de1e9ae32d695ab08347cd01a878453a jcm-08-01805.pdf d47c686e637ec0679bcd7dbbfec99565519c8298 jcm-08-01805.pdf 2da31555eb1aa60d4df0001e5a34cdce5407576f9e9889c61c07d6a876b6393c jcm-08-01805.pdf Title: Microvascular Obstruction in ST-Segment Elevation Myocardial Infarction: Looking Back to Move Forward. Focus on CMR Subject: After a myocardial infarction (MI), despite the resolution of the coronary occlusion, the deterioration of myocardial perfusion persists in a considerable number of patients. This phenomenon is known as microvascular obstruction (MVO). Initially, the focus was placed on re-establishing blood flow in the epicardial artery. Then, the observation that MVO has profound negative structural and prognostic repercussions revived interest in microcirculation. In the near future, the availability of co-adjuvant therapies (beyond timely coronary reperfusion) aimed at preventing, minimizing, and repairing MVOs and finding convincing answers to questions regarding what, when, how, and where to administer these therapies will be of utmost importance. The objective of this work is to review the state-of-the-art concepts on pathophysiology, diagnostic methods, and structural and clinical implications of MVOs in patients with ST-segment elevation MIs. Based on this knowledge we discuss previously-tested and future opportunities for the prevention and repair of MVO. Keywords: myocardial infarction; microvascular obstruction; reperfusion injury Author: Cesar Rios-Navarro, Victor Marcos-Garces, Antoni Bayes-Genis, Oliver Husser, Julio Nuñez and Vicente Bodi Creator: LaTeX with hyperref package Producer: pdfTeX-1.40.18 CreationDate: Mon Oct 28 10:04:08 2019 CET ModDate: Mon Oct 28 10:04:08 2019 CET Tagged: no UserProperties: no Suspects: no Form: none JavaScript: no Pages: 19 Encrypted: no Page size: 595.276 x 841.89 pts (A4) Page rot: 0 File size: 3967218 bytes Optimized: no PDF version: 1.5 name type encoding emb sub uni object ID ------------------------------------ ----------------- ---------------- --- --- --- --------- GHXITF+URWPalladioL-Ital Type 1 Custom yes yes no 126 0 IMZOKK+URWPalladioL-Bold Type 1 Custom yes yes no 127 0 TGBEVB+URWPalladioL-Roma Type 1 