cc7bba64e002e70dac8b6add116746fc 226430.pdf dacb852ef4bf98551e056cdea538869a2a4979bc 226430.pdf a508265e367c7b70d7acbdc6ea67cb79c8e65dbcdc1f3553c58ab34ea930dd05 226430.pdf Title: Skin microdialysis: methods, applications and future opportunities—an EAACI position paper Subject: Clinical and Translational Allergy, https://doi.org/10.1186/s13601-019-0262-y Keywords: Microdialysis,Cutaneous,Inflammation,Interstitial,Dermal Author: Katrine Y. Baumann Creator: Springer Producer: Acrobat Distiller 10.1.8 (Windows); modified using iText® 5.3.5 ©2000-2012 1T3XT BVBA (AGPL-version) CreationDate: Tue Apr 9 14:22:34 2019 CEST ModDate: Wed Apr 10 11:51:40 2019 CEST Tagged: no UserProperties: no Suspects: no Form: AcroForm JavaScript: no Pages: 13 Encrypted: no Page size: 595.276 x 790.866 pts Page rot: 0 File size: 1101510 bytes Optimized: no PDF version: 1.6 name type encoding emb sub uni object ID ------------------------------------ ----------------- ---------------- --- --- --- --------- MyriadPro-Light Type 1C Custom yes no yes 37 0 MyriadPro-It Type 1C Custom yes no yes 33 0 MyriadPro-Semibold Type 1C Custom yes no yes 34 0 MyriadPro-Bold Type 1C Custom yes no yes 32 0 WarnockPro-Regular Type 1C Custom yes no yes 35 0 MVXQAA+OpenSans Type 1C WinAnsi yes yes no 349 0 MyriadPro-Regular Type 1C Custom yes no yes 38 0 MyriadPro-Regular2 Type 1C Custom yes no no 36 0 XWKZYE+Arial-BoldMT Type 1C WinAnsi yes yes no 152 0 VUMERS+MTSY Type 1C Custom yes yes yes 190 0 RLAJCG+MyriadPro-LightIt Type 1C WinAnsi yes yes yes 276 0 IRSAWG+MyriadPro-Light-SC700 Type 1C WinAnsi yes yes yes 277 0 XZEUYE+STIXMath-Regular Type 1C WinAnsi yes yes yes 288 0 Jhove (Rel. 1.22.1, 2019-04-17) Date: 2021-07-02 02:39:44 CEST RepresentationInformation: 226430.pdf ReportingModule: PDF-hul, Rel. 1.12.1 (2019-04-17) LastModified: 2021-07-01 20:19:16 CEST Size: 1101510 Format: PDF Version: 1.6 Status: Well-Formed and valid SignatureMatches: PDF-hul MIMEtype: application/pdf PDFMetadata: Objects: 430 FreeObjects: 1 IncrementalUpdates: 0 DocumentCatalog: ViewerPreferences: HideToolbar: false HideMenubar: false HideWindowUI: false FitWindow: false CenterWindow: false DisplayDocTitle: false NonFullScreenPageMode: UseNone Direction: L2R ViewArea: CropBox ViewClip: CropBox PrintArea: CropBox PageClip: CropBox PageLayout: SinglePage PageMode: UseOutlines Language: EN Outlines: Item: Title: Skin microdialysis: methods, applications and future opportunities—an EAACI position paper Children: Item: Title: Abstract Item: Title: What is skin microdialysis? Item: Title: How SMD has helped us to understand skin inflammation and skin inflammatory disorders Children: Item: Title: What SMD taught us about cutaneous type 1 hypersensitivity reactions Item: Title: How SMD has helped our understanding of atopic dermatitis Item: Title: Insights from SMD studies on psoriasis Item: Title: Chronic urticaria: what did we learn from SMD studies? Item: Title: The use of SMD in studies of drug hypersensitivity and ultraviolet B (UVB)-induced skin responses Item: Title: The use of SMD to study neurogenic inflammation Item: Title: How SMD is used to study drug penetration and distribution Item: Title: SMD techniques and methodology Children: Item: Title: In vivo SMD Item: Title: Ex vivo SMD Item: Title: The strengths and limitations of SMD Item: Title: Ethical considerations in SMD studies Item: Title: Outlook: future applications of SMD Item: Title: Authors’ contributions Item: Title: References Info: Title: Skin microdialysis: methods, applications and future opportunities an EAACI position paper Author: Katrine Y. Baumann Subject: Clinical and Translational Allergy, https://doi.org/10.1186/s13601-019-0262-y Keywords: Microdialysis,Cutaneous,Inflammation,Interstitial,Dermal Creator: Springer Producer: Acrobat Distiller 10.1.8 (Windows); modified using iText® 5.3.5 ©2000-2012 1T3XT BVBA (AGPL-version) CreationDate: Tue Apr 09 14:52:34 CEST 2019 ModDate: Wed Apr 10 11:51:40 CEST 2019 ID: 0x3242b4fdf3e6c85a53d115e0a933c5e6, 0xc1cde72863a524ca4ecd07675cdcce30 Filters: FilterPipeline: FlateDecode FilterPipeline: DCTDecode Images: Image: NisoImageMetadata: FormatName: image/png ImageWidth: 39 ImageHeight: 