4241b529b2a352f880475b9dc0448bdc  236797.pdf
c1bea488ecc6d4e6ab60c35a0bbb0d8c8a6c00e2  236797.pdf
3b99c062d1e41e95f0bf878aae1aa2d5587b98a77c8a39858333d8db11aafcf7  236797.pdf

Title:          Ixazomib as Postinduction Maintenance for Patients With Newly Diagnosed Multiple Myeloma Not Undergoing Autologous Stem Cell Transplantation: The Phase III TOURMALINE-MM4 Trial
Subject:        JCO 2020.38:4030-4041
Author:         Meletios A. Dimopoulos, Ivan Špička, Hang Quach, Albert Oriol, Roman Hájek, Mamta Garg, Meral Beksac, Sara Bringhen, Eirini Katodritou, Wee-Joo Chng, Xavier Leleu, Shinsuke Iida, María-Victoria Mateos, Gareth Morgan, Alexander Vorog, Richard Labotka, Bingxia Wang, Antonio Palumbo, Sagar Lonial, and on behalf of the TOURMALINE-MM4 study group
Creator:        Arbortext Advanced Print Publisher 9.1.510/W Unicode
Producer:       Acrobat Distiller 10.0.0 (Windows); modified using iText 4.2.0 by 1T3XT
CreationDate:   Tue Nov  3 18:32:06 2020 CET
ModDate:        Wed Feb 17 19:05:00 2021 CET
Tagged:         no
UserProperties: no
Suspects:       no
Form:           none
JavaScript:     no
Pages:          13
Encrypted:      no
Page size:      584.957 x 782.986 pts
Page rot:       0
File size:      882618 bytes
Optimized:      no
PDF version:    1.4


name                                 type              encoding         emb sub uni object ID
------------------------------------ ----------------- ---------------- --- --- --- ---------
OBFNPD+AdvOT463cc31e                 Type 1C           WinAnsi          yes yes no     103  0
OBFNPG+AdvOT8817665d                 Type 1C           WinAnsi          yes yes no     104  0
OBFNPE+AdvOTa82dc243.I               Type 1C           WinAnsi          yes yes no     105  0
OBFOCG+AdvOT53f3fec7                 Type 1C           WinAnsi          yes yes no     106  0
OBFNPF+AdvOTd710a12c+fb              Type 1C           Custom           yes yes yes    107  0
OBFOCH+AdvOT53f3fec7+fb              Type 1C           Custom           yes yes yes    108  0
OBFNNN+AdvTT4350c63d                 Type 1C           WinAnsi          yes yes no     109  0
OBFNNO+AdvOTb03e4648.B               Type 1C           WinAnsi          yes yes no     110  0
OBFNNP+AdvOT8a0d451b.B               Type 1C           WinAnsi          yes yes no     111  0
OBFNOA+AdvOT8a0d451b.B+02            Type 1C           MacRoman         yes yes no     112  0
OBFNOB+AdvOT8a0d451b.B+01            Type 1C           MacRoman         yes yes no     113  0
OBFNOC+AdvOTd710a12c                 Type 1C           WinAnsi          yes yes no     114  0
Times-Roman                          Type 1            WinAnsi          no  no  no       5  0
OBFOLE+AdvOTd710a12c+20              Type 1C           WinAnsi          yes yes no     143  0
OBFONF+Univers                       Type 1C           WinAnsi          yes yes no     160  0
OBFONG+Univers-Bold                  Type 1C           WinAnsi          yes yes no     161  0
OBFPAG+AdvOT8a0d451b.B+fb            Type 1C           Custom           yes yes yes    168  0
OBFPAH+AdvOT9d186844                 Type 1C           WinAnsi          yes yes no     169  0
Helvetica-Bold                       Type 1C           WinAnsi          yes no  no     190  0
OBFPFG+Univers-Oblique               Type 1C           WinAnsi          yes yes no     191  0
OBFPFH+Univers-Condensed             Type 1C           WinAnsi          yes yes no     192  0
