5b42c0487b43724fffd00a4284cb38d7 223957.pdf f8e91b80ecc73fa51c572dfa75e4158b06bfb78e 223957.pdf 2d234d331db4924914e2b0c626e102ecdf90e68fe5241efccc4605e47782ba1b 223957.pdf Title: Deciphering the Iron Side of Stroke: Neurodegeneration at the Crossroads Between Iron Dyshomeostasis, Excitotoxicity, and Ferroptosis Subject: In general, iron represents a double-edged sword in metabolism in most tissues, especially in the brain. Keywords: iron, reactive oxygen species, ferroptosis, stroke, excitotoxicity, iron dyshomeostasis, neurodegeneration, transferrin saturation Author: Octavi Martí-Sistac and Teresa Gasull Creator: LaTeX with hyperref package Producer: pdfTeX-1.40.15 CreationDate: Fri Feb 15 15:10:56 2019 CET ModDate: Fri Feb 15 15:23:23 2019 CET Tagged: no UserProperties: no Suspects: no Form: none JavaScript: no Pages: 17 Encrypted: no Page size: 595.276 x 779.528 pts Page rot: 0 File size: 2146800 bytes Optimized: no PDF version: 1.6 name type encoding emb sub uni object ID ------------------------------------ ----------------- ---------------- --- --- --- --------- AREUXA+MTSYN Type 1 Builtin yes yes no 38 0 TECUJH+MinionPro-Regular Type 1 Custom yes yes no 26 0 LBLBBO+HelveticaNeueLTStd-Bd Type 1 Custom yes yes no 27 0 NSKUOH+HelveticaNeueLTStd-Lt Type 1 Custom yes yes no 28 0 CCVXXJ+HelveticaNeueLTStd-BdIt Type 1 Custom yes yes no 33 0 BVZIAF+HelveticaNeueLTStd-LtIt Type 1 Custom yes yes no 34 0 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Title: Iron Uptake and Handling by Parenchymal Brain Cells Children: Item: Title: Receptors Involved in Iron Uptake by Brain Cells Item: Title: Mechanisms and Proteins Involved in Cytosolic Iron Handling in Different Brain Cell Types Item: Title: Iron Dyshomeostasis in the Brain Item: Title: Iron Overload Worsens Neurological Damage Both in Ischemic Stroke and Intracerebral Hemorrhage Children: Item: Title: Iron Overload Condition in Stroke Damage and Outcome Item: Title: Effect of Stroke on Brain Iron Item: Title: Brain Regulation of Iron Metabolism During Stroke Children: Item: Title: Endogenous Mechanisms Involved in the Protection of Brain Cells From Excess Iron Following AIS Item: Title: Endogenous Mechanisms Involved in the Protection of Brain Cells From Excess Iron Following ICH Item: Title: The Ferroptotic Component of Stroke-Induced Neurodegeneration Children: Item: Title: The Concept of Ferroptosis: Molecular Players Involved in Ferroptosis in the Neurons Item: Title: Glutamate-Induced Iron Uptake in Neurons and Ferroptosis Item: Title: Ferroptosis in AIS and ICH Stroke Subtypes: Effect of Ferroptosis Inhibitors and Iron Chelators Item: Title: Conclusion Item: Title: Author Contributions Item: Title: Funding Item: Title: References Filters: FilterPipeline: FlateDecode Fonts: Type1: Font: BaseFont: CCVXXJ+HelveticaNeueLTStd-BdIt FontSubset: true FirstChar: 42 LastChar: 121 FontDescriptor: FontName: CCVXXJ+HelveticaNeueLTStd-BdIt Flags: Symbolic FontBBox: -166, -218, 1129, 975 FontFile: true EncodingDictionary: Differences: true Font: BaseFont: PAARCL+RBLMI FontSubset: true FirstChar: 60 LastChar: 60 FontDescriptor: FontName: PAARCL+RBLMI Flags: Symbolic FontBBox: -11, -230, 987, 750 FontFile: true Font: BaseFont: BVZIAF+HelveticaNeueLTStd-LtIt FontSubset: true FirstChar: 39 LastChar: 242 FontDescriptor: FontName: BVZIAF+HelveticaNeueLTStd-LtIt Flags: Symbolic FontBBox: -165, -214, 1099, 951 FontFile: true EncodingDictionary: Differences: true Font: 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Differences: true XMP: iron, reactive oxygen species, ferroptosis, stroke, excitotoxicity, iron dyshomeostasis, neurodegeneration, transferrin saturation pdfTeX-1.40.15 1.5 