9dc49719722a609215bf88116a14e060  224168.pdf
e40e8fa774c0c6d0ae60b9228fdea438af4a42c1  224168.pdf
b0a6958d085e6b9ceae9e1f3c04f54c62c7d0bf7a59b04cc566f6980d3d67ec2  224168.pdf

Title:          Sex differences in the 1H NMR metabolic profile of serum in cardiovascular risk patients
Subject:        Scientific Reports, doi:10.1038/s41598-019-38881-4
Keywords:       
Author:         Ignasi Barba
Creator:        Springer
Producer:       iText® 5.3.5 ©2000-2012 1T3XT BVBA (AGPL-version)
CreationDate:   Fri Feb  8 11:27:24 2019 CET
ModDate:        Thu Feb 14 12:18:08 2019 CET
Tagged:         no
UserProperties: no
Suspects:       no
Form:           AcroForm
JavaScript:     no
Pages:          7
Encrypted:      no
Page size:      595.276 x 782.362 pts
Page rot:       0
File size:      1355479 bytes
Optimized:      no
PDF version:    1.4


name                                 type              encoding         emb sub uni object ID
------------------------------------ ----------------- ---------------- --- --- --- ---------
QBZIDH+Corbel-Bold                   CID TrueType      Identity-H       yes yes yes     59  0
KFGKXT+TimesNewRomanPSMT             Type 1C           WinAnsi          yes yes yes   1885  0
MinionPro-Regular                    Type 1C           Custom           yes no  yes     61  0
SVWQNP+Corbel-Bold2                  Type 1C           WinAnsi          yes yes yes     62  0
NUCNWH+Corbel2                       Type 1C           WinAnsi          yes yes yes     64  0
QYFNDH+Corbel                        CID TrueType      Identity-H       yes yes yes     65  0
MyriadPro-It                         Type 1C           WinAnsi          yes no  yes     66  0
NUCNWH+Corbel2                       Type 1C           WinAnsi          yes yes yes   1817  0
MinionPro-Bold                       Type 1C           WinAnsi          yes no  yes     60  0
EuclidSymbol                         Type 1C           Custom           yes no  yes     63  0
MinionPro-It                         Type 1C           Custom           yes no  yes   1799  0


Jhove (Rel. 1.22.1, 2019-04-17)
 Date: 2022-02-11 02:31:21 CET
 RepresentationInformation: 224168.pdf
  ReportingModule: PDF-hul, Rel. 1.12.1 (2019-04-17)
  LastModified: 2022-02-10 09:18:21 CET
  Size: 1355479
  Format: PDF
  Version: 1.4
  Status: Well-Formed, but not valid
  SignatureMatches:
   PDF-hul
  ID: PDF-HUL-122
  ErrorMessage: edu.harvard.hul.ois.jhove.module.pdf.PdfInvalidException: Invalid indirect destination - referenced object 'SpringerNature_SciRep_38881.indd:
Table 1. Epidemiological and clinical data of the patients included in the study. Data are expressed as average standard deviation or number of cases (%) and obtained from the blood test date closer to the stress test.:39' cannot be found
   Offset: 977337
  ID: PDF-HUL-122
  ErrorMessage: edu.harvard.hul.ois.jhove.module.pdf.PdfInvalidException: Invalid indirect destination - referenced object 'SpringerNature_SciRep_38881.indd:Figure 1. Typical spectra from serum samples. (A) Pulse-and-acquire spectra (B) CPMG with an effective T2 delay of 32⁜琀洀猀 ＀䏾＀ 䐀椀昀昀甀猀椀漀渀 攀搀椀琀攀搀 猀瀀攀挀琀爀愀 愀渀搀 ＀䓾＀ 一伀䔀匀夀倀刀㄀䐀 猀瀀攀挀琀爀愀 漀戀琀愀椀渀攀搀 昀爀漀洀 愀 搀攀瀀爀漀琀攀椀渀椀稀攀搀 猀攀爀甀洀 猀愀洀瀀氀攀⻾￾￾￾￾￾￾＀㨀㐀ㄩ⽂潲摥牛〠〠そ⽓畢瑹灥⽌楮欯䉓㰼⽗‰⽔祰支䉯牤敲⽓⽓㸾⽒散瑛㔲㤮㈹㤠ㄹ〮㜶㌠㔳㌮㘱㤠ㄷ㠮㘲㉝⽈⽎⽁值㰯丠㐵‰⁒㸾㸾੥湤潢樊㈴‰扪਼㰯䘠㐯呹灥⽁湮潴⽄敳琨SpringerNature_SciRep_38881.indd:Figure 1. Typical spectra from serum samples. (A) Pulse-and-acquire spectra (B) CPMG with an effective T2 delay of 32⁜琀洀猀 ＀䏾＀ 䐀椀昀昀甀猀椀漀渀 攀搀椀琀攀搀 猀瀀攀挀琀爀愀 愀渀搀 ＀䓾＀ 一伀䔀匀夀倀刀㄀䐀 猀瀀攀挀琀爀愀 漀戀琀愀椀渀攀搀 昀爀漀洀 愀 搀攀瀀爀漀琀攀椀渀椀稀攀搀 猀攀爀甀洀 猀愀洀瀀氀攀⻾￾￾￾￾￾￾＀㨀㐀㈩⽂潲摥牛〠〠そ⽓畢瑹灥⽌楮欯䉓㰼⽗‰⽔祰支䉯牤敲⽓⽓㸾⽒散瑛㌰㌮㠲ㄠㄸ〮㜶㌠㌰㠮ㄱ㔠ㄶ㠮㘲㉝⽈⽎⽁值㰯丠㐶‰⁒㸾㸾੥湤潢樊㈵‰扪਼㰯䘠㐯呹灥⽁湮潴⽄敳琨SpringerNature_SciRep_38881.indd:	17.	Gowda, N. G. A., Raferty, D., Gowda, N. G. A. & Raftery, D. Quantitating Metabolites in Protein Precipitated Serum Using NMR Spectroscopy. Anal. Chem. 86, 5433–5440 (2014).