OBFPKH+MyriadPro-Regular             Type 1C           Custom           yes yes yes    210  0
OBFPKI+Calibri                       Type 1C           WinAnsi          yes yes no     211  0
OBFPOH+AdvOT72cf81eb.BI              Type 1C           WinAnsi          yes yes no     216  0
OBGAFJ+AdvOTb03e4648.B+20            Type 1C           WinAnsi          yes yes no     251  0
OBGAEH+AdvOT53f3fec7+02              Type 1C           Custom           yes yes no     252  0
OBGAEI+AdvOT53f3fec7+01              Type 1C           MacRoman         yes yes no     253  0
OBGAEG+AdvOT53f3fec7+20              Type 1C           WinAnsi          yes yes no     254  0
OBGAHK+AdvPSUnvNCp                   Type 1C           WinAnsi          yes yes no     260  0
OBGAGJ+AdvOTd710a12c+01              Type 1C           MacRoman         yes yes no     261  0
OBGAIL+AdvOT8a0d451b.B+20            Type 1C           WinAnsi          yes yes no     265  0


Jhove (Rel. 1.22.1, 2019-04-17)
 Date: 2021-02-20 02:30:51 CET
 RepresentationInformation: 236797.pdf
  ReportingModule: PDF-hul, Rel. 1.12.1 (2019-04-17)
  LastModified: 2021-02-17 19:06:30 CET
  Size: 882618
  Format: PDF
  Version: 1.4
  Status: Well-Formed and valid
  SignatureMatches:
   PDF-hul
  MIMEtype: application/pdf
  PDFMetadata: 
   Objects: 0
   FreeObjects: 2
   IncrementalUpdates: 0
   DocumentCatalog: 
    PageLayout: SinglePage
    PageMode: UseNone
    Outlines: 
     Item: 
      Title: Ixazomib as Postinduction Maintenance for Patients With Newly Diagnosed Multiple Myeloma Not Undergoing Autologous Stem Cel ...
      Destination: edu.harvard.hul.ois.jhove.module.pdf.PdfSimpleObject@757942a1
      Children: 
       Item: 
        Title: INTRODUCTION
        Destination: edu.harvard.hul.ois.jhove.module.pdf.PdfSimpleObject@4a87761d
       Item: 
        Title: PATIENTS AND METHODS
        Destination: edu.harvard.hul.ois.jhove.module.pdf.PdfSimpleObject@66d1af89
        Children: 
         Item: 
          Title: Trial Design and Patients
          Destination: edu.harvard.hul.ois.jhove.module.pdf.PdfSimpleObject@8646db9
         Item: 
          Title: Procedures
          Destination: edu.harvard.hul.ois.jhove.module.pdf.PdfSimpleObject@37374a5e
         Item: 
          Title: Outcomes and Assessments
          Destination: edu.harvard.hul.ois.jhove.module.pdf.PdfSimpleObject@4671e53b
         Item: 
          Title: Statistical Analysis
          Destination: edu.harvard.hul.ois.jhove.module.pdf.PdfSimpleObject@2db7a79b
       Item: 
        Title: RESULTS
        Destination: edu.harvard.hul.ois.jhove.module.pdf.PdfSimpleObject@6950e31
        Children: 
         Item: 
          Title: Patients
          Destination: edu.harvard.hul.ois.jhove.module.pdf.PdfSimpleObject@b7dd107
         Item: 
          Title: Efficacy
          Destination: edu.harvard.hul.ois.jhove.module.pdf.PdfSimpleObject@42eca56e
         Item: 
          Title: Treatment Exposure and Safety
          Destination: edu.harvard.hul.ois.jhove.module.pdf.PdfSimpleObject@52f759d7
       Item: 
        Title: DISCUSSION
        Destination: edu.harvard.hul.ois.jhove.module.pdf.PdfSimpleObject@7cbd213e
       Item: 
        Title: REFERENCES
        Destination: edu.harvard.hul.ois.jhove.module.pdf.PdfSimpleObject@192d3247
       Item: 
        Title: jcojcoJCOJournal of Clinical Oncology0732-183XAmerican Society of Clinical Oncology200206010.1200/JCO.20.02060[HEMA32]Targe ...
