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Title:          Age-related metabolic changes limit efficacy of deoxynucleoside-based therapy in thymidine kinase 2-deficient mice
Subject:        EBioMedicine, 46 (2019) 342-355. doi:10.1016/j.ebiom.2019.07.042
Keywords:       TK2;  Deoxynucleoside therapy;  mtDNA depletion;  Encephalomyopathy;  Thymidine;  Deoxycytidine
Author:         Cora Blázquez-Bermejo
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      Title: Age-„related metabolic changes limit efficacy of deoxynucleoside-„based therapy in thymidine kinase 2-„deficient mice
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        Title: 1. Introduction
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        Title: Evidence before this study
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        Title: Added value of this study
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        Title: Implications of all the available evidence
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        Title: 2. Materials and methods
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          Title: 2.1. Ethics statement
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          Title: 2.2. Mice housing, treatment administration, tissue collection and endpoints
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          Title: 2.3. mtDNA copy number determination
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          Title: 2.4. Determination of metabolite levels in mouse plasma and tissues
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          Title: 2.5. RNA isolation and analysis of expression
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          Title: 3.2. dThd+dCtd administration rescues mtDNA copy number in skeletal muscle only at early ages
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          Title: 3.3. dThd and dCtd bioavailability markedly decreases during mouse development
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          Title: 3.4. Expression and activity of key metabolic enzymes undergo marked ontogenetic changes
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          Title: 3.5. dThd alone is responsible for the therapeutic effect
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   Type: MD5
  Checksum: d92cd6e614c81d427e492d459c0b0c69405d1ad5
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