05ff25823ecedd877a6c7fb0b3ca6043  236888.pdf
d98fcf4ffda02887cea34d1562d46fd63463b237  236888.pdf
3cd804b3be107e4fc386de90512b3dc028b3861a1f554909d41266b73e3c390f  236888.pdf

Title:          Quantitative PCR Is Faster, More Objective, and More Reliable Than Immunohistochemistry for the Diagnosis of Cytomegalovirus Gastrointestinal Disease in Allogeneic Stem Cell Transplantation
Subject:        Biology of Blood and Marrow Transplantation, 25 (2019) 2281-2286. doi:10.1016/j.bbmt.2019.07.016
Keywords:       Possible CMV disease; Quantitative PCR; Gastrointestinal tissue; Allo-SCT
Author:         María Suárez-Lledó
Creator:        Elsevier
Producer:       Acrobat Distiller 10.1.16 (Windows)
CreationDate:   Thu Oct 31 14:41:23 2019 CET
ModDate:        Thu Oct 31 14:41:44 2019 CET
Tagged:         yes
UserProperties: no
Suspects:       no
Form:           none
JavaScript:     no
Pages:          6
Encrypted:      no
Page size:      593.858 x 792 pts
Page rot:       0
File size:      387537 bytes
Optimized:      yes
PDF version:    1.7


name                                 type              encoding         emb sub uni object ID
------------------------------------ ----------------- ---------------- --- --- --- ---------
ADNNDP+AdvP4A5FDB                    Type 1C           WinAnsi          yes yes no     250  0
ADNNDN+AdvOT5fa4e291+fb              Type 1C           Custom           yes yes yes    253  0
ADNNCM+AdvOTf2586c63+20              Type 1C           WinAnsi          yes yes no     258  0
ADOEBG+AdvPAC3D                      Type 1C           WinAnsi          yes yes no     261  0
ADNNDM+AdvOT5fa4e291+20              Type 1C           WinAnsi          yes yes no     264  0
ADNNCJ+AdvOT5fa4e291                 Type 1C           WinAnsi          yes yes no     267  0
ADNNCL+AdvOTf2586c63                 Type 1C           WinAnsi          yes yes no     270  0
ADNNDO+AdvP4C9542                    Type 1C           WinAnsi          yes yes no     273  0
ADNNEB+AdvP4C4E74                    Type 1C           Custom           yes yes no     276  0
ADNNEA+AdvTTb83ee1dd.B               Type 1C           WinAnsi          yes yes no     280  0
ADNNCK+AdvP4C4E59                    Type 1C           Custom           yes yes yes    283  0
ADOEJD+AdvOT1be73566.B               Type 1C           WinAnsi          yes yes no     127  0
ADOEKF+AdvP4C9543                    Type 1C           Custom           yes yes yes    130  0
ADOEKG+AdvOT1be73566.B+fb            Type 1C           Custom           yes yes yes    135  0
ADOEKE+AdvOTf2586c63+fb              Type 1C           Custom           yes yes yes    140  0
ADOFBE+Calibri                       Type 1C           Custom           yes yes yes     21  0


Jhove (Rel. 1.22.1, 2019-04-17)
 Date: 2021-02-24 02:25:31 CET
 RepresentationInformation: 236888.pdf
  ReportingModule: PDF-hul, Rel. 1.12.1 (2019-04-17)
  LastModified: 2021-02-20 11:30:31 CET
  Size: 387537
  Format: PDF
  Version: 1.7
  Status: Well-Formed and valid
  SignatureMatches:
   PDF-hul
  MIMEtype: application/pdf
  Profile: Linearized PDF
  PDFMetadata: 
   Objects: 372
   FreeObjects: 1
   IncrementalUpdates: 1
   DocumentCatalog: 
    ViewerPreferences: 
     HideToolbar: false
     HideMenubar: false
     HideWindowUI: false
     FitWindow: false
     CenterWindow: false
     DisplayDocTitle: true
     NonFullScreenPageMode: UseNone
     Direction: L2R
     ViewArea: CropBox
     ViewClip: CropBox
     PrintArea: CropBox
     PageClip: CropBox
    PageLayout: SinglePage
    PageMode: UseOutlines
    Outlines: 
     Item: 
      Title: Quantitative PCR Is Faster, More Objective, and More Reliable Than Immunohistochemistry for the Diagnosis of Cytomegalovirus Gastrointestinal Disease in Allogeneic Stem Cell Transplantation