:43' cannot be found
   Offset: 977337
  ID: PDF-HUL-122
  ErrorMessage: edu.harvard.hul.ois.jhove.module.pdf.PdfInvalidException: Invalid indirect destination - referenced object 'SpringerNature_SciRep_38881.indd:Figure 1. Typical spectra from serum samples. (A) Pulse-and-acquire spectra (B) CPMG with an effective T2 delay of 32⁜琀洀猀 ＀䏾＀ 䐀椀昀昀甀猀椀漀渀 攀搀椀琀攀搀 猀瀀攀挀琀爀愀 愀渀搀 ＀䓾＀ 一伀䔀匀夀倀刀㄀䐀 猀瀀攀挀琀爀愀 漀戀琀愀椀渀攀搀 昀爀漀洀 愀 搀攀瀀爀漀琀攀椀渀椀稀攀搀 猀攀爀甀洀 猀愀洀瀀氀攀⻾￾￾￾￾￾￾＀㨀㐀㈩⽂潲摥牛〠〠そ⽓畢瑹灥⽌楮欯䉓㰼⽗‰⽔祰支䉯牤敲⽓⽓㸾⽒散瑛㌰㌮㠲ㄠㄸ〮㜶㌠㌰㠮ㄱ㔠ㄶ㠮㘲㉝⽈⽎⽁值㰯丠㐶‰⁒㸾㸾੥湤潢樊㈵‰扪਼㰯䘠㐯呹灥⽁湮潴⽄敳琨SpringerNature_SciRep_38881.indd:	17.	Gowda, N. G. A., Raferty, D., Gowda, N. G. A. & Raftery, D. Quantitating Metabolites in Protein Precipitated Serum Using NMR Spectroscopy. Anal. Chem. 86, 5433–5440 (2014).
:43' cannot be found
   Offset: 977337
  ID: PDF-HUL-122
  ErrorMessage: edu.harvard.hul.ois.jhove.module.pdf.PdfInvalidException: Invalid indirect destination - referenced object 'SpringerNature_SciRep_38881.indd:Figure 2. Pattern recognition results from the CPMG spectra (A) corresponds to the score plot of the OPLS-DA model, each point corresponds to a sample; green female, blue male. (B) Permutation analysis showing the validity of the model and (:44' cannot be found
   Offset: 977337
  ID: PDF-HUL-122
  ErrorMessage: edu.harvard.hul.ois.jhove.module.pdf.PdfInvalidException: Invalid indirect destination - referenced object 'SpringerNature_SciRep_38881.indd:Figure 2. Pattern recognition results from the CPMG spectra (A) corresponds to the score plot of the OPLS-DA model, each point corresponds to a sample; green female, blue male. (B) Permutation analysis showing the validity of the model and :45' cannot be found
   Offset: 977337
  ID: PDF-HUL-122
  ErrorMessage: edu.harvard.hul.ois.jhove.module.pdf.PdfInvalidException: Invalid indirect destination - referenced object 'SpringerNature_SciRep_38881.indd:Figure 2. Pattern recognition results from the CPMG spectra (A) corresponds to the score plot of the OPLS-DA model, each point corresponds to a sample; green female, blue male. (B) Permutation analysis showing the validity of the model and:46' cannot be found
   Offset: 977337
  ID: PDF-HUL-122
  ErrorMessage: edu.harvard.hul.ois.jhove.module.pdf.PdfInvalidException: Invalid indirect destination - referenced object 'SpringerNature_SciRep_38881.indd:Figure 2. Pattern recognition results from the CPMG spectra (A) corresponds to the score plot of the OPLS-DA model, each point corresponds to a sample; green female, blue male. (B) Permutation analysis showing the validity of the model an:47' cannot be found
   Offset: 977337
  ID: PDF-HUL-122
  ErrorMessage: edu.harvard.hul.ois.jhove.module.pdf.PdfInvalidException: Invalid indirect destination - referenced object 'SpringerNature_SciRep_38881.indd:Figure 3. Results of the analysis performed on deproteinized samples. (A) First and second components of the Principal component analysis (B) OPLS-DA model obtained with the spectra from the deproteinized samples. (C) S-plot with the most :48' cannot be found
   Offset: 977337
  ID: PDF-HUL-122
  ErrorMessage: edu.harvard.hul.ois.jhove.module.pdf.PdfInvalidException: Invalid indirect destination - referenced object 'SpringerNature_SciRep_38881.indd:Figure 3. Results of the analysis performed on deproteinized samples. (A) First and second components of the Principal component analysis (B) OPLS-DA model obtained with the spectra from the deproteinized samples. (C) S-plot with the most:49' cannot be found
   Offset: 977337
  ID: PDF-HUL-122
  ErrorMessage: edu.harvard.hul.ois.jhove.module.pdf.PdfInvalidException: Invalid indirect destination - referenced object 'SpringerNature_SciRep_38881.indd:Figure 3. Results of the analysis performed on deproteinized samples. (A) First and second components of the Principal component analysis (B) OPLS-DA model obtained with the spectra from the deproteinized samples. (C) S-plot with the mos:50' cannot be found
   Offset: 977337
  ID: PDF-HUL-122
  ErrorMessage: edu.harvard.hul.ois.jhove.module.pdf.PdfInvalidException: Invalid indirect destination - referenced object 'SpringerNature_SciRep_38881.indd:
Table 2. Metabolite concentration derived from deproteinized spectra. Data in mmol/L.:51' cannot be found
   Offset: 977337
  ID: PDF-HUL-122
  ErrorMessage: edu.harvard.hul.ois.jhove.module.pdf.PdfInvalidException: Invalid indirect destination - referenced object 'SpringerNature_SciRep_38881.indd:
Table 2. Metabolite concentration derived from deproteinized spectra. Data in mmol/L.:52' cannot be found
   Offset: 977337
  MIMEtype: application/pdf
  PDFMetadata: 
   Objects: 1957
   FreeObjects: 1
   IncrementalUpdates: 0
   DocumentCatalog: 
    ViewerPreferences: 
     HideToolbar: false
     HideMenubar: false
     HideWindowUI: false
     FitWindow: false
     CenterWindow: false
     DisplayDocTitle: false
     NonFullScreenPageMode: UseNone
     Direction: L2R
     ViewArea: CropBox
     ViewClip: CropBox
     PrintArea: CropBox
     PageClip: CropBox
    PageLayout: SinglePage
    PageMode: UseOutlines
    Language: EN
    Outlines: 
     Item: 
      Title: Sex differences in the 1H NMR metabolic profile of serum in cardiovascular risk patients
      Children: 
       Item: 
        Title: Results
        Children: 
         Item: 
          Title: Patients. 
