04d52254a85d7951de62d350eebb859c 253285.pdf 7394503dfc32ad4dbbf62f5e8691bf22686a639a 253285.pdf 0580c44deb06f8c090cbde53fb556e0ebc8d802bcd1b1b9d026c98079c897a84 253285.pdf Title: Late-onset thymidine kinase 2 deficiency: a review of 18 cases Subject: Orphanet Journal of Rare Diseases, 2019, doi:10.1186/s13023-019-1071-z Keywords: TK2 deficiency,Mitochondrial myopathy,Multiple deletions Author: Cristina Domínguez-González Creator: Arbortext Advanced Print Publisher 9.1.440/W Unicode Producer: Acrobat Distiller 10.1.5 (Windows); modified using iText® 5.3.5 ©2000-2012 1T3XT BVBA (AGPL-version) CreationDate: Fri May 3 05:33:04 2019 CEST ModDate: Mon May 6 11:54:23 2019 CEST Tagged: no UserProperties: no Suspects: no Form: none JavaScript: no Pages: 10 Encrypted: no Page size: 595.276 x 790.866 pts Page rot: 0 File size: 2220563 bytes Optimized: no PDF version: 1.4 name type encoding emb sub uni object ID ------------------------------------ ----------------- ---------------- --- --- --- --------- MyriadPro-Regular Type 1 Custom yes no no 8 0 BODHNO+PyhqtrAdvTT99c4c969 Type 1C WinAnsi yes yes no 11 0 BODHMN+YpytmvAdvTTe45e47d2 Type 1C WinAnsi yes yes no 14 0 BODHNP+BlwsqlAdvTTb5929f4c+20 Type 1C WinAnsi yes yes no 55 0 BODHMO+KmxrwjAdvTTb5929f4c Type 1C WinAnsi yes yes no 54 0 BODHPA+NyknmhAdvTT86d47313 Type 1C WinAnsi yes yes no 15 0 BODHPB+QkpgywAdvTT86d47313+20 Type 1C WinAnsi yes yes no 12 0 BODGAH+CvsbnvAdvTTaf7f9f4f.B Type 1C WinAnsi yes yes no 9 0 BODIAC+YjcsgtAdvTT8861b38f.I Type 1C WinAnsi yes yes no 10 0 BODIPN+ClfqwvAdvTT7329fd89.I Type 1C WinAnsi yes yes no 16 0 BODJDN+TbmwwyAdvTT86d47313+22 Type 1C Custom yes yes no 13 0 BODJHN+PtfnmyAdvTTb5929f4c+22 Type 1C Custom yes yes no 53 0 BODJHO+VwxwcsAdvTTe45e47d2+22 Type 1C Custom yes yes no 56 0 BODJHP+TjvdrpAdvTTe45e47d2+20 Type 1C WinAnsi yes yes no 57 0 BOFDDC+DhcxtvAdvTTb5929f4c+03 Type 1C Custom yes yes yes 123 0 BOFDFC+PbnntqAdvTT99c4c969+20 Type 1C WinAnsi yes yes no 147 0 BOFDHC+XqtvmgAdvTTaf7f9f4f.B+20 Type 1C WinAnsi yes yes no 168 0 Jhove (Rel. 1.22.1, 2019-04-17) Date: 2022-05-07 02:31:02 CEST RepresentationInformation: 253285.pdf ReportingModule: PDF-hul, Rel. 1.12.1 (2019-04-17) LastModified: 2022-05-06 10:06:04 CEST Size: 2220563 Format: PDF Version: 1.4 Status: Well-Formed, but not valid SignatureMatches: PDF-hul ID: PDF-HUL-122 ErrorMessage: edu.harvard.hul.ois.jhove.module.pdf.PdfInvalidException: Invalid indirect destination - referenced object 'link_CR1' cannot be found Offset: 1963549 ID: PDF-HUL-122 ErrorMessage: edu.harvard.hul.ois.jhove.module.pdf.PdfInvalidException: Invalid indirect destination - referenced object 'link_CR3' cannot be found Offset: 1963549 ID: PDF-HUL-122 ErrorMessage: edu.harvard.hul.ois.jhove.module.pdf.PdfInvalidException: Invalid indirect destination - referenced object 'link_CR4' cannot be found Offset: 1963549 ID: PDF-HUL-122 ErrorMessage: edu.harvard.hul.ois.jhove.module.pdf.PdfInvalidException: Invalid indirect destination - referenced object 'link_CR5' cannot be found Offset: 1963549 ID: PDF-HUL-122 ErrorMessage: edu.harvard.hul.ois.jhove.module.pdf.PdfInvalidException: Invalid indirect destination - referenced object 'link_CR1' cannot be found Offset: 1963549 ID: PDF-HUL-122 ErrorMessage: edu.harvard.hul.ois.jhove.module.pdf.PdfInvalidException: Invalid indirect destination - referenced object 'link_CR6' cannot be found Offset: 1963549 ID: PDF-HUL-122 ErrorMessage: edu.harvard.hul.ois.jhove.module.pdf.PdfInvalidException: Invalid indirect destination - referenced object 'link_CR6' cannot be found Offset: 1963549 ID: PDF-HUL-122 ErrorMessage: edu.harvard.hul.ois.jhove.module.pdf.PdfInvalidException: Invalid indirect destination - referenced object 'link_CR7' cannot be found Offset: 1963549 ID: PDF-HUL-122 ErrorMessage: edu.harvard.hul.ois.jhove.module.pdf.PdfInvalidException: Invalid indirect destination - referenced object 'link_CR8' cannot be found Offset: 1963549 ID: PDF-HUL-122 ErrorMessage: edu.harvard.hul.ois.jhove.module.pdf.PdfInvalidException: Invalid indirect destination - referenced object 'link_CR9' cannot be found Offset: 1963549 ID: PDF-HUL-122 ErrorMessage: edu.harvard.hul.ois.jhove.module.pdf.PdfInvalidException: Invalid indirect destination - referenced object 'link_CR7' cannot be found Offset: 1963549 ID: PDF-HUL-122 ErrorMessage: edu.harvard.hul.ois.jhove.module.pdf.PdfInvalidException: Invalid indirect destination - referenced object 'link_CR8' cannot be found Offset: 1963549 ID: PDF-HUL-122 ErrorMessage: edu.harvard.hul.ois.jhove.module.pdf.PdfInvalidException: Invalid indirect destination - referenced object 'link_CR7' cannot be found Offset: 1963549 ID: PDF-HUL-122 ErrorMessage: edu.harvard.hul.ois.jhove.module.pdf.PdfInvalidException: Invalid indirect destination - referenced object 'link_CR10' cannot be found Offset: 1963549 ID: PDF-HUL-122 ErrorMessage: edu.harvard.hul.ois.jhove.module.pdf.PdfInvalidException: Invalid indirect destination - referenced object 'link_CR11' cannot be found Offset: 1963549 ID: PDF-HUL-122 ErrorMessage: edu.harvard.hul.ois.jhove.module.pdf.PdfInvalidException: Invalid indirect destination - referenced object 'link_CR12' cannot be found Offset: 1963549 ID: PDF-HUL-122 ErrorMessage: edu.harvard.hul.ois.jhove.module.pdf.PdfInvalidException: Invalid indirect destination - referenced object 'link_CR13' cannot be found Offset: 1963549 ID: PDF-HUL-122 ErrorMessage: edu.harvard.hul.ois.jhove.module.pdf.PdfInvalidException: Invalid indirect destination - referenced object 'link_CR10' cannot be found Offset: 1963549 ID: PDF-HUL-122 ErrorMessage: edu.harvard.hul.ois.jhove.module.pdf.PdfInvalidException: Invalid indirect destination - referenced object 'link_CR14' cannot be found Offset: 1963549 ID: PDF-HUL-122 ErrorMessage: edu.harvard.hul.ois.jhove.module.pdf.PdfInvalidException: Invalid indirect destination - referenced object 'link_CR15' cannot be found Offset: 1963549 ID: PDF-HUL-122 ErrorMessage: edu.harvard.hul.ois.jhove.module.pdf.PdfInvalidException: Invalid indirect destination - referenced object 'link_CR16' cannot be found Offset: 1963549 ID: PDF-HUL-122 ErrorMessage: edu.harvard.hul.ois.jhove.module.pdf.PdfInvalidException: Invalid indirect destination - referenced object 'link_CR17' cannot be found Offset: 1963549 ID: PDF-HUL-122 ErrorMessage: edu.harvard.hul.ois.jhove.module.pdf.PdfInvalidException: Invalid indirect destination - referenced object 'link_CR16' cannot be found Offset: 1963549 ID: PDF-HUL-122 ErrorMessage: edu.harvard.hul.ois.jhove.module.pdf.PdfInvalidException: Invalid indirect destination - referenced object 'link_Fig1' cannot be found Offset: 1963549 ID: PDF-HUL-122 ErrorMessage: edu.harvard.hul.ois.jhove.module.pdf.PdfInvalidException: Invalid indirect destination - referenced object 'link_CR18' cannot be found Offset: 1963549 ID: PDF-HUL-122 ErrorMessage: edu.harvard.hul.ois.jhove.module.pdf.PdfInvalidException: Invalid indirect destination - referenced object 'link_CR19' cannot be found Offset: 1963549 ID: PDF-HUL-122 ErrorMessage: edu.harvard.hul.ois.jhove.module.pdf.PdfInvalidException: Invalid indirect destination - referenced object 'link_CR20' cannot be found Offset: 1963549 ID: PDF-HUL-122 ErrorMessage: edu.harvard.hul.ois.jhove.module.pdf.PdfInvalidException: Invalid indirect destination - referenced object 'link_Fig2' cannot be found Offset: 1963549 ID: PDF-HUL-122 ErrorMessage: edu.harvard.hul.ois.jhove.module.pdf.PdfInvalidException: Invalid indirect destination - referenced object 'link_CR21' cannot be found Offset: 1963549 ID: PDF-HUL-122 ErrorMessage: edu.harvard.hul.ois.jhove.module.pdf.PdfInvalidException: Invalid indirect destination - referenced object 'link_CR7' cannot be found Offset: 1963549 ID: PDF-HUL-122 ErrorMessage: edu.harvard.hul.ois.jhove.module.pdf.PdfInvalidException: Invalid indirect destination - referenced object 'link_CR8' cannot be found Offset: 1963549 ID: PDF-HUL-122 ErrorMessage: edu.harvard.hul.ois.jhove.module.pdf.PdfInvalidException: Invalid indirect destination - referenced object 'link_CR7' cannot be found Offset: 1963549 ID: PDF-HUL-122 ErrorMessage: edu.harvard.hul.ois.jhove.module.pdf.PdfInvalidException: Invalid indirect destination - referenced object 'link_CR10' cannot be found Offset: 1963549 ID: PDF-HUL-122 ErrorMessage: edu.harvard.hul.ois.jhove.module.pdf.PdfInvalidException: Invalid indirect destination - referenced object 'link_CR7' cannot be found Offset: 1963549 ID: PDF-HUL-122 ErrorMessage: edu.harvard.hul.ois.jhove.module.pdf.PdfInvalidException: Invalid indirect destination - referenced object 'link_CR10' cannot be found Offset: 1963549 ID: PDF-HUL-122 ErrorMessage: edu.harvard.hul.ois.jhove.module.pdf.PdfInvalidException: Invalid