5a6fd9f85c90f941562b0f6d1bac50ed  226351.pdf
39ad270d735e2f1dcae864909e964c1d9e866785  226351.pdf
1008d58d896d7e4abdded94569dcf2ed6b5dbabfc49ad5a9d0391f626f353467  226351.pdf

Title:          Plasma Androgen Receptor and Docetaxel for Metastatic Castration-resistant Prostate Cancer
Subject:        European Urology, 75 (2019) 368-373. doi:10.1016/j.eururo.2018.09.049
Author:         Vincenza Conteduca
Creator:        Elsevier
Producer:       Acrobat Distiller 9.0.0 (Windows)
CreationDate:   Tue Jan 29 10:04:35 2019 CET
ModDate:        Tue Jan 29 10:04:35 2019 CET
Tagged:         no
UserProperties: no
Suspects:       no
Form:           none
JavaScript:     no
Pages:          6
Encrypted:      no
Page size:      595.276 x 793.701 pts
Page rot:       0
File size:      1432267 bytes
Optimized:      yes
PDF version:    1.7


name                                 type              encoding         emb sub uni object ID
------------------------------------ ----------------- ---------------- --- --- --- ---------
HILCMN+AdvOT863180fb                 Type 1C           WinAnsi          yes yes no     213  0
HILDAF+AdvP4DF60E                    Type 1C           MacRoman         yes yes no     240  0
HILCMO+AdvOT18499c10.B               Type 1C           WinAnsi          yes yes no     214  0
HILCNP+AdvP4DF612                    Type 1C           WinAnsi          yes yes no     215  0
HILCOA+AdvP4C4E74                    Type 1C           Custom           yes yes yes    216  0
HILCOB+AdvOTf2586c63.I               Type 1C           WinAnsi          yes yes no     229  0
HILCPB+AdvOTf2586c63.I+20            Type 1C           WinAnsi          yes yes no     228  0
HILCPC+AdvOT863180fb+20              Type 1C           WinAnsi          yes yes no     232  0
HILCPD+AdvP8CAA                      Type 1C           WinAnsi          yes yes no     233  0
HILDAE+AdvOT863180fb+fb              Type 1C           Custom           yes yes yes    234  0
HILDID+AdvP4C4E51                    Type 1C           WinAnsi          yes yes no      76  0
HILDKD+AdvP48722B                    Type 1C           WinAnsi          yes yes no      85  0
HINHMH+AdvOT18499c10.B+20            Type 1C           WinAnsi          yes yes no      82  0
HINHMI+AdvOT1be73566.BI              Type 1C           WinAnsi          yes yes no      79  0


Jhove (Rel. 1.22.1, 2019-04-17)
 Date: 2021-06-29 02:41:34 CEST
 RepresentationInformation: 226351.pdf
  ReportingModule: PDF-hul, Rel. 1.12.1 (2019-04-17)
  LastModified: 2021-06-28 20:15:21 CEST
  Size: 1432267
  Format: PDF
  Version: 1.7
  Status: Well-Formed, but not valid
  SignatureMatches:
   PDF-hul
  ID: PDF-HUL-122
  ErrorMessage: edu.harvard.hul.ois.jhove.module.pdf.PdfInvalidException: Invalid indirect destination - referenced object 'Raff0005' cannot be found
   Offset: 1417804
  ID: PDF-HUL-122
  ErrorMessage: edu.harvard.hul.ois.jhove.module.pdf.PdfInvalidException: Invalid indirect destination - referenced object 'Raff0010' cannot be found
   Offset: 1417804
  ID: PDF-HUL-122
  ErrorMessage: edu.harvard.hul.ois.jhove.module.pdf.PdfInvalidException: Invalid indirect destination - referenced object 'Rfn1' cannot be found
   Offset: 1417804
  ID: PDF-HUL-122
  ErrorMessage: edu.harvard.hul.ois.jhove.module.pdf.PdfInvalidException: Invalid indirect destination - referenced object 'Rcor0005' cannot be found
   Offset: 1417804
  ID: PDF-HUL-122
  ErrorMessage: edu.harvard.hul.ois.jhove.module.pdf.PdfInvalidException: Invalid indirect destination - referenced object 'Raff0010' cannot be found
   Offset: 1417804
  ID: PDF-HUL-122
  ErrorMessage: edu.harvard.hul.ois.jhove.module.pdf.PdfInvalidException: Invalid indirect destination - referenced object 'Raff0015' cannot be found
   Offset: 1417804
  ID: PDF-HUL-122
  ErrorMessage: edu.harvard.hul.ois.jhove.module.pdf.PdfInvalidException: Invalid indirect destination - referenced object 'Raff0020' cannot be found
   Offset: 1417804
  ID: PDF-HUL-122
  ErrorMessage: edu.harvard.hul.ois.jhove.module.pdf.PdfInvalidException: Invalid indirect destination - referenced object 'Rfn1' cannot be found
   Offset: 1417804
  ID: PDF-HUL-122
  ErrorMessage: edu.harvard.hul.ois.jhove.module.pdf.PdfInvalidException: Invalid indirect destination - referenced object 'Raff0025' cannot be found
   Offset: 1417804
  ID: PDF-HUL-122
  ErrorMessage: edu.harvard.hul.ois.jhove.module.pdf.PdfInvalidException: Invalid indirect destination - referenced object 'Raff0030' cannot be found
   Offset: 1417804
  ID: PDF-HUL-122
  ErrorMessage: edu.harvard.hul.ois.jhove.module.pdf.PdfInvalidException: Invalid indirect destination - referenced object 'Rfn1' cannot be found
