03235336e9f029348e5908c3caa62739  236896.pdf
f8157d167b4c5db48820dc143c6a2645f12d333a  236896.pdf
852103097b5f34ceeaf276535fb7632bf0c2e2d91825a8e633788d35b6f8c091  236896.pdf

Title:          Epigenetic silencing of TGFBI confers resistance to trastuzumab in human breast cancer
Subject:        Breast Cancer Research, 2019, doi:10.1186/s13058-019-1160-x
Keywords:       HER2+ breast cancer,Trastuzumab resistance,DNA methylation,TGFBI
Author:         Sònia Palomeras
Creator:        Arbortext Advanced Print Publisher 9.1.440/W Unicode
Producer:       Acrobat Distiller 10.1.5 (Windows); modified using iText® 5.3.5 ©2000-2012 1T3XT BVBA (AGPL-version)
CreationDate:   Wed Jul  3 02:00:38 2019 CEST
ModDate:        Fri Jul  5 14:43:22 2019 CEST
Tagged:         no
UserProperties: no
Suspects:       no
Form:           none
JavaScript:     no
Pages:          16
Encrypted:      no
Page size:      595.276 x 790.866 pts
Page rot:       0
File size:      2361067 bytes
Optimized:      no
PDF version:    1.4


name                                 type              encoding         emb sub uni object ID
------------------------------------ ----------------- ---------------- --- --- --- ---------
AONBEN+YqqmcsAdvTTaf7f9f4f.B         Type 1C           WinAnsi          yes yes no       8  0
AONBJM+XkvhgsAdvTTe45e47d2           Type 1C           WinAnsi          yes yes no       9  0
AONBJN+QphwmhAdvTT7329fd89.I         Type 1C           WinAnsi          yes yes no      10  0
AONBJO+HcbtckAdvTTb5929f4c           Type 1C           WinAnsi          yes yes no     127  0
AONBJP+PfrjtlAdvTTb5929f4c+20        Type 1C           Custom           yes yes yes    144  0
AONBKA+SspyffAdvTT99c4c969           Type 1C           WinAnsi          yes yes no      14  0
MyriadPro-Regular                    Type 1            Custom           yes no  no      12  0
AONBKB+VrpvfbAdvTT1b53b5fb.I         Type 1C           WinAnsi          yes yes no     145  0
AONCGA+BbbgwyAdvTT86d47313+20        Type 1C           Custom           yes yes yes     11  0
AONCHA+JhvsygAdvTT8861b38f.I         Type 1C           WinAnsi          yes yes no      13  0
AONCFP+KjsrddAdvTT86d47313           Type 1C           WinAnsi          yes yes no      15  0
AONCHB+SxlwnjAdvTT86d47313+03        Type 1C           Custom           yes yes yes     16  0
AONCJB+KpqcfnAdvTT99c4c969+20        Type 1C           Custom           yes yes yes     49  0
AONCMB+QxddryAdvTT86d47313+21        Type 1C           WinAnsi          yes yes no      66  0
AONCMC+RtgjxbAdvTT86d47313+22        Type 1C           Custom           yes yes yes     67  0
AONCND+NhrqvfAdvTT8861b38f.I+03      Type 1C           Custom           yes yes yes     84  0
AONCOE+MxylxyAdvTT83913201.I         Type 1C           WinAnsi          yes yes no      85  0
AONGKA+MskgmjAdvTTb5929f4c+22        Type 1C           Custom           yes yes yes    126  0
AONGKB+RrfktyAdvTTb5929f4c+03        Type 1C           Custom           yes yes yes    128  0
AONGHO+TghlrxHelvetica-Bold          Type 1C           WinAnsi          yes yes no     129  0
AONGJP+DqqhvgAdvTT1b53b5fb.I+03      Type 1C           Custom           yes yes yes    130  0
AOODGD+XddbnsAdvTTaf7f9f4f.B+20      Type 1C           WinAnsi          yes yes no     293  0


Jhove (Rel. 1.22.1, 2019-04-17)
 Date: 2021-02-24 02:25:27 CET
 RepresentationInformation: 236896.pdf
  ReportingModule: PDF-hul, Rel. 1.12.1 (2019-04-17)
  LastModified: 2021-02-20 11:31:23 CET
  Size: 2361067
  Format: PDF
  Version: 1.4
  Status: Well-Formed, but not valid
  SignatureMatches:
   PDF-hul
  ID: PDF-HUL-122
  ErrorMessage: edu.harvard.hul.ois.jhove.module.pdf.PdfInvalidException: Invalid indirect destination - referenced object 'link_CR1' cannot be found
   Offset: 2115031
  ID: PDF-HUL-122
  ErrorMessage: edu.harvard.hul.ois.jhove.module.pdf.PdfInvalidException: Invalid indirect destination - referenced object 'link_CR2' cannot be found
   Offset: 2115031
  ID: PDF-HUL-122
  ErrorMessage: edu.harvard.hul.ois.jhove.module.pdf.PdfInvalidException: Invalid indirect destination - referenced object 'link_CR3' cannot be found
   Offset: 2115031
  ID: PDF-HUL-122
  ErrorMessage: edu.harvard.hul.ois.jhove.module.pdf.PdfInvalidException: Invalid indirect destination - referenced object 'link_CR4' cannot be found
   Offset: 2115031
  ID: PDF-HUL-122
  ErrorMessage: edu.harvard.hul.ois.jhove.module.pdf.PdfInvalidException: Invalid indirect destination - referenced object 'link_CR5' cannot be found
   Offset: 2115031
  ID: PDF-HUL-122
  ErrorMessage: edu.harvard.hul.ois.jhove.module.pdf.PdfInvalidException: Invalid indirect destination - referenced object 'link_CR6' cannot be found
   Offset: 2115031
  ID: PDF-HUL-122
  ErrorMessage: edu.harvard.hul.ois.jhove.module.pdf.PdfInvalidException: Invalid indirect destination - referenced object 'link_CR10' cannot be found
   Offset: 2115031
  ID: PDF-HUL-122
  ErrorMessage: edu.harvard.hul.ois.jhove.module.pdf.PdfInvalidException: Invalid indirect destination - referenced object 'link_CR11' cannot be found
   Offset: 2115031
  ID: PDF-HUL-122
  ErrorMessage: edu.harvard.hul.ois.jhove.module.pdf.PdfInvalidException: Invalid indirect destination - referenced object 'link_CR12' cannot be found
   Offset: 2115031
  ID: PDF-HUL-122
  ErrorMessage: edu.harvard.hul.ois.jhove.module.pdf.PdfInvalidException: Invalid indirect destination - referenced object 'link_CR13' cannot be found
   Offset: 2115031
  ID: PDF-HUL-122
  ErrorMessage: edu.harvard.hul.ois.jhove.module.pdf.PdfInvalidException: Invalid indirect destination - referenced object 'link_CR14' cannot be found
   Offset: 2115031
  ID: PDF-HUL-122
  ErrorMessage: edu.harvard.hul.ois.jhove.module.pdf.PdfInvalidException: Invalid indirect destination - referenced object 'link_CR15' cannot be found
   Offset: 2115031
  ID: PDF-HUL-122
  ErrorMessage: edu.harvard.hul.ois.jhove.module.pdf.PdfInvalidException: Invalid indirect destination - referenced object 'link_CR16' cannot be found
   Offset: 2115031
  ID: PDF-HUL-122
  ErrorMessage: edu.harvard.hul.ois.jhove.module.pdf.PdfInvalidException: Invalid indirect destination - referenced object 'link_CR17' cannot be found
   Offset: 2115031
  ID: PDF-HUL-122
  ErrorMessage: edu.harvard.hul.ois.jhove.module.pdf.PdfInvalidException: Invalid indirect destination - referenced object 'link_CR18' cannot be found
   Offset: 2115031
  ID: PDF-HUL-122
  ErrorMessage: edu.harvard.hul.ois.jhove.module.pdf.PdfInvalidException: Invalid indirect destination - referenced object 'link_CR19' cannot be found
   Offset: 2115031
  ID: PDF-HUL-122
  ErrorMessage: edu.harvard.hul.ois.jhove.module.pdf.PdfInvalidException: Invalid indirect destination - referenced object 'link_CR20' cannot be found
   Offset: 2115031
  ID: PDF-HUL-122
  ErrorMessage: edu.harvard.hul.ois.jhove.module.pdf.PdfInvalidException: Invalid indirect destination - referenced object 'link_CR21' cannot be found
   Offset: 2115031
  ID: PDF-HUL-122
  ErrorMessage: edu.harvard.hul.ois.jhove.module.pdf.PdfInvalidException: Invalid indirect destination - referenced object 'link_CR22' cannot be found
   Offset: 2115031
  ID: PDF-HUL-122
  ErrorMessage: edu.harvard.hul.ois.jhove.module.pdf.PdfInvalidException: Invalid indirect destination - referenced object 'link_CR16' cannot be found
   Offset: 2115031
  ID: PDF-HUL-122
  ErrorMessage: edu.harvard.hul.ois.jhove.module.pdf.PdfInvalidException: Invalid indirect destination - referenced object 'link_CR16' cannot be found
   Offset: 2115031
  ID: PDF-HUL-122
  ErrorMessage: edu.harvard.hul.ois.jhove.module.pdf.PdfInvalidException: Invalid indirect destination - referenced object 'link_CR20' cannot be found
   Offset: 2115031
  ID: PDF-HUL-122
  ErrorMessage: edu.harvard.hul.ois.jhove.module.pdf.PdfInvalidException: Invalid indirect destination - referenced object 'link_CR23' cannot be found
   Offset: 2115031
  ID: PDF-HUL-122
  ErrorMessage: edu.harvard.hul.ois.jhove.module.pdf.PdfInvalidException: Invalid indirect destination - referenced object 'link_CR24' cannot be found
   Offset: 2115031
  ID: PDF-HUL-122
  ErrorMessage: edu.harvard.hul.ois.jhove.module.pdf.PdfInvalidException: Invalid indirect destination - referenced object 'link_CR25' cannot be found
   Offset: 2115031
  ID: PDF-HUL-122
  ErrorMessage: edu.harvard.hul.ois.jhove.module.pdf.PdfInvalidException: Invalid indirect destination - referenced object 'link_CR27' cannot be found
   Offset: 2115031
  ID: PDF-HUL-122
  ErrorMessage: edu.harvard.hul.ois.jhove.module.pdf.PdfInvalidException: Invalid indirect destination - referenced object 'link_CR28' cannot be found
   Offset: 2115031
  ID: PDF-HUL-122
  ErrorMessage: edu.harvard.hul.ois.jhove.module.pdf.PdfInvalidException: Invalid indirect destination - referenced object 'link_CR29' cannot be found
   Offset: 2115031
  ID: PDF-HUL-122
  ErrorMessage: edu.harvard.hul.ois.jhove.module.pdf.PdfInvalidException: Invalid indirect destination - referenced object 'link_CR30' cannot be found