39 BitsPerSample: 8 BitsPerSampleUnit: integer Filter: FlateDecode Intent: RelativeColorimetric Decode: 0, 255 Name: X Image: NisoImageMetadata: FormatName: image/png ImageWidth: 40 ImageHeight: 76 BitsPerSample: 8 BitsPerSampleUnit: integer Filter: FlateDecode Intent: RelativeColorimetric Decode: 0, 255 Name: X Image: NisoImageMetadata: FormatName: image/png ImageWidth: 81 ImageHeight: 84 BitsPerSample: 8 BitsPerSampleUnit: integer Filter: FlateDecode Intent: RelativeColorimetric Decode: 0, 255 Name: X Image: NisoImageMetadata: FormatName: image/png ImageWidth: 39 ImageHeight: 74 BitsPerSample: 8 BitsPerSampleUnit: integer Filter: FlateDecode Intent: RelativeColorimetric Decode: 0, 255 Name: X Image: NisoImageMetadata: FormatName: image/png ImageWidth: 39 ImageHeight: 76 BitsPerSample: 8 BitsPerSampleUnit: integer Filter: FlateDecode Intent: RelativeColorimetric Decode: 0, 255 Name: X Image: NisoImageMetadata: FormatName: image/jpg CompressionScheme: JPEG ImageWidth: 1775 ImageHeight: 556 ColorSpace: RGB BitsPerSample: 8 BitsPerSampleUnit: integer Intent: RelativeColorimetric Name: X Image: NisoImageMetadata: FormatName: image/jpg CompressionScheme: JPEG ImageWidth: 1186 ImageHeight: 2305 ColorSpace: RGB BitsPerSample: 8 BitsPerSampleUnit: integer Intent: RelativeColorimetric Name: X Image: NisoImageMetadata: FormatName: image/png ImageWidth: 1100 ImageHeight: 90 ColorSpace: black is zero BitsPerSample: 1 BitsPerSampleUnit: integer Filter: FlateDecode Intent: RelativeColorimetric Name: X Fonts: Type1: Font: BaseFont: MyriadPro-Bold FirstChar: 0 LastChar: 255 FontDescriptor: FontName: MyriadPro-Bold Flags: Nonsymbolic FontBBox: -163, -250, 1256, 989 FontFile3: true EncodingDictionary: BaseEncoding: WinAnsiEncoding Differences: true ToUnicode: true Font: BaseFont: XZEUYE+STIXMath-Regular FontSubset: true FirstChar: 32 LastChar: 174 FontDescriptor: FontName: XZEUYE+STIXMath-Regular Flags: Serif, Nonsymbolic FontBBox: -970, -524, 3238, 2566 FontFile3: true Encoding: WinAnsiEncoding ToUnicode: true Font: BaseFont: MyriadPro-It FirstChar: 0 LastChar: 255 FontDescriptor: FontName: MyriadPro-It Flags: Nonsymbolic, Italic FontBBox: -185, -250, 1090, 953 FontFile3: true EncodingDictionary: BaseEncoding: WinAnsiEncoding Differences: true ToUnicode: true Font: BaseFont: MyriadPro-Semibold FirstChar: 0 LastChar: 255 FontDescriptor: FontName: MyriadPro-Semibold Flags: Nonsymbolic FontBBox: -161, -250, 1198, 972 FontFile3: true EncodingDictionary: BaseEncoding: WinAnsiEncoding Differences: true ToUnicode: true Font: BaseFont: WarnockPro-Regular FirstChar: 0 LastChar: 255 FontDescriptor: FontName: WarnockPro-Regular Flags: Serif, Nonsymbolic FontBBox: -177, -533, 1474, 950 FontFile3: true EncodingDictionary: BaseEncoding: WinAnsiEncoding Differences: true ToUnicode: true Font: BaseFont: MyriadPro-Regular2 FirstChar: 0 LastChar: 255 FontDescriptor: FontName: MyriadPro-Regular2 Flags: Nonsymbolic FontBBox: -157, -250, 1126, 952 FontFile3: true EncodingDictionary: BaseEncoding: WinAnsiEncoding Differences: true Font: BaseFont: MyriadPro-Light FirstChar: 0 LastChar: 255 FontDescriptor: FontName: MyriadPro-Light Flags: Nonsymbolic FontBBox: -49, -250, 1046, 883 FontFile3: true EncodingDictionary: BaseEncoding: WinAnsiEncoding Differences: true ToUnicode: true Font: BaseFont: MyriadPro-Regular FirstChar: 0 LastChar: 255 FontDescriptor: FontName: MyriadPro-Regular Flags: Nonsymbolic FontBBox: -157, -250, 1126, 952 FontFile3: true EncodingDictionary: BaseEncoding: WinAnsiEncoding Differences: true ToUnicode: true Font: BaseFont: RLAJCG+MyriadPro-LightIt FontSubset: true FirstChar: 0 LastChar: 255 FontDescriptor: FontName: RLAJCG+MyriadPro-LightIt Flags: Nonsymbolic, Italic FontBBox: -121, -250, 1007, 863 FontFile3: true Encoding: WinAnsiEncoding ToUnicode: true Font: BaseFont: IRSAWG+MyriadPro-Light-SC700 FontSubset: true FirstChar: 0 LastChar: 255 FontDescriptor: FontName: IRSAWG+MyriadPro-Light-SC700 Flags: Nonsymbolic FontBBox: -49, -250, 1046, 883 FontFile3: true Encoding: WinAnsiEncoding ToUnicode: true Font: BaseFont: XWKZYE+Arial-BoldMT FontSubset: true FirstChar: 32 LastChar: 74 FontDescriptor: FontName: XWKZYE+Arial-BoldMT Flags: Nonsymbolic