        Destination: edu.harvard.hul.ois.jhove.module.pdf.PdfSimpleObject@3ecd23d9
   Filters: 
    FilterPipeline: FlateDecode
   Images: 
    Image: 
     NisoImageMetadata: 
      FormatName: image/png
      ImageWidth: 1003
      ImageHeight: 1004
      BitsPerSample: 8
      BitsPerSampleUnit: integer
     Filter: FlateDecode
     ColorSpace: CalRGB
     Intent: Perceptual
    Image: 
     NisoImageMetadata: 
      FormatName: image/png
      ImageWidth: 1003
      ImageHeight: 1004
      ColorSpace: black is zero
      BitsPerSample: 8
      BitsPerSampleUnit: integer
     Filter: FlateDecode
   Fonts: 
    Type1: 
     Font: 
      BaseFont: OBFPFH+Univers-Condensed
      FontSubset: true
      FirstChar: 32
      LastChar: 122
      FontDescriptor: 
       FontName: OBFPFH+Univers-Condensed
       Flags: Nonsymbolic
       FontBBox: -166, -250, 1000, 989
       FontFile3: true
      Encoding: WinAnsiEncoding
     Font: 
      BaseFont: OBGAHK+AdvPSUnvNCp
      FontSubset: true
      FirstChar: 110
      LastChar: 110
      FontDescriptor: 
       FontName: OBGAHK+AdvPSUnvNCp
       Flags: Nonsymbolic
       FontBBox: 0, -218, 989, 760
       FontFile3: true
      Encoding: WinAnsiEncoding
     Font: 
      BaseFont: OBGAGJ+AdvOTd710a12c+01
      FontSubset: true
      FirstChar: 245
      LastChar: 245
      FontDescriptor: 
       FontName: OBGAGJ+AdvOTd710a12c+01
       Flags: Nonsymbolic
       FontBBox: 0, -177, 958, 885
       FontFile3: true
      Encoding: MacRomanEncoding
     Font: 
      BaseFont: OBGAIL+AdvOT8a0d451b.B+20
      FontSubset: true
      FirstChar: 146
      LastChar: 146
      FontDescriptor: 
       FontName: OBGAIL+AdvOT8a0d451b.B+20
       Flags: Nonsymbolic
       FontBBox: -166, -145, 1000, 729
       FontFile3: true
      Encoding: WinAnsiEncoding
     Font: 
      BaseFont: OBFOLE+AdvOTd710a12c+20
      FontSubset: true
      FirstChar: 134
      LastChar: 151
      FontDescriptor: 
       FontName: OBFOLE+AdvOTd710a12c+20
       Flags: Nonsymbolic
       FontBBox: -166, -145, 1000, 729
       FontFile3: true
      Encoding: WinAnsiEncoding
     Font: 
      BaseFont: OBFPKH+MyriadPro-Regular
      FontSubset: true
      FirstChar: 1
      LastChar: 32
      FontDescriptor: 
       FontName: OBFPKH+MyriadPro-Regular
       Flags: Symbolic
       FontBBox: -157, -250, 1126, 952
       FontFile3: true
      EncodingDictionary: 
       Differences: true
      ToUnicode: true
     Font: 
      BaseFont: OBFPKI+Calibri
      FontSubset: true
      FirstChar: 32
      LastChar: 111
      FontDescriptor: 
       FontName: OBFPKI+Calibri
       Flags: Nonsymbolic
       FontBBox: -503, -307, 1240, 964
       FontFile3: true
      Encoding: WinAnsiEncoding
     Font: 
      BaseFont: OBFPOH+AdvOT72cf81eb.BI
      FontSubset: true
      FirstChar: 80
      LastChar: 80
      FontDescriptor: 
       FontName: OBFPOH+AdvOT72cf81eb.BI
       Flags: Nonsymbolic
       FontBBox: -52, -270, 1072, 968
       FontFile3: true
      Encoding: WinAnsiEncoding
     Font: 
      BaseFont: OBFONF+Univers
      FontSubset: true
      FirstChar: 32
      LastChar: 182
      FontDescriptor: 
       FontName: OBFONF+Univers
       Flags: Nonsymbolic
       FontBBox: -168, -250, 992, 947
       FontFile3: true
      Encoding: WinAnsiEncoding
     Font: 
      BaseFont: OBFONG+Univers-Bold
      FontSubset: true
      FirstChar: 32
      LastChar: 122
      FontDescriptor: 