   Offset: 1417804
  ID: PDF-HUL-122
  ErrorMessage: edu.harvard.hul.ois.jhove.module.pdf.PdfInvalidException: Invalid indirect destination - referenced object 'Raff0010' cannot be found
   Offset: 1417804
  ID: PDF-HUL-122
  ErrorMessage: edu.harvard.hul.ois.jhove.module.pdf.PdfInvalidException: Invalid indirect destination - referenced object 'Raff0020' cannot be found
   Offset: 1417804
  ID: PDF-HUL-122
  ErrorMessage: edu.harvard.hul.ois.jhove.module.pdf.PdfInvalidException: Invalid indirect destination - referenced object 'Raff0005' cannot be found
   Offset: 1417804
  ID: PDF-HUL-122
  ErrorMessage: edu.harvard.hul.ois.jhove.module.pdf.PdfInvalidException: Invalid indirect destination - referenced object 'Raff0025' cannot be found
   Offset: 1417804
  ID: PDF-HUL-122
  ErrorMessage: edu.harvard.hul.ois.jhove.module.pdf.PdfInvalidException: Invalid indirect destination - referenced object 'Raff0035' cannot be found
   Offset: 1417804
  ID: PDF-HUL-122
  ErrorMessage: edu.harvard.hul.ois.jhove.module.pdf.PdfInvalidException: Invalid indirect destination - referenced object 'Raff0040' cannot be found
   Offset: 1417804
  ID: PDF-HUL-122
  ErrorMessage: edu.harvard.hul.ois.jhove.module.pdf.PdfInvalidException: Invalid indirect destination - referenced object 'Raff0005' cannot be found
   Offset: 1417804
  ID: PDF-HUL-122
  ErrorMessage: edu.harvard.hul.ois.jhove.module.pdf.PdfInvalidException: Invalid indirect destination - referenced object 'Raff0010' cannot be found
   Offset: 1417804
  ID: PDF-HUL-122
  ErrorMessage: edu.harvard.hul.ois.jhove.module.pdf.PdfInvalidException: Invalid indirect destination - referenced object 'Raff0020' cannot be found
   Offset: 1417804
  ID: PDF-HUL-122
  ErrorMessage: edu.harvard.hul.ois.jhove.module.pdf.PdfInvalidException: Invalid indirect destination - referenced object 'Raff0005' cannot be found
   Offset: 1417804
  ID: PDF-HUL-122
  ErrorMessage: edu.harvard.hul.ois.jhove.module.pdf.PdfInvalidException: Invalid indirect destination - referenced object 'Raff0045' cannot be found
   Offset: 1417804
  ID: PDF-HUL-122
  ErrorMessage: edu.harvard.hul.ois.jhove.module.pdf.PdfInvalidException: Invalid indirect destination - referenced object 'Raff0050' cannot be found
   Offset: 1417804
  ID: PDF-HUL-122
  ErrorMessage: edu.harvard.hul.ois.jhove.module.pdf.PdfInvalidException: Invalid indirect destination - referenced object 'Raff0055' cannot be found
   Offset: 1417804
  ID: PDF-HUL-122
  ErrorMessage: edu.harvard.hul.ois.jhove.module.pdf.PdfInvalidException: Invalid indirect destination - referenced object 'Raff0060' cannot be found
   Offset: 1417804
  ID: PDF-HUL-122
  ErrorMessage: edu.harvard.hul.ois.jhove.module.pdf.PdfInvalidException: Invalid indirect destination - referenced object 'Raff0065' cannot be found
   Offset: 1417804
  ID: PDF-HUL-122
  ErrorMessage: edu.harvard.hul.ois.jhove.module.pdf.PdfInvalidException: Invalid indirect destination - referenced object 'Raff0070' cannot be found
   Offset: 1417804
  ID: PDF-HUL-122
  ErrorMessage: edu.harvard.hul.ois.jhove.module.pdf.PdfInvalidException: Invalid indirect destination - referenced object 'Raff0075' cannot be found
   Offset: 1417804
  ID: PDF-HUL-122
  ErrorMessage: edu.harvard.hul.ois.jhove.module.pdf.PdfInvalidException: Invalid indirect destination - referenced object 'Raff0080' cannot be found
   Offset: 1417804
  ID: PDF-HUL-122
  ErrorMessage: edu.harvard.hul.ois.jhove.module.pdf.PdfInvalidException: Invalid indirect destination - referenced object 'Raff0040' cannot be found
   Offset: 1417804
  ID: PDF-HUL-122
  ErrorMessage: edu.harvard.hul.ois.jhove.module.pdf.PdfInvalidException: Invalid indirect destination - referenced object 'Raff0085' cannot be found
   Offset: 1417804
  ID: PDF-HUL-122
  ErrorMessage: edu.harvard.hul.ois.jhove.module.pdf.PdfInvalidException: Invalid indirect destination - referenced object 'Raff0090' cannot be found
   Offset: 1417804
  ID: PDF-HUL-122
  ErrorMessage: edu.harvard.hul.ois.jhove.module.pdf.PdfInvalidException: Invalid indirect destination - referenced object 'Raff0025' cannot be found
   Offset: 1417804
  ID: PDF-HUL-122
  ErrorMessage: edu.harvard.hul.ois.jhove.module.pdf.PdfInvalidException: Invalid indirect destination - referenced object 'Raff0095' cannot be found
   Offset: 1417804
  ID: PDF-HUL-122
  ErrorMessage: edu.harvard.hul.ois.jhove.module.pdf.PdfInvalidException: Invalid indirect destination - referenced object 'Rfn2' cannot be found
   Offset: 1417804
  ID: PDF-HUL-122
  ErrorMessage: edu.harvard.hul.ois.jhove.module.pdf.PdfInvalidException: Invalid indirect destination - referenced object 'Raff0010' cannot be found
