7896a16c9117562108ea2b2f5a816091  226617.pdf
6a27a1796c9954d333980fdc80cde5c880954bb9  226617.pdf
73b30d881530c50cb8810d2faf5622dc03ee25ced37c59e70d018bfc3c7da4e6  226617.pdf

Title:          Non-invasive vagus nerve stimulation (nVNS) for the preventive treatment of episodic migraine: The multicentre, double-blind, randomised, sham-controlled PREMIUM trial
Subject:        Cephalalgia 2019.39:1475-1487
Keywords:       Neuromodulation,preventive therapy,RCT,migraine prophylaxis,non-pharmacologic treatment,vagal activation
Author:         Hans-Christoph Diener, Peter J Goadsby, Messoud Ashina, Mohammad Al-Mahdi Al-Karagholi, Alexandra Sinclair, Dimos Mitsikostas, Delphine Magis, Patricia Pozo-Rosich, Pablo Irimia Sieira, Miguel JA Làinez, Charly Gaul, Nicholas Silver, Jan Hoffmann, Juana Marin, Eric Liebler, and Michel D Ferrari
Creator:        3B2 Total Publishing System 8.07r/W
Producer:       Adobe LiveCycle PDF Generator; modified using iText 4.2.0 by 1T3XT
CreationDate:   Thu Oct 10 12:28:38 2019 CEST
ModDate:        Fri Feb 18 11:14:14 2022 CET
Tagged:         no
UserProperties: no
Suspects:       no
Form:           none
JavaScript:     no
Pages:          13
Encrypted:      no
Page size:      595.276 x 793.701 pts
Page rot:       0
File size:      843395 bytes
Optimized:      yes
PDF version:    1.6


name                                 type              encoding         emb sub uni object ID
------------------------------------ ----------------- ---------------- --- --- --- ---------
IKFNIK+AdvP7D0C                      Type 1C           WinAnsi          yes yes no     164  0
IKFNIL+AdvP7D0F                      Type 1C           WinAnsi          yes yes no     166  0
IKFODI+AdvP7D09                      Type 1C           WinAnsi          yes yes no     168  0
IKFODJ+AdvT001                       Type 1C           Custom           yes yes no     171  0
IKFODK+AdvMT_SY                      Type 1C           Custom           yes yes yes    174  0
IKFOEL+AdvP42A1B7                    Type 1C           WinAnsi          yes yes no     176  0
IKFOJK+AdvTimes                      Type 1C           Custom           yes yes yes     99  0
IKFOKK+AdvMT_MI                      Type 1C           Custom           yes yes yes     97  0
IKFOLL+AdvP49A5A                     Type 1C           Custom           yes yes yes    100  0
IKFOPK+AdvTimes-i                    Type 1C           Custom           yes yes yes    101  0
IKFPDK+Helvetica                     Type 1C           WinAnsi          yes yes no     106  0
IKFPDL+Helvetica-Oblique             Type 1C           WinAnsi          yes yes no     105  0
Symbol                               Type 1C           Custom           yes no  yes    113  0
IKFPJK+Arial                         Type 1C           WinAnsi          yes yes no     109  0
IKGAHG+AdvPi1                        Type 1C           WinAnsi          yes yes no     114  0


Jhove (Rel. 1.22.1, 2019-04-17)
 Date: 2022-02-19 02:33:50 CET
 RepresentationInformation: 226617.pdf
  ReportingModule: PDF-hul, Rel. 1.12.1 (2019-04-17)
  LastModified: 2022-02-18 11:42:19 CET
  Size: 843395
  Format: PDF
  Version: 1.6
  Status: Well-Formed and valid
  SignatureMatches:
   PDF-hul
  MIMEtype: application/pdf
  Profile: Linearized PDF
  PDFMetadata: 
   Objects: 0
   FreeObjects: 1
   IncrementalUpdates: 0
   DocumentCatalog: 