         Item: 
          Title: Spectra. 
         Item: 
          Title: Pattern Recognition. 
       Item: 
        Title: Discussion
        Children: 
         Item: 
          Title: Study limitations. 
       Item: 
        Title: Methods
        Children: 
         Item: 
          Title: Patients. 
         Item: 
          Title: Samples. 
         Item: 
          Title: Serum deproteinization. 
         Item: 
          Title: NMR spectroscopy. 
         Item: 
          Title: Data analysis. 
       Item: 
        Title: Acknowledgements
       Item: 
        Title: Figure 1 Typical spectra from serum samples.
       Item: 
        Title: Figure 2 Pattern recognition results from the CPMG spectra (A) corresponds to the score plot of the OPLS-DA model, each point corresponds to a sample green female, blue male.
       Item: 
        Title: Figure 3 Results of the analysis performed on deproteinized samples.
       Item: 
        Title: Table 1 Epidemiological and clinical data of the patients included in the study.
       Item: 
        Title: Table 2 Metabolite concentration derived from deproteinized spectra.
   Info: 
    Title: Sex differences in the 1H NMR metabolic profile of serum in cardiovascular risk patients
    Author: Ignasi Barba
    Subject: Scientific Reports, doi:10.1038/s41598-019-38881-4
    Keywords: 
    Creator: Springer
    Producer: iText® 5.3.5 ©2000-2012 1T3XT BVBA (AGPL-version)
    CreationDate: Fri Feb 08 11:57:24 CET 2019
    ModDate: Thu Feb 14 12:18:08 CET 2019
   ID: 0xb97b674b47fc266ec90fe5f8d2d03998, 0x25a2ab1468c377d8f05e7ccc71405428
   Filters: 
    FilterPipeline: FlateDecode
   Images: 
    Image: 
     NisoImageMetadata: 
      FormatName: image/png
      ImageWidth: 1100
      ImageHeight: 90
      ColorSpace: black is zero
      BitsPerSample: 1
      BitsPerSampleUnit: integer
     Filter: FlateDecode
     Intent: RelativeColorimetric
     Name: X
    Image: 
     NisoImageMetadata: 
      FormatName: image/png
      ImageWidth: 1000
      ImageHeight: 1092
      ColorSpace: black is zero
      BitsPerSample: 8
      BitsPerSampleUnit: integer
     Filter: FlateDecode
     Intent: RelativeColorimetric
     Name: X
   Fonts: 
    Type0: 
     Font: 
      BaseFont: QYFNDH+Corbel
      Encoding: Identity-H
      ToUnicode: true
     Font: 
      BaseFont: QBZIDH+Corbel-Bold
      Encoding: Identity-H
      ToUnicode: true
    Type1: 
     Font: 
      BaseFont: NUCNWH+Corbel2
      FontSubset: true
      FirstChar: 0
      LastChar: 255
      FontDescriptor: 
       FontName: NUCNWH+Corbel2
       Flags: Nonsymbolic
       FontBBox: -553, -239, 1110, 952
       FontFile3: true
      Encoding: WinAnsiEncoding
      ToUnicode: true
     Font: 
      BaseFont: MyriadPro-It
      FirstChar: 0
      LastChar: 255
      FontDescriptor: 
       FontName: MyriadPro-It
       Flags: Nonsymbolic, Italic
       FontBBox: -185, -250, 1090, 953
       FontFile3: true
      Encoding: WinAnsiEncoding
      ToUnicode: true
     Font: 
      BaseFont: MinionPro-It
      FirstChar: 0
      LastChar: 255
      FontDescriptor: 
       FontName: MinionPro-It
       Flags: Serif, Nonsymbolic, Italic
       FontBBox: -201, -360, 1684, 1002
       FontFile3: true
      EncodingDictionary: 
       BaseEncoding: WinAnsiEncoding
       Differences: true
      ToUnicode: true
     Font: 
      BaseFont: MinionPro-Bold
      FirstChar: 0
      LastChar: 255
      FontDescriptor: 
       FontName: MinionPro-Bold
       Flags: Serif, Nonsymbolic
       FontBBox: -319, -360, 1684, 1024
       FontFile3: true
      Encoding: WinAnsiEncoding
      ToUnicode: true
     Font: 
      BaseFont: KFGKXT+TimesNewRomanPSMT
      FontSubset: true
      FirstChar: 32
      LastChar: 121
      FontDescriptor: 
       FontName: KFGKXT+TimesNewRomanPSMT
       Flags: Serif, Nonsymbolic
       FontBBox: -568, -307, 2000, 1007
       FontFile3: true
      Encoding: WinAnsiEncoding
      ToUnicode: true
     Font: 
      BaseFont: MinionPro-Regular
      FirstChar: 0
      LastChar: 255
      FontDescriptor: 
       FontName: MinionPro-Regular
       Flags: Serif, Nonsymbolic
       FontBBox: -290, -360, 1684, 989
       FontFile3: true
      EncodingDictionary: 
       BaseEncoding: WinAnsiEncoding
       Differences: true
      ToUnicode: true
     Font: 
      BaseFont: SVWQNP+Corbel-Bold2
      FontSubset: true
      FirstChar: 0
      LastChar: 255
      FontDescriptor: 
       FontName: SVWQNP+Corbel-Bold2
       Flags: Nonsymbolic
       FontBBox: -556, -239, 1155, 952
       FontFile3: true
      Encoding: WinAnsiEncoding
      ToUnicode: true
     Font: 
      BaseFont: EuclidSymbol
      FirstChar: 0
      LastChar: 255
      FontDescriptor: 
       FontName: EuclidSymbol
       Flags: Symbolic
       FontBBox: -166, -253, 1090, 950
       FontFile3: true
      EncodingDictionary: 
       BaseEncoding: WinAnsiEncoding
       Differences: true
      ToUnicode: true
    CIDFontType2: 
     Font: 
      BaseFont: QYFNDH+Corbel
      CIDSystemInfo: 
       Registry: Adobe
       Registry: Identity
       Supplement: 0
      FontDescriptor: 
       FontName: QYFNDH+Corbel
       Flags: Symbolic
       FontBBox: -553, -239, 1110, 952
       FontFile2: true
     Font: 
      BaseFont: QBZIDH+Corbel-Bold
      CIDSystemInfo: 
       Registry: Adobe
       Registry: Identity
       Supplement: 0
      FontDescriptor: 