   Offset: 2115031
  ID: PDF-HUL-122
  ErrorMessage: edu.harvard.hul.ois.jhove.module.pdf.PdfInvalidException: Invalid indirect destination - referenced object 'link_CR32' cannot be found
   Offset: 2115031
  ID: PDF-HUL-122
  ErrorMessage: edu.harvard.hul.ois.jhove.module.pdf.PdfInvalidException: Invalid indirect destination - referenced object 'link_CR22' cannot be found
   Offset: 2115031
  ID: PDF-HUL-122
  ErrorMessage: edu.harvard.hul.ois.jhove.module.pdf.PdfInvalidException: Invalid indirect destination - referenced object 'link_CR22' cannot be found
   Offset: 2115031
  ID: PDF-HUL-122
  ErrorMessage: edu.harvard.hul.ois.jhove.module.pdf.PdfInvalidException: Invalid indirect destination - referenced object 'link_CR33' cannot be found
   Offset: 2115031
  ID: PDF-HUL-122
  ErrorMessage: edu.harvard.hul.ois.jhove.module.pdf.PdfInvalidException: Invalid indirect destination - referenced object 'link_CR34' cannot be found
   Offset: 2115031
  ID: PDF-HUL-122
  ErrorMessage: edu.harvard.hul.ois.jhove.module.pdf.PdfInvalidException: Invalid indirect destination - referenced object 'link_CR34' cannot be found
   Offset: 2115031
  ID: PDF-HUL-122
  ErrorMessage: edu.harvard.hul.ois.jhove.module.pdf.PdfInvalidException: Invalid indirect destination - referenced object 'link_CR16' cannot be found
   Offset: 2115031
  ID: PDF-HUL-122
  ErrorMessage: edu.harvard.hul.ois.jhove.module.pdf.PdfInvalidException: Invalid indirect destination - referenced object 'link_CR17' cannot be found
   Offset: 2115031
  ID: PDF-HUL-122
  ErrorMessage: edu.harvard.hul.ois.jhove.module.pdf.PdfInvalidException: Invalid indirect destination - referenced object 'link_CR17' cannot be found
   Offset: 2115031
  ID: PDF-HUL-122
  ErrorMessage: edu.harvard.hul.ois.jhove.module.pdf.PdfInvalidException: Invalid indirect destination - referenced object 'link_CR35' cannot be found
   Offset: 2115031
  ID: PDF-HUL-122
  ErrorMessage: edu.harvard.hul.ois.jhove.module.pdf.PdfInvalidException: Invalid indirect destination - referenced object 'link_CR36' cannot be found
   Offset: 2115031
  ID: PDF-HUL-122
  ErrorMessage: edu.harvard.hul.ois.jhove.module.pdf.PdfInvalidException: Invalid indirect destination - referenced object 'link_CR37' cannot be found
   Offset: 2115031
  ID: PDF-HUL-122
  ErrorMessage: edu.harvard.hul.ois.jhove.module.pdf.PdfInvalidException: Invalid indirect destination - referenced object 'link_CR38' cannot be found
   Offset: 2115031
  ID: PDF-HUL-122
  ErrorMessage: edu.harvard.hul.ois.jhove.module.pdf.PdfInvalidException: Invalid indirect destination - referenced object 'link_CR39' cannot be found
   Offset: 2115031
  ID: PDF-HUL-122
  ErrorMessage: edu.harvard.hul.ois.jhove.module.pdf.PdfInvalidException: Invalid indirect destination - referenced object 'link_CR22' cannot be found
   Offset: 2115031
  ID: PDF-HUL-122
  ErrorMessage: edu.harvard.hul.ois.jhove.module.pdf.PdfInvalidException: Invalid indirect destination - referenced object 'link_CR30' cannot be found
   Offset: 2115031
  ID: PDF-HUL-122
  ErrorMessage: edu.harvard.hul.ois.jhove.module.pdf.PdfInvalidException: Invalid indirect destination - referenced object 'link_CR32' cannot be found
   Offset: 2115031
  ID: PDF-HUL-122
  ErrorMessage: edu.harvard.hul.ois.jhove.module.pdf.PdfInvalidException: Invalid indirect destination - referenced object 'link_CR25' cannot be found
   Offset: 2115031
  ID: PDF-HUL-122
  ErrorMessage: edu.harvard.hul.ois.jhove.module.pdf.PdfInvalidException: Invalid indirect destination - referenced object 'link_CR40' cannot be found
   Offset: 2115031
  ID: PDF-HUL-122
  ErrorMessage: edu.harvard.hul.ois.jhove.module.pdf.PdfInvalidException: Invalid indirect destination - referenced object 'link_CR42' cannot be found
   Offset: 2115031
  ID: PDF-HUL-122
  ErrorMessage: edu.harvard.hul.ois.jhove.module.pdf.PdfInvalidException: Invalid indirect destination - referenced object 'link_CR43' cannot be found
   Offset: 2115031
  ID: PDF-HUL-122
  ErrorMessage: edu.harvard.hul.ois.jhove.module.pdf.PdfInvalidException: Invalid indirect destination - referenced object 'link_CR46' cannot be found
   Offset: 2115031
  ID: PDF-HUL-122
  ErrorMessage: edu.harvard.hul.ois.jhove.module.pdf.PdfInvalidException: Invalid indirect destination - referenced object 'link_CR22' cannot be found
   Offset: 2115031
  ID: PDF-HUL-122
  ErrorMessage: edu.harvard.hul.ois.jhove.module.pdf.PdfInvalidException: Invalid indirect destination - referenced object 'link_CR16' cannot be found
   Offset: 2115031
  ID: PDF-HUL-122
  ErrorMessage: edu.harvard.hul.ois.jhove.module.pdf.PdfInvalidException: Invalid indirect destination - referenced object 'link_CR47' cannot be found
   Offset: 2115031
  ID: PDF-HUL-122
  ErrorMessage: edu.harvard.hul.ois.jhove.module.pdf.PdfInvalidException: Invalid indirect destination - referenced object 'link_CR48' cannot be found
   Offset: 2115031
  ID: PDF-HUL-122
  ErrorMessage: edu.harvard.hul.ois.jhove.module.pdf.PdfInvalidException: Invalid indirect destination - referenced object 'link_CR49' cannot be found
   Offset: 2115031
  ID: PDF-HUL-122
  ErrorMessage: edu.harvard.hul.ois.jhove.module.pdf.PdfInvalidException: Invalid indirect destination - referenced object 'link_CR50' cannot be found
   Offset: 2115031
  ID: PDF-HUL-122
  ErrorMessage: edu.harvard.hul.ois.jhove.module.pdf.PdfInvalidException: Invalid indirect destination - referenced object 'link_CR22' cannot be found
   Offset: 2115031
  ID: PDF-HUL-122
  ErrorMessage: edu.harvard.hul.ois.jhove.module.pdf.PdfInvalidException: Invalid indirect destination - referenced object 'link_CR31' cannot be found
   Offset: 2115031
  ID: PDF-HUL-122
  ErrorMessage: edu.harvard.hul.ois.jhove.module.pdf.PdfInvalidException: Invalid indirect destination - referenced object 'link_CR51' cannot be found
   Offset: 2115031
  ID: PDF-HUL-122
  ErrorMessage: edu.harvard.hul.ois.jhove.module.pdf.PdfInvalidException: Invalid indirect destination - referenced object 'link_CR53' cannot be found
   Offset: 2115031
  ID: PDF-HUL-122
  ErrorMessage: edu.harvard.hul.ois.jhove.module.pdf.PdfInvalidException: Invalid indirect destination - referenced object 'link_CR54' cannot be found
   Offset: 2115031
  ID: PDF-HUL-122
  ErrorMessage: edu.harvard.hul.ois.jhove.module.pdf.PdfInvalidException: Invalid indirect destination - referenced object 'link_CR55' cannot be found
   Offset: 2115031
  ID: PDF-HUL-122
  ErrorMessage: edu.harvard.hul.ois.jhove.module.pdf.PdfInvalidException: Invalid indirect destination - referenced object 'link_CR56' cannot be found
   Offset: 2115031
  ID: PDF-HUL-122
  ErrorMessage: edu.harvard.hul.ois.jhove.module.pdf.PdfInvalidException: Invalid indirect destination - referenced object 'link_CR16' cannot be found
   Offset: 2115031
  ID: PDF-HUL-122
  ErrorMessage: edu.harvard.hul.ois.jhove.module.pdf.PdfInvalidException: Invalid indirect destination - referenced object 'link_CR57' cannot be found
   Offset: 2115031
  ID: PDF-HUL-122
  ErrorMessage: edu.harvard.hul.ois.jhove.module.pdf.PdfInvalidException: Invalid indirect destination - referenced object 'link_CR41' cannot be found
   Offset: 2115031
  ID: PDF-HUL-122
  ErrorMessage: edu.harvard.hul.ois.jhove.module.pdf.PdfInvalidException: Invalid indirect destination - referenced object 'link_CR40' cannot be found
   Offset: 2115031
  ID: PDF-HUL-122
  ErrorMessage: edu.harvard.hul.ois.jhove.module.pdf.PdfInvalidException: Invalid indirect destination - referenced object 'link_CR58' cannot be found
   Offset: 2115031
  ID: PDF-HUL-122
  ErrorMessage: edu.harvard.hul.ois.jhove.module.pdf.PdfInvalidException: Invalid indirect destination - referenced object 'link_CR59' cannot be found
   Offset: 2115031
  MIMEtype: application/pdf
  PDFMetadata: 
   Objects: 594
   FreeObjects: 1
   IncrementalUpdates: 0
   DocumentCatalog: 
    PageLayout: SinglePage
    PageMode: UseOutlines
    Language: EN
    Outlines: 
     Item: 
      Title: Abstract
      Destination: edu.harvard.hul.ois.jhove.module.pdf.PdfSimpleObject@11758f2a
      Children: 
       Item: 
        Title: Background
        Destination: edu.harvard.hul.ois.jhove.module.pdf.PdfSimpleObject@e720b71
       Item: 
        Title: Methods
        Destination: edu.harvard.hul.ois.jhove.module.pdf.PdfSimpleObject@1b26f7b2
       Item: 
        Title: Results
        Destination: edu.harvard.hul.ois.jhove.module.pdf.PdfSimpleObject@491cc5c9
       Item: 
        Title: Conclusions
        Destination: edu.harvard.hul.ois.jhove.module.pdf.PdfSimpleObject@74ad1f1f
     Item: 
      Title: Background
      Destination: edu.harvard.hul.ois.jhove.module.pdf.PdfSimpleObject@6a1aab78
     Item: 
      Title: Methods
      Destination: edu.harvard.hul.ois.jhove.module.pdf.PdfSimpleObject@462d5aee
      Children: 
       Item: 
        Title: Cell culture
        Destination: edu.harvard.hul.ois.jhove.module.pdf.PdfSimpleObject@69b0fd6f
       Item: 
