867b9d09c2ac35b34ed6eb49c80be61e serrano-falcon-et-al-2019-clinical-response.pdf a89a43f4c1734a69d71b4fed0a05014e09a90104 serrano-falcon-et-al-2019-clinical-response.pdf 7f2e15cbf26e5c4aef1d906d218e907cf469e8d8015bb0b613b31af3c7e4eb0d serrano-falcon-et-al-2019-clinical-response.pdf Title: Clinical response to linaclotide at week 4 predicts sustained response in irritable bowel syndrome with constipation and improvements in digestive and extra-digestive symptoms Subject: Therap Adv Gastroenterol 2019.12:1756284819857358 Keywords: abdominal pain,constipation,functional gastrointestinal diseases,irritable bowel syndrome Author: Blanca Serrano-Falcón, Sílvia Delgado-Aros, Fermín Mearin, Constanza Ciriza de los Ríos, Jordi Serra, Miguel Mínguez, Miguel Montoro Huguet, Antonia Perelló, Cecilio Santander, Ángeles Pérez Aisa, Inmaculada Bañón-Rodríguez, and Enrique Rey Creator: Adobe InDesign CS5.5 (7.5) Producer: Adobe PDF Library 9.9; modified using iText 4.2.0 by 1T3XT CreationDate: Mon Jun 24 13:24:17 2019 CEST ModDate: Thu Jul 27 18:39:26 2023 CEST Tagged: no UserProperties: no Suspects: no Form: none JavaScript: no Pages: 14 Encrypted: no Page size: 595.276 x 793.701 pts Page rot: 0 File size: 489538 bytes Optimized: no PDF version: 1.4 name type encoding emb sub uni object ID ------------------------------------ ----------------- ---------------- --- --- --- --------- UZCVPZ+DIN-Regular Type 1C Custom yes yes yes 29 0 QTEXLH+DIN-Bold Type 1C WinAnsi yes yes yes 30 0 RSODZF+DIN-RegularItalic Type 1C WinAnsi yes yes yes 31 0 MIBZHP+SymbolMT CID TrueType Identity-H yes yes yes 32 0 KFCNFT+TimesNewRomanPS-BoldMT Type 1C WinAnsi yes yes yes 33 0 OLALJL+DIN-BoldItalic Type 1C WinAnsi yes yes yes 34 0 JGNHRV+PlantinStd Type 1C Custom yes yes yes 35 0 GRTRBB+DIN-RegularItalic Type 1C WinAnsi yes yes yes 163 0 CBZMXJ+PlantinStd-Italic Type 1C Custom yes yes yes 44 0 HLMVPZ+MathematicalPiLTStd Type 1C Custom yes yes yes 45 0 ERBYZF+HelveticaLTStd-Roman Type 1C WinAnsi yes yes yes 74 0 Jhove (Rel. 1.22.1, 2019-04-17) Date: 2023-07-28 02:45:22 CEST RepresentationInformation: serrano-falcon-et-al-2019-clinical-response.pdf ReportingModule: PDF-hul, Rel. 1.12.1 (2019-04-17) LastModified: 2023-07-27 18:40:50 CEST Size: 489538 Format: PDF Version: 1.4 Status: Well-Formed and valid SignatureMatches: PDF-hul MIMEtype: application/pdf PDFMetadata: Objects: 0 FreeObjects: 2 IncrementalUpdates: 0 DocumentCatalog: ViewerPreferences: HideToolbar: false HideMenubar: false HideWindowUI: false FitWindow: false CenterWindow: false DisplayDocTitle: false NonFullScreenPageMode: UseNone Direction: L2R ViewArea: CropBox ViewClip: CropBox PrintArea: CropBox PageClip: CropBox PageLayout: SinglePage PageMode: UseNone Filters: FilterPipeline: FlateDecode Images: Image: NisoImageMetadata: FormatName: image/png ImageWidth: 228 ImageHeight: 45 ColorSpace: RGB BitsPerSample: 8 BitsPerSampleUnit: integer Filter: FlateDecode Image: NisoImageMetadata: FormatName: image/png ImageWidth: 200 ImageHeight: 70 ColorSpace: black is zero BitsPerSample: 8 BitsPerSampleUnit: integer Filter: FlateDecode Intent: RelativeColorimetric Name: X Image: NisoImageMetadata: FormatName: image/png ImageWidth: 228 ImageHeight: 45 ColorSpace: black is zero BitsPerSample: 8 BitsPerSampleUnit: integer Filter: FlateDecode Fonts: Type0: Font: BaseFont: MIBZHP+SymbolMT Encoding: Identity-H ToUnicode: true Type1: Font: BaseFont: KFCNFT+TimesNewRomanPS-BoldMT FontSubset: true FirstChar: 51 LastChar: 56 FontDescriptor: FontName: KFCNFT+TimesNewRomanPS-BoldMT Flags: Serif, Nonsymbolic FontBBox: -557, -216, 2000, 891 FontFile3: true Encoding: WinAnsiEncoding ToUnicode: true Font: BaseFont: OLALJL+DIN-BoldItalic FontSubset: true FirstChar: 58 LastChar: 117 FontDescriptor: FontName: OLALJL+DIN-BoldItalic Flags: Nonsymbolic FontBBox: -161, -203, 1107, 1006 FontFile3: true Encoding: WinAnsiEncoding ToUnicode: true Font: BaseFont: JGNHRV+PlantinStd FontSubset: true FirstChar: 31 LastChar: 243 FontDescriptor: FontName: JGNHRV+PlantinStd Flags: Serif, Nonsymbolic FontBBox: -132, -250, 1052, 908 FontFile3: true EncodingDictionary: BaseEncoding: WinAnsiEncoding Differences: true ToUnicode: true Font: BaseFont: ERBYZF+HelveticaLTStd-Roman FontSubset: true FirstChar: 32 LastChar: 117 FontDescriptor: FontName: ERBYZF+HelveticaLTStd-Roman Flags: Nonsymbolic FontBBox: -166, -225, 1000, 931 FontFile3: true Encoding: WinAnsiEncoding ToUnicode: true Font: BaseFont: CBZMXJ+PlantinStd-Italic FontSubset: true FirstChar: 31 LastChar: 243 FontDescriptor: FontName: CBZMXJ+PlantinStd-Italic Flags: Serif, Nonsymbolic, Italic FontBBox: -148, -250, 1123, 920 FontFile3: true EncodingDictionary: BaseEncoding: WinAnsiEncoding Differences: true ToUnicode: true Font: BaseFont: UZCVPZ+DIN-Regular FontSubset: true FirstChar: 31 LastChar: 243 FontDescriptor: FontName: UZCVPZ+DIN-Regular Flags: Nonsymbolic FontBBox: -104, -226, 1115, 985 FontFile3: true EncodingDictionary: BaseEncoding: WinAnsiEncoding Differences: true ToUnicode: true Font: BaseFont: HLMVPZ+MathematicalPiLTStd FontSubset: true FirstChar: 27 LastChar: 31 FontDescriptor: FontName: HLMVPZ+MathematicalPiLTStd Flags: Symbolic FontBBox: -30, -292, 1023, 981 FontFile3: true EncodingDictionary: BaseEncoding: WinAnsiEncoding Differences: true ToUnicode: true Font: BaseFont: QTEXLH+DIN-Bold FontSubset: true FirstChar: 32 LastChar: 243 FontDescriptor: FontName: QTEXLH+DIN-Bold Flags: Nonsymbolic FontBBox: -115, -206, 1158, 1015 FontFile3: true Encoding: WinAnsiEncoding ToUnicode: true Font: BaseFont: RSODZF+DIN-RegularItalic FontSubset: true FirstChar: 32 LastChar: 121 FontDescriptor: FontName: RSODZF+DIN-RegularItalic Flags: Nonsymbolic FontBBox: -148, -225, 1066, 984 FontFile3: true