      Destination: edu.harvard.hul.ois.jhove.module.pdf.PdfSimpleObject@1060b431
      Children: 
       Item: 
        Title: INTRODUCTION
        Destination: edu.harvard.hul.ois.jhove.module.pdf.PdfSimpleObject@612679d6
       Item: 
        Title: METHODS
        Destination: edu.harvard.hul.ois.jhove.module.pdf.PdfSimpleObject@11758f2a
        Children: 
         Item: 
          Title: General
          Destination: edu.harvard.hul.ois.jhove.module.pdf.PdfSimpleObject@e720b71
         Item: 
          Title: Microbiological Assessment
          Destination: edu.harvard.hul.ois.jhove.module.pdf.PdfSimpleObject@1b26f7b2
         Item: 
          Title: Definitions (Ljungman et al CID, 2017 [20])
          Destination: edu.harvard.hul.ois.jhove.module.pdf.PdfSimpleObject@491cc5c9
          Children: 
           Item: 
            Title: Endoscopic Procedure
            Destination: edu.harvard.hul.ois.jhove.module.pdf.PdfSimpleObject@74ad1f1f
           Item: 
            Title: Immunohistochemistry
            Destination: edu.harvard.hul.ois.jhove.module.pdf.PdfSimpleObject@6a1aab78
           Item: 
            Title: qPCR
            Destination: edu.harvard.hul.ois.jhove.module.pdf.PdfSimpleObject@462d5aee
         Item: 
          Title: Statistical Analysis
          Destination: edu.harvard.hul.ois.jhove.module.pdf.PdfSimpleObject@69b0fd6f
       Item: 
        Title: RESULTS
        Destination: edu.harvard.hul.ois.jhove.module.pdf.PdfSimpleObject@757942a1
        Children: 
         Item: 
          Title: Paraffin Samples Group
          Destination: edu.harvard.hul.ois.jhove.module.pdf.PdfSimpleObject@4a87761d
         Item: 
          Title: Fresh Samples
          Destination: edu.harvard.hul.ois.jhove.module.pdf.PdfSimpleObject@66d1af89
       Item: 
        Title: DISCUSSION
        Destination: edu.harvard.hul.ois.jhove.module.pdf.PdfSimpleObject@8646db9
       Item: 
        Title: Declaration of Competing Interest
        Destination: edu.harvard.hul.ois.jhove.module.pdf.PdfSimpleObject@37374a5e
       Item: 
        Title: ACKNOWLEDGMENTS
        Destination: edu.harvard.hul.ois.jhove.module.pdf.PdfSimpleObject@4671e53b
       Item: 
        Title: REFERENCES
        Destination: edu.harvard.hul.ois.jhove.module.pdf.PdfSimpleObject@2db7a79b
   Info: 
    Title: Quantitative PCR Is Faster, More Objective, and More Reliable Than Immunohistochemistry for the Diagnosis of Cytomegalovirus Gastrointestinal Disease in Allogeneic Stem Cell Transplantation
    Author: María Suárez-Lledó
    Subject: Biology of Blood and Marrow Transplantation, 25 (2019) 2281-2286. doi:10.1016/j.bbmt.2019.07.016
    Keywords: Possible CMV disease; Quantitative PCR; Gastrointestinal tissue; Allo-SCT
    Creator: Elsevier
    Producer: Acrobat Distiller 10.1.16 (Windows)
    CreationDate: Thu Oct 31 15:11:23 CET 2019
    ModDate: Thu Oct 31 15:11:44 CET 2019
   ID: 0x2173a6f91c6aeac470c34c4b063096a9, 0x4e2c6798ab3d6dff7377834f10411359
   Filters: 
    FilterPipeline: FlateDecode
    FilterPipeline: DCTDecode
   Images: 
    Image: 
     NisoImageMetadata: 
      FormatName: image/jpg
      CompressionScheme: JPEG
      ImageWidth: 366
      ImageHeight: 214
      ColorSpace: RGB
      BitsPerSample: 8
      BitsPerSampleUnit: integer
   Fonts: 
    Type1: 
     Font: 
      BaseFont: ADNNCM+AdvOTf2586c63+20
      FontSubset: true
      FirstChar: 146
      LastChar: 146
      FontDescriptor: 
       FontName: ADNNCM+AdvOTf2586c63+20
       Flags: Nonsymbolic
       FontBBox: -41, -208, 885, 781
       FontFile3: true
      Encoding: WinAnsiEncoding
     Font: 
      BaseFont: ADOEKF+AdvP4C9543
      FontSubset: true