        Title: Patients and tissue samples
        Destination: edu.harvard.hul.ois.jhove.module.pdf.PdfSimpleObject@757942a1
       Item: 
        Title: 5-Aza-2′-deoxycytidine treatment
        Destination: edu.harvard.hul.ois.jhove.module.pdf.PdfSimpleObject@4a87761d
       Item: 
        Title: DNA and RNA isolation procedures
        Destination: edu.harvard.hul.ois.jhove.module.pdf.PdfSimpleObject@66d1af89
       Item: 
        Title: DNA methylation array
        Destination: edu.harvard.hul.ois.jhove.module.pdf.PdfSimpleObject@8646db9
       Item: 
        Title: RNA sequencing
        Destination: edu.harvard.hul.ois.jhove.module.pdf.PdfSimpleObject@37374a5e
       Item: 
        Title: Bisulfite pyrosequencing
        Destination: edu.harvard.hul.ois.jhove.module.pdf.PdfSimpleObject@4671e53b
       Item: 
        Title: Methylation-specific PCR (MSP)
        Destination: edu.harvard.hul.ois.jhove.module.pdf.PdfSimpleObject@2db7a79b
       Item: 
        Title: Gene expression analysis (qRT-PCR)
        Destination: edu.harvard.hul.ois.jhove.module.pdf.PdfSimpleObject@6950e31
       Item: 
        Title: Short hairpin interference and ectopic expression assays
        Destination: edu.harvard.hul.ois.jhove.module.pdf.PdfSimpleObject@b7dd107
       Item: 
        Title: Cell viability assays
        Destination: edu.harvard.hul.ois.jhove.module.pdf.PdfSimpleObject@42eca56e
       Item: 
        Title: Western blot analysis
        Destination: edu.harvard.hul.ois.jhove.module.pdf.PdfSimpleObject@52f759d7
       Item: 
        Title: Statistical analysis
        Destination: edu.harvard.hul.ois.jhove.module.pdf.PdfSimpleObject@7cbd213e
     Item: 
      Title: Results
      Destination: edu.harvard.hul.ois.jhove.module.pdf.PdfSimpleObject@192d3247
      Children: 
       Item: 
        Title: Genome-wide DNA methylation analysis in trastuzumab-sensitive (SK) and trastuzumab-resistant (SKTR) breast cancer models
        Destination: edu.harvard.hul.ois.jhove.module.pdf.PdfSimpleObject@3ecd23d9
       Item: 
        Title: Epigenetic silencing of TGFBI, CXCL2, and SLC38A1 in trastuzumab-resistant cells (SKTR)
        Destination: edu.harvard.hul.ois.jhove.module.pdf.PdfSimpleObject@569cfc36
       Item: 
        Title: The role of TGFBI expression in trastuzumab resistance cells (SKTR)
        Destination: edu.harvard.hul.ois.jhove.module.pdf.PdfSimpleObject@43bd930a
       Item: 
        Title: TGFBI hypermethylation in trastuzumab-resistant HER2+ breast cancer patients
        Destination: edu.harvard.hul.ois.jhove.module.pdf.PdfSimpleObject@33723e30
     Item: 
      Title: Discussion
      Destination: edu.harvard.hul.ois.jhove.module.pdf.PdfSimpleObject@64f6106c
     Item: 
      Title: Conclusions
      Destination: edu.harvard.hul.ois.jhove.module.pdf.PdfSimpleObject@553a3d88
     Item: 
      Title: Additional files
      Destination: edu.harvard.hul.ois.jhove.module.pdf.PdfSimpleObject@7a30d1e6
     Item: 
      Title: Abbreviations
      Destination: edu.harvard.hul.ois.jhove.module.pdf.PdfSimpleObject@5891e32e
     Item: 
      Title: Acknowledgements
      Destination: edu.harvard.hul.ois.jhove.module.pdf.PdfSimpleObject@cb0ed20
     Item: 
      Title: Authors’ contributions
      Destination: edu.harvard.hul.ois.jhove.module.pdf.PdfSimpleObject@8e24743
     Item: 
      Title: Funding
      Destination: edu.harvard.hul.ois.jhove.module.pdf.PdfSimpleObject@74a10858
     Item: 
      Title: Availability of data and materials
      Destination: edu.harvard.hul.ois.jhove.module.pdf.PdfSimpleObject@23fe1d71
     Item: 
      Title: Ethics approval and consent to participate
      Destination: edu.harvard.hul.ois.jhove.module.pdf.PdfSimpleObject@28ac3dc3
     Item: 
      Title: Consent for publication
      Destination: edu.harvard.hul.ois.jhove.module.pdf.PdfSimpleObject@32eebfca
     Item: 
      Title: Competing interests
      Destination: edu.harvard.hul.ois.jhove.module.pdf.PdfSimpleObject@4e718207
     Item: 
      Title: Author details
      Destination: edu.harvard.hul.ois.jhove.module.pdf.PdfSimpleObject@1d371b2d
     Item: 
      Title: References
      Destination: edu.harvard.hul.ois.jhove.module.pdf.PdfSimpleObject@543c6f6d
     Item: 
      Title: Publisher’s Note
      Destination: edu.harvard.hul.ois.jhove.module.pdf.PdfSimpleObject@13eb8acf
   Info: 
    Title: Epigenetic silencing of TGFBI confers resistance to trastuzumab in human breast cancer
    Author: Sònia Palomeras
    Subject: Breast Cancer Research, 2019, doi:10.1186/s13058-019-1160-x
    Keywords: HER2+ breast cancer,Trastuzumab resistance,DNA methylation,TGFBI
    Creator: Arbortext Advanced Print Publisher 9.1.440/W Unicode
    Producer: Acrobat Distiller 10.1.5 (Windows); modified using iText® 5.3.5 ©2000-2012 1T3XT BVBA (AGPL-version)
    CreationDate: Wed Jul 03 02:00:38 CEST 2019
    ModDate: Fri Jul 05 14:43:22 CEST 2019
   ID: 0xc318a0af77b0774bd1c5c94328f5bc41, 0xb8066fa17038ba4235361f8a58373a5a
   Filters: 
    FilterPipeline: FlateDecode
    FilterPipeline: DCTDecode
   Images: 
    Image: 
     NisoImageMetadata: 
      FormatName: image/jpg
      CompressionScheme: JPEG
      ImageWidth: 176
      ImageHeight: 182
      BitsPerSample: 8
      BitsPerSampleUnit: integer
     Intent: Perceptual
    Image: 
     NisoImageMetadata: 
      FormatName: image/png
      ImageWidth: 688
      ImageHeight: 126
      BitsPerSample: 8
      BitsPerSampleUnit: integer
     Filter: FlateDecode
    Image: 
     NisoImageMetadata: 
      FormatName: image/png
      ImageWidth: 54
      ImageHeight: 103
      BitsPerSample: 8
      BitsPerSampleUnit: integer
     Filter: FlateDecode
    Image: 
     NisoImageMetadata: 
      FormatName: image/png
      ImageWidth: 1406
      ImageHeight: 1488
      BitsPerSample: 8
      BitsPerSampleUnit: integer
     Filter: FlateDecode
     Intent: Perceptual
    Image: 
     NisoImageMetadata: 
      FormatName: image/png
      ImageWidth: 1295
      ImageHeight: 639
      BitsPerSample: 8
      BitsPerSampleUnit: integer
     Filter: FlateDecode
    Image: 
     NisoImageMetadata: 
      FormatName: image/jpg
      CompressionScheme: JPEG
      ImageWidth: 1817
      ImageHeight: 1293
      BitsPerSample: 8
      BitsPerSampleUnit: integer
     Intent: Perceptual
    Image: 
     NisoImageMetadata: 
      FormatName: image/png
      ImageWidth: 1100
      ImageHeight: 90
      ColorSpace: black is zero
      BitsPerSample: 1
      BitsPerSampleUnit: integer
     Filter: FlateDecode
   Fonts: 
    Type1: 
     Font: 
      BaseFont: AONGKB+RrfktyAdvTTb5929f4c+03
      FontSubset: true
      FirstChar: 1
      LastChar: 6
      FontDescriptor: 
       FontName: AONGKB+RrfktyAdvTTb5929f4c+03
       Flags: Symbolic
       FontBBox: -531, -260, 802, 968
       FontFile3: true
      EncodingDictionary: 
       Differences: true
      ToUnicode: true
     Font: 
      BaseFont: AONGHO+TghlrxHelvetica-Bold
      FontSubset: true
      FirstChar: 32
      LastChar: 70
      FontDescriptor: 
       FontName: AONGHO+TghlrxHelvetica-Bold
       Flags: Nonsymbolic, ForceBold
       FontBBox: -170, -228, 1003, 962
       FontFile3: true
      Encoding: WinAnsiEncoding
     Font: 
      BaseFont: AONCMB+QxddryAdvTT86d47313+21
      FontSubset: true
      FirstChar: 32
      LastChar: 153
      FontDescriptor: 
       FontName: AONCMB+QxddryAdvTT86d47313+21
       Flags: Nonsymbolic
       FontBBox: -20, -208, 1208, 802
       FontFile3: true
      Encoding: WinAnsiEncoding
     Font: 
      BaseFont: AONGJP+DqqhvgAdvTT1b53b5fb.I+03
      FontSubset: true
      FirstChar: 1
      LastChar: 2
      FontDescriptor: 
       FontName: AONGJP+DqqhvgAdvTT1b53b5fb.I+03
       Flags: Symbolic
       FontBBox: -572, -260, 947, 968
       FontFile3: true
      EncodingDictionary: 
       Differences: true
      ToUnicode: true
     Font: 
      BaseFont: AONCMC+RtgjxbAdvTT86d47313+22
      FontSubset: true
      FirstChar: 1
      LastChar: 4
      FontDescriptor: 
       FontName: AONCMC+RtgjxbAdvTT86d47313+22
       Flags: Symbolic
       FontBBox: -166, -260, 1031, 906
       FontFile3: true
      EncodingDictionary: 
       Differences: true
      ToUnicode: true
     Font: 
      BaseFont: AOODGD+XddbnsAdvTTaf7f9f4f.B+20
      FontSubset: true
      FirstChar: 32
      LastChar: 146
      FontDescriptor: 
       FontName: AOODGD+XddbnsAdvTTaf7f9f4f.B+20
       Flags: Nonsymbolic
       FontBBox: -468, -197, 1656, 864
       FontFile3: true
      Encoding: WinAnsiEncoding
     Font: 
      BaseFont: AONBEN+YqqmcsAdvTTaf7f9f4f.B
      FontSubset: true
      FirstChar: 32
      LastChar: 117
      FontDescriptor: 
       FontName: AONBEN+YqqmcsAdvTTaf7f9f4f.B
       Flags: Nonsymbolic
       FontBBox: -218, -250, 875, 895
       FontFile3: true
      Encoding: WinAnsiEncoding
     Font: 
      BaseFont: AONBJM+XkvhgsAdvTTe45e47d2
      FontSubset: true
      FirstChar: 32
      LastChar: 122
      FontDescriptor: 