   Offset: 1417804
  ID: PDF-HUL-122
  ErrorMessage: edu.harvard.hul.ois.jhove.module.pdf.PdfInvalidException: Invalid indirect destination - referenced object 'Raff0015' cannot be found
   Offset: 1417804
  ID: PDF-HUL-122
  ErrorMessage: edu.harvard.hul.ois.jhove.module.pdf.PdfInvalidException: Invalid indirect destination - referenced object 'Raff0020' cannot be found
   Offset: 1417804
  ID: PDF-HUL-122
  ErrorMessage: edu.harvard.hul.ois.jhove.module.pdf.PdfInvalidException: Invalid indirect destination - referenced object 'Rfn2' cannot be found
   Offset: 1417804
  ID: PDF-HUL-122
  ErrorMessage: edu.harvard.hul.ois.jhove.module.pdf.PdfInvalidException: Invalid indirect destination - referenced object 'Rcor0005' cannot be found
   Offset: 1417804
  ID: PDF-HUL-122
  ErrorMessage: edu.harvard.hul.ois.jhove.module.pdf.PdfInvalidException: Invalid indirect destination - referenced object 'Raff0005' cannot be found
   Offset: 1417804
  ID: PDF-HUL-122
  ErrorMessage: edu.harvard.hul.ois.jhove.module.pdf.PdfInvalidException: Invalid indirect destination - referenced object 'Rfn2' cannot be found
   Offset: 1417804
  ID: PDF-HUL-122
  ErrorMessage: edu.harvard.hul.ois.jhove.module.pdf.PdfInvalidException: Invalid indirect destination - referenced object 'Rbib0055' cannot be found
   Offset: 1417804
  ID: PDF-HUL-122
  ErrorMessage: edu.harvard.hul.ois.jhove.module.pdf.PdfInvalidException: Invalid indirect destination - referenced object 'Rbib0055' cannot be found
   Offset: 1417804
  ID: PDF-HUL-122
  ErrorMessage: edu.harvard.hul.ois.jhove.module.pdf.PdfInvalidException: Invalid indirect destination - referenced object 'Rbib0080' cannot be found
   Offset: 1417804
  ID: PDF-HUL-122
  ErrorMessage: edu.harvard.hul.ois.jhove.module.pdf.PdfInvalidException: Invalid indirect destination - referenced object 'Rbib0090' cannot be found
   Offset: 1417804
  ID: PDF-HUL-122
  ErrorMessage: edu.harvard.hul.ois.jhove.module.pdf.PdfInvalidException: Invalid indirect destination - referenced object 'Rbib0075' cannot be found
   Offset: 1417804
  ID: PDF-HUL-122
  ErrorMessage: edu.harvard.hul.ois.jhove.module.pdf.PdfInvalidException: Invalid indirect destination - referenced object 'Rfig0005' cannot be found
   Offset: 1417804
  ID: PDF-HUL-122
  ErrorMessage: edu.harvard.hul.ois.jhove.module.pdf.PdfInvalidException: Invalid indirect destination - referenced object 'Rfig0005' cannot be found
   Offset: 1417804
  ID: PDF-HUL-122
  ErrorMessage: edu.harvard.hul.ois.jhove.module.pdf.PdfInvalidException: Invalid indirect destination - referenced object 'Rfig0005' cannot be found
   Offset: 1417804
  ID: PDF-HUL-122
  ErrorMessage: edu.harvard.hul.ois.jhove.module.pdf.PdfInvalidException: Invalid indirect destination - referenced object 'Rbib0075' cannot be found
   Offset: 1417804
  ID: PDF-HUL-122
  ErrorMessage: edu.harvard.hul.ois.jhove.module.pdf.PdfInvalidException: Invalid indirect destination - referenced object 'Rfig0010' cannot be found
   Offset: 1417804
  ID: PDF-HUL-122
  ErrorMessage: edu.harvard.hul.ois.jhove.module.pdf.PdfInvalidException: Invalid indirect destination - referenced object 'Rfig0010' cannot be found
   Offset: 1417804
  ID: PDF-HUL-122
  ErrorMessage: edu.harvard.hul.ois.jhove.module.pdf.PdfInvalidException: Invalid indirect destination - referenced object 'Rfig0010' cannot be found
   Offset: 1417804
  ID: PDF-HUL-122
  ErrorMessage: edu.harvard.hul.ois.jhove.module.pdf.PdfInvalidException: Invalid indirect destination - referenced object 'Rfig0010' cannot be found
   Offset: 1417804
  ID: PDF-HUL-122
  ErrorMessage: edu.harvard.hul.ois.jhove.module.pdf.PdfInvalidException: Invalid indirect destination - referenced object 'Rfig0010' cannot be found
   Offset: 1417804
  ID: PDF-HUL-122
  ErrorMessage: edu.harvard.hul.ois.jhove.module.pdf.PdfInvalidException: Invalid indirect destination - referenced object 'Rfig0010' cannot be found
   Offset: 1417804
  ID: PDF-HUL-122
  ErrorMessage: edu.harvard.hul.ois.jhove.module.pdf.PdfInvalidException: Invalid indirect destination - referenced object 'Rbib0075' cannot be found
   Offset: 1417804
  ID: PDF-HUL-122
  ErrorMessage: edu.harvard.hul.ois.jhove.module.pdf.PdfInvalidException: Invalid indirect destination - referenced object 'Rbib0060' cannot be found
   Offset: 1417804
  ID: PDF-HUL-122
  ErrorMessage: edu.harvard.hul.ois.jhove.module.pdf.PdfInvalidException: Invalid indirect destination - referenced object 'Rbib0095' cannot be found
   Offset: 1417804
  ID: PDF-HUL-122
  ErrorMessage: edu.harvard.hul.ois.jhove.module.pdf.PdfInvalidException: Invalid indirect destination - referenced object 'Rbib0080' cannot be found
