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edu.harvard.hul.ois.jhove.module.pdf.PdfInvalidException: Invalid indirect destination - referenced object 'bib47' cannot be found Offset: 4372945 ID: PDF-HUL-122 ErrorMessage: edu.harvard.hul.ois.jhove.module.pdf.PdfInvalidException: Invalid indirect destination - referenced object 'bib47' cannot be found Offset: 4372945 MIMEtype: application/pdf Profile: Linearized PDF PDFMetadata: Objects: 1005 FreeObjects: 1 IncrementalUpdates: 1 DocumentCatalog: PageLayout: SinglePage PageMode: UseOutlines Outlines: Item: Title: Conformational Sensors and Domain Swapping Reveal Structural and Functional Differences between β-Arrestin Isoforms Children: Item: Title: Introduction Destination: edu.harvard.hul.ois.jhove.module.pdf.PdfSimpleObject@1060b431 Item: Title: Results Destination: edu.harvard.hul.ois.jhove.module.pdf.PdfSimpleObject@612679d6 Children: Item: Title: Sequence and Structural Analysis of βarrs Destination: edu.harvard.hul.ois.jhove.module.pdf.PdfSimpleObject@11758f2a Item: Title: Fab30 as a Sensor of βarr Activation Reveals Overall Similarity between V2Rpp-Bound βarr1 and 2 Destination: edu.harvard.hul.ois.jhove.module.pdf.PdfSimpleObject@e720b71 Item: Title: Fab30 Reactivity Suggests Potential Conformational Differences between Receptor-Bound βarr1 and 2 Destination: edu.harvard.hul.ois.jhove.module.pdf.PdfSimpleObject@1b26f7b2 Item: Title: Fab30 Reactivity toward βarr1 and 2 in the Presence of Homogenously Phosphorylated Receptors Destination: edu.harvard.hul.ois.jhove.module.pdf.PdfSimpleObject@491cc5c9 Item: Title: Corroborating Evidence for Potential Conformation Differences between βarr1 and 2 Destination: edu.harvard.hul.ois.jhove.module.pdf.PdfSimpleObject@74ad1f1f Item: Title: Structural Insights into Conformational Differences between Receptor-Bound βarrs Destination: edu.harvard.hul.ois.jhove.module.pdf.PdfSimpleObject@6a1aab78 Item: Title: Distal C-Domain in βarrs Is Important for the Structural Differences between the Two Isoforms Destination: edu.harvard.hul.ois.jhove.module.pdf.PdfSimpleObject@462d5aee Item: Title: A Potential Link between βarr Conformations and Their Distinct Functional Contributions Destination: edu.harvard.hul.ois.jhove.module.pdf.PdfSimpleObject@69b0fd6f Item: Title: Discussion Destination: edu.harvard.hul.ois.jhove.module.pdf.PdfSimpleObject@757942a1 Item: Title: Supplemental Information Destination: edu.harvard.hul.ois.jhove.module.pdf.PdfSimpleObject@4a87761d Item: Title: Acknowledgments Destination: edu.harvard.hul.ois.jhove.module.pdf.PdfSimpleObject@66d1af89 Item: Title: Author Contributions Destination: edu.harvard.hul.ois.jhove.module.pdf.PdfSimpleObject@8646db9 Item: Title: Declaration of Interests Destination: edu.harvard.hul.ois.jhove.module.pdf.PdfSimpleObject@37374a5e Item: Title: References Destination: edu.harvard.hul.ois.jhove.module.pdf.PdfSimpleObject@4671e53b Item: Title: STAR★Methods Destination: edu.harvard.hul.ois.jhove.module.pdf.PdfSimpleObject@2db7a79b Children: Item: Title: Key Resources Table Destination: edu.harvard.hul.ois.jhove.module.pdf.PdfSimpleObject@6950e31 Item: Title: Lead Contact and Materials Availability Destination: edu.harvard.hul.ois.jhove.module.pdf.PdfSimpleObject@b7dd107 Item: Title: Experiment Model and Subject Details Destination: edu.harvard.hul.ois.jhove.module.pdf.PdfSimpleObject@42eca56e Children: Item: Title: Bacterial cell culture Destination: edu.harvard.hul.ois.jhove.module.pdf.PdfSimpleObject@52f759d7 Item: Title: Mammalian cell culture Destination: edu.harvard.hul.ois.jhove.module.pdf.PdfSimpleObject@7cbd213e Item: Title: Insect cell culture Destination: edu.harvard.hul.ois.jhove.module.pdf.PdfSimpleObject@192d3247 Item: Title: Method Details Destination: edu.harvard.hul.ois.jhove.module.pdf.PdfSimpleObject@3ecd23d9 Children: Item: Title: Construct design and protein expression Destination: edu.harvard.hul.ois.jhove.module.pdf.PdfSimpleObject@569cfc36 Item: Title: Sequence and structural analysis of βarrs Destination: edu.harvard.hul.ois.jhove.module.pdf.PdfSimpleObject@43bd930a Item: Title: ELISA assay Destination: edu.harvard.hul.ois.jhove.module.pdf.PdfSimpleObject@33723e30 Item: Title: Co-immunoprecipitation assay Destination: edu.harvard.hul.ois.jhove.module.pdf.PdfSimpleObject@64f6106c Item: Title: Sortase ligation protocol Destination: edu.harvard.hul.ois.jhove.module.pdf.PdfSimpleObject@553a3d88 Item: Title: Confocal microscopy Destination: edu.harvard.hul.ois.jhove.module.pdf.PdfSimpleObject@7a30d1e6 Item: Title: Bimane fluorescence assay Destination: edu.harvard.hul.ois.jhove.module.pdf.PdfSimpleObject@5891e32e Item: Title: Functional assays Destination: edu.harvard.hul.ois.jhove.module.pdf.PdfSimpleObject@cb0ed20 Item: Title: Negative staining single particle analysis of β2V2R-βarrswap2-Fab30 complex Destination: edu.harvard.hul.ois.jhove.module.pdf.PdfSimpleObject@8e24743 Item: Title: MD simulation set-up and analysis Destination: 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between β-Arrestin Isoforms Eshan Ghosh Hemlata Dwivedi Mithu Baidya Ashish Srivastava Punita Kumari Tomek Stepniewski Hee Ryung Kim Mi-Hye Lee Jaana van Gastel Madhu Chaturvedi Debarati Roy Shubhi Pandey Jagannath Maharana Ramon Guixà-González Louis M. Luttrell Ka Young Chung Somnath Dutta Jana Selent Arun K. Shukla GPCRs β-arrestins cellular signaling antibody fragments biosensors biased agonism desensitization negative staining electron microscopy CellReports, 28 (2019) 3287-3305. doi:10.1016/j.celrep.2019.08.053 ElsevierCompany. journal CellReports © 2019 The Author(s). 2211-1247 28 13 24 September 2019 2019-09-24 3287-3299.e6 3287 3299.e6 10.1016/j.celrep.2019.08.053 https://doi.org/10.1016/j.celrep.2019.08.053 2010-04-23 true 10.1016/j.celrep.2019.08.053 elsevier.com sciencedirect.com VoR 10.1016/j.celrep.2019.08.053 noindex true 2010-04-23 true 20th September 2019 sciencedirect.com elsevier.com Elsevier 2019-09-23T12:02:17+05:30 2019-09-23T12:02:17+05:30 True 20th September 2019 Acrobat Distiller 8.1.0 (Windows) uuid:3916d265-42fb-4cc8-b097-816625ec84fd uuid:5ca040b9-7614-4798-b3e0-424656a08581 http://creativecommons.org/licenses/by/4.0/ Pages: Page: Label: 3287 Sequence: 1 Annotations: Annotation: Subtype: Link Rect: 354, 510, 440, 520 Annotation: Subtype: Link Rect: 100, 48, 271, 56 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