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CET Size: 2703093 Format: PDF Version: 1.7 Status: Well-Formed and valid SignatureMatches: PDF-hul MIMEtype: application/pdf Profile: Linearized PDF PDFMetadata: Objects: 597 FreeObjects: 1 IncrementalUpdates: 1 DocumentCatalog: PageLayout: SinglePage PageMode: UseOutlines Outlines: Item: Title: A precision medicine test predicts clinical response after idarubicin and cytarabine induction therapy in AML patients Destination: edu.harvard.hul.ois.jhove.module.pdf.PdfSimpleObject@eafc191 Children: Item: Title: Introduction Destination: edu.harvard.hul.ois.jhove.module.pdf.PdfSimpleObject@612fc6eb Item: Title: Patients and methods Destination: edu.harvard.hul.ois.jhove.module.pdf.PdfSimpleObject@1060b431 Children: Item: Title: Patients and study design Destination: edu.harvard.hul.ois.jhove.module.pdf.PdfSimpleObject@612679d6 Item: Title: Chemotherapy regimen, drugs and evaluation Destination: edu.harvard.hul.ois.jhove.module.pdf.PdfSimpleObject@11758f2a Item: Title: Vivia’s PharmaFlow PM test Destination: edu.harvard.hul.ois.jhove.module.pdf.PdfSimpleObject@e720b71 Children: Item: Title: Native environment whole bone marrow sample Destination: edu.harvard.hul.ois.jhove.module.pdf.PdfSimpleObject@1b26f7b2 Item: Title: Modeling of ex vivo activity of CYT, IDA, and their combination Destination: edu.harvard.hul.ois.jhove.module.pdf.PdfSimpleObject@491cc5c9 Item: Title: Probability of clinical outcome modeling clinical correlation Destination: edu.harvard.hul.ois.jhove.module.pdf.PdfSimpleObject@74ad1f1f Item: Title: Data collection and study endpoints Destination: edu.harvard.hul.ois.jhove.module.pdf.PdfSimpleObject@6a1aab78 Item: Title: Statistical analyses Destination: edu.harvard.hul.ois.jhove.module.pdf.PdfSimpleObject@462d5aee Item: Title: Results Destination: edu.harvard.hul.ois.jhove.module.pdf.PdfSimpleObject@69b0fd6f Children: Item: Title: Patient characteristics Destination: edu.harvard.hul.ois.jhove.module.pdf.PdfSimpleObject@757942a1 Item: Title: Ex vivo PharmaFlow test characterization of CYT-IDA combination Destination: edu.harvard.hul.ois.jhove.module.pdf.PdfSimpleObject@4a87761d Item: Title: Clinical responses among AML patients treated with CYT-IDA Destination: edu.harvard.hul.ois.jhove.module.pdf.PdfSimpleObject@66d1af89 Item: Title: Correlation between ex vivo activity and clinical response to CYT-IDA Destination: edu.harvard.hul.ois.jhove.module.pdf.PdfSimpleObject@8646db9 Item: Title: OS according to the ex vivo activity and observed clinical response Destination: edu.harvard.hul.ois.jhove.module.pdf.PdfSimpleObject@37374a5e Item: Title: Discussion Destination: edu.harvard.hul.ois.jhove.module.pdf.PdfSimpleObject@4671e53b Item: Title: Acknowledgements Destination: edu.harvard.hul.ois.jhove.module.pdf.PdfSimpleObject@2db7a79b Item: Title: Supplementary data Destination: edu.harvard.hul.ois.jhove.module.pdf.PdfSimpleObject@6950e31 Item: Title: References Destination: edu.harvard.hul.ois.jhove.module.pdf.PdfSimpleObject@b7dd107 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FontDescriptor: FontName: FCBHDG+AdvOT596495f2+03 Flags: Symbolic FontBBox: -677, -533, 832, 1008 FontFile3: true EncodingDictionary: Differences: true ToUnicode: true CIDFontType0: Font: BaseFont: QUNMAI+CharisSIL-Italic CIDSystemInfo: Registry: Adobe Registry: Identity Supplement: 0 FontDescriptor: FontName: QUNMAI+CharisSIL-Italic Flags: Serif, Symbolic, Italic FontBBox: -716, -533, 3058, 1270 FontFile3: true Font: BaseFont: GXPEQC+CharisSIL CIDSystemInfo: Registry: Adobe Registry: Identity Supplement: 0 FontDescriptor: FontName: GXPEQC+CharisSIL Flags: Serif, Symbolic FontBBox: -692, -533, 3000, 1270 FontFile3: true XMP: application/pdf doi:10.1016/j.leukres.2018.11.006 A precision medicine test predicts clinical response after idarubicin and cytarabine induction therapy in AML patients David Martínez-Cuadrón Cristina Gil Josefina Serrano Gabriela Rodríguez Jaime Pérez-Oteyza Raimundo García-Boyero Santiago Jiménez-Bravo Susana Vives María Belén Vidriales Esperanza Lavilla José A. Pérez-Simón Mar Tormo Mercedes Colorado Juan Bergua Juan A. López Pilar Herrera Pilar Hernández-Campo Julián Gorrochategui Daniel Primo Jose Luis Rojas Jesús Villoria Federico Moscardó Iñaki Troconiz María Linares Gómez Joaquín Martínez-López Joan Ballesteros Miguel Sanz Pau Montesinos on behalf of the Spanish PETHEMA group Acute myeloid leukemia Ex vivo assay Pharmacological profile Complete remission Clinical correlation Elsevier Leukemia Research, 76 (2018) 1-10. doi:10.1016/j.leukres.2018.11.006 journal Leukemia Research © 2018 The Authors. 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