    PageLayout: SinglePage
    PageMode: UseNone
   Filters: 
    FilterPipeline: FlateDecode
    FilterPipeline: DCTDecode
   Images: 
    Image: 
     NisoImageMetadata: 
      FormatName: image/png
      ImageWidth: 228
      ImageHeight: 45
      ColorSpace: RGB
      BitsPerSample: 8
      BitsPerSampleUnit: integer
     Filter: FlateDecode
    Image: 
     NisoImageMetadata: 
      FormatName: image/png
      ImageWidth: 228
      ImageHeight: 45
      ColorSpace: black is zero
      BitsPerSample: 8
      BitsPerSampleUnit: integer
     Filter: FlateDecode
    Image: 
     NisoImageMetadata: 
      FormatName: image/jpg
      CompressionScheme: JPEG
      ImageWidth: 445
      ImageHeight: 272
      ColorSpace: RGB
      BitsPerSample: 8
      BitsPerSampleUnit: integer
   Fonts: 
    Type1: 
     Font: 
      BaseFont: IKFOKK+AdvMT_MI
      FontSubset: true
      FirstChar: 60
      LastChar: 60
      FontDescriptor: 
       FontName: IKFOKK+AdvMT_MI
       Flags: Serif, Symbolic
       FontBBox: -145, -208, 1072, 791
       FontFile3: true
      EncodingDictionary: 
       Differences: true
      ToUnicode: true
     Font: 
      BaseFont: IKFOJK+AdvTimes
      FontSubset: true
      FirstChar: 2
      LastChar: 154
      FontDescriptor: 
       FontName: IKFOJK+AdvTimes
       Flags: Serif, Symbolic
       FontBBox: -217, -212, 1005, 766
       FontFile3: true
      EncodingDictionary: 
       Differences: true
      ToUnicode: true
     Font: 
      BaseFont: IKFNIK+AdvP7D0C
      FontSubset: true
      FirstChar: 40
      LastChar: 121
      FontDescriptor: 
       FontName: IKFNIK+AdvP7D0C
       Flags: Nonsymbolic
       FontBBox: -197, -218, 1000, 729
       FontFile3: true
      Encoding: WinAnsiEncoding
     Font: 
      BaseFont: IKFOLL+AdvP49A5A
      FontSubset: true
      FirstChar: 88
      LastChar: 108
      FontDescriptor: 
       FontName: IKFOLL+AdvP49A5A
       Flags: Serif, Symbolic
       FontBBox: -31, -218, 1000, 864
       FontFile3: true
      EncodingDictionary: 
       Differences: true
      ToUnicode: true
     Font: 
      BaseFont: IKFOPK+AdvTimes-i
      FontSubset: true
      FirstChar: 38
      LastChar: 144
      FontDescriptor: 
       FontName: IKFOPK+AdvTimes-i
       Flags: Serif, Symbolic
       FontBBox: -253, -211, 1078, 766
       FontFile3: true
      EncodingDictionary: 
       Differences: true
      ToUnicode: true
     Font: 
      BaseFont: IKFNIL+AdvP7D0F
      FontSubset: true
      FirstChar: 40
      LastChar: 122
      FontDescriptor: 
       FontName: IKFNIL+AdvP7D0F
       Flags: Nonsymbolic
       FontBBox: -166, -218, 1166, 718
       FontFile3: true
      Encoding: WinAnsiEncoding
     Font: 
      BaseFont: IKFODI+AdvP7D09
      FontSubset: true
      FirstChar: 32
      LastChar: 168
      FontDescriptor: 
       FontName: IKFODI+AdvP7D09
       Flags: Nonsymbolic
       FontBBox: -156, -218, 1041, 729
       FontFile3: true
      Encoding: WinAnsiEncoding
     Font: 
      BaseFont: IKFPDL+Helvetica-Oblique
      FontSubset: true
      FirstChar: 61
      LastChar: 110
      FontDescriptor: 
       FontName: IKFPDL+Helvetica-Oblique
       Flags: Nonsymbolic, Italic
       FontBBox: -170, -225, 1116, 931
       FontFile3: true
      Encoding: WinAnsiEncoding
     Font: 
      BaseFont: IKFPDK+Helvetica
      FontSubset: true
      FirstChar: 32
