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cell-specific gene regulatory effects of genetic associations in multiple sclerosis Destination: edu.harvard.hul.ois.jhove.module.pdf.PdfSimpleObject@612fc6eb Children: Item: Title: Results Destination: edu.harvard.hul.ois.jhove.module.pdf.PdfSimpleObject@1060b431 Children: Item: Title: Predicted regulatory effects (PRE) of MS-associated variants Destination: edu.harvard.hul.ois.jhove.module.pdf.PdfSimpleObject@612679d6 Item: Title: Protein connectivity among products of MS-associated loci Destination: edu.harvard.hul.ois.jhove.module.pdf.PdfSimpleObject@11758f2a Item: Title: Individualized PRE correlate with gene expression Destination: edu.harvard.hul.ois.jhove.module.pdf.PdfSimpleObject@e720b71 Item: Title: Intra-individual risk networks are more connected in MS Destination: edu.harvard.hul.ois.jhove.module.pdf.PdfSimpleObject@1b26f7b2 Item: Title: Discussion Destination: edu.harvard.hul.ois.jhove.module.pdf.PdfSimpleObject@491cc5c9 Item: Title: Methods Destination: edu.harvard.hul.ois.jhove.module.pdf.PdfSimpleObject@74ad1f1f Children: Item: Title: Predicted regulatory effects (PRE) Destination: edu.harvard.hul.ois.jhove.module.pdf.PdfSimpleObject@6a1aab78 Item: Title: Protein interaction network-based pathway analysis (PINBPA) Destination: edu.harvard.hul.ois.jhove.module.pdf.PdfSimpleObject@462d5aee Item: Title: Cell-specific transcriptomes Destination: edu.harvard.hul.ois.jhove.module.pdf.PdfSimpleObject@69b0fd6f Item: Title: References Destination: edu.harvard.hul.ois.jhove.module.pdf.PdfSimpleObject@757942a1 Item: Title: References Destination: edu.harvard.hul.ois.jhove.module.pdf.PdfSimpleObject@4a87761d Item: Title: References Destination: edu.harvard.hul.ois.jhove.module.pdf.PdfSimpleObject@66d1af89 Item: Title: Acknowledgements Destination: edu.harvard.hul.ois.jhove.module.pdf.PdfSimpleObject@8646db9 Item: Title: Author contribution Destination: edu.harvard.hul.ois.jhove.module.pdf.PdfSimpleObject@37374a5e Item: Title: ACKNOWLEDGEMENTS 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JJCDJL+AdvOTe75a9404.I Flags: Nonsymbolic FontBBox: -83, -197, 1020, 906 FontFile3: true Encoding: WinAnsiEncoding Font: BaseFont: Helvetica2 FirstChar: 32 LastChar: 150 FontDescriptor: FontName: Helvetica2 Flags: Nonsymbolic FontBBox: -166, -225, 1000, 931 FontFile3: true Encoding: WinAnsiEncoding Font: BaseFont: Helvetica-Oblique FirstChar: 0 LastChar: 255 FontDescriptor: FontName: Helvetica-Oblique Flags: Nonsymbolic, Italic FontBBox: -170, -225, 1116, 931 FontFile3: true Encoding: WinAnsiEncoding Font: BaseFont: JJBBPC+AdvOTea1a7398 FontSubset: true FirstChar: 35 LastChar: 233 FontDescriptor: FontName: JJBBPC+AdvOTea1a7398 Flags: Nonsymbolic FontBBox: -31, -197, 979, 906 FontFile3: true Encoding: WinAnsiEncoding XMP: application/pdf doi:10.1038/s41467-019-09773-y A systems biology approach uncovers cell-specific gene regulatory effects of genetic associations in multiple sclerosis Lohith Madireddy Nikolaos A. Patsopoulos Chris Cotsapas Steffan D. Bos Ashley Beecham Jacob McCauley Kicheol Kim Xiaoming Jia Adam Santaniello Stacy J. Caillier Till F. M. Andlauer Lisa F. Barcellos Tone Berge Luisa Bernardinelli Filippo Martinelli-Boneschi David R. Booth Farren Briggs Elisabeth G. Celius Manuel Comabella Giancarlo Comi Bruce A. C. Cree Sandra D’Alfonso Katrina Dedham Pierre Duquette Efthimios Dardiotis Federica Esposito Bertrand Fontaine Christiane Gasperi An Goris Bénédicte Dubois Pierre-Antoine Gourraud Georgios Hadjigeorgiou Jonathan Haines Clive Hawkins Bernhard Hemmer Rogier Hintzen Dana Horakova Noriko Isobe Seema Kalra Jun-ichi Kira Michael Khalil Ingrid Kockum Christina M. Lill Matthew R. Lincoln Felix Luessi Roland Martin Annette Oturai Aarno Palotie Margaret A. Pericak-Vance Roland Henry Janna Saarela Adrian Ivinson Tomas Olsson Bruce V. Taylor Graeme J. Stewart Hanne F. Harbo Alastair Compston Stephen L. Hauser David A. Hafler Frauke Zipp Philip Jager Stephen Sawcer Jorge R. Oksenberg Sergio E. Baranzini Springer US Nature Communications, doi:10.1038/s41467-019-09773-y 10.1038/s41467-019-09773-y http://dx.doi.org/10.1038/s41467-019-09773-y journal Nature Communications © 2019, The Author(s) 2041-1723 10.1038/s41467-019-09773-y springer.com springerlink.com 2010-04-23 True 10.1038/s41467-019-09773-y springer.com springerlink.com Springer 2019-06-28T15:47:27+02:00 2019-06-15T10:05:24+05:30 2019-06-28T15:47:27+02:00 True iText® 5.3.5 ©2000-2012 1T3XT BVBA (AGPL-version) VoR uuid:bf30691d-cdf9-4863-8759-90737353e3c9 uuid:15b52657-4afd-40a9-93e1-697c86213823 default 1 converted uuid:b1c986c2-fad2-429b-a789-91c9b11a2055 converted to PDF/A-2b pdfToolbox 2019-06-15T10:06:19+05:30 2 B Sergio E. Baranzini http://orcid.org/0000-0003-0067-194X http://ns.adobe.com/pdf/1.3/ pdf Adobe PDF Schema internal A name object indicating whether the document has been modified to include trapping information Trapped Text http://ns.adobe.com/pdfx/1.3/ pdfx pdfx internal ID of PDF/X standard GTS_PDFXVersion Text internal Conformance level of PDF/X standard GTS_PDFXConformance Text internal Company creating the PDF Company Text internal Date when document was last modified SourceModified Text external Mirrors crossmark:CrosMarkDomains CrossMarkDomains Seq Text internal Mirrors crossmark:DOI doi Text http://ns.adobe.com/xap/1.0/mm/ xmpMM XMP Media Management Schema internal UUID based identifier for specific incarnation of a document InstanceID URI internal The common identifier for all versions and renditions of a document. 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