Intrinsic pathway                                          Pore forming     T22-PUMA-GFP-H6
(mitochondrial pathway)                                          proteins
 UV irradiation, growth factor                                  (BH1-BH4):
 removal, oxydative stress….         Activator BH3s:                BAK
                                                                                T22-BAXPORO-GFP-H6
                                          PUMA                      BAX
                                           BIM                   Inactivated
     Sensitizers BH3s:                     BID
           BAD                                                         Conformational
          NOXA                                                            change
            BIK                                                Pore forming
           HRK                                                   proteins
                                     Anti-apoptotic:
                                                                (BH1-BH4):
                                       (BH1-BH4)
                                                                   BAK
                                          BCL-2
                                                                   BAX
                                         BCL-xL                   Activated
   T22-PUMA-GFP-H6                       BCL-W
                                         MCL-1
      T22-BAK-GFP-H6                                   Cyt C
    Extrinsic pathway                                                MOMP
(death receptor pathway)                  Apaf-1
         FASL, TRAIL….
                                              Caspase-9
                         Caspase-8                 Caspase-3                   APOPTOSIS