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edu.harvard.hul.ois.jhove.module.pdf.PdfSimpleObject@11758f2a Children: Item: Title: Results Destination: edu.harvard.hul.ois.jhove.module.pdf.PdfSimpleObject@e720b71 Children: Item: Title: Global methylation correlates with immune signatures Destination: edu.harvard.hul.ois.jhove.module.pdf.PdfSimpleObject@1b26f7b2 Item: Title: Repression of immune genes in late-replicating regions Destination: edu.harvard.hul.ois.jhove.module.pdf.PdfSimpleObject@491cc5c9 Item: Title: Repression of immune genes in partial methylation domains Destination: edu.harvard.hul.ois.jhove.module.pdf.PdfSimpleObject@74ad1f1f Item: Title: Global methylation predicts responses to immunotherapy Destination: edu.harvard.hul.ois.jhove.module.pdf.PdfSimpleObject@6a1aab78 Item: Title: Global demethylation rules out the effect of aneuploidy Destination: edu.harvard.hul.ois.jhove.module.pdf.PdfSimpleObject@462d5aee Item: Title: Discussion Destination: edu.harvard.hul.ois.jhove.module.pdf.PdfSimpleObject@69b0fd6f Item: Title: Methods Destination: edu.harvard.hul.ois.jhove.module.pdf.PdfSimpleObject@757942a1 Children: Item: Title: TCGA molecular and clinical data Destination: edu.harvard.hul.ois.jhove.module.pdf.PdfSimpleObject@4a87761d Item: Title: Estimating global methylation levels Destination: edu.harvard.hul.ois.jhove.module.pdf.PdfSimpleObject@66d1af89 Item: Title: Linear regression modelling Destination: edu.harvard.hul.ois.jhove.module.pdf.PdfSimpleObject@8646db9 Item: Title: Identification of genes with differential replication timing Destination: edu.harvard.hul.ois.jhove.module.pdf.PdfSimpleObject@37374a5e Item: Title: Analysis of genes with differential replication timing Destination: edu.harvard.hul.ois.jhove.module.pdf.PdfSimpleObject@4671e53b Item: Title: Clustering of PMD and analysis of focal hypermethylation in PMD Destination: edu.harvard.hul.ois.jhove.module.pdf.PdfSimpleObject@2db7a79b Item: Title: Analysis of proximity of immune genes to PMD boundaries Destination: edu.harvard.hul.ois.jhove.module.pdf.PdfSimpleObject@6950e31 Item: Title: Collection and identification of marker gene sets Destination: edu.harvard.hul.ois.jhove.module.pdf.PdfSimpleObject@b7dd107 Item: Title: Quantification of LINE-1 and ERV expression Destination: edu.harvard.hul.ois.jhove.module.pdf.PdfSimpleObject@42eca56e Item: Title: Clinical data of the SMC cohort Destination: edu.harvard.hul.ois.jhove.module.pdf.PdfSimpleObject@52f759d7 Item: Title: Whole-exome, transcriptome, and methylome data for the SMC cohort Destination: edu.harvard.hul.ois.jhove.module.pdf.PdfSimpleObject@7cbd213e Item: Title: Melanoma cohort data Destination: edu.harvard.hul.ois.jhove.module.pdf.PdfSimpleObject@192d3247 Item: Title: Multivariate survival analysis Destination: edu.harvard.hul.ois.jhove.module.pdf.PdfSimpleObject@3ecd23d9 Item: Title: Reporting summary Destination: edu.harvard.hul.ois.jhove.module.pdf.PdfSimpleObject@569cfc36 Item: Title: Data availability Destination: edu.harvard.hul.ois.jhove.module.pdf.PdfSimpleObject@43bd930a Item: Title: Code availability Destination: edu.harvard.hul.ois.jhove.module.pdf.PdfSimpleObject@33723e30 Item: Title: References Destination: edu.harvard.hul.ois.jhove.module.pdf.PdfSimpleObject@64f6106c Item: Title: Acknowledgements Destination: edu.harvard.hul.ois.jhove.module.pdf.PdfSimpleObject@553a3d88 Item: Title: Author contributions Destination: edu.harvard.hul.ois.jhove.module.pdf.PdfSimpleObject@7a30d1e6 Item: Title: Additional information Destination: edu.harvard.hul.ois.jhove.module.pdf.PdfSimpleObject@5891e32e Info: Title: DNA methylation loss promotes immune evasion of tumours with high mutation and