   Offset: 1417804
  ID: PDF-HUL-122
  ErrorMessage: edu.harvard.hul.ois.jhove.module.pdf.PdfInvalidException: Invalid indirect destination - referenced object 'Rbib0100' cannot be found
   Offset: 1417804
  MIMEtype: application/pdf
  Profile: Linearized PDF
  PDFMetadata: 
   Objects: 272
   FreeObjects: 1
   IncrementalUpdates: 1
   DocumentCatalog: 
    PageLayout: SinglePage
    PageMode: UseOutlines
    Outlines: 
     Item: 
      Title: Plasma Androgen Receptor and Docetaxel for Metastatic Castration-resistant Prostate Cancer
      Destination: edu.harvard.hul.ois.jhove.module.pdf.PdfSimpleObject@612fc6eb
      Children: 
       Item: 
        Title: Appendix A Supplementary data
        Destination: edu.harvard.hul.ois.jhove.module.pdf.PdfSimpleObject@1060b431
       Item: 
        Title: References
        Destination: edu.harvard.hul.ois.jhove.module.pdf.PdfSimpleObject@612679d6
   Info: 
    Title: Plasma Androgen Receptor and Docetaxel for Metastatic Castration-resistant Prostate Cancer
    Author: Vincenza Conteduca
    Subject: European Urology, 75 (2019) 368-373. doi:10.1016/j.eururo.2018.09.049
    Creator: Elsevier
    Producer: Acrobat Distiller 9.0.0 (Windows)
    CreationDate: Tue Jan 29 10:34:35 CET 2019
    ModDate: Tue Jan 29 10:34:35 CET 2019
   ID: 0x988915d304f00fb351fabc709df3eaa2, 0x3b8b309c50af61458ee2410bd69ddfd5
   Filters: 
    FilterPipeline: FlateDecode
    FilterPipeline: DCTDecode
    FilterPipeline: CCITTFaxDecode
   Images: 
    Image: 
     NisoImageMetadata: 
      FormatName: image/jpg
      CompressionScheme: JPEG
      ImageWidth: 296
      ImageHeight: 371
      ColorSpace: RGB
      BitsPerSample: 8
      BitsPerSampleUnit: integer
    Image: 
     NisoImageMetadata: 
      FormatName: image/png
      ImageWidth: 121
      ImageHeight: 120
      BitsPerSample: 8
      BitsPerSampleUnit: integer
     Filter: FlateDecode
    Image: 
     NisoImageMetadata: 
      FormatName: image/tiff
      CompressionScheme: CCITT Group 4
      ImageWidth: 1618
      ImageHeight: 446
      BitsPerSample: 1
      BitsPerSampleUnit: integer
     ImageMask: true
    Image: 
     NisoImageMetadata: 
      FormatName: image/jpg
      CompressionScheme: JPEG
      ImageWidth: 1901
      ImageHeight: 1847
      ColorSpace: RGB
      BitsPerSample: 8
      BitsPerSampleUnit: integer
    Image: 
     NisoImageMetadata: 
      FormatName: image/jpg
      CompressionScheme: JPEG
      ImageWidth: 1901
      ImageHeight: 1327
      ColorSpace: RGB
      BitsPerSample: 8
      BitsPerSampleUnit: integer
    Image: 
     NisoImageMetadata: 
      FormatName: image/jpg
      CompressionScheme: JPEG
      ImageWidth: 2051
      ImageHeight: 1346
      ColorSpace: RGB
      BitsPerSample: 8
      BitsPerSampleUnit: integer
   Fonts: 
    Type1: 
     Font: 
      BaseFont: HILCPB+AdvOTf2586c63.I+20
      FontSubset: true
      FirstChar: 146
      LastChar: 146
      FontDescriptor: 
       FontName: HILCPB+AdvOTf2586c63.I+20
       Flags: Nonsymbolic
       FontBBox: -48, -211, 887, 789
       FontFile3: true
      Encoding: WinAnsiEncoding
     Font: 
      BaseFont: HILCOB+AdvOTf2586c63.I
      FontSubset: true
      FirstChar: 38
      LastChar: 243
      FontDescriptor: 
       FontName: HILCOB+AdvOTf2586c63.I
       Flags: Serif, Nonsymbolic
       FontBBox: -141, -232, 1053, 972
       FontFile3: true
      Encoding: WinAnsiEncoding
     Font: 
      BaseFont: HILCPC+AdvOT863180fb+20
      FontSubset: true
      FirstChar: 146
      LastChar: 151
      FontDescriptor: 
       FontName: HILCPC+AdvOT863180fb+20
       Flags: Nonsymbolic
       FontBBox: 15, -213, 956, 789
       FontFile3: true
      Encoding: WinAnsiEncoding
     Font: 
      BaseFont: HILCPD+AdvP8CAA
      FontSubset: true
      FirstChar: 46
      LastChar: 121
      FontDescriptor: 
       FontName: HILCPD+AdvP8CAA
       Flags: Nonsymbolic
       FontBBox: -145, -239, 1000, 770
       FontFile3: true
      Encoding: WinAnsiEncoding
     Font: 
      BaseFont: HILDAE+AdvOT863180fb+fb
      FontSubset: true
      FirstChar: 1
      LastChar: 3
      FontDescriptor: 
       FontName: HILDAE+AdvOT863180fb+fb
       Flags: Symbolic
       FontBBox: 48, 0, 896, 789
       FontFile3: true
      EncodingDictionary: 
       Differences: true
      ToUnicode: true
     Font: 
      BaseFont: HILDID+AdvP4C4E51
      FontSubset: true
      FirstChar: 60
      LastChar: 60
      FontDescriptor: 
       FontName: HILDID+AdvP4C4E51
       Flags: Nonsymbolic
       FontBBox: -31, -239, 1041, 750
       FontFile3: true
      Encoding: WinAnsiEncoding