FontBBox: -628, -376, 2000, 1018 FontFile3: true Encoding: WinAnsiEncoding Font: BaseFont: MVXQAA+OpenSans FontSubset: true FirstChar: 32 LastChar: 121 FontDescriptor: FontName: MVXQAA+OpenSans Flags: Nonsymbolic FontBBox: -550, -271, 1204, 1048 FontFile3: true Encoding: WinAnsiEncoding Font: BaseFont: VUMERS+MTSY FontSubset: true FirstChar: 0 LastChar: 255 FontDescriptor: FontName: VUMERS+MTSY Flags: Symbolic FontBBox: 0, -954, 1043, 796 FontFile3: true EncodingDictionary: BaseEncoding: WinAnsiEncoding Differences: true ToUnicode: true XMP: 2019-04-09T17:52:34+05:30 Springer 2019-04-10T11:51:40+02:00 2019-04-10T11:51:40+02:00 Acrobat Distiller 10.1.8 (Windows); modified using iText® 5.3.5 ©2000-2012 1T3XT BVBA (AGPL-version) Microdialysis,Cutaneous,Inflammation,Interstitial,Dermal application/pdf https://doi.org/10.1186/s13601-019-0262-y BioMed Central Clinical and Translational Allergy, https://doi.org/10.1186/s13601-019-0262-y Microdialysis Cutaneous Inflammation Interstitial Dermal Skin microdialysis: methods, applications and future opportunities—an EAACI position paper Katrine Y. Baumann Martin K. Church Geraldine F. Clough Sven Roy Quist Martin Schmelz Per Stahl Skov Chris D. Anderson Line Kring Tannert Ana Maria Giménez-Arnau Stefan Frischbutter Jörg Scheffel Marcus Maurer 10.1186/s13601-019-0262-y 2010-04-23 true springer.com springerlink.com https://doi.org/10.1186/s13601-019-0262-y 10.1186/s13601-019-0262-y 2045-7022 journal Clinical and Translational Allergy The Author(s) 2010-04-23 true 10.1186/s13601-019-0262-y noindex springer.com springerlink.com CVoR uuid:8ea6bb5f-5367-4493-b6d5-4be10351c1b6 uuid:149a51d5-6c66-49a8-afa0-28fdf35e86dc default 1 converted uuid:e1d38d70-eb56-4669-aead-c03e9ab950c9 converted to PDF/A-2b pdfToolbox 2019-04-09T17:53:29+05:30 2 B http://ns.adobe.com/pdfx/1.3/ pdfx Adobe Document Info PDF eXtension Schema external Mirrors crossmark:MajorVersionDate CrossmarkMajorVersionDate Text external Mirrors crossmark:CrossmarkDomainExclusive CrossmarkDomainExclusive Text internal Mirrors crossmark:DOI doi Text external Mirrors crossmark:CrosMarkDomains CrossMarkDomains seq Text internal A name object indicating whether the document has been modified to include trapping information robots Text internal ID of PDF/X standard GTS_PDFXVersion Text internal Conformance level of PDF/X standard GTS_PDFXConformance Text internal Company creating the PDF Company Text internal Date when document was last modified SourceModified Text http://crossref.org/crossmark/1.0/ crossmark Crossmark Schema internal Usual same as prism:doi DOI Text external The date when a publication was publishe. MajorVersionDate Text internal CrossmarkDomainExclusive CrossmarkDomainExclusive Text internal CrossMarkDomains CrossMarkDomains seq Text http://prismstandard.org/namespaces/basic/2.0/ prism Prism Schema external This element provides the url for an article or unit of content. The attribute platform is optionally allowed for situations in which multiple URLs must be specified. PRISM recommends that a subset of the PCV platform values, namely “mobile” and “web”, be used in conjunction with this element. NOTE: PRISM recommends against the use of the #other value allowed in the PRISM Platform controlled vocabulary. In lieu of using #other please reach out to the PRISM group at prism-wg@yahoogroups.com to request addition of your term to the Platform Controlled Vocabulary. url URI external The Digital Object Identifier for the article. The DOI may also be used as the dc:identifier. If used as a dc:identifier, the URI form should be captured, and the bare identifier should also be captured using prism:doi. If an alternate unique identifier is used as the required dc:identifier, then the DOI should be specified as a bare identifier within prism:doi only. If the URL associated with a DOI is to be specified, then prism:url may be used in conjunction with prism:doi in order to provide the service endpoint (i.e. the URL). doi Text external ISSN for an electronic version of the issue in which the resource occurs. Permits publishers to include a second ISSN, identifying an electronic version of the issue in which the resource occurs (therefore