      FirstChar: 2
      LastChar: 163
      FontDescriptor: 
       FontName: ADOEKF+AdvP4C9543
       Flags: Symbolic
       FontBBox: 0, -947, 1041, 895
       FontFile3: true
      EncodingDictionary: 
       Differences: true
      ToUnicode: true
     Font: 
      BaseFont: ADOEBG+AdvPAC3D
      FontSubset: true
      FirstChar: 46
      LastChar: 119
      FontDescriptor: 
       FontName: ADOEBG+AdvPAC3D
       Flags: Nonsymbolic
       FontBBox: -166, -239, 989, 791
       FontFile3: true
      Encoding: WinAnsiEncoding
     Font: 
      BaseFont: ADOEKG+AdvOT1be73566.B+fb
      FontSubset: true
      FirstChar: 1
      LastChar: 1
      FontDescriptor: 
       FontName: ADOEKG+AdvOT1be73566.B+fb
       Flags: Symbolic
       FontBBox: -156, -208, 916, 781
       FontFile3: true
      EncodingDictionary: 
       Differences: true
      ToUnicode: true
     Font: 
      BaseFont: ADNNDM+AdvOT5fa4e291+20
      FontSubset: true
      FirstChar: 146
      LastChar: 150
      FontDescriptor: 
       FontName: ADNNDM+AdvOT5fa4e291+20
       Flags: Nonsymbolic
       FontBBox: 19, -208, 947, 781
       FontFile3: true
      Encoding: WinAnsiEncoding
     Font: 
      BaseFont: ADNNCJ+AdvOT5fa4e291
      FontSubset: true
      FirstChar: 37
      LastChar: 237
      FontDescriptor: 
       FontName: ADNNCJ+AdvOT5fa4e291
       Flags: Serif, Nonsymbolic
       FontBBox: -72, -250, 1041, 979
       FontFile3: true
      Encoding: WinAnsiEncoding
     Font: 
      BaseFont: ADOEKE+AdvOTf2586c63+fb
      FontSubset: true
      FirstChar: 1
      LastChar: 3
      FontDescriptor: 
       FontName: ADOEKE+AdvOTf2586c63+fb
       Flags: Symbolic
       FontBBox: -114, -208, 833, 781
       FontFile3: true
      EncodingDictionary: 
       Differences: true
      ToUnicode: true
     Font: 
      BaseFont: ADNNCL+AdvOTf2586c63
      FontSubset: true
      FirstChar: 40
      LastChar: 237
      FontDescriptor: 
       FontName: ADNNCL+AdvOTf2586c63
       Flags: Serif, Nonsymbolic
       FontBBox: -135, -229, 1052, 968
       FontFile3: true
      Encoding: WinAnsiEncoding
     Font: 
      BaseFont: ADNNDO+AdvP4C9542
      FontSubset: true
      FirstChar: 60
      LastChar: 62
      FontDescriptor: 
       FontName: ADNNDO+AdvP4C9542
       Flags: Nonsymbolic
       FontBBox: 0, -208, 979, 677
       FontFile3: true
      Encoding: WinAnsiEncoding
     Font: 
      BaseFont: ADNNEB+AdvP4C4E74
      FontSubset: true
      FirstChar: 1
      LastChar: 3
      FontDescriptor: 
       FontName: ADNNEB+AdvP4C4E74
       Flags: Symbolic
       FontBBox: -20, -958, 1114, 770
       FontFile3: true
      EncodingDictionary: 
       Differences: true
     Font: 
      BaseFont: ADOFBE+Calibri
      FontSubset: true
      FirstChar: 2
      LastChar: 142
      FontDescriptor: 
       FontName: ADOFBE+Calibri
       Flags: Serif, Symbolic
       FontBBox: -503, -307, 1240, 964
       FontFile3: true
      EncodingDictionary: 
       Differences: true
      ToUnicode: true
     Font: 
      BaseFont: ADNNEA+AdvTTb83ee1dd.B
      FontSubset: true
      FirstChar: 40
      LastChar: 117
      FontDescriptor: 
       FontName: ADNNEA+AdvTTb83ee1dd.B
       Flags: Nonsymbolic
       FontBBox: -93, -250, 1041, 989
       FontFile3: true
      Encoding: WinAnsiEncoding
     Font: 
      BaseFont: ADNNDP+AdvP4A5FDB
      FontSubset: true
      FirstChar: 109
      LastChar: 109
      FontDescriptor: 
       FontName: ADNNDP+AdvP4A5FDB
       Flags: Nonsymbolic
       FontBBox: 0, -239, 979, 718
       FontFile3: true
      Encoding: WinAnsiEncoding
     Font: 
      BaseFont: ADNNCK+AdvP4C4E59
      FontSubset: true
      FirstChar: 1
      LastChar: 126
      FontDescriptor: 
       FontName: ADNNCK+AdvP4C4E59