       FontName: AONBJM+XkvhgsAdvTTe45e47d2
       Flags: Nonsymbolic
       FontBBox: -218, -250, 833, 875
       FontFile3: true
      Encoding: WinAnsiEncoding
     Font: 
      BaseFont: AONBJN+QphwmhAdvTT7329fd89.I
      FontSubset: true
      FirstChar: 32
      LastChar: 116
      FontDescriptor: 
       FontName: AONBJN+QphwmhAdvTT7329fd89.I
       Flags: Nonsymbolic
       FontBBox: -218, -250, 885, 864
       FontFile3: true
      Encoding: WinAnsiEncoding
     Font: 
      BaseFont: AONCGA+BbbgwyAdvTT86d47313+20
      FontSubset: true
      FirstChar: 2
      LastChar: 151
      FontDescriptor: 
       FontName: AONCGA+BbbgwyAdvTT86d47313+20
       Flags: Symbolic
       FontBBox: -218, -218, 1291, 812
       FontFile3: true
      EncodingDictionary: 
       Differences: true
      ToUnicode: true
     Font: 
      BaseFont: MyriadPro-Regular
      FirstChar: 1
      LastChar: 255
      FontDescriptor: 
       FontName: MyriadPro-Regular
       Flags: Nonsymbolic
       FontBBox: -46, -250, 1126, 879
       FontFile: true
      EncodingDictionary: 
       BaseEncoding: WinAnsiEncoding
       Differences: true
     Font: 
      BaseFont: AONCHA+JhvsygAdvTT8861b38f.I
      FontSubset: true
      FirstChar: 32
      LastChar: 117
      FontDescriptor: 
       FontName: AONCHA+JhvsygAdvTT8861b38f.I
       Flags: Serif, Nonsymbolic
       FontBBox: -187, -239, 1062, 875
       FontFile3: true
      Encoding: WinAnsiEncoding
     Font: 
      BaseFont: AONBKA+SspyffAdvTT99c4c969
      FontSubset: true
      FirstChar: 32
      LastChar: 122
      FontDescriptor: 
       FontName: AONBKA+SspyffAdvTT99c4c969
       Flags: Nonsymbolic
       FontBBox: -41, -250, 854, 885
       FontFile3: true
      Encoding: WinAnsiEncoding
     Font: 
      BaseFont: AONCFP+KjsrddAdvTT86d47313
      FontSubset: true
      FirstChar: 32
      LastChar: 215
      FontDescriptor: 
       FontName: AONCFP+KjsrddAdvTT86d47313
       Flags: Serif, Nonsymbolic
       FontBBox: -218, -239, 1020, 875
       FontFile3: true
      Encoding: WinAnsiEncoding
     Font: 
      BaseFont: AONBJP+PfrjtlAdvTTb5929f4c+20
      FontSubset: true
      FirstChar: 2
      LastChar: 145
      FontDescriptor: 
       FontName: AONBJP+PfrjtlAdvTTb5929f4c+20
       Flags: Symbolic
       FontBBox: -447, -208, 1375, 864
       FontFile3: true
      EncodingDictionary: 
       Differences: true
      ToUnicode: true
     Font: 
      BaseFont: AONCHB+SxlwnjAdvTT86d47313+03
      FontSubset: true
      FirstChar: 1
      LastChar: 6
      FontDescriptor: 
       FontName: AONCHB+SxlwnjAdvTT86d47313+03
       Flags: Symbolic
       FontBBox: -281, -250, 906, 885
       FontFile3: true
      EncodingDictionary: 
       Differences: true
      ToUnicode: true
     Font: 
      BaseFont: AONBKB+VrpvfbAdvTT1b53b5fb.I
      FontSubset: true
      FirstChar: 32
      LastChar: 117
      FontDescriptor: 
       FontName: AONBKB+VrpvfbAdvTT1b53b5fb.I
       Flags: Nonsymbolic
       FontBBox: -114, -250, 864, 854
       FontFile3: true
      Encoding: WinAnsiEncoding
     Font: 
      BaseFont: AONCJB+KpqcfnAdvTT99c4c969+20
      FontSubset: true
      FirstChar: 1
      LastChar: 145
      FontDescriptor: 
       FontName: AONCJB+KpqcfnAdvTT99c4c969+20
       Flags: Symbolic
       FontBBox: -447, -197, 1583, 864
       FontFile3: true
      EncodingDictionary: 
       Differences: true
      ToUnicode: true
     Font: 
      BaseFont: AONCND+NhrqvfAdvTT8861b38f.I+03
      FontSubset: true
      FirstChar: 1
      LastChar: 2
      FontDescriptor: 
       FontName: AONCND+NhrqvfAdvTT8861b38f.I+03
       Flags: Symbolic
       FontBBox: -291, -239, 937, 885
       FontFile3: true
      EncodingDictionary: 
       Differences: true
      ToUnicode: true
     Font: 
      BaseFont: AONCOE+MxylxyAdvTT83913201.I
      FontSubset: true
      FirstChar: 32
      LastChar: 88
      FontDescriptor: 
       FontName: AONCOE+MxylxyAdvTT83913201.I
       Flags: Nonsymbolic
       FontBBox: -93, -250, 906, 875
       FontFile3: true
      Encoding: WinAnsiEncoding
     Font: 
      BaseFont: AONGKA+MskgmjAdvTTb5929f4c+22
      FontSubset: true
      FirstChar: 1
      LastChar: 139
      FontDescriptor: 
       FontName: AONGKA+MskgmjAdvTTb5929f4c+22
       Flags: Symbolic
       FontBBox: -10, -218, 1083, 906
       FontFile3: true
      EncodingDictionary: 
       Differences: true
      ToUnicode: true
     Font: 
      BaseFont: AONBJO+HcbtckAdvTTb5929f4c
      FontSubset: true
      FirstChar: 32
      LastChar: 250
      FontDescriptor: 
       FontName: AONBJO+HcbtckAdvTTb5929f4c
       Flags: Nonsymbolic
       FontBBox: -41, -250, 812, 864
       FontFile3: true
      Encoding: WinAnsiEncoding
   XMP: <x:xmpmeta x:xmptk="Adobe XMP Core 4.2.1-c041 52.342996, 2008/05/07-20:48:00        " xmlns:x="adobe:ns:meta/">
   <rdf:RDF xmlns:rdf="http://www.w3.org/1999/02/22-rdf-syntax-ns#">
      <rdf:Description rdf:about="" xmlns:pdf="http://ns.adobe.com/pdf/1.3/">
         <pdf:Keywords>HER2+ breast cancer,Trastuzumab resistance,DNA methylation,TGFBI</pdf:Keywords>
         <pdf:Producer>Acrobat Distiller 10.1.5 (Windows); modified using iText® 5.3.5 ©2000-2012 1T3XT BVBA (AGPL-version)</pdf:Producer>
      </rdf:Description>
      <rdf:Description rdf:about="" xmlns:dc="http://purl.org/dc/elements/1.1/">
         <dc:format>application/pdf</dc:format>
         <dc:identifier>10.1186/s13058-019-1160-x</dc:identifier>
         <dc:publisher>
            <rdf:Bag>
               <rdf:li>Breast Cancer Research</rdf:li>
            </rdf:Bag>
         </dc:publisher>
         <dc:description>
            <rdf:Alt>
               <rdf:li xml:lang="x-default">Breast Cancer Research, 2019, doi:10.1186/s13058-019-1160-x</rdf:li>
            </rdf:Alt>
         </dc:description>
         <dc:subject>
            <rdf:Bag>
               <rdf:li>HER2+ breast cancer</rdf:li>
               <rdf:li>Trastuzumab resistance</rdf:li>
               <rdf:li>DNA methylation</rdf:li>
               <rdf:li>TGFBI</rdf:li>
            </rdf:Bag>
         </dc:subject>
         <dc:title>
            <rdf:Alt>
               <rdf:li xml:lang="x-default">Epigenetic silencing of TGFBI confers resistance to trastuzumab in human breast cancer</rdf:li>
            </rdf:Alt>
         </dc:title>
         <dc:creator>
            <rdf:Seq>
               <rdf:li>Sònia Palomeras</rdf:li>
               <rdf:li>Ángel Diaz-Lagares</rdf:li>
               <rdf:li>Gemma Viñas</rdf:li>
               <rdf:li>Fernando Setien</rdf:li>
               <rdf:li>Humberto J. Ferreira</rdf:li>
               <rdf:li>Glòria Oliveras</rdf:li>
               <rdf:li>Ana B. Crujeiras</rdf:li>
               <rdf:li>Alejandro Hernández</rdf:li>
               <rdf:li>David H. Lum</rdf:li>
               <rdf:li>Alana L. Welm</rdf:li>
               <rdf:li>Manel Esteller</rdf:li>
               <rdf:li>Teresa Puig</rdf:li>
            </rdf:Seq>
         </dc:creator>
      </rdf:Description>
      <rdf:Description rdf:about="" xmlns:xmp="http://ns.adobe.com/xap/1.0/">
         <xmp:MetadataDate>2019-07-05T14:43:22+02:00</xmp:MetadataDate>
         <xmp:CreateDate>2019-07-03T08:00:38+08:00</xmp:CreateDate>
         <xmp:CreatorTool>Arbortext Advanced Print Publisher 9.1.440/W Unicode</xmp:CreatorTool>
         <xmp:ModifyDate>2019-07-05T14:43:22+02:00</xmp:ModifyDate>
      </rdf:Description>
      <rdf:Description rdf:about="" xmlns:stEvt="http://ns.adobe.com/xap/1.0/sType/ResourceEvent#" xmlns:xmpMM="http://ns.adobe.com/xap/1.0/mm/">
         <xmpMM:DocumentID>uuid:0a51b445-cbb1-49de-80ad-1ad881d4327c</xmpMM:DocumentID>
         <xmpMM:InstanceID>uuid:17359276-29b2-41c8-a4bb-92a535f41c7f</xmpMM:InstanceID>
         <xmpMM:RenditionClass>default</xmpMM:RenditionClass>
         <xmpMM:VersionID>1</xmpMM:VersionID>
         <xmpMM:History>
            <rdf:Seq>
               <rdf:li rdf:parseType="Resource">
                  <stEvt:action>converted</stEvt:action>
                  <stEvt:instanceID>uuid:9ac616db-d9cd-4983-ab70-508ba524b385</stEvt:instanceID>
                  <stEvt:parameters>converted to PDF/A-2b</stEvt:parameters>
                  <stEvt:softwareAgent>pdfToolbox</stEvt:softwareAgent>
                  <stEvt:when>2019-07-03T09:02:47+08:00</stEvt:when>
               </rdf:li>
            </rdf:Seq>
         </xmpMM:History>
      </rdf:Description>
      <rdf:Description rdf:about="" xmlns:pdfaid="http://www.aiim.org/pdfa/ns/id/">
         <pdfaid:part>2</pdfaid:part>
         <pdfaid:conformance>B</pdfaid:conformance>
      </rdf:Description>
      <rdf:Description rdf:about="" xmlns:pdfaExtension="http://www.aiim.org/pdfa/ns/extension/" xmlns:pdfaField="http://www.aiim.org/pdfa/ns/field#" xmlns:pdfaProperty="http://www.aiim.org/pdfa/ns/property#" xmlns:pdfaSchema="http://www.aiim.org/pdfa/ns/schema#" xmlns:pdfaType="http://www.aiim.org/pdfa/ns/type#">
         <pdfaExtension:schemas>
            <rdf:Bag>