e(lectronic)Issn. If used, prism:eIssn MUST contain the ISSN of the electronic version. issn Text internal Volume number volume Text internal Issue number number Text internal Starting page startingPage Text internal Ending page endingPage Text external The aggregation type specifies the unit of aggregation for a content collection. Comment PRISM recommends that the PRISM Aggregation Type Controlled Vocabulary be used to provide values for this element. Note: PRISM recommends against the use of the #other value currently allowed in this controlled vocabulary. In lieu of using #other please reach out to the PRISM group at info@prismstandard.org to request addition of your term to the Aggregation Type Controlled Vocabulary. aggregationType Text external Title of the magazine, or other publication, in which a resource was/will be published. Typically this will be used to provide the name of the magazine an article appeared in as metadata for the article, along with information such as the article title, the publisher, volume, number, and cover date. Note: Publication name can be used to differentiate between a print magazine and the online version if the names are different such as “magazine” and “magazine.com.” publicationName Text external Copyright copyright Text http://ns.adobe.com/pdf/1.3/ pdf Adobe PDF Schema internal A name object indicating whether the document has been modified to include trapping information Trapped Text http://ns.adobe.com/xap/1.0/mm/ xmpMM XMP Media Management Schema internal UUID based identifier for specific incarnation of a document InstanceID URI internal The common identifier for all versions and renditions of a document. DocumentID URI internal The common identifier for all versions and renditions of a document. OriginalDocumentID URI http://www.aiim.org/pdfa/ns/id/ pdfaid PDF/A ID Schema internal Part of PDF/A standard part Integer internal Amendment of PDF/A standard amd Text internal Conformance level of PDF/A standard conformance Text http://www.niso.org/schemas/jav/1.0/ jav NISO external Values for Journal Article Version are one of the following: AO = Author’s Original SMUR = Submitted Manuscript Under Review AM = Accepted Manuscript P = Proof VoR = Version of Record CVoR = Corrected Version of Record EVoR = Enhanced Version of Record journal_article_version Closed Choice of Text Pages: Page: Sequence: 1 Annotations: Annotation: Subtype: Link Rect: 182, 80, 307, 72 Flags: Print AppearanceDictionary: true Annotation: Subtype: Link Rect: 443, 64, 525, 56 Flags: Print AppearanceDictionary: true Annotation: Subtype: Link Rect: 180, 56, 247, 48 Flags: Print AppearanceDictionary: true Annotation: Subtype: Link Rect: 184, 269, 189, 257 Flags: Print AppearanceDictionary: true Destination: 3 Annotation: Subtype: Link Rect: 326, 222, 331, 210 Flags: Print AppearanceDictionary: true Destination: 253 Annotation: Subtype: Link Rect: 324, 162, 328, 150 Flags: Print AppearanceDictionary: true Destination: 253 Annotation: Subtype: Link Rect: 334, 162, 339, 150 Flags: Print AppearanceDictionary: true Destination: 253 Annotation: Subtype: Link Rect: 347, 138, 352, 126 Flags: Print AppearanceDictionary: true Destination: 253 Annotation: Subtype: Link Rect: 507, 683, 540, 650 Flags: Print AppearanceDictionary: true Thumb: true Page: Sequence: 2 Annotations: Annotation: Subtype: Link Rect: 236, 433, 241, 421 Flags: Print AppearanceDictionary: true Destination: 253 Annotation: Subtype: Link Rect: 247, 433, 251, 421 Flags: Print AppearanceDictionary: true Destination: 253 Annotation: Subtype: Link Rect: 80, 181, 85, 169 Flags: Print AppearanceDictionary: true Destination: 272 Annotation: Subtype: Link Rect: 91, 181, 101, 169 Flags: Print AppearanceDictionary: true Destination: 272 Annotation: Subtype: Link Rect: 224, 145, 234, 133 Flags: Print AppearanceDictionary: true Destination: 272 Annotation: Subtype: Link Rect: 161, 121, 171, 109 Flags: Print AppearanceDictionary: true Destination: 272 Annotation: Subtype: Link Rect: 523, 373, 533, 361 Flags: Print AppearanceDictionary: true Destination: 272 Annotation: Subtype: Link Rect: 372, 325, 382, 313 Flags: Print AppearanceDictionary: true Destination: 272 Annotation: Subtype: Link Rect: 473, 313, 483, 301 Flags: Print AppearanceDictionary: true Destination: 272 Annotation: Subtype: Link Rect: 389, 265, 398, 253 Flags: Print AppearanceDictionary: true Destination: 272 Annotation: Subtype: Link Rect: 391, 253, 396, 241 Flags: Print AppearanceDictionary: true Destination: 253 Thumb: true Page: Sequence: 3 Annotations: Annotation: Subtype: Link Rect: 274, 548, 284, 536 Flags: Print AppearanceDictionary: true Destination: 272 Annotation: Subtype: Link Rect: 128, 512, 138, 500 Flags: Print AppearanceDictionary: true Destination: 272 Annotation: Subtype: Link Rect: 144, 512, 154, 500 Flags: Print AppearanceDictionary: true Destination: 272 Annotation: Subtype: Link Rect: 117, 488, 127, 476 Flags: Print AppearanceDictionary: true Destination: 272 Annotation: Subtype: Link Rect: 134, 488, 144, 476 Flags: Print AppearanceDictionary: true Destination: 272 Annotation: Subtype: Link Rect: 221, 476, 231, 464 Flags: Print AppearanceDictionary: true Destination: 272 Annotation: Subtype: Link Rect: 203, 464, 213, 452 Flags: Print AppearanceDictionary: true Destination: 272 Annotation: Subtype: Link Rect: 89, 452, 99, 440 Flags: Print AppearanceDictionary: true Destination: 272 Annotation: Subtype: Link Rect: 164, 392, 174, 380 Flags: Print AppearanceDictionary: true Destination: 272 Annotation: Subtype: Link Rect: 180, 392, 190, 380 Flags: Print AppearanceDictionary: true Destination: 272 Annotation: Subtype: Link Rect: 82, 224, 92, 212 Flags: Print AppearanceDictionary: true Destination: 272 Annotation: Subtype: Link Rect: 160, 164, 170, 152 Flags: Print AppearanceDictionary: true Destination: 272 Annotation: Subtype: Link Rect: 120, 116, 130, 104 Flags: Print AppearanceDictionary: true Destination: 272 Annotation: Subtype: Link Rect: 351, 680, 361, 668 Flags: Print AppearanceDictionary: true Destination: 272 Annotation: Subtype: Link Rect: 307, 632, 317, 620 Flags: Print AppearanceDictionary: true Destination: 272 Annotation: Subtype: Link Rect: 360, 620, 370, 608 Flags: Print AppearanceDictionary: true Destination: 272 Annotation: Subtype: Link Rect: 416, 512, 425, 500 Flags: Print AppearanceDictionary: true Destination: 272 Annotation: Subtype: Link Rect: 368, 500, 378, 488 Flags: Print AppearanceDictionary: true Destination: 272 Annotation: Subtype: Link Rect: 375, 440, 385, 428 Flags: Print AppearanceDictionary: true Destination: 272 Annotation: Subtype: Link Rect: 497, 416, 507, 404 Flags: Print AppearanceDictionary: true Destination: 272 Annotation: Subtype: Link Rect: 342, 344, 352, 332 Flags: Print AppearanceDictionary: true Destination: 272 Annotation: Subtype: Link Rect: 440, 224, 450, 212 Flags: Print AppearanceDictionary: true Destination: 272 Thumb: true Page: Sequence: 4 Annotations: Annotation: Subtype: Link Rect: 205, 549, 215, 536 Flags: Print AppearanceDictionary: true Destination: 272 Annotation: Subtype: Link Rect: 278, 525, 288, 512 Flags: Print AppearanceDictionary: true Destination: 272 Annotation: Subtype: Link Rect: 56, 513, 66, 500 Flags: Print AppearanceDictionary: true Destination: 272 Annotation: Subtype: Link Rect: 72, 513, 82, 500 Flags: Print AppearanceDictionary: true Destination: 272 Annotation: Subtype: Link Rect: 146, 489, 156, 476 Flags: Print AppearanceDictionary: true Destination: 272 Annotation: Subtype: Link Rect: 141, 405, 151, 392 Flags: Print AppearanceDictionary: true Destination: 272 Annotation: Subtype: Link Rect: 493, 705, 503, 692 Flags: Print AppearanceDictionary: true Destination: 272 Annotation: Subtype: Link Rect: 426, 681, 435, 668 Flags: Print AppearanceDictionary: true Destination: 272 Annotation: Subtype: Link Rect: 478, 669, 488, 656 Flags: Print AppearanceDictionary: true Destination: 272 Annotation: Subtype: Link Rect: 388, 633, 398, 620 Flags: Print AppearanceDictionary: true Destination: 272 Annotation: Subtype: Link Rect: 404, 633, 414, 620 Flags: Print AppearanceDictionary: true Destination: 272 Annotation: Subtype: Link Rect: 525, 609, 535, 596 Flags: Print AppearanceDictionary: true Destination: 272 Annotation: Subtype: Link Rect: 435, 597, 445, 584 Flags: Print AppearanceDictionary: true Destination: 272 Annotation: Subtype: Link Rect: 