       FontName: OBFONG+Univers-Bold
       Flags: Nonsymbolic, ForceBold
       FontBBox: -167, -250, 995, 938
       FontFile3: true
      Encoding: WinAnsiEncoding
     Font: 
      BaseFont: OBFNPD+AdvOT463cc31e
      FontSubset: true
      FirstChar: 44
      LastChar: 53
      FontDescriptor: 
       FontName: OBFNPD+AdvOT463cc31e
       Flags: Nonsymbolic
       FontBBox: -20, -239, 989, 812
       FontFile3: true
      Encoding: WinAnsiEncoding
     Font: 
      BaseFont: OBFNPG+AdvOT8817665d
      FontSubset: true
      FirstChar: 35
      LastChar: 36
      FontDescriptor: 
       FontName: OBFNPG+AdvOT8817665d
       Flags: Nonsymbolic
       FontBBox: -20, -208, 1000, 770
       FontFile3: true
      Encoding: WinAnsiEncoding
     Font: 
      BaseFont: OBFPAG+AdvOT8a0d451b.B+fb
      FontSubset: true
      FirstChar: 1
      LastChar: 1
      FontDescriptor: 
       FontName: OBFPAG+AdvOT8a0d451b.B+fb
       Flags: Symbolic
       FontBBox: 9, 0, 489, 729
       FontFile3: true
      EncodingDictionary: 
       Differences: true
      ToUnicode: true
     Font: 
      BaseFont: OBFNPE+AdvOTa82dc243.I
      FontSubset: true
      FirstChar: 80
      LastChar: 118
      FontDescriptor: 
       FontName: OBFNPE+AdvOTa82dc243.I
       Flags: Nonsymbolic
       FontBBox: -52, -270, 1041, 947
       FontFile3: true
      Encoding: WinAnsiEncoding
     Font: 
      BaseFont: OBFPAH+AdvOT9d186844
      FontSubset: true
      FirstChar: 53
      LastChar: 53
      FontDescriptor: 
       FontName: OBFPAH+AdvOT9d186844
       Flags: Nonsymbolic
       FontBBox: -20, -239, 927, 770
       FontFile3: true
      Encoding: WinAnsiEncoding
     Font: 
      BaseFont: OBFOCG+AdvOT53f3fec7
      FontSubset: true
      FirstChar: 40
      LastChar: 180
      FontDescriptor: 
       FontName: OBFOCG+AdvOT53f3fec7
       Flags: Nonsymbolic
       FontBBox: -10, -218, 947, 958
       FontFile3: true
      Encoding: WinAnsiEncoding
     Font: 
      BaseFont: OBFNPF+AdvOTd710a12c+fb
      FontSubset: true
      FirstChar: 1
      LastChar: 3
      FontDescriptor: 
       FontName: OBFNPF+AdvOTd710a12c+fb
       Flags: Symbolic
       FontBBox: 0, 0, 500, 729
       FontFile3: true
      EncodingDictionary: 
       Differences: true
      ToUnicode: true
     Font: 
      BaseFont: OBFOCH+AdvOT53f3fec7+fb
      FontSubset: true
      FirstChar: 1
      LastChar: 1
      FontDescriptor: 
       FontName: OBFOCH+AdvOT53f3fec7+fb
       Flags: Symbolic
       FontBBox: 0, 0, 500, 729
       FontFile3: true
      EncodingDictionary: 
       Differences: true
      ToUnicode: true
     Font: 
      BaseFont: OBFNNN+AdvTT4350c63d
      FontSubset: true
      FirstChar: 97
      LastChar: 116
      FontDescriptor: 
       FontName: OBFNNN+AdvTT4350c63d
       Flags: Serif, Nonsymbolic
       FontBBox: -31, -302, 895, 802
       FontFile3: true
      Encoding: WinAnsiEncoding
     Font: 
      BaseFont: OBFNNO+AdvOTb03e4648.B
      FontSubset: true
      FirstChar: 37
      LastChar: 169
      FontDescriptor: 
       FontName: OBFNNO+AdvOTb03e4648.B
       Flags: Nonsymbolic
       FontBBox: -52, -218, 927, 968
       FontFile3: true
      Encoding: WinAnsiEncoding
     Font: 
      BaseFont: OBFNNP+AdvOT8a0d451b.B
      FontSubset: true
      FirstChar: 44
      LastChar: 180
      FontDescriptor: 
       FontName: OBFNNP+AdvOT8a0d451b.B
       Flags: Nonsymbolic
       FontBBox: -31, -218, 895, 968
