d.B+fb Type 1C Custom yes yes yes 519 0 EHLCMO+AdvOTe75a9404.I Type 1C WinAnsi yes yes no 521 0 EHLCMP+AdvOTea1a7398+20 Type 1C WinAnsi yes yes no 518 0 EHLFIP+Helvetica Type 1C Custom yes yes no 544 0 EHLGAN+Helvetica-Oblique Type 1C WinAnsi yes yes no 540 0 EHLGBO+Helvetica-Bold Type 1C WinAnsi yes yes no 543 0 EHLGCO+AdvOTcb88df00+20 Type 1C WinAnsi yes yes no 538 0 EHLGGO+AdvOT45bf69de.BI Type 1C WinAnsi yes yes no 546 0 EHLNCG+AdvOT7d6df7ab.I+20 Type 1C WinAnsi yes yes no 548 0 EHLPCK+AdvOTcb88df00+fb Type 1C Custom yes yes yes 549 0 EHLPCL+AdvP4C4E74 Type 1C Custom yes yes yes 550 0 EHLPCM+AdvP4C4E51 Type 1C WinAnsi yes yes no 551 0 EHLPDN+AdvP4C4E59 Type 1C WinAnsi yes yes no 552 0 EHLPDO+AdvOT7d6df7ab.I+22 Type 1C Custom yes yes yes 553 0 EHLPDP+AdvOT7d6df7ab.I+03 Type 1C Custom yes yes yes 554 0 EHLPEA+AdvOT1ef757c0+03 Type 1C Custom yes yes yes 555 0 EHLPIP+AdvOTb65e897d.B+20 Type 1C WinAnsi yes yes no 558 0 EHMBJE+AdvOTf23bb480+20 Type 1C WinAnsi yes yes no 559 0 Jhove (Rel. 1.22.1, 2019-04-17) Date: 2021-07-22 02:39:28 CEST RepresentationInformation: 223953.pdf ReportingModule: PDF-hul, Rel. 1.12.1 (2019-04-17) LastModified: 2021-07-21 12:20:30 CEST Size: 1489668 Format: PDF Version: 1.6 Status: Well-Formed, but not valid SignatureMatches: PDF-hul ID: PDF-HUL-122 ErrorMessage: edu.harvard.hul.ois.jhove.module.pdf.PdfInvalidException: Invalid indirect destination - referenced object 'bm_CR2' cannot be found Offset: 1453505 ID: PDF-HUL-122 ErrorMessage: edu.harvard.hul.ois.jhove.module.pdf.PdfInvalidException: Invalid indirect destination - referenced object 'bm_CR2' cannot be found Offset: 1453505 ID: PDF-HUL-122 ErrorMessage: edu.harvard.hul.ois.jhove.module.pdf.PdfInvalidException: Invalid indirect destination - referenced object 'bm_CR2' cannot be found Offset: 1453505 ID: PDF-HUL-122 ErrorMessage: edu.harvard.hul.ois.jhove.module.pdf.PdfInvalidException: Invalid indirect destination - referenced object 'bm_CR2' cannot be found Offset: 1453505 ID: PDF-HUL-122 ErrorMessage: edu.harvard.hul.ois.jhove.module.pdf.PdfInvalidException: Invalid indirect destination - referenced object 'bm_CR10' cannot be found Offset: 1453505 ID: PDF-HUL-122 ErrorMessage: edu.harvard.hul.ois.jhove.module.pdf.PdfInvalidException: Invalid indirect destination - referenced object 'bm_CR11' cannot be found Offset: 1453505 ID: PDF-HUL-122 ErrorMessage: edu.harvard.hul.ois.jhove.module.pdf.PdfInvalidException: Invalid indirect destination - referenced object 'bm_CR12' cannot be found Offset: 1453505 ID: PDF-HUL-122 ErrorMessage: edu.harvard.hul.ois.jhove.module.pdf.PdfInvalidException: Invalid indirect destination - referenced object 'bm_CR13' cannot be found Offset: 1453505 ID: PDF-HUL-122 ErrorMessage: edu.harvard.hul.ois.jhove.module.pdf.PdfInvalidException: Invalid indirect destination - referenced object 'bm_CR12' cannot be found Offset: 1453505 ID: PDF-HUL-122 ErrorMessage: edu.harvard.hul.ois.jhove.module.pdf.PdfInvalidException: Invalid indirect destination - referenced object 'bm_CR13' cannot be found Offset: 1453505 ID: PDF-HUL-122 ErrorMessage: edu.harvard.hul.ois.jhove.module.pdf.PdfInvalidException: Invalid indirect destination - referenced object 'bm_CR2' cannot be found Offset: 1453505 ID: PDF-HUL-122 ErrorMessage: edu.harvard.hul.ois.jhove.module.pdf.PdfInvalidException: Invalid indirect destination - referenced object 'bm_CR14' cannot be found Offset: 1453505 ID: PDF-HUL-122 ErrorMessage: edu.harvard.hul.ois.jhove.module.pdf.PdfInvalidException: Invalid indirect destination - referenced object 'bm_CR15' cannot be found Offset: 1453505 ID: PDF-HUL-122 ErrorMessage: edu.harvard.hul.ois.jhove.module.pdf.PdfInvalidException: Invalid indirect destination - referenced object 'bm_CR16' cannot be found Offset: 1453505 ID: PDF-HUL-122 ErrorMessage: edu.harvard.hul.ois.jhove.module.pdf.PdfInvalidException: Invalid indirect destination - referenced object 'bm_CR17' cannot be found Offset: 1453505 ID: PDF-HUL-122 ErrorMessage: edu.harvard.hul.ois.jhove.module.pdf.PdfInvalidException: Invalid indirect destination - referenced object 'bm_CR19' cannot be found Offset: 1453505 ID: PDF-HUL-122 ErrorMessage: edu.harvard.hul.ois.jhove.module.pdf.PdfInvalidException: Invalid indirect destination - referenced object 'bm_CR20' cannot be found Offset: 1453505 ID: PDF-HUL-122 ErrorMessage: edu.harvard.hul.ois.jhove.module.pdf.PdfInvalidException: Invalid indirect destination - referenced object 'bm_CR21' cannot be found Offset: 1453505 ID: PDF-HUL-122 ErrorMessage: edu.harvard.hul.ois.jhove.module.pdf.PdfInvalidException: Invalid indirect destination - referenced object 'bm_CR22' cannot be found Offset: 1453505 ID: PDF-HUL-122 ErrorMessage: edu.harvard.hul.ois.jhove.module.pdf.PdfInvalidException: Invalid indirect destination - referenced object 'bm_CR23' cannot be found Offset: 1453505 ID: PDF-HUL-122 ErrorMessage: edu.harvard.hul.ois.jhove.module.pdf.PdfInvalidException: Invalid indirect destination - referenced object 'bm_CR24' cannot be found Offset: 1453505 ID: PDF-HUL-122 ErrorMessage: edu.harvard.hul.ois.jhove.module.pdf.PdfInvalidException: Invalid indirect destination - referenced object 'bm_CR25' cannot be found Offset: 1453505 ID: PDF-HUL-122 ErrorMessage: edu.harvard.hul.ois.jhove.module.pdf.PdfInvalidException: Invalid indirect destination - referenced object 'bm_CR26' cannot be found Offset: 1453505 ID: PDF-HUL-122 ErrorMessage: edu.harvard.hul.ois.jhove.module.pdf.PdfInvalidException: Invalid indirect destination - referenced object 'bm_CR13' cannot be found Offset: 1453505 ID: PDF-HUL-122 ErrorMessage: edu.harvard.hul.ois.jhove.module.pdf.PdfInvalidException: Invalid indirect destination - referenced object 'bm_CR27' cannot be found Offset: 1453505 ID: PDF-HUL-122 ErrorMessage: edu.harvard.hul.ois.jhove.module.pdf.PdfInvalidException: Invalid indirect destination - referenced object 'bm_CR28' cannot be found Offset: 1453505 ID: PDF-HUL-122 ErrorMessage: edu.harvard.hul.ois.jhove.module.pdf.PdfInvalidException: Invalid indirect destination - referenced object 'bm_CR13' cannot be found Offset: 1453505 ID: PDF-HUL-122 ErrorMessage: edu.harvard.hul.ois.jhove.module.pdf.PdfInvalidException: Invalid indirect destination - referenced object 'bm_CR29' cannot be found Offset: 1453505 ID: PDF-HUL-122 ErrorMessage: edu.harvard.hul.ois.jhove.module.pdf.PdfInvalidException: Invalid indirect destination - referenced object 'bm_CR15' cannot be found Offset: 1453505 ID: PDF-HUL-122 ErrorMessage: edu.harvard.hul.ois.jhove.module.pdf.PdfInvalidException: Invalid indirect destination - referenced object 'bm_CR30' cannot be found Offset: 1453505 ID: PDF-HUL-122 ErrorMessage: edu.harvard.hul.ois.jhove.module.pdf.PdfInvalidException: Invalid indirect destination - referenced object 'bm_CR31' cannot be found Offset: 1453505 ID: PDF-HUL-122 ErrorMessage: edu.harvard.hul.ois.jhove.module.pdf.PdfInvalidException: Invalid indirect destination - referenced object 'bm_CR32' cannot be found Offset: 1453505 ID: PDF-HUL-122 ErrorMessage: edu.harvard.hul.ois.jhove.module.pdf.PdfInvalidException: Invalid indirect destination - referenced object 'bm_CR12' cannot be found Offset: 1453505 ID: PDF-HUL-122 ErrorMessage: edu.harvard.hul.ois.jhove.module.pdf.PdfInvalidException: Invalid indirect destination - referenced object 'bm_CR15' cannot be found Offset: 1453505 ID: PDF-HUL-122 ErrorMessage: edu.harvard.hul.ois.jhove.module.pdf.PdfInvalidException: Invalid indirect destination - referenced object 'bm_CR53' cannot be found Offset: 1453505 ID: PDF-HUL-122 ErrorMessage: edu.harvard.hul.ois.jhove.module.pdf.PdfInvalidException: Invalid indirect destination - referenced object 'bm_CR32' cannot be found Offset: 1453505 ID: PDF-HUL-122 ErrorMessage: edu.harvard.hul.ois.jhove.module.pdf.PdfInvalidException: Invalid indirect destination - referenced object 'bm_CR13' cannot be found Offset: 1453505 ID: PDF-HUL-122 ErrorMessage: edu.harvard.hul.ois.jhove.module.pdf.PdfInvalidException: Invalid indirect destination - referenced object 'bm_CR33' cannot be found Offset: 1453505 ID: PDF-HUL-122 ErrorMessage: edu.harvard.hul.ois.jhove.module.pdf.PdfInvalidException: Invalid indirect destination - referenced object 'bm_CR24' cannot be found Offset: 1453505 ID: PDF-HUL-122 ErrorMessage: edu.harvard.hul.ois.jhove.module.pdf.PdfInvalidException: Invalid indirect destination - referenced object 'bm_CR2' cannot be found Offset: 1453505 ID: PDF-HUL-122 ErrorMessage: edu.harvard.hul.ois.jhove.module.pdf.PdfInvalidException: Invalid indirect destination - referenced object 'bm_CR32' cannot be found Offset: 1453505 ID: PDF-HUL-122 ErrorMessage: edu.harvard.hul.ois.jhove.module.pdf.PdfInvalidException: Invalid indirect destination - referenced object 'bm_CR34' cannot be found Offset: 1453505 ID: PDF-HUL-122 ErrorMessage: edu.harvard.hul.ois.jhove.module.pdf.PdfInvalidException: Invalid indirect destination - referenced object 'bm_CR35' cannot be found Offset: 1453505 ID: PDF-HUL-122 ErrorMessage: edu.harvard.hul.ois.jhove.module.pdf.PdfInvalidException: Invalid indirect destination - referenced object 'bm_CR36' cannot be found Offset: 1453505 ID: PDF-HUL-122 ErrorMessage: edu.harvard.hul.ois.jhove.module.pdf.PdfInvalidException: Invalid indirect destination - referenced object 'bm_CR37' cannot be found Offset: 1453505 ID: PDF-HUL-122 ErrorMessage: edu.harvard.hul.ois.jhove.module.pdf.PdfInvalidException: Invalid indirect destination - referenced object 'bm_CR38' cannot be found Offset: 1453505 ID: PDF-HUL-122 ErrorMessage: edu.harvard.hul.ois.jhove.module.pdf.PdfInvalidException: Invalid indirect destination - referenced object 'bm_CR34' cannot be found Offset: 1453505 ID: PDF-HUL-122 ErrorMessage: edu.harvard.hul.ois.jhove.module.pdf.PdfInvalidException: Invalid indirect destination - referenced object 'bm_CR39' cannot be found Offset: 1453505 ID: PDF-HUL-122 ErrorMessage: edu.harvard.hul.ois.jhove.module.pdf.PdfInvalidException: Invalid indirect destination - referenced object 'bm_CR40' cannot be found Offset: 1453505 ID: PDF-HUL-122 ErrorMessage: edu.harvard.hul.ois.jhove.module.pdf.PdfInvalidException: Invalid indirect destination - referenced object 'bm_CR41' cannot be found Offset: 1453505 ID: PDF-HUL-122 ErrorMessage: edu.harvard.hul.ois.jhove.module.pdf.PdfInvalidException: Invalid indirect destination - referenced object 'bm_CR42' cannot be found Offset: 1453505 ID: PDF-HUL-122 ErrorMessage: edu.harvard.hul.ois.jhove.module.pdf.PdfInvalidException: Invalid indirect destination - referenced object 'bm_CR43' cannot be found Offset: 1453505 ID: PDF-HUL-122 ErrorMessage: edu.harvard.hul.ois.jhove.module.pdf.PdfInvalidException: Invalid indirect destination - referenced object 'bm_CR44' cannot be found Offset: 1453505 ID: PDF-HUL-122 ErrorMessage: edu.harvard.hul.ois.jhove.module.pdf.PdfInvalidException: Invalid indirect destination - referenced object 'bm_CR10' cannot be found Offset: 1453505 ID: PDF-HUL-122 ErrorMessage: edu.harvard.hul.ois.jhove.module.pdf.PdfInvalidException: Invalid indirect destination - referenced object 'bm_CR11' cannot be found Offset: 1453505 ID: PDF-HUL-122 ErrorMessage: edu.harvard.hul.ois.jhove.module.pdf.PdfInvalidException: Invalid indirect destination - referenced object 'bm_CR12' cannot be found Offset: 1453505 ID: PDF-HUL-122 ErrorMessage: edu.harvard.hul.ois.jhove.module.pdf.PdfInvalidException: Invalid indirect destination - referenced object 'bm_CR13' cannot be found Offset: 1453505 ID: PDF-HUL-122 ErrorMessage: edu.harvard.hul.ois.jhove.module.pdf.PdfInvalidException: Invalid indirect destination - referenced object 'bm_CR11' cannot be found Offset: 1453505 ID: PDF-HUL-122 ErrorMessage: edu.harvard.hul.ois.jhove.module.pdf.PdfInvalidException: Invalid indirect destination - referenced object 'bm_CR45' cannot be found Offset: 1453505 ID: PDF-HUL-122 ErrorMessage: edu.harvard.hul.ois.jhove.module.pdf.PdfInvalidException: Invalid indirect destination - referenced object 'bm_CR46' cannot be found Offset: 1453505 ID: PDF-HUL-122 ErrorMessage: edu.harvard.hul.ois.jhove.module.pdf.PdfInvalidException: Invalid indirect destination - referenced object 'bm_CR47' cannot be found Offset: 1453505 ID: PDF-HUL-122 ErrorMessage: edu.harvard.hul.ois.jhove.module.pdf.PdfInvalidException: Invalid indirect destination - referenced object 'bm_CR48' cannot be found Offset: 1453505 ID: PDF-HUL-122 ErrorMessage: edu.harvard.hul.ois.jhove.module.pdf.PdfInvalidException: Invalid indirect destination - referenced object 'bm_CR30' cannot be found Offset: 1453505 ID: PDF-HUL-122 ErrorMessage: edu.harvard.hul.ois.jhove.module.pdf.PdfInvalidException: Invalid indirect destination - referenced object 'bm_CR49' cannot be found Offset: 1453505 ID: PDF-HUL-122 ErrorMessage: edu.harvard.hul.ois.jhove.module.pdf.PdfInvalidException: Invalid indirect destination - referenced object 'bm_CR50' cannot be found Offset: 1453505 ID: PDF-HUL-122 ErrorMessage: edu.harvard.hul.ois.jhove.module.pdf.PdfInvalidException: Invalid indirect destination - referenced object 'bm_CR51' cannot be found Offset: 1453505 ID: PDF-HUL-122 ErrorMessage: edu.harvard.hul.ois.jhove.module.pdf.PdfInvalidException: Invalid indirect destination - referenced object 'bm_CR52' cannot be found Offset: 1453505 ID: PDF-HUL-122 ErrorMessage: edu.harvard.hul.ois.jhove.module.pdf.PdfInvalidException: Invalid indirect destination - referenced object 'bm_CR13' cannot be found Offset: 1453505 MIMEtype: application/pdf Profile: Linearized PDF PDFMetadata: Objects: 0 FreeObjects: 1 IncrementalUpdates: 0 DocumentCatalog: PageLayout: SinglePage PageMode: UseOutlines Language: EN Outlines: Item: Title: Genome-wide association study of eosinophilic granulomatosis with polyangiitis reveals genomic loci stratified by ANCA status Destination: edu.harvard.hul.ois.jhove.module.pdf.PdfSimpleObject@66d1af89 Children: Item: Title: Results Destination: edu.harvard.hul.ois.jhove.module.pdf.PdfSimpleObject@8646db9 Children: Item: Title: The genetic contribution to EGPA Destination: edu.harvard.hul.ois.jhove.module.pdf.PdfSimpleObject@37374a5e Item: Title: Conditional false discovery rate analysis finds further loci Destination: edu.harvard.hul.ois.jhove.module.pdf.PdfSimpleObject@4671e53b Item: Title: Clinically and genetically distinct EGPA subsets Destination: edu.harvard.hul.ois.jhove.module.pdf.PdfSimpleObject@2db7a79b Item: Title: Candidate genes and EGPA pathogenesis Destination: edu.harvard.hul.ois.jhove.module.pdf.PdfSimpleObject@6950e31 Item: Title: BCL2L11 and MORRBID Destination: edu.harvard.hul.ois.jhove.module.pdf.PdfSimpleObject@b7dd107 Item: Title: TSLP Destination: edu.harvard.hul.ois.jhove.module.pdf.PdfSimpleObject@42eca56e Item: Title: GPA33 Destination: edu.harvard.hul.ois.jhove.module.pdf.PdfSimpleObject@52f759d7 Item: Title: LPP Destination: edu.harvard.hul.ois.jhove.module.pdf.PdfSimpleObject@7cbd213e Item: Title: C5orf56-IRF1-IL5 Destination: edu.harvard.hul.ois.jhove.module.pdf.PdfSimpleObject@192d3247 Item: Title: BACH2 Destination: edu.harvard.hul.ois.jhove.module.pdf.PdfSimpleObject@3ecd23d9 Item: Title: CDK6 Destination: edu.harvard.hul.ois.jhove.module.pdf.PdfSimpleObject@569cfc36 Item: Title: 10p14 intergenic region and GATA3 Destination: edu.harvard.hul.ois.jhove.module.pdf.PdfSimpleObject@43bd930a Item: Title: HLA Destination: edu.harvard.hul.ois.jhove.module.pdf.PdfSimpleObject@33723e30 Item: Title: Mendelian randomisation implicates eosinophils in aetiology Destination: edu.harvard.hul.ois.jhove.module.pdf.PdfSimpleObject@64f6106c Item: Title: Discussion Destination: edu.harvard.hul.ois.jhove.module.pdf.PdfSimpleObject@553a3d88 Item: Title: Methods Destination: edu.harvard.hul.ois.jhove.module.pdf.PdfSimpleObject@7a30d1e6 Children: Item: Title: Inclusion criteria Destination: edu.harvard.hul.ois.jhove.module.pdf.PdfSimpleObject@5891e32e Item: Title: Subjects Destination: edu.harvard.hul.ois.jhove.module.pdf.PdfSimpleObject@cb0ed20 Item: Title: Genotyping and quality control (QC) Destination: edu.harvard.hul.ois.jhove.module.pdf.PdfSimpleObject@8e24743 Item: Title: Replication cohort genotyping Destination: edu.harvard.hul.ois.jhove.module.pdf.PdfSimpleObject@74a10858 Item: Title: Association testing on the directly genotyped data Destination: edu.harvard.hul.ois.jhove.module.pdf.PdfSimpleObject@23fe1d71 Item: Title: Pre-phasing and imputation Destination: edu.harvard.hul.ois.jhove.module.pdf.PdfSimpleObject@28ac3dc3 Item: Title: Association testing following imputation Destination: edu.harvard.hul.ois.jhove.module.pdf.PdfSimpleObject@32eebfca Item: Title: Analysis stratified by ANCA Destination: edu.harvard.hul.ois.jhove.module.pdf.PdfSimpleObject@4e718207 Item: Title: Leveraging association statistics from related traits Destination: edu.harvard.hul.ois.jhove.module.pdf.PdfSimpleObject@1d371b2d Item: Title: Replication cohort analysis Destination: edu.harvard.hul.ois.jhove.module.pdf.PdfSimpleObject@543c6f6d Item: Title: Fine-mapping Destination: edu.harvard.hul.ois.jhove.module.pdf.PdfSimpleObject@13eb8acf Item: Title: HLA imputation Destination: edu.harvard.hul.ois.jhove.module.pdf.PdfSimpleObject@51c8530f Item: Title: Narrow-sense heritability estimation Destination: edu.harvard.hul.ois.jhove.module.pdf.PdfSimpleObject@7403c468 Item: Title: Promoter enhancer interaction mining Destination: edu.harvard.hul.ois.jhove.module.pdf.PdfSimpleObject@43738a82 Item: Title: Data mining Destination: edu.harvard.hul.ois.jhove.module.pdf.PdfSimpleObject@c81cdd1 Item: Title: Associations of clinical characteristic with ANCA status Destination: edu.harvard.hul.ois.jhove.module.pdf.PdfSimpleObject@1fc2b765 Item: Title: Mendelian randomisation Destination: edu.harvard.hul.ois.jhove.module.pdf.PdfSimpleObject@75881071 Item: Title: Study approval Destination: edu.harvard.hul.ois.jhove.module.pdf.PdfSimpleObject@2a70a3d8 Item: Title: Reporting summary Destination: edu.harvard.hul.ois.jhove.module.pdf.PdfSimpleObject@289d1c02 Item: Title: Data availability Destination: edu.harvard.hul.ois.jhove.module.pdf.PdfSimpleObject@22eeefeb Item: Title: References Destination: edu.harvard.hul.ois.jhove.module.pdf.PdfSimpleObject@17d0685f Item: Title: Acknowledgements Destination: edu.harvard.hul.ois.jhove.module.pdf.PdfSimpleObject@3891771e Item: Title: Author contributions Destination: edu.harvard.hul.ois.jhove.module.pdf.PdfSimpleObject@78ac1102 Item: Title: Competing interests Destination: edu.harvard.hul.ois.jhove.module.pdf.PdfSimpleObject@2de8284b Item: Title: Additional information Destination: edu.harvard.hul.ois.jhove.module.pdf.PdfSimpleObject@396e2f39 Filters: FilterPipeline: FlateDecode FilterPipeline: DCTDecode Images: Image: NisoImageMetadata: FormatName: image/png ImageWidth: 883 ImageHeight: 344 ColorSpace: RGB BitsPerSample: 8 BitsPerSampleUnit: integer Filter: FlateDecode Intent: Perceptual Image: NisoImageMetadata: FormatName: image/png ImageWidth: 884 ImageHeight: 385 ColorSpace: RGB BitsPerSample: 8 BitsPerSampleUnit: integer Filter: FlateDecode Intent: Perceptual Image: NisoImageMetadata: FormatName: image/png ImageWidth: 878 ImageHeight: 385 ColorSpace: RGB BitsPerSample: 8 BitsPerSampleUnit: integer Filter: FlateDecode Intent: Perceptual Image: NisoImageMetadata: FormatName: image/jpg CompressionScheme: JPEG ImageWidth: 703 ImageHeight: 631 ColorSpace: CMYK BitsPerSample: 8 BitsPerSampleUnit: integer Image: NisoImageMetadata: FormatName: image/jpg CompressionScheme: JPEG ImageWidth: 703 ImageHeight: 631 ColorSpace: CMYK BitsPerSample: 8 BitsPerSampleUnit: integer Image: NisoImageMetadata: FormatName: image/jpg CompressionScheme: JPEG ImageWidth: 710 ImageHeight: 629 ColorSpace: CMYK BitsPerSample: 8 BitsPerSampleUnit: integer Image: NisoImageMetadata: FormatName: image/jpg CompressionScheme: JPEG ImageWidth: 714 ImageHeight: 629 ColorSpace: CMYK BitsPerSample: 8 BitsPerSampleUnit: integer Image: NisoImageMetadata: FormatName: image/png ImageWidth: 747 ImageHeight: 486 ColorSpace: RGB BitsPerSample: 8 BitsPerSampleUnit: integer Filter: FlateDecode Intent: Perceptual Image: NisoImageMetadata: FormatName: image/png ImageWidth: 1100 ImageHeight: 90 ColorSpace: black is zero BitsPerSample: 1 BitsPerSampleUnit: integer Filter: FlateDecode Fonts: Type1: Font: BaseFont: EHLCLM+AdvOT1ef757c0+22 FontSubset: true FirstChar: 1 LastChar: 1 FontDescriptor: FontName: EHLCLM+AdvOT1ef757c0+22 Flags: Symbolic FontBBox: -135, -166, 697, 916 FontFile3: true EncodingDictionary: Differences: true ToUnicode: true Font: BaseFont: EHLCMP+AdvOTea1a7398+20 FontSubset: true FirstChar: 134 LastChar: 146 FontDescriptor: FontName: EHLCMP+AdvOTea1a7398+20 Flags: Nonsymbolic FontBBox: -93, -197, 843, 791 FontFile3: true Encoding: WinAnsiEncoding Font: BaseFont: EHLCLN+AdvOTb65e897d.B+fb FontSubset: true FirstChar: 1 LastChar: 1 FontDescriptor: FontName: EHLCLN+AdvOTb65e897d.B+fb Flags: Symbolic FontBBox: 0, -10, 843, 697 FontFile3: true EncodingDictionary: Differences: true ToUnicode: true Font: BaseFont: EHLCMO+AdvOTe75a9404.I FontSubset: true FirstChar: 78 LastChar: 110 FontDescriptor: FontName: EHLCMO+AdvOTe75a9404.I Flags: Nonsymbolic FontBBox: -83, -197, 1020, 906 FontFile3: true Encoding: WinAnsiEncoding Font: BaseFont: EHLCKL+AdvOTb65e897d.B FontSubset: true FirstChar: 45 LastChar: 121 FontDescriptor: FontName: EHLCKL+AdvOTb65e897d.B Flags: Serif, Nonsymbolic FontBBox: -20, -250, 968, 854 FontFile3: true Encoding: WinAnsiEncoding Font: BaseFont: EHLCJJ+AdvOT1ef757c0+20 FontSubset: true FirstChar: 145 LastChar: 150 FontDescriptor: FontName: EHLCJJ+AdvOT1ef757c0+20 Flags: Nonsymbolic FontBBox: -135, -187, 1010, 833 FontFile3: true Encoding: WinAnsiEncoding Font: BaseFont: EHLCJK+AdvOT7d6df7ab.I FontSubset: true FirstChar: 40 LastChar: 120 FontDescriptor: FontName: EHLCJK+AdvOT7d6df7ab.I Flags: Nonsymbolic FontBBox: -135, -250, 1000, 854 FontFile3: true Encoding: WinAnsiEncoding Font: BaseFont: EHLCKM+AdvTTab7e17fd+22 FontSubset: true FirstChar: 21 LastChar: 21 FontDescriptor: FontName: EHLCKM+AdvTTab7e17fd+22 Flags: Nonsymbolic FontBBox: -156, -218, 937, 947 FontFile3: true EncodingDictionary: BaseEncoding: WinAnsiEncoding Differences: true Font: BaseFont: EHLCJI+AdvOT1ef757c0+fb FontSubset: true FirstChar: 1 LastChar: 3 FontDescriptor: FontName: EHLCJI+AdvOT1ef757c0+fb Flags: Symbolic FontBBox: 0, -10, 781, 708 FontFile3: true EncodingDictionary: Differences: true ToUnicode: true Font: BaseFont: EHLCIH+AdvOT1ef757c0 FontSubset: true FirstChar: 37 LastChar: 237 FontDescriptor: FontName: EHLCIH+AdvOT1ef757c0 Flags: Serif, Nonsymbolic FontBBox: -20, -250, 947, 854 FontFile3: true Encoding: WinAnsiEncoding Font: BaseFont: EHLAKJ+AdvOTea1a7398 FontSubset: true FirstChar: 35 LastChar: 246 FontDescriptor: FontName: EHLAKJ+AdvOTea1a7398 Flags: Nonsymbolic FontBBox: -31, -197, 979, 906 FontFile3: true Encoding: WinAnsiEncoding Font: BaseFont: EHLCIG+AdvOT125c650c FontSubset: true FirstChar: 69 LastChar: 69 FontDescriptor: FontName: EHLCIG+AdvOT125c650c Flags: Nonsymbolic FontBBox: -31, -197, 979, 906 FontFile3: true Encoding: WinAnsiEncoding Font: BaseFont: EHLGCO+AdvOTcb88df00+20 FontSubset: true FirstChar: 135 LastChar: 135 FontDescriptor: FontName: EHLGCO+AdvOTcb88df00+20 Flags: Nonsymbolic FontBBox: -104, -197, 864, 791 FontFile3: true Encoding: WinAnsiEncoding Font: BaseFont: EHLALJ+AdvOTea1a7398+fb FontSubset: true FirstChar: 1 LastChar: 3 FontDescriptor: FontName: EHLALJ+AdvOTea1a7398+fb Flags: Symbolic FontBBox: 0, -197, 750, 791 FontFile3: true EncodingDictionary: Differences: true ToUnicode: true Font: BaseFont: EHLGAN+Helvetica-Oblique FontSubset: true FirstChar: 45 LastChar: 114 FontDescriptor: FontName: EHLGAN+Helvetica-Oblique Flags: Nonsymbolic, Italic FontBBox: -170, -225, 1116, 931 FontFile3: true Encoding: WinAnsiEncoding Font: BaseFont: EHLALK+AdvTTab7e17fd FontSubset: true FirstChar: 43 LastChar: 61 FontDescriptor: FontName: EHLALK+AdvTTab7e17fd Flags: Nonsymbolic FontBBox: -156, -250, 1072, 947 FontFile3: true Encoding: WinAnsiEncoding Font: BaseFont: EHLALL+AdvOT9bd21c25.I FontSubset: true FirstChar: 45 LastChar: 114 FontDescriptor: FontName: EHLALL+AdvOT9bd21c25.I Flags: Nonsymbolic FontBBox: -83, -197, 1010, 906 FontFile3: true Encoding: WinAnsiEncoding Font: BaseFont: EHLGBO+Helvetica-Bold FontSubset: true FirstChar: 97 LastChar: 100 FontDescriptor: FontName: EHLGBO+Helvetica-Bold Flags: Nonsymbolic, ForceBold FontBBox: -170, -228, 1003, 962 FontFile3: true Encoding: WinAnsiEncoding Font: BaseFont: EHLFIP+Helvetica FontSubset: true FirstChar: 21 LastChar: 150 FontDescriptor: FontName: EHLFIP+Helvetica Flags: Nonsymbolic FontBBox: -166, -225, 1000, 931 FontFile3: true EncodingDictionary: BaseEncoding: WinAnsiEncoding Differences: true Font: BaseFont: EHLAMM+AdvOTcb88df00 FontSubset: true FirstChar: 37 LastChar: 215 FontDescriptor: FontName: EHLAMM+AdvOTcb88df00 Flags: Nonsymbolic FontBBox: -41, -197, 968, 906 FontFile3: true Encoding: WinAnsiEncoding Font: BaseFont: EHLGGO+AdvOT45bf69de.BI FontSubset: true FirstChar: 49 LastChar: 84 FontDescriptor: FontName: EHLGGO+AdvOT45bf69de.BI Flags: Nonsymbolic FontBBox: -135, -250, 1010, 864 FontFile3: true Encoding: WinAnsiEncoding Font: BaseFont: Arial-BoldMT FirstChar: 0 LastChar: 255 FontDescriptor: FontName: Arial-BoldMT Flags: Nonsymbolic FontBBox: -628, -376, 2000, 1010 FontFile3: true Encoding: WinAnsiEncoding Font: BaseFont: EHLNCG+AdvOT7d6df7ab.I+20 FontSubset: true FirstChar: 150 LastChar: 150 FontDescriptor: FontName: EHLNCG+AdvOT7d6df7ab.I+20 Flags: Nonsymbolic FontBBox: -156, -187, 1000, 822 FontFile3: true Encoding: WinAnsiEncoding Font: BaseFont: EHLCDF+AdvOTf23bb480 FontSubset: true FirstChar: 35 LastChar: 252 FontDescriptor: FontName: EHLCDF+AdvOTf23bb480 Flags: Nonsymbolic FontBBox: -31, -197, 968, 916 FontFile3: true Encoding: WinAnsiEncoding Font: BaseFont: EHLPCK+AdvOTcb88df00+fb FontSubset: true FirstChar: 1 LastChar: 1 FontDescriptor: FontName: EHLPCK+AdvOTcb88df00+fb Flags: Symbolic FontBBox: 0, -197, 895, 791 FontFile3: true EncodingDictionary: Differences: true ToUnicode: true Font: BaseFont: EHLPCL+AdvP4C4E74 FontSubset: true FirstChar: 2 LastChar: 240 FontDescriptor: FontName: EHLPCL+AdvP4C4E74 Flags: Symbolic FontBBox: -20, -958, 1114, 770 FontFile3: true EncodingDictionary: Differences: true ToUnicode: true Font: BaseFont: EHLCEG+AdvOTf23bb480+fb FontSubset: true FirstChar: 1 LastChar: 3 FontDescriptor: FontName: EHLCEG+AdvOTf23bb480+fb Flags: Symbolic FontBBox: 0, -197, 718, 791 FontFile3: true EncodingDictionary: Differences: true ToUnicode: true Font: BaseFont: EHLPCM+AdvP4C4E51 FontSubset: true FirstChar: 59 LastChar: 59 FontDescriptor: FontName: EHLPCM+AdvP4C4E51 Flags: Nonsymbolic FontBBox: -31, -239, 1041, 750 FontFile3: true Encoding: WinAnsiEncoding Font: BaseFont: EHLPDN+AdvP4C4E59 FontSubset: true FirstChar: 35 LastChar: 35 FontDescriptor: FontName: EHLPDN+AdvP4C4E59 Flags: Nonsymbolic FontBBox: -31, -250, 1000, 750 FontFile3: true Encoding: WinAnsiEncoding Font: BaseFont: EHLCEH+AdvTTda6f6cb8.B FontSubset: true FirstChar: 48 LastChar: 57 FontDescriptor: FontName: EHLCEH+AdvTTda6f6cb8.B Flags: Nonsymbolic FontBBox: -72, -218, 895, 927 FontFile3: true Encoding: WinAnsiEncoding Font: BaseFont: EHLPDO+AdvOT7d6df7ab.I+22 FontSubset: true FirstChar: 1 LastChar: 1 FontDescriptor: FontName: EHLPDO+AdvOT7d6df7ab.I+22 Flags: Symbolic FontBBox: -156, -166, 750, 916 FontFile3: true EncodingDictionary: Differences: true ToUnicode: true Font: BaseFont: EHLPDP+AdvOT7d6df7ab.I+03 FontSubset: true FirstChar: 1 LastChar: 1 FontDescriptor: FontName: EHLPDP+AdvOT7d6df7ab.I+03 Flags: Symbolic FontBBox: -62, -270, 906, 781 FontFile3: true EncodingDictionary: Differences: true ToUnicode: true Font: BaseFont: EHLPEA+AdvOT1ef757c0+03 FontSubset: true FirstChar: 1 LastChar: 3 FontDescriptor: FontName: EHLPEA+AdvOT1ef757c0+03 Flags: Symbolic FontBBox: -125, -270, 854, 791 FontFile3: true EncodingDictionary: Differences: true ToUnicode: true Font: BaseFont: EHLPIP+AdvOTb65e897d.B+20 FontSubset: true FirstChar: 146 LastChar: 146 FontDescriptor: FontName: EHLPIP+AdvOTb65e897d.B+20 Flags: Nonsymbolic FontBBox: -125, -177, 1052, 822 FontFile3: true Encoding: WinAnsiEncoding Font: BaseFont: EHMBJE+AdvOTf23bb480+20 FontSubset: true FirstChar: 146 LastChar: 150 FontDescriptor: FontName: EHMBJE+AdvOTf23bb480+20 Flags: Nonsymbolic FontBBox: -93, -197, 843, 791 FontFile3: true Encoding: WinAnsiEncoding XMP: application/pdf doi:10.1038/s41467-019-12515-9 Genome-wide association study of eosinophilic granulomatosis with polyangiitis reveals genomic loci stratified by ANCA status Paul A Lyons James E Peters Federico Alberici James Liley Richard M. R. Coulson William Astle Chiara Baldini Francesco Bonatti Maria C Cid Heather Elding Giacomo Emmi Jörg Epplen Loïc Guillevin David R. W. Jayne Tao Jiang Iva Gunnarsson Peter Lamprecht Stephen Leslie Mark A. Little Davide Martorana Frank Moosig Thomas Neumann Sophie Ohlsson Stefanie Quickert Giuseppe A. Ramirez Barbara Rewerska Georg Schett Renato A. Sinico Wojciech Szczeklik Vladimir Tesar Damjan Vukcevic Mohammed Akil Jonathan Barratt Neil Basu Adam S. Butterworth Ian Bruce Michael Clarkson Niall Conlon Bhaskar DasGupta Timothy W. R. Doulton Georgina Espígol-Frigolé Oliver Flossmann Armando Gabrielli Jolanta Gasior Gina Gregorini Giuseppe Guida José Hernández-Rodríguez Zdenka Hruskova Amy Hudson Ann Knight Peter Lanyon Raashid Luqmani Malgorzata Magliano Angelo A. Manfredi Christopher Marguerie Federica Maritati Chiara Marvisi Neil J. McHugh Eamonn Molloy Allan Motyer Chetan Mukhtyar Leonid Padyukov Alberto Pesci Sergio Prieto-Gonzalez Marc Ramentol-Sintas Petra Reis Dario Roccatello Patrizia Rovere-Querini Carlo Salvarani Francesca Santarsia Roser Solans-Laque Nicole Soranzo Jo Taylor Julie Wessels Jochen Zwerina Benjamin Terrier Richard A Watts Augusto Vaglio Julia U Holle Chris Wallace Kenneth G. C. Smith Springer US Nature Communications, doi:10.1038/s41467-019-12515-9 10.1038/s41467-019-12515-9 http://dx.doi.org/10.1038/s41467-019-12515-9 journal Nature Communications © 2019, The Author(s) 2041-1723 10.1038/s41467-019-12515-9 springer.com springerlink.com 2010-04-23 True 10.1038/s41467-019-12515-9 springer.com springerlink.com Springer 2021-07-21T11:36:31+02:00 2019-11-05T11:07:11+05:30 2021-07-21T11:36:31+02:00 True iText® 5.3.5 ©2000-2012 1T3XT BVBA (AGPL-version) VoR uuid:a834a874-b70c-4032-ade9-0f07d2148987 uuid:d2e8ff24-db29-4a1a-af2c-bb8c85aaf868 default 1 converted uuid:be0a1edd-bae9-4339-8b91-5856bc9e4e2b converted to PDF/A-2b pdfToolbox 2019-11-05T11:08:06+05:30 James E Peters http://orcid.org/0000-0002-9415-3440 William Astle http://orcid.org/0000-0001-8866-6672 Giacomo Emmi http://orcid.org/0000-0001-9575-8321 Sophie Ohlsson http://orcid.org/0000-0002-5253-1650 Vladimir Tesar http://orcid.org/0000-0001-6982-0689 Damjan Vukcevic http://orcid.org/0000-0001-7780-9586 Richard A Watts http://orcid.org/0000-0002-2846-4769 http://ns.adobe.com/pdf/1.3/ pdf Adobe PDF Schema internal A name object indicating whether the document has been modified to include trapping information Trapped Text http://ns.adobe.com/pdfx/1.3/ pdfx pdfx internal ID of PDF/X standard GTS_PDFXVersion Text internal Conformance level of PDF/X standard GTS_PDFXConformance Text internal Company creating the PDF Company Text internal Date when document was last modified SourceModified Text external Mirrors crossmark:CrosMarkDomains CrossMarkDomains Seq Text internal Mirrors crossmark:DOI doi Text http://ns.adobe.com/xap/1.0/mm/ xmpMM XMP Media Management Schema internal UUID based identifier for specific incarnation of a document InstanceID URI internal The common identifier for all versions and renditions of a document. OriginalDocumentID URI http://www.aiim.org/pdfa/ns/id/ pdfaid PDF/A ID Schema internal Part of PDF/A standard part Integer internal Amendment of PDF/A standard amd Text internal Conformance level of PDF/A standard conformance Text http://crossref.org/crossmark/1.0/ crossmark crossmark internal CrossMarkDomains CrossMarkDomains Seq Text internal CrossmarkDomainExclusive CrossmarkDomainExclusive Text internal Usual same as prism:doi DOI Text external The date when a publication was published. MajorVersionDate Text http://prismstandard.org/namespaces/basic/2.0/ prism Prism external The aggregation type specifies the unit of aggregation for a content collection. Comment PRISM recommends that the PRISM Aggregation Type Controlled Vocabulary be used to provide values for this element. Note: PRISM recommends against the use of the #other value currently allowed in this controlled vocabulary. In lieu of using #other please reach out to the PRISM group at info@prismstandard.org to request addition of your term to the Aggregation Type Controlled Vocabulary. aggregationType Text external Copyright copyright Text external The Digital Object Identifier for the article. The DOI may also be used as the dc:identifier. If used as a dc:identifier, the URI form should be captured, and the bare identifier should also be captured using prism:doi. If an alternate unique identifier is used as the required dc:identifier, then the DOI should be specified as a bare identifier within prism:doi only. If the URL associated with a DOI is to be specified, then prism:url may be used in conjunction with prism:doi in order to provide the service endpoint (i.e. the URL). doi Text external ISSN for an electronic version of the issue in which the resource