       FontName: QBZIDH+Corbel-Bold
       Flags: Symbolic
       FontBBox: -556, -239, 1155, 952
       FontFile2: true
   XMP: <x:xmpmeta x:xmptk="Adobe XMP Core 5.2-c001 63.143651, 2012/04/05-09:01:49        " xmlns:x="adobe:ns:meta/">
   <rdf:RDF xmlns:rdf="http://www.w3.org/1999/02/22-rdf-syntax-ns#">
      <rdf:Description rdf:about="" xmlns:dc="http://purl.org/dc/elements/1.1/">
         <dc:format>application/pdf</dc:format>
         <dc:identifier>doi:10.1038/s41598-019-38881-4</dc:identifier>
         <dc:publisher>
            <rdf:Bag>
               <rdf:li>Springer US</rdf:li>
            </rdf:Bag>
         </dc:publisher>
         <dc:description>
            <rdf:Alt>
               <rdf:li xml:lang="x-default">Scientific Reports, doi:10.1038/s41598-019-38881-4</rdf:li>
            </rdf:Alt>
         </dc:description>
         <dc:title>
            <rdf:Alt>
               <rdf:li xml:lang="x-default">Sex differences in the 1H NMR metabolic profile of serum in cardiovascular risk patients</rdf:li>
            </rdf:Alt>
         </dc:title>
         <dc:creator>
            <rdf:Seq>
               <rdf:li>Ignasi Barba</rdf:li>
               <rdf:li>Mireia Andramp#x000E9;s</rdf:li>
               <rdf:li>Irene Picamp#x000F3;n</rdf:li>
               <rdf:li>Santiago Aguade-Bruix</rdf:li>
               <rdf:li>David Garcia-Dorado</rdf:li>
            </rdf:Seq>
         </dc:creator>
      </rdf:Description>
      <rdf:Description rdf:about="" xmlns:prism="http://prismstandard.org/namespaces/basic/2.0/">
         <prism:doi>10.1038/s41598-019-38881-4</prism:doi>
         <prism:url>http://dx.doi.org/10.1038/s41598-019-38881-4</prism:url>
         <prism:aggregationType>journal</prism:aggregationType>
         <prism:publicationName>Scientific Reports</prism:publicationName>
         <prism:copyright>© 2019, The Author(s)</prism:copyright>
         <prism:issn>2045-2322</prism:issn>
      </rdf:Description>
      <rdf:Description rdf:about="" xmlns:pdfx="http://ns.adobe.com/pdfx/1.3/">
         <pdfx:doi>10.1038/s41598-019-38881-4</pdfx:doi>
      </rdf:Description>
      <rdf:Description rdf:about="" xmlns:xmp="http://ns.adobe.com/xap/1.0/">
         <xmp:CreatorTool>Springer</xmp:CreatorTool>
         <xmp:ModifyDate>2019-02-14T12:18:08+01:00</xmp:ModifyDate>
         <xmp:CreateDate>2019-02-08T15:57:24+05:30</xmp:CreateDate>
         <xmp:MetadataDate>2019-02-14T12:18:08+01:00</xmp:MetadataDate>
      </rdf:Description>
      <rdf:Description rdf:about="" xmlns:xmpRights="http://ns.adobe.com/xap/1.0/rights/">
         <xmpRights:Marked>True</xmpRights:Marked>
      </rdf:Description>
      <rdf:Description rdf:about="" xmlns:pdf="http://ns.adobe.com/pdf/1.3/">
         <pdf:Keywords></pdf:Keywords>
      <pdf:Producer>iText® 5.3.5 ©2000-2012 1T3XT BVBA (AGPL-version)</pdf:Producer></rdf:Description>
      <rdf:Description rdf:about="" xmlns:jav="http://www.niso.org/schemas/jav/1.0/">
         <jav:journal_article_version>VoR</jav:journal_article_version>
      </rdf:Description>
      <rdf:Description rdf:about="" xmlns:stEvt="http://ns.adobe.com/xap/1.0/sType/ResourceEvent#" xmlns:xmpMM="http://ns.adobe.com/xap/1.0/mm/">
         <xmpMM:DocumentID>uuid:a29bfdf8-5a43-4832-bd7e-cc5867f8ade5</xmpMM:DocumentID>
         <xmpMM:InstanceID>uuid:83287d11-439a-4a8e-851b-b4f2bc6fa631</xmpMM:InstanceID>
         <xmpMM:RenditionClass>default</xmpMM:RenditionClass>
         <xmpMM:VersionID>1</xmpMM:VersionID>
         <xmpMM:History>
            <rdf:Seq>
               <rdf:li rdf:parseType="Resource">
                  <stEvt:action>converted</stEvt:action>
                  <stEvt:instanceID>uuid:59a15053-69e2-4fd0-9bdb-59b1ead3c77e</stEvt:instanceID>
                  <stEvt:parameters>converted to PDF/A-2b</stEvt:parameters>
                  <stEvt:softwareAgent>pdfToolbox</stEvt:softwareAgent>
                  <stEvt:when>2019-02-08T15:58:07+05:30</stEvt:when>
               </rdf:li>
            </rdf:Seq>
         </xmpMM:History>
      </rdf:Description>
      <rdf:Description rdf:about="" xmlns:pdfaid="http://www.aiim.org/pdfa/ns/id/">
         <pdfaid:part>2</pdfaid:part>
         <pdfaid:conformance>B</pdfaid:conformance>
      </rdf:Description>
      <rdf:Description rdf:about="" xmlns:pdfaExtension="http://www.aiim.org/pdfa/ns/extension/" xmlns:pdfaProperty="http://www.aiim.org/pdfa/ns/property#" xmlns:pdfaSchema="http://www.aiim.org/pdfa/ns/schema#">
         <pdfaExtension:schemas>
            <rdf:Bag>
               <rdf:li rdf:parseType="Resource">
                  <pdfaSchema:namespaceURI>http://ns.adobe.com/xap/1.0/mm/</pdfaSchema:namespaceURI>
                  <pdfaSchema:prefix>xmpMM</pdfaSchema:prefix>
                  <pdfaSchema:schema>XMP Media Management Schema</pdfaSchema:schema>
                  <pdfaSchema:property>
                     <rdf:Seq>
                        <rdf:li rdf:parseType="Resource">
                           <pdfaProperty:category>internal</pdfaProperty:category>
                           <pdfaProperty:description>UUID based identifier for specific incarnation of a document</pdfaProperty:description>
                           <pdfaProperty:name>InstanceID</pdfaProperty:name>
                           <pdfaProperty:valueType>URI</pdfaProperty:valueType>
                        </rdf:li>
                        <rdf:li rdf:parseType="Resource">