       FontFile3: true
      Encoding: WinAnsiEncoding
     Font: 
      BaseFont: OBFNOA+AdvOT8a0d451b.B+02
      FontSubset: true
      FirstChar: 255
      LastChar: 255
      FontDescriptor: 
       FontName: OBFNOA+AdvOT8a0d451b.B+02
       Flags: Nonsymbolic
       FontBBox: -41, -208, 375, 791
       FontFile3: true
      Encoding: MacRomanEncoding
     Font: 
      BaseFont: OBFNOB+AdvOT8a0d451b.B+01
      FontSubset: true
      FirstChar: 245
      LastChar: 245
      FontDescriptor: 
       FontName: OBFNOB+AdvOT8a0d451b.B+01
       Flags: Nonsymbolic
       FontBBox: 0, -187, 916, 906
       FontFile3: true
      Encoding: MacRomanEncoding
     Font: 
      BaseFont: OBFNOC+AdvOTd710a12c
      FontSubset: true
      FirstChar: 37
      LastChar: 241
      FontDescriptor: 
       FontName: OBFNOC+AdvOTd710a12c
       Flags: Nonsymbolic
       FontBBox: -31, -208, 895, 947
       FontFile3: true
      Encoding: WinAnsiEncoding
     Font: 
      BaseFont: OBGAFJ+AdvOTb03e4648.B+20
      FontSubset: true
      FirstChar: 146
      LastChar: 146
      FontDescriptor: 
       FontName: OBGAFJ+AdvOTb03e4648.B+20
       Flags: Nonsymbolic
       FontBBox: -166, -145, 1000, 729
       FontFile3: true
      Encoding: WinAnsiEncoding
     Font: 
      BaseFont: OBGAEH+AdvOT53f3fec7+02
      FontSubset: true
      FirstChar: 24
      LastChar: 136
      FontDescriptor: 
       FontName: OBGAEH+AdvOT53f3fec7+02
       Flags: Nonsymbolic
       FontBBox: -31, -208, 500, 770
       FontFile3: true
      EncodingDictionary: 
       BaseEncoding: WinAnsiEncoding
       Differences: true
     Font: 
      BaseFont: OBGAEI+AdvOT53f3fec7+01
      FontSubset: true
      FirstChar: 245
      LastChar: 245
      FontDescriptor: 
       FontName: OBGAEI+AdvOT53f3fec7+01
       Flags: Nonsymbolic
       FontBBox: 0, -187, 958, 895
       FontFile3: true
      Encoding: MacRomanEncoding
     Font: 
      BaseFont: Helvetica-Bold
      FirstChar: 0
      LastChar: 255
      FontDescriptor: 
       FontName: Helvetica-Bold
       Flags: Nonsymbolic, ForceBold
       FontBBox: -170, -228, 1003, 962
       FontFile3: true
      Encoding: WinAnsiEncoding
     Font: 
      BaseFont: OBGAEG+AdvOT53f3fec7+20
      FontSubset: true
      FirstChar: 146
      LastChar: 146
      FontDescriptor: 
       FontName: OBGAEG+AdvOT53f3fec7+20
       Flags: Nonsymbolic
       FontBBox: -166, -135, 1000, 729
       FontFile3: true
      Encoding: WinAnsiEncoding
     Font: 
      BaseFont: OBFPFG+Univers-Oblique
      FontSubset: true
      FirstChar: 32
      LastChar: 80
      FontDescriptor: 
       FontName: OBFPFG+Univers-Oblique
       Flags: Nonsymbolic, Italic
       FontBBox: -174, -250, 1145, 947
       FontFile3: true
      Encoding: WinAnsiEncoding
   XMP: <x:xmpmeta xmlns:x="adobe:ns:meta/">
<rdf:RDF xmlns:rdf="http://www.w3.org/1999/02/22-rdf-syntax-ns#">
<rdf:Description rdf:about="" xmlns:dc="http://purl.org/dc/elements/1.1/"><dc:format>application/pdf</dc:format><dc:identifier>doi:10.1200/JCO.20.02060</dc:identifier></rdf:Description>
<rdf:Description rdf:about="" xmlns:prism="http://prismstandard.org/namespaces/basic/2.1/"><prism:doi>10.1200/JCO.20.02060</prism:doi><prism:url>https://doi.org/10.1200/JCO.20.02060</prism:url></rdf:Description>