       Flags: Symbolic
       FontBBox: -31, -250, 1000, 750
       FontFile3: true
      EncodingDictionary: 
       Differences: true
      ToUnicode: true
     Font: 
      BaseFont: ADNNDN+AdvOT5fa4e291+fb
      FontSubset: true
      FirstChar: 1
      LastChar: 3
      FontDescriptor: 
       FontName: ADNNDN+AdvOT5fa4e291+fb
       Flags: Symbolic
       FontBBox: 40, 0, 572, 781
       FontFile3: true
      EncodingDictionary: 
       Differences: true
      ToUnicode: true
     Font: 
      BaseFont: ADOEJD+AdvOT1be73566.B
      FontSubset: true
      FirstChar: 40
      LastChar: 121
      FontDescriptor: 
       FontName: ADOEJD+AdvOT1be73566.B
       Flags: Serif, Nonsymbolic
       FontBBox: -166, -239, 1114, 989
       FontFile3: true
      Encoding: WinAnsiEncoding
   XMP: <x:xmpmeta xmlns:x="adobe:ns:meta/" x:xmptk="XMP Core 5.1.2">
   <rdf:RDF xmlns:rdf="http://www.w3.org/1999/02/22-rdf-syntax-ns#">
      <rdf:Description rdf:about=""
            xmlns:xmp="http://ns.adobe.com/xap/1.0/">
         <xmp:CreateDate>2019-10-31T19:11:23+05:30</xmp:CreateDate>
         <xmp:CreatorTool>Elsevier</xmp:CreatorTool>
         <xmp:ModifyDate>2019-10-31T19:11:44+05:30</xmp:ModifyDate>
         <xmp:MetadataDate>2019-10-31T19:11:44+05:30</xmp:MetadataDate>
      </rdf:Description>
      <rdf:Description rdf:about=""
            xmlns:pdf="http://ns.adobe.com/pdf/1.3/">
         <pdf:Producer>Acrobat Distiller 10.1.16 (Windows)</pdf:Producer>
         <pdf:Keywords>Possible CMV disease,Quantitative PCR,Gastrointestinal tissue,Allo-SCT</pdf:Keywords>
      </rdf:Description>
      <rdf:Description rdf:about=""
            xmlns:dc="http://purl.org/dc/elements/1.1/">
         <dc:format>application/pdf</dc:format>
         <dc:identifier>doi:10.1016/j.bbmt.2019.07.016</dc:identifier>
         <dc:publisher>
            <rdf:Bag>
               <rdf:li>Elsevier Inc.</rdf:li>
            </rdf:Bag>
         </dc:publisher>
         <dc:description>
            <rdf:Alt>
               <rdf:li xml:lang="x-default">Biology of Blood and Marrow Transplantation, 25 (2019) 2281-2286. doi:10.1016/j.bbmt.2019.07.016</rdf:li>
            </rdf:Alt>
         </dc:description>
         <dc:subject>
            <rdf:Bag>
               <rdf:li>Possible CMV disease</rdf:li>
               <rdf:li>Quantitative PCR</rdf:li>
               <rdf:li>Gastrointestinal tissue</rdf:li>
               <rdf:li>Allo-SCT</rdf:li>
            </rdf:Bag>
         </dc:subject>
         <dc:title>
            <rdf:Alt>
               <rdf:li xml:lang="x-default">Quantitative PCR Is Faster, More Objective, and More Reliable Than Immunohistochemistry for the Diagnosis of Cytomegalovirus Gastrointestinal Disease in Allogeneic Stem Cell Transplantation</rdf:li>
            </rdf:Alt>
         </dc:title>
         <dc:creator>
            <rdf:Seq>
               <rdf:li>María Suárez-Lledó</rdf:li>
               <rdf:li>Maria Ángeles Marcos</rdf:li>
               <rdf:li>Miriam Cuatrecasas</rdf:li>
               <rdf:li>Josep Antoni Bombi</rdf:li>
               <rdf:li>Francesc Fernández-Avilés</rdf:li>
               <rdf:li>Laura Magnano</rdf:li>
               <rdf:li>Núria Martínez-Cibrián</rdf:li>
               <rdf:li>Noemi Llobet</rdf:li>
               <rdf:li>Laura Rosiñol</rdf:li>
               <rdf:li>Gonzalo Gutiérrez-García</rdf:li>
               <rdf:li>Sofía Jorge</rdf:li>
               <rdf:li>Carmen Martínez</rdf:li>
               <rdf:li>Montserrat Rovira</rdf:li>
               <rdf:li>Álvaro Urbano-Ispizua</rdf:li>
            </rdf:Seq>
         </dc:creator>
      </rdf:Description>
      <rdf:Description rdf:about=""
            xmlns:xmpMM="http://ns.adobe.com/xap/1.0/mm/">