               <rdf:li rdf:parseType="Resource">
                  <pdfaSchema:schema>Springer Nature ORCID Schema</pdfaSchema:schema>
                  <pdfaSchema:namespaceURI>http://springernature.com/ns/xmpExtensions/2.0/</pdfaSchema:namespaceURI>
                  <pdfaSchema:prefix>sn</pdfaSchema:prefix>
                  <pdfaSchema:property>
                     <rdf:Seq>
                        <rdf:li rdf:parseType="Resource">
                           <pdfaProperty:name>authorInfo</pdfaProperty:name>
                           <pdfaProperty:valueType>Bag AuthorInformation</pdfaProperty:valueType>
                           <pdfaProperty:category>external</pdfaProperty:category>
                           <pdfaProperty:description>Author information: contains the name of each author and his/her ORCID (ORCiD: Open Researcher and Contributor ID). An ORCID is a persistent identifier (a non-proprietary alphanumeric code) to uniquely identify scientific and other academic authors.</pdfaProperty:description>
                        </rdf:li>
                        <rdf:li rdf:parseType="Resource">
                           <pdfaProperty:name>editorInfo</pdfaProperty:name>
                           <pdfaProperty:valueType>Bag EditorInformation</pdfaProperty:valueType>
                           <pdfaProperty:category>external</pdfaProperty:category>
                           <pdfaProperty:description>Editor information: contains the name of each editor and his/her ORCID identifier.</pdfaProperty:description>
                        </rdf:li>
                        <rdf:li rdf:parseType="Resource">
                           <pdfaProperty:name>seriesEditorInfo</pdfaProperty:name>
                           <pdfaProperty:valueType>Bag SeriesEditorInformation</pdfaProperty:valueType>
                           <pdfaProperty:category>external</pdfaProperty:category>
                           <pdfaProperty:description>Series editor information: contains the name of each series editor and his/her ORCID identifier.</pdfaProperty:description>
                        </rdf:li>
                     </rdf:Seq>
                  </pdfaSchema:property>
                  <pdfaSchema:valueType>
                     <rdf:Seq>
                        <rdf:li rdf:parseType="Resource">
                           <pdfaType:type>AuthorInformation</pdfaType:type>
                           <pdfaType:namespaceURI>http://springernature.com/ns/xmpExtensions/2.0/authorInfo/</pdfaType:namespaceURI>
                           <pdfaType:prefix>author</pdfaType:prefix>
                           <pdfaType:description>Specifies the types of author information: name and ORCID of an author.</pdfaType:description>
                           <pdfaType:field>
                              <rdf:Seq>
                                 <rdf:li rdf:parseType="Resource">
                                    <pdfaField:name>name</pdfaField:name>
                                    <pdfaField:valueType>Text</pdfaField:valueType>
                                    <pdfaField:description>Gives the name of an author.</pdfaField:description>
                                 </rdf:li>
                                 <rdf:li rdf:parseType="Resource">
                                    <pdfaField:name>orcid</pdfaField:name>
                                    <pdfaField:valueType>URI</pdfaField:valueType>
                                    <pdfaField:description>Gives the ORCID of an author.</pdfaField:description>
                                 </rdf:li>
                              </rdf:Seq>
                           </pdfaType:field>
                        </rdf:li>
                        <rdf:li rdf:parseType="Resource">
                           <pdfaType:type>EditorInformation</pdfaType:type>
                           <pdfaType:namespaceURI>http://springernature.com/ns/xmpExtensions/2.0/editorInfo/</pdfaType:namespaceURI>
                           <pdfaType:prefix>editor</pdfaType:prefix>
                           <pdfaType:description>Specifies the types of editor information: name and ORCID of an editor.</pdfaType:description>
                           <pdfaType:field>
                              <rdf:Seq>
                                 <rdf:li rdf:parseType="Resource">
                                    <pdfaField:name>name</pdfaField:name>
                                    <pdfaField:valueType>Text</pdfaField:valueType>
                                    <pdfaField:description>Gives the name of an editor.</pdfaField:description>
                                 </rdf:li>
                                 <rdf:li rdf:parseType="Resource">
                                    <pdfaField:name>orcid</pdfaField:name>
                                    <pdfaField:valueType>URI</pdfaField:valueType>
                                    <pdfaField:description>Gives the ORCID of an editor.</pdfaField:description>
                                 </rdf:li>
                              </rdf:Seq>
                           </pdfaType:field>
                        </rdf:li>
                        <rdf:li rdf:parseType="Resource">
                           <pdfaType:type>SeriesEditorInformation</pdfaType:type>
                           <pdfaType:namespaceURI>http://springernature.com/ns/xmpExtensions/2.0/seriesEditorInfo/</pdfaType:namespaceURI>
                           <pdfaType:prefix>seriesEditor</pdfaType:prefix>
                           <pdfaType:description>Specifies the types of series editor information: name and ORCID of a series editor.</pdfaType:description>
                           <pdfaType:field>
                              <rdf:Seq>
                                 <rdf:li rdf:parseType="Resource">
                                    <pdfaField:name>name</pdfaField:name>
                                    <pdfaField:valueType>Text</pdfaField:valueType>
                                    <pdfaField:description>Gives the name of a series editor.</pdfaField:description>
                                 </rdf:li>
                                 <rdf:li rdf:parseType="Resource">
                                    <pdfaField:name>orcid</pdfaField:name>
                                    <pdfaField:valueType>URI</pdfaField:valueType>
                                    <pdfaField:description>Gives the ORCID of a series editor.</pdfaField:description>
                                 </rdf:li>
                              </rdf:Seq>
                           </pdfaType:field>
                        </rdf:li>
                     </rdf:Seq>
                  </pdfaSchema:valueType>
               </rdf:li>
               <rdf:li rdf:parseType="Resource">
                  <pdfaSchema:namespaceURI>http://ns.adobe.com/pdf/1.3/</pdfaSchema:namespaceURI>
                  <pdfaSchema:prefix>pdf</pdfaSchema:prefix>
                  <pdfaSchema:schema>Adobe PDF Schema</pdfaSchema:schema>
                  <pdfaSchema:property>
                     <rdf:Seq>
                        <rdf:li rdf:parseType="Resource">
                           <pdfaProperty:category>internal</pdfaProperty:category>
                           <pdfaProperty:description>A name object indicating whether the document has been modified to include trapping information</pdfaProperty:description>
                           <pdfaProperty:name>Trapped</pdfaProperty:name>
                           <pdfaProperty:valueType>Text</pdfaProperty:valueType>
                        </rdf:li>
                     </rdf:Seq>
                  </pdfaSchema:property>
               </rdf:li>
               <rdf:li rdf:parseType="Resource">
                  <pdfaSchema:namespaceURI>http://ns.adobe.com/xap/1.0/mm/</pdfaSchema:namespaceURI>
                  <pdfaSchema:prefix>xmpMM</pdfaSchema:prefix>
                  <pdfaSchema:schema>XMP Media Management Schema</pdfaSchema:schema>
                  <pdfaSchema:property>
                     <rdf:Seq>
                        <rdf:li rdf:parseType="Resource">
                           <pdfaProperty:category>internal</pdfaProperty:category>
                           <pdfaProperty:description>UUID based identifier for specific incarnation of a document</pdfaProperty:description>
                           <pdfaProperty:name>InstanceID</pdfaProperty:name>
                           <pdfaProperty:valueType>URI</pdfaProperty:valueType>
                        </rdf:li>
                        <rdf:li rdf:parseType="Resource">
                           <pdfaProperty:category>internal</pdfaProperty:category>
                           <pdfaProperty:description>The common identifier for all versions and renditions of a document.</pdfaProperty:description>
                           <pdfaProperty:name>OriginalDocumentID</pdfaProperty:name>
                           <pdfaProperty:valueType>URI</pdfaProperty:valueType>