      LastChar: 177
      FontDescriptor: 
       FontName: IKFPDK+Helvetica
       Flags: Nonsymbolic
       FontBBox: -166, -225, 1000, 931
       FontFile3: true
      Encoding: WinAnsiEncoding
     Font: 
      BaseFont: IKFODJ+AdvT001
      FontSubset: true
      FirstChar: 2
      LastChar: 2
      FontDescriptor: 
       FontName: IKFODJ+AdvT001
       Flags: Symbolic
       FontBBox: -197, -260, 1000, 937
       FontFile3: true
      EncodingDictionary: 
       Differences: true
     Font: 
      BaseFont: IKFPJK+Arial
      FontSubset: true
      FirstChar: 32
      LastChar: 116
      FontDescriptor: 
       FontName: IKFPJK+Arial
       Flags: Nonsymbolic
       FontBBox: -222, -250, 1006, 922
       FontFile3: true
      Encoding: WinAnsiEncoding
     Font: 
      BaseFont: IKFODK+AdvMT_SY
      FontSubset: true
      FirstChar: 2
      LastChar: 188
      FontDescriptor: 
       FontName: IKFODK+AdvMT_SY
       Flags: Serif, Symbolic
       FontBBox: -20, -947, 1114, 770
       FontFile3: true
      EncodingDictionary: 
       Differences: true
      ToUnicode: true
     Font: 
      BaseFont: IKFOEL+AdvP42A1B7
      FontSubset: true
      FirstChar: 33
      LastChar: 33
      FontDescriptor: 
       FontName: IKFOEL+AdvP42A1B7
       Flags: Serif, Nonsymbolic
       FontBBox: -62, -343, 1239, 729
       FontFile3: true
      Encoding: WinAnsiEncoding
     Font: 
      BaseFont: Symbol
      FirstChar: 0
      LastChar: 255
      FontDescriptor: 
       FontName: Symbol
       Flags: Symbolic
       FontBBox: -180, -293, 1090, 1010
       FontFile3: true
      EncodingDictionary: 
       Differences: true
      ToUnicode: true
     Font: 
      BaseFont: IKGAHG+AdvPi1
      FontSubset: true
      FirstChar: 46
      LastChar: 46
      FontDescriptor: 
       FontName: IKGAHG+AdvPi1
       Flags: Serif, Nonsymbolic
       FontBBox: 13, -323, 958, 824
       FontFile3: true
      Encoding: WinAnsiEncoding
   XMP: <x:xmpmeta xmlns:x="adobe:ns:meta/" x:xmptk="Adobe XMP Core 5.6-c015 91.163280, 2018/06/22-11:31:03        ">
   <rdf:RDF xmlns:rdf="http://www.w3.org/1999/02/22-rdf-syntax-ns#">
      <rdf:Description rdf:about=""
            xmlns:dc="http://purl.org/dc/elements/1.1/"
            xmlns:prism="http://prismstandard.org/namespaces/basic/2.1/"
            xmlns:crossmark="http://crossref.org/crossmark/1.0/"
            xmlns:pdfx="http://ns.adobe.com/pdfx/1.3/"
            xmlns:xmp="http://ns.adobe.com/xap/1.0/"
            xmlns:pdf="http://ns.adobe.com/pdf/1.3/"
            xmlns:xmpMM="http://ns.adobe.com/xap/1.0/mm/">
         <dc:format>application/pdf</dc:format>
         <dc:identifier>doi:10.1177/0333102419876920</dc:identifier>
         <dc:creator>
            <rdf:Seq>
               <rdf:li>Hans-Christoph Diener, Peter J Goadsby, Messoud Ashina, Mohammad Al-Mahdi Al-Karagholi, Alexandra Sinclair, Dimos Mitsikostas, Delphine Magis, Patricia Pozo-Rosich, Pablo Irimia Sieira, Miguel JA Làinez, Charly Gaul, Nicholas Silver, Jan Hoffmann, Juana Marin, Eric Liebler, and Michel D Ferrari</rdf:li>
            </rdf:Seq>
         </dc:creator>
         <dc:description>
            <rdf:Alt>
               <rdf:li xml:lang="x-default">Cephalalgia 2019.39:1475-1487</rdf:li>
            </rdf:Alt>
         </dc:description>
         <dc:title>
            <rdf:Alt>