indirect destination - referenced object 'link_CR22' cannot be found Offset: 1963549 ID: PDF-HUL-122 ErrorMessage: edu.harvard.hul.ois.jhove.module.pdf.PdfInvalidException: Invalid indirect destination - referenced object 'link_CR9' cannot be found Offset: 1963549 ID: PDF-HUL-122 ErrorMessage: edu.harvard.hul.ois.jhove.module.pdf.PdfInvalidException: Invalid indirect destination - referenced object 'link_CR7' cannot be found Offset: 1963549 ID: PDF-HUL-122 ErrorMessage: edu.harvard.hul.ois.jhove.module.pdf.PdfInvalidException: Invalid indirect destination - referenced object 'link_CR8' cannot be found Offset: 1963549 ID: PDF-HUL-122 ErrorMessage: edu.harvard.hul.ois.jhove.module.pdf.PdfInvalidException: Invalid indirect destination - referenced object 'link_CR22' cannot be found Offset: 1963549 ID: PDF-HUL-122 ErrorMessage: edu.harvard.hul.ois.jhove.module.pdf.PdfInvalidException: Invalid indirect destination - referenced object 'link_CR7' cannot be found Offset: 1963549 ID: PDF-HUL-122 ErrorMessage: edu.harvard.hul.ois.jhove.module.pdf.PdfInvalidException: Invalid indirect destination - referenced object 'link_CR23' cannot be found Offset: 1963549 ID: PDF-HUL-122 ErrorMessage: edu.harvard.hul.ois.jhove.module.pdf.PdfInvalidException: Invalid indirect destination - referenced object 'link_CR24' cannot be found Offset: 1963549 ID: PDF-HUL-122 ErrorMessage: edu.harvard.hul.ois.jhove.module.pdf.PdfInvalidException: Invalid indirect destination - referenced object 'link_CR12' cannot be found Offset: 1963549 ID: PDF-HUL-122 ErrorMessage: edu.harvard.hul.ois.jhove.module.pdf.PdfInvalidException: Invalid indirect destination - referenced object 'link_CR25' cannot be found Offset: 1963549 ID: PDF-HUL-122 ErrorMessage: edu.harvard.hul.ois.jhove.module.pdf.PdfInvalidException: Invalid indirect destination - referenced object 'link_CR27' cannot be found Offset: 1963549 ID: PDF-HUL-122 ErrorMessage: edu.harvard.hul.ois.jhove.module.pdf.PdfInvalidException: Invalid indirect destination - referenced object 'link_CR16' cannot be found Offset: 1963549 ID: PDF-HUL-122 ErrorMessage: edu.harvard.hul.ois.jhove.module.pdf.PdfInvalidException: Invalid indirect destination - referenced object 'link_CR17' cannot be found Offset: 1963549 ID: PDF-HUL-122 ErrorMessage: edu.harvard.hul.ois.jhove.module.pdf.PdfInvalidException: Invalid indirect destination - referenced object 'link_CR19' cannot be found Offset: 1963549 ID: PDF-HUL-122 ErrorMessage: edu.harvard.hul.ois.jhove.module.pdf.PdfInvalidException: Invalid indirect destination - referenced object 'link_CR8' cannot be found Offset: 1963549 ID: PDF-HUL-122 ErrorMessage: edu.harvard.hul.ois.jhove.module.pdf.PdfInvalidException: Invalid indirect destination - referenced object 'link_CR28' cannot be found Offset: 1963549 ID: PDF-HUL-122 ErrorMessage: edu.harvard.hul.ois.jhove.module.pdf.PdfInvalidException: Invalid indirect destination - referenced object 'link_CR10' cannot be found Offset: 1963549 ID: PDF-HUL-122 ErrorMessage: edu.harvard.hul.ois.jhove.module.pdf.PdfInvalidException: Invalid indirect destination - referenced object 'link_CR6' cannot be found Offset: 1963549 ID: PDF-HUL-122 ErrorMessage: edu.harvard.hul.ois.jhove.module.pdf.PdfInvalidException: Invalid indirect destination - referenced object 'link_CR7' cannot be found Offset: 1963549 ID: PDF-HUL-122 ErrorMessage: edu.harvard.hul.ois.jhove.module.pdf.PdfInvalidException: Invalid indirect destination - referenced object 'link_CR4' cannot be found Offset: 1963549 ID: PDF-HUL-122 ErrorMessage: edu.harvard.hul.ois.jhove.module.pdf.PdfInvalidException: Invalid indirect destination - referenced object 'link_CR29' cannot be found Offset: 1963549 ID: PDF-HUL-122 ErrorMessage: edu.harvard.hul.ois.jhove.module.pdf.PdfInvalidException: Invalid indirect destination - referenced object 'link_CR4' cannot be found Offset: 1963549 MIMEtype: application/pdf PDFMetadata: Objects: 400 FreeObjects: 1 IncrementalUpdates: 0 DocumentCatalog: PageLayout: SinglePage PageMode: UseOutlines Language: EN Outlines: Item: Title: Abstract Destination: edu.harvard.hul.ois.jhove.module.pdf.PdfSimpleObject@87f383f Children: Item: Title: Background Destination: edu.harvard.hul.ois.jhove.module.pdf.PdfSimpleObject@4eb7f003 Item: Title: Methods Destination: edu.harvard.hul.ois.jhove.module.pdf.PdfSimpleObject@eafc191 Item: Title: Results Destination: edu.harvard.hul.ois.jhove.module.pdf.PdfSimpleObject@612fc6eb Item: Title: Conclusions Destination: edu.harvard.hul.ois.jhove.module.pdf.PdfSimpleObject@1060b431 Item: Title: Background Destination: edu.harvard.hul.ois.jhove.module.pdf.PdfSimpleObject@612679d6 Item: Title: Methods Destination: edu.harvard.hul.ois.jhove.module.pdf.PdfSimpleObject@11758f2a Children: Item: Title: Patients Destination: edu.harvard.hul.ois.jhove.module.pdf.PdfSimpleObject@e720b71 Item: Title: Clinical evaluation Destination: edu.harvard.hul.ois.jhove.module.pdf.PdfSimpleObject@1b26f7b2 Item: Title: Respiratory assessment Destination: edu.harvard.hul.ois.jhove.module.pdf.PdfSimpleObject@491cc5c9 Item: Title: Laboratory tests Destination: edu.harvard.hul.ois.jhove.module.pdf.PdfSimpleObject@74ad1f1f Item: Title: Muscle MRI Destination: edu.harvard.hul.ois.jhove.module.pdf.PdfSimpleObject@6a1aab78 Item: Title: Aerobic exercise testing Destination: edu.harvard.hul.ois.jhove.module.pdf.PdfSimpleObject@462d5aee Item: Title: Muscle biopsy Destination: edu.harvard.hul.ois.jhove.module.pdf.PdfSimpleObject@69b0fd6f Item: Title: Genetic studies Destination: edu.harvard.hul.ois.jhove.module.pdf.PdfSimpleObject@757942a1 Item: Title: Results Destination: edu.harvard.hul.ois.jhove.module.pdf.PdfSimpleObject@4a87761d Children: Item: Title: Clinical manifestations (Table 1) Destination: edu.harvard.hul.ois.jhove.module.pdf.PdfSimpleObject@66d1af89 Item: Title: Respiratory function Destination: edu.harvard.hul.ois.jhove.module.pdf.PdfSimpleObject@8646db9 Item: Title: CK and lactate levels (Table 2) Destination: edu.harvard.hul.ois.jhove.module.pdf.PdfSimpleObject@37374a5e Item: Title: GDF-15 levels Destination: edu.harvard.hul.ois.jhove.module.pdf.PdfSimpleObject@4671e53b Item: Title: Muscle MRI findings Destination: edu.harvard.hul.ois.jhove.module.pdf.PdfSimpleObject@2db7a79b Item: Title: Aerobic exercise testing Destination: edu.harvard.hul.ois.jhove.module.pdf.PdfSimpleObject@6950e31 Item: Title: Muscle biopsies Destination: edu.harvard.hul.ois.jhove.module.pdf.PdfSimpleObject@b7dd107 Item: Title: Genetic studies Destination: edu.harvard.hul.ois.jhove.module.pdf.PdfSimpleObject@42eca56e Item: Title: Discussion Destination: edu.harvard.hul.ois.jhove.module.pdf.PdfSimpleObject@52f759d7 Item: Title: Conclusion Destination: edu.harvard.hul.ois.jhove.module.pdf.PdfSimpleObject@7cbd213e Item: Title: Abbreviations Destination: edu.harvard.hul.ois.jhove.module.pdf.PdfSimpleObject@192d3247 Item: Title: Acknowledgements Destination: edu.harvard.hul.ois.jhove.module.pdf.PdfSimpleObject@3ecd23d9 Item: Title: Funding Destination: edu.harvard.hul.ois.jhove.module.pdf.PdfSimpleObject@569cfc36 Item: Title: Availability of data and materials Destination: edu.harvard.hul.ois.jhove.module.pdf.PdfSimpleObject@43bd930a Item: Title: Authors’ contributions Destination: edu.harvard.hul.ois.jhove.module.pdf.PdfSimpleObject@33723e30 Item: Title: Ethics approval and consent to participate Destination: edu.harvard.hul.ois.jhove.module.pdf.PdfSimpleObject@64f6106c Item: Title: Consent for publication Destination: edu.harvard.hul.ois.jhove.module.pdf.PdfSimpleObject@553a3d88 Item: Title: Competing interests Destination: edu.harvard.hul.ois.jhove.module.pdf.PdfSimpleObject@7a30d1e6 Item: Title: Publisher’s Note Destination: edu.harvard.hul.ois.jhove.module.pdf.PdfSimpleObject@5891e32e Item: Title: Author details Destination: edu.harvard.hul.ois.jhove.module.pdf.PdfSimpleObject@cb0ed20 Item: Title: References Destination: edu.harvard.hul.ois.jhove.module.pdf.PdfSimpleObject@8e24743 Info: Title: Late-onset thymidine kinase 2 deficiency: a review of 18 cases Author: Cristina Domínguez-González Subject: Orphanet Journal of Rare Diseases, 2019, doi:10.1186/s13023-019-1071-z Keywords: TK2 deficiency,Mitochondrial myopathy,Multiple deletions Creator: Arbortext Advanced Print Publisher 9.1.440/W Unicode Producer: Acrobat Distiller 10.1.5 (Windows); modified using iText® 5.3.5 ©2000-2012 1T3XT BVBA (AGPL-version) CreationDate: Fri May 03 05:33:04 CEST 2019 ModDate: Mon May 06 11:54:23 CEST 2019 ID: 0x24eac063c3a51206827cb97001fc867a, 0xf2e9a1babac844d4b7b2e9dfc8a4826e Filters: FilterPipeline: FlateDecode FilterPipeline: DCTDecode Images: Image: NisoImageMetadata: FormatName: image/png ImageWidth: 54 ImageHeight: 103 BitsPerSample: 8 BitsPerSampleUnit: integer Filter: FlateDecode Image: NisoImageMetadata: FormatName: image/jpg CompressionScheme: JPEG ImageWidth: 176 ImageHeight: 182 BitsPerSample: 8 BitsPerSampleUnit: integer Intent: Perceptual Image: NisoImageMetadata: FormatName: image/png ImageWidth: 688 ImageHeight: 126 BitsPerSample: 8 BitsPerSampleUnit: integer Filter: FlateDecode Image: NisoImageMetadata: FormatName: image/png ImageWidth: 1949 ImageHeight: 1949 BitsPerSample: 8 BitsPerSampleUnit: integer Filter: FlateDecode Intent: Perceptual Image: NisoImageMetadata: FormatName: image/jpg CompressionScheme: JPEG ImageWidth: 1420 ImageHeight: 1036 BitsPerSample: 8 BitsPerSampleUnit: integer Intent: Perceptual Image: NisoImageMetadata: FormatName: image/png ImageWidth: 1100 ImageHeight: 90 ColorSpace: black is zero BitsPerSample: 1 BitsPerSampleUnit: integer Filter: FlateDecode Fonts: Type1: Font: BaseFont: MyriadPro-Regular FirstChar: 1 LastChar: 255 FontDescriptor: FontName: MyriadPro-Regular Flags: Nonsymbolic FontBBox: -46, -250, 1126, 879 FontFile: true EncodingDictionary: BaseEncoding: WinAnsiEncoding Differences: true Font: BaseFont: BOFDHC+XqtvmgAdvTTaf7f9f4f.B+20 FontSubset: true FirstChar: 32 LastChar: 146 FontDescriptor: FontName: BOFDHC+XqtvmgAdvTTaf7f9f4f.B+20 Flags: Nonsymbolic FontBBox: -468, -197, 1656, 864 FontFile3: true Encoding: WinAnsiEncoding Font: BaseFont: BODGAH+CvsbnvAdvTTaf7f9f4f.B FontSubset: true FirstChar: 32 LastChar: 117 FontDescriptor: FontName: BODGAH+CvsbnvAdvTTaf7f9f4f.B Flags: Nonsymbolic FontBBox: -218, -250, 875, 895 FontFile3: true Encoding: WinAnsiEncoding Font: BaseFont: BODIAC+YjcsgtAdvTT8861b38f.I FontSubset: true FirstChar: 32 LastChar: 84 FontDescriptor: FontName: BODIAC+YjcsgtAdvTT8861b38f.I Flags: Nonsymbolic FontBBox: -187, -239, 1062, 875 FontFile3: true Encoding: WinAnsiEncoding Font: BaseFont: BODHNO+PyhqtrAdvTT99c4c969 FontSubset: true FirstChar: 32 LastChar: 121 FontDescriptor: FontName: BODHNO+PyhqtrAdvTT99c4c969 Flags: Nonsymbolic FontBBox: -41, -250, 854, 885 FontFile3: true Encoding: WinAnsiEncoding Font: BaseFont: BODHPB+QkpgywAdvTT86d47313+20 FontSubset: true FirstChar: 32 LastChar: 150 FontDescriptor: FontName: BODHPB+QkpgywAdvTT86d47313+20 Flags: Nonsymbolic FontBBox: -218, -218, 1291, 812 FontFile3: true Encoding: WinAnsiEncoding Font: BaseFont: BODJDN+TbmwwyAdvTT86d47313+22 FontSubset: true FirstChar: 21 LastChar: 22 FontDescriptor: FontName: BODJDN+TbmwwyAdvTT86d47313+22 Flags: Nonsymbolic FontBBox: -166, -260, 1031, 906 FontFile3: true EncodingDictionary: BaseEncoding: WinAnsiEncoding Differences: true Font: BaseFont: BODHMN+YpytmvAdvTTe45e47d2 FontSubset: true FirstChar: 32 LastChar: 237 FontDescriptor: FontName: BODHMN+YpytmvAdvTTe45e47d2 Flags: Nonsymbolic FontBBox: -218, -250, 833, 875 FontFile3: true Encoding: WinAnsiEncoding Font: BaseFont: BODHPA+NyknmhAdvTT86d47313 FontSubset: true FirstChar: 32 LastChar: 183 FontDescriptor: FontName: BODHPA+NyknmhAdvTT86d47313 Flags: Serif, Nonsymbolic FontBBox: -218, -239, 1020, 875 FontFile3: true Encoding: WinAnsiEncoding Font: BaseFont: BODIPN+ClfqwvAdvTT7329fd89.I FontSubset: true FirstChar: 32 LastChar: 117 FontDescriptor: FontName: BODIPN+ClfqwvAdvTT7329fd89.I Flags: Nonsymbolic FontBBox: -218, -250, 885, 864 FontFile3: true Encoding: WinAnsiEncoding Font: BaseFont: BOFDFC+PbnntqAdvTT99c4c969+20 FontSubset: true FirstChar: 32 LastChar: 146 FontDescriptor: FontName: BOFDFC+PbnntqAdvTT99c4c969+20 Flags: Nonsymbolic FontBBox: -447, -197, 1583, 864 FontFile3: true Encoding: WinAnsiEncoding Font: BaseFont: BODJHN+PtfnmyAdvTTb5929f4c+22 FontSubset: true FirstChar: 21 LastChar: 22 FontDescriptor: FontName: BODJHN+PtfnmyAdvTTb5929f4c+22 Flags: Nonsymbolic FontBBox: -10, -218, 1083, 906 FontFile3: true EncodingDictionary: BaseEncoding: WinAnsiEncoding Differences: true Font: BaseFont: BODHMO+KmxrwjAdvTTb5929f4c FontSubset: true FirstChar: 32 LastChar: 250 FontDescriptor: FontName: BODHMO+KmxrwjAdvTTb5929f4c Flags: Nonsymbolic FontBBox: -41, -250, 812, 864 FontFile3: true Encoding: WinAnsiEncoding Font: BaseFont: BODHNP+BlwsqlAdvTTb5929f4c+20 FontSubset: true FirstChar: 32 LastChar: 150 FontDescriptor: FontName: BODHNP+BlwsqlAdvTTb5929f4c+20 Flags: Nonsymbolic FontBBox: -447, -208, 1375, 864 FontFile3: true Encoding: WinAnsiEncoding Font: BaseFont: BODJHO+VwxwcsAdvTTe45e47d2+22 FontSubset: true FirstChar: 21 LastChar: 