375d946f6a89bba664463e5b3234db53 Sole_M_et_al_BBA_MBD_2019.pdf 6d77aca56d77186d27735322ed386e0d93b5aa42 Sole_M_et_al_BBA_MBD_2019.pdf f2df8a5e022902553351f01efbad4ac781d69a560bd7be8e88b4a7b18f36e5cd Sole_M_et_al_BBA_MBD_2019.pdf Title: Blood-brain barrier dysfunction underlying Alzheimer's disease is induced by an SSAO/VAP-1-dependent cerebrovascular activation with enhanced Aβ deposition Subject: BBA - Molecular Basis of Disease, Accepted manuscript. doi:10.1016/j.bbadis.2019.04.016 Author: Montse Solé Creator: Elsevier Producer: iTextSharp™ 5.5.10 ©2000-2016 iText Group NV (AGPL-version) CreationDate: Mon Apr 29 23:11:42 2019 CEST ModDate: Mon May 6 14:26:39 2019 CEST Custom Metadata: yes Metadata Stream: yes Tagged: no UserProperties: no Suspects: no Form: none JavaScript: no Pages: 44 Encrypted: no Page size: 612 x 792 pts (letter) Page rot: 0 File size: 1903567 bytes Optimized: yes PDF version: 1.7 name type encoding emb sub uni object ID ------------------------------------ ----------------- ---------------- --- --- --- --------- PXAAAA+TimesNewRoman TrueType WinAnsi yes yes yes 312 0 PXAAAB+TimesNewRoman,Italic TrueType MacRoman yes yes no 314 0 ABCDEE+Calibri TrueType WinAnsi yes yes no 227 0 Arial-BoldMT TrueType WinAnsi no no no 223 0 Arial-BoldMT CID TrueType Identity-H yes no yes 246 0 SymbolMT CID TrueType Identity-H yes no yes 235 0 ArialMT TrueType WinAnsi no no no 237 0 Arial-ItalicMT TrueType WinAnsi no no no 242 0 ArialMT CID TrueType Identity-H yes no yes 245 0 Helvetica Type 1 WinAnsi no no no 241 0 Helvetica-Bold Type 1 WinAnsi no no no 240 0 ABCDEE+Arial Bold,Bold CID TrueType Identity-H yes yes yes 209 0 ArialMT CID TrueType Identity-H yes no yes 213 0 SymbolMT TrueType WinAnsi no no no 215 0 ABCDEE+Arial Bold,Bold TrueType WinAnsi yes yes no 217 0 ArialMT TrueType WinAnsi no no no 219 0 ABCDEE+CambriaMath CID TrueType Identity-H yes yes yes 247 0 Jhove (Rel. 1.28.0, 2023-05-18) Date: 2025-01-31 02:54:40 CET RepresentationInformation: Sole_M_et_al_BBA_MBD_2019.pdf ReportingModule: PDF-hul, Rel. 1.12.4 (2023-03-16) LastModified: 2025-01-29 08:32:56 CET Size: 1903567 Format: PDF Version: 1.7 Status: Well-Formed and valid SignatureMatches: PDF-hul MIMEtype: application/pdf Profile: Linearized PDF PDFMetadata: Objects: 0 FreeObjects: 1 IncrementalUpdates: 0 DocumentCatalog: PageLayout: SinglePage PageMode: UseThumbs Filters: FilterPipeline: FlateDecode FilterPipeline: DCTDecode Images: Image: NisoImageMetadata: FormatName: image/jpg CompressionScheme: JPEG ImageWidth: 960 ImageHeight: 1280 ColorSpace: RGB BitsPerSample: 8 BitsPerSampleUnit: integer Image: NisoImageMetadata: FormatName: image/png ImageWidth: 1014 ImageHeight: 711 ColorSpace: RGB BitsPerSample: 8 BitsPerSampleUnit: integer Filter: FlateDecode Interpolate: false Image: NisoImageMetadata: FormatName: image/jpg CompressionScheme: JPEG ImageWidth: 1042 ImageHeight: 909 ColorSpace: RGB BitsPerSample: 8 BitsPerSampleUnit: integer Interpolate: true Image: NisoImageMetadata: FormatName: image/png ImageWidth: 952 ImageHeight: 1101 