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Billingsley Creator: Springer Producer: iText® 5.3.5 ©2000-2012 1T3XT BVBA (AGPL-version) CreationDate: Thu May 16 09:04:22 2019 CEST ModDate: Thu May 16 13:58:19 2019 CEST Tagged: no UserProperties: no Suspects: no Form: AcroForm JavaScript: no Pages: 9 Encrypted: no Page size: 595.276 x 790.866 pts Page rot: 0 File size: 1250470 bytes Optimized: no PDF version: 1.4 name type encoding emb sub uni object ID ------------------------------------ ----------------- ---------------- --- --- --- --------- JLCMGD+AdvOT46dcae81+fb Type 1C Custom yes yes yes 21 0 JLCMGC+AdvOT46dcae81+20 Type 1C WinAnsi yes yes no 22 0 JLCMGB+AdvOT46dcae81 Type 1C WinAnsi yes yes no 23 0 JLCCOF+AdvTT5afe5d37.B Type 1C WinAnsi yes yes no 479 0 Arial-BoldMT Type 1C WinAnsi yes no no 480 0 JLCMGE+AdvOT65f8a23b.I Type 1C WinAnsi yes yes no 24 0 JLCEJN+AdvOTa20b42a7 Type 1C WinAnsi yes yes no 481 0 JLCMGF+AdvOT65f8a23b.I+20 Type 1C WinAnsi yes yes no 265 0 JLCEJO+AdvOTa20b42a7+20 Type 1C WinAnsi yes yes no 482 0 JLCEJP+AdvTT6780a46b Type 1C WinAnsi yes yes no 25 0 JLCFOI+AdvTT6780a46b+20 Type 1C WinAnsi yes yes no 26 0 JLCMKG+AdvMyriad_R Type 1C WinAnsi yes yes no 27 0 JLCMGG+AdvOT3b30f6db.B Type 1C WinAnsi yes yes no 29 0 JLCMHH+AdvOT46dcae81+03 Type 1C Custom yes yes yes 267 0 JLCOGN+AdvTTab7e17fd Type 1C WinAnsi yes yes no 28 0 JLCPLI+AdvTT6780a46b+fb Type 1C Custom yes yes yes 30 0 JLDABG+AdvOT7d2ebc01 Type 1C WinAnsi yes yes no 31 0 JLCOHN+AdvTTab7e17fd+22 Type 1C Custom yes yes no 32 0 JLCPKH+AdvOT919a0533.B Type 1C WinAnsi yes yes no 33 0 JLDHKJ+AdvOT3b30f6db.B+20 Type 1C WinAnsi yes yes no 264 0 JLDHNJ+AdvOT8608a8d1+02 Type 1C Custom yes yes yes 266 0 Jhove (Rel. 1.22.1, 2019-04-17) Date: 2021-01-31 02:20:54 CET RepresentationInformation: 224135.pdf ReportingModule: PDF-hul, Rel. 1.12.1 (2019-04-17) LastModified: 2020-11-11 16:27:26 CET Size: 1250470 Format: PDF Version: 1.4 Status: Well-Formed, but not valid SignatureMatches: PDF-hul ID: PDF-HUL-122 ErrorMessage: edu.harvard.hul.ois.jhove.module.pdf.PdfInvalidException: Invalid indirect destination - 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referenced object 'bm_CR56' cannot be found Offset: 917611 MIMEtype: application/pdf PDFMetadata: Objects: 563 FreeObjects: 1 IncrementalUpdates: 0 DocumentCatalog: PageLayout: SinglePage PageMode: UseOutlines Language: EN Outlines: Item: Title: Mitochondria function associated genes contribute to Parkinson’s Disease risk and later age at onset Destination: edu.harvard.hul.ois.jhove.module.pdf.PdfSimpleObject@11758f2a Children: Item: Title: Introduction Destination: edu.harvard.hul.ois.jhove.module.pdf.PdfSimpleObject@e720b71 Item: Title: Results Destination: edu.harvard.hul.ois.jhove.module.pdf.PdfSimpleObject@1b26f7b2 Children: Item: Title: Common variation within mitochondria function genes contributes to the heritable component of PD Destination: edu.harvard.hul.ois.jhove.module.pdf.PdfSimpleObject@491cc5c9 Item: Title: Mitochondria function-specific polygenic risk score is significantly associated with disease status Destination: edu.harvard.hul.ois.jhove.module.pdf.PdfSimpleObject@74ad1f1f Item: Title: Mitochondria function-specific polygenic risk score is significantly associated with later age at onset Destination: edu.harvard.hul.ois.jhove.module.pdf.PdfSimpleObject@6a1aab78 Item: Title: Mendelian randomization suggests potential causal