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Primary healthcare Effectiveness and cost-effectiveness of Improving clinicians’ diagnostic and communication Skills on Antibiotic prescribing Appropriateness in patients with acute Cough in primary care in CATalonia (the ISAAC-CAT study): study protocol for a cluster randomised controlled trial Rafa Ruiz Ana Moragas Marta Trapero-Bertran Antoni Sisó Anna Berenguera Glòria Oliva Alícia Borràs-Santos Ana García-Sangenís Jaume Puig-Junoy Josep M. 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