651f2a2ec223a67a3e7d3fac77d43034 237066.pdf 325bc04a0d595918cd4dbca474a926273b7c0ef3 237066.pdf a10110ddc2fbc0460737b89d096e3a82ce87aaf4b627a05aac86dc08fa672383 237066.pdf Title: The transcribed pseudogene RPSAP52 enhances the oncofetal HMGA2-IGF2BP2-RAS axis through LIN28B-dependent and independent let-7 inhibition Subject: Nature Communications, doi:10.1038/s41467-019-11910-6 Keywords: Author: Cristina Oliveira-Mateos Creator: Springer Producer: iText® 5.3.5 ©2000-2012 1T3XT BVBA (AGPL-version) CreationDate: Wed Aug 28 10:26:24 2019 CEST ModDate: Thu Aug 29 15:52:40 2019 CEST Tagged: no UserProperties: no Suspects: no Form: AcroForm JavaScript: no Pages: 18 Encrypted: no Page size: 595.276 x 782.362 pts Page rot: 0 File size: 2639421 bytes Optimized: no PDF version: 1.4 name type encoding emb sub uni object ID ------------------------------------ ----------------- ---------------- --- --- --- --------- DKLGNE+AdvOTea1a7398 Type 1C WinAnsi yes yes no 105 0 DKLGNF+AdvOT9bd21c25.I Type 1C WinAnsi yes yes no 199 0 DKLKNO+AdvOTea1a7398+fb Type 1C Custom yes yes yes 200 0 DKLKOO+AdvOTcb88df00 Type 1C WinAnsi yes yes no 107 0 Arial-BoldMT Type 1C WinAnsi yes no no 994 0 DKLLDO+AdvOTf23bb480 Type 1C WinAnsi yes yes no 995 0 DKLLFA+AdvTTda6f6cb8.B Type 1C WinAnsi yes yes no 112 0 DKLLDP+AdvOTf23bb480+20 Type 1C WinAnsi yes yes no 996 0 DKLLLP+AdvOT1ef757c0 Type 1C WinAnsi yes yes no 106 0 DKLLNA+AdvOT1ef757c0+fb Type 1C Custom yes yes yes 108 0 DKLLOD+AdvOTb65e897d.B Type 1C WinAnsi yes yes no 109 0 DKLLLO+AdvOT125c650c Type 1C WinAnsi yes yes no 110 0 DKLLPD+AdvOT1ef757c0+20 Type 1C WinAnsi yes yes no 111 0 DKLLNB+AdvOT7d6df7ab.I Type 1C WinAnsi yes yes no 113 0 DKLLOC+AdvOT45bf69de.BI Type 1C WinAnsi yes yes no 114 0 DKLMAE+AdvTTab7e17fd Type 1C WinAnsi yes yes no 115 0 DKMDLJ+Helvetica-Bold Type 1C WinAnsi yes yes no 141 0 DKMDFJ+Helvetica-Oblique Type 1C WinAnsi yes yes no 142 0 DKMDGK+Symbol Type 1C Custom yes yes yes 143 0 DKMCKM+Helvetica Type 1C WinAnsi yes yes no 144 0 DKMEKE+AdvOT8608a8d1+20 Type 1C Custom yes yes yes 201 0 DKMELF+AdvTTab7e17fd+22 Type 1C Custom yes yes no 202 0 Helvetica2 Type 1C WinAnsi yes no no 251 0 DKNABB+AdvOT8608a8d1+22 Type 1C Custom yes yes yes 312 0 DKNACC+AdvOTea1a7398+20 Type 1C WinAnsi yes yes no 313 0 DKNACD+AdvOT8608a8d1 Type 1C WinAnsi yes yes no 314 0 DKNNIB+AdvOT7d6df7ab.I+03 Type 1C Custom yes yes yes 502 0 DKODIP+AdvTT7b515deb Type 1C WinAnsi yes yes no 522 0 DKODHO+AdvOTcb88df00+fb Type 1C Custom yes yes yes 523 0 DKODIO+AdvOT1ef757c0+03 Type 1C Custom yes yes yes 524 0 DKOKEH+AdvOT1ef757c0+21 Type 1C WinAnsi yes yes no 535 0 DKOLBF+AdvOT7d6df7ab.I+20 Type 1C WinAnsi yes yes no 548 0 DKOKPF+AdvTT3f84ef53 Type 1C WinAnsi yes yes no 549 0 DKOKPE+AdvP4C4E74 Type 1C WinAnsi yes yes no 550 0 DKOMCB+AdvOTb65e897d.B+20 Type 1C WinAnsi yes yes no 666 0 DKOMCA+AdvOT7d6df7ab.I+fb Type 1C Custom yes yes yes 667 0 Jhove (Rel. 1.22.1, 2019-04-17) Date: 2021-02-27 02:32:20 CET RepresentationInformation: 237066.pdf ReportingModule: PDF-hul, Rel. 1.12.1 (2019-04-17) LastModified: 2021-02-24 19:06:13 CET Size: 2639421 Format: PDF Version: 1.4 Status: Well-Formed, but not valid SignatureMatches: PDF-hul ID: PDF-HUL-122 ErrorMessage: edu.harvard.hul.ois.jhove.module.pdf.PdfInvalidException: Invalid indirect destination - referenced object 'bm_CR10' cannot be found Offset: 2164791 ID: PDF-HUL-122 ErrorMessage: edu.harvard.hul.ois.jhove.module.pdf.PdfInvalidException: Invalid indirect destination - referenced object 'bm_CR11' cannot be found Offset: 2164791 ID: PDF-HUL-122 ErrorMessage: edu.harvard.hul.ois.jhove.module.pdf.PdfInvalidException: Invalid indirect destination - referenced object 'bm_CR12' cannot be found Offset: 2164791 ID: PDF-HUL-122 ErrorMessage: edu.harvard.hul.ois.jhove.module.pdf.PdfInvalidException: Invalid indirect destination - referenced object 'bm_CR13' cannot be found Offset: 2164791 ID: PDF-HUL-122 ErrorMessage: edu.harvard.hul.ois.jhove.module.pdf.PdfInvalidException: Invalid indirect destination - referenced object 'bm_CR14' cannot be found Offset: 2164791 ID: PDF-HUL-122 ErrorMessage: edu.harvard.hul.ois.jhove.module.pdf.PdfInvalidException: Invalid indirect destination - referenced object 'bm_CR15' cannot be found Offset: 2164791 ID: PDF-HUL-122 ErrorMessage: edu.harvard.hul.ois.jhove.module.pdf.PdfInvalidException: Invalid indirect destination - referenced object 'bm_CR16' cannot be found Offset: 2164791 ID: PDF-HUL-122 ErrorMessage: edu.harvard.hul.ois.jhove.module.pdf.PdfInvalidException: Invalid indirect destination - referenced object 'bm_CR17' cannot be found Offset: 2164791 ID: PDF-HUL-122 ErrorMessage: edu.harvard.hul.ois.jhove.module.pdf.PdfInvalidException: Invalid indirect destination - referenced object 'bm_CR18' cannot be found Offset: 2164791 ID: PDF-HUL-122 ErrorMessage: edu.harvard.hul.ois.jhove.module.pdf.PdfInvalidException: Invalid indirect destination - referenced object 'bm_CR19' cannot be found Offset: 2164791 ID: PDF-HUL-122 ErrorMessage: edu.harvard.hul.ois.jhove.module.pdf.PdfInvalidException: Invalid indirect destination - referenced object 'bm_CR20' cannot be found Offset: 2164791 ID: PDF-HUL-122 ErrorMessage: edu.harvard.hul.ois.jhove.module.pdf.PdfInvalidException: Invalid indirect destination - referenced object 'bm_CR21' cannot be found Offset: 2164791 ID: PDF-HUL-122 ErrorMessage: edu.harvard.hul.ois.jhove.module.pdf.PdfInvalidException: Invalid indirect destination - referenced object 'bm_CR22' cannot be found Offset: 2164791 ID: PDF-HUL-122 ErrorMessage: edu.harvard.hul.ois.jhove.module.pdf.PdfInvalidException: Invalid indirect destination - referenced object 'bm_CR23' cannot be found Offset: 2164791 ID: PDF-HUL-122 ErrorMessage: edu.harvard.hul.ois.jhove.module.pdf.PdfInvalidException: Invalid indirect destination - referenced object 'bm_CR23' cannot be found Offset: 2164791 ID: PDF-HUL-122 ErrorMessage: edu.harvard.hul.ois.jhove.module.pdf.PdfInvalidException: Invalid indirect destination - referenced object 'bm_CR25' cannot be found Offset: 2164791 ID: PDF-HUL-122 ErrorMessage: edu.harvard.hul.ois.jhove.module.pdf.PdfInvalidException: Invalid indirect destination - referenced object 'bm_CR23' cannot be found Offset: 2164791 ID: PDF-HUL-122 ErrorMessage: edu.harvard.hul.ois.jhove.module.pdf.PdfInvalidException: Invalid indirect destination - referenced object 'bm_CR24' cannot be found Offset: 2164791 ID: PDF-HUL-122 ErrorMessage: edu.harvard.hul.ois.jhove.module.pdf.PdfInvalidException: Invalid indirect destination - referenced object 'bm_CR26' cannot be found Offset: 2164791 ID: PDF-HUL-122 ErrorMessage: edu.harvard.hul.ois.jhove.module.pdf.PdfInvalidException: Invalid indirect destination - referenced object 'bm_CR27' cannot be found Offset: 2164791 ID: PDF-HUL-122 ErrorMessage: edu.harvard.hul.ois.jhove.module.pdf.PdfInvalidException: Invalid indirect destination - referenced object 'bm_CR28' cannot be found Offset: 2164791 ID: PDF-HUL-122 ErrorMessage: edu.harvard.hul.ois.jhove.module.pdf.PdfInvalidException: Invalid indirect destination - referenced object 'bm_CR29' cannot be found Offset: 2164791 ID: PDF-HUL-122 ErrorMessage: edu.harvard.hul.ois.jhove.module.pdf.PdfInvalidException: Invalid indirect destination - referenced object 'bm_CR28' cannot be found Offset: 2164791 ID: PDF-HUL-122 ErrorMessage: edu.harvard.hul.ois.jhove.module.pdf.PdfInvalidException: Invalid indirect destination - referenced object 'bm_CR28' cannot be found Offset: 2164791 ID: PDF-HUL-122 ErrorMessage: edu.harvard.hul.ois.jhove.module.pdf.PdfInvalidException: Invalid indirect destination - referenced object 'bm_CR28' cannot be found Offset: 2164791 ID: PDF-HUL-122 ErrorMessage: edu.harvard.hul.ois.jhove.module.pdf.PdfInvalidException: Invalid indirect destination - referenced object 'bm_CR40' cannot be found Offset: 2164791 ID: PDF-HUL-122 ErrorMessage: edu.harvard.hul.ois.jhove.module.pdf.PdfInvalidException: Invalid indirect destination - referenced object 'bm_CR41' cannot be found Offset: 2164791 ID: PDF-HUL-122 ErrorMessage: edu.harvard.hul.ois.jhove.module.pdf.PdfInvalidException: Invalid indirect destination - referenced object 'bm_CR42' cannot be found Offset: 2164791 ID: PDF-HUL-122 ErrorMessage: edu.harvard.hul.ois.jhove.module.pdf.PdfInvalidException: Invalid indirect destination - referenced object 'bm_CR43' cannot be found Offset: 2164791 ID: PDF-HUL-122 ErrorMessage: edu.harvard.hul.ois.jhove.module.pdf.PdfInvalidException: Invalid indirect destination - referenced object 'bm_CR44' cannot be found Offset: 2164791 ID: PDF-HUL-122 ErrorMessage: edu.harvard.hul.ois.jhove.module.pdf.PdfInvalidException: Invalid indirect destination - referenced object 'bm_CR45' cannot be found Offset: 2164791 ID: PDF-HUL-122 ErrorMessage: edu.harvard.hul.ois.jhove.module.pdf.PdfInvalidException: Invalid indirect destination - referenced object 'bm_CR46' cannot be found Offset: 2164791 ID: PDF-HUL-122 ErrorMessage: edu.harvard.hul.ois.jhove.module.pdf.PdfInvalidException: Invalid indirect destination - referenced object 'bm_CR47' cannot be found Offset: 2164791 ID: PDF-HUL-122 ErrorMessage: edu.harvard.hul.ois.jhove.module.pdf.PdfInvalidException: Invalid indirect destination - referenced object 'bm_CR23' cannot be found Offset: 2164791 ID: PDF-HUL-122 ErrorMessage: edu.harvard.hul.ois.jhove.module.pdf.PdfInvalidException: Invalid indirect destination - referenced object 'bm_CR48' cannot be found Offset: 2164791 ID: PDF-HUL-122 ErrorMessage: edu.harvard.hul.ois.jhove.module.pdf.PdfInvalidException: Invalid indirect destination - referenced object 'bm_CR50' cannot be found Offset: 2164791 ID: PDF-HUL-122 ErrorMessage: edu.harvard.hul.ois.jhove.module.pdf.PdfInvalidException: Invalid indirect destination - referenced object 'bm_CR48' cannot be found Offset: 2164791 ID: PDF-HUL-122 ErrorMessage: edu.harvard.hul.ois.jhove.module.pdf.PdfInvalidException: Invalid indirect destination - referenced object 'bm_CR51' cannot be found Offset: 2164791 ID: PDF-HUL-122 ErrorMessage: edu.harvard.hul.ois.jhove.module.pdf.PdfInvalidException: Invalid indirect destination - referenced object 'bm_CR52' cannot be found Offset: 2164791 ID: PDF-HUL-122 ErrorMessage: edu.harvard.hul.ois.jhove.module.pdf.PdfInvalidException: Invalid indirect destination - referenced object 'bm_CR27' cannot be found Offset: 2164791 ID: PDF-HUL-122 ErrorMessage: edu.harvard.hul.ois.jhove.module.pdf.PdfInvalidException: Invalid indirect destination - referenced object 'bm_CR53' cannot be found Offset: 2164791 ID: PDF-HUL-122 ErrorMessage: edu.harvard.hul.ois.jhove.module.pdf.PdfInvalidException: Invalid indirect destination - referenced object 'bm_CR54' cannot be found Offset: 2164791 ID: PDF-HUL-122 ErrorMessage: edu.harvard.hul.ois.jhove.module.pdf.PdfInvalidException: Invalid indirect destination - referenced object 'bm_CR55' cannot be found Offset: 2164791 ID: PDF-HUL-122 ErrorMessage: edu.harvard.hul.ois.jhove.module.pdf.PdfInvalidException: Invalid indirect destination - referenced object 'bm_CR56' cannot be found Offset: 2164791 ID: PDF-HUL-122 ErrorMessage: edu.harvard.hul.ois.jhove.module.pdf.PdfInvalidException: Invalid indirect destination - referenced object 'bm_CR57' cannot be found Offset: 2164791 ID: PDF-HUL-122 ErrorMessage: edu.harvard.hul.ois.jhove.module.pdf.PdfInvalidException: Invalid indirect destination - referenced object 'bm_CR58' cannot be found Offset: 2164791 ID: PDF-HUL-122 ErrorMessage: edu.harvard.hul.ois.jhove.module.pdf.PdfInvalidException: Invalid indirect destination - referenced object 'bm_CR59' cannot be found Offset: 2164791 ID: PDF-HUL-122 ErrorMessage: edu.harvard.hul.ois.jhove.module.pdf.PdfInvalidException: Invalid indirect destination - referenced object 'bm_CR60' cannot be found Offset: 2164791 ID: PDF-HUL-122 ErrorMessage: edu.harvard.hul.ois.jhove.module.pdf.PdfInvalidException: Invalid indirect destination - referenced object 'bm_CR61' cannot be found Offset: 2164791 ID: PDF-HUL-122 ErrorMessage: edu.harvard.hul.ois.jhove.module.pdf.PdfInvalidException: Invalid indirect destination - referenced object 'bm_CR62' cannot be found Offset: 2164791 ID: PDF-HUL-122 ErrorMessage: edu.harvard.hul.ois.jhove.module.pdf.PdfInvalidException: Invalid indirect destination - referenced object 'bm_CR63' cannot be found Offset: 2164791 ID: PDF-HUL-122 ErrorMessage: edu.harvard.hul.ois.jhove.module.pdf.PdfInvalidException: Invalid indirect destination - referenced object 'bm_CR64' cannot be found Offset: 2164791 ID: PDF-HUL-122 ErrorMessage: edu.harvard.hul.ois.jhove.module.pdf.PdfInvalidException: Invalid indirect destination - referenced object 'bm_CR65' cannot be found Offset: 2164791 ID: PDF-HUL-122 ErrorMessage: edu.harvard.hul.ois.jhove.module.pdf.PdfInvalidException: Invalid indirect destination - referenced object 'bm_CR66' cannot be found Offset: 2164791 ID: PDF-HUL-122 ErrorMessage: edu.harvard.hul.ois.jhove.module.pdf.PdfInvalidException: Invalid indirect destination - referenced object 'bm_CR67' cannot be found Offset: 2164791 ID: PDF-HUL-122 ErrorMessage: edu.harvard.hul.ois.jhove.module.pdf.PdfInvalidException: Invalid indirect destination - referenced object 'bm_CR68' cannot be found Offset: 2164791 ID: PDF-HUL-122 ErrorMessage: edu.harvard.hul.ois.jhove.module.pdf.PdfInvalidException: Invalid indirect destination - referenced object 'bm_CR69' cannot be found Offset: 2164791 ID: PDF-HUL-122 ErrorMessage: edu.harvard.hul.ois.jhove.module.pdf.PdfInvalidException: Invalid indirect destination - referenced object 'bm_CR70' cannot be found Offset: 2164791 ID: PDF-HUL-122 ErrorMessage: edu.harvard.hul.ois.jhove.module.pdf.PdfInvalidException: Invalid indirect destination - referenced object 'bm_CR71' cannot be found Offset: 2164791 ID: PDF-HUL-122 ErrorMessage: edu.harvard.hul.ois.jhove.module.pdf.PdfInvalidException: Invalid indirect destination - referenced object 'bm_CR72' cannot be found Offset: 2164791 ID: PDF-HUL-122 ErrorMessage: edu.harvard.hul.ois.jhove.module.pdf.PdfInvalidException: Invalid indirect destination - referenced object 'bm_CR73' cannot be found Offset: 2164791 MIMEtype: application/pdf PDFMetadata: Objects: 1110 FreeObjects: 1 IncrementalUpdates: 0 DocumentCatalog: PageLayout: SinglePage PageMode: UseOutlines Language: EN Outlines: Item: Title: The transcribed pseudogene RPSAP52 enhances the oncofetal HMGA2-IGF2BP2-RAS axis through LIN28B-dependent and independent let-7 inhibition Destination: edu.harvard.hul.ois.jhove.module.pdf.PdfSimpleObject@11758f2a Children: Item: Title: Results Destination: edu.harvard.hul.ois.jhove.module.pdf.PdfSimpleObject@e720b71 Children: Item: Title: RPSAP52 impacts on IGF2BP2 and let-7 in breast cancer cells Destination: edu.harvard.hul.ois.jhove.module.pdf.PdfSimpleObject@1b26f7b2 Item: Title: RPSAP52 has oncogenic-like features in’vitro and in’vivo Destination: edu.harvard.hul.ois.jhove.module.pdf.PdfSimpleObject@491cc5c9 Item: Title: RPSAP52 regulates IGF2BP2/LIN28B/let-7 axis in sarcoma Destination: edu.harvard.hul.ois.jhove.module.pdf.PdfSimpleObject@74ad1f1f Item: Title: RPSAP52 modulates IGF2BP2 binding to its mRNA targets Destination: edu.harvard.hul.ois.jhove.module.pdf.PdfSimpleObject@6a1aab78 Item: Title: RPSAP52 controls IGF2BP2 and mRNA distribution on polysomes Destination: edu.harvard.hul.ois.jhove.module.pdf.PdfSimpleObject@462d5aee Item: Title: RPSAP52 alters key pathways and is a biomarker in sarcoma Destination: edu.harvard.hul.ois.jhove.module.pdf.PdfSimpleObject@69b0fd6f Item: Title: Discussion Destination: edu.harvard.hul.ois.jhove.module.pdf.PdfSimpleObject@757942a1 Item: Title: Methods Destination: edu.harvard.hul.ois.jhove.module.pdf.PdfSimpleObject@4a87761d Children: Item: Title: DNA methylation analysis Destination: edu.harvard.hul.ois.jhove.module.pdf.PdfSimpleObject@66d1af89 Item: Title: Bisulfite genomic sequencing Destination: edu.harvard.hul.ois.jhove.module.pdf.PdfSimpleObject@8646db9 Item: Title: Western blotting Destination: edu.harvard.hul.ois.jhove.module.pdf.PdfSimpleObject@37374a5e Item: Title: Nuclear/cytoplasmic fractionation and poly(A) selection Destination: edu.harvard.hul.ois.jhove.module.pdf.PdfSimpleObject@4671e53b Item: Title: RNA-biotin pull-down Destination: edu.harvard.hul.ois.jhove.module.pdf.PdfSimpleObject@2db7a79b Item: Title: In-gel digestion and LC-MS/MS analysis Destination: edu.harvard.hul.ois.jhove.module.pdf.PdfSimpleObject@6950e31 Item: Title: Reverse pull-down Destination: edu.harvard.hul.ois.jhove.module.pdf.PdfSimpleObject@b7dd107 Item: Title: Cell culture Destination: edu.harvard.hul.ois.jhove.module.pdf.PdfSimpleObject@42eca56e Item: Title: Plasmid construction and transfections Destination: edu.harvard.hul.ois.jhove.module.pdf.PdfSimpleObject@52f759d7 Item: Title: Transcription/translation assay Destination: edu.harvard.hul.ois.jhove.module.pdf.PdfSimpleObject@7cbd213e Item: Title: RNA isolation and RT-qPCR analysis Destination: edu.harvard.hul.ois.jhove.module.pdf.PdfSimpleObject@192d3247 Item: Title: Actinomycin D treatment and RNA stability analysis Destination: edu.harvard.hul.ois.jhove.module.pdf.PdfSimpleObject@3ecd23d9 Item: Title: SRB assay Destination: edu.harvard.hul.ois.jhove.module.pdf.PdfSimpleObject@569cfc36 Item: Title: Colony formation assay Destination: edu.harvard.hul.ois.jhove.module.pdf.PdfSimpleObject@43bd930a Item: Title: Real-time migration assay Destination: edu.harvard.hul.ois.jhove.module.pdf.PdfSimpleObject@33723e30 Item: Title: Transwell migration assay Destination: edu.harvard.hul.ois.jhove.module.pdf.PdfSimpleObject@64f6106c Item: Title: Clonogenicity assay Destination: edu.harvard.hul.ois.jhove.module.pdf.PdfSimpleObject@553a3d88 Item: Title: In vivo xenograft Destination: edu.harvard.hul.ois.jhove.module.pdf.PdfSimpleObject@7a30d1e6 Item: Title: Absolute quantification Destination: edu.harvard.hul.ois.jhove.module.pdf.PdfSimpleObject@5891e32e Item: Title: iCLIP-seq Destination: edu.harvard.hul.ois.jhove.module.pdf.PdfSimpleObject@cb0ed20 Item: Title: iCLIP computational analysis Destination: edu.harvard.hul.ois.jhove.module.pdf.PdfSimpleObject@8e24743 Item: Title: Primary tumors expression and methylation analysis Destination: edu.harvard.hul.ois.jhove.module.pdf.PdfSimpleObject@74a10858 Item: Title: Polysome profile analysis Destination: edu.harvard.hul.ois.jhove.module.pdf.PdfSimpleObject@23fe1d71 Item: Title: IGF2BP2 coimmunoprecipitation and mass spectrometry analysis Destination: edu.harvard.hul.ois.jhove.module.pdf.PdfSimpleObject@28ac3dc3 Item: Title: Expression arrays Destination: edu.harvard.hul.ois.jhove.module.pdf.PdfSimpleObject@32eebfca Item: Title: Statistical analysis Destination: edu.harvard.hul.ois.jhove.module.pdf.PdfSimpleObject@4e718207 Item: Title: Unprocessed scans Destination: edu.harvard.hul.ois.jhove.module.pdf.PdfSimpleObject@1d371b2d Item: Title: Data availability Destination: edu.harvard.hul.ois.jhove.module.pdf.PdfSimpleObject@543c6f6d Item: Title: References Destination: edu.harvard.hul.ois.jhove.module.pdf.PdfSimpleObject@13eb8acf Item: Title: Acknowledgements Destination: edu.harvard.hul.ois.jhove.module.pdf.PdfSimpleObject@51c8530f Item: Title: Author contributions Destination: edu.harvard.hul.ois.jhove.module.pdf.PdfSimpleObject@7403c468 Item: Title: Additional information Destination: edu.harvard.hul.ois.jhove.module.pdf.PdfSimpleObject@43738a82 Info: Title: The transcribed pseudogene RPSAP52 enhances the oncofetal HMGA2-IGF2BP2-RAS axis through LIN28B-dependent and independent let-7 inhibition Author: Cristina Oliveira-Mateos Subject: Nature Communications, doi:10.1038/s41467-019-11910-6 Keywords: Creator: Springer Producer: iText® 5.3.5 ©2000-2012 1T3XT BVBA (AGPL-version) CreationDate: Wed Aug 28 10:56:24 CEST 2019 ModDate: Thu Aug 29 15:52:40 CEST 2019 ID: 0xab08b175ea366247fdd0c4956aa72cd8, 0x57d3ef833be507861dd07e5b9786f22d Filters: FilterPipeline: FlateDecode FilterPipeline: DCTDecode Images: Image: NisoImageMetadata: FormatName: image/png ImageWidth: 416 ImageHeight: 405 BitsPerSample: 8 BitsPerSampleUnit: integer Filter: FlateDecode Image: NisoImageMetadata: FormatName: image/png ImageWidth: 510 ImageHeight: 491 ColorSpace: RGB BitsPerSample: 8 BitsPerSampleUnit: integer Filter: FlateDecode Intent: Perceptual Image: NisoImageMetadata: FormatName: image/png ImageWidth: 98 ImageHeight: 171 BitsPerSample: 8 BitsPerSampleUnit: integer Filter: FlateDecode Image: NisoImageMetadata: FormatName: image/png ImageWidth: 885 ImageHeight: 307 ColorSpace: RGB BitsPerSample: 8 BitsPerSampleUnit: integer Filter: FlateDecode Intent: Perceptual Image: NisoImageMetadata: FormatName: image/png ImageWidth: 1574 ImageHeight: 493 ColorSpace: RGB BitsPerSample: 8 BitsPerSampleUnit: integer Filter: FlateDecode Intent: Perceptual Image: NisoImageMetadata: FormatName: image/png ImageWidth: 599 ImageHeight: 136 BitsPerSample: 8 BitsPerSampleUnit: integer Filter: FlateDecode Image: NisoImageMetadata: FormatName: image/jpg CompressionScheme: JPEG ImageWidth: 181 ImageHeight: 116 BitsPerSample: 8 BitsPerSampleUnit: integer Image: NisoImageMetadata: FormatName: image/png ImageWidth: 610 ImageHeight: 187 BitsPerSample: 8 BitsPerSampleUnit: integer Filter: FlateDecode Image: NisoImageMetadata: FormatName: image/jpg CompressionScheme: JPEG ImageWidth: 602 ImageHeight: 248 BitsPerSample: 8 BitsPerSampleUnit: integer Image: NisoImageMetadata: FormatName: image/jpg CompressionScheme: JPEG ImageWidth: 263 ImageHeight: 226 BitsPerSample: 8 BitsPerSampleUnit: integer Image: NisoImageMetadata: FormatName: image/jpg CompressionScheme: JPEG ImageWidth: 356 ImageHeight: 542 BitsPerSample: 8 BitsPerSampleUnit: integer Image: NisoImageMetadata: FormatName: image/jpg CompressionScheme: JPEG ImageWidth: 171 ImageHeight: 469 BitsPerSample: 8 BitsPerSampleUnit: integer Image: NisoImageMetadata: FormatName: image/jpg CompressionScheme: JPEG ImageWidth: 232 ImageHeight: 217 BitsPerSample: 8 BitsPerSampleUnit: integer Image: NisoImageMetadata: FormatName: image/png ImageWidth: 304 ImageHeight: 103 BitsPerSample: 8 BitsPerSampleUnit: integer Filter: FlateDecode Image: NisoImageMetadata: FormatName: image/jpg CompressionScheme: JPEG ImageWidth: 164 ImageHeight: 367 ColorSpace: RGB BitsPerSample: 8 BitsPerSampleUnit: integer Intent: Perceptual Image: NisoImageMetadata: FormatName: image/png ImageWidth: 446 ImageHeight: 73 BitsPerSample: 8 BitsPerSampleUnit: integer Filter: FlateDecode Image: NisoImageMetadata: FormatName: image/jpg CompressionScheme: JPEG ImageWidth: 207 ImageHeight: 457 ColorSpace: RGB BitsPerSample: 8 BitsPerSampleUnit: integer Intent: Perceptual Image: NisoImageMetadata: FormatName: image/jpg CompressionScheme: JPEG ImageWidth: 488 ImageHeight: 123 ColorSpace: RGB BitsPerSample: 8 BitsPerSampleUnit: integer Intent: Perceptual Image: NisoImageMetadata: FormatName: image/png ImageWidth: 177 ImageHeight: 437 BitsPerSample: 8 BitsPerSampleUnit: integer Filter: FlateDecode Image: NisoImageMetadata: FormatName: image/png ImageWidth: 457 ImageHeight: 60 BitsPerSample: 8 BitsPerSampleUnit: integer Filter: FlateDecode Image: NisoImageMetadata: FormatName: image/png ImageWidth: 462 ImageHeight: 58 BitsPerSample: 8 BitsPerSampleUnit: integer Filter: FlateDecode Image: NisoImageMetadata: FormatName: image/png ImageWidth: 113 ImageHeight: 156 BitsPerSample: 8 BitsPerSampleUnit: integer Filter: FlateDecode Image: NisoImageMetadata: FormatName: image/png ImageWidth: 482 ImageHeight: 485 ColorSpace: RGB BitsPerSample: 8 BitsPerSampleUnit: integer Filter: FlateDecode Intent: Perceptual Image: NisoImageMetadata: FormatName: image/jpg CompressionScheme: JPEG ImageWidth: 389 ImageHeight: 308 ColorSpace: RGB BitsPerSample: 8 BitsPerSampleUnit: integer Intent: Perceptual Image: NisoImageMetadata: FormatName: image/png ImageWidth: 478 ImageHeight: 485 ColorSpace: RGB BitsPerSample: 8 BitsPerSampleUnit: integer Filter: FlateDecode Intent: Perceptual Image: NisoImageMetadata: FormatName: image/jpg CompressionScheme: JPEG ImageWidth: 257 ImageHeight: 95 ColorSpace: RGB BitsPerSample: 8 BitsPerSampleUnit: integer Intent: Perceptual Image: NisoImageMetadata: FormatName: image/png ImageWidth: 848 ImageHeight: 196 BitsPerSample: 8 BitsPerSampleUnit: integer Filter: FlateDecode Image: NisoImageMetadata: FormatName: image/png ImageWidth: 231 ImageHeight: 254 BitsPerSample: 8 BitsPerSampleUnit: integer Filter: FlateDecode Image: NisoImageMetadata: FormatName: image/png ImageWidth: 239 ImageHeight: 355 BitsPerSample: 8 BitsPerSampleUnit: integer Filter: FlateDecode Image: NisoImageMetadata: FormatName: image/png ImageWidth: 660 ImageHeight: 280 ColorSpace: RGB BitsPerSample: 8 BitsPerSampleUnit: integer Filter: FlateDecode Intent: Perceptual Image: NisoImageMetadata: FormatName: image/jpg CompressionScheme: JPEG ImageWidth: 272 ImageHeight: 210 ColorSpace: RGB BitsPerSample: 8 BitsPerSampleUnit: integer Intent: Perceptual Image: NisoImageMetadata: FormatName: image/png ImageWidth: 643 ImageHeight: 287 ColorSpace: RGB BitsPerSample: 8 BitsPerSampleUnit: integer Filter: FlateDecode Intent: Perceptual Image: NisoImageMetadata: FormatName: image/png ImageWidth: 540 ImageHeight: 99 BitsPerSample: 8 BitsPerSampleUnit: integer Filter: FlateDecode Image: NisoImageMetadata: FormatName: image/png ImageWidth: 132 ImageHeight: 114 BitsPerSample: 8 BitsPerSampleUnit: integer Filter: FlateDecode Image: NisoImageMetadata: FormatName: image/png ImageWidth: 570 ImageHeight: 368 BitsPerSample: 8 BitsPerSampleUnit: integer Filter: FlateDecode Image: NisoImageMetadata: FormatName: image/png ImageWidth: 702 ImageHeight: 181 ColorSpace: RGB BitsPerSample: 8 BitsPerSampleUnit: integer Filter: FlateDecode Intent: Perceptual Image: NisoImageMetadata: FormatName: image/png ImageWidth: 287 ImageHeight: 112 BitsPerSample: 8 BitsPerSampleUnit: integer Filter: FlateDecode Image: NisoImageMetadata: FormatName: image/jpg CompressionScheme: JPEG ImageWidth: 662 ImageHeight: 292 ColorSpace: RGB BitsPerSample: 8 BitsPerSampleUnit: integer Intent: Perceptual Image: NisoImageMetadata: FormatName: image/jpg CompressionScheme: JPEG ImageWidth: 657 ImageHeight: 301 ColorSpace: RGB BitsPerSample: 8 BitsPerSampleUnit: integer Intent: Perceptual Image: NisoImageMetadata: FormatName: image/jpg CompressionScheme: JPEG ImageWidth: 