     Font: 
      BaseFont: HINHMI+AdvOT1be73566.BI
      FontSubset: true
      FirstChar: 61
      LastChar: 82
      FontDescriptor: 
       FontName: HINHMI+AdvOT1be73566.BI
       Flags: Nonsymbolic
       FontBBox: -175, -248, 1120, 998
       FontFile3: true
      Encoding: WinAnsiEncoding
     Font: 
      BaseFont: HILDAF+AdvP4DF60E
      FontSubset: true
      FirstChar: 40
      LastChar: 222
      FontDescriptor: 
       FontName: HILDAF+AdvP4DF60E
       Flags: Serif, Nonsymbolic
       FontBBox: -104, -239, 1041, 822
       FontFile3: true
      Encoding: MacRomanEncoding
     Font: 
      BaseFont: HINHMH+AdvOT18499c10.B+20
      FontSubset: true
      FirstChar: 150
      LastChar: 150
      FontDescriptor: 
       FontName: HINHMH+AdvOT18499c10.B+20
       Flags: Nonsymbolic
       FontBBox: 14, -211, 1131, 789
       FontFile3: true
      Encoding: WinAnsiEncoding
     Font: 
      BaseFont: HILCMN+AdvOT863180fb
      FontSubset: true
      FirstChar: 37
      LastChar: 243
      FontDescriptor: 
       FontName: HILCMN+AdvOT863180fb
       Flags: Serif, Nonsymbolic
       FontBBox: -76, -251, 1042, 986
       FontFile3: true
      Encoding: WinAnsiEncoding
     Font: 
      BaseFont: HILDKD+AdvP48722B
      FontSubset: true
      FirstChar: 0
      LastChar: 0
      FontDescriptor: 
       FontName: HILDKD+AdvP48722B
       Flags: Nonsymbolic
       FontBBox: 0, 0, 187, 291
       FontFile3: true
      Encoding: WinAnsiEncoding
     Font: 
      BaseFont: HILCMO+AdvOT18499c10.B
      FontSubset: true
      FirstChar: 37
      LastChar: 122
      FontDescriptor: 
       FontName: HILCMO+AdvOT18499c10.B
       Flags: Serif, Nonsymbolic
       FontBBox: -98, -250, 1049, 998
       FontFile3: true
      Encoding: WinAnsiEncoding
     Font: 
      BaseFont: HILCNP+AdvP4DF612
      FontSubset: true
      FirstChar: 42
      LastChar: 180
      FontDescriptor: 
       FontName: HILCNP+AdvP4DF612
       Flags: Serif, Nonsymbolic
       FontBBox: -145, -229, 1083, 822
       FontFile3: true
      Encoding: WinAnsiEncoding
     Font: 
      BaseFont: HILCOA+AdvP4C4E74
      FontSubset: true
      FirstChar: 2
      LastChar: 122
      FontDescriptor: 
       FontName: HILCOA+AdvP4C4E74
       Flags: Symbolic
       FontBBox: -20, -958, 1114, 770
       FontFile3: true
      EncodingDictionary: 
       Differences: true
      ToUnicode: true
   XMP: <x:xmpmeta xmlns:x="adobe:ns:meta/" x:xmptk="Adobe XMP Core 4.2.1-c041 52.342996, 2008/05/07-20:48:00        ">
   <rdf:RDF xmlns:rdf="http://www.w3.org/1999/02/22-rdf-syntax-ns#">
      <rdf:Description rdf:about=""
            xmlns:dc="http://purl.org/dc/elements/1.1/">
         <dc:format>application/pdf</dc:format>
         <dc:identifier>10.1016/j.eururo.2018.09.049</dc:identifier>
         <dc:title>
            <rdf:Alt>
               <rdf:li xml:lang="x-default">Plasma Androgen Receptor and Docetaxel for Metastatic Castration-resistant Prostate Cancer</rdf:li>
            </rdf:Alt>
         </dc:title>
         <dc:creator>
            <rdf:Seq>
               <rdf:li>Vincenza Conteduca</rdf:li>
               <rdf:li>Anuradha Jayaram</rdf:li>
               <rdf:li>Nuria Romero-Laorden</rdf:li>
               <rdf:li>Daniel Wetterskog</rdf:li>
               <rdf:li>Samanta Salvi</rdf:li>
               <rdf:li>Giorgia Gurioli</rdf:li>
               <rdf:li>Emanuela Scarpi</rdf:li>
               <rdf:li>Elena Castro</rdf:li>
               <rdf:li>Mercedes Marin-Aguilera</rdf:li>
               <rdf:li>Cristian Lolli</rdf:li>
               <rdf:li>Giuseppe Schepisi</rdf:li>
               <rdf:li>Antonio Maugeri</rdf:li>
               <rdf:li>Anna Wingate</rdf:li>
               <rdf:li>Alberto Farolfi</rdf:li>
               <rdf:li>Valentina Casadio</rdf:li>
               <rdf:li>Ana Medina</rdf:li>
               <rdf:li>Javier Puente</rdf:li>
               <rdf:li>Mª José Méndez Vidal</rdf:li>
               <rdf:li>Rafael Morales-Barrera</rdf:li>
               <rdf:li>Jose C. Villa-Guzmán</rdf:li>
               <rdf:li>Susana Hernando</rdf:li>
               <rdf:li>Alejo Rodriguez-Vida</rdf:li>
               <rdf:li>Aránzazu González-del-Alba</rdf:li>
               <rdf:li>Begoña Mellado</rdf:li>
               <rdf:li>Enrique Gonzalez-Billalabeitia</rdf:li>
               <rdf:li>David Olmos</rdf:li>
               <rdf:li>Gerhardt Attard</rdf:li>
               <rdf:li>Ugo De Giorgi</rdf:li>
            </rdf:Seq>
         </dc:creator>
         <dc:subject>
            <rdf:Bag>
               <rdf:li>Castration-resistant prostate cancer</rdf:li>
               <rdf:li>Androgen receptor</rdf:li>