association of 14 novel mitochondria function genes with PD risk Destination: edu.harvard.hul.ois.jhove.module.pdf.PdfSimpleObject@462d5aee Item: Title: Exploring the expression of the novel mitochondria risk genes provides additional support for their role in PD Destination: edu.harvard.hul.ois.jhove.module.pdf.PdfSimpleObject@69b0fd6f Item: Title: Discussion Destination: edu.harvard.hul.ois.jhove.module.pdf.PdfSimpleObject@757942a1 Item: Title: Methods Destination: edu.harvard.hul.ois.jhove.module.pdf.PdfSimpleObject@4a87761d Children: Item: Title: Samples and quality control of IPDGC datasets Destination: edu.harvard.hul.ois.jhove.module.pdf.PdfSimpleObject@66d1af89 Item: Title: Curation of genes implicated in mitochondrial disorders and associated with mitochondrial function Destination: edu.harvard.hul.ois.jhove.module.pdf.PdfSimpleObject@8646db9 Item: Title: Cohort-level heritability estimates and meta-analysis Destination: edu.harvard.hul.ois.jhove.module.pdf.PdfSimpleObject@37374a5e Item: Title: Risk profiles versus disease status and age at onset Destination: edu.harvard.hul.ois.jhove.module.pdf.PdfSimpleObject@4671e53b Item: Title: Mendelian randomization to explore possible causal effect of mitochondria function genes Destination: edu.harvard.hul.ois.jhove.module.pdf.PdfSimpleObject@2db7a79b Item: Title: Co-expression network analysis Destination: edu.harvard.hul.ois.jhove.module.pdf.PdfSimpleObject@6950e31 Item: Title: Expression-weighted cell-type enrichment (EWCE): evaluating enrichment of mitochondrial genes associated with PD risk Destination: edu.harvard.hul.ois.jhove.module.pdf.PdfSimpleObject@b7dd107 Item: Title: OMIM data Destination: edu.harvard.hul.ois.jhove.module.pdf.PdfSimpleObject@42eca56e Item: Title: Supplementary information Destination: edu.harvard.hul.ois.jhove.module.pdf.PdfSimpleObject@52f759d7 Item: Title: Acknowledgements Destination: edu.harvard.hul.ois.jhove.module.pdf.PdfSimpleObject@7cbd213e Item: Title: Author contributions Destination: edu.harvard.hul.ois.jhove.module.pdf.PdfSimpleObject@192d3247 Item: Title: Competing interests Destination: edu.harvard.hul.ois.jhove.module.pdf.PdfSimpleObject@3ecd23d9 Item: Title: ACKNOWLEDGMENTS Destination: edu.harvard.hul.ois.jhove.module.pdf.PdfSimpleObject@569cfc36 Item: Title: A9 Destination: edu.harvard.hul.ois.jhove.module.pdf.PdfSimpleObject@43bd930a Info: Title: Mitochondria function associated genes contribute to Parkinson’s Disease risk and later age at onset Author: Kimberley J. 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FontDescriptor: FontName: JLCPLI+AdvTT6780a46b+fb Flags: Symbolic FontBBox: 9, 0, 875, 750 FontFile3: true EncodingDictionary: Differences: true ToUnicode: true Font: BaseFont: JLCCOF+AdvTT5afe5d37.B FontSubset: true FirstChar: 65 LastChar: 84 FontDescriptor: FontName: JLCCOF+AdvTT5afe5d37.B Flags: Nonsymbolic FontBBox: -31, -250, 895, 864 FontFile3: true Encoding: WinAnsiEncoding Font: BaseFont: JLDABG+AdvOT7d2ebc01 FontSubset: true FirstChar: 50 LastChar: 57 FontDescriptor: FontName: JLDABG+AdvOT7d2ebc01 Flags: Nonsymbolic FontBBox: -31, -208, 958, 916 FontFile3: true Encoding: WinAnsiEncoding XMP: application/pdf doi:10.1038/s41531-019-0080-x Mitochondria function associated genes contribute to Parkinson’s Disease risk and later age at onset Kimberley J. Billingsley Ines A. Barbosa Sara Bandrés-Ciga John P. Quinn Vivien J. Bubb Charu Deshpande Juan A. Botia