                        </rdf:li>
                        <rdf:li rdf:parseType="Resource">
                           <pdfaProperty:category>internal</pdfaProperty:category>
                           <pdfaProperty:description>A reference to the original document from which this one is derived. It is a minimal reference; missing components can be assumed to be unchanged. For example, a new version might only need to specify the instance ID and version number of the previous version, or a rendition might only need to specify the instance ID and rendition class of the original.</pdfaProperty:description>
                           <pdfaProperty:name>DerivedFrom</pdfaProperty:name>
                           <pdfaProperty:valueType>ResourceRef</pdfaProperty:valueType>
                        </rdf:li>
                     </rdf:Seq>
                  </pdfaSchema:property>
                  <pdfaSchema:valueType>
                     <rdf:Seq>
                        <rdf:li rdf:parseType="Resource">
                           <pdfaType:description>Identifies a portion of a document. This can be a position at which the document has been changed since the most recent event history (stEvt:changed). For a resource within an xmpMM:Ingredients list, the ResourceRef uses this type to identify both the portion of the containing document that refers to the resource, and the portion of the referenced resource that is referenced.</pdfaType:description>
                           <pdfaType:namespaceURI>http://ns.adobe.com/xap/1.0/sType/Part#</pdfaType:namespaceURI>
                           <pdfaType:prefix>stPart</pdfaType:prefix>
                           <pdfaType:type>Part</pdfaType:type>
                        </rdf:li>
                     </rdf:Seq>
                  </pdfaSchema:valueType>
               </rdf:li>
               <rdf:li rdf:parseType="Resource">
                  <pdfaSchema:namespaceURI>http://ns.adobe.com/xap/1.0/t/pg/</pdfaSchema:namespaceURI>
                  <pdfaSchema:prefix>xmpTPg</pdfaSchema:prefix>
                  <pdfaSchema:schema>XMP Paged-Text</pdfaSchema:schema>
                  <pdfaSchema:property>
                     <rdf:Seq>
                        <rdf:li rdf:parseType="Resource">
                           <pdfaProperty:category>internal</pdfaProperty:category>
                           <pdfaProperty:description>A structure containing the characteristics of a font used in a document</pdfaProperty:description>
                           <pdfaProperty:name>Fonts</pdfaProperty:name>
                           <pdfaProperty:valueType>Bag Font</pdfaProperty:valueType>
                        </rdf:li>
                        <rdf:li rdf:parseType="Resource">
                           <pdfaProperty:category>internal</pdfaProperty:category>
                           <pdfaProperty:description>XMP08 Spec: An ordered array of plate names that are needed to print the document (including any in contained documents).</pdfaProperty:description>
                           <pdfaProperty:name>PlateNames</pdfaProperty:name>
                           <pdfaProperty:valueType>Seq Text</pdfaProperty:valueType>
                        </rdf:li>
                     </rdf:Seq>
                  </pdfaSchema:property>
                  <pdfaSchema:valueType>
                     <rdf:Seq>
                        <rdf:li rdf:parseType="Resource">
                           <pdfaType:description>A structure containing the characteristics of a font used in a document.</pdfaType:description>
                           <pdfaType:namespaceURI>http://ns.adobe.com/xap/1.0/sType/Font#</pdfaType:namespaceURI>
                           <pdfaType:prefix>stFnt</pdfaType:prefix>
                           <pdfaType:type>Font</pdfaType:type>
                        </rdf:li>
                     </rdf:Seq>
                  </pdfaSchema:valueType>
               </rdf:li>
               <rdf:li rdf:parseType="Resource">
                  <pdfaSchema:namespaceURI>http://ns.adobe.com/pdfx/1.3/</pdfaSchema:namespaceURI>
                  <pdfaSchema:prefix>pdfx</pdfaSchema:prefix>
                  <pdfaSchema:schema>PDF/X ID Schema</pdfaSchema:schema>
                  <pdfaSchema:property>
                     <rdf:Seq>
                        <rdf:li rdf:parseType="Resource">
                           <pdfaProperty:category>internal</pdfaProperty:category>
                           <pdfaProperty:description>ID of PDF/X standard</pdfaProperty:description>
                           <pdfaProperty:name>GTS_PDFXVersion</pdfaProperty:name>
                           <pdfaProperty:valueType>Text</pdfaProperty:valueType>
                        </rdf:li>
                        <rdf:li rdf:parseType="Resource">
                           <pdfaProperty:category>internal</pdfaProperty:category>
                           <pdfaProperty:description>Conformance level of PDF/X standard</pdfaProperty:description>
                           <pdfaProperty:name>GTS_PDFXConformance</pdfaProperty:name>
                           <pdfaProperty:valueType>Text</pdfaProperty:valueType>
                        </rdf:li>
                        <rdf:li rdf:parseType="Resource">
                           <pdfaProperty:category>internal</pdfaProperty:category>
                           <pdfaProperty:description>Company creating the PDF</pdfaProperty:description>
                           <pdfaProperty:name>Company</pdfaProperty:name>
                           <pdfaProperty:valueType>Text</pdfaProperty:valueType>
                        </rdf:li>
                        <rdf:li rdf:parseType="Resource">
                           <pdfaProperty:category>internal</pdfaProperty:category>
                           <pdfaProperty:description>Date when document was last modified</pdfaProperty:description>
                           <pdfaProperty:name>SourceModified</pdfaProperty:name>
                           <pdfaProperty:valueType>Text</pdfaProperty:valueType>
                        </rdf:li>
                     </rdf:Seq>
                  </pdfaSchema:property>
               </rdf:li>
               <rdf:li rdf:parseType="Resource">
                  <pdfaSchema:namespaceURI>http://www.aiim.org/pdfa/ns/id/</pdfaSchema:namespaceURI>
                  <pdfaSchema:prefix>pdfaid</pdfaSchema:prefix>
                  <pdfaSchema:schema>PDF/A ID Schema</pdfaSchema:schema>
                  <pdfaSchema:property>
                     <rdf:Seq>
                        <rdf:li rdf:parseType="Resource">
                           <pdfaProperty:category>internal</pdfaProperty:category>
                           <pdfaProperty:description>Part of PDF/A standard</pdfaProperty:description>
                           <pdfaProperty:name>part</pdfaProperty:name>
                           <pdfaProperty:valueType>Integer</pdfaProperty:valueType>
                        </rdf:li>
                        <rdf:li rdf:parseType="Resource">
                           <pdfaProperty:category>internal</pdfaProperty:category>
                           <pdfaProperty:description>Amendment of PDF/A standard</pdfaProperty:description>
                           <pdfaProperty:name>amd</pdfaProperty:name>
                           <pdfaProperty:valueType>Text</pdfaProperty:valueType>
                        </rdf:li>
                        <rdf:li rdf:parseType="Resource">
                           <pdfaProperty:category>internal</pdfaProperty:category>
                           <pdfaProperty:description>Conformance level of PDF/A standard</pdfaProperty:description>
                           <pdfaProperty:name>conformance</pdfaProperty:name>
                           <pdfaProperty:valueType>Text</pdfaProperty:valueType>
                        </rdf:li>
                     </rdf:Seq>
                  </pdfaSchema:property>
               </rdf:li>
            </rdf:Bag>
         </pdfaExtension:schemas>
      </rdf:Description>
   </rdf:RDF>
</x:xmpmeta>
   Pages: 
    Page: 
     Label: 1
     Annotations: 
      Annotation: 
       Subtype: Link
       Rect: 496, 635, 538, 677
       Flags: Print
       AppearanceDictionary: true
      Annotation: 
       Subtype: Link
       Rect: 239, 65, 357, 72
       Flags: Print
       AppearanceDictionary: true
      Annotation: 
       Subtype: Link
       Rect: 182, 41, 321, 48
       Flags: Print
       AppearanceDictionary: true
      Annotation: 
       Subtype: Link
       Rect: 114, 153, 175, 161
       Flags: Print
       AppearanceDictionary: true
      Annotation: 
       Subtype: Link
       Rect: 178, 153, 241, 161
       Flags: Print
       AppearanceDictionary: true
     Thumb: true
    Page: 
     Label: 2
     Annotations: 
      Annotation: 
       Subtype: Link
       Rect: 93, 657, 98, 666
       Flags: Print
       AppearanceDictionary: true
       Destination: null