               <rdf:li>Plasma DNA</rdf:li>
               <rdf:li>Docetaxel</rdf:li>
               <rdf:li>Androgen receptor–directed therapies</rdf:li>
               <rdf:li>Biomarker</rdf:li>
            </rdf:Bag>
         </dc:subject>
         <dc:description>
            <rdf:Alt>
               <rdf:li xml:lang="x-default">European Urology, 75 (2019) 368-373. doi:10.1016/j.eururo.2018.09.049</rdf:li>
            </rdf:Alt>
         </dc:description>
         <dc:publisher>
            <rdf:Bag>
               <rdf:li>The Authors</rdf:li>
            </rdf:Bag>
         </dc:publisher>
      </rdf:Description>
      <rdf:Description rdf:about=""
            xmlns:prism="http://prismstandard.org/namespaces/basic/3.0/">
         <prism:aggregationType>journal</prism:aggregationType>
         <prism:publicationName>European Urology</prism:publicationName>
         <prism:copyright>© 2018 The Authors. Published by Elsevier B.V. on behalf of European Association of Urology.</prism:copyright>
         <prism:issn>0302-2838</prism:issn>
         <prism:volume>75</prism:volume>
         <prism:number>3</prism:number>
         <prism:coverDisplayDate>March 2019</prism:coverDisplayDate>
         <prism:pageRange>368-373</prism:pageRange>
         <prism:startingPage>368</prism:startingPage>
         <prism:endingPage>373</prism:endingPage>
         <prism:doi>10.1016/j.eururo.2018.09.049</prism:doi>
         <prism:url>https://doi.org/10.1016/j.eururo.2018.09.049</prism:url>
      </rdf:Description>
      <rdf:Description rdf:about=""
            xmlns:crossmark="http://crossref.org/crossmark/1.0/">
         <crossmark:MajorVersionDate>2010-04-23</crossmark:MajorVersionDate>
         <crossmark:CrossmarkDomainExclusive>true</crossmark:CrossmarkDomainExclusive>
         <crossmark:DOI>10.1016/j.eururo.2018.09.049</crossmark:DOI>
         <crossmark:CrossMarkDomains>
            <rdf:Seq>
               <rdf:li>elsevier.com</rdf:li>
               <rdf:li>sciencedirect.com</rdf:li>
            </rdf:Seq>
         </crossmark:CrossMarkDomains>
      </rdf:Description>
      <rdf:Description rdf:about=""
            xmlns:jav="http://www.niso.org/schemas/jav/1.0/">
         <jav:journal_article_version>VoR</jav:journal_article_version>
      </rdf:Description>
      <rdf:Description rdf:about=""
            xmlns:pdfx="http://ns.adobe.com/pdfx/1.3/">
         <d2UUdmdn8od2KnMqGmPiOnLNNnM-QlwiOyPmGy.n7n9yQmdz9n.uRo9ePm9qRot6SmdeTma/>
         <pdfx:doi>10.1016/j.eururo.2018.09.049</pdfx:doi>
         <pdfx:robots>noindex</pdfx:robots>
         <pdfx:CrossmarkMajorVersionDate>2010-04-23</pdfx:CrossmarkMajorVersionDate>
         <pdfx:CrossmarkDomainExclusive>true</pdfx:CrossmarkDomainExclusive>
         <pdfx:CrossMarkDomains>
            <rdf:Seq>
               <rdf:li>sciencedirect.com</rdf:li>
               <rdf:li>elsevier.com</rdf:li>
            </rdf:Seq>
         </pdfx:CrossMarkDomains>
      </rdf:Description>
      <rdf:Description rdf:about=""
            xmlns:xmp="http://ns.adobe.com/xap/1.0/">
         <xmp:CreatorTool>Elsevier</xmp:CreatorTool>
         <xmp:CreateDate>2019-01-29T14:34:35+05:30</xmp:CreateDate>
         <xmp:ModifyDate>2019-01-29T14:34:35+05:30</xmp:ModifyDate>
      </rdf:Description>
      <rdf:Description rdf:about=""
            xmlns:xmpRights="http://ns.adobe.com/xap/1.0/rights/">
         <xmpRights:Marked>True</xmpRights:Marked>
      </rdf:Description>
      <rdf:Description rdf:about=""
            xmlns:pdf="http://ns.adobe.com/pdf/1.3/">
         <pdf:Producer>Acrobat Distiller 9.0.0 (Windows)</pdf:Producer>
      </rdf:Description>
      <rdf:Description rdf:about=""
            xmlns:xmpMM="http://ns.adobe.com/xap/1.0/mm/">
         <xmpMM:DocumentID>uuid:aca74bf9-d08d-43e9-bb43-bf375ea990a5</xmpMM:DocumentID>
         <xmpMM:InstanceID>uuid:3df736f7-0fca-4e9e-989a-c220c77a860d</xmpMM:InstanceID>
      </rdf:Description>
      <rdf:Description rdf:about=""
            xmlns:ali="http://www.niso.org/schemas/ali/1.0/">
         <ali:license_ref>
            <rdf:Bag>
               <rdf:li rdf:parseType="Resource">
                  <ali:uri>http://creativecommons.org/licenses/by/4.0/</ali:uri>
               </rdf:li>
            </rdf:Bag>
         </ali:license_ref>
      </rdf:Description>
   </rdf:RDF>
</x:xmpmeta>
   Pages: 
    Page: 
     Label: 368
     Sequence: 1
     Annotations: 
      Annotation: 
       Subtype: Link
       Rect: 154, 541, 161, 552
       Destination: null
      Annotation: 
       Subtype: Link
       Rect: 161, 541, 168, 552
       Destination: null
      Annotation: 
       Subtype: Link