application/pdf fnins-13-00085.tex Deciphering the Iron Side of Stroke: Neurodegeneration at the Crossroads Between Iron Dyshomeostasis, Excitotoxicity, and Ferroptosis In general, iron represents a double-edged sword in metabolism in most tissues, especially in the brain. Octavi Martí-Sistac and Teresa Gasull 2019-02-15T19:40:56+05:30 iron reactive oxygen species ferroptosis stroke excitotoxicity iron dyshomeostasis neurodegeneration transferrin saturation 2019-02-15T19:40:56+05:30 2019-02-15T19:53:23+05:30 2019-02-15T19:53:23+05:30 LaTeX with hyperref package uuid:f7fd18d7-a3ea-4882-a2b6-7f7590a3959b uuid:5496564e-5aa0-4481-af09-28157d2d1d58 Pages: Page: Sequence: 1 Annotations: Annotation: Subtype: Link Rect: 43, 718, 163, 754 Annotation: Subtype: Link Rect: 522, 736, 551, 745 Annotation: Subtype: Link Rect: 462, 727, 551, 737 Annotation: Subtype: Link Rect: 455, 718, 551, 729 Annotation: Subtype: Link Rect: 86, 462, 160, 472 Annotation: Subtype: Link Rect: 78, 67, 160, 74 Annotation: Subtype: Link Rect: 521, 677, 551, 707 Annotation: Subtype: Link Rect: 176, 565, 551, 678 Annotation: Subtype: Link Rect: 310, 545, 392, 557 Annotation: Subtype: Link Rect: 422, 545, 480, 557 Annotation: Subtype: Link Rect: 43, 29, 122, 38 Annotation: Subtype: Link Rect: 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Annotation: Subtype: Link Rect: 312, 157, 394, 167 Annotation: Subtype: Link Rect: 525, 129, 551, 138 Annotation: Subtype: Link Rect: 312, 120, 390, 129 Annotation: Subtype: Link Rect: 537, 91, 551, 101 Annotation: Subtype: Link Rect: 312, 83, 399, 91 Annotation: Subtype: Link Rect: 43, 29, 122, 38 Annotation: Subtype: Link Rect: 125, 29, 185, 38 Annotation: Subtype: Link Rect: 434, 29, 551, 38 Page: Sequence: 15 Annotations: Annotation: Subtype: Link Rect: 80, 688, 152, 697 Annotation: Subtype: Link Rect: 207, 659, 275, 668 Annotation: Subtype: Link Rect: 208, 640, 293, 649 Annotation: Subtype: Link Rect: 53, 632, 75, 639 Annotation: Subtype: Link Rect: 198, 602, 290, 612 Annotation: Subtype: Link Rect: 86, 574, 187, 583 Annotation: Subtype: Link Rect: 219, 546, 293, 555 Annotation: Subtype: Link Rect: 53, 538, 77, 545 Annotation: Subtype: Link Rect: 216, 508, 293, 517 Annotation: Subtype: Link Rect: 53, 500, 70, 507 Annotation: Subtype: Link Rect: 279, 479, 293, 489 Annotation: 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328 Annotation: Subtype: Link Rect: 108, 281, 211, 290 Annotation: Subtype: Link Rect: 53, 243, 148, 252 Annotation: Subtype: Link Rect: 185, 224, 269, 233 Annotation: Subtype: Link Rect: 218, 195, 293, 205 Annotation: Subtype: Link Rect: 53, 188, 77, 194 Annotation: Subtype: Link Rect: 82, 148, 179, 157 Annotation: Subtype: Link Rect: 195, 120, 267, 129 Annotation: Subtype: Link Rect: 208, 91, 293, 101 Annotation: Subtype: Link Rect: 53, 84, 91, 90 Annotation: Subtype: Link Rect: 396, 688, 499, 697 Annotation: Subtype: Link Rect: 462, 659, 549, 668 Annotation: Subtype: Link Rect: 328, 623, 423, 631 Annotation: Subtype: Link Rect: 537, 593, 551, 602 Annotation: Subtype: Link Rect: 312, 583, 442, 593 Annotation: Subtype: Link Rect: 372, 555, 473, 564 Annotation: Subtype: Link Rect: 510, 527, 551, 536 Annotation: Subtype: Link Rect: 312, 518, 342, 526 Annotation: Subtype: Link Rect: 373, 489, 444, 498 Annotation: Subtype: Link Rect: 537, 460, 551, 470 Annotation: Subtype: Link Rect: 312, 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Subtype: Link Rect: 43, 29, 122, 38 Annotation: Subtype: Link Rect: 125, 29, 185, 38 Annotation: Subtype: Link Rect: 434, 29, 551, 38 Checksum: 6765869a Type: CRC32 Checksum: 5b42c0487b43724fffd00a4284cb38d7 Type: MD5 Checksum: f8e91b80ecc73fa51c572dfa75e4158b06bfb78e Type: SHA-1