22 FontDescriptor: FontName: BODJHO+VwxwcsAdvTTe45e47d2+22 Flags: Nonsymbolic FontBBox: -10, -229, 1020, 906 FontFile3: true EncodingDictionary: BaseEncoding: WinAnsiEncoding Differences: true Font: BaseFont: BODJHP+TjvdrpAdvTTe45e47d2+20 FontSubset: true FirstChar: 32 LastChar: 150 FontDescriptor: FontName: BODJHP+TjvdrpAdvTTe45e47d2+20 Flags: Nonsymbolic FontBBox: -447, -197, 1302, 864 FontFile3: true Encoding: WinAnsiEncoding Font: BaseFont: BOFDDC+DhcxtvAdvTTb5929f4c+03 FontSubset: true FirstChar: 1 LastChar: 2 FontDescriptor: FontName: BOFDDC+DhcxtvAdvTTb5929f4c+03 Flags: Symbolic FontBBox: -531, -260, 802, 968 FontFile3: true EncodingDictionary: Differences: true ToUnicode: true XMP: TK2 deficiency,Mitochondrial myopathy,Multiple deletions Acrobat Distiller 10.1.5 (Windows); modified using iText® 5.3.5 ©2000-2012 1T3XT BVBA (AGPL-version) application/pdf 10.1186/s13023-019-1071-z Orphanet Journal of Rare Diseases Orphanet Journal of Rare Diseases, 2019, doi:10.1186/s13023-019-1071-z TK2 deficiency Mitochondrial myopathy Multiple deletions Late-onset thymidine kinase 2 deficiency: a review of 18 cases Cristina Domínguez-González Aurelio Hernández-Laín Eloy Rivas Ana Hernández-Voth Javier Sayas Catalán Roberto Fernández-Torrón Carmen Fuiza-Luces Jorge García García Germán Morís Montse Olivé Frances Miralles Jordi Díaz-Manera Candela Caballero Bosco Méndez-Ferrer Ramon Martí Elena García Arumi María Carmen Badosa Jesús Esteban Cecilia Jimenez-Mallebrera Alberto Blazquez Encinar Joaquín Arenas Michio Hirano Miguel Ángel Martin Carmen Paradas 2019-05-06T11:54:23+02:00 2019-05-03T11:33:04+08:00 Arbortext Advanced Print Publisher 9.1.440/W Unicode 2019-05-06T11:54:23+02:00 uuid:d172329b-9c28-46c0-ade2-387f8c4457e4 uuid:7a13474a-d911-4ca9-acb6-d52e12eba03c default 1 converted uuid:53904de0-7b68-44fb-89e5-1dff698f3eaa converted to PDF/A-2b pdfToolbox 2019-05-03T11:46:08+08:00 2 B Springer Nature ORCID Schema http://springernature.com/ns/xmpExtensions/2.0/ sn authorInfo Bag AuthorInformation external Author information: contains the name of each author and his/her ORCID (ORCiD: Open Researcher and Contributor ID). An ORCID is a persistent identifier (a non-proprietary alphanumeric code) to uniquely identify scientific and other academic authors. editorInfo Bag EditorInformation external Editor information: contains the name of each editor and his/her ORCID identifier. seriesEditorInfo Bag SeriesEditorInformation external Series editor information: contains the name of each series editor and his/her ORCID identifier. AuthorInformation http://springernature.com/ns/xmpExtensions/2.0/authorInfo/ author Specifies the types of author information: name and ORCID of an author. name Text Gives the name of an author. orcid URI Gives the ORCID of an author. EditorInformation http://springernature.com/ns/xmpExtensions/2.0/editorInfo/ editor Specifies the types of editor information: name and ORCID of an editor. name Text Gives the name of an editor. orcid URI Gives the ORCID of an editor. SeriesEditorInformation http://springernature.com/ns/xmpExtensions/2.0/seriesEditorInfo/ seriesEditor Specifies the types of series editor information: name and ORCID of a series editor. name Text Gives the name of a series editor. orcid URI Gives the ORCID of a series editor. http://ns.adobe.com/pdf/1.3/ pdf Adobe PDF Schema internal A name object indicating whether the document has been modified to include trapping information Trapped Text http://ns.adobe.com/xap/1.0/mm/ xmpMM XMP Media Management Schema internal UUID based identifier for specific incarnation of a document InstanceID URI internal The common identifier for all versions and renditions of a document. OriginalDocumentID URI internal A reference to the original document from which this one is derived. It is a minimal reference; missing components can be assumed to be unchanged. For example, a new version might only need to specify the instance ID and version number of the previous version, or a rendition might only need to specify the instance ID and rendition class of the original. DerivedFrom ResourceRef Identifies a portion of a document. This can be a position at which the document has been changed since the most recent event history (stEvt:changed). For a resource within an xmpMM:Ingredients list, the ResourceRef uses this type to identify both the