ColorSpace: RGB BitsPerSample: 8 BitsPerSampleUnit: integer Filter: FlateDecode Interpolate: false Image: NisoImageMetadata: FormatName: image/png ImageWidth: 947 ImageHeight: 754 ColorSpace: RGB BitsPerSample: 8 BitsPerSampleUnit: integer Filter: FlateDecode Interpolate: false Image: NisoImageMetadata: FormatName: image/jpg CompressionScheme: JPEG ImageWidth: 1013 ImageHeight: 754 ColorSpace: RGB BitsPerSample: 8 BitsPerSampleUnit: integer Interpolate: true Image: NisoImageMetadata: FormatName: image/png ImageWidth: 956 ImageHeight: 902 ColorSpace: RGB BitsPerSample: 8 BitsPerSampleUnit: integer Filter: FlateDecode Interpolate: false Image: NisoImageMetadata: FormatName: image/png ImageWidth: 2 ImageHeight: 2 ColorSpace: palette color BitsPerSample: 1 BitsPerSampleUnit: integer Filter: FlateDecode Interpolate: false Fonts: Type0: Font: BaseFont: ArialMT Encoding: Identity-H ToUnicode: true Font: BaseFont: Arial-BoldMT Encoding: Identity-H ToUnicode: true Font: BaseFont: ABCDEE+CambriaMath Encoding: Identity-H ToUnicode: true Font: BaseFont: SymbolMT Encoding: Identity-H ToUnicode: true Type1: Font: BaseFont: Helvetica-Bold Encoding: WinAnsiEncoding Font: BaseFont: Helvetica Encoding: WinAnsiEncoding TrueType: Font: Name: F6 BaseFont: Arial-ItalicMT FirstChar: 32 LastChar: 243 FontDescriptor: FontName: Arial-ItalicMT Flags: Nonsymbolic FontBBox: -517, -208, 1359, 728 Encoding: WinAnsiEncoding Font: Name: F1 BaseFont: ABCDEE+Calibri FontSubset: true FirstChar: 32 LastChar: 57 FontDescriptor: FontName: ABCDEE+Calibri Flags: Nonsymbolic FontBBox: -503, -250, 1240, 750 FontFile2: true Encoding: WinAnsiEncoding Font: BaseFont: PXAAAA+TimesNewRoman FontSubset: true FirstChar: 1 LastChar: 67 FontDescriptor: FontName: TimesNewRoman Flags: Symbolic FontBBox: -568, -306, 2045, 1039 FontFile2: true ToUnicode: true Font: BaseFont: PXAAAB+TimesNewRoman,Italic FontSubset: true FirstChar: 32 LastChar: 255 FontDescriptor: FontName: TimesNewRoman,Italic Flags: Nonsymbolic, Italic FontBBox: -497, -306, 1333, 1023 FontFile2: true Encoding: MacRomanEncoding Font: Name: F5 BaseFont: ArialMT FirstChar: 32 LastChar: 252 FontDescriptor: FontName: ArialMT Flags: Nonsymbolic FontBBox: -665, -210, 2000, 728 Encoding: WinAnsiEncoding Font: Name: F2 BaseFont: Arial-BoldMT FirstChar: 32 LastChar: 121 FontDescriptor: FontName: Arial-BoldMT Flags: Nonsymbolic FontBBox: -628, -210, 2000, 728 Encoding: WinAnsiEncoding CIDFontType2: Font: BaseFont: SymbolMT CIDSystemInfo: Registry: Adobe Registry: Identity Supplement: 0 FontDescriptor: FontName: SymbolMT Flags: Nonsymbolic FontBBox: 0, -216, 1113, 693 FontFile2: true Font: BaseFont: Arial-BoldMT CIDSystemInfo: Registry: Adobe Registry: Identity Supplement: 0 FontDescriptor: FontName: Arial-BoldMT Flags: Nonsymbolic FontBBox: -628, -210, 2000, 728 FontFile2: true Font: BaseFont: ABCDEE+CambriaMath CIDSystemInfo: Registry: Adobe Registry: Identity Supplement: 0 FontDescriptor: FontName: ABCDEE+CambriaMath Flags: Nonsymbolic FontBBox: -1475, -222, 2868, 778 FontFile2: true Font: BaseFont: ArialMT