         <xmpMM:DocumentID>uuid:fd8cfc10-4791-4a8b-8025-00abb91efa0c</xmpMM:DocumentID>
         <xmpMM:InstanceID>uuid:1c9230ab-7111-41c2-becd-d52a02dd7146</xmpMM:InstanceID>
      </rdf:Description>
      <rdf:Description rdf:about=""
            xmlns:prism_1_="http://prismstandard.org/namespaces/basic/3.0/">
         <prism_1_:aggregationType>journal</prism_1_:aggregationType>
         <prism_1_:copyright>© 2019 American Society for Transplantation and Cellular Therapy. Published by Elsevier Inc.</prism_1_:copyright>
         <prism_1_:publicationName>Biology of Blood and Marrow Transplantation</prism_1_:publicationName>
         <prism_1_:issn>1083-8791</prism_1_:issn>
         <prism_1_:volume>25</prism_1_:volume>
         <prism_1_:number>11</prism_1_:number>
         <prism_1_:doi>10.1016/j.bbmt.2019.07.016</prism_1_:doi>
         <prism_1_:url>https://doi.org/10.1016/j.bbmt.2019.07.016</prism_1_:url>
         <prism_1_:startingPage>2281</prism_1_:startingPage>
         <prism_1_:endingPage>2286</prism_1_:endingPage>
         <prism_1_:pageRange>2281-2286</prism_1_:pageRange>
         <prism_1_:coverDisplayDate>November 2019</prism_1_:coverDisplayDate>
      </rdf:Description>
      <rdf:Description rdf:about=""
            xmlns:pdfx="http://ns.adobe.com/pdfx/1.3/">
         <pdfx:ElsevierWebPDFSpecifications>6.5</pdfx:ElsevierWebPDFSpecifications>
         <pdfx:CrossmarkMajorVersionDate>2010-04-23</pdfx:CrossmarkMajorVersionDate>
         <pdfx:CrossmarkDomainExclusive>true</pdfx:CrossmarkDomainExclusive>
         <pdfx:doi>10.1016/j.bbmt.2019.07.016</pdfx:doi>
         <pdfx:robots>noindex</pdfx:robots>
         <pdfx:AuthoritativeDomain>
            <rdf:Bag>
               <rdf:li>sciencedirect.com</rdf:li>
               <rdf:li>elsevier.com</rdf:li>
            </rdf:Bag>
         </pdfx:AuthoritativeDomain>
         <pdfx:CrossMarkDomains>
            <rdf:Seq>
               <rdf:li>sciencedirect.com</rdf:li>
               <rdf:li>elsevier.com</rdf:li>
            </rdf:Seq>
         </pdfx:CrossMarkDomains>
      </rdf:Description>
      <rdf:Description rdf:about=""
            xmlns:jav="http://www.niso.org/schemas/jav/1.0/">
         <jav:journal_article_version>VoR</jav:journal_article_version>
      </rdf:Description>
      <rdf:Description rdf:about=""
            xmlns:crossmark_1_="http://crossref.org/crossmark/1.0/">
         <crossmark_1_:CrossmarkDomainExclusive>true</crossmark_1_:CrossmarkDomainExclusive>
         <crossmark_1_:MajorVersionDate>2010-04-23</crossmark_1_:MajorVersionDate>
         <crossmark_1_:DOI>10.1016/j.bbmt.2019.07.016</crossmark_1_:DOI>
         <crossmark_1_:CrossMarkDomains>
            <rdf:Seq>
               <rdf:li>sciencedirect.com</rdf:li>
               <rdf:li>elsevier.com</rdf:li>
            </rdf:Seq>
         </crossmark_1_:CrossMarkDomains>
      </rdf:Description>
      <rdf:Description rdf:about=""
            xmlns:xmpRights="http://ns.adobe.com/xap/1.0/rights/">
         <xmpRights:Marked>True</xmpRights:Marked>
      </rdf:Description>
   </rdf:RDF>
</x:xmpmeta>
   Pages: 
    Page: 
     Label: 2281
     Sequence: 1
     Annotations: 
      Annotation: 
       Subtype: Link
       Rect: 500, 608, 529, 637
      Annotation: 
       Subtype: Link
       Rect: 143, 570, 148, 581
       Destination: 225
      Annotation: 
       Subtype: Link
       Rect: 150, 566, 154, 576
       Destination: 225
      Annotation: 
       Subtype: Link
       Rect: 267, 570, 272, 581
       Destination: 225
      Annotation: 
       Subtype: Link
       Rect: 274, 570, 278, 581
       Destination: 225
      Annotation: 
       Subtype: Link
       Rect: 280, 570, 285, 581
       Destination: 225
      Annotation: 