Custom yes yes no 128 0 OPZDHV+VnURWPalladioL Type 1 Custom yes yes no 129 0 QANVCD+Rpxr Type 1 Builtin yes yes no 130 0 BSDWLC+TimesNewRomanPSMT Type 1C WinAnsi yes yes no 135 0 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LKODFI+PalatinoLinotype,Bold TrueType WinAnsi yes yes no 599 0 LKODNG+TimesNewRoman CID TrueType Identity-H yes yes yes 600 0 VSHNAE+Rpcxr Type 1 Builtin yes yes no 747 0 Jhove (Rel. 1.22.1, 2019-04-17) Date: 2023-07-26 02:35:46 CEST RepresentationInformation: jcm-08-01805.pdf ReportingModule: PDF-hul, Rel. 1.12.1 (2019-04-17) LastModified: 2023-07-25 14:44:04 CEST Size: 3967218 Format: PDF Version: 1.5 Status: Well-Formed and valid SignatureMatches: PDF-hul MIMEtype: application/pdf PDFMetadata: Objects: 0 FreeObjects: 4 IncrementalUpdates: 0 DocumentCatalog: ViewerPreferences: HideToolbar: false HideMenubar: false HideWindowUI: false FitWindow: true CenterWindow: false DisplayDocTitle: false NonFullScreenPageMode: UseNone Direction: L2R ViewArea: CropBox ViewClip: CropBox PrintArea: CropBox PageClip: CropBox PageLayout: SinglePage PageMode: UseNone Outlines: Item: Title: ぉのぴひはつふっぴどはのぜ〴〩਼㰠⽓ 䝯呯 䐠⡳散瑩潮⸲ Item: Title: ぐちぴとはばとべびどはぬはでべぜ〴〩਼㰠⽓ 䝯呯 䐠⡳畢獥捴楯渮㈮ㄩ‾㸊⡜㌷㙜㌷㝜〰ぐひづつはねどのちのぴぬべぜ〴ぜ〰ぐひどはひぜ〴ぜ〰ぴはぜ〴ぜ〰げづばづひてふびどはのぜ〴〩਼㰠⽓ 䝯呯 䐠⡳畢獵扳散瑩潮⸲⸱⸱ Children: Item: Title: ぐひづつはねどのちのぴぬべぜ〴ぜ〰ぐひどはひぜ〴ぜ〰ぴはぜ〴ぜ〰げづばづひてふびどはのぜ〴〩਼㰠⽓ 䝯呯 䐠⡳畢獵扳散瑩潮⸲⸱⸱ Children: Item: Title: ぐちぴどづのぴぜ〴ぜ〰うちっぴはひびぜ〴〩਼㰠⽓ 䝯呯 䐠⡳畢獵扳散瑩潮⸲⸱⸲ Item: Title: ぅのつはぴとづぬどちぬぜ〴ぜ〰ぁぢのはひねちぬどぴどづびぜ〴〩਼㰠⽓ 䝯呯 䐠⡳畢獵扳散瑩潮⸲⸱⸳ Item: Title: いづっひづちびづぜ〴ぜ〰どのぜ〴ぜ〰ぃちばどぬぬちひべぜ〴ぜ〰いづのびどぴべぜ〴〩਼㰠⽓ 䝯呯 䐠⡳畢獥捴楯渮㈮㈩‾㸊⡜㌷㙜㌷㝜〰ぐひづつはねどのちのぴぬべぜ〴ぜ〰ちぴぜ〴ぜ〰げづばづひてふびどはのぜ〴〩਼㰠⽓ 䝯呯 䐠⡳畢獵扳散瑩潮⸲⸲⸱ Item: Title: ぐひづつはねどのちのぴぬべぜ〴ぜ〰ちぴぜ〴ぜ〰げづばづひてふびどはのぜ〴〩਼㰠⽓ 䝯呯 䐠⡳畢獵扳散瑩潮⸲⸲⸱ Children: Item: Title: ぉびっとづねどち〭げづばづひてふびどはのぜ〴ぜ〰ぉのなふひべぜ〴〩਼㰠⽓ 䝯呯 䐠⡳畢獵扳散瑩潮⸲⸲⸲ Item: Title: ぅねぢはぬどぺちぴどはのぜ〴〩਼㰠⽓ 䝯呯 䐠⡳畢獵扳散瑩潮⸲⸲⸳ Item: Title: ざちびはっはのびぴひどっぴどはのぜ〴〩਼㰠⽓ 䝯呯 䐠⡳畢獥捴楯渮㈮㌩‾㸊⡜㌷㙜㌷㝜〰ぐひづつはねどのちのぴぬべぜ〴ぜ〰ぐはびぴ〭げづばづひてふびどはのぜ〴〩਼㰠⽓ 䝯呯 䐠⡳畢獵扳散瑩潮⸲⸳⸱ Item: Title: ぐひづつはねどのちのぴぬべぜ〴ぜ〰ぐはびぴ〭げづばづひてふびどはのぜ〴〩਼㰠⽓ 䝯呯 䐠⡳畢獵扳散瑩潮⸲⸳⸱ Children: Item: Title: ぉのっひづちびづぜ〴ぜ〰どのぜ〴ぜ〰ぅのつはぴとづぬどちぬぜ〴ぜ〰ぐづひねづちぢどぬどぴべぜ〴〩਼㰠⽓ 䝯呯 䐠⡳畢獵扳散瑩潮⸲⸳⸲ Item: Title: ぅへぴづひのちぬぜ〴ぜ〰ぃはねばひづびびどはのぜ〴〩਼㰠⽓ 䝯呯 䐠⡳畢獵扳散瑩潮⸲⸳⸳ Item: Title: 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