<rdf:Description rdf:about="" xmlns:crossmark="http://crossref.org/crossmark/1.0/"><crossmark:MajorVersionDate>2020-10-06</crossmark:MajorVersionDate><crossmark:CrossmarkDomainExclusive>true</crossmark:CrossmarkDomainExclusive><crossmark:CrossMarkDomains><rdf:Seq><rdf:li>ascopubs.org</rdf:li></rdf:Seq></crossmark:CrossMarkDomains><crossmark:DOI>10.1200/JCO.20.02060</crossmark:DOI></rdf:Description>
<rdf:Description rdf:about="" xmlns:pdfx="http://ns.adobe.com/pdfx/1.3/"><pdfx:CrossMarkDomains><rdf:Seq><rdf:li>ascopubs.org</rdf:li></rdf:Seq></pdfx:CrossMarkDomains><pdfx:CrossmarkDomainExclusive>true</pdfx:CrossmarkDomainExclusive><pdfx:CrossmarkMajorVersionDate>2020-10-06</pdfx:CrossmarkMajorVersionDate><pdfx:doi>10.1200/JCO.20.02060</pdfx:doi></rdf:Description>
</rdf:RDF></x:xmpmeta>
   Pages: 
    Page: 
     Label: 1
     Annotations: 
      Annotation: 
       Subtype: Link
       Rect: 291, 148, 295, 157
       Destination: 81
      Annotation: 
       Subtype: Link
       Rect: 297, 148, 300, 157
       Destination: 81
      Annotation: 
       Subtype: Link
       Rect: 155, 112, 158, 120
       Destination: 81
      Annotation: 
       Subtype: Link
       Rect: 160, 112, 163, 120
       Destination: 81
      Annotation: 
       Subtype: Link
       Rect: 213, 76, 216, 84
       Destination: 81
      Annotation: 
       Subtype: Link
       Rect: 468, 188, 471, 197
       Destination: 81
      Annotation: 
       Subtype: Link
       Rect: 472, 164, 476, 173
       Destination: 81
      Annotation: 
       Subtype: Link
       Rect: 477, 164, 481, 173
       Destination: 82
      Annotation: 
       Subtype: Link
       Rect: 533, 124, 539, 132
       Destination: 82
      Annotation: 
       Subtype: Link
       Rect: 541, 124, 548, 132
       Destination: 82
      Annotation: 
       Subtype: Link
       Rect: 493, 100, 500, 108
       Destination: 82
      Annotation: 
       Subtype: Link
       Rect: 36, 226, 89, 233
      Annotation: 
       Subtype: Link
       Rect: 36, 216, 62, 223
      Annotation: 
       Subtype: Link
       Rect: 36, 112, 103, 120
      Annotation: 
       Subtype: Link
       Rect: 36, 102, 46, 110
      Annotation: 
       Subtype: Link
       Rect: 70, 92, 103, 100
      Annotation: 
       Subtype: Link
       Rect: 36, 82, 100, 90
      Annotation: 
       Subtype: Link
       Rect: 36, 72, 57, 80
      Annotation: 
       Subtype: Link
       Rect: 532, 762, 577, 717
     Thumb: true
    Page: 
     Label: 2
     Annotations: 
      Annotation: 
       Subtype: Link
       Rect: 139, 451, 143, 460
       Destination: 82
      Annotation: 
       Subtype: Link
       Rect: 144, 451, 150, 460
       Destination: 82
      Annotation: 
       Subtype: Link
       Rect: 152, 451, 158, 460
       Destination: 82
      Annotation: 
       Subtype: Link
       Rect: 250, 451, 253, 460
       Destination: 81
      Annotation: 
       Subtype: Link
       Rect: 255, 451, 261, 460
       Destination: 82
      Annotation: 
       Subtype: Link
       Rect: 216, 427, 220, 436
       Destination: 81
      Annotation: 
       Subtype: Link
       Rect: 221, 427, 227, 436
       Destination: 82
      Annotation: 
       Subtype: Link
       Rect: 213, 392, 219, 400
       Destination: 82
      Annotation: 
       Subtype: Link
       Rect: 262, 352, 269, 360
       Destination: 82
      Annotation: 
       Subtype: Link
       Rect: 139, 328, 146, 336
       Destination: 82
      Annotation: 
       Subtype: Link
       Rect: 164, 316, 171, 324
       Destination: 82
      Annotation: 