      Annotation: 
       Subtype: Link
       Rect: 167, 633, 172, 642
       Flags: Print
       AppearanceDictionary: true
       Destination: null
      Annotation: 
       Subtype: Link
       Rect: 283, 573, 288, 582
       Flags: Print
       AppearanceDictionary: true
       Destination: null
      Annotation: 
       Subtype: Link
       Rect: 56, 561, 61, 570
       Flags: Print
       AppearanceDictionary: true
       Destination: null
      Annotation: 
       Subtype: Link
       Rect: 150, 525, 155, 534
       Flags: Print
       AppearanceDictionary: true
       Destination: null
      Annotation: 
       Subtype: Link
       Rect: 216, 429, 221, 438
       Flags: Print
       AppearanceDictionary: true
       Destination: null
      Annotation: 
       Subtype: Link
       Rect: 270, 333, 275, 342
       Flags: Print
       AppearanceDictionary: true
       Destination: 285
      Annotation: 
       Subtype: Link
       Rect: 209, 297, 214, 306
       Flags: Print
       AppearanceDictionary: true
       Destination: 285
      Annotation: 
       Subtype: Link
       Rect: 130, 165, 135, 174
       Flags: Print
       AppearanceDictionary: true
       Destination: 285
      Annotation: 
       Subtype: Link
       Rect: 92, 129, 102, 138
       Flags: Print
       AppearanceDictionary: true
       Destination: null
      Annotation: 
       Subtype: Link
       Rect: 87, 81, 97, 90
       Flags: Print
       AppearanceDictionary: true
       Destination: null
      Annotation: 
       Subtype: Link
       Rect: 196, 57, 206, 66
       Flags: Print
       AppearanceDictionary: true
       Destination: null
      Annotation: 
       Subtype: Link
       Rect: 275, 57, 285, 66
       Flags: Print
       AppearanceDictionary: true
       Destination: null
      Annotation: 
       Subtype: Link
       Rect: 504, 465, 513, 474
       Flags: Print
       AppearanceDictionary: true
       Destination: null
      Annotation: 
       Subtype: Link
       Rect: 359, 357, 368, 366
       Flags: Print
       AppearanceDictionary: true
       Destination: null
      Annotation: 
       Subtype: Link
       Rect: 350, 237, 360, 246
       Flags: Print
       AppearanceDictionary: true
       Destination: null
      Annotation: 
       Subtype: Link
       Rect: 365, 237, 374, 246
       Flags: Print
       AppearanceDictionary: true
       Destination: null
     Thumb: true
    Page: 
     Label: 3
     Annotations: 
      Annotation: 
       Subtype: Link
       Rect: 246, 609, 256, 618
       Flags: Print
       AppearanceDictionary: true
       Destination: null
      Annotation: 
       Subtype: Link
       Rect: 111, 501, 121, 510
       Flags: Print
       AppearanceDictionary: true
       Destination: null
      Annotation: 
       Subtype: Link
       Rect: 100, 165, 110, 174
       Flags: Print
       AppearanceDictionary: true
       Destination: null
      Annotation: 
       Subtype: Link
       Rect: 134, 69, 144, 78
       Flags: Print
       AppearanceDictionary: true
       Destination: null
      Annotation: 
       Subtype: Link
       Rect: 461, 561, 466, 570
       Flags: Print
       AppearanceDictionary: true
       Destination: 273
      Annotation: 
       Subtype: Link
       Rect: 531, 441, 536, 450
       Flags: Print
       AppearanceDictionary: true
       Destination: 273
      Annotation: 
       Subtype: Link
       Rect: 410, 141, 415, 150
       Flags: Print
       AppearanceDictionary: true
       Destination: 273
     Thumb: true
    Page: 
     Label: 4
     Annotations: 
      Annotation: 
       Subtype: Link
       Rect: 120, 645, 125, 654
       Flags: Print
       AppearanceDictionary: true
       Destination: 273
      Annotation: 
       Subtype: Link
       Rect: 124, 413, 134, 423
       Flags: Print
       AppearanceDictionary: true
       Destination: null
      Annotation: 
       Subtype: Link
       Rect: 242, 401, 247, 411
       Flags: Print
       AppearanceDictionary: true
       Destination: 273
      Annotation: 
       Subtype: Link
       Rect: 275, 240, 285, 250
       Flags: Print
       AppearanceDictionary: true
       Destination: null
      Annotation: 
       Subtype: Link
       Rect: 108, 105, 118, 114
       Flags: Print
       AppearanceDictionary: true
       Destination: null
      Annotation: 
       Subtype: Link
       Rect: 460, 597, 465, 606
       Flags: Print
       AppearanceDictionary: true
       Destination: 273
     Thumb: true
    Page: 
     Label: 5
     Annotations: 
      Annotation: 
       Subtype: Link
       Rect: 187, 597, 197, 606
       Flags: Print
       AppearanceDictionary: true
       Destination: null
      Annotation: 
       Subtype: Link
       Rect: 213, 561, 223, 570
       Flags: Print
       AppearanceDictionary: true
       Destination: null
      Annotation: 
       Subtype: Link
       Rect: 229, 561, 239, 570
       Flags: Print
       AppearanceDictionary: true
       Destination: null
      Annotation: 
       Subtype: Link
       Rect: 162, 501, 167, 510
       Flags: Print
       AppearanceDictionary: true
       Destination: 120
      Annotation: 
       Subtype: Link
       Rect: 180, 465, 184, 474
       Flags: Print
       AppearanceDictionary: true
       Destination: 120
      Annotation: 
       Subtype: Link
       Rect: 167, 309, 172, 318
       Flags: Print
       AppearanceDictionary: true
       Destination: 120
      Annotation: 
       Subtype: Link
       Rect: 116, 153, 121, 162
       Flags: Print
       AppearanceDictionary: true
       Destination: 120
      Annotation: 
       Subtype: Link
       Rect: 208, 57, 213, 66
       Flags: Print
       AppearanceDictionary: true
       Destination: 120
      Annotation: 
       Subtype: Link
       Rect: 397, 669, 402, 678
       Flags: Print
       AppearanceDictionary: true
       Destination: 142
      Annotation: 
       Subtype: Link
       Rect: 354, 585, 364, 594
       Flags: Print
       AppearanceDictionary: true
       Destination: null
      Annotation: 
       Subtype: Link
       Rect: 369, 585, 379, 594
       Flags: Print
       AppearanceDictionary: true
       Destination: null
      Annotation: 
       Subtype: Link
       Rect: 330, 501, 340, 510
       Flags: Print
       AppearanceDictionary: true
       Destination: null
      Annotation: 
       Subtype: Link
       Rect: 326, 477, 331, 486
       Flags: Print
       AppearanceDictionary: true
       Destination: 170
      Annotation: 
       Subtype: Link
       Rect: 466, 417, 470, 426
       Flags: Print
       AppearanceDictionary: true
       Destination: 170
      Annotation: 
       Subtype: Link
       Rect: 436, 357, 446, 366
       Flags: Print
       AppearanceDictionary: true
       Destination: null
      Annotation: 
       Subtype: Link
       Rect: 405, 333, 410, 342
       Flags: Print
       AppearanceDictionary: true
       Destination: 170
      Annotation: 
       Subtype: Link
       Rect: 401, 261, 406, 270
       Flags: Print
       AppearanceDictionary: true
       Destination: 170
      Annotation: 
       Subtype: Link
       Rect: 467, 177, 472, 186
       Flags: Print
       AppearanceDictionary: true
       Destination: 170
     Thumb: true
    Page: 
     Label: 6
     Annotations: 
      Annotation: 
       Subtype: Link
       Rect: 163, 117, 168, 126
       Flags: Print
       AppearanceDictionary: true
       Destination: 170
      Annotation: 
       Subtype: Link
       Rect: 254, 117, 259, 126
       Flags: Print
       AppearanceDictionary: true
       Destination: 273
     Thumb: true
    Page: 
     Label: 7
     Thumb: true
    Page: 
     Label: 8
     Annotations: 
      Annotation: 
       Subtype: Link
       Rect: 156, 369, 166, 378
       Flags: Print
       AppearanceDictionary: true
       Destination: null
      Annotation: 
       Subtype: Link
       Rect: 172, 369, 182, 378
       Flags: Print
       AppearanceDictionary: true
       Destination: null
      Annotation: 
       Subtype: Link
       Rect: 160, 321, 170, 330
       Flags: Print
       AppearanceDictionary: true
       Destination: null
      Annotation: 
       Subtype: Link
       Rect: 86, 225, 96, 234
       Flags: Print
       AppearanceDictionary: true
       Destination: null
      Annotation: 
       Subtype: Link
       Rect: 180, 165, 185, 174
       Flags: Print
       AppearanceDictionary: true
       Destination: 181
      Annotation: 
       Subtype: Link
       Rect: 98, 129, 103, 138
       Flags: Print
       AppearanceDictionary: true
       Destination: 181
      Annotation: 
       Subtype: Link
       Rect: 129, 69, 133, 78
       Flags: Print
       AppearanceDictionary: true
       Destination: 181
      Annotation: 
       Subtype: Link
       Rect: 206, 69, 211, 78
       Flags: Print
       AppearanceDictionary: true
       Destination: 273
      Annotation: 
       Subtype: Link
       Rect: 466, 561, 471, 570