657 ImageHeight: 294 ColorSpace: RGB BitsPerSample: 8 BitsPerSampleUnit: integer Intent: Perceptual Image: NisoImageMetadata: FormatName: image/jpg CompressionScheme: JPEG ImageWidth: 658 ImageHeight: 298 ColorSpace: RGB BitsPerSample: 8 BitsPerSampleUnit: integer Intent: Perceptual Image: NisoImageMetadata: FormatName: image/jpg CompressionScheme: JPEG ImageWidth: 669 ImageHeight: 355 ColorSpace: RGB BitsPerSample: 8 BitsPerSampleUnit: integer Intent: Perceptual Image: NisoImageMetadata: FormatName: image/png ImageWidth: 324 ImageHeight: 440 ColorSpace: RGB BitsPerSample: 8 BitsPerSampleUnit: integer Filter: FlateDecode Intent: Perceptual Image: NisoImageMetadata: FormatName: image/png ImageWidth: 247 ImageHeight: 308 ColorSpace: RGB BitsPerSample: 8 BitsPerSampleUnit: integer Filter: FlateDecode Intent: Perceptual Image: NisoImageMetadata: FormatName: image/jpg CompressionScheme: JPEG ImageWidth: 467 ImageHeight: 481 ColorSpace: RGB BitsPerSample: 8 BitsPerSampleUnit: integer Intent: Perceptual Image: NisoImageMetadata: FormatName: image/jpg CompressionScheme: JPEG ImageWidth: 493 ImageHeight: 511 ColorSpace: RGB BitsPerSample: 8 BitsPerSampleUnit: integer Intent: Perceptual Image: NisoImageMetadata: FormatName: image/png ImageWidth: 241 ImageHeight: 300 ColorSpace: RGB BitsPerSample: 8 BitsPerSampleUnit: integer Filter: FlateDecode Intent: Perceptual Image: NisoImageMetadata: FormatName: image/jpg CompressionScheme: JPEG ImageWidth: 467 ImageHeight: 481 ColorSpace: RGB BitsPerSample: 8 BitsPerSampleUnit: integer Intent: Perceptual Image: NisoImageMetadata: FormatName: image/jpg CompressionScheme: JPEG ImageWidth: 544 ImageHeight: 531 ColorSpace: RGB BitsPerSample: 8 BitsPerSampleUnit: integer Intent: Perceptual Image: NisoImageMetadata: FormatName: image/png ImageWidth: 1100 ImageHeight: 90 ColorSpace: black is zero BitsPerSample: 1 BitsPerSampleUnit: integer Filter: FlateDecode Fonts: Type1: Font: BaseFont: DKLGNF+AdvOT9bd21c25.I FontSubset: true FirstChar: 45 LastChar: 121 FontDescriptor: FontName: DKLGNF+AdvOT9bd21c25.I Flags: Nonsymbolic FontBBox: -83, -197, 1010, 906 FontFile3: true Encoding: WinAnsiEncoding Font: BaseFont: DKLKNO+AdvOTea1a7398+fb FontSubset: true FirstChar: 1 LastChar: 3 FontDescriptor: FontName: DKLKNO+AdvOTea1a7398+fb Flags: Symbolic FontBBox: 0, -197, 750, 791 FontFile3: true EncodingDictionary: Differences: true ToUnicode: true Font: BaseFont: DKMEKE+AdvOT8608a8d1+20 FontSubset: true FirstChar: 1 LastChar: 1 FontDescriptor: FontName: DKMEKE+AdvOT8608a8d1+20 Flags: Symbolic FontBBox: -968, -333, 2000, 1020 FontFile3: true EncodingDictionary: Differences: true ToUnicode: true Font: BaseFont: DKMELF+AdvTTab7e17fd+22 FontSubset: true FirstChar: 21 LastChar: 21 FontDescriptor: FontName: DKMELF+AdvTTab7e17fd+22 Flags: Nonsymbolic FontBBox: -156, -218, 937, 947 FontFile3: true EncodingDictionary: BaseEncoding: WinAnsiEncoding Differences: true Font: BaseFont: DKODIP+AdvTT7b515deb FontSubset: true FirstChar: 174 LastChar: 174 FontDescriptor: FontName: DKODIP+AdvTT7b515deb Flags: Nonsymbolic FontBBox: -93, -187, 854, 843 FontFile3: true Encoding: WinAnsiEncoding Font: BaseFont: DKODHO+AdvOTcb88df00+fb FontSubset: true FirstChar: 1 LastChar: 1 FontDescriptor: FontName: DKODHO+AdvOTcb88df00+fb Flags: Symbolic FontBBox: 0, -197, 895, 791 FontFile3: true EncodingDictionary: Differences: true ToUnicode: true Font: BaseFont: DKODIO+AdvOT1ef757c0+03 FontSubset: true FirstChar: 1 LastChar: 6 FontDescriptor: FontName: DKODIO+AdvOT1ef757c0+03 Flags: Symbolic FontBBox: -125, -270, 854, 791 FontFile3: true EncodingDictionary: Differences: true ToUnicode: true Font: BaseFont: DKMDLJ+Helvetica-Bold FontSubset: true FirstChar: 97 LastChar: 104 FontDescriptor: FontName: DKMDLJ+Helvetica-Bold Flags: Nonsymbolic, ForceBold FontBBox: -170, -228, 1003, 962 FontFile3: true Encoding: WinAnsiEncoding Font: BaseFont: DKMDFJ+Helvetica-Oblique FontSubset: true FirstChar: 32 LastChar: 150 FontDescriptor: FontName: DKMDFJ+Helvetica-Oblique Flags: Nonsymbolic, Italic FontBBox: -170, -225, 1116, 931 FontFile3: true Encoding: WinAnsiEncoding Font: BaseFont: DKMDGK+Symbol FontSubset: true FirstChar: 2 LastChar: 4 FontDescriptor: FontName: DKMDGK+Symbol Flags: Symbolic FontBBox: -180, -293, 1090, 1010 FontFile3: true EncodingDictionary: Differences: true ToUnicode: true Font: BaseFont: DKMCKM+Helvetica FontSubset: true FirstChar: 32 LastChar: 150 FontDescriptor: FontName: DKMCKM+Helvetica Flags: Nonsymbolic FontBBox: -166, -225, 1000, 931 FontFile3: true Encoding: WinAnsiEncoding Font: BaseFont: DKOKEH+AdvOT1ef757c0+21 FontSubset: true FirstChar: 153 LastChar: 153 FontDescriptor: FontName: DKOKEH+AdvOT1ef757c0+21 Flags: Nonsymbolic FontBBox: 0, -20, 822, 697 FontFile3: true Encoding: WinAnsiEncoding Font: BaseFont: DKOMCB+AdvOTb65e897d.B+20 FontSubset: true FirstChar: 146 LastChar: 146 FontDescriptor: FontName: DKOMCB+AdvOTb65e897d.B+20 Flags: Nonsymbolic FontBBox: -125, -177, 1052, 822 FontFile3: true Encoding: WinAnsiEncoding Font: BaseFont: DKOMCA+AdvOT7d6df7ab.I+fb FontSubset: true FirstChar: 1 LastChar: 1 FontDescriptor: FontName: DKOMCA+AdvOT7d6df7ab.I+fb Flags: Symbolic FontBBox: -156, -250, 802, 708 FontFile3: true EncodingDictionary: Differences: true ToUnicode: true Font: BaseFont: Arial-BoldMT FirstChar: 0 LastChar: 255 FontDescriptor: FontName: Arial-BoldMT Flags: Nonsymbolic FontBBox: -628, -376, 2000, 1010 FontFile3: true Encoding: WinAnsiEncoding Font: BaseFont: DKLLDO+AdvOTf23bb480 FontSubset: true FirstChar: 40 LastChar: 243 FontDescriptor: FontName: DKLLDO+AdvOTf23bb480 Flags: Nonsymbolic FontBBox: -31, -197, 968, 916 FontFile3: true Encoding: WinAnsiEncoding Font: BaseFont: DKLLDP+AdvOTf23bb480+20 FontSubset: true FirstChar: 146 LastChar: 146 FontDescriptor: FontName: DKLLDP+AdvOTf23bb480+20 Flags: Nonsymbolic FontBBox: -93, -197, 843, 791 FontFile3: true Encoding: WinAnsiEncoding Font: BaseFont: DKOLBF+AdvOT7d6df7ab.I+20 FontSubset: true FirstChar: 150 LastChar: 150 FontDescriptor: FontName: DKOLBF+AdvOT7d6df7ab.I+20 Flags: Nonsymbolic FontBBox: -156, -187, 1000, 822 FontFile3: true Encoding: WinAnsiEncoding Font: BaseFont: DKOKPF+AdvTT3f84ef53 FontSubset: true FirstChar: 180 LastChar: 180 FontDescriptor: FontName: DKOKPF+AdvTT3f84ef53 Flags: Nonsymbolic FontBBox: 0, -218, 1104, 1000 FontFile3: true Encoding: WinAnsiEncoding Font: BaseFont: DKOKPE+AdvP4C4E74 FontSubset: true FirstChar: 188 LastChar: 188 FontDescriptor: FontName: DKOKPE+AdvP4C4E74 Flags: Nonsymbolic FontBBox: -20, -958, 1114, 770 FontFile3: true Encoding: WinAnsiEncoding Font: BaseFont: DKLGNE+AdvOTea1a7398 FontSubset: true FirstChar: 35 LastChar: 250 FontDescriptor: FontName: DKLGNE+AdvOTea1a7398 Flags: Nonsymbolic FontBBox: -31, -197, 979, 906 FontFile3: true Encoding: WinAnsiEncoding Font: BaseFont: DKLLLP+AdvOT1ef757c0 FontSubset: true FirstChar: 35 LastChar: 252 FontDescriptor: FontName: DKLLLP+AdvOT1ef757c0 Flags: Serif, Nonsymbolic FontBBox: -20, -250, 947, 854 FontFile3: true Encoding: WinAnsiEncoding Font: BaseFont: DKLKOO+AdvOTcb88df00 FontSubset: true FirstChar: 40 LastChar: 121 FontDescriptor: FontName: DKLKOO+AdvOTcb88df00 Flags: Nonsymbolic FontBBox: -41, -197, 968, 906 FontFile3: true Encoding: WinAnsiEncoding Font: BaseFont: DKLLNA+AdvOT1ef757c0+fb FontSubset: true FirstChar: 1 LastChar: 3 FontDescriptor: FontName: DKLLNA+AdvOT1ef757c0+fb Flags: Symbolic FontBBox: 0, -10, 781, 708 FontFile3: true EncodingDictionary: Differences: true ToUnicode: true Font: BaseFont: DKLLOD+AdvOTb65e897d.B FontSubset: true FirstChar: 45 LastChar: 121 FontDescriptor: FontName: DKLLOD+AdvOTb65e897d.B Flags: Serif, Nonsymbolic FontBBox: -20, -250, 968, 854 FontFile3: true Encoding: WinAnsiEncoding Font: BaseFont: DKLLLO+AdvOT125c650c FontSubset: true FirstChar: 84 LastChar: 84 FontDescriptor: FontName: DKLLLO+AdvOT125c650c Flags: Nonsymbolic FontBBox: -31, -197, 979, 906 FontFile3: true Encoding: WinAnsiEncoding Font: BaseFont: DKLLPD+AdvOT1ef757c0+20 FontSubset: true FirstChar: 133 LastChar: 151 FontDescriptor: FontName: DKLLPD+AdvOT1ef757c0+20 Flags: Nonsymbolic FontBBox: -135, -187, 1010, 833 FontFile3: true Encoding: WinAnsiEncoding Font: BaseFont: DKLLFA+AdvTTda6f6cb8.B FontSubset: true FirstChar: 48 LastChar: 57 FontDescriptor: FontName: DKLLFA+AdvTTda6f6cb8.B Flags: Nonsymbolic FontBBox: -72, -218, 895, 927 FontFile3: true Encoding: WinAnsiEncoding Font: BaseFont: DKLLNB+AdvOT7d6df7ab.I FontSubset: true FirstChar: 45 LastChar: 243 FontDescriptor: FontName: DKLLNB+AdvOT7d6df7ab.I Flags: Serif, Nonsymbolic FontBBox: -135, -250, 1000, 854 FontFile3: true Encoding: WinAnsiEncoding Font: BaseFont: DKLLOC+AdvOT45bf69de.BI FontSubset: true FirstChar: 45 LastChar: 116 FontDescriptor: FontName: DKLLOC+AdvOT45bf69de.BI Flags: Serif, Nonsymbolic FontBBox: -135, -250, 1010, 864 FontFile3: true Encoding: WinAnsiEncoding Font: BaseFont: DKLMAE+AdvTTab7e17fd FontSubset: true FirstChar: 43 LastChar: 61 FontDescriptor: FontName: DKLMAE+AdvTTab7e17fd Flags: Nonsymbolic FontBBox: -156, -250, 1072, 947 FontFile3: true Encoding: WinAnsiEncoding Font: BaseFont: DKNNIB+AdvOT7d6df7ab.I+03 FontSubset: true FirstChar: 1 LastChar: 3 FontDescriptor: FontName: DKNNIB+AdvOT7d6df7ab.I+03 Flags: Symbolic FontBBox: -62, -270, 906, 781 FontFile3: true EncodingDictionary: Differences: true ToUnicode: true Font: BaseFont: DKNABB+AdvOT8608a8d1+22 FontSubset: true FirstChar: 1 LastChar: 1 FontDescriptor: FontName: DKNABB+AdvOT8608a8d1+22 Flags: Symbolic FontBBox: 0, -322, 1218, 968 FontFile3: true EncodingDictionary: Differences: true ToUnicode: true Font: BaseFont: DKNACC+AdvOTea1a7398+20 FontSubset: true FirstChar: 146 LastChar: 150 FontDescriptor: FontName: DKNACC+AdvOTea1a7398+20 Flags: Nonsymbolic FontBBox: -93, -197, 843, 791 FontFile3: true Encoding: WinAnsiEncoding Font: BaseFont: DKNACD+AdvOT8608a8d1 FontSubset: true FirstChar: 181 LastChar: 181 FontDescriptor: FontName: DKNACD+AdvOT8608a8d1 Flags: Nonsymbolic FontBBox: -62, -208, 927, 958 FontFile3: true Encoding: WinAnsiEncoding Font: BaseFont: Helvetica2 FirstChar: 32 LastChar: 121 FontDescriptor: FontName: Helvetica2 Flags: Nonsymbolic FontBBox: -166, -225, 1000, 931 FontFile3: true Encoding: WinAnsiEncoding XMP: application/pdf doi:10.1038/s41467-019-11910-6 The transcribed pseudogene RPSAP52 enhances the oncofetal HMGA2-IGF2BP2-RAS axis through LIN28B-dependent and independent let-7 inhibition Cristina Oliveira-Mateos Anaís Sánchez-Castillo Marta Soler Aida Obiols-Guardia David Piñeyro Raquel Boque-Sastre Maria E. Calleja-Cervantes Manuel Castro de Moura Anna Martínez-Cardús Teresa Rubio Joffrey Pelletier Maria Martínez-Iniesta David Herrero-Martín Oscar M. Tirado Antonio Gentilella Alberto Villanueva Manel Esteller Lourdes Farré Sonia Guil Springer US Nature Communications, doi:10.1038/s41467-019-11910-6 10.1038/s41467-019-11910-6 http://dx.doi.org/10.1038/s41467-019-11910-6 journal Nature Communications © 2019, The Author(s) 2041-1723 10.1038/s41467-019-11910-6 springer.com springerlink.com 2010-04-23 True 10.1038/s41467-019-11910-6 springer.com springerlink.com Springer 2019-08-29T15:52:40+02:00 2019-08-28T13:56:24+05:30 2019-08-29T15:52:40+02:00 True iText® 5.3.5 ©2000-2012 1T3XT BVBA (AGPL-version) VoR uuid:1aee0a42-3e07-4c20-aab5-caa76fca8214 uuid:f7e76a03-e18f-441d-847f-262e2f2e3c70 default 1 converted uuid:d3a6fe40-97e4-4b47-8a3d-31223c7a6eee converted to PDF/A-2b pdfToolbox 2019-08-28T13:57:36+05:30 2 B Marta Soler http://orcid.org/0000-0002-6656-957X David Piñeyro http://orcid.org/0000-0001-5633-3339 Raquel Boque-Sastre http://orcid.org/0000-0002-0214-8848 Anna Martínez-Cardús http://orcid.org/0000-0002-3937-8794 Joffrey Pelletier http://orcid.org/0000-0001-9174-044X David Herrero-Martín http://orcid.org/0000-0001-6548-6812 Oscar M. Tirado http://orcid.org/0000-0002-4666-2822 Antonio Gentilella http://orcid.org/0000-0002-6830-2086 Manel Esteller http://orcid.org/0000-0003-4490-6093 Sonia Guil http://orcid.org/0000-0002-2257-3331 http://ns.adobe.com/pdf/1.3/ pdf Adobe PDF Schema internal A name object indicating whether the document has been modified to include trapping information Trapped Text http://ns.adobe.com/pdfx/1.3/ pdfx pdfx internal ID of PDF/X standard GTS_PDFXVersion Text internal Conformance level of PDF/X standard GTS_PDFXConformance Text internal Company creating the PDF Company Text internal Date when document was last modified SourceModified Text external Mirrors crossmark:CrosMarkDomains CrossMarkDomains Seq Text internal Mirrors crossmark:DOI doi Text http://ns.adobe.com/xap/1.0/mm/ xmpMM XMP Media Management Schema internal UUID based identifier for specific incarnation of a document InstanceID URI internal The common identifier for all versions and renditions of a document. OriginalDocumentID URI http://www.aiim.org/pdfa/ns/id/ pdfaid PDF/A ID Schema internal Part of PDF/A standard part Integer internal Amendment of PDF/A standard amd Text internal Conformance level of PDF/A standard conformance Text http://crossref.org/crossmark/1.0/ crossmark crossmark internal CrossMarkDomains CrossMarkDomains Seq Text internal CrossmarkDomainExclusive CrossmarkDomainExclusive Text internal Usual same as prism:doi DOI Text external The date when a publication was published. MajorVersionDate Text http://prismstandard.org/namespaces/basic/2.0/ prism Prism external The aggregation type specifies the unit of aggregation for a content collection. Comment PRISM recommends that the PRISM Aggregation Type Controlled Vocabulary be used to provide values for this element. Note: PRISM recommends against the use of the #other value currently allowed in this controlled vocabulary. In lieu of using #other please reach out to the PRISM group at info@prismstandard.org to request addition of your term to the Aggregation Type Controlled Vocabulary. aggregationType Text external Copyright copyright Text external The Digital Object Identifier for the article. The DOI may also be used as the dc:identifier. If used as a dc:identifier, the URI form should be captured, and the bare identifier should also be captured using prism:doi. If an alternate unique identifier is used as the required dc:identifier, then the DOI should be specified as a bare identifier within prism:doi only. If the URL associated with a DOI is to be specified, then prism:url may be used in conjunction with prism:doi in order to provide the service endpoint (i.e. the URL). doi Text external ISSN for an electronic version of the issue in which the resource occurs. Permits publishers to include a second ISSN, identifying an electronic version of the issue in which the resource occurs (therefore e(lectronic)Issn. If used, prism:eIssn MUST contain the ISSN of the electronic version. See prism:issn. issn Text external Title of the magazine, or other publication, in which a resource was/will be published. Typically this will be used to provide the name of the magazine an article appeared in as metadata for the article, along with information such as the article title, the publisher, volume, number, and cover date. Note: Publication name can be used to differentiate between a print magazine and the online version if the names are different such as “magazine” and “magazine.com.” publicationName Text external This element provides the url for an article or unit of content. The attribute platform is optionally allowed for situations in which multiple URLs must be specified. PRISM recommends that a subset of the PCV platform values, namely “mobile” and “web”, be used in conjunction with this element. NOTE: PRISM recommends against the use of the #other value allowed in the PRISM Platform controlled vocabulary. In lieu of using #other please reach out to the PRISM group at prism-wg@yahoogroups.com to request addition of your term to the Platform Controlled Vocabulary. url Text http://springernature.com/ns/xmpExtensions/2.0/ sn Springer Nature ORCID Schema external Author information: contains the name of each author and his/her ORCID (ORCiD: Open Researcher and Contributor ID). An ORCID is a persistent identifier (a non-proprietary alphanumeric code) to uniquely identify scientific and other academic authors. authorInfo Bag AuthorInformation Specifies the types of author information: name and ORCID of an author. http://springernature.com/ns/xmpExtensions/2.0/authorInfo/ author AuthorInformation Gives the name of an author. name Text Gives the ORCID of an author. orcid URI http://www.niso.org/schemas/jav/1.0/ jav NISO external Values for Journal Article Version are one of the following: AO = Author’s Original SMUR = Submitted Manuscript Under Review AM = Accepted Manuscript P = Proof VoR = Version of Record CVoR = Corrected Version of Record EVoR = Enhanced Version of Record journal_article_version Closed Choice of Text Pages: Page: Label: 1 Annotations: Annotation: Subtype: Link Rect: 339, 513, 340, 524 Flags: Print AppearanceDictionary: true Annotation: Subtype: Link Rect: 339, 513, 340, 524 Flags: Print AppearanceDictionary: true Annotation: Subtype: Link Rect: 348, 513, 349, 524 Flags: Print AppearanceDictionary: true Annotation: Subtype: Link Rect: 338, 513, 349, 524 Flags: Print AppearanceDictionary: true Annotation: Subtype: Link Rect: 349, 513, 352, 524 Flags: Print AppearanceDictionary: true Annotation: Subtype: Link Rect: 527, 513, 528, 524 Flags: Print AppearanceDictionary: true Annotation: Subtype: Link Rect: 527, 513, 528, 524 Flags: Print AppearanceDictionary: true Annotation: Subtype: Link Rect: 536, 513, 537, 