                           <pdfaProperty:category>internal</pdfaProperty:category>
                           <pdfaProperty:description>The common identifier for all versions and renditions of a document.</pdfaProperty:description>
                           <pdfaProperty:name>OriginalDocumentID</pdfaProperty:name>
                           <pdfaProperty:valueType>URI</pdfaProperty:valueType>
                        </rdf:li>
                     </rdf:Seq>
                  </pdfaSchema:property>
               </rdf:li>
               <rdf:li rdf:parseType="Resource">
                  <pdfaSchema:namespaceURI>http://ns.adobe.com/pdf/1.3/</pdfaSchema:namespaceURI>
                  <pdfaSchema:prefix>pdf</pdfaSchema:prefix>
                  <pdfaSchema:schema>Adobe PDF Schema</pdfaSchema:schema>
                  <pdfaSchema:property>
                     <rdf:Seq>
                        <rdf:li rdf:parseType="Resource">
                           <pdfaProperty:category>internal</pdfaProperty:category>
                           <pdfaProperty:description>A name object indicating whether the document has been modified to include trapping information</pdfaProperty:description>
                           <pdfaProperty:name>Trapped</pdfaProperty:name>
                           <pdfaProperty:valueType>Text</pdfaProperty:valueType>
                        </rdf:li>
                     </rdf:Seq>
                  </pdfaSchema:property>
               </rdf:li>
               <rdf:li rdf:parseType="Resource">
                  <pdfaSchema:namespaceURI>http://ns.adobe.com/pdfx/1.3/</pdfaSchema:namespaceURI>
                  <pdfaSchema:prefix>pdfx</pdfaSchema:prefix>
                  <pdfaSchema:schema>pdfx</pdfaSchema:schema>
                  <pdfaSchema:property>
                     <rdf:Seq>
                        <rdf:li rdf:parseType="Resource">
                           <pdfaProperty:category>internal</pdfaProperty:category>
                           <pdfaProperty:description>ID of PDF/X standard</pdfaProperty:description>
                           <pdfaProperty:name>GTS_PDFXVersion</pdfaProperty:name>
                           <pdfaProperty:valueType>Text</pdfaProperty:valueType>
                        </rdf:li>
                        <rdf:li rdf:parseType="Resource">
                           <pdfaProperty:category>internal</pdfaProperty:category>
                           <pdfaProperty:description>Conformance level of PDF/X standard</pdfaProperty:description>
                           <pdfaProperty:name>GTS_PDFXConformance</pdfaProperty:name>
                           <pdfaProperty:valueType>Text</pdfaProperty:valueType>
                        </rdf:li>
                        <rdf:li rdf:parseType="Resource">
                           <pdfaProperty:category>internal</pdfaProperty:category>
                           <pdfaProperty:description>Company creating the PDF</pdfaProperty:description>
                           <pdfaProperty:name>Company</pdfaProperty:name>
                           <pdfaProperty:valueType>Text</pdfaProperty:valueType>
                        </rdf:li>
                        <rdf:li rdf:parseType="Resource">
                           <pdfaProperty:category>internal</pdfaProperty:category>
                           <pdfaProperty:description>Date when document was last modified</pdfaProperty:description>
                           <pdfaProperty:name>SourceModified</pdfaProperty:name>
                           <pdfaProperty:valueType>Text</pdfaProperty:valueType>
                        </rdf:li>
                        <rdf:li rdf:parseType="Resource">
                           <pdfaProperty:category>internal</pdfaProperty:category>
                           <pdfaProperty:description>Mirrors crossmark:DOI</pdfaProperty:description>
                           <pdfaProperty:name>doi</pdfaProperty:name>
                           <pdfaProperty:valueType>Text</pdfaProperty:valueType>
                        </rdf:li>
                     </rdf:Seq>
                  </pdfaSchema:property>
               </rdf:li>
               <rdf:li rdf:parseType="Resource">
                  <pdfaSchema:namespaceURI>http://www.aiim.org/pdfa/ns/id/</pdfaSchema:namespaceURI>
                  <pdfaSchema:prefix>pdfaid</pdfaSchema:prefix>
                  <pdfaSchema:schema>PDF/A ID Schema</pdfaSchema:schema>
                  <pdfaSchema:property>
                     <rdf:Seq>
                        <rdf:li rdf:parseType="Resource">
                           <pdfaProperty:category>internal</pdfaProperty:category>
                           <pdfaProperty:description>Part of PDF/A standard</pdfaProperty:description>
                           <pdfaProperty:name>part</pdfaProperty:name>
                           <pdfaProperty:valueType>Integer</pdfaProperty:valueType>
                        </rdf:li>
                        <rdf:li rdf:parseType="Resource">
                           <pdfaProperty:category>internal</pdfaProperty:category>
                           <pdfaProperty:description>Amendment of PDF/A standard</pdfaProperty:description>
                           <pdfaProperty:name>amd</pdfaProperty:name>
                           <pdfaProperty:valueType>Text</pdfaProperty:valueType>
                        </rdf:li>
                        <rdf:li rdf:parseType="Resource">
                           <pdfaProperty:category>internal</pdfaProperty:category>