occurs. Permits publishers to include a second ISSN, identifying an electronic version of the issue in which the resource occurs (therefore e(lectronic)Issn. If used, prism:eIssn MUST contain the ISSN of the electronic version. See prism:issn. issn Text external Title of the magazine, or other publication, in which a resource was/will be published. Typically this will be used to provide the name of the magazine an article appeared in as metadata for the article, along with information such as the article title, the publisher, volume, number, and cover date. Note: Publication name can be used to differentiate between a print magazine and the online version if the names are different such as “magazine” and “magazine.com.” publicationName Text external This element provides the url for an article or unit of content. The attribute platform is optionally allowed for situations in which multiple URLs must be specified. PRISM recommends that a subset of the PCV platform values, namely “mobile” and “web”, be used in conjunction with this element. NOTE: PRISM recommends against the use of the #other value allowed in the PRISM Platform controlled vocabulary. In lieu of using #other please reach out to the PRISM group at prism-wg@yahoogroups.com to request addition of your term to the Platform Controlled Vocabulary. url Text http://springernature.com/ns/xmpExtensions/2.0/ sn Springer Nature ORCID Schema external Author information: contains the name of each author and his/her ORCID (ORCiD: Open Researcher and Contributor ID). An ORCID is a persistent identifier (a non-proprietary alphanumeric code) to uniquely identify scientific and other academic authors. authorInfo Bag AuthorInformation Specifies the types of author information: name and ORCID of an author. http://springernature.com/ns/xmpExtensions/2.0/authorInfo/ author AuthorInformation Gives the name of an author. name Text Gives the ORCID of an author. orcid URI http://www.niso.org/schemas/jav/1.0/ jav NISO external Values for Journal Article Version are one of the following: AO = Author’s Original SMUR = Submitted Manuscript Under Review AM = Accepted Manuscript P = Proof VoR = Version of Record CVoR = Corrected Version of Record EVoR = Enhanced Version of Record journal_article_version Closed Choice of Text Pages: Page: Label: 1 Annotations: Annotation: Subtype: Link Rect: 71, 43, 129, 51 Flags: Print AppearanceDictionary: true Annotation: Subtype: Link Rect: 369, 23, 485, 30 Flags: Print AppearanceDictionary: true Annotation: Subtype: Link Rect: 547, 23, 551, 30 Flags: Print AppearanceDictionary: true Thumb: true Page: Label: 2 Annotations: Annotation: Subtype: Link Rect: 190, 673, 193, 681 Flags: Print AppearanceDictionary: true Destination: 58 Annotation: Subtype: Link Rect: 195, 673, 198, 681 Flags: Print AppearanceDictionary: true Destination: null Annotation: Subtype: Link Rect: 73, 642, 77, 649 Flags: Print AppearanceDictionary: true Destination: 58 Annotation: Subtype: Link Rect: 167, 590, 171, 597 Flags: Print AppearanceDictionary: true Destination: null Annotation: Subtype: Link Rect: 57, 569, 60, 576 Flags: Print AppearanceDictionary: true Destination: 58 Annotation: Subtype: Link Rect: 248, 516, 252, 524 Flags: Print AppearanceDictionary: true Destination: 58 Annotation: Subtype: Link Rect: 256, 516, 259, 524 Flags: Print AppearanceDictionary: true Destination: 58 Annotation: Subtype: Link Rect: 264, 506, 268, 513 Flags: Print AppearanceDictionary: true Destination: null Annotation: Subtype: Link Rect: 162, 454, 165, 461 Flags: Print AppearanceDictionary: true Destination: 58 Annotation: Subtype: Link Rect: 167, 454, 171, 461 Flags: Print AppearanceDictionary: true Destination: 58 Annotation: Subtype: Link Rect: 109, 262, 114, 272 Flags: Print AppearanceDictionary: true Destination: 1 Annotation: Subtype: Link Rect: 285, 255, 289, 263 Flags: Print AppearanceDictionary: true Destination: null Annotation: Subtype: Link Rect: 384, 576, 389, 585 Flags: Print AppearanceDictionary: true Destination: 9 Annotation: Subtype: Link Rect: 521, 576, 526, 585 Flags: Print AppearanceDictionary: true Destination: 9 Annotation: Subtype: Link Rect: 462, 471, 467, 481 Flags: Print AppearanceDictionary: true Destination: 9 Annotation: Subtype: Link Rect: 405, 443, 409, 451 Flags: Print AppearanceDictionary: true Destination: 58 Annotation: Subtype: Link Rect: 418, 370, 425, 378 Flags: Print AppearanceDictionary: true Destination: null Annotation: Subtype: Link Rect: 427, 370, 434, 378 Flags: Print AppearanceDictionary: true Destination: null Annotation: Subtype: Link Rect: 344, 297, 351, 305 Flags: Print AppearanceDictionary: true Destination: null Annotation: Subtype: Link Rect: 344, 266, 352, 273 Flags: Print AppearanceDictionary: true Destination: null Annotation: Subtype: Link Rect: 420, 252, 425, 261 Flags: Print AppearanceDictionary: true Destination: 9 Annotation: Subtype: Link Rect: 436, 23, 551, 30 Flags: Print AppearanceDictionary: true Thumb: true Page: Label: 3 Annotations: Annotation: Subtype: Link Rect: 255, 77, 258, 85 Flags: Print AppearanceDictionary: true Destination: 58 Annotation: Subtype: Link Rect: 491, 378, 496, 382 Flags: Print AppearanceDictionary: true Destination: null Annotation: Subtype: Link Rect: 491, 497, 496, 501 Flags: Print AppearanceDictionary: true Destination: null Annotation: Subtype: Link Rect: 369, 23, 485, 30 Flags: Print AppearanceDictionary: true Annotation: Subtype: Link Rect: 547, 23, 551, 30 Flags: Print AppearanceDictionary: true Thumb: true Page: Label: 4 Annotations: Annotation: Subtype: Link Rect: 226, 726, 230, 733 Flags: Print AppearanceDictionary: true Destination: null Annotation: Subtype: Link Rect: 232, 726, 235, 733 Flags: Print AppearanceDictionary: true Destination: 58 Annotation: Subtype: Link Rect: 239, 726, 243, 733 Flags: Print AppearanceDictionary: true Destination: 58 Annotation: Subtype: Link Rect: 244, 726, 252, 733 Flags: Print AppearanceDictionary: true Destination: null Annotation: Subtype: Link Rect: 96, 670, 100, 679 Flags: Print AppearanceDictionary: true Destination: 1 Annotation: Subtype: Link Rect: 88, 610, 95, 618 Flags: Print AppearanceDictionary: true Destination: null Annotation: Subtype: Link Rect: 97, 610, 104, 618 Flags: Print AppearanceDictionary: true Destination: null Annotation: Subtype: Link Rect: 120, 565, 124, 575 Flags: Print AppearanceDictionary: true Destination: 9 Annotation: Subtype: Link Rect: 165, 565, 170, 575 Flags: Print AppearanceDictionary: true Destination: 9 Annotation: Subtype: Link Rect: 281, 523, 286, 533 Flags: Print AppearanceDictionary: true Destination: 9 Annotation: Subtype: Link Rect: 244, 408, 249, 418 Flags: Print AppearanceDictionary: true Destination: 9 Annotation: Subtype: Link Rect: 450, 639, 454, 648 Flags: Print AppearanceDictionary: true Destination: 1 Annotation: Subtype: Link Rect: 431, 618, 435, 627 Flags: Print AppearanceDictionary: true Destination: 34 Annotation: Subtype: Link Rect: 432, 565, 436, 575 Flags: Print AppearanceDictionary: true Destination: 21 Annotation: Subtype: Link Rect: 372, 503, 376, 512 Flags: Print AppearanceDictionary: true Destination: 34 Annotation: Subtype: Link Rect: 449, 150, 456, 158 Flags: Print AppearanceDictionary: true Destination: null Annotation: Subtype: Link Rect: 460, 150, 468, 158 Flags: Print AppearanceDictionary: true Destination: null Annotation: Subtype: Link Rect: 314, 140, 321, 147 Flags: Print AppearanceDictionary: true Destination: null Annotation: Subtype: Link Rect: 506, 108, 514, 116 Flags: Print AppearanceDictionary: true Destination: null Annotation: Subtype: Link Rect: 436, 23, 551, 30 Flags: Print AppearanceDictionary: true Thumb: true Page: Label: 5 Annotations: Annotation: Subtype: Link Rect: 168, 66, 175, 73 Flags: Print AppearanceDictionary: true Destination: null Annotation: Subtype: Link Rect: 369, 23, 485, 30 Flags: Print AppearanceDictionary: true Annotation: Subtype: Link Rect: 547, 23, 551, 30 Flags: Print AppearanceDictionary: true Thumb: true Page: Label: 6 Annotations: Annotation: Subtype: Link Rect: 215, 715, 222, 723 Flags: Print AppearanceDictionary: true Destination: null Annotation: Subtype: Link Rect: 105, 694, 112, 702 Flags: Print AppearanceDictionary: true Destination: null Annotation: Subtype: Link Rect: 104, 588, 112, 595 Flags: Print AppearanceDictionary: true Destination: null Annotation: Subtype: Link Rect: 231, 564, 236, 573 Flags: Print AppearanceDictionary: true Destination: 21 Annotation: Subtype: Link Rect: 110, 525, 117, 533 Flags: Print AppearanceDictionary: true Destination: null Annotation: Subtype: Link Rect: 247, 492, 255, 500 Flags: Print AppearanceDictionary: true Destination: null Annotation: Subtype: Link Rect: 107, 436, 111, 446 Flags: Print AppearanceDictionary: true Destination: 21 Annotation: Subtype: Link Rect: 256, 429, 263, 437 Flags: Print AppearanceDictionary: true Destination: null Annotation: Subtype: Link Rect: 140, 386, 148, 393 Flags: Print AppearanceDictionary: true Destination: null Annotation: Subtype: Link Rect: 156, 269, 164, 276 Flags: Print AppearanceDictionary: true Destination: null Annotation: Subtype: Link Rect: 205, 211, 209, 221 Flags: Print AppearanceDictionary: true Destination: 21 Annotation: Subtype: Link Rect: 129, 173, 136, 180 Flags: Print AppearanceDictionary: true Destination: null Annotation: Subtype: Link Rect: 380, 485, 387, 493 Flags: Print AppearanceDictionary: true Destination: null Annotation: Subtype: Link Rect: 414, 464, 421, 472 Flags: Print AppearanceDictionary: true Destination: null Annotation: Subtype: Link Rect: 424, 422, 431, 430 Flags: Print AppearanceDictionary: true Destination: null Annotation: Subtype: Link Rect: 452, 225, 456, 235 Flags: Print AppearanceDictionary: true Destination: 34 Annotation: Subtype: Link Rect: 436, 23, 551, 30 Flags: Print AppearanceDictionary: true Thumb: true Page: Label: 7 Annotations: Annotation: Subtype: Link Rect: 63, 283, 68, 292 Flags: Print AppearanceDictionary: true Destination: 34 Annotation: Subtype: Link Rect: 79, 276, 86, 283 Flags: Print AppearanceDictionary: true Destination: null Annotation: Subtype: Link Rect: 284, 252, 289, 261 Flags: Print AppearanceDictionary: true Destination: 9 Annotation: Subtype: Link Rect: 161, 171, 168, 179 Flags: Print AppearanceDictionary: true Destination: null Annotation: Subtype: Link Rect: 189, 53, 193, 62 Flags: Print AppearanceDictionary: true Destination: 34 Annotation: Subtype: Link Rect: 64, 391, 67, 399 Flags: Print AppearanceDictionary: true Destination: 1 Annotation: Subtype: Link Rect: 134, 394, 138, 400 Flags: Print AppearanceDictionary: true Destination: 58 Annotation: Subtype: Link Rect: 142, 394, 145, 400 Flags: Print AppearanceDictionary: true Destination: 58 Annotation: Subtype: Link Rect: 66, 373, 72, 379 Flags: Print AppearanceDictionary: true Destination: null Annotation: Subtype: Link Rect: 61, 363, 68, 369 Flags: Print AppearanceDictionary: true Destination: null Annotation: Subtype: Link Rect: 151, 363, 157, 369 Flags: Print AppearanceDictionary: true Destination: null Annotation: Subtype: Link Rect: 320, 152, 325, 159 Flags: Print AppearanceDictionary: true Destination: null Annotation: Subtype: Link Rect: 369, 23, 485, 30 Flags: Print AppearanceDictionary: true Annotation: Subtype: Link Rect: 547, 23, 551, 30 Flags: Print AppearanceDictionary: true Thumb: true Page: Label: 8 Annotations: Annotation: Subtype: Link Rect: 266, 631, 273, 639 Flags: Print AppearanceDictionary: true Destination: null Annotation: Subtype: Link Rect: 253, 429, 258, 439 Flags: Print AppearanceDictionary: true Destination: 34 Annotation: Subtype: Link Rect: 70, 349, 77, 357 Flags: Print AppearanceDictionary: true Destination: null Annotation: Subtype: Link Rect: 94, 297, 97, 304 Flags: Print AppearanceDictionary: true Destination: null Annotation: Subtype: Link Rect: 99, 297, 106, 304 Flags: Print AppearanceDictionary: true Destination: null Annotation: Subtype: Link Rect: 167, 265, 175, 273 Flags: Print AppearanceDictionary: true Destination: null Annotation: Subtype: Link Rect: 114, 203, 122, 210 Flags: Print AppearanceDictionary: true Destination: null Annotation: Subtype: Link Rect: 263, 203, 270, 210 Flags: Print AppearanceDictionary: true Destination: null Annotation: Subtype: Link Rect: 232, 192, 240, 200 Flags: Print AppearanceDictionary: true Destination: null Annotation: Subtype: Link Rect: 101, 161, 108, 168 Flags: Print AppearanceDictionary: true Destination: null Annotation: Subtype: Link Rect: 328, 335, 334, 341 Flags: Print AppearanceDictionary: true Destination: null Annotation: Subtype: Link Rect: 409, 242, 413, 250 Flags: Print AppearanceDictionary: true Destination: 1 Annotation: Subtype: Link Rect: 436, 23, 551, 30 Flags: Print AppearanceDictionary: true Thumb: true Page: Label: 9 Annotations: Annotation: Subtype: Link Rect: 134, 725, 139, 731 Flags: Print AppearanceDictionary: true Destination: null Annotation: Subtype: Link Rect: 157, 683, 163, 689 Flags: Print AppearanceDictionary: true Destination: null Annotation: Subtype: Link Rect: 173, 278, 179, 284 Flags: Print AppearanceDictionary: true Destination: null Annotation: Subtype: Link Rect: 92, 269, 98, 275 Flags: Print AppearanceDictionary: true Destination: null Annotation: Subtype: Link Rect: 99, 269, 105, 275 Flags: Print AppearanceDictionary: true Destination: null Annotation: Subtype: Link Rect: 158, 146, 163, 152 Flags: Print AppearanceDictionary: true Destination: null Annotation: Subtype: Link Rect: 326, 662, 332, 668 Flags: Print AppearanceDictionary: true Destination: null Annotation: Subtype: Link Rect: 333, 662, 339, 668 Flags: Print AppearanceDictionary: true Destination: null Annotation: Subtype: Link Rect: 475, 654, 481, 660 Flags: Print AppearanceDictionary: true Destination: null Annotation: Subtype: Link Rect: 441, 645, 447, 651 Flags: Print AppearanceDictionary: true Destination: null Annotation: Subtype: Link Rect: 533, 452, 538, 458 Flags: Print AppearanceDictionary: true Destination: null Annotation: Subtype: Link Rect: 409, 216, 415, 222 Flags: Print AppearanceDictionary: true Destination: null Annotation: Subtype: Link Rect: 543, 190, 549, 196 Flags: Print AppearanceDictionary: true Destination: null Annotation: Subtype: Link Rect: 433, 179, 551, 187 Flags: Print AppearanceDictionary: true Annotation: Subtype: Link Rect: 303, 171, 316, 178 Flags: Print AppearanceDictionary: true Annotation: Subtype: Link Rect: 370, 119, 376, 125 Flags: Print AppearanceDictionary: true Destination: null Annotation: Subtype: Link Rect: 446, 81, 452, 87 Flags: Print AppearanceDictionary: true Destination: null Annotation: Subtype: Link Rect: 388, 56, 394, 62 Flags: Print AppearanceDictionary: true Destination: null Annotation: Subtype: Link Rect: 369, 23, 485, 30 Flags: Print AppearanceDictionary: true Annotation: Subtype: Link Rect: 547, 23, 551, 30 Flags: Print AppearanceDictionary: true Thumb: true Page: Label: 10 Annotations: Annotation: Subtype: Link Rect: 285, 708, 291, 714 Flags: Print AppearanceDictionary: true Destination: null Annotation: Subtype: Link Rect: 83, 700, 89, 706 Flags: Print AppearanceDictionary: true Destination: null Annotation: Subtype: Link Rect: 170, 700, 175, 706 Flags: Print AppearanceDictionary: true Destination: null Annotation: Subtype: Link Rect: 85, 671, 90, 677 Flags: Print AppearanceDictionary: true Destination: null Annotation: Subtype: Link Rect: 149, 299, 155, 305 Flags: Print AppearanceDictionary: true Destination: null Annotation: Subtype: Link Rect: 436, 23, 551, 30 Flags: Print AppearanceDictionary: true Thumb: true Page: Label: 11 Annotations: Annotation: Subtype: Link Rect: 163, 296, 256, 303 Flags: Print AppearanceDictionary: true Annotation: Subtype: Link Rect: 463, 359, 551, 366 Flags: Print AppearanceDictionary: true Annotation: Subtype: Link Rect: 303, 350, 338, 357 Flags: Print AppearanceDictionary: true Annotation: Subtype: Link Rect: 457, 289, 546, 296 Flags: Print AppearanceDictionary: true Annotation: Subtype: Link Rect: 472, 153, 551, 160 Flags: Print AppearanceDictionary: true Annotation: Subtype: Link Rect: 303, 144, 346, 151 Flags: Print AppearanceDictionary: true Annotation: Subtype: Link Rect: 369, 23, 485, 30 Flags: Print AppearanceDictionary: true Annotation: Subtype: Link Rect: 543, 23, 551, 30 Flags: Print AppearanceDictionary: true Thumb: true Page: Label: 12 Annotations: Annotation: Subtype: Link Rect: 200, 714, 201, 725 Flags: Print AppearanceDictionary: true Annotation: Subtype: Link Rect: 200, 714, 201, 725 Flags: Print AppearanceDictionary: true Annotation: Subtype: Link Rect: 208, 714, 210, 725 Flags: Print AppearanceDictionary: true Annotation: Subtype: Link Rect: 198, 714, 210, 725 Flags: Print AppearanceDictionary: true Annotation: Subtype: Link Rect: 210, 714, 211, 725 Flags: Print AppearanceDictionary: true Annotation: Subtype: Link Rect: 105, 698, 106, 709 Flags: Print AppearanceDictionary: true Annotation: Subtype: Link Rect: 105, 698, 106, 709 Flags: Print AppearanceDictionary: true Annotation: Subtype: Link Rect: 112, 698, 115, 709 Flags: Print AppearanceDictionary: true Annotation: Subtype: Link Rect: 103, 698, 115, 709 Flags: Print AppearanceDictionary: true Annotation: Subtype: Link Rect: 115, 698, 116, 709 Flags: Print AppearanceDictionary: true Annotation: Subtype: Link Rect: 530, 698, 531, 709 Flags: Print AppearanceDictionary: true Annotation: Subtype: Link Rect: 530, 698, 531, 709 Flags: Print AppearanceDictionary: true Annotation: Subtype: Link Rect: 537, 698, 539, 709 Flags: Print AppearanceDictionary: true Annotation: Subtype: Link Rect: 527, 698, 539, 709 Flags: Print AppearanceDictionary: true Annotation: Subtype: Link Rect: 539, 698, 541, 709 Flags: Print AppearanceDictionary: true Annotation: Subtype: Link Rect: 115, 651, 116, 662 Flags: Print AppearanceDictionary: true Annotation: Subtype: Link Rect: 115, 651, 116, 662 Flags: Print AppearanceDictionary: true Annotation: Subtype: Link Rect: 122, 651, 124, 662 Flags: Print AppearanceDictionary: true Annotation: Subtype: Link Rect: 112, 651, 124, 662 Flags: Print AppearanceDictionary: true Annotation: Subtype: Link Rect: 124, 651, 126, 662 Flags: Print AppearanceDictionary: true Annotation: Subtype: Link Rect: 306, 635, 307, 646 Flags: Print AppearanceDictionary: true Annotation: Subtype: Link Rect: 306, 635, 307, 646 Flags: Print AppearanceDictionary: true Annotation: Subtype: Link Rect: 313, 635, 316, 646 Flags: Print AppearanceDictionary: true Annotation: Subtype: Link Rect: 303, 635, 316, 646 Flags: Print AppearanceDictionary: true Annotation: Subtype: Link Rect: 316, 635, 317, 646 Flags: Print AppearanceDictionary: true Annotation: Subtype: Link Rect: 410, 635, 411, 646 Flags: Print AppearanceDictionary: true Annotation: Subtype: Link Rect: 410, 635, 411, 646 Flags: Print AppearanceDictionary: true Annotation: Subtype: Link Rect: 418, 635, 420, 646 Flags: Print AppearanceDictionary: true Annotation: Subtype: Link Rect: 408, 635, 420, 646 Flags: Print AppearanceDictionary: true Annotation: Subtype: Link Rect: 420, 635, 421, 646 Flags: Print AppearanceDictionary: true Annotation: Subtype: Link Rect: 359, 619, 360, 630 Flags: Print AppearanceDictionary: true Annotation: Subtype: Link Rect: 359, 619, 360, 630 Flags: Print AppearanceDictionary: true Annotation: Subtype: Link Rect: 366, 619, 369, 630 Flags: Print AppearanceDictionary: true Annotation: Subtype: Link Rect: 356, 619, 369, 630 Flags: Print AppearanceDictionary: true Annotation: Subtype: Link Rect: 369, 619, 370, 630 Flags: Print AppearanceDictionary: true Annotation: Subtype: Link Rect: 436, 23, 551, 30 Flags: Print AppearanceDictionary: true Thumb: true Page: Label: 13 Annotations: Annotation: Subtype: Link Rect: 369, 23, 485, 30 Flags: Print AppearanceDictionary: true Annotation: Subtype: Link Rect: 543, 23, 551, 30 Flags: Print AppearanceDictionary: true Thumb: true Checksum: a346903b Type: CRC32 Checksum: 04870ed7ca198e69f6cc2c07a0713e3a Type: MD5 Checksum: fc8c56934ee195a5540569dd6ba2f358a9b1d711 Type: SHA-1