524 Flags: Print AppearanceDictionary: true Annotation: Subtype: Link Rect: 526, 513, 537, 524 Flags: Print AppearanceDictionary: true Annotation: Subtype: Link Rect: 537, 513, 540, 524 Flags: Print AppearanceDictionary: true Annotation: Subtype: Link Rect: 138, 497, 139, 508 Flags: Print AppearanceDictionary: true Annotation: Subtype: Link Rect: 138, 497, 139, 508 Flags: Print AppearanceDictionary: true Annotation: Subtype: Link Rect: 147, 497, 148, 508 Flags: Print AppearanceDictionary: true Annotation: Subtype: Link Rect: 137, 497, 148, 508 Flags: Print AppearanceDictionary: true Annotation: Subtype: Link Rect: 148, 497, 150, 508 Flags: Print AppearanceDictionary: true Annotation: Subtype: Link Rect: 528, 497, 529, 508 Flags: Print AppearanceDictionary: true Annotation: Subtype: Link Rect: 528, 497, 529, 508 Flags: Print AppearanceDictionary: true Annotation: Subtype: Link Rect: 537, 497, 538, 508 Flags: Print AppearanceDictionary: true Annotation: Subtype: Link Rect: 527, 497, 538, 508 Flags: Print AppearanceDictionary: true Annotation: Subtype: Link Rect: 538, 497, 541, 508 Flags: Print AppearanceDictionary: true Annotation: Subtype: Link Rect: 185, 481, 186, 492 Flags: Print AppearanceDictionary: true Annotation: Subtype: Link Rect: 185, 481, 186, 492 Flags: Print AppearanceDictionary: true Annotation: Subtype: Link Rect: 194, 481, 195, 492 Flags: Print AppearanceDictionary: true Annotation: Subtype: Link Rect: 184, 481, 195, 492 Flags: Print AppearanceDictionary: true Annotation: Subtype: Link Rect: 195, 481, 197, 492 Flags: Print AppearanceDictionary: true Annotation: Subtype: Link Rect: 424, 481, 425, 492 Flags: Print AppearanceDictionary: true Annotation: Subtype: Link Rect: 424, 481, 425, 492 Flags: Print AppearanceDictionary: true Annotation: Subtype: Link Rect: 433, 481, 434, 492 Flags: Print AppearanceDictionary: true Annotation: Subtype: Link Rect: 423, 481, 434, 492 Flags: Print AppearanceDictionary: true Annotation: Subtype: Link Rect: 434, 481, 437, 492 Flags: Print AppearanceDictionary: true Annotation: Subtype: Link Rect: 523, 481, 524, 492 Flags: Print AppearanceDictionary: true Annotation: Subtype: Link Rect: 523, 481, 524, 492 Flags: Print AppearanceDictionary: true Annotation: Subtype: Link Rect: 532, 481, 533, 492 Flags: Print AppearanceDictionary: true Annotation: Subtype: Link Rect: 522, 481, 533, 492 Flags: Print AppearanceDictionary: true Annotation: Subtype: Link Rect: 533, 481, 536, 492 Flags: Print AppearanceDictionary: true Annotation: Subtype: Link Rect: 126, 465, 127, 476 Flags: Print AppearanceDictionary: true Annotation: Subtype: Link Rect: 126, 465, 127, 476 Flags: Print AppearanceDictionary: true Annotation: Subtype: Link Rect: 135, 465, 136, 476 Flags: Print AppearanceDictionary: true Annotation: Subtype: Link Rect: 125, 465, 136, 476 Flags: Print AppearanceDictionary: true Annotation: Subtype: Link Rect: 136, 465, 138, 476 Flags: Print AppearanceDictionary: true Annotation: Subtype: Link Rect: 317, 465, 318, 476 Flags: Print AppearanceDictionary: true Annotation: Subtype: Link Rect: 317, 465, 318, 476 Flags: Print AppearanceDictionary: true Annotation: Subtype: Link Rect: 326, 465, 327, 476 Flags: Print AppearanceDictionary: true Annotation: Subtype: Link Rect: 317, 465, 327, 476 Flags: Print AppearanceDictionary: true Annotation: Subtype: Link Rect: 327, 465, 330, 476 Flags: Print AppearanceDictionary: true Annotation: Subtype: Link Rect: 507, 465, 508, 476 Flags: Print AppearanceDictionary: true Annotation: Subtype: Link Rect: 507, 465, 508, 476 Flags: Print AppearanceDictionary: true Annotation: Subtype: Link Rect: 516, 465, 517, 476 Flags: Print AppearanceDictionary: true Annotation: Subtype: Link Rect: 506, 465, 517, 476 Flags: Print AppearanceDictionary: true Annotation: Subtype: Link Rect: 517, 465, 519, 476 Flags: Print AppearanceDictionary: true Annotation: Subtype: Link Rect: 456, 53, 515, 61 Flags: Print AppearanceDictionary: true Annotation: Subtype: Link Rect: 102, 43, 190, 51 Flags: Print AppearanceDictionary: true Annotation: Subtype: Link Rect: 369, 23, 484, 30 Flags: Print AppearanceDictionary: true Annotation: Subtype: Link Rect: 547, 23, 551, 30 Flags: Print AppearanceDictionary: true Thumb: true Page: Label: 2 Annotations: Annotation: Subtype: Link Rect: 186, 705, 190, 712 Flags: Print AppearanceDictionary: true Destination: 607 Annotation: Subtype: Link Rect: 267, 642, 271, 649 Flags: Print AppearanceDictionary: true Destination: 607 Annotation: Subtype: Link Rect: 273, 642, 276, 649 Flags: Print AppearanceDictionary: true Destination: 607 Annotation: Subtype: Link Rect: 132, 610, 136, 618 Flags: Print AppearanceDictionary: true Destination: 607 Annotation: Subtype: Link Rect: 226, 590, 229, 597 Flags: Print AppearanceDictionary: true Destination: 607 Annotation: Subtype: Link Rect: 285, 590, 289, 597 Flags: Print AppearanceDictionary: true Destination: 607 Annotation: Subtype: Link Rect: 68, 579, 72, 587 Flags: Print AppearanceDictionary: true Destination: 607 Annotation: Subtype: Link Rect: 237, 579, 240, 587 Flags: Print AppearanceDictionary: true Destination: 607 Annotation: Subtype: Link Rect: 285, 579, 289, 587 Flags: Print AppearanceDictionary: true Destination: 607 Annotation: Subtype: Link Rect: 79, 569, 86, 576 Flags: Print AppearanceDictionary: true Destination: null Annotation: Subtype: Link Rect: 258, 569, 266, 576 Flags: Print AppearanceDictionary: true Destination: null Annotation: Subtype: Link Rect: 176, 558, 184, 566 Flags: Print AppearanceDictionary: true Destination: null Annotation: Subtype: Link Rect: 218, 558, 225, 566 Flags: Print AppearanceDictionary: true Destination: null Annotation: Subtype: Link Rect: 172, 516, 179, 524 Flags: Print AppearanceDictionary: true Destination: null Annotation: Subtype: Link Rect: 181, 516, 188, 524 Flags: Print AppearanceDictionary: true Destination: null Annotation: Subtype: Link Rect: 107, 495, 115, 503 Flags: Print AppearanceDictionary: true Destination: null Annotation: Subtype: Link Rect: 272, 495, 279, 503 Flags: Print AppearanceDictionary: true Destination: null Annotation: Subtype: Link Rect: 240, 485, 247, 493 Flags: Print AppearanceDictionary: true Destination: null Annotation: Subtype: Link Rect: 153, 450, 291, 460 Flags: Print AppearanceDictionary: true Annotation: Subtype: Link Rect: 43, 440, 95, 449 Flags: Print AppearanceDictionary: true Annotation: Subtype: Link Rect: 245, 401, 252, 409 Flags: Print AppearanceDictionary: true Destination: null Annotation: Subtype: Link Rect: 267, 391, 274, 398 Flags: Print AppearanceDictionary: true Destination: null Annotation: Subtype: Link Rect: 216, 328, 223, 336 Flags: Print AppearanceDictionary: true Destination: null Annotation: Subtype: Link Rect: 225, 328, 232, 336 Flags: Print AppearanceDictionary: true Destination: null Annotation: Subtype: Link Rect: 282, 307, 289, 315 Flags: Print AppearanceDictionary: true Destination: null Annotation: Subtype: Link Rect: 101, 189, 105, 198 Flags: Print AppearanceDictionary: true Destination: 155 Annotation: Subtype: Link Rect: 112, 192, 119, 200 Flags: Print AppearanceDictionary: true Destination: null Annotation: Subtype: Link Rect: 266, 157, 270, 167 Flags: Print AppearanceDictionary: true Destination: 155 Annotation: Subtype: Link Rect: 174, 136, 179, 146 Flags: Print AppearanceDictionary: true Destination: 155 Annotation: Subtype: Link Rect: 130, 108, 137, 116 Flags: Print AppearanceDictionary: true Destination: null Annotation: Subtype: Link Rect: 82, 87, 89, 95 Flags: Print AppearanceDictionary: true Destination: null Annotation: Subtype: Link Rect: 243, 53, 248, 62 Flags: Print AppearanceDictionary: true Destination: 155 Annotation: Subtype: Link Rect: 347, 701, 351, 711 Flags: Print AppearanceDictionary: true Destination: 155 Annotation: Subtype: Link Rect: 465, 684, 472, 691 Flags: Print AppearanceDictionary: true Destination: null Annotation: Subtype: Link Rect: 432, 670, 529, 679 Flags: Print AppearanceDictionary: true Annotation: Subtype: Link Rect: 354, 607, 359, 617 Flags: Print AppearanceDictionary: true Destination: 155 Annotation: Subtype: Link Rect: 496, 429, 501, 439 Flags: Print AppearanceDictionary: true Destination: 155 Annotation: Subtype: Link Rect: 366, 419, 370, 428 Flags: Print AppearanceDictionary: true Destination: 155 Annotation: Subtype: Link Rect: 303, 346, 308, 355 Flags: Print AppearanceDictionary: true Destination: 207 Annotation: Subtype: Link Rect: 453, 234, 460, 241 Flags: Print AppearanceDictionary: true Destination: null Annotation: Subtype: Link Rect: 441, 192, 448, 200 Flags: Print AppearanceDictionary: true Destination: null Annotation: Subtype: Link Rect: 366, 147, 370, 156 Flags: Print AppearanceDictionary: true Destination: 207 