       Rect: 168, 541, 174, 552
       Destination: null
      Annotation: 
       Subtype: Link
       Rect: 174, 536, 287, 547
       Destination: null
      Annotation: 
       Subtype: Link
       Rect: 287, 541, 294, 552
       Destination: null
      Annotation: 
       Subtype: Link
       Rect: 294, 541, 300, 552
       Destination: null
      Annotation: 
       Subtype: Link
       Rect: 300, 541, 307, 552
       Destination: null
      Annotation: 
       Subtype: Link
       Rect: 307, 536, 440, 547
       Destination: null
      Annotation: 
       Subtype: Link
       Rect: 440, 541, 446, 552
       Destination: null
      Annotation: 
       Subtype: Link
       Rect: 446, 541, 451, 552
       Destination: null
      Annotation: 
       Subtype: Link
       Rect: 451, 536, 461, 547
       Destination: null
      Annotation: 
       Subtype: Link
       Rect: 146, 527, 153, 538
       Destination: null
      Annotation: 
       Subtype: Link
       Rect: 153, 522, 241, 533
       Destination: null
      Annotation: 
       Subtype: Link
       Rect: 241, 522, 514, 533
       Destination: null
      Annotation: 
       Subtype: Link
       Rect: 514, 527, 520, 538
       Destination: null
      Annotation: 
       Subtype: Link
       Rect: 520, 522, 527, 533
       Destination: null
      Annotation: 
       Subtype: Link
       Rect: 182, 508, 262, 519
       Destination: null
      Annotation: 
       Subtype: Link
       Rect: 262, 508, 481, 519
       Destination: null
      Annotation: 
       Subtype: Link
       Rect: 124, 499, 131, 510
       Destination: null
      Annotation: 
       Subtype: Link
       Rect: 131, 494, 220, 505
       Destination: null
      Annotation: 
       Subtype: Link
       Rect: 220, 494, 406, 505
       Destination: null
      Annotation: 
       Subtype: Link
       Rect: 406, 494, 486, 505
       Destination: null
      Annotation: 
       Subtype: Link
       Rect: 486, 494, 495, 505
       Destination: null
      Annotation: 
       Subtype: Link
       Rect: 163, 480, 300, 491
       Destination: null
      Annotation: 
       Subtype: Link
       Rect: 300, 480, 420, 491
       Destination: null
      Annotation: 
       Subtype: Link
       Rect: 420, 480, 529, 491
       Destination: null
      Annotation: 
       Subtype: Link
       Rect: 529, 480, 537, 491
       Destination: null
      Annotation: 
       Subtype: Link
       Rect: 159, 466, 320, 476
       Destination: null
      Annotation: 
       Subtype: Link
       Rect: 320, 466, 417, 476
       Destination: null
      Annotation: 
       Subtype: Link
       Rect: 417, 466, 428, 476
       Destination: null
      Annotation: 
       Subtype: Link
       Rect: 207, 456, 214, 467
       Destination: null
      Annotation: 
       Subtype: Link
       Rect: 214, 451, 293, 462
       Destination: null
      Annotation: 
       Subtype: Link
       Rect: 293, 456, 299, 467
       Destination: null
      Annotation: 
       Subtype: Link
       Rect: 299, 456, 305, 467
       Destination: null
      Annotation: 
       Subtype: Link
       Rect: 305, 451, 402, 462
       Destination: null
      Annotation: 
       Subtype: Link
       Rect: 402, 456, 408, 467
       Destination: null
      Annotation: 
       Subtype: Link
       Rect: 408, 456, 414, 467
       Destination: null
      Annotation: 
       Subtype: Link
       Rect: 414, 456, 421, 467
       Destination: null
      Annotation: 
       Subtype: Link
       Rect: 421, 456, 427, 467
       Destination: null
      Annotation: 
       Subtype: Link
       Rect: 427, 451, 513, 462
       Destination: null
      Annotation: 
       Subtype: Link
       Rect: 513, 456, 520, 467
       Destination: null
      Annotation: 
       Subtype: Link
       Rect: 520, 451, 524, 462
       Destination: null
      Annotation: 
       Subtype: Link
       Rect: 212, 753, 378, 759
      Annotation: 
       Subtype: Link
       Rect: 272, 97, 377, 104
      Annotation: 
       Subtype: Link
       Rect: 433, 97, 494, 104
      Annotation: 
       Subtype: Link
       Rect: 47, 58, 194, 65
      Annotation: 
       Subtype: Link
       Rect: 133, 40, 281, 47
      Annotation: 
       Subtype: Link
       Rect: 515, 37, 543, 65
    Page: 
     Label: 369
     Sequence: 2
     Annotations: 
      Annotation: 
       Subtype: Link
       Rect: 277, 431, 291, 439
       Destination: null
      Annotation: 
       Subtype: Link
       Rect: 51, 419, 60, 428
       Destination: null
      Annotation: 
       Subtype: Link
       Rect: 236, 396, 255, 405
       Destination: null
      Annotation: 
       Subtype: Link