       Subtype: Link
       Rect: 384, 570, 388, 581
       Destination: 225
      Annotation: 
       Subtype: Link
       Rect: 390, 570, 395, 581
       Destination: 225
      Annotation: 
       Subtype: Link
       Rect: 494, 570, 498, 581
       Destination: 225
      Annotation: 
       Subtype: Link
       Rect: 500, 570, 505, 581
       Destination: 225
      Annotation: 
       Subtype: Link
       Rect: 178, 557, 182, 568
       Destination: 225
      Annotation: 
       Subtype: Link
       Rect: 184, 557, 189, 568
       Destination: 225
      Annotation: 
       Subtype: Link
       Rect: 190, 557, 195, 568
       Destination: 225
      Annotation: 
       Subtype: Link
       Rect: 274, 557, 279, 568
       Destination: 225
      Annotation: 
       Subtype: Link
       Rect: 395, 557, 400, 568
       Destination: 225
      Annotation: 
       Subtype: Link
       Rect: 469, 557, 473, 568
       Destination: 225
      Annotation: 
       Subtype: Link
       Rect: 115, 544, 120, 555
       Destination: 225
      Annotation: 
       Subtype: Link
       Rect: 121, 544, 126, 555
       Destination: 225
      Annotation: 
       Subtype: Link
       Rect: 128, 544, 132, 555
       Destination: 225
      Annotation: 
       Subtype: Link
       Rect: 259, 544, 264, 555
       Destination: 225
      Annotation: 
       Subtype: Link
       Rect: 266, 544, 270, 555
       Destination: 225
      Annotation: 
       Subtype: Link
       Rect: 326, 544, 330, 555
       Destination: 225
      Annotation: 
       Subtype: Link
       Rect: 419, 544, 423, 555
       Destination: 225
      Annotation: 
       Subtype: Link
       Rect: 425, 544, 429, 555
       Destination: 225
      Annotation: 
       Subtype: Link
       Rect: 431, 544, 436, 555
       Destination: 225
      Annotation: 
       Subtype: Link
       Rect: 138, 532, 142, 542
       Destination: 225
      Annotation: 
       Subtype: Link
       Rect: 144, 532, 149, 542
       Destination: 225
      Annotation: 
       Subtype: Link
       Rect: 151, 532, 155, 542
       Destination: 225
      Annotation: 
       Subtype: Link
       Rect: 268, 532, 272, 542
       Destination: 225
      Annotation: 
       Subtype: Link
       Rect: 274, 532, 279, 542
       Destination: 225
      Annotation: 
       Subtype: Link
       Rect: 280, 532, 285, 542
       Destination: 225
      Annotation: 
       Subtype: Link
       Rect: 494, 211, 504, 219
       Destination: 44
      Annotation: 
       Subtype: Link
       Rect: 337, 169, 355, 177
       Destination: 44
      Annotation: 
       Subtype: Link
       Rect: 107, 95, 164, 102
      Annotation: 
       Subtype: Link
       Rect: 51, 64, 176, 71
      Annotation: 
       Subtype: Link
       Rect: 214, 760, 346, 767
      Annotation: 
       Subtype: Link
       Rect: 351, 760, 366, 767
      Annotation: 
       Subtype: Link
       Rect: 287, 679, 354, 687
    Page: 
     Label: 2282
     Sequence: 2
     Annotations: 
      Annotation: 
       Subtype: Link
       Rect: 93, 725, 110, 733
       Destination: 44
      Annotation: 
       Subtype: Link
       Rect: 121, 704, 147, 712
       Destination: 44
      Annotation: 
       Subtype: Link
       Rect: 262, 662, 277, 670
       Destination: 44
      Annotation: 
       Subtype: Link
       Rect: 150, 599, 164, 607
       Destination: 44
      Annotation: 
       Subtype: Link
       Rect: 265, 547, 289, 555
       Destination: 44
      Annotation: 
       Subtype: Link
       Rect: 200, 484, 227, 492
       Destination: 44
      Annotation: 
       Subtype: Link
       Rect: 64, 369, 78, 377
       Destination: 44
      Annotation: 
       Subtype: Link
       Rect: 217, 348, 258, 356