                           <pdfaProperty:description>Conformance level of PDF/A standard</pdfaProperty:description>
                           <pdfaProperty:name>conformance</pdfaProperty:name>
                           <pdfaProperty:valueType>Text</pdfaProperty:valueType>
                        </rdf:li>
                     </rdf:Seq>
                  </pdfaSchema:property>
               </rdf:li>
               <rdf:li rdf:parseType="Resource">
                  <pdfaSchema:namespaceURI>http://prismstandard.org/namespaces/basic/2.0/</pdfaSchema:namespaceURI>
                  <pdfaSchema:prefix>prism</pdfaSchema:prefix>
                  <pdfaSchema:schema>Prism</pdfaSchema:schema>
                  <pdfaSchema:property>
                     <rdf:Seq>
                        <rdf:li rdf:parseType="Resource">
                           <pdfaProperty:category>external</pdfaProperty:category>
                           <pdfaProperty:description>The aggregation type specifies the unit of aggregation for a content collection. 
Comment 
PRISM recommends that the PRISM Aggregation Type Controlled Vocabulary be used to provide values for this element. 
Note: PRISM recommends against the use of the #other value currently allowed in this controlled vocabulary. In lieu of using #other please reach out to the PRISM group at info@prismstandard.org to request addition of your term to the Aggregation Type Controlled Vocabulary. 

</pdfaProperty:description>
                           <pdfaProperty:name>aggregationType</pdfaProperty:name>
                           <pdfaProperty:valueType>Text</pdfaProperty:valueType>
                        </rdf:li>
                        <rdf:li rdf:parseType="Resource">
                           <pdfaProperty:category>external</pdfaProperty:category>
                           <pdfaProperty:description>Copyright </pdfaProperty:description>
                           <pdfaProperty:name>copyright</pdfaProperty:name>
                           <pdfaProperty:valueType>Text</pdfaProperty:valueType>
                        </rdf:li>
                        <rdf:li rdf:parseType="Resource">
                           <pdfaProperty:category>external</pdfaProperty:category>
                           <pdfaProperty:description>The Digital Object Identifier for the article.
The DOI may also be used as the dc:identifier. If used as a dc:identifier, the URI form should be captured, and the bare identifier should also be captured using prism:doi. If an alternate unique identifier is used as the required dc:identifier, then the DOI should be specified as a bare identifier within prism:doi only. 
If the URL associated with a DOI is to be specified, then prism:url may be used in conjunction with prism:doi in order to provide the service endpoint (i.e. the URL). 
</pdfaProperty:description>
                           <pdfaProperty:name>doi</pdfaProperty:name>
                           <pdfaProperty:valueType>Text</pdfaProperty:valueType>
                        </rdf:li>
                        <rdf:li rdf:parseType="Resource">
                           <pdfaProperty:category>external</pdfaProperty:category>
                           <pdfaProperty:description>ISSN for an electronic version of the issue in which the resource occurs. 
Permits publishers to include a second ISSN, identifying an electronic version of the issue in which the resource occurs (therefore e(lectronic)Issn. If used, prism:eIssn MUST contain the ISSN of the electronic version. See prism:issn. 
</pdfaProperty:description>
                           <pdfaProperty:name>issn</pdfaProperty:name>
                           <pdfaProperty:valueType>Text</pdfaProperty:valueType>
                        </rdf:li>
                        <rdf:li rdf:parseType="Resource">
                           <pdfaProperty:category>external</pdfaProperty:category>
                           <pdfaProperty:description>Title of the magazine, or other publication, in which a resource was/will be published. 
Typically this will be used to provide the name of the magazine an article appeared in as metadata for the article, along with information such as the article title, the publisher, volume, number, and cover date. 

Note: Publication name can be used to differentiate between a print magazine and the online version if the names are different such as “magazine” and “magazine.com.” 
</pdfaProperty:description>
                           <pdfaProperty:name>publicationName</pdfaProperty:name>
                           <pdfaProperty:valueType>Text</pdfaProperty:valueType>
                        </rdf:li>
                        <rdf:li rdf:parseType="Resource">
                           <pdfaProperty:category>external</pdfaProperty:category>
                           <pdfaProperty:description>This element provides the url for an article or unit of content. 
The attribute platform is optionally allowed for situations in which multiple URLs must be specified. PRISM recommends that a subset of the PCV platform values, namely “mobile” and “web”, be used in conjunction with this element. 
NOTE: PRISM recommends against the use of the #other value allowed in the PRISM Platform controlled vocabulary. In lieu of using #other please reach out to the PRISM group at prism-wg@yahoogroups.com to request addition of your term to the Platform Controlled Vocabulary. 
