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Title:          Cell necrosis, intrinsic apoptosis and senescence contribute to the progression of exencephaly to anencephaly in a mice model of congenital chranioschisis
Subject:        Cell Death and Disease, doi:10.1038/s41419-019-1913-6
Keywords:       
Author:         Marc Oria
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      Title: Cell necrosis, intrinsic apoptosis and senescence contribute to the progression of exencephaly to anencephaly in a mice model 漀昀 挀漀渀最攀渀椀琀愀氀 挀栀爀愀渀椀漀猀挀栀椀猀椀猩㸾൥湤潢樍㌹㌠〠潢樍㰼⽃嬰⸰‰⸰‰⸰崯䍯畮琠〯䑥獴⣾＀䄀ㄩ⽆‰⽎數琠㐰〠〠刯偡牥湴″㤲‰⁒⽔楴汥⣾＀䤀渀琀爀漀搀甀挀琀椀漀温㸾൥湤潢樍㌹㐠〠潢樍㰼⽃嬰⸰‰⸰‰⸰崯䍯畮琠〯䑥獴⣾＀䴀ㄩ⽆‰⽐慲敮琠㌹㈠〠刯偲敶″㤵‰⁒⽔楴汥⣾＀䄀䌀䬀一伀圀䰀䔀䐀䜀䴀䔀一吀匩㸾൥湤潢樍㌹㔠〠潢樍㰼⽃嬰⸰‰⸰‰⸰崯䍯畮琠〯䑥獴⣾＀䄀㔩⽆‰⽎數琠㌹㐠〠刯偡牥湴″㤲‰⁒⽐牥瘠㌹㘠〠刯呩瑬攨Conclusion
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        Title: Introduction
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        Title: Material and methods
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          Title: Animal preparation and valproic acid (VPA) exposure
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          Title: Tissue samples: brain, spinal cord
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          Title: RNA extraction and RT-qPCR
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          Title: Protein extraction
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            Title: Western blot
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          Title: Histological analysis
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          Title: Immunofluorescence
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          Title: Neurotracer assay
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         Item: 
          Title: TUNEL assay
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          Title: Flow cytometry with Annexin V (AV) and Propidium Iodide (PI)
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          Title: Statistical analysis
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          Title: Loss of layer organization in VPA-induced exencephalic fetuses
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          Title: Reduction of neuronal and glial protein expression in exencephalic fetuses
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          Title: Detection of necrosis, apoptosis and senescence in VPA-induced exencephalic fetuses
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          Title: Overexpression of intrinsic apoptosis pathway in the brain and spinal cord of VPA-induced exencephalic fetuses
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          Title: Material and methods
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          Title: Conclusion
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          Title: ACKNOWLEDGMENTS
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