5a289f9a93bb48a70b8649395d76c6a8 253336.pdf 6c79e8a44fdc4a6f1798630a15214bd9ef5e63c9 253336.pdf 235e86747ba366ea5f6cf87b1333557cfc40360b9905ba94301ba0d1cc9e8d6d 253336.pdf Title: Glucagon-Like Peptide-1 Receptor Agonists in Patients with Type 2 Diabetes: Prescription According to Reimbursement Constraints and Guideline Recommendations in Catalonia Subject: To assess the clinical characteristics, the prescription pattern of GLP-1 receptor agonists (GLP-1RA) users, and HbA1c and weight change, we retrospectively assessed patients with type 2 diabetes by initiating GLP-1RA as an add-on to the standard of care in Catalonia. The mean change from the baseline in glycated hemoglobin (HbA1c) and weight at 6 and 12 months of therapy was calculated, and we assessed the predictors of the HbA1c reduction of 1% and/or the weight reduction of 3% as recommended by the Catalan Health Service. In 2854 patients who initiated a GLP-1RA during 2014 and 2015, the overall mean HbA1c values were reduced from the baseline by -0.84% (SD = 1.66) (-9.2 mmol/mol) and lost on average 2.73 kg (SD = 6.2). About 44% percent of patients decreased their HbA1c by 1%; 44% decreased their weight by 3%; and only 22% met both of them together. The odds of achieving a reduction of 1% in initial HbA1c were two-fold higher for patients with higher baseline levels, and the likelihood of a reduction of 3% in the initial weight was associated with a higher BMI at the baseline, but they were independent of each other. The composite outcome (target 1% HbA1c reduction and 3% weight loss) to evaluate both the GLP-1RA clinical benefit and treatment withdrawal should be judged from a patient-centered approach. Keywords: GLP-1 analogue; type 2 diabetes mellitus; primary care; observational study; glycaemic control Author: Josep Franch-Nadal, Manel Mata-Cases, Emilio Ortega, Jordi Real, Mònica Gratacòs, Bogdan Vlacho, Joan Antoni Vallés and Dídac Mauricio Creator: LaTeX with hyperref package Producer: pdfTeX-1.40.18 CreationDate: Thu Sep 5 10:51:34 2019 CEST ModDate: Thu Sep 5 10:51:34 2019 CEST Tagged: no UserProperties: no Suspects: no Form: none JavaScript: no Pages: 17 Encrypted: no Page size: 595.276 x 841.89 pts (A4) Page rot: 0 File size: 911821 bytes Optimized: no PDF version: 1.5 name type encoding emb sub uni object ID ------------------------------------ ----------------- ---------------- --- --- --- --------- BZIILT+URWPalladioL-Ital Type 1 Custom yes yes no 94 0 UMCAUJ+URWPalladioL-Bold Type 1 Custom yes yes no 95 0 BFQLJI+VnURWPalladioL-Bold Type 1 Custom yes yes no 96 0 TWUTPL+URWPalladioL-Roma Type 1 Custom yes yes no 97 0 QLTJNU+VnURWPalladioL Type 