       Destination: 44
      Annotation: 
       Subtype: Link
       Rect: 429, 607, 441, 613
       Destination: 44
      Annotation: 
       Subtype: Link
       Rect: 372, 166, 384, 172
       Destination: 44
    Page: 
     Label: 2283
     Sequence: 3
     Annotations: 
      Annotation: 
       Subtype: Link
       Rect: 244, 567, 273, 575
       Destination: 14
      Annotation: 
       Subtype: Link
       Rect: 86, 546, 112, 554
       Destination: 32
      Annotation: 
       Subtype: Link
       Rect: 514, 704, 529, 712
       Destination: 44
      Annotation: 
       Subtype: Link
       Rect: 477, 693, 488, 701
       Destination: 44
      Annotation: 
       Subtype: Link
       Rect: 359, 599, 386, 607
       Destination: 32
      Annotation: 
       Subtype: Link
       Rect: 302, 380, 316, 388
       Destination: 44
    Page: 
     Label: 2284
     Sequence: 4
     Annotations: 
      Annotation: 
       Subtype: Link
       Rect: 318, 610, 344, 618
       Destination: 36
    Page: 
     Label: 2285
     Sequence: 5
     Annotations: 
      Annotation: 
       Subtype: Link
       Rect: 136, 475, 151, 483
       Destination: 44
      Annotation: 
       Subtype: Link
       Rect: 158, 370, 173, 378
       Destination: 44
      Annotation: 
       Subtype: Link
       Rect: 199, 56, 225, 64
       Destination: 36
      Annotation: 
       Subtype: Link
       Rect: 518, 568, 521, 575
       Destination: 36
      Annotation: 
       Subtype: Link
       Rect: 520, 557, 522, 564
       Destination: 36
    Page: 
     Label: 2286
     Sequence: 6
     Annotations: 
      Annotation: 
       Subtype: Link
       Rect: 77, 717, 291, 723
      Annotation: 
       Subtype: Link
       Rect: 77, 709, 229, 715
      Annotation: 
       Subtype: Link
       Rect: 77, 701, 291, 707
      Annotation: 
       Subtype: Link
       Rect: 77, 693, 246, 699
      Annotation: 
       Subtype: Link
       Rect: 77, 685, 291, 691
      Annotation: 
       Subtype: Link
       Rect: 77, 677, 291, 683
      Annotation: 
       Subtype: Link
       Rect: 77, 669, 291, 675
      Annotation: 
       Subtype: Link
       Rect: 77, 661, 291, 667
      Annotation: 
       Subtype: Link
       Rect: 77, 653, 229, 659
      Annotation: 
       Subtype: Link
       Rect: 77, 645, 291, 651
      Annotation: 
       Subtype: Link
       Rect: 77, 637, 291, 643
      Annotation: 
       Subtype: Link
       Rect: 77, 629, 242, 635
      Annotation: 
       Subtype: Link
       Rect: 77, 621, 291, 627
      Annotation: 
       Subtype: Link
       Rect: 77, 613, 291, 619
      Annotation: 
       Subtype: Link
       Rect: 77, 605, 291, 611
      Annotation: 
       Subtype: Link
       Rect: 77, 597, 243, 604
      Annotation: 
       Subtype: Link
       Rect: 77, 589, 291, 596
      Annotation: 
       Subtype: Link
       Rect: 77, 581, 291, 588
      Annotation: 
       Subtype: Link
       Rect: 77, 573, 291, 580
      Annotation: 
       Subtype: Link
       Rect: 77, 565, 282, 572
      Annotation: 
       Subtype: Link
       Rect: 77, 557, 291, 564
      Annotation: 
       Subtype: Link
       Rect: 77, 549, 291, 556
      Annotation: 
       Subtype: Link
       Rect: 77, 541, 291, 548
      Annotation: 
       Subtype: Link
       Rect: 77, 533, 290, 540
      Annotation: 
       Subtype: Link
       Rect: 76, 525, 291, 532
      Annotation: 
       Subtype: Link
       Rect: 76, 517, 274, 524
      Annotation: 
       Subtype: Link
       Rect: 77, 509, 291, 516
      Annotation: 
       Subtype: Link
       Rect: 77, 501, 291, 508
      Annotation: 
       Subtype: Link
       Rect: 77, 494, 291, 500
      Annotation: 
       Subtype: Link
       Rect: 77, 486, 139, 492
      Annotation: 