Annotation: Subtype: Link Rect: 414, 129, 421, 137 Flags: Print AppearanceDictionary: true Destination: null Annotation: Subtype: Link Rect: 525, 87, 533, 95 Flags: Print AppearanceDictionary: true Destination: null Annotation: Subtype: Link Rect: 513, 77, 520, 85 Flags: Print AppearanceDictionary: true Destination: 607 Annotation: Subtype: Link Rect: 522, 77, 529, 85 Flags: Print AppearanceDictionary: true Destination: 607 Annotation: Subtype: Link Rect: 436, 23, 551, 30 Flags: Print AppearanceDictionary: true Thumb: true Page: Label: 3 Annotations: Annotation: Subtype: Link Rect: 226, 78, 233, 85 Flags: Print AppearanceDictionary: true Destination: 607 Annotation: Subtype: Link Rect: 234, 78, 242, 85 Flags: Print AppearanceDictionary: true Destination: 607 Annotation: Subtype: Link Rect: 543, 75, 547, 84 Flags: Print AppearanceDictionary: true Destination: 207 Annotation: Subtype: Link Rect: 451, 43, 456, 53 Flags: Print AppearanceDictionary: true Destination: 207 Annotation: Subtype: Link Rect: 369, 23, 484, 30 Flags: Print AppearanceDictionary: true Annotation: Subtype: Link Rect: 547, 23, 551, 30 Flags: Print AppearanceDictionary: true Thumb: true Page: Label: 4 Annotations: Annotation: Subtype: Link Rect: 43, 432, 48, 441 Flags: Print AppearanceDictionary: true Destination: 207 Annotation: Subtype: Link Rect: 90, 390, 94, 399 Flags: Print AppearanceDictionary: true Destination: 207 Annotation: Subtype: Link Rect: 258, 372, 265, 380 Flags: Print AppearanceDictionary: true Destination: 607 Annotation: Subtype: Link Rect: 267, 372, 274, 380 Flags: Print AppearanceDictionary: true Destination: 607 Annotation: Subtype: Link Rect: 112, 351, 119, 359 Flags: Print AppearanceDictionary: true Destination: 607 Annotation: Subtype: Link Rect: 190, 275, 194, 284 Flags: Print AppearanceDictionary: true Destination: 207 Annotation: Subtype: Link Rect: 157, 178, 162, 188 Flags: Print AppearanceDictionary: true Destination: 268 Annotation: Subtype: Link Rect: 277, 168, 281, 177 Flags: Print AppearanceDictionary: true Destination: 268 Annotation: Subtype: Link Rect: 173, 147, 177, 156 Flags: Print AppearanceDictionary: true Destination: 268 Annotation: Subtype: Link Rect: 195, 105, 199, 114 Flags: Print AppearanceDictionary: true Destination: 268 Annotation: Subtype: Link Rect: 278, 53, 282, 62 Flags: Print AppearanceDictionary: true Destination: 268 Annotation: Subtype: Link Rect: 388, 463, 393, 472 Flags: Print AppearanceDictionary: true Destination: 268 Annotation: Subtype: Link Rect: 396, 432, 400, 441 Flags: Print AppearanceDictionary: true Destination: 268 Annotation: Subtype: Link Rect: 487, 304, 491, 313 Flags: Print AppearanceDictionary: true Destination: 350 Annotation: Subtype: Link Rect: 540, 262, 545, 271 Flags: Print AppearanceDictionary: true Destination: 350 Annotation: Subtype: Link Rect: 351, 182, 359, 189 Flags: Print AppearanceDictionary: true Destination: 607 Annotation: Subtype: Link Rect: 414, 157, 419, 167 Flags: Print AppearanceDictionary: true Destination: 350 Annotation: Subtype: Link Rect: 462, 74, 466, 83 Flags: Print AppearanceDictionary: true Destination: 350 Annotation: Subtype: Link Rect: 325, 42, 330, 52 Flags: Print AppearanceDictionary: true Destination: 350 Annotation: Subtype: Link Rect: 436, 23, 551, 30 Flags: Print AppearanceDictionary: true Thumb: true Page: Label: 5 Annotations: Annotation: Subtype: Link Rect: 369, 23, 484, 30 Flags: Print AppearanceDictionary: true Annotation: Subtype: Link Rect: 547, 23, 551, 30 Flags: Print AppearanceDictionary: true Thumb: true Page: Label: 6 Annotations: Annotation: Subtype: Link Rect: 141, 87, 146, 96 Flags: Print AppearanceDictionary: true Destination: 350 Annotation: Subtype: Link Rect: 266, 56, 271, 65 Flags: Print AppearanceDictionary: true Destination: 350 Annotation: Subtype: Link Rect: 428, 76, 433, 86 Flags: Print AppearanceDictionary: true Destination: 350 Annotation: Subtype: Link Rect: 539, 45, 543, 55 Flags: Print AppearanceDictionary: true Destination: 350 Annotation: Subtype: Link Rect: 436, 23, 551, 30 Flags: Print AppearanceDictionary: true Thumb: true Page: Label: 7 Annotations: Annotation: Subtype: Link Rect: 225, 401, 233, 409 Flags: Print AppearanceDictionary: true Destination: 607 Annotation: Subtype: Link Rect: 266, 401, 273, 409 Flags: Print AppearanceDictionary: true Destination: 607 Annotation: Subtype: Link Rect: 76, 391, 83, 398 Flags: Print AppearanceDictionary: true Destination: 607 Annotation: Subtype: Link Rect: 80, 370, 87, 377 Flags: Print AppearanceDictionary: true Destination: 607 Annotation: Subtype: Link Rect: 153, 272, 158, 282 Flags: Print AppearanceDictionary: true Destination: 436 Annotation: Subtype: Link Rect: 63, 252, 68, 261 Flags: Print AppearanceDictionary: true Destination: 436 Annotation: Subtype: Link Rect: 134, 199, 139, 209 Flags: Print AppearanceDictionary: true Destination: 436 Annotation: Subtype: Link Rect: 156, 108, 163, 116 Flags: Print AppearanceDictionary: true Destination: null Annotation: Subtype: Link Rect: 164, 108, 171, 116 Flags: Print AppearanceDictionary: true Destination: 607 Annotation: Subtype: Link Rect: 43, 63, 48, 73 Flags: Print AppearanceDictionary: true Destination: 436 Annotation: Subtype: Link Rect: 213, 46, 221, 53 Flags: Print AppearanceDictionary: true Destination: null Annotation: Subtype: Link Rect: 395, 399, 400, 408 Flags: Print AppearanceDictionary: true Destination: 436 Annotation: Subtype: Link Rect: 303, 346, 308, 356 Flags: Print AppearanceDictionary: true Destination: 436 Annotation: Subtype: Link Rect: 542, 329, 549, 336 Flags: Print AppearanceDictionary: true Destination: 607 Annotation: Subtype: Link Rect: 424, 263, 429, 272 Flags: Print AppearanceDictionary: true Destination: 436 Annotation: Subtype: Link Rect: 367, 235, 374, 242 Flags: Print AppearanceDictionary: true Destination: null Annotation: Subtype: Link Rect: 520, 211, 525, 220 Flags: Print AppearanceDictionary: true Destination: 436 Annotation: Subtype: Link Rect: 452, 169, 456, 178 Flags: Print AppearanceDictionary: true Destination: 436 Annotation: Subtype: Link Rect: 369, 23, 484, 30 Flags: Print AppearanceDictionary: true Annotation: Subtype: Link Rect: 547, 23, 551, 30 Flags: Print AppearanceDictionary: true Thumb: true Page: Label: 8 Annotations: Annotation: Subtype: Link Rect: 264, 55, 269, 65 Flags: Print AppearanceDictionary: true Destination: 350 Annotation: Subtype: Link Rect: 436, 23, 551, 30 Flags: Print AppearanceDictionary: true Thumb: true Page: Label: 9 Annotations: Annotation: Subtype: Link Rect: 139, 488, 143, 497 Flags: Print AppearanceDictionary: true Destination: 489 Annotation: Subtype: Link Rect: 280, 467, 285, 476 Flags: Print AppearanceDictionary: true Destination: 489 Annotation: Subtype: Link Rect: 156, 436, 160, 445 Flags: Print AppearanceDictionary: true Destination: 489 Annotation: Subtype: Link Rect: 120, 404, 125, 414 Flags: Print AppearanceDictionary: true Destination: 489 Annotation: Subtype: Link Rect: 203, 320, 208, 330 Flags: Print AppearanceDictionary: true Destination: 489 Annotation: Subtype: Link Rect: 153, 178, 158, 188 Flags: Print AppearanceDictionary: true Destination: 529 Annotation: Subtype: Link Rect: 377, 540, 382, 550 Flags: Print AppearanceDictionary: true Destination: 529 Annotation: Subtype: Link Rect: 522, 470, 529, 478 Flags: Print AppearanceDictionary: true Destination: null Annotation: Subtype: Link Rect: 489, 449, 496, 457 Flags: Print AppearanceDictionary: true Destination: null Annotation: Subtype: Link Rect: 423, 439, 430, 446 Flags: Print AppearanceDictionary: true Destination: null Annotation: Subtype: Link Rect: 432, 439, 439, 446 Flags: Print AppearanceDictionary: true Destination: null Annotation: Subtype: Link Rect: 320, 418, 327, 426 Flags: Print AppearanceDictionary: true Destination: null Annotation: Subtype: Link Rect: 490, 418, 497, 426 Flags: Print AppearanceDictionary: true Destination: null Annotation: Subtype: Link Rect: 322, 376, 329, 384 Flags: Print AppearanceDictionary: true Destination: null Annotation: Subtype: Link Rect: 331, 376, 338, 384 Flags: Print AppearanceDictionary: true Destination: null Annotation: Subtype: Link Rect: 476, 320, 481, 330 Flags: Print AppearanceDictionary: true Destination: 529 Annotation: Subtype: Link Rect: 474, 247, 478, 257 Flags: Print AppearanceDictionary: true Destination: 529 Annotation: Subtype: Link Rect: 408, 226, 412, 236 Flags: Print AppearanceDictionary: true Destination: 350 Annotation: Subtype: Link Rect: 403, 216, 407, 225 Flags: Print AppearanceDictionary: true Destination: 529 Annotation: Subtype: Link Rect: 446, 111, 451, 121 Flags: Print AppearanceDictionary: true Destination: 529 Annotation: Subtype: Link Rect: 369, 23, 484, 30 Flags: Print