Encoding: WinAnsiEncoding ToUnicode: true CIDFontType2: Font: BaseFont: MIBZHP+SymbolMT CIDSystemInfo: Registry: Adobe Registry: Identity Supplement: 0 FontDescriptor: FontName: MIBZHP+SymbolMT Flags: Symbolic FontBBox: 0, -220, 1113, 1005 FontFile2: true XMP: application/pdfdoi:10.1177/1756284819857358 10.1177/1756284819857358https://doi.org/10.1177/1756284819857358 2019-08-05truejournals.sagepub.com10.1177/1756284819857358 journals.sagepub.comtrue10.1177/17562848198573582019-08-05 Pages: Page: Sequence: 1 Annotations: Annotation: Subtype: Link Rect: 491, 633, 558, 626 Annotation: Subtype: Link Rect: 491, 625, 527, 617 Annotation: Subtype: Link Rect: 42, 50, 136, 42 Annotation: Subtype: Link Rect: 491, 409, 549, 401 Annotation: Subtype: Link Rect: 491, 401, 524, 393 Annotation: Subtype: Link Rect: 25, 788, 89, 775 Page: Sequence: 2 Annotations: Annotation: Subtype: Link Rect: 458, 50, 552, 42 Annotation: Subtype: Link Rect: 482, 338, 521, 327 Page: Sequence: 3 Annotations: Annotation: Subtype: Link Rect: 42, 50, 136, 42 Page: Sequence: 4 Annotations: Annotation: Subtype: Link Rect: 458, 50, 552, 42 Page: Sequence: 5 Annotations: Annotation: Subtype: Link Rect: 42, 50, 136, 42 Page: Sequence: 6 Annotations: Annotation: Subtype: Link Rect: 458, 50, 552, 42 Page: Sequence: 7 Annotations: Annotation: Subtype: Link Rect: 42, 50, 136, 42 Annotation: Subtype: Link Rect: 406, 218, 444, 207 Annotation: Subtype: Link Rect: 454, 147, 481, 135 Annotation: Subtype: Link Rect: 268, 134, 291, 123 Annotation: Subtype: Link Rect: 271, 110, 327, 99 Page: Sequence: 8 Annotations: Annotation: Subtype: Link Rect: 458, 50, 552, 42 Annotation: Subtype: Link Rect: 225, 422, 267, 411 Annotation: Subtype: Link Rect: 117, 338, 163, 327 Annotation: Subtype: Link Rect: 261, 302, 327, 291 Annotation: Subtype: Link Rect: 113, 290, 156, 279 Page: Sequence: 9 Annotations: Annotation: Subtype: Link Rect: 42, 50, 136, 42 Page: Sequence: 10 Annotations: Annotation: Subtype: Link Rect: 458, 50, 552, 42 Page: Sequence: 11 Annotations: Annotation: Subtype: Link Rect: 42, 50, 136, 42 Page: Sequence: 12 Annotations: Annotation: Subtype: Link Rect: 458, 50, 552, 42 Page: Sequence: 13 Annotations: Annotation: Subtype: Link Rect: 42, 50, 136, 42 Page: Sequence: 14 Annotations: Annotation: Subtype: Link Rect: 458, 50, 552, 42 Annotation: Subtype: Link Rect: 231, 645, 312, 635 Annotation: Subtype: Link Rect: 131, 634, 322, 624 Annotation: Subtype: Link Rect: 131, 623, 316, 613 Annotation: Subtype: Link Rect: 357, 217, 534, 206 Annotation: Subtype: Link Rect: 357, 206, 523, 195 Annotation: Subtype: Link Rect: 357, 195, 495, 185 Annotation: Subtype: Link Rect: 26, 205, 92, 197 Annotation: Subtype: Link Rect: 26, 197, 54, 189 Checksum: b01e4c46 Type: CRC32 Checksum: 867b9d09c2ac35b34ed6eb49c80be61e Type: MD5 Checksum: a89a43f4c1734a69d71b4fed0a05014e09a90104 Type: SHA-1