       Flags: Print
       AppearanceDictionary: true
       Destination: 181
      Annotation: 
       Subtype: Link
       Rect: 354, 501, 358, 510
       Flags: Print
       AppearanceDictionary: true
       Destination: 181
      Annotation: 
       Subtype: Link
       Rect: 527, 453, 531, 462
       Flags: Print
       AppearanceDictionary: true
       Destination: 181
      Annotation: 
       Subtype: Link
       Rect: 476, 393, 480, 402
       Flags: Print
       AppearanceDictionary: true
       Destination: 181
     Thumb: true
    Page: 
     Label: 9
     Thumb: true
    Page: 
     Label: 10
     Annotations: 
      Annotation: 
       Subtype: Link
       Rect: 344, 141, 349, 150
       Flags: Print
       AppearanceDictionary: true
       Destination: 190
     Thumb: true
    Page: 
     Label: 11
     Annotations: 
      Annotation: 
       Subtype: Link
       Rect: 181, 609, 186, 618
       Flags: Print
       AppearanceDictionary: true
       Destination: 190
      Annotation: 
       Subtype: Link
       Rect: 507, 657, 512, 666
       Flags: Print
       AppearanceDictionary: true
       Destination: 190
      Annotation: 
       Subtype: Link
       Rect: 403, 573, 408, 582
       Flags: Print
       AppearanceDictionary: true
       Destination: 190
      Annotation: 
       Subtype: Link
       Rect: 430, 525, 434, 534
       Flags: Print
       AppearanceDictionary: true
       Destination: 273
      Annotation: 
       Subtype: Link
       Rect: 519, 489, 524, 498
       Flags: Print
       AppearanceDictionary: true
       Destination: 207
     Thumb: true
    Page: 
     Label: 12
     Annotations: 
      Annotation: 
       Subtype: Link
       Rect: 130, 609, 140, 618
       Flags: Print
       AppearanceDictionary: true
       Destination: null
      Annotation: 
       Subtype: Link
       Rect: 283, 573, 288, 582
       Flags: Print
       AppearanceDictionary: true
       Destination: 285
      Annotation: 
       Subtype: Link
       Rect: 56, 561, 61, 570
       Flags: Print
       AppearanceDictionary: true
       Destination: 285
      Annotation: 
       Subtype: Link
       Rect: 67, 561, 77, 570
       Flags: Print
       AppearanceDictionary: true
       Destination: null
      Annotation: 
       Subtype: Link
       Rect: 368, 609, 372, 618
       Flags: Print
       AppearanceDictionary: true
       Destination: 285
      Annotation: 
       Subtype: Link
       Rect: 378, 609, 388, 618
       Flags: Print
       AppearanceDictionary: true
       Destination: null
      Annotation: 
       Subtype: Link
       Rect: 456, 549, 466, 558
       Flags: Print
       AppearanceDictionary: true
       Destination: null
      Annotation: 
       Subtype: Link
       Rect: 471, 549, 481, 558
       Flags: Print
       AppearanceDictionary: true
       Destination: null
      Annotation: 
       Subtype: Link
       Rect: 438, 465, 448, 474
       Flags: Print
       AppearanceDictionary: true
       Destination: null
      Annotation: 
       Subtype: Link
       Rect: 451, 429, 460, 438
       Flags: Print
       AppearanceDictionary: true
       Destination: null
      Annotation: 
       Subtype: Link
       Rect: 330, 393, 339, 402
       Flags: Print
       AppearanceDictionary: true
       Destination: null
      Annotation: 
       Subtype: Link
       Rect: 364, 333, 373, 342
       Flags: Print
       AppearanceDictionary: true
       Destination: null
      Annotation: 
       Subtype: Link
       Rect: 378, 333, 388, 342
       Flags: Print
       AppearanceDictionary: true
       Destination: null
      Annotation: 
       Subtype: Link
       Rect: 347, 285, 357, 294
       Flags: Print
       AppearanceDictionary: true
       Destination: null
      Annotation: 
       Subtype: Link
       Rect: 523, 213, 533, 222
       Flags: Print
       AppearanceDictionary: true
       Destination: null
      Annotation: 
       Subtype: Link
       Rect: 508, 165, 517, 174
       Flags: Print
       AppearanceDictionary: true
       Destination: null
      Annotation: 
       Subtype: Link
       Rect: 523, 165, 533, 174
       Flags: Print
       AppearanceDictionary: true
       Destination: null
      Annotation: 
       Subtype: Link
       Rect: 341, 69, 351, 78
       Flags: Print
       AppearanceDictionary: true
       Destination: null
      Annotation: 
       Subtype: Link
       Rect: 357, 69, 367, 78
       Flags: Print
       AppearanceDictionary: true
       Destination: null
      Annotation: 
       Subtype: Link
       Rect: 372, 69, 382, 78
       Flags: Print
       AppearanceDictionary: true
       Destination: null
     Thumb: true
    Page: 
     Label: 13
     Annotations: 
      Annotation: 
       Subtype: Link
       Rect: 174, 693, 183, 702
       Flags: Print
       AppearanceDictionary: true
       Destination: null
      Annotation: 
       Subtype: Link
       Rect: 189, 693, 199, 702
       Flags: Print
       AppearanceDictionary: true
       Destination: null
      Annotation: 
       Subtype: Link
       Rect: 167, 669, 177, 678
       Flags: Print
       AppearanceDictionary: true
       Destination: null
      Annotation: 
       Subtype: Link
       Rect: 275, 597, 285, 606
       Flags: Print
       AppearanceDictionary: true
       Destination: null
      Annotation: 
       Subtype: Link
       Rect: 92, 465, 102, 474
       Flags: Print
       AppearanceDictionary: true
       Destination: null
      Annotation: 
       Subtype: Link
       Rect: 107, 465, 117, 474
       Flags: Print
       AppearanceDictionary: true
       Destination: null
      Annotation: 
       Subtype: Link
       Rect: 59, 441, 69, 450
       Flags: Print
       AppearanceDictionary: true
       Destination: null
      Annotation: 
       Subtype: Link
       Rect: 77, 441, 87, 450
       Flags: Print
       AppearanceDictionary: true
       Destination: null
      Annotation: 
       Subtype: Link
       Rect: 196, 405, 206, 414
       Flags: Print
       AppearanceDictionary: true
       Destination: null
      Annotation: 
       Subtype: Link
       Rect: 241, 297, 251, 306
       Flags: Print
       AppearanceDictionary: true
       Destination: null
      Annotation: 
       Subtype: Link
       Rect: 259, 297, 269, 306
       Flags: Print
       AppearanceDictionary: true
       Destination: null
      Annotation: 
       Subtype: Link
       Rect: 275, 297, 285, 306
       Flags: Print
       AppearanceDictionary: true
       Destination: null
      Annotation: 
       Subtype: Link
       Rect: 134, 237, 144, 246
       Flags: Print
       AppearanceDictionary: true
       Destination: null
      Annotation: 
       Subtype: Link
       Rect: 275, 81, 285, 90
       Flags: Print
       AppearanceDictionary: true
       Destination: null
      Annotation: 
       Subtype: Link
       Rect: 409, 693, 418, 702
       Flags: Print
       AppearanceDictionary: true
       Destination: null
      Annotation: 
       Subtype: Link
       Rect: 405, 633, 415, 642
       Flags: Print
       AppearanceDictionary: true
       Destination: null
      Annotation: 
       Subtype: Link
       Rect: 452, 537, 462, 546
       Flags: Print
       AppearanceDictionary: true
       Destination: null
      Annotation: 
       Subtype: Link
       Rect: 375, 429, 384, 438
       Flags: Print
       AppearanceDictionary: true
       Destination: null
      Annotation: 
       Subtype: Link
       Rect: 339, 405, 348, 414
       Flags: Print
       AppearanceDictionary: true
       Destination: null
      Annotation: 
       Subtype: Link
       Rect: 353, 405, 362, 414
       Flags: Print
       AppearanceDictionary: true
       Destination: null
      Annotation: 
       Subtype: Link
       Rect: 360, 177, 369, 186
       Flags: Print
       AppearanceDictionary: true
       Destination: null
      Annotation: 
       Subtype: Link
       Rect: 393, 57, 403, 66
       Flags: Print
       AppearanceDictionary: true
       Destination: 291
     Thumb: true
    Page: 
     Label: 14
     Annotations: 
      Annotation: 
       Subtype: Link
       Rect: 61, 405, 118, 412
       Flags: Print
       AppearanceDictionary: true
      Annotation: 
       Subtype: Link
       Rect: 61, 393, 118, 400
       Flags: Print
       AppearanceDictionary: true
      Annotation: 
       Subtype: Link
       Rect: 61, 210, 118, 217
       Flags: Print
       AppearanceDictionary: true
      Annotation: 
       Subtype: Link
       Rect: 61, 135, 118, 142
       Flags: Print
       AppearanceDictionary: true
      Annotation: 
       Subtype: Link
       Rect: 380, 231, 461, 238
       Flags: Print
       AppearanceDictionary: true
     Thumb: true
    Page: 
     Label: 15
     Thumb: true
    Page: 
     Label: 16
     Thumb: true
  Checksum: dec31b8a
   Type: CRC32
  Checksum: 03235336e9f029348e5908c3caa62739
   Type: MD5
  Checksum: f8157d167b4c5db48820dc143c6a2645f12d333a
   Type: SHA-1