               <rdf:li xml:lang="x-default">Non-invasive vagus nerve stimulation (nVNS) for the preventive treatment of episodic migraine: The multicentre, double-blind, randomised, sham-controlled PREMIUM trial</rdf:li>
            </rdf:Alt>
         </dc:title>
         <prism:doi>10.1177/0333102419876920</prism:doi>
         <prism:url>https://doi.org/10.1177/0333102419876920</prism:url>
         <crossmark:MajorVersionDate>2019-09-15</crossmark:MajorVersionDate>
         <crossmark:CrossmarkDomainExclusive>true</crossmark:CrossmarkDomainExclusive>
         <crossmark:DOI>10.1177/0333102419876920</crossmark:DOI>
         <crossmark:CrossMarkDomains>
            <rdf:Seq>
               <rdf:li>journals.sagepub.com</rdf:li>
            </rdf:Seq>
         </crossmark:CrossMarkDomains>
         <pdfx:CrossmarkDomainExclusive>true</pdfx:CrossmarkDomainExclusive>
         <pdfx:CrossmarkMajorVersionDate>2019-09-15</pdfx:CrossmarkMajorVersionDate>
         <pdfx:doi>10.1177/0333102419876920</pdfx:doi>
         <pdfx:CrossMarkDomains>
            <rdf:Seq>
               <rdf:li>journals.sagepub.com</rdf:li>
            </rdf:Seq>
         </pdfx:CrossMarkDomains>
         <xmp:CreateDate>2019-10-10T15:58:38+05:30</xmp:CreateDate>
         <xmp:CreatorTool>3B2 Total Publishing System 8.07r/W</xmp:CreatorTool>
         <xmp:ModifyDate>2022-02-18T11:14:14+01:00</xmp:ModifyDate>
         <xmp:MetadataDate>2022-02-18T11:14:14+01:00</xmp:MetadataDate>
         <pdf:Keywords>Neuromodulation,preventive therapy,RCT,migraine prophylaxis,non-pharmacologic treatment,vagal activation</pdf:Keywords>
         <pdf:Producer>Adobe LiveCycle PDF Generator; modified using iText 4.2.0 by 1T3XT</pdf:Producer>
         <xmpMM:DocumentID>uuid:bac76f00-2b77-45da-b583-668b905ce256</xmpMM:DocumentID>
         <xmpMM:InstanceID>uuid:1032fb26-d543-4f64-989b-3acf3c459807</xmpMM:InstanceID>
      </rdf:Description>
   </rdf:RDF>
</x:xmpmeta>
   Pages: 
    Page: 
     Label: 1
     Annotations: 
      Annotation: 
       Subtype: Link
       Rect: 300, 560, 309, 568
      Annotation: 
       Subtype: Link
       Rect: 265, 546, 273, 554
      Annotation: 
       Subtype: Link
       Rect: 268, 532, 277, 540
      Annotation: 
       Subtype: Link
       Rect: 255, 504, 263, 512
      Annotation: 
       Subtype: Link
       Rect: 350, 248, 544, 258
      Annotation: 
       Subtype: Link
       Rect: 433, 662, 530, 669
      Annotation: 
       Subtype: Link
       Rect: 450, 653, 530, 660
      Annotation: 
       Subtype: Link
       Rect: 433, 644, 523, 651
      Annotation: 
       Subtype: Link
       Rect: 25, 788, 89, 775
    Page: 
     Label: 2
    Page: 
     Label: 3
    Page: 
     Label: 4
    Page: 
     Label: 5
    Page: 
     Label: 6
    Page: 
     Label: 7
    Page: 
     Label: 8
    Page: 
     Label: 9
    Page: 
     Label: 10
    Page: 
     Label: 11
    Page: 
     Label: 12
     Annotations: 
      Annotation: 
       Subtype: Link
       Rect: 116, 385, 126, 394
      Annotation: 
       Subtype: Link
       Rect: 195, 374, 205, 383
      Annotation: 
       Subtype: Link
       Rect: 114, 352, 123, 361
      Annotation: 
       Subtype: Link
       Rect: 108, 341, 118, 350
    Page: 
     Label: 13
  Checksum: 3875dcd1
   Type: CRC32
  Checksum: 7896a16c9117562108ea2b2f5a816091
   Type: MD5
  Checksum: 6a27a1796c9954d333980fdc80cde5c880954bb9
   Type: SHA-1