       Subtype: Link
       Rect: 173, 316, 179, 324
       Destination: 82
      Annotation: 
       Subtype: Link
       Rect: 301, 88, 307, 96
       Destination: 82
     Thumb: true
    Page: 
     Label: 3
     Annotations: 
      Annotation: 
       Subtype: Link
       Rect: 90, 609, 97, 617
       Destination: 82
     Thumb: true
    Page: 
     Label: 4
     Annotations: 
      Annotation: 
       Subtype: Link
       Rect: 538, 578, 544, 586
       Destination: 82
      Annotation: 
       Subtype: Link
       Rect: 376, 444, 396, 453
       Destination: 73
      Annotation: 
       Subtype: Link
       Rect: 493, 408, 524, 418
       Destination: 74
      Annotation: 
       Subtype: Link
       Rect: 489, 230, 516, 240
       Destination: 76
      Annotation: 
       Subtype: Link
       Rect: 320, 183, 351, 192
       Destination: 78
     Thumb: true
    Page: 
     Label: 5
     Annotations: 
      Annotation: 
       Subtype: Link
       Rect: 342, 717, 372, 727
       Destination: 78
      Annotation: 
       Subtype: Link
       Rect: 380, 705, 420, 715
       Destination: 76
      Annotation: 
       Subtype: Link
       Rect: 355, 653, 385, 662
       Destination: 78
      Annotation: 
       Subtype: Link
       Rect: 495, 578, 515, 587
       Destination: 73
      Annotation: 
       Subtype: Link
       Rect: 481, 566, 512, 576
       Destination: 79
      Annotation: 
       Subtype: Link
       Rect: 320, 406, 350, 415
       Destination: 79
      Annotation: 
       Subtype: Link
       Rect: 464, 358, 493, 367
       Destination: 80
      Annotation: 
       Subtype: Link
       Rect: 430, 274, 459, 284
       Destination: 80
      Annotation: 
       Subtype: Link
       Rect: 457, 155, 488, 164
       Destination: 80
      Annotation: 
       Subtype: Link
       Rect: 428, 131, 459, 140
       Destination: 80
     Thumb: true
    Page: 
     Label: 6
     Annotations: 
      Annotation: 
       Subtype: Link
       Rect: 122, 339, 129, 347
       Destination: 82
      Annotation: 
       Subtype: Link
       Rect: 301, 148, 307, 156
       Destination: 82
      Annotation: 
       Subtype: Link
       Rect: 394, 474, 400, 482
       Destination: 82
      Annotation: 
       Subtype: Link
       Rect: 402, 474, 408, 482
       Destination: 82
      Annotation: 
       Subtype: Link
       Rect: 409, 474, 416, 482
       Destination: 82
      Annotation: 
       Subtype: Link
       Rect: 392, 458, 448, 467
      Annotation: 
       Subtype: Link
       Rect: 378, 425, 385, 433
       Destination: 82
      Annotation: 
       Subtype: Link
       Rect: 488, 273, 495, 281
       Destination: 82
      Annotation: 
       Subtype: Link
       Rect: 352, 248, 359, 256
       Destination: 82
      Annotation: 
       Subtype: Link
       Rect: 473, 224, 479, 232
       Destination: 82
      Annotation: 
       Subtype: Link
       Rect: 352, 150, 359, 158
       Destination: 82
      Annotation: 
       Subtype: Link
       Rect: 484, 150, 491, 158
       Destination: 82
      Annotation: 
       Subtype: Link
       Rect: 541, 88, 548, 96
       Destination: 82
     Thumb: true
    Page: 
     Label: 7
     Thumb: true
    Page: 
     Label: 8
     Annotations: 
      Annotation: 
       Subtype: Link
       Rect: 127, 433, 134, 441
       Destination: 82
      Annotation: 
       Subtype: Link
       Rect: 136, 433, 142, 441
       Destination: 82