</pdfaProperty:description>
                           <pdfaProperty:name>url</pdfaProperty:name>
                           <pdfaProperty:valueType>Text</pdfaProperty:valueType>
                        </rdf:li>
                     </rdf:Seq>
                  </pdfaSchema:property>
               </rdf:li>
               <rdf:li rdf:parseType="Resource">
                  <pdfaSchema:namespaceURI>http://www.niso.org/schemas/jav/1.0/</pdfaSchema:namespaceURI>
                  <pdfaSchema:prefix>jav</pdfaSchema:prefix>
                  <pdfaSchema:schema>NISO</pdfaSchema:schema>
                  <pdfaSchema:property>
                     <rdf:Seq>
                        <rdf:li rdf:parseType="Resource">
                           <pdfaProperty:category>external</pdfaProperty:category>
                           <pdfaProperty:description>Values for Journal Article Version are one of the following:
AO = Author’s Original
SMUR = Submitted Manuscript Under Review
AM = Accepted Manuscript
P = Proof
VoR = Version of Record
CVoR = Corrected Version of Record
EVoR = Enhanced Version of Record</pdfaProperty:description>
                           <pdfaProperty:name>journal_article_version</pdfaProperty:name>
                           <pdfaProperty:valueType>Closed Choice of Text</pdfaProperty:valueType>
                        </rdf:li>
                     </rdf:Seq>
                  </pdfaSchema:property>
               </rdf:li>
            </rdf:Bag>
         </pdfaExtension:schemas>
      </rdf:Description>
   </rdf:RDF>
</x:xmpmeta>
   Pages: 
    Page: 
     Sequence: 1
     Annotations: 
      Annotation: 
       Subtype: Link
       Rect: 222, 25, 369, 16
       Flags: Print
       AppearanceDictionary: true
      Annotation: 
       Subtype: Link
       Rect: 397, 343, 554, 331
       Flags: Print
       AppearanceDictionary: true
      Annotation: 
       Subtype: Link
       Rect: 155, 333, 189, 321
       Flags: Print
       AppearanceDictionary: true
      Annotation: 
       Subtype: Link
       Rect: 420, 323, 423, 311
       Flags: Print
       AppearanceDictionary: true
       Destination: 1782
      Annotation: 
       Subtype: Link
       Rect: 185, 313, 188, 301
       Flags: Print
       AppearanceDictionary: true
       Destination: 1782
      Annotation: 
       Subtype: Link
       Rect: 189, 313, 192, 301
       Flags: Print
       AppearanceDictionary: true
       Destination: 1782
      Annotation: 
       Subtype: Link
       Rect: 415, 303, 418, 291
       Flags: Print
       AppearanceDictionary: true
       Destination: 1782
      Annotation: 
       Subtype: Link
       Rect: 170, 153, 173, 141
       Flags: Print
       AppearanceDictionary: true
       Destination: 1782
      Annotation: 
       Subtype: Link
       Rect: 276, 133, 279, 121
       Flags: Print
       AppearanceDictionary: true
       Destination: 1782
      Annotation: 
       Subtype: Link
       Rect: 240, 53, 319, 43
       Flags: Print
       AppearanceDictionary: true
     Thumb: true
    Page: 
     Sequence: 2
     Annotations: 
      Annotation: 
       Subtype: Link
       Rect: 222, 25, 369, 16
       Flags: Print
       AppearanceDictionary: true
      Annotation: 
       Subtype: Link
       Rect: 219, 454, 222, 442
       Flags: Print
       AppearanceDictionary: true
       Destination: 1782
      Annotation: 
       Subtype: Link
       Rect: 192, 444, 195, 432
       Flags: Print
       AppearanceDictionary: true
       Destination: 1782
      Annotation: 
       Subtype: Link
       Rect: 310, 424, 313, 412
       Flags: Print
       AppearanceDictionary: true
       Destination: 1782
      Annotation: 
       Subtype: Link
       Rect: 542, 424, 544, 412
       Flags: Print
       AppearanceDictionary: true
       Destination: 1782
      Annotation: 
       Subtype: Link
       Rect: 169, 394, 175, 382
       Flags: Print
       AppearanceDictionary: true
       Destination: 1782
      Annotation: 
       Subtype: Link
       Rect: 395, 394, 400, 382
       Flags: Print
       AppearanceDictionary: true
       Destination: 1782
      Annotation: 
       Subtype: Link
       Rect: 539, 394, 545, 382
       Flags: Print
       AppearanceDictionary: true
       Destination: 1782
      Annotation: 
       Subtype: Link
       Rect: 546, 394, 552, 382
       Flags: Print
       AppearanceDictionary: true
       Destination: 1782
      Annotation: 
       Subtype: Link
       Rect: 542, 384, 545, 372
       Flags: Print
       AppearanceDictionary: true
       Destination: 1782
      Annotation: 
       Subtype: Link
       Rect: 546, 384, 552, 372
       Flags: Print
       AppearanceDictionary: true
       Destination: 1782
      Annotation: 
       Subtype: Link
       Rect: 359, 364, 364, 352
       Flags: Print
       AppearanceDictionary: true
       Destination: 1782
      Annotation: 
       Subtype: Link
       Rect: 226, 283, 230, 270
       Flags: Print
       AppearanceDictionary: true
       Destination: null
      Annotation: 
       Subtype: Link
       Rect: 170, 210, 176, 198
       Flags: Print
       AppearanceDictionary: true
       Destination: 1800
      Annotation: 
       Subtype: Link
       Rect: 461, 180, 467, 168
       Flags: Print
       AppearanceDictionary: true
       Destination: null
      Annotation: 
       Subtype: Link
       Rect: 461, 180, 467, 168
       Flags: Print
       AppearanceDictionary: true
       Destination: null
      Annotation: 
       Subtype: Link
       Rect: 461, 180, 467, 168
       Flags: Print
       AppearanceDictionary: true
       Destination: 1800
      Annotation: 
       Subtype: Link
       Rect: 343, 118, 354, 106
       Flags: Print
       AppearanceDictionary: true
       Destination: null
      Annotation: 
       Subtype: Link
       Rect: 539, 108, 549, 96
       Flags: Print
       AppearanceDictionary: true