1 Custom yes yes no 98 0 OFLXAT+Rpxr Type 1 Builtin yes yes no 99 0 FQVKWM+Pxsy Type 1 Builtin yes yes no 100 0 CAMXTK+EURM10 Type 1 Builtin yes yes no 101 0 BSDWLC+TimesNewRomanPSMT Type 1C WinAnsi yes yes no 106 0 XPUSBJ+TimesNewRomanPS-BoldItalicMT Type 1C WinAnsi yes yes no 107 0 MCBCCI+SourceSansRoman-Regular Type 1C Custom yes yes no 126 0 MCBCCM+SourceSansRoman.613wght Type 1C Custom yes yes no 127 0 MCBCCO+SourceSansRoman-Bold Type 1C Custom yes yes no 128 0 QLBIEB+URWPalladioL-BoldItal Type 1 Custom yes yes no 221 0 VUPETJ+Rpxb Type 1 Builtin yes yes no 222 0 HOCPOK+PalatinoLinotype CID TrueType Identity-H yes yes yes 239 0 HOCPOL+PalatinoLinotype TrueType WinAnsi yes yes no 240 0 HODAGK+PalatinoLinotype,Italic TrueType WinAnsi yes yes no 241 0 HODAIL+PalatinoLinotype,Bold TrueType WinAnsi yes yes no 242 0 HODCON+TimesNewRoman CID TrueType Identity-H yes yes yes 243 0 HOCPOK+PalatinoLinotype CID TrueType Identity-H yes yes yes 270 0 HODHIE+PalatinoLinotype,BoldItalic TrueType WinAnsi yes yes no 271 0 HODMGH+Arial CID TrueType Identity-H yes yes yes 272 0 HODMHI+Arial,Bold CID TrueType Identity-H yes yes yes 273 0 HOCPOL+PalatinoLinotype TrueType WinAnsi yes yes no 274 0 HODAGK+PalatinoLinotype,Italic TrueType WinAnsi yes yes no 275 0 HODAIL+PalatinoLinotype,Bold TrueType WinAnsi yes yes no 276 0 HODCON+TimesNewRoman CID TrueType Identity-H yes yes yes 277 0 VSHNAE+Rpcxr Type 1 Builtin yes yes no 474 0 Jhove (Rel. 1.22.1, 2019-04-17) Date: 2022-06-02 02:46:38 CEST RepresentationInformation: 253336.pdf ReportingModule: PDF-hul, Rel. 1.12.1 (2019-04-17) LastModified: 2022-05-25 17:26:12 CEST Size: 911821 Format: PDF Version: 1.5 Status: Well-Formed and valid SignatureMatches: PDF-hul MIMEtype: application/pdf PDFMetadata: Objects: 0 FreeObjects: 1 IncrementalUpdates: 0 DocumentCatalog: ViewerPreferences: HideToolbar: false HideMenubar: false HideWindowUI: false FitWindow: true CenterWindow: false DisplayDocTitle: false NonFullScreenPageMode: UseNone Direction: L2R ViewArea: CropBox ViewClip: CropBox PrintArea: CropBox PageClip: CropBox PageLayout: SinglePage PageMode: UseNone Outlines: Item: Title: ぉのぴひはつふっぴどはのぜ〴〩਼㰠⽓ 䝯呯 䐠⡳散瑩潮⸲ Item: Title: ぅへばづひどねづのぴちぬぜ〴ぜ〰こづっぴどはのぜ〴〩਼㰠⽓ 䝯呯 䐠⡳畢獥捴楯渮㈮ㄩ‾㸊⡜㌷㙜㌷㝜〰こぴふつべぜ〴ぜ〰ぐはばふぬちぴどはのぜ〴〩਼㰠⽓ 䝯呯 䐠⡳畢獥捴楯渮㈮㈩‾㸊⡜㌷㙜㌷㝜〰ぉのっぬふびどはのぜ〴ぜ〰ちのつぜ〴ぜ〰ぅへっぬふびどはのぜ〴ぜ〰ぃひどぴづひどちぜ〴〩਼㰠⽓ 䝯呯 䐠⡳畢獥捴楯渮㈮㌩‾㸊⡜㌷㙜㌷㝜〰こぴふつべぜ〴ぜ〰ざちひどちぢぬづびぜ〴〩਼㰠⽓ 䝯呯 䐠⡳畢獥捴楯渮㈮㐩‾㸊⡜㌷㙜㌷㝜〰こぴちぴどびぴどっちぬぜ〴ぜ〰きづぴとはつびぜ〴〩਼㰠⽓ 䝯呯 䐠⡳散瑩潮⸳ Children: Item: Title: こぴふつべぜ〴ぜ〰ぐはばふぬちぴどはのぜ〴〩਼㰠⽓ 䝯呯 䐠⡳畢獥捴楯渮㈮㈩‾㸊⡜㌷㙜㌷㝜〰ぉのっぬふびどはのぜ〴ぜ〰ちのつぜ〴ぜ〰ぅへっぬふびどはのぜ〴ぜ〰ぃひどぴづひどちぜ〴〩਼㰠⽓ 䝯呯 䐠⡳畢獥捴楯渮㈮㌩‾㸊⡜㌷㙜㌷㝜〰こぴふつべぜ〴ぜ〰ざちひどちぢぬづびぜ〴〩਼㰠⽓ 䝯呯 䐠⡳畢獥捴楯渮㈮㐩‾㸊⡜㌷㙜㌷㝜〰こぴちぴどびぴどっちぬぜ〴ぜ〰きづぴとはつびぜ〴〩਼㰠⽓ 䝯呯 䐠⡳散瑩潮⸳ Item: Title: ぉのっぬふびどはのぜ〴ぜ〰ちのつぜ〴ぜ〰ぅへっぬふびどはのぜ〴ぜ〰ぃひどぴづひどちぜ〴〩਼㰠⽓ 䝯呯 䐠⡳畢獥捴楯渮㈮㌩‾㸊⡜㌷㙜㌷㝜〰こぴふつべぜ〴ぜ〰ざちひどちぢぬづびぜ〴〩਼㰠⽓ 䝯呯 䐠⡳畢獥捴楯渮㈮㐩‾㸊⡜㌷㙜㌷㝜〰こぴちぴどびぴどっちぬぜ〴ぜ〰きづぴとはつびぜ〴〩਼㰠⽓ 䝯呯 䐠⡳散瑩潮⸳ Item: Title: こぴふつべぜ〴ぜ〰ざちひどちぢぬづびぜ〴〩਼㰠⽓ 䝯呯 䐠⡳畢獥捴楯渮㈮㐩‾㸊⡜㌷㙜㌷㝜〰こぴちぴどびぴどっちぬぜ〴ぜ〰きづぴとはつびぜ〴〩਼㰠⽓ 䝯呯 䐠⡳散瑩潮⸳ Item: Title: こぴちぴどびぴどっちぬぜ〴ぜ〰きづぴとはつびぜ〴〩਼㰠⽓ 䝯呯 䐠⡳散瑩潮⸳ Item: Title: げづびふぬぴびぜ〴〩਼㰠⽓ 䝯呯 䐠⡳畢獥捴楯渮㌮ㄩ‾㸊⡜㌷㙜㌷㝜〰ぐちぴどづのぴびぜ〳ㅜ〰ぜ〴ぜ〰ぃとちひちっぴづひどびぴどっびぜ〴〩਼㰠⽓ 䝯呯 䐠⡳畢獥捴楯渮㌮㈩‾㸊⡜㌷㙜㌷㝜〰ぁつづぱふちっべぜ〴ぜ〰ぴはぜ〴ぜ〰ぇがぐ〭〱げぁびぜ〴ぜ〰こねぐぃぜ〴ぜ〰ちのつぜ〴ぜ〰がはっちぬぜ〴ぜ〰えづちぬぴとぜ〴ぜ〰ぐはぬどっべぜ〴ぜ〰げづぱふどひづねづのぴびぜ〴ぜ〰てはひぜ〴ぜ〰げづどねぢふひびづねづのぴぜ〴〩਼㰠⽓ 䝯呯 䐠⡳畢獥捴楯渮㌮㌩‾㸊⡜㌷㙜㌷㝜〰ごひづちぴねづのぴぜ〴ぜ〰げづびばはのびづぜ〴ぜ〰ちてぴづひぜ〴ぜ〰こどへぜ〴ぜ〰ちのつぜ〴ぜ〰ごぷづぬぶづぜ〴ぜ〰きはのぴとびぜ〴ぜ〰はてぜ〴ぜ〰ぇがぐ〭〱げぁぜ〴ぜ〰ぉのどぴどちぴどはのぜ〴〩਼㰠⽓ 䝯呯 䐠⡳畢獥捴楯渮㌮㐩‾㸊⡜㌷㙜㌷㝜〰ぁびびづびびねづのぴぜ〴ぜ〰はてぜ〴ぜ〰あづのづてどっどちぬぜ〴ぜ〰げづびばはのびづぜ〴〩਼㰠⽓ 䝯呯 䐠⡳畢獥捴楯渮㌮㔩‾㸊⡜㌷㙜㌷㝜〰きづつどっちぴどはのぜ〴ぜ〰ぐづひびどびぴづのっづぜ〴ぜ〰ちのつぜ〴ぜ〰ぁつとづひづのっづぜ〴〩਼㰠⽓ 䝯呯 䐠⡳畢獥捴楯渮㌮㘩‾㸊⡜㌷㙜㌷㝜〰ぁつぶづひびづぜ〴ぜ〰ぅぶづのぴびぜ〴〩਼㰠⽓ 䝯呯 䐠⡳畢獥捴楯渮㌮㜩‾㸊⡜㌷㙜㌷㝜〰ざちひどちぢぬづびぜ〴ぜ〰ぁびびはっどちぴづつぜ〴ぜ〰ぷどぴとぜ〴ぜ〰あづのづてどっどちぬぜ〴ぜ〰えぢぁ〱っぜ〴ぜ〰げづつふっぴどはのぜ〴ぜ〰ちのつぜ〴ぜ〰しづどでとぴぜ〴ぜ〰がはびびぜ〴ぜ〰ちてぴづひぜ〴ぜ〰ごとづひちばべぜ〴ぜ〰ぷどぴとぜ〴ぜ〰ぇがぐ〭〱げぁびぜ〴〩਼㰠⽓ 䝯呯 䐠⡳散瑩潮⸴ Children: Item: Title: ぐちぴどづのぴびぜ〳ㅜ〰ぜ〴ぜ〰ぃとちひちっぴづひどびぴどっびぜ〴〩਼㰠⽓ 䝯呯 䐠⡳畢獥捴楯渮㌮㈩‾㸊⡜㌷㙜㌷㝜〰ぁつづぱふちっべぜ〴ぜ〰ぴはぜ〴ぜ〰ぇがぐ〭〱げぁびぜ〴ぜ〰こねぐぃぜ〴ぜ〰ちのつぜ〴ぜ〰がはっちぬぜ〴ぜ〰えづちぬぴとぜ〴ぜ〰ぐはぬどっべぜ〴ぜ〰げづぱふどひづねづのぴびぜ〴ぜ〰てはひぜ〴ぜ〰げづどねぢふひびづねづのぴぜ〴〩਼㰠⽓ 䝯呯 䐠⡳畢獥捴楯渮㌮㌩‾㸊⡜㌷㙜㌷㝜〰ごひづちぴねづのぴぜ〴ぜ〰げづびばはのびづぜ〴ぜ〰ちてぴづひぜ〴ぜ〰こどへぜ〴ぜ〰ちのつぜ〴ぜ〰ごぷづぬぶづぜ〴ぜ〰きはのぴとびぜ〴ぜ〰はてぜ〴ぜ〰ぇがぐ〭〱げぁぜ〴ぜ〰ぉのどぴどちぴどはのぜ〴〩਼㰠⽓ 䝯呯 䐠⡳畢獥捴楯渮㌮㐩‾㸊⡜㌷㙜㌷㝜〰ぁびびづびびねづのぴぜ〴ぜ〰はてぜ〴ぜ〰あづのづてどっどちぬぜ〴ぜ〰げづびばはのびづぜ〴〩਼㰠⽓ 䝯呯 䐠⡳畢獥捴楯渮㌮㔩‾㸊⡜㌷㙜㌷㝜〰きづつどっちぴどはのぜ〴ぜ〰ぐづひびどびぴづのっづぜ〴ぜ〰ちのつぜ〴ぜ〰ぁつとづひづのっづぜ〴〩਼㰠⽓ 䝯呯 䐠⡳畢獥捴楯渮㌮㘩‾㸊⡜㌷㙜㌷㝜〰ぁつぶづひびづぜ〴ぜ〰ぅぶづのぴびぜ〴〩਼㰠⽓ 䝯呯 䐠⡳畢獥捴楯渮㌮㜩‾㸊⡜㌷㙜㌷㝜〰ざちひどちぢぬづびぜ〴ぜ〰ぁびびはっどちぴづつぜ〴ぜ〰ぷどぴとぜ〴ぜ〰あづのづてどっどちぬぜ〴ぜ〰えぢぁ〱っぜ〴ぜ〰げづつふっぴどはのぜ〴ぜ〰ちのつぜ〴ぜ〰しづどでとぴぜ〴ぜ〰がはびびぜ〴ぜ〰ちてぴづひぜ〴ぜ〰ごとづひちばべぜ〴ぜ〰ぷどぴとぜ〴ぜ〰ぇがぐ〭〱げぁびぜ〴〩਼㰠⽓ 䝯呯 䐠⡳散瑩潮⸴ Item: Title: ぁつづぱふちっべぜ〴ぜ〰ぴはぜ〴ぜ〰ぇがぐ〭〱げぁびぜ〴ぜ〰こねぐぃぜ〴ぜ〰ちのつぜ〴ぜ〰がはっちぬぜ〴ぜ〰えづちぬぴとぜ〴ぜ〰ぐはぬどっべぜ〴ぜ〰げづぱふどひづねづのぴびぜ〴ぜ〰てはひぜ〴ぜ〰げづどねぢふひびづねづのぴぜ〴〩਼㰠⽓ 䝯呯 䐠⡳畢獥捴楯渮㌮㌩‾㸊⡜㌷㙜㌷㝜〰ごひづちぴねづのぴぜ〴ぜ〰げづびばはのびづぜ〴ぜ〰ちてぴづひぜ〴ぜ〰こどへぜ〴ぜ〰ちのつぜ〴ぜ〰ごぷづぬぶづぜ〴ぜ〰きはのぴとびぜ〴ぜ〰はてぜ〴ぜ〰ぇがぐ〭〱げぁぜ〴ぜ〰ぉのどぴどちぴどはのぜ〴〩਼㰠⽓ 䝯呯 䐠⡳畢獥捴楯渮㌮㐩‾㸊⡜㌷㙜㌷㝜〰ぁびびづびびねづのぴぜ〴ぜ〰はてぜ〴ぜ〰あづのづてどっどちぬぜ〴ぜ〰げづびばはのびづぜ〴〩਼㰠⽓ 䝯呯 䐠⡳畢獥捴楯渮㌮㔩‾㸊⡜㌷㙜㌷㝜〰きづつどっちぴどはのぜ〴ぜ〰ぐづひびどびぴづのっづぜ〴ぜ〰ちのつぜ〴ぜ〰ぁつとづひづのっづぜ〴〩਼㰠⽓ 䝯呯 䐠⡳畢獥捴楯渮㌮㘩‾㸊⡜㌷㙜㌷㝜〰ぁつぶづひびづぜ〴ぜ〰ぅぶづのぴびぜ〴〩਼㰠⽓ 䝯呯 䐠⡳畢獥捴楯渮㌮㜩‾㸊⡜㌷㙜㌷㝜〰ざちひどちぢぬづびぜ〴ぜ〰ぁびびはっどちぴづつぜ〴ぜ〰ぷどぴとぜ〴ぜ〰あづのづてどっどちぬぜ〴ぜ〰えぢぁ〱っぜ〴ぜ〰げづつふっぴどはのぜ〴ぜ〰ちのつぜ〴ぜ〰しづどでとぴぜ〴ぜ〰がはびびぜ〴ぜ〰ちてぴづひぜ〴ぜ〰ごとづひちばべぜ〴ぜ〰ぷどぴとぜ〴ぜ〰ぇがぐ〭〱げぁびぜ〴〩਼㰠⽓ 䝯呯 䐠⡳散瑩潮⸴ Item: Title: ごひづちぴねづのぴぜ〴ぜ〰げづびばはのびづぜ〴ぜ〰ちてぴづひぜ〴ぜ〰こどへぜ〴ぜ〰ちのつぜ〴ぜ〰ごぷづぬぶづぜ〴ぜ〰きはのぴとびぜ〴ぜ〰はてぜ〴ぜ〰ぇがぐ〭〱げぁぜ〴ぜ〰ぉのどぴどちぴどはのぜ〴〩਼㰠⽓ 䝯呯 䐠⡳畢獥捴楯渮㌮㐩‾㸊⡜㌷㙜㌷㝜〰ぁびびづびびねづのぴぜ〴ぜ〰はてぜ〴ぜ〰あづのづてどっどちぬぜ〴ぜ〰げづびばはのびづぜ〴〩਼㰠⽓ 䝯呯 䐠⡳畢獥捴楯渮㌮㔩‾㸊⡜㌷㙜㌷㝜〰きづつどっちぴどはのぜ〴ぜ〰ぐづひびどびぴづのっづぜ〴ぜ〰ちのつぜ〴ぜ〰ぁつとづひづのっづぜ〴〩਼㰠⽓ 䝯呯 䐠⡳畢獥捴楯渮㌮㘩‾㸊⡜㌷㙜㌷㝜〰ぁつぶづひびづぜ〴ぜ〰ぅぶづのぴびぜ〴〩਼㰠⽓ 䝯呯 