       Rect: 141, 246, 152, 255
       Destination: null
      Annotation: 
       Subtype: Link
       Rect: 279, 223, 291, 231
       Destination: null
      Annotation: 
       Subtype: Link
       Rect: 173, 96, 195, 104
       Destination: null
      Annotation: 
       Subtype: Link
       Rect: 488, 350, 510, 358
       Destination: null
      Annotation: 
       Subtype: Link
       Rect: 516, 304, 538, 312
       Destination: null
      Annotation: 
       Subtype: Link
       Rect: 308, 292, 320, 301
       Destination: null
      Annotation: 
       Subtype: Link
       Rect: 487, 50, 547, 58
       Destination: null
      Annotation: 
       Subtype: Link
       Rect: 453, 549, 547, 557
      Annotation: 
       Subtype: Link
       Rect: 467, 537, 543, 545
    Page: 
     Label: 370
     Sequence: 3
     Annotations: 
      Annotation: 
       Subtype: Link
       Rect: 47, 199, 57, 207
       Destination: null
      Annotation: 
       Subtype: Link
       Rect: 183, 199, 205, 207
       Destination: null
      Annotation: 
       Subtype: Link
       Rect: 254, 199, 276, 207
       Destination: null
      Annotation: 
       Subtype: Link
       Rect: 237, 106, 259, 115
       Destination: null
      Annotation: 
       Subtype: Link
       Rect: 47, 83, 73, 92
       Destination: null
      Annotation: 
       Subtype: Link
       Rect: 427, 199, 439, 207
       Destination: null
      Annotation: 
       Subtype: Link
       Rect: 383, 95, 405, 103
       Destination: null
      Annotation: 
       Subtype: Link
       Rect: 342, 49, 354, 57
       Destination: null
    Page: 
     Label: 371
     Sequence: 4
     Annotations: 
      Annotation: 
       Subtype: Link
       Rect: 51, 279, 70, 288
       Destination: null
      Annotation: 
       Subtype: Link
       Rect: 254, 221, 270, 230
       Destination: null
    Page: 
     Label: 372
     Sequence: 5
     Annotations: 
      Annotation: 
       Subtype: Link
       Rect: 443, 245, 543, 253
      Annotation: 
       Subtype: Link
       Rect: 304, 233, 382, 242
      Annotation: 
       Subtype: Link
       Rect: 320, 188, 543, 195
      Annotation: 
       Subtype: Link
       Rect: 320, 178, 543, 185
      Annotation: 
       Subtype: Link
       Rect: 320, 167, 505, 174
      Annotation: 
       Subtype: Link
       Rect: 320, 156, 543, 163
      Annotation: 
       Subtype: Link
       Rect: 320, 146, 543, 153
      Annotation: 
       Subtype: Link
       Rect: 320, 135, 347, 142
      Annotation: 
       Subtype: Link
       Rect: 320, 125, 543, 132
      Annotation: 
       Subtype: Link
       Rect: 320, 114, 543, 121
      Annotation: 
       Subtype: Link
       Rect: 320, 104, 543, 111
      Annotation: 
       Subtype: Link
       Rect: 320, 93, 481, 100
      Annotation: 
       Subtype: Link
       Rect: 320, 82, 543, 89
      Annotation: 
       Subtype: Link
       Rect: 320, 72, 543, 79
      Annotation: 
       Subtype: Link
       Rect: 320, 61, 531, 68
    Page: 
     Label: 373
     Sequence: 6
     Annotations: 
      Annotation: 
       Subtype: Link
       Rect: 68, 720, 290, 727
      Annotation: 
       Subtype: Link
       Rect: 68, 709, 290, 716
      Annotation: 
       Subtype: Link
       Rect: 68, 699, 290, 706
      Annotation: 
       Subtype: Link
       Rect: 68, 688, 287, 695
      Annotation: 
       Subtype: Link
       Rect: 68, 678, 291, 685
      Annotation: 
       Subtype: Link
       Rect: 68, 667, 291, 674
      Annotation: 
       Subtype: Link
       Rect: 68, 657, 284, 664
      Annotation: 
       Subtype: Link
       Rect: 68, 646, 291, 653
      Annotation: 
       Subtype: Link
       Rect: 68, 635, 291, 642
      Annotation: 
       Subtype: Link
       Rect: 68, 625, 275, 632
      Annotation: 
       Subtype: Link
       Rect: 325, 720, 547, 727
      Annotation: 
       Subtype: Link
       Rect: 325, 709, 547, 716
      Annotation: 
       Subtype: Link
       Rect: 325, 699, 524, 706
      Annotation: 
       Subtype: Link
       Rect: 325, 688, 547, 695
      Annotation: 
       Subtype: Link
       Rect: 325, 678, 547, 685
      Annotation: 
       Subtype: Link
       Rect: 325, 667, 443, 674
      Annotation: 
       Subtype: Link
       Rect: 325, 657, 547, 664
      Annotation: 
       Subtype: Link
       Rect: 325, 646, 547, 653
      Annotation: 
       Subtype: Link
       Rect: 325, 635, 547, 642
      Annotation: 
       Subtype: Link
       Rect: 325, 625, 461, 632
  Checksum: 8d840b33
   Type: CRC32
  Checksum: 5a6fd9f85c90f941562b0f6d1bac50ed
   Type: MD5
  Checksum: 39ad270d735e2f1dcae864909e964c1d9e866785
   Type: SHA-1