      Annotation: 
       Subtype: Link
       Rect: 144, 433, 151, 441
       Destination: 82
      Annotation: 
       Subtype: Link
       Rect: 153, 433, 160, 441
       Destination: 82
      Annotation: 
       Subtype: Link
       Rect: 205, 397, 212, 405
       Destination: 82
      Annotation: 
       Subtype: Link
       Rect: 301, 397, 307, 405
       Destination: 82
      Annotation: 
       Subtype: Link
       Rect: 169, 385, 176, 393
       Destination: 82
      Annotation: 
       Subtype: Link
       Rect: 514, 336, 521, 344
       Destination: 82
      Annotation: 
       Subtype: Link
       Rect: 522, 336, 529, 344
       Destination: 82
      Annotation: 
       Subtype: Link
       Rect: 368, 323, 375, 332
       Destination: 82
      Annotation: 
       Subtype: Link
       Rect: 377, 323, 383, 332
       Destination: 82
      Annotation: 
       Subtype: Link
       Rect: 385, 323, 392, 332
       Destination: 82
      Annotation: 
       Subtype: Link
       Rect: 394, 323, 401, 332
       Destination: 82
      Annotation: 
       Subtype: Link
       Rect: 469, 323, 472, 332
       Destination: 81
      Annotation: 
       Subtype: Link
       Rect: 418, 270, 425, 278
       Destination: 82
      Annotation: 
       Subtype: Link
       Rect: 426, 270, 433, 278
       Destination: 82
      Annotation: 
       Subtype: Link
       Rect: 435, 270, 442, 278
       Destination: 82
      Annotation: 
       Subtype: Link
       Rect: 443, 270, 450, 278
       Destination: 82
      Annotation: 
       Subtype: Link
       Rect: 531, 270, 535, 278
       Destination: 81
      Annotation: 
       Subtype: Link
       Rect: 518, 234, 526, 242
       Destination: 82
      Annotation: 
       Subtype: Link
       Rect: 462, 137, 469, 145
       Destination: 82
     Thumb: true
    Page: 
     Label: 9
     Annotations: 
      Annotation: 
       Subtype: Link
       Rect: 270, 197, 277, 206
       Destination: 82
      Annotation: 
       Subtype: Link
       Rect: 301, 149, 307, 157
       Destination: 82
      Annotation: 
       Subtype: Link
       Rect: 104, 112, 112, 121
       Destination: 82
      Annotation: 
       Subtype: Link
       Rect: 261, 88, 267, 96
       Destination: 82
      Annotation: 
       Subtype: Link
       Rect: 246, 76, 253, 84
       Destination: 82
      Annotation: 
       Subtype: Link
       Rect: 435, 243, 441, 252
       Destination: 82
      Annotation: 
       Subtype: Link
       Rect: 443, 243, 450, 252
       Destination: 82
     Thumb: true
    Page: 
     Label: 10
     Thumb: true
    Page: 
     Label: 11
     Annotations: 
      Annotation: 
       Subtype: Link
       Rect: 237, 306, 305, 313
      Annotation: 
       Subtype: Link
       Rect: 317, 642, 368, 649
      Annotation: 
       Subtype: Link
       Rect: 317, 585, 444, 592
     Thumb: true
    Page: 
     Label: 12
     Annotations: 
      Annotation: 
       Subtype: Link
       Rect: 308, 546, 460, 553
     Thumb: true
    Page: 
     Label: 13
     Annotations: 
      Annotation: 
       Subtype: Link
       Rect: 306, 682, 358, 688
      Annotation: 
       Subtype: Link
       Rect: 369, 682, 484, 688
      Annotation: 
       Subtype: Link
       Rect: 477, 669, 524, 676
     Thumb: true
  Checksum: 5c28c494
   Type: CRC32
  Checksum: 4241b529b2a352f880475b9dc0448bdc
   Type: MD5
  Checksum: c1bea488ecc6d4e6ab60c35a0bbb0d8c8a6c00e2
   Type: SHA-1