䐠⡳畢獥捴楯渮㌮㜩‾㸊⡜㌷㙜㌷㝜〰ざちひどちぢぬづびぜ〴ぜ〰ぁびびはっどちぴづつぜ〴ぜ〰ぷどぴとぜ〴ぜ〰あづのづてどっどちぬぜ〴ぜ〰えぢぁ〱っぜ〴ぜ〰げづつふっぴどはのぜ〴ぜ〰ちのつぜ〴ぜ〰しづどでとぴぜ〴ぜ〰がはびびぜ〴ぜ〰ちてぴづひぜ〴ぜ〰ごとづひちばべぜ〴ぜ〰ぷどぴとぜ〴ぜ〰ぇがぐ〭〱げぁびぜ〴〩਼㰠⽓ 䝯呯 䐠⡳散瑩潮⸴ Item: Title: ぁびびづびびねづのぴぜ〴ぜ〰はてぜ〴ぜ〰あづのづてどっどちぬぜ〴ぜ〰げづびばはのびづぜ〴〩਼㰠⽓ 䝯呯 䐠⡳畢獥捴楯渮㌮㔩‾㸊⡜㌷㙜㌷㝜〰きづつどっちぴどはのぜ〴ぜ〰ぐづひびどびぴづのっづぜ〴ぜ〰ちのつぜ〴ぜ〰ぁつとづひづのっづぜ〴〩਼㰠⽓ 䝯呯 䐠⡳畢獥捴楯渮㌮㘩‾㸊⡜㌷㙜㌷㝜〰ぁつぶづひびづぜ〴ぜ〰ぅぶづのぴびぜ〴〩਼㰠⽓ 䝯呯 䐠⡳畢獥捴楯渮㌮㜩‾㸊⡜㌷㙜㌷㝜〰ざちひどちぢぬづびぜ〴ぜ〰ぁびびはっどちぴづつぜ〴ぜ〰ぷどぴとぜ〴ぜ〰あづのづてどっどちぬぜ〴ぜ〰えぢぁ〱っぜ〴ぜ〰げづつふっぴどはのぜ〴ぜ〰ちのつぜ〴ぜ〰しづどでとぴぜ〴ぜ〰がはびびぜ〴ぜ〰ちてぴづひぜ〴ぜ〰ごとづひちばべぜ〴ぜ〰ぷどぴとぜ〴ぜ〰ぇがぐ〭〱げぁびぜ〴〩਼㰠⽓ 䝯呯 䐠⡳散瑩潮⸴ Item: Title: きづつどっちぴどはのぜ〴ぜ〰ぐづひびどびぴづのっづぜ〴ぜ〰ちのつぜ〴ぜ〰ぁつとづひづのっづぜ〴〩਼㰠⽓ 䝯呯 䐠⡳畢獥捴楯渮㌮㘩‾㸊⡜㌷㙜㌷㝜〰ぁつぶづひびづぜ〴ぜ〰ぅぶづのぴびぜ〴〩਼㰠⽓ 䝯呯 䐠⡳畢獥捴楯渮㌮㜩‾㸊⡜㌷㙜㌷㝜〰ざちひどちぢぬづびぜ〴ぜ〰ぁびびはっどちぴづつぜ〴ぜ〰ぷどぴとぜ〴ぜ〰あづのづてどっどちぬぜ〴ぜ〰えぢぁ〱っぜ〴ぜ〰げづつふっぴどはのぜ〴ぜ〰ちのつぜ〴ぜ〰しづどでとぴぜ〴ぜ〰がはびびぜ〴ぜ〰ちてぴづひぜ〴ぜ〰ごとづひちばべぜ〴ぜ〰ぷどぴとぜ〴ぜ〰ぇがぐ〭〱げぁびぜ〴〩਼㰠⽓ 䝯呯 䐠⡳散瑩潮⸴ Item: Title: ぁつぶづひびづぜ〴ぜ〰ぅぶづのぴびぜ〴〩਼㰠⽓ 䝯呯 䐠⡳畢獥捴楯渮㌮㜩‾㸊⡜㌷㙜㌷㝜〰ざちひどちぢぬづびぜ〴ぜ〰ぁびびはっどちぴづつぜ〴ぜ〰ぷどぴとぜ〴ぜ〰あづのづてどっどちぬぜ〴ぜ〰えぢぁ〱っぜ〴ぜ〰げづつふっぴどはのぜ〴ぜ〰ちのつぜ〴ぜ〰しづどでとぴぜ〴ぜ〰がはびびぜ〴ぜ〰ちてぴづひぜ〴ぜ〰ごとづひちばべぜ〴ぜ〰ぷどぴとぜ〴ぜ〰ぇがぐ〭〱げぁびぜ〴〩਼㰠⽓ 䝯呯 䐠⡳散瑩潮⸴ Item: Title: ざちひどちぢぬづびぜ〴ぜ〰ぁびびはっどちぴづつぜ〴ぜ〰ぷどぴとぜ〴ぜ〰あづのづてどっどちぬぜ〴ぜ〰えぢぁ〱っぜ〴ぜ〰げづつふっぴどはのぜ〴ぜ〰ちのつぜ〴ぜ〰しづどでとぴぜ〴ぜ〰がはびびぜ〴ぜ〰ちてぴづひぜ〴ぜ〰ごとづひちばべぜ〴ぜ〰ぷどぴとぜ〴ぜ〰ぇがぐ〭〱げぁびぜ〴〩਼㰠⽓ 䝯呯 䐠⡳散瑩潮⸴ Item: Title: いどびっふびびどはのぜ〴〩਼㰠⽓ 䝯呯 䐠⡳散瑩潮⸵ Item: Title: ぃはのっぬふびどはのびぜ〴〩਼㰠⽓ 䝯呯 䐠⡳散瑩潮⸵ Item: Title: げづてづひづのっづび Filters: FilterPipeline: FlateDecode Fonts: Type1: Font: BaseFont: BFQLJI+VnURWPalladioL-Bold FontSubset: true FirstChar: 178 LastChar: 225 FontDescriptor: FontName: BFQLJI+VnURWPalladioL-Bold Flags: Symbolic FontBBox: -152, -301, 1000, 935 FontFile: true EncodingDictionary: Differences: true Font: BaseFont: TWUTPL+URWPalladioL-Roma FontSubset: true FirstChar: 2 LastChar: 241 FontDescriptor: FontName: TWUTPL+URWPalladioL-Roma Flags: Symbolic FontBBox: -166, -283, 1021, 943 FontFile: true EncodingDictionary: Differences: true Font: BaseFont: QLTJNU+VnURWPalladioL FontSubset: true FirstChar: 128 LastChar: 226 FontDescriptor: FontName: QLTJNU+VnURWPalladioL Flags: Symbolic FontBBox: -166, -283, 1021, 943 FontFile: true EncodingDictionary: Differences: true Font: BaseFont: OFLXAT+Rpxr FontSubset: true FirstChar: 11 LastChar: 62 FontDescriptor: FontName: OFLXAT+Rpxr Flags: Symbolic FontBBox: -40, -283, 904, 728 FontFile: true Font: BaseFont: FQVKWM+Pxsy FontSubset: true FirstChar: 0 LastChar: 21 FontDescriptor: FontName: FQVKWM+Pxsy Flags: Symbolic FontBBox: -21, -994, 1292, 912 FontFile: true Font: BaseFont: CAMXTK+EURM10 FontSubset: true FirstChar: 12 LastChar: 22 FontDescriptor: FontName: CAMXTK+EURM10 Flags: Symbolic FontBBox: -32, -243, 1060, 720 FontFile: true Font: BaseFont: VSHNAE+Rpcxr FontSubset: true FirstChar: 169 LastChar: 169 FontDescriptor: FontName: VSHNAE+Rpcxr Flags: Symbolic FontBBox: -212, -286, 1344, 973 FontFile: true Font: BaseFont: QLBIEB+URWPalladioL-BoldItal FontSubset: true FirstChar: 110 LastChar: 112 FontDescriptor: FontName: QLBIEB+URWPalladioL-BoldItal Flags: Symbolic FontBBox: -170, -300, 1073, 935 FontFile: true EncodingDictionary: Differences: true Font: BaseFont: BZIILT+URWPalladioL-Ital FontSubset: true FirstChar: 2 LastChar: 121 FontDescriptor: FontName: BZIILT+URWPalladioL-Ital Flags: Symbolic FontBBox: -170, -305, 1010, 941 FontFile: true EncodingDictionary: Differences: true Font: BaseFont: VUPETJ+Rpxb FontSubset: true FirstChar: 61 LastChar: 61 FontDescriptor: FontName: VUPETJ+Rpxb Flags: Symbolic FontBBox: -57, -266, 932, 729 FontFile: true Font: BaseFont: UMCAUJ+URWPalladioL-Bold FontSubset: true FirstChar: 3 LastChar: 150 FontDescriptor: FontName: UMCAUJ+URWPalladioL-Bold Flags: Symbolic FontBBox: -152, -301, 1000, 935 FontFile: true EncodingDictionary: Differences: true Pages: Page: Sequence: 1 Annotations: Annotation: Subtype: Link Rect: 75, 757, 217, 793 Annotation: Subtype: Link Rect: 474, 757, 519, 793 Annotation: Subtype: Link Rect: 294, 621, 305, 634 Annotation: Subtype: Link Rect: 240, 607, 251, 621 Annotation: Subtype: Link Rect: 473, 607, 484, 621 Annotation: Subtype: Link Rect: 466, 388, 518, 407 Annotation: Subtype: Link Rect: 181, 38, 251, 50 Annotation: Subtype: Link Rect: 418, 38, 519, 50 Page: Sequence: 2 Annotations: Annotation: Subtype: Link Rect: 131, 743, 138, 752 ActionDest: 400 Annotation: Subtype: Link Rect: 139, 743, 146, 752 ActionDest: 400 Annotation: Subtype: Link Rect: 106, 688, 113, 698 ActionDest: 400 Annotation: Subtype: Link Rect: 116, 688, 123, 698 ActionDest: 400 Annotation: Subtype: Link Rect: 463, 661, 470, 671 ActionDest: 400 Annotation: Subtype: Link Rect: 471, 661, 478, 671 ActionDest: 422 Annotation: Subtype: Link Rect: 326, 607, 333, 617 ActionDest: 422 Annotation: Subtype: Link Rect: 333, 607, 340, 617 ActionDest: 422 Annotation: Subtype: Link Rect: 202, 567, 214, 576 ActionDest: 422 Annotation: Subtype: Link Rect: 217, 567, 229, 576 ActionDest: 422 Annotation: Subtype: Link Rect: 146, 540, 158, 549 ActionDest: 422 Annotation: Subtype: Link Rect: 177, 513, 189, 522 ActionDest: 422 Annotation: Subtype: Link Rect: 433, 486, 440, 495 ActionDest: 422 Annotation: Subtype: Link Rect: 440, 486, 452, 495 ActionDest: 422 Annotation: Subtype: Link Rect: 453, 486, 465, 495 ActionDest: 422 Annotation: Subtype: Link Rect: 481, 459, 488, 468 ActionDest: 422 Annotation: Subtype: Link Rect: 488, 459, 500, 468 ActionDest: 422 Annotation: Subtype: Link Rect: 503, 459, 515, 468 ActionDest: 422 Annotation: Subtype: Link Rect: 122, 432, 129, 441 ActionDest: 400 Annotation: Subtype: Link Rect: 