copy number load Author: Hyunchul Jung Subject: Nature Communications, doi:10.1038/s41467-019-12159-9 Keywords: Creator: Springer Producer: iText® 5.3.5 ©2000-2012 1T3XT BVBA (AGPL-version) CreationDate: Thu Sep 12 12:09:44 CEST 2019 ModDate: Fri Sep 13 12:38:35 CEST 2019 ID: 0xfd6502c70257235e282d21c031d0010d, 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FontName: KBGMHG+AdvOTea1a7398+20 Flags: Nonsymbolic FontBBox: -93, -197, 843, 791 FontFile3: true Encoding: WinAnsiEncoding Font: BaseFont: KBGMBF+Helvetica FontSubset: true FirstChar: 32 LastChar: 215 FontDescriptor: FontName: KBGMBF+Helvetica Flags: Nonsymbolic FontBBox: -166, -225, 1000, 931 FontFile3: true Encoding: WinAnsiEncoding Font: BaseFont: KBGMBG+Helvetica-Bold FontSubset: true FirstChar: 97 LastChar: 105 FontDescriptor: FontName: KBGMBG+Helvetica-Bold Flags: Nonsymbolic, ForceBold FontBBox: -170, -228, 1003, 962 FontFile3: true Encoding: WinAnsiEncoding XMP: application/pdf doi:10.1038/s41467-019-12159-9 DNA methylation loss promotes immune evasion of tumours with high mutation and copy number load Hyunchul Jung Hong Sook Kim Jeong Yeon Kim Jong-Mu Sun Jin Seok Ahn Myung-Ju Ahn Keunchil Park Manel Esteller Se-Hoon Lee Jung Kyoon Choi Springer US Nature Communications, doi:10.1038/s41467-019-12159-9 10.1038/s41467-019-12159-9 http://dx.doi.org/10.1038/s41467-019-12159-9 journal Nature Communications © 2019, The Author(s) 2041-1723 10.1038/s41467-019-12159-9 springer.com springerlink.com 2010-04-23 True 10.1038/s41467-019-12159-9 springer.com springerlink.com Springer 2019-09-13T12:38:35+02:00 2019-09-12T15:09:44+05:30 2019-09-13T12:38:35+02:00 True iText® 5.3.5 ©2000-2012 1T3XT BVBA (AGPL-version) VoR uuid:6ebf7ee4-6a9e-4fe4-86f7-3ad6813b17ed uuid:99d11c01-79c3-4425-877f-d94f5126a3ce default 1 converted uuid:565964f9-7f8b-4e64-a6a1-b657cf292aac converted to PDF/A-2b pdfToolbox 2019-09-12T15:10:49+05:30 2 B Hyunchul Jung http://orcid.org/0000-0003-0450-2190 http://ns.adobe.com/pdf/1.3/ pdf Adobe PDF Schema internal A name object indicating whether the document has been modified to include trapping information Trapped Text http://ns.adobe.com/pdfx/1.3/ pdfx pdfx internal ID of PDF/X standard GTS_PDFXVersion Text internal Conformance level of PDF/X standard GTS_PDFXConformance Text internal Company creating the PDF Company Text internal Date when document was last modified SourceModified Text external Mirrors crossmark:CrosMarkDomains CrossMarkDomains Seq Text internal Mirrors crossmark:DOI doi Text http://ns.adobe.com/xap/1.0/mm/ xmpMM XMP Media Management Schema internal UUID based identifier for specific incarnation of a document InstanceID URI internal The common identifier for all versions and renditions of a document. 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In lieu of using #other please reach out to the PRISM group at info@prismstandard.org to request addition of your term to the Aggregation Type Controlled Vocabulary. aggregationType Text external Copyright copyright Text external The Digital Object Identifier for the article. The DOI may also be used as the dc:identifier. If used as a dc:identifier, the URI form should be captured, and the bare identifier should also be captured using prism:doi. If an alternate unique identifier is used as the required dc:identifier, then the DOI should be specified as a bare identifier within prism:doi only. If the URL associated with a DOI is to be specified, then prism:url may be used in conjunction with prism:doi in order to provide the service endpoint (i.e. the URL). doi Text external ISSN for an electronic version of the issue in which the resource occurs. 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