Regina H. Reynolds David Zhang Michael A. Simpson Cornelis Blauwendraat Ziv Gan-Or J. Raphael Gibbs Mike A. Nalls Andrew Singleton A. Noyce A. Tucci B. Middlehurst D. Kia M. Tan H. Houlden H. R. Morris H. Plun-Favreau P. Holmans J. Hardy D. Trabzuni J. Bras K. Mok K. Kinghorn N. Wood P. Lewis R. Guerreiro R. Lovering L. R’Bibo M. Rizig V. Escott-Price V. Chelban T. Foltynie N. Williams A. Brice F. Danjou S. Lesage M. Martinez A. Giri C. Schulte K. Brockmann J. Simón-Sánchez P. Heutink P. Rizzu M. Sharma T. Gasser A. Nicolas M. Cookson F. Faghri D. Hernandez J. Shulman L. Robak S. Lubbe S. Finkbeiner N. Mencacci C. Lungu S. Scholz X. Reed H. Leonard G. Rouleau L. Krohan J. van Hilten J. Marinus A. Adarmes-Gómez M. Aguilar I. Alvarez V. Alvarez F. Javier Barrero J. Bergareche Yarza I. Bernal-Bernal M. Blazquez M. Bonilla-Toribio Bernal M. Boungiorno Dolores Buiza-Rueda A. Cámara M. Carcel F. Carrillo M. Carrión-Claro D. Cerdan J. Clarimón Y. Compta M. Diez-Fairen O. Dols-Icardo J. Duarte R. l. Duran F. Escamilla-Sevilla M. Ezquerra M. Fernández R. Fernández-Santiago C. Garcia P. García-Ruiz P. Gómez-Garre M. Gomez Heredia I. Gonzalez-Aramburu A. Gorostidi Pagola J. Hoenicka J. Infante S. Jesús A. Jimenez-Escrig J. Kulisevsky M. Labrador-Espinosa J. Lopez-Sendon A. López de Munain Arregui D. Macias I. Martínez Torres J. Marín M. Jose Marti J. Martínez-Castrillo C. Méndez-del-Barrio M. Menéndez González A. Mínguez P. Mir E. Mondragon Rezola E. Muñoz J. Pagonabarraga P. Pastor F. Perez Errazquin T. Periñán-Tocino J. Ruiz-Martínez C. Ruz A. Sanchez Rodriguez M. Sierra E. Suarez-Sanmartin C. Tabernero J. Pablo Tartari C. Tejera-Parrado E. Tolosa F. Valldeoriola L. Vargas-González L. Vela F. Vives A. Zimprich L. Pihlstrom P. Taba K. Majamaa A. Siitonen N. Okubadejo O. Ojo Mina Ryten Sulev Koks Springer US npj Parkinson’s Disease, doi:10.1038/s41531-019-0080-x 10.1038/s41531-019-0080-x http://dx.doi.org/10.1038/s41531-019-0080-x journal npj Parkinson’s Disease © 2019, The Author(s) 2373-8057 10.1038/s41531-019-0080-x springer.com springerlink.com 2010-04-23 True 10.1038/s41531-019-0080-x springer.com springerlink.com Springer 2019-05-16T13:58:19+02:00 2019-05-16T12:34:22+05:30 2019-05-16T13:58:19+02:00 True iText® 5.3.5 ©2000-2012 1T3XT BVBA (AGPL-version) VoR uuid:7f61d9a5-3cd8-4ac5-a7c9-2df6580d479d uuid:e6a6bfbe-00fc-4879-a84e-8c1dde31f0f3 default 1 converted uuid:42ab09dc-674b-4bb9-9fec-305358a70c46 converted to PDF/A-2b pdfToolbox 2019-05-16T12:35:12+05:30 2 B Regina H. Reynolds http://orcid.org/0000-0001-6470-7919 Sulev Koks http://orcid.org/0000-0001-6087-6643 http://ns.adobe.com/pdf/1.3/ pdf Adobe PDF Schema internal A name object indicating whether the document has been modified to include trapping information Trapped Text http://ns.adobe.com/pdfx/1.3/ pdfx pdfx internal ID of PDF/X standard GTS_PDFXVersion Text internal Conformance level of PDF/X standard GTS_PDFXConformance Text internal Company creating the PDF Company Text internal Date when document was last modified SourceModified Text external Mirrors crossmark:CrosMarkDomains CrossMarkDomains Seq Text internal Mirrors crossmark:DOI doi Text http://ns.adobe.com/xap/1.0/mm/ xmpMM XMP Media Management Schema internal UUID based identifier for specific incarnation of a document InstanceID URI internal The common identifier for all versions and renditions of a document. 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