       Subtype: Link
       Rect: 77, 478, 291, 484
      Annotation: 
       Subtype: Link
       Rect: 77, 470, 291, 476
      Annotation: 
       Subtype: Link
       Rect: 77, 462, 213, 468
      Annotation: 
       Subtype: Link
       Rect: 77, 454, 291, 460
      Annotation: 
       Subtype: Link
       Rect: 77, 446, 291, 452
      Annotation: 
       Subtype: Link
       Rect: 77, 438, 171, 444
      Annotation: 
       Subtype: Link
       Rect: 77, 430, 291, 436
      Annotation: 
       Subtype: Link
       Rect: 77, 422, 272, 428
      Annotation: 
       Subtype: Link
       Rect: 328, 725, 542, 732
      Annotation: 
       Subtype: Link
       Rect: 328, 717, 542, 724
      Annotation: 
       Subtype: Link
       Rect: 328, 709, 542, 716
      Annotation: 
       Subtype: Link
       Rect: 328, 701, 431, 708
      Annotation: 
       Subtype: Link
       Rect: 328, 693, 542, 700
      Annotation: 
       Subtype: Link
       Rect: 328, 685, 542, 692
      Annotation: 
       Subtype: Link
       Rect: 328, 677, 468, 684
      Annotation: 
       Subtype: Link
       Rect: 328, 669, 542, 676
      Annotation: 
       Subtype: Link
       Rect: 328, 662, 542, 668
      Annotation: 
       Subtype: Link
       Rect: 328, 654, 481, 660
      Annotation: 
       Subtype: Link
       Rect: 328, 646, 542, 652
      Annotation: 
       Subtype: Link
       Rect: 328, 638, 542, 644
      Annotation: 
       Subtype: Link
       Rect: 328, 630, 542, 636
      Annotation: 
       Subtype: Link
       Rect: 328, 622, 447, 628
      Annotation: 
       Subtype: Link
       Rect: 328, 614, 542, 620
      Annotation: 
       Subtype: Link
       Rect: 328, 606, 542, 612
      Annotation: 
       Subtype: Link
       Rect: 328, 598, 394, 604
      Annotation: 
       Subtype: Link
       Rect: 328, 590, 338, 596
      Annotation: 
       Subtype: Link
       Rect: 342, 590, 508, 596
      Annotation: 
       Subtype: Link
       Rect: 511, 590, 542, 596
      Annotation: 
       Subtype: Link
       Rect: 328, 582, 542, 588
      Annotation: 
       Subtype: Link
       Rect: 328, 574, 542, 580
      Annotation: 
       Subtype: Link
       Rect: 328, 566, 502, 572
      Annotation: 
       Subtype: Link
       Rect: 328, 558, 451, 564
      Annotation: 
       Subtype: Link
       Rect: 454, 558, 542, 564
      Annotation: 
       Subtype: Link
       Rect: 328, 550, 542, 556
      Annotation: 
       Subtype: Link
       Rect: 328, 542, 542, 548
      Annotation: 
       Subtype: Link
       Rect: 328, 534, 365, 540
      Annotation: 
       Subtype: Link
       Rect: 328, 526, 542, 532
      Annotation: 
       Subtype: Link
       Rect: 328, 518, 542, 524
      Annotation: 
       Subtype: Link
       Rect: 328, 510, 542, 516
      Annotation: 
       Subtype: Link
       Rect: 328, 502, 463, 508
      Annotation: 
       Subtype: Link
       Rect: 328, 494, 542, 500
      Annotation: 
       Subtype: Link
       Rect: 328, 486, 542, 493
      Annotation: 
       Subtype: Link
       Rect: 328, 478, 530, 485
      Annotation: 
       Subtype: Link
       Rect: 328, 470, 542, 477
      Annotation: 
       Subtype: Link
       Rect: 328, 462, 542, 469
      Annotation: 
       Subtype: Link
       Rect: 328, 454, 511, 461
      Annotation: 
       Subtype: Link
       Rect: 328, 446, 542, 453
      Annotation: 
       Subtype: Link
       Rect: 328, 438, 542, 445
      Annotation: 
       Subtype: Link
       Rect: 328, 430, 542, 437
      Annotation: 
       Subtype: Link
       Rect: 328, 422, 444, 429
  Checksum: acc9b433
   Type: CRC32
  Checksum: 05ff25823ecedd877a6c7fb0b3ca6043
   Type: MD5
  Checksum: d98fcf4ffda02887cea34d1562d46fd63463b237
   Type: SHA-1