450, 597, 460, 584 Flags: Print AppearanceDictionary: true Destination: 272 Annotation: Subtype: Link Rect: 307, 573, 317, 560 Flags: Print AppearanceDictionary: true Destination: 284 Annotation: Subtype: Link Rect: 333, 465, 343, 452 Flags: Print AppearanceDictionary: true Destination: 284 Annotation: Subtype: Link Rect: 514, 453, 519, 440 Flags: Print AppearanceDictionary: true Destination: 253 Annotation: Subtype: Link Rect: 526, 453, 536, 440 Flags: Print AppearanceDictionary: true Destination: 284 Annotation: Subtype: Link Rect: 304, 441, 314, 428 Flags: Print AppearanceDictionary: true Destination: 284 Annotation: Subtype: Link Rect: 356, 357, 361, 344 Flags: Print AppearanceDictionary: true Destination: 253 Annotation: Subtype: Link Rect: 367, 357, 377, 344 Flags: Print AppearanceDictionary: true Destination: 284 Annotation: Subtype: Link Rect: 383, 357, 393, 344 Flags: Print AppearanceDictionary: true Destination: 284 Annotation: Subtype: Link Rect: 307, 177, 317, 164 Flags: Print AppearanceDictionary: true Destination: 284 Annotation: Subtype: Link Rect: 322, 177, 332, 164 Flags: Print AppearanceDictionary: true Destination: 284 Thumb: true Page: Sequence: 5 Annotations: Annotation: Subtype: Link Rect: 177, 513, 186, 500 Flags: Print AppearanceDictionary: true Destination: 284 Annotation: Subtype: Link Rect: 123, 489, 128, 476 Flags: Print AppearanceDictionary: true Destination: 253 Annotation: Subtype: Link Rect: 136, 489, 146, 476 Flags: Print AppearanceDictionary: true Destination: 272 Annotation: Subtype: Link Rect: 153, 489, 163, 476 Flags: Print AppearanceDictionary: true Destination: 284 Annotation: Subtype: Link Rect: 169, 489, 179, 476 Flags: Print AppearanceDictionary: true Destination: 284 Annotation: Subtype: Link Rect: 211, 489, 216, 476 Flags: Print AppearanceDictionary: true Destination: 141 Annotation: Subtype: Link Rect: 103, 465, 112, 452 Flags: Print AppearanceDictionary: true Destination: 284 Annotation: Subtype: Link Rect: 272, 465, 281, 452 Flags: Print AppearanceDictionary: true Destination: 284 Annotation: Subtype: Link Rect: 59, 441, 69, 428 Flags: Print AppearanceDictionary: true Destination: 284 Annotation: Subtype: Link Rect: 147, 117, 157, 104 Flags: Print AppearanceDictionary: true Destination: 284 Annotation: Subtype: Link Rect: 162, 117, 172, 104 Flags: Print AppearanceDictionary: true Destination: 284 Annotation: Subtype: Link Rect: 166, 93, 176, 80 Flags: Print AppearanceDictionary: true Destination: 284 Annotation: Subtype: Link Rect: 332, 657, 337, 644 Flags: Print AppearanceDictionary: true Destination: 157 Annotation: Subtype: Link Rect: 448, 597, 458, 584 Flags: Print AppearanceDictionary: true Destination: 284 Annotation: Subtype: Link Rect: 463, 597, 473, 584 Flags: Print AppearanceDictionary: true Destination: 284 Annotation: Subtype: Link Rect: 389, 537, 394, 524 Flags: Print AppearanceDictionary: true Destination: 253 Annotation: Subtype: Link Rect: 435, 453, 446, 440 Flags: Print AppearanceDictionary: true Destination: 284 Annotation: Subtype: Link Rect: 448, 429, 458, 416 Flags: Print AppearanceDictionary: true Destination: 284 Annotation: Subtype: Link Rect: 470, 417, 480, 404 Flags: Print AppearanceDictionary: true Destination: 284 Annotation: Subtype: Link Rect: 486, 417, 497, 404 Flags: Print AppearanceDictionary: true Destination: 284 Annotation: Subtype: Link Rect: 397, 393, 407, 380 Flags: Print AppearanceDictionary: true Destination: 284 Annotation: Subtype: Link Rect: 395, 213, 400, 200 Flags: Print AppearanceDictionary: true Destination: 157 Annotation: Subtype: Link Rect: 346, 165, 351, 152 Flags: Print AppearanceDictionary: true Destination: 253 Thumb: true Page: Sequence: 6 Annotations: Annotation: Subtype: Link Rect: 111, 100, 115, 91 Flags: Print AppearanceDictionary: true Destination: 253 Annotation: Subtype: Link Rect: 131, 100, 135, 91 Flags: Print AppearanceDictionary: true Destination: 253 Thumb: true Page: Sequence: 7 Annotations: Annotation: Subtype: Link Rect: 111, 653, 120, 645 Flags: Print AppearanceDictionary: true Destination: 284 Annotation: Subtype: Link Rect: 111, 665, 120, 657 Flags: Print AppearanceDictionary: true Destination: 284 Annotation: Subtype: Link Rect: 159, 653, 168, 645 Flags: Print AppearanceDictionary: true Destination: 284 Annotation: Subtype: Link Rect: 189, 653, 198, 645 Flags: Print AppearanceDictionary: true Destination: 284 Annotation: Subtype: Link Rect: 189, 664, 198, 656 Flags: Print AppearanceDictionary: true Destination: 284 Annotation: Subtype: Link Rect: 189, 675, 198, 667 Flags: Print AppearanceDictionary: true Destination: 284 Annotation: Subtype: Link Rect: 189, 687, 198, 679 Flags: Print AppearanceDictionary: true Destination: 292 Annotation: Subtype: Link Rect: 248, 653, 257, 646 Flags: Print AppearanceDictionary: true Destination: 284 Annotation: Subtype: Link Rect: 248, 664, 257, 657 Flags: Print AppearanceDictionary: true Destination: 284 Annotation: Subtype: Link Rect: 248, 675, 257, 668 Flags: Print AppearanceDictionary: true Destination: 284 Annotation: Subtype: Link Rect: 248, 686, 257, 679 Flags: Print AppearanceDictionary: true Destination: 284 Annotation: Subtype: Link Rect: 248, 697, 257, 689 Flags: Print AppearanceDictionary: true Destination: 292 Annotation: Subtype: Link Rect: 287, 653, 296, 646 Flags: Print AppearanceDictionary: true Destination: 284 Annotation: Subtype: Link Rect: 287, 664, 296, 657 Flags: Print AppearanceDictionary: true Destination: 284 Annotation: Subtype: Link Rect: 317, 653, 326, 646 Flags: Print AppearanceDictionary: true Destination: 292 Annotation: Subtype: Link Rect: 317, 665, 326, 657 Flags: Print AppearanceDictionary: true Destination: 292 Annotation: Subtype: Link Rect: 369, 653, 378, 646 Flags: Print AppearanceDictionary: true Destination: 284 Annotation: Subtype: Link Rect: 369, 664, 378, 657 Flags: Print AppearanceDictionary: true Destination: 292 Annotation: Subtype: Link Rect: 369, 675, 378, 668 Flags: Print AppearanceDictionary: true Destination: 292 Annotation: Subtype: Link Rect: 453, 653, 462, 646 Flags: Print AppearanceDictionary: true Destination: 284 Annotation: Subtype: Link Rect: 453, 664, 462, 657 Flags: Print AppearanceDictionary: true Destination: 292 Annotation: Subtype: Link Rect: 453, 675, 462, 668 Flags: Print AppearanceDictionary: true Destination: 292 Annotation: Subtype: Link Rect: 492, 653, 501, 646 Flags: Print AppearanceDictionary: true Destination: 284 Annotation: Subtype: Link Rect: 492, 664, 501, 657 Flags: Print AppearanceDictionary: true Destination: 292 Annotation: Subtype: Link Rect: 492, 675, 501, 668 Flags: Print AppearanceDictionary: true Destination: 292 Thumb: true Page: Sequence: 8 Annotations: Annotation: Subtype: Link Rect: 89, 653, 98, 646 Flags: Print AppearanceDictionary: true Destination: 284 Annotation: Subtype: Link Rect: 89, 664, 98, 657 Flags: Print AppearanceDictionary: true Destination: 284 Annotation: Subtype: Link Rect: 89, 675, 98, 668 Flags: Print AppearanceDictionary: true Destination: 292 Annotation: Subtype: Link Rect: 89, 686, 98, 679 Flags: Print AppearanceDictionary: true Destination: 292 Annotation: Subtype: Link Rect: 89, 697, 98, 689 Flags: Print AppearanceDictionary: true Destination: 292 Annotation: Subtype: Link Rect: 98, 661, 107, 650 Flags: Print AppearanceDictionary: true Destination: 292 Annotation: Subtype: Link Rect: 98, 677, 107, 665 Flags: Print AppearanceDictionary: true Destination: 292 Annotation: Subtype: Link Rect: 137, 653, 146, 646 Flags: Print AppearanceDictionary: true Destination: 284 Annotation: Subtype: Link Rect: 137, 664, 146, 657 Flags: Print AppearanceDictionary: true Destination: 292 Annotation: Subtype: Link Rect: 137, 679, 146, 668 Flags: Print AppearanceDictionary: true Destination: 292 Annotation: Subtype: Link Rect: 196, 654, 205, 647 Flags: Print AppearanceDictionary: true Destination: 284 Annotation: Subtype: Link Rect: 196, 665, 205, 657 Flags: Print AppearanceDictionary: true Destination: 284 Annotation: Subtype: Link Rect: 196, 676, 205, 668 Flags: Print AppearanceDictionary: true Destination: 292 Annotation: Subtype: Link Rect: 196, 691, 205, 679 Flags: Print AppearanceDictionary: true Destination: 292 Annotation: Subtype: Link Rect: 239, 650, 248, 647 Flags: Print AppearanceDictionary: true Destination: 253 Annotation: Subtype: Link Rect: 239, 661, 248, 654 Flags: Print AppearanceDictionary: true Destination: 284 Annotation: Subtype: Link Rect: 239, 672, 248, 665 Flags: Print AppearanceDictionary: true Destination: 284 Annotation: Subtype: Link Rect: 239, 683, 248, 675 Flags: Print AppearanceDictionary: true Destination: 284 Annotation: Subtype: Link Rect: 239, 694, 248, 686 Flags: Print AppearanceDictionary: true Destination: 292 Annotation: Subtype: Link Rect: 248, 662, 257, 650 Flags: Print AppearanceDictionary: true Destination: 292 Annotation: Subtype: Link Rect: 248, 677, 257, 665 Flags: Print AppearanceDictionary: true Destination: 292 Annotation: Subtype: Link Rect: 287, 654, 296, 647 Flags: Print AppearanceDictionary: true Destination: 284 Annotation: Subtype: Link Rect: 287, 665, 296, 657 Flags: Print AppearanceDictionary: true Destination: 292 Annotation: Subtype: Link Rect: 287, 680, 296, 668 Flags: Print AppearanceDictionary: true Destination: 292 Annotation: Subtype: Link Rect: 335, 650, 344, 647 Flags: Print AppearanceDictionary: true Destination: 253 Annotation: Subtype: Link Rect: 335, 661, 344, 654 Flags: Print AppearanceDictionary: true Destination: 272 Annotation: Subtype: Link Rect: 335, 672, 344, 665 Flags: Print AppearanceDictionary: true Destination: 284 Annotation: Subtype: Link Rect: 335, 683, 344, 675 Flags: Print AppearanceDictionary: true Destination: 284 Annotation: Subtype: Link Rect: 335, 695, 344, 687 Flags: Print AppearanceDictionary: true Destination: 284 Annotation: Subtype: Link Rect: 344, 658, 353, 650 Flags: Print AppearanceDictionary: true Destination: 284 Annotation: Subtype: Link Rect: 344, 669, 353, 661 Flags: Print AppearanceDictionary: true Destination: 292 Annotation: Subtype: Link Rect: 344, 684, 353, 672 Flags: Print AppearanceDictionary: true Destination: 292 Annotation: Subtype: Link Rect: 344, 699, 353, 687 Flags: Print AppearanceDictionary: true Destination: 292 Annotation: Subtype: Link Rect: 374, 654, 383, 647 Flags: Print AppearanceDictionary: true Destination: 284 Annotation: Subtype: Link Rect: 374, 665, 383, 657 Flags: Print AppearanceDictionary: true Destination: 284 Annotation: Subtype: Link Rect: 374, 680, 383, 668 Flags: Print AppearanceDictionary: true Destination: 292 Annotation: Subtype: Link Rect: 374, 695, 383, 683 Flags: Print AppearanceDictionary: true Destination: 292 Annotation: Subtype: Link Rect: 383, 662, 392, 650 Flags: Print AppearanceDictionary: true Destination: 292 Annotation: Subtype: Link Rect: 422, 654, 431, 647 Flags: Print AppearanceDictionary: true Destination: 284 Annotation: Subtype: Link Rect: 422, 665, 431, 657 Flags: Print AppearanceDictionary: true Destination: 284 Annotation: Subtype: Link Rect: 422, 676, 431, 668 Flags: Print AppearanceDictionary: true Destination: 292 Thumb: true Page: Sequence: 9 Annotations: Annotation: Subtype: Link Rect: 230, 369, 235, 357 Flags: Print AppearanceDictionary: true Destination: 243 Annotation: Subtype: Link Rect: 177, 285, 187, 273 Flags: Print AppearanceDictionary: true Destination: 284 Annotation: Subtype: Link Rect: 128, 177, 138, 165 Flags: Print AppearanceDictionary: true Destination: 284 Annotation: Subtype: Link Rect: 308, 105, 318, 93 Flags: Print AppearanceDictionary: true Destination: 284 Thumb: true Page: Sequence: 10 Annotations: Annotation: Subtype: Link Rect: 279, 621, 284, 608 Flags: Print AppearanceDictionary: true Destination: 253 Annotation: Subtype: Link Rect: 60, 549, 70, 536 Flags: Print AppearanceDictionary: true Destination: 284 Annotation: Subtype: Link Rect: 77, 549, 87, 536 Flags: Print AppearanceDictionary: true Destination: 284 Annotation: Subtype: Link Rect: 146, 369, 157, 356 Flags: Print AppearanceDictionary: true Destination: 284 Annotation: Subtype: Link Rect: 161, 369, 172, 356 Flags: Print AppearanceDictionary: true Destination: 284 Annotation: Subtype: Link Rect: 62, 258, 115, 248 Flags: Print AppearanceDictionary: true Annotation: Subtype: Link Rect: 62, 227, 115, 217 Flags: Print AppearanceDictionary: true Thumb: true Page: Sequence: 11 Thumb: true Page: Sequence: 12 Thumb: true Page: Sequence: 13 Thumb: true Checksum: 7e0c9538 Type: CRC32 Checksum: cc7bba64e002e70dac8b6add116746fc Type: MD5 Checksum: dacb852ef4bf98551e056cdea538869a2a4979bc Type: SHA-1