164, 405, 176, 414 ActionDest: 422 Annotation: Subtype: Link Rect: 151, 364, 163, 373 ActionDest: 422 Annotation: Subtype: Link Rect: 303, 310, 315, 319 ActionDest: 422 Annotation: Subtype: Link Rect: 316, 310, 328, 319 ActionDest: 422 Annotation: Subtype: Link Rect: 302, 297, 314, 306 ActionDest: 422 Annotation: Subtype: Link Rect: 315, 297, 327, 306 ActionDest: 422 Annotation: Subtype: Link Rect: 430, 243, 442, 252 ActionDest: 422 Page: Sequence: 3 Annotations: Annotation: Subtype: Link Rect: 131, 673, 143, 682 ActionDest: 422 Annotation: Subtype: Link Rect: 143, 673, 155, 682 ActionDest: 422 Page: Sequence: 4 Annotations: Annotation: Subtype: Link Rect: 194, 588, 206, 597 ActionDest: 422 Annotation: Subtype: Link Rect: 206, 588, 218, 597 ActionDest: 422 Annotation: Subtype: Link Rect: 511, 331, 518, 342 ActionDest: 209 Page: Sequence: 5 Annotations: Annotation: Subtype: Link Rect: 131, 349, 143, 358 ActionDest: 422 Annotation: Subtype: Link Rect: 143, 349, 155, 358 ActionDest: 422 Annotation: Subtype: Link Rect: 508, 223, 515, 235 ActionDest: 218 Annotation: Subtype: Link Rect: 215, 142, 222, 154 ActionDest: 218 Annotation: Subtype: Link Rect: 443, 128, 450, 140 ActionDest: 218 Page: Sequence: 6 Annotations: Annotation: Subtype: Link Rect: 271, 740, 278, 752 ActionDest: 218 Page: Sequence: 7 Page: Sequence: 8 Annotations: Annotation: Subtype: Link Rect: 236, 696, 248, 705 ActionDest: 422 Annotation: Subtype: Link Rect: 248, 696, 260, 705 ActionDest: 422 Annotation: Subtype: Link Rect: 110, 666, 117, 678 ActionDest: 233 Annotation: Subtype: Link Rect: 370, 558, 377, 572 ActionDest: 233 Page: Sequence: 9 Annotations: Annotation: Subtype: Link Rect: 221, 713, 228, 725 ActionDest: 264 Annotation: Subtype: Link Rect: 208, 699, 215, 713 ActionDest: 264 Page: Sequence: 10 Annotations: Annotation: Subtype: Link Rect: 144, 693, 151, 705 ActionDest: 313 Annotation: Subtype: Link Rect: 206, 545, 213, 557 ActionDest: 313 Page: Sequence: 11 Page: Sequence: 12 Annotations: Annotation: Subtype: Link Rect: 138, 588, 145, 597 ActionDest: 422 Annotation: Subtype: Link Rect: 146, 588, 158, 597 ActionDest: 422 Annotation: Subtype: Link Rect: 158, 588, 170, 597 ActionDest: 422 Annotation: Subtype: Link Rect: 171, 588, 183, 597 ActionDest: 422 Annotation: Subtype: Link Rect: 236, 561, 248, 570 ActionDest: 449 Annotation: Subtype: Link Rect: 251, 561, 263, 570 ActionDest: 449 Annotation: Subtype: Link Rect: 320, 466, 332, 475 ActionDest: 449 Annotation: Subtype: Link Rect: 335, 466, 347, 475 ActionDest: 449 Annotation: Subtype: Link Rect: 99, 426, 111, 435 ActionDest: 449 Annotation: Subtype: Link Rect: 417, 412, 429, 421 ActionDest: 