AppearanceDictionary: true Annotation: Subtype: Link Rect: 547, 23, 551, 30 Flags: Print AppearanceDictionary: true Thumb: true Page: Label: 10 Annotations: Annotation: Subtype: Link Rect: 182, 93, 189, 101 Flags: Print AppearanceDictionary: true Destination: null Annotation: Subtype: Link Rect: 388, 93, 395, 101 Flags: Print AppearanceDictionary: true Destination: null Annotation: Subtype: Link Rect: 399, 93, 406, 101 Flags: Print AppearanceDictionary: true Destination: null Annotation: Subtype: Link Rect: 371, 52, 378, 59 Flags: Print AppearanceDictionary: true Destination: null Annotation: Subtype: Link Rect: 436, 23, 551, 30 Flags: Print AppearanceDictionary: true Thumb: true Page: Label: 11 Annotations: Annotation: Subtype: Link Rect: 143, 448, 150, 455 Flags: Print AppearanceDictionary: true Destination: null Annotation: Subtype: Link Rect: 123, 364, 131, 372 Flags: Print AppearanceDictionary: true Destination: null Annotation: Subtype: Link Rect: 122, 239, 129, 246 Flags: Print AppearanceDictionary: true Destination: null Annotation: Subtype: Link Rect: 254, 207, 261, 215 Flags: Print AppearanceDictionary: true Destination: null Annotation: Subtype: Link Rect: 263, 207, 270, 215 Flags: Print AppearanceDictionary: true Destination: null Annotation: Subtype: Link Rect: 191, 131, 195, 140 Flags: Print AppearanceDictionary: true Destination: 207 Annotation: Subtype: Link Rect: 224, 131, 229, 140 Flags: Print AppearanceDictionary: true Destination: 350 Annotation: Subtype: Link Rect: 219, 103, 226, 110 Flags: Print AppearanceDictionary: true Destination: null Annotation: Subtype: Link Rect: 257, 47, 262, 56 Flags: Print AppearanceDictionary: true Destination: 207 Annotation: Subtype: Link Rect: 507, 427, 514, 435 Flags: Print AppearanceDictionary: true Destination: null Annotation: Subtype: Link Rect: 516, 427, 523, 435 Flags: Print AppearanceDictionary: true Destination: null Annotation: Subtype: Link Rect: 330, 396, 337, 403 Flags: Print AppearanceDictionary: true Destination: null Annotation: Subtype: Link Rect: 401, 364, 408, 372 Flags: Print AppearanceDictionary: true Destination: null Annotation: Subtype: Link Rect: 476, 291, 483, 298 Flags: Print AppearanceDictionary: true Destination: null Annotation: Subtype: Link Rect: 338, 260, 346, 267 Flags: Print AppearanceDictionary: true Destination: null Annotation: Subtype: Link Rect: 347, 260, 355, 267 Flags: Print AppearanceDictionary: true Destination: null Annotation: Subtype: Link Rect: 506, 235, 510, 245 Flags: Print AppearanceDictionary: true Destination: 268 Annotation: Subtype: Link Rect: 352, 186, 360, 194 Flags: Print AppearanceDictionary: true Destination: null Annotation: Subtype: Link Rect: 486, 176, 493, 183 Flags: Print AppearanceDictionary: true Destination: null Annotation: Subtype: Link Rect: 402, 155, 409, 163 Flags: Print AppearanceDictionary: true Destination: null Annotation: Subtype: Link Rect: 369, 23, 484, 30 Flags: Print AppearanceDictionary: true Annotation: Subtype: Link Rect: 543, 23, 551, 30 Flags: Print AppearanceDictionary: true Thumb: true Page: Label: 12 Annotations: Annotation: Subtype: Link Rect: 67, 79, 74, 86 Flags: Print AppearanceDictionary: true Destination: null Annotation: Subtype: Link Rect: 436, 23, 551, 30 Flags: Print AppearanceDictionary: true Thumb: true Page: Label: 13 Annotations: Annotation: Subtype: Link Rect: 369, 23, 484, 30 Flags: Print AppearanceDictionary: true Annotation: Subtype: Link Rect: 543, 23, 551, 30 Flags: Print AppearanceDictionary: true Thumb: true Page: Label: 14 Annotations: Annotation: Subtype: Link Rect: 436, 23, 551, 30 Flags: Print AppearanceDictionary: true Thumb: true Page: Label: 15 Annotations: Annotation: Subtype: Link Rect: 369, 23, 484, 30 Flags: Print AppearanceDictionary: true Annotation: Subtype: Link Rect: 543, 23, 551, 30 Flags: Print AppearanceDictionary: true Thumb: true Page: Label: 16 Annotations: Annotation: Subtype: Link Rect: 43, 460, 212, 468 Flags: Print AppearanceDictionary: true Annotation: Subtype: Link Rect: 131, 429, 287, 437 Flags: Print AppearanceDictionary: true Annotation: Subtype: Link Rect: 43, 421, 60, 428 Flags: Print AppearanceDictionary: true Annotation: Subtype: Link Rect: 119, 415, 125, 421 Flags: Print AppearanceDictionary: true Destination: null Annotation: Subtype: Link Rect: 282, 407, 288, 413 Flags: Print AppearanceDictionary: true Destination: null Annotation: Subtype: Link Rect: 170, 395, 279, 403 Flags: Print AppearanceDictionary: true Annotation: Subtype: Link Rect: 43, 387, 175, 394 Flags: Print AppearanceDictionary: true Annotation: Subtype: Link Rect: 248, 296, 254, 302 Flags: Print AppearanceDictionary: true Destination: null Annotation: Subtype: Link Rect: 43, 260, 128, 267 Flags: Print AppearanceDictionary: true Annotation: Subtype: Link Rect: 272, 252, 291, 259 Flags: Print AppearanceDictionary: true Annotation: Subtype: Link Rect: 43, 243, 92, 250 Flags: Print AppearanceDictionary: true Annotation: Subtype: Link Rect: 251, 220, 257, 226 Flags: Print AppearanceDictionary: true Destination: null Annotation: Subtype: Link Rect: 87, 201, 200, 208 Flags: Print AppearanceDictionary: true Annotation: Subtype: Link Rect: 203, 203, 208, 209 Flags: Print AppearanceDictionary: true Destination: null Annotation: Subtype: Link Rect: 210, 203, 215, 209 Flags: Print AppearanceDictionary: true Destination: null Annotation: Subtype: Link Rect: 270, 192, 291, 200 Flags: Print AppearanceDictionary: true Annotation: Subtype: Link Rect: 43, 184, 102, 191 Flags: Print AppearanceDictionary: true Annotation: Subtype: Link Rect: 153, 144, 251, 152 Flags: Print AppearanceDictionary: true Annotation: Subtype: Link Rect: 181, 139, 186, 145 Flags: Print AppearanceDictionary: true Destination: null Annotation: Subtype: Link Rect: 128, 102, 215, 109 Flags: Print AppearanceDictionary: true Annotation: Subtype: Link Rect: 107, 43, 187, 50 Flags: Print AppearanceDictionary: true Annotation: Subtype: Link Rect: 399, 133, 461, 140 Flags: Print AppearanceDictionary: true Annotation: Subtype: Link Rect: 436, 23, 551, 30 Flags: Print AppearanceDictionary: true Thumb: true Page: Label: 17 Annotations: Annotation: Subtype: Link Rect: 218, 498, 291, 505 Flags: Print AppearanceDictionary: true Annotation: Subtype: Link Rect: 43, 489, 127, 496 Flags: Print AppearanceDictionary: true Annotation: Subtype: Link Rect: 158, 463, 161, 470 Flags: Print AppearanceDictionary: true Destination: 155 Annotation: Subtype: Link Rect: 175, 463, 178, 470 Flags: Print AppearanceDictionary: true Destination: 207 Annotation: Subtype: Link Rect: 191, 463, 195, 470 Flags: Print AppearanceDictionary: true Destination: 268 Annotation: Subtype: Link Rect: 222, 463, 225, 470 Flags: Print AppearanceDictionary: true Destination: 350 Annotation: Subtype: Link Rect: 246, 463, 249, 470 Flags: Print AppearanceDictionary: true Destination: 436 Annotation: Subtype: Link Rect: 263, 463, 266, 470 Flags: Print AppearanceDictionary: true Destination: 489 Annotation: Subtype: Link Rect: 280, 463, 283, 470 Flags: Print AppearanceDictionary: true Destination: 529 Annotation: Subtype: Link Rect: 120, 445, 123, 452 Flags: Print AppearanceDictionary: true Destination: 155 Annotation: Subtype: Link Rect: 137, 445, 140, 452 Flags: Print AppearanceDictionary: true Destination: 207 Annotation: Subtype: Link Rect: 175, 445, 178, 452 Flags: Print AppearanceDictionary: true Destination: 268 Annotation: Subtype: Link Rect: 199, 445, 202, 452 Flags: Print AppearanceDictionary: true Destination: 350 Annotation: Subtype: Link Rect: 223, 445, 226, 452 Flags: Print AppearanceDictionary: true Destination: 436 Annotation: Subtype: Link Rect: 240, 445, 243, 452 Flags: Print AppearanceDictionary: true Destination: 489 Annotation: Subtype: Link Rect: 369, 23, 484, 30 Flags: Print AppearanceDictionary: true Annotation: Subtype: Link Rect: 543, 23, 551, 30 Flags: Print AppearanceDictionary: true Thumb: true Page: Label: 18 Annotations: Annotation: Subtype: Link Rect: 463, 418, 551, 425 Flags: Print AppearanceDictionary: true Annotation: Subtype: Link Rect: 303, 409, 338, 416 Flags: Print AppearanceDictionary: true Annotation: Subtype: Link Rect: 475, 366, 538, 372 Flags: Print AppearanceDictionary: true Annotation: Subtype: Link Rect: 303, 357, 371, 364 Flags: Print AppearanceDictionary: true Annotation: Subtype: Link Rect: 472, 186, 551, 193 Flags: Print AppearanceDictionary: true Annotation: Subtype: Link Rect: 303, 177, 346, 184 Flags: Print AppearanceDictionary: true Annotation: Subtype: Link Rect: 436, 23, 551, 30 Flags: Print AppearanceDictionary: true Thumb: true Checksum: f39e22a1 Type: CRC32 Checksum: 651f2a2ec223a67a3e7d3fac77d43034 Type: MD5 Checksum: 325bc04a0d595918cd4dbca474a926273b7c0ef3 Type: SHA-1