       Destination: null
      Annotation: 
       Subtype: Link
       Rect: 227, 68, 237, 56
       Flags: Print
       AppearanceDictionary: true
       Destination: null
      Annotation: 
       Subtype: Link
       Rect: 215, 58, 225, 46
       Flags: Print
       AppearanceDictionary: true
       Destination: null
     Thumb: true
    Page: 
     Sequence: 3
     Annotations: 
      Annotation: 
       Subtype: Link
       Rect: 222, 25, 369, 16
       Flags: Print
       AppearanceDictionary: true
     Thumb: true
    Page: 
     Sequence: 4
     Annotations: 
      Annotation: 
       Subtype: Link
       Rect: 222, 25, 369, 16
       Flags: Print
       AppearanceDictionary: true
      Annotation: 
       Subtype: Link
       Rect: 485, 359, 496, 347
       Flags: Print
       AppearanceDictionary: true
       Destination: null
      Annotation: 
       Subtype: Link
       Rect: 418, 339, 428, 327
       Flags: Print
       AppearanceDictionary: true
       Destination: null
      Annotation: 
       Subtype: Link
       Rect: 174, 319, 184, 307
       Flags: Print
       AppearanceDictionary: true
       Destination: null
      Annotation: 
       Subtype: Link
       Rect: 209, 259, 213, 247
       Flags: Print
       AppearanceDictionary: true
       Destination: null
      Annotation: 
       Subtype: Link
       Rect: 350, 249, 354, 237
       Flags: Print
       AppearanceDictionary: true
       Destination: null
      Annotation: 
       Subtype: Link
       Rect: 385, 239, 390, 227
       Flags: Print
       AppearanceDictionary: true
       Destination: 1800
      Annotation: 
       Subtype: Link
       Rect: 395, 239, 519, 227
       Flags: Print
       AppearanceDictionary: true
      Annotation: 
       Subtype: Link
       Rect: 392, 177, 398, 165
       Flags: Print
       AppearanceDictionary: true
       Destination: 1800
      Annotation: 
       Subtype: Link
       Rect: 259, 167, 261, 155
       Flags: Print
       AppearanceDictionary: true
       Destination: 1782
      Annotation: 
       Subtype: Link
       Rect: 314, 157, 320, 145
       Flags: Print
       AppearanceDictionary: true
       Destination: 1800
      Annotation: 
       Subtype: Link
       Rect: 253, 137, 259, 125
       Flags: Print
       AppearanceDictionary: true
       Destination: 1800
      Annotation: 
       Subtype: Link
       Rect: 442, 127, 445, 115
       Flags: Print
       AppearanceDictionary: true
       Destination: 1782
      Annotation: 
       Subtype: Link
       Rect: 333, 97, 336, 85
       Flags: Print
       AppearanceDictionary: true
       Destination: 1782
     Thumb: true
    Page: 
     Sequence: 5
     Annotations: 
      Annotation: 
       Subtype: Link
       Rect: 222, 25, 369, 16
       Flags: Print
       AppearanceDictionary: true
      Annotation: 
       Subtype: Link
       Rect: 305, 431, 310, 419
       Flags: Print
       AppearanceDictionary: true
       Destination: 1800
      Annotation: 
       Subtype: Link
       Rect: 264, 421, 269, 409
       Flags: Print
       AppearanceDictionary: true
       Destination: 1800
      Annotation: 
       Subtype: Link
       Rect: 508, 411, 513, 399
       Flags: Print
       AppearanceDictionary: true
       Destination: 1800
      Annotation: 
       Subtype: Link
       Rect: 549, 411, 554, 399
       Flags: Print
       AppearanceDictionary: true
       Destination: 1800
      Annotation: 
       Subtype: Link
       Rect: 511, 401, 516, 389
       Flags: Print
       AppearanceDictionary: true
       Destination: 1800
      Annotation: 
       Subtype: Link
       Rect: 531, 371, 537, 359
       Flags: Print
       AppearanceDictionary: true
       Destination: 1800
      Annotation: 
       Subtype: Link
       Rect: 538, 371, 544, 359
       Flags: Print
       AppearanceDictionary: true
       Destination: 1800
      Annotation: 
       Subtype: Link
       Rect: 547, 371, 552, 359
       Flags: Print
       AppearanceDictionary: true
       Destination: 1800
      Annotation: 
       Subtype: Link
       Rect: 266, 319, 271, 307
       Flags: Print
       AppearanceDictionary: true
       Destination: 1800
      Annotation: 
       Subtype: Link
       Rect: 312, 319, 318, 307
       Flags: Print
       AppearanceDictionary: true
       Destination: 1800
      Annotation: 
       Subtype: Link
       Rect: 329, 279, 335, 267
       Flags: Print
       AppearanceDictionary: true
       Destination: 1800
     Thumb: true
    Page: 
     Sequence: 6
     Annotations: 
      Annotation: 
       Subtype: Link
       Rect: 222, 25, 369, 16
       Flags: Print
       AppearanceDictionary: true
      Annotation: 
       Subtype: Link
       Rect: 463, 697, 469, 684
       Flags: Print
       AppearanceDictionary: true
       Destination: 1800
      Annotation: 
       Subtype: Link
       Rect: 493, 520, 498, 508
       Flags: Print
       AppearanceDictionary: true
       Destination: 1800
      Annotation: 
       Subtype: Link
       Rect: 500, 520, 505, 508
       Flags: Print
       AppearanceDictionary: true
       Destination: 1800
      Annotation: 
       Subtype: Link
       Rect: 546, 400, 552, 388
       Flags: Print
       AppearanceDictionary: true
       Destination: 1800
      Annotation: 
       Subtype: Link
       Rect: 303, 380, 309, 368
       Flags: Print
       AppearanceDictionary: true
       Destination: 1800
     Thumb: true
    Page: 
     Sequence: 7
     Annotations: 
      Annotation: 
       Subtype: Link
       Rect: 222, 25, 369, 16
       Flags: Print
       AppearanceDictionary: true
      Annotation: 
       Subtype: Link
       Rect: 344, 280, 504, 268
       Flags: Print
       AppearanceDictionary: true
     Thumb: true
  Checksum: 18fb0cb7
   Type: CRC32
  Checksum: 9dc49719722a609215bf88116a14e060
   Type: MD5
  Checksum: e40e8fa774c0c6d0ae60b9228fdea438af4a42c1
   Type: SHA-1