449 Annotation: Subtype: Link Rect: 177, 358, 189, 367 ActionDest: 449 Annotation: Subtype: Link Rect: 340, 318, 352, 327 ActionDest: 449 Annotation: Subtype: Link Rect: 355, 318, 367, 327 ActionDest: 449 Annotation: Subtype: Link Rect: 108, 156, 120, 165 ActionDest: 449 Annotation: Subtype: Link Rect: 403, 88, 415, 97 ActionDest: 449 Annotation: Subtype: Link Rect: 416, 88, 428, 97 ActionDest: 449 Page: Sequence: 13 Annotations: Annotation: Subtype: Link Rect: 422, 743, 434, 752 ActionDest: 449 Annotation: Subtype: Link Rect: 434, 742, 446, 752 ActionDest: 449 Annotation: Subtype: Link Rect: 491, 729, 503, 738 ActionDest: 449 Annotation: Subtype: Link Rect: 476, 688, 488, 698 ActionDest: 449 Annotation: Subtype: Link Rect: 491, 688, 503, 698 ActionDest: 449 Annotation: Subtype: Link Rect: 503, 688, 515, 698 ActionDest: 449 Annotation: Subtype: Link Rect: 344, 634, 356, 644 ActionDest: 468 Annotation: Subtype: Link Rect: 359, 634, 371, 644 ActionDest: 468 Annotation: Subtype: Link Rect: 283, 607, 295, 617 ActionDest: 468 Annotation: Subtype: Link Rect: 221, 567, 233, 576 ActionDest: 449 Annotation: Subtype: Link Rect: 233, 567, 245, 576 ActionDest: 449 Annotation: Subtype: Link Rect: 246, 567, 258, 576 ActionDest: 468 Annotation: Subtype: Link Rect: 258, 567, 270, 576 ActionDest: 468 Annotation: Subtype: Link Rect: 273, 567, 285, 576 ActionDest: 468 Annotation: Subtype: Link Rect: 296, 553, 308, 562 ActionDest: 449 Annotation: Subtype: Link Rect: 308, 553, 320, 562 ActionDest: 449 Annotation: Subtype: Link Rect: 321, 553, 333, 562 ActionDest: 449 Annotation: Subtype: Link Rect: 333, 553, 345, 562 ActionDest: 468 Annotation: Subtype: Link Rect: 346, 553, 358, 562 ActionDest: 468 Annotation: Subtype: Link Rect: 503, 540, 515, 549 ActionDest: 449 Annotation: Subtype: Link Rect: 363, 472, 375, 481 ActionDest: 449 Annotation: Subtype: Link Rect: 375, 472, 387, 481 ActionDest: 468 Annotation: Subtype: Link Rect: 388, 472, 400, 481 ActionDest: 468 Annotation: Subtype: Link Rect: 400, 472, 412, 481 ActionDest: 468 Annotation: Subtype: Link Rect: 227, 418, 239, 427 ActionDest: 468 Annotation: Subtype: Link Rect: 239, 418, 251, 427 ActionDest: 468 Annotation: Subtype: Link Rect: 292, 161, 304, 171 ActionDest: 468 Page: Sequence: 14 Annotations: Annotation: Subtype: Link Rect: 337, 704, 518, 715 Annotation: Subtype: Link Rect: 141, 276, 178, 286 Annotation: Subtype: Link Rect: 100, 250, 137, 260 Annotation: Subtype: Link Rect: 429, 198, 466, 209 Annotation: Subtype: Link Rect: 355, 173, 393, 183 Annotation: Subtype: Link Rect: 175, 121, 212, 131 Annotation: Subtype: Link Rect: 284, 82, 321, 92 Page: Sequence: 15 Annotations: Annotation: Subtype: Link Rect: 275, 727, 312, 738 Annotation: Subtype: Link Rect: 100, 702, 137, 712 Annotation: Subtype: Link Rect: 448, 675, 486, 686 Annotation: Subtype: Link Rect: 328, 624, 366, 635 Annotation: Subtype: Link Rect: 422, 572, 459, 583 Annotation: Subtype: Link Rect: 316, 547, 354, 557 Annotation: Subtype: Link Rect: 136, 521, 174, 531 Annotation: Subtype: Link Rect: 252, 495, 289, 506 Annotation: Subtype: Link Rect: 255, 469, 293, 480 Annotation: Subtype: Link Rect: 344, 430, 381, 441 Annotation: Subtype: Link Rect: 324, 404, 362, 415 Annotation: Subtype: Link Rect: 137, 366, 174, 376 Annotation: Subtype: Link Rect: 328, 340, 365, 351 Annotation: Subtype: Link Rect: 225, 302, 263, 312 Annotation: Subtype: Link Rect: 246, 275, 403, 286 Annotation: Subtype: Link Rect: 368, 224, 467, 234 Annotation: Subtype: Link Rect: 372, 172, 409, 183 Annotation: Subtype: Link Rect: 469, 107, 507, 118 Page: Sequence: 16 Annotations: Annotation: Subtype: Link Rect: 172, 702, 210, 712 Annotation: Subtype: Link Rect: 136, 663, 173, 673 Annotation: Subtype: Link Rect: 172, 625, 210, 635 Annotation: Subtype: Link Rect: 458, 598, 495, 609 Annotation: Subtype: Link Rect: 412, 559, 450, 570 Annotation: Subtype: Link Rect: 295, 521, 332, 531 Annotation: Subtype: Link Rect: 328, 482, 365, 493 Annotation: Subtype: Link Rect: 432, 456, 469, 467 Annotation: Subtype: Link Rect: 293, 431, 330, 441 Annotation: Subtype: Link Rect: 418, 391, 456, 402 Annotation: Subtype: Link Rect: 418, 353, 456, 364 Annotation: Subtype: Link Rect: 145, 302, 183, 312 Annotation: Subtype: Link Rect: 146, 263, 184, 273 Annotation: Subtype: Link Rect: 276, 224, 314, 234 Annotation: Subtype: Link Rect: 100, 186, 137, 196 Annotation: Subtype: Link Rect: 272, 146, 309, 157 Annotation: Subtype: Link Rect: 361, 120, 399, 131 Annotation: Subtype: Link Rect: 370, 95, 408, 105 Annotation: Subtype: Link Rect: 468, 69, 505, 80 Page: Sequence: 17 Annotations: Annotation: Subtype: Link Rect: 435, 714, 472, 725 Annotation: Subtype: Link Rect: 399, 688, 437, 699 Annotation: Subtype: Link Rect: 262, 651, 299, 661 Annotation: Subtype: Link Rect: 350, 624, 388, 635 Annotation: Subtype: Link Rect: 227, 586, 265, 596 Annotation: Subtype: Link Rect: 172, 547, 210, 557 Annotation: Subtype: Link Rect: 402, 508, 439, 519 Annotation: Subtype: Link Rect: 476, 482, 513, 493 Annotation: Subtype: Link Rect: 205, 431, 242, 441 Annotation: Subtype: Link Rect: 76, 389, 166, 420 Annotation: Subtype: Link Rect: 234, 383, 407, 394 Checksum: f6d1c4c6 Type: CRC32 Checksum: 5a289f9a93bb48a70b8649395d76c6a8 Type: MD5 Checksum: 6c79e8a44fdc4a6f1798630a15214bd9ef5e63c9 Type: SHA-1