portion of the containing document that refers to the resource, and the portion of the referenced resource that is referenced. http://ns.adobe.com/xap/1.0/sType/Part# stPart Part http://ns.adobe.com/xap/1.0/t/pg/ xmpTPg XMP Paged-Text internal A structure containing the characteristics of a font used in a document Fonts Bag Font internal XMP08 Spec: An ordered array of plate names that are needed to print the document (including any in contained documents). PlateNames Seq Text A structure containing the characteristics of a font used in a document. http://ns.adobe.com/xap/1.0/sType/Font# stFnt Font http://ns.adobe.com/pdfx/1.3/ pdfx PDF/X ID Schema internal ID of PDF/X standard GTS_PDFXVersion Text internal Conformance level of PDF/X standard GTS_PDFXConformance Text internal Company creating the PDF Company Text internal Date when document was last modified SourceModified Text http://www.aiim.org/pdfa/ns/id/ pdfaid PDF/A ID Schema internal Part of PDF/A standard part Integer internal Amendment of PDF/A standard amd Text internal Conformance level of PDF/A standard conformance Text Pages: Page: Sequence: 1 Annotations: Annotation: Subtype: Link Rect: 496, 635, 538, 677 Flags: Print AppearanceDictionary: true Annotation: Subtype: Link Rect: 270, 175, 275, 185 Flags: Print AppearanceDictionary: true Destination: null Annotation: Subtype: Link Rect: 280, 175, 285, 185 Flags: Print AppearanceDictionary: true Destination: null Annotation: Subtype: Link Rect: 330, 175, 335, 185 Flags: Print AppearanceDictionary: true Destination: null Annotation: Subtype: Link Rect: 341, 175, 346, 185 Flags: Print AppearanceDictionary: true Destination: null Annotation: Subtype: Link Rect: 239, 65, 357, 72 Flags: Print AppearanceDictionary: true Annotation: Subtype: Link Rect: 182, 41, 321, 48 Flags: Print AppearanceDictionary: true Annotation: Subtype: Link Rect: 114, 144, 160, 152 Flags: Print AppearanceDictionary: true Thumb: true Page: Sequence: 2 Annotations: Annotation: Subtype: Link Rect: 79, 681, 84, 690 Flags: Print AppearanceDictionary: true Destination: null Annotation: Subtype: Link Rect: 88, 681, 93, 690 Flags: Print AppearanceDictionary: true Destination: null Annotation: Subtype: Link Rect: 112, 609, 116, 618 Flags: Print AppearanceDictionary: true Destination: null Annotation: Subtype: Link Rect: 134, 525, 139, 534 Flags: Print AppearanceDictionary: true Destination: null Annotation: Subtype: Link Rect: 144, 525, 148, 534 Flags: Print AppearanceDictionary: true Destination: null Annotation: Subtype: Link Rect: 159, 477, 164, 486 Flags: Print AppearanceDictionary: true Destination: null Annotation: Subtype: Link Rect: 172, 381, 177, 390 Flags: Print AppearanceDictionary: true Destination: null Annotation: Subtype: Link Rect: 111, 345, 116, 354 Flags: Print AppearanceDictionary: true Destination: null Annotation: Subtype: Link Rect: 135, 117, 139, 126 Flags: Print AppearanceDictionary: true Destination: null Annotation: Subtype: Link Rect: 200, 117, 210, 126 Flags: Print AppearanceDictionary: true Destination: null Annotation: Subtype: Link Rect: 341, 561, 351, 570 Flags: Print AppearanceDictionary: true Destination: null Annotation: Subtype: Link Rect: 336, 285, 346, 294 Flags: Print AppearanceDictionary: true Destination: null Thumb: true Page: Sequence: 3 Annotations: Annotation: Subtype: Link Rect: 97, 669, 106, 678 Flags: Print AppearanceDictionary: true Destination: null Annotation: Subtype: Link Rect: 157, 429, 167, 438 Flags: Print AppearanceDictionary: true Destination: null Annotation: Subtype: Link Rect: 172, 429, 182, 438 Flags: Print AppearanceDictionary: true Destination: null Annotation: Subtype: Link Rect: 176, 357, 181, 366 Flags: Print AppearanceDictionary: true Destination: 51 Thumb: true Page: Sequence: 4 Thumb: true Page: Sequence: 5 Annotations: Annotation: Subtype: Link Rect: 169, 657, 174, 666 Flags: Print AppearanceDictionary: true Destination: 65 Annotation: Subtype: Link Rect: 276, 525, 285, 534 Flags: Print AppearanceDictionary: true Destination: null Annotation: Subtype: Link Rect: 107, 501, 116, 510 Flags: Print AppearanceDictionary: true Destination: null Annotation: Subtype: Link Rect: 178, 489, 187, 498 Flags: Print AppearanceDictionary: true Destination: null Annotation: Subtype: Link Rect: 522, 669, 531, 678 Flags: Print AppearanceDictionary: true Destination: null Annotation: Subtype: Link Rect: 507, 489, 512, 498 Flags: Print AppearanceDictionary: true Destination: null Thumb: true Page: Sequence: 6 Thumb: true Page: Sequence: 7 Annotations: Annotation: Subtype: Link Rect: 154, 597, 164, 606 Flags: Print AppearanceDictionary: true Destination: null Annotation: Subtype: Link Rect: 237, 561, 247, 570 Flags: Print AppearanceDictionary: true Destination: null Annotation: Subtype: Link Rect: 207, 513, 217, 522 Flags: Print AppearanceDictionary: true Destination: null Annotation: Subtype: Link Rect: 191, 357, 196, 366 Flags: Print AppearanceDictionary: true Destination: null Annotation: Subtype: Link Rect: 59, 297, 69, 306 Flags: Print AppearanceDictionary: true Destination: null Annotation: Subtype: Link Rect: 238, 261, 243, 270 Flags: Print AppearanceDictionary: true Destination: 65 Annotation: Subtype: Link Rect: 217, 213, 222, 222 Flags: Print AppearanceDictionary: true Destination: 65 Annotation: Subtype: Link Rect: 147, 189, 152, 198 Flags: Print AppearanceDictionary: true Destination: null Annotation: Subtype: Link Rect: 159, 189, 164, 198 Flags: Print AppearanceDictionary: true Destination: null Annotation: Subtype: Link Rect: 181, 57, 186, 66 Flags: Print AppearanceDictionary: true Destination: null Annotation: Subtype: Link Rect: 196, 57, 206, 66 Flags: Print AppearanceDictionary: true Destination: null Annotation: Subtype: Link Rect: 355, 525, 360, 534 Flags: Print AppearanceDictionary: true Destination: null Annotation: Subtype: Link Rect: 366, 525, 376, 534 Flags: Print AppearanceDictionary: true Destination: null Annotation: Subtype: Link Rect: 385, 525, 395, 534 Flags: Print AppearanceDictionary: true Destination: null Annotation: Subtype: Link Rect: 510, 441, 515, 450 Flags: Print AppearanceDictionary: true Destination: null Annotation: Subtype: Link Rect: 349, 357, 354, 366 Flags: Print AppearanceDictionary: true Destination: null Annotation: Subtype: Link Rect: 359, 357, 364, 366 Flags: Print AppearanceDictionary: true Destination: null Annotation: Subtype: Link Rect: 369, 357, 379, 366 Flags: Print AppearanceDictionary: true Destination: null Thumb: true Page: Sequence: 8 Annotations: Annotation: Subtype: Link Rect: 280, 357, 285, 366 Flags: Print AppearanceDictionary: true Destination: 51 Annotation: Subtype: Link Rect: 185, 105, 189, 114 Flags: Print AppearanceDictionary: true Destination: null Annotation: Subtype: Link Rect: 307, 333, 317, 342 Flags: Print AppearanceDictionary: true Destination: null Annotation: Subtype: Link Rect: 404, 309, 414, 318 Flags: Print AppearanceDictionary: true Destination: null Annotation: Subtype: Link Rect: 389, 165, 398, 174 Flags: Print AppearanceDictionary: true Destination: null Annotation: Subtype: Link Rect: 404, 165, 414, 174 Flags: Print AppearanceDictionary: true Destination: null Annotation: Subtype: Link Rect: 419, 165, 429, 174 Flags: Print AppearanceDictionary: true Destination: null Annotation: Subtype: Link Rect: 425, 117, 435, 126 Flags: Print AppearanceDictionary: true Destination: null Annotation: Subtype: Link Rect: 443, 117, 453, 126 Flags: Print AppearanceDictionary: true Destination: null Annotation: Subtype: Link Rect: 489, 69, 499, 78 Flags: Print AppearanceDictionary: true Destination: null Thumb: true Page: Sequence: 9 Annotations: Annotation: Subtype: Link Rect: 85, 549, 90, 558 Flags: Print AppearanceDictionary: true Destination: null Annotation: Subtype: Link Rect: 100, 501, 110, 510 Flags: Print AppearanceDictionary: true Destination: null Annotation: Subtype: Link Rect: 181, 429, 191, 438 Flags: Print AppearanceDictionary: true Destination: null Annotation: Subtype: Link Rect: 244, 333, 249, 342 Flags: Print AppearanceDictionary: true Destination: null Annotation: Subtype: Link Rect: 254, 333, 259, 342 Flags: Print AppearanceDictionary: true Destination: null Annotation: Subtype: Link Rect: 80, 237, 85, 246 Flags: Print AppearanceDictionary: true Destination: null Annotation: Subtype: Link Rect: 508, 633, 518, 642 Flags: Print AppearanceDictionary: true Destination: null Annotation: Subtype: Link Rect: 461, 609, 466, 618 Flags: Print AppearanceDictionary: true Destination: null Thumb: true Page: Sequence: 10 Thumb: true Checksum: c198af5d Type: CRC32 Checksum: 04d52254a85d7951de62d350eebb859c Type: MD5 Checksum: 7394503dfc32ad4dbbf62f5e8691bf22686a639a Type: SHA-1