CIDSystemInfo: Registry: Adobe Registry: Identity Supplement: 0 FontDescriptor: FontName: ArialMT Flags: Nonsymbolic FontBBox: -665, -210, 2000, 728 FontFile2: true XMP: Elsevier 2019-04-30T05:11:42+08:00 2019-05-06T14:26:39+02:00 2019-05-06T14:26:39+02:00 application/pdf doi:10.1016/j.bbadis.2019.04.016 Blood-brain barrier dysfunction underlying Alzheimer's disease is induced by an SSAO/VAP-1-dependent cerebrovascular activation with enhanced Aβ deposition Elsevier B.V BBA - Molecular Basis of Disease, Accepted manuscript. doi:10.1016/j.bbadis.2019.04.016 Montse Solé María Esteban-Lopez Biel Taltavull Cristina Fábregas Rut Fadó Núria Casals Jose Rodríguez-Álvarez Alfredo J. Miñano-Molina Mercedes Unzeta Alzheimer's disease (AD) Angioneurins Blood-brain barrier (BBB) Neurovascular unit (NVU) Semicarbazide-sensitive amine oxidase (SSAO/VAP-1) AM 0925-4439 https://doi.org/10.1016/j.bbadis.2019.04.016 10.1016/j.bbadis.2019.04.016 © 2019 Elsevier B.V. All rights reserved. BBA - Molecular Basis of Disease journal 2010-04-23 true 10.1016/j.bbadis.2019.04.016 elsevier.com sciencedirect.com 8c03f0a0-20c5-4609-97cd-205d741e5dd9:1556941032 10.1016/j.bbadis.2019.04.016 2010-04-23 true 6.5 3 sciencedirect.com elsevier.com True iTextSharp™ 5.5.10 ©2000-2016 iText Group NV (AGPL-version) uuid:1bf5c00b-2804-420f-81e7-745e05f32739 uuid:7b1a5503-8de6-407c-b839-ef1270c05c86 Pages: Page: Label: 1 Annotations: Annotation: Subtype: Link Rect: 213, 507, 427, 521 Annotation: Subtype: Link Rect: 227, 339, 441, 352 Page: Label: 2 Sequence: 2 Annotations: Annotation: Subtype: Link Rect: 82, 260, 204, 291 Flags: Print Page: Label: 3 Sequence: 3 Page: Label: 4 Sequence: 4 Page: Label: 5 Sequence: 5 Page: Label: 6 Sequence: 6 Page: Label: 7 Sequence: 7 Page: Label: 8 Sequence: 8 Page: Label: 9 Sequence: 9 Page: Label: 10 Sequence: 10 Page: Label: 11 Sequence: 11 Page: Label: 12 Sequence: 12 Page: Label: 13 Sequence: 13 Page: Label: 14 Sequence: 14 Page: Label: 15 Sequence: 15 Page: Label: 16 Sequence: 16 Page: Label: 17 Sequence: 17 Page: Label: 18 Sequence: 18 Page: Label: 19 Sequence: 19 Page: Label: 20 Sequence: 20 Page: Label: 21 Sequence: 21 Page: Label: 22 Sequence: 22 Page: Label: 23 Sequence: 23 Page: Label: 24 Sequence: 24 Page: Label: 25 Sequence: 25 Page: Label: 26 Sequence: 26 Page: Label: 27 Sequence: 27 Page: Label: 28 Sequence: 28 Page: Label: 29 Sequence: 29 Page: Label: 30 Sequence: 30 Page: Label: 31 Sequence: 31 Page: Label: 32 Sequence: 32 Page: Label: 33 Sequence: 33 Page: Label: 34 Sequence: 34 Page: Label: 35 Sequence: 35 Page: Label: 36 Sequence: 36 Page: Label: 37 Sequence: 37 Page: Label: 38 Sequence: 38 Page: Label: 39 Sequence: 39 Page: Label: 40 Sequence: 40 Page: Label: 41 Sequence: 41 Page: Label: 42 Sequence: 42 Page: Label: 43 Sequence: 43 Page: Label: 44 Sequence: 44 Checksum: 5118b402 Type: CRC32 Checksum: 375d946f6a89bba664463e5b3234db53 Type: MD5 Checksum: 6d77aca56d77186d27735322ed386e0d93b5aa42 Type: SHA-1 Checksum: f2df8a5e022902553351f01efbad4